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</a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Mélisande Bernard</h3></div><div class="js-work-strip profile--work_container" data-work-id="111588361"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588361/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs"><img alt="Research paper thumbnail of Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs" class="work-thumbnail" src="https://attachments.academia-assets.com/109083302/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588361/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs">Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs</a></div><div class="wp-workCard_item"><span>Journal of Separation Science</span><span>, Jan 19, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5be8f130f0122716ee092a39828bfffc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083302,"asset_id":111588361,"asset_type":"Work","button_location":"profile"}" 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enormous potential to understand the complexity of human brain aging and neurodegenerative diseases. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588306"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588306/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries"><img alt="Research paper thumbnail of Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries" class="work-thumbnail" src="https://attachments.academia-assets.com/109083249/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588306/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries">Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries</a></div><div class="wp-workCard_item"><span>BMJ Open</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. In this article we investigate complementary aspects of the amlodipine and captopril samples so to explain the previously observed low assays for these two drugs.DesignPost hoc analysis of the captopril and amlodipine drugs samples and their packages collected in the context of the SEVEN study.Setting10 countries were concerned: Benin, Burkina Faso, Congo, Democratic Republic of the Congo, Guinea, Côte d’Ivoire, Mauritania, Niger, Senegal and Togo.ParticipantsLocal scientists and hospital practitioners collected the drug samples in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7702779c6d346de844994193cb571f07" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083249,"asset_id":111588306,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083249/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588306; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588306]").text(description); $(".js-view-count[data-work-id=111588306]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588306; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588306']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588306, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7702779c6d346de844994193cb571f07" } } $('.js-work-strip[data-work-id=111588306]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588306,"title":"Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries","translated_title":"","metadata":{"abstract":"ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588218"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588218/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament"><img alt="Research paper thumbnail of Management des risques appliqué au développement pharmaceutique du médicament" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588218/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament">Management des risques appliqué au développement pharmaceutique du médicament</a></div><div class="wp-workCard_item"><span>Médicaments et produits pharmaceutiques</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cad...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d&#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588218"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588218"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588218; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588218]").text(description); $(".js-view-count[data-work-id=111588218]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588218; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588218']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588218, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588218]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588218,"title":"Management des risques appliqué au développement pharmaceutique du médicament","translated_title":"","metadata":{"abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.","publisher":"Editions Techniques de l Ingenieur","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Médicaments et produits pharmaceutiques"},"translated_abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.","internal_url":"https://www.academia.edu/111588218/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament","translated_internal_url":"","created_at":"2023-12-16T13:43:07.056-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Management_des_risques_appliqué_au_développement_pharmaceutique_du_médicament","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":951,"name":"Humanities","url":"https://www.academia.edu/Documents/in/Humanities"},{"id":4486,"name":"Political Science","url":"https://www.academia.edu/Documents/in/Political_Science"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588193"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588193/Etude_de_biocompatibilit%C3%A9_des_films_%C3%A0_base_de_COC_en_tant_que_mat%C3%A9riaux_implantables"><img alt="Research paper thumbnail of Etude de biocompatibilité des films à base de COC en tant que matériaux implantables" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588193/Etude_de_biocompatibilit%C3%A9_des_films_%C3%A0_base_de_COC_en_tant_que_mat%C3%A9riaux_implantables">Etude de biocompatibilité des films à base de COC en tant que matériaux implantables</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, af...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, afin d’evaluer leur potentiel de biomateriaux implantables.Cette evaluation est realisee par le suivi de plusieurs parametres : viabilite cellulaire/cytotoxicite, evaluation des phenomenes de stress oxydant, inflammatoires et hemocompatibilite. Une relation entre ces reponses biologiques et les proprietes physico chimiques des materiaux etudies a ete apprehendee.Les resultats montrent une bonne biocompatibilite des films testes avec un impact significatif de la presence des additifs (anti-oxydant et lubrifiant) sur les parametres biologiques et physico-chimiques evalues.L’effet simule du vieillissement biologique de ces materiaux sur leur biocompatibilite et leurs caracteres physico-chimiques a egalement ete etudie. Des conditions de pH et d’oxydation extremes, ainsi que le contact avec des macrophages pendant 1 mois, ont un effet sur la surface et sur l’interaction des films de COC avec l’environnement biologique sans compromettre leur biocompatbilite. La presence d’additifs a egalement eu un impact sur ces modifications.En suivant une logique de management du risque, la systematisation de l’ensemble des methodes developpees a permis d’obtenir une approche simplifiee et validee au sein du laboratoire, applicable a l’ensemble des materiaux naturels ou synthetiques susceptibles d’etre utilises dans la fabrication des DM implantables</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588193"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588193"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588193; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588193]").text(description); $(".js-view-count[data-work-id=111588193]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588193; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588193']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588193, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588193]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588193,"title":"Etude de biocompatibilité des films à base de COC en tant que matériaux implantables","translated_title":"","metadata":{"abstract":"L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, afin d’evaluer leur potentiel de biomateriaux implantables.Cette evaluation est realisee par le suivi de plusieurs parametres : viabilite cellulaire/cytotoxicite, evaluation des phenomenes de stress oxydant, inflammatoires et hemocompatibilite. Une relation entre ces reponses biologiques et les proprietes physico chimiques des materiaux etudies a ete apprehendee.Les resultats montrent une bonne biocompatibilite des films testes avec un impact significatif de la presence des additifs (anti-oxydant et lubrifiant) sur les parametres biologiques et physico-chimiques evalues.L’effet simule du vieillissement biologique de ces materiaux sur leur biocompatibilite et leurs caracteres physico-chimiques a egalement ete etudie. Des conditions de pH et d’oxydation extremes, ainsi que le contact avec des macrophages pendant 1 mois, ont un effet sur la surface et sur l’interaction des films de COC avec l’environnement biologique sans compromettre leur biocompatbilite. La presence d’additifs a egalement eu un impact sur ces modifications.En suivant une logique de management du risque, la systematisation de l’ensemble des methodes developpees a permis d’obtenir une approche simplifiee et validee au sein du laboratoire, applicable a l’ensemble des materiaux naturels ou synthetiques susceptibles d’etre utilises dans la fabrication des DM implantables","publication_date":{"day":27,"month":11,"year":2018,"errors":{}}},"translated_abstract":"L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, afin d’evaluer leur potentiel de biomateriaux implantables.Cette evaluation est realisee par le suivi de plusieurs parametres : viabilite cellulaire/cytotoxicite, evaluation des phenomenes de stress oxydant, inflammatoires et hemocompatibilite. Une relation entre ces reponses biologiques et les proprietes physico chimiques des materiaux etudies a ete apprehendee.Les resultats montrent une bonne biocompatibilite des films testes avec un impact significatif de la presence des additifs (anti-oxydant et lubrifiant) sur les parametres biologiques et physico-chimiques evalues.L’effet simule du vieillissement biologique de ces materiaux sur leur biocompatibilite et leurs caracteres physico-chimiques a egalement ete etudie. Des conditions de pH et d’oxydation extremes, ainsi que le contact avec des macrophages pendant 1 mois, ont un effet sur la surface et sur l’interaction des films de COC avec l’environnement biologique sans compromettre leur biocompatbilite. La presence d’additifs a egalement eu un impact sur ces modifications.En suivant une logique de management du risque, la systematisation de l’ensemble des methodes developpees a permis d’obtenir une approche simplifiee et validee au sein du laboratoire, applicable a l’ensemble des materiaux naturels ou synthetiques susceptibles d’etre utilises dans la fabrication des DM implantables","internal_url":"https://www.academia.edu/111588193/Etude_de_biocompatibilit%C3%A9_des_films_%C3%A0_base_de_COC_en_tant_que_mat%C3%A9riaux_implantables","translated_internal_url":"","created_at":"2023-12-16T13:42:35.710-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Etude_de_biocompatibilité_des_films_à_base_de_COC_en_tant_que_matériaux_implantables","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"}],"urls":[{"id":37213433,"url":"http://www.theses.fr/s142458"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588192/LES_ALIMENTS_TRADITIONNELS_REM%C3%88DES_DE_BONNE_FEMME_OU_PHARMACOP%C3%89E_DU_e_SI%C3%88CLE"><img alt="Research paper thumbnail of LES ALIMENTS TRADITIONNELS : REMÈDES DE BONNE FEMME OU PHARMACOPÉE DU e SIÈCLE" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588192/LES_ALIMENTS_TRADITIONNELS_REM%C3%88DES_DE_BONNE_FEMME_OU_PHARMACOP%C3%89E_DU_e_SI%C3%88CLE">LES ALIMENTS TRADITIONNELS : REMÈDES DE BONNE FEMME OU PHARMACOPÉE DU e SIÈCLE</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hund...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hundreds of years as a spice and in traditional medicine. Indeed, this molecule possesses anti-inflammatory and anti-cancer properties after oral or topical administration. In addition to its antioxidant power, curcumin also acts on several cell signalling pathways, various enzymes, the immune system, the atherosclerosis process, angiogenesis and cell adhesion. Its effects on gene transcription or on the induction of apoptosis seem to be particularly promising for use in cancer chemoprevention and chemotherapy in patients. Phase I clinical trials did not show any toxic effect of curcumin, even at high dosages, but phase II clinical studies will be needed to confirm these positive preclinical results. Phytochemicals derived from dietary components or plants traditionally used to combat human diseases remain topical as potential medicines, with scientific and molecular confirmation of their biological activities. Consequently, the regulations governing the use of molecules such as curcumin need to be clarified.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588192]").text(description); $(".js-view-count[data-work-id=111588192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588192, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588192,"title":"LES ALIMENTS TRADITIONNELS : REMÈDES DE BONNE FEMME OU PHARMACOPÉE DU e SIÈCLE","translated_title":"","metadata":{"abstract":"ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hundreds of years as a spice and in traditional medicine. Indeed, this molecule possesses anti-inflammatory and anti-cancer properties after oral or topical administration. In addition to its antioxidant power, curcumin also acts on several cell signalling pathways, various enzymes, the immune system, the atherosclerosis process, angiogenesis and cell adhesion. Its effects on gene transcription or on the induction of apoptosis seem to be particularly promising for use in cancer chemoprevention and chemotherapy in patients. Phase I clinical trials did not show any toxic effect of curcumin, even at high dosages, but phase II clinical studies will be needed to confirm these positive preclinical results. Phytochemicals derived from dietary components or plants traditionally used to combat human diseases remain topical as potential medicines, with scientific and molecular confirmation of their biological activities. Consequently, the regulations governing the use of molecules such as curcumin need to be clarified.","publication_date":{"day":16,"month":2,"year":2008,"errors":{}}},"translated_abstract":"ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hundreds of years as a spice and in traditional medicine. Indeed, this molecule possesses anti-inflammatory and anti-cancer properties after oral or topical administration. In addition to its antioxidant power, curcumin also acts on several cell signalling pathways, various enzymes, the immune system, the atherosclerosis process, angiogenesis and cell adhesion. Its effects on gene transcription or on the induction of apoptosis seem to be particularly promising for use in cancer chemoprevention and chemotherapy in patients. Phase I clinical trials did not show any toxic effect of curcumin, even at high dosages, but phase II clinical studies will be needed to confirm these positive preclinical results. Phytochemicals derived from dietary components or plants traditionally used to combat human diseases remain topical as potential medicines, with scientific and molecular confirmation of their biological activities. Consequently, the regulations governing the use of molecules such as curcumin need to be clarified.","internal_url":"https://www.academia.edu/111588192/LES_ALIMENTS_TRADITIONNELS_REM%C3%88DES_DE_BONNE_FEMME_OU_PHARMACOP%C3%89E_DU_e_SI%C3%88CLE","translated_internal_url":"","created_at":"2023-12-16T13:42:35.579-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"LES_ALIMENTS_TRADITIONNELS_REMÈDES_DE_BONNE_FEMME_OU_PHARMACOPÉE_DU_e_SIÈCLE","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":951,"name":"Humanities","url":"https://www.academia.edu/Documents/in/Humanities"}],"urls":[{"id":37213432,"url":"https://www.em-consulte.com/en/article/79129"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588191"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588191/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs"><img alt="Research paper thumbnail of Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs" class="work-thumbnail" src="https://attachments.academia-assets.com/109083185/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588191/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs">Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs</a></div><div class="wp-workCard_item"><span>Journal of Separation Science</span><span>, Jan 19, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ad9ab0ac15839f857ef5bf013f4d1bd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083185,"asset_id":111588191,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083185/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588191; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588191]").text(description); $(".js-view-count[data-work-id=111588191]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588191; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588191']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588191, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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Proteomics has an important role in these investigations because of its unique strengths and because of the potential central pathogenic contribution of pathological protein to several of these diseases. Here we have reviewed the methods and presented some examples of liquid chromatography-electrospray ionization-tandem mass spectrometry-based proteomics, with and without quantification using isotope-coded affinity tags, in the investigation of aging and Alzheimer's disease. As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases.","publication_date":{"day":19,"month":1,"year":2015,"errors":{}},"publication_name":"Journal of Separation Science","grobid_abstract_attachment_id":109083185},"translated_abstract":null,"internal_url":"https://www.academia.edu/111588191/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs","translated_internal_url":"","created_at":"2023-12-16T13:42:35.446-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":109083185,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083185/thumbnails/1.jpg","file_name":"j.nurx.2006.05.00220231216-1-za3m4y.pdf","download_url":"https://www.academia.edu/attachments/109083185/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Liquid_chromatography_with_tandem_mass_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083185/j.nurx.2006.05.00220231216-1-za3m4y-libre.pdf?1702763237=\u0026response-content-disposition=attachment%3B+filename%3DLiquid_chromatography_with_tandem_mass_s.pdf\u0026Expires=1732811388\u0026Signature=eyCq9SQbra4yzHO5OgzvM6PgwGBrRlu428uAnxVHPWr1N2wuWLzTgyrJdD9UG-yfjLCMLFvvaZ0MUu0HF5HSdE8fCJXfuYGq3gUZi7cde2wPyiMV928euMyc3zQ2AfFznO5O~AoVdDUDOA2605prwXYQhBu-MUFew9Wvuflz1L4Thl623N0-QAJkrJLSEL9POcYwLQfWfu4NgH77k6oOS8evQ3EouHneFlG-1XtRmyJUJsp45X7oSh2cdPkFQQUpwai6o6Mtinic45oWR8AlrwtXJww1jrV9Fg-pxwLyBCdEsoPb7HPYHCvjW6xhM4Q9U7It5rrG592fd7cE6xJpCg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[{"id":109083185,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083185/thumbnails/1.jpg","file_name":"j.nurx.2006.05.00220231216-1-za3m4y.pdf","download_url":"https://www.academia.edu/attachments/109083185/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Liquid_chromatography_with_tandem_mass_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083185/j.nurx.2006.05.00220231216-1-za3m4y-libre.pdf?1702763237=\u0026response-content-disposition=attachment%3B+filename%3DLiquid_chromatography_with_tandem_mass_s.pdf\u0026Expires=1732811388\u0026Signature=eyCq9SQbra4yzHO5OgzvM6PgwGBrRlu428uAnxVHPWr1N2wuWLzTgyrJdD9UG-yfjLCMLFvvaZ0MUu0HF5HSdE8fCJXfuYGq3gUZi7cde2wPyiMV928euMyc3zQ2AfFznO5O~AoVdDUDOA2605prwXYQhBu-MUFew9Wvuflz1L4Thl623N0-QAJkrJLSEL9POcYwLQfWfu4NgH77k6oOS8evQ3EouHneFlG-1XtRmyJUJsp45X7oSh2cdPkFQQUpwai6o6Mtinic45oWR8AlrwtXJww1jrV9Fg-pxwLyBCdEsoPb7HPYHCvjW6xhM4Q9U7It5rrG592fd7cE6xJpCg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry"},{"id":4527,"name":"Africa","url":"https://www.academia.edu/Documents/in/Africa"},{"id":4656,"name":"Chromatography","url":"https://www.academia.edu/Documents/in/Chromatography"},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":67215,"name":"Separation Science","url":"https://www.academia.edu/Documents/in/Separation_Science"},{"id":163275,"name":"Tandem Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Tandem_Mass_Spectrometry"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography"}],"urls":[{"id":37213431,"url":"https://doi.org/10.1002/jssc.201401301"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588190/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries"><img alt="Research paper thumbnail of Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries" class="work-thumbnail" src="https://attachments.academia-assets.com/109083184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588190/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries">Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries</a></div><div class="wp-workCard_item"><span>BMJ Open</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. In this article we investigate complementary aspects of the amlodipine and captopril samples so to explain the previously observed low assays for these two drugs.DesignPost hoc analysis of the captopril and amlodipine drugs samples and their packages collected in the context of the SEVEN study.Setting10 countries were concerned: Benin, Burkina Faso, Congo, Democratic Republic of the Congo, Guinea, Côte d’Ivoire, Mauritania, Niger, Senegal and Togo.ParticipantsLocal scientists and hospital practitioners collected the drug samples in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5bf1ce5c07c44fbc8fa1a55f070d8cb1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083184,"asset_id":111588190,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083184/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588190]").text(description); $(".js-view-count[data-work-id=111588190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588190, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5bf1ce5c07c44fbc8fa1a55f070d8cb1" } } $('.js-work-strip[data-work-id=111588190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588190,"title":"Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries","translated_title":"","metadata":{"abstract":"ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. 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In this article we investigate complementary aspects of the amlodipine and captopril samples so to explain the previously observed low assays for these two drugs.DesignPost hoc analysis of the captopril and amlodipine drugs samples and their packages collected in the context of the SEVEN study.Setting10 countries were concerned: Benin, Burkina Faso, Congo, Democratic Republic of the Congo, Guinea, Côte d’Ivoire, Mauritania, Niger, Senegal and Togo.ParticipantsLocal scientists and hospital practitioners collected the drug samples in...","publisher":"BMJ","ai_title_tag":"Investigation of Low Quality Cardiovascular Medicines in Africa","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"BMJ Open"},"translated_abstract":"ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588189/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament"><img alt="Research paper thumbnail of Management des risques appliqué au développement pharmaceutique du médicament" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588189/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament">Management des risques appliqué au développement pharmaceutique du médicament</a></div><div class="wp-workCard_item"><span>Médicaments et produits pharmaceutiques</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cad...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d&#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588189; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588189]").text(description); $(".js-view-count[data-work-id=111588189]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588189; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588189']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588189, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588189,"title":"Management des risques appliqué au développement pharmaceutique du médicament","translated_title":"","metadata":{"abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.","publisher":"Editions Techniques de l Ingenieur","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Médicaments et produits pharmaceutiques"},"translated_abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. 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C, Materials for biological applications</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d037a3993b39bd4b25d5f33b0ccab97" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083182,"asset_id":111588188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083182/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588188]").text(description); $(".js-view-count[data-work-id=111588188]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588188']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588188, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d037a3993b39bd4b25d5f33b0ccab97" } } $('.js-work-strip[data-work-id=111588188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588188,"title":"Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing","translated_title":"","metadata":{"abstract":"Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588185"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588185/Characterization_of_the_surface_physico_chemistry_of_plasticized_PVC_used_in_blood_bag_and_infusion_tubing"><img alt="Research paper thumbnail of Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing" class="work-thumbnail" src="https://attachments.academia-assets.com/109083177/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588185/Characterization_of_the_surface_physico_chemistry_of_plasticized_PVC_used_in_blood_bag_and_infusion_tubing">Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing</a></div><div class="wp-workCard_item"><span>Materials science & engineering. C, Materials for biological applications</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="afc1281cd06bc8963db4029ce2c9fe06" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083177,"asset_id":111588185,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083177/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588185"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588185; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588185]").text(description); $(".js-view-count[data-work-id=111588185]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588185; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588185']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588185, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "afc1281cd06bc8963db4029ce2c9fe06" } } $('.js-work-strip[data-work-id=111588185]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588185,"title":"Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing","translated_title":"","metadata":{"abstract":"Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Materials science \u0026 engineering. C, Materials for biological applications"},"translated_abstract":"Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.","internal_url":"https://www.academia.edu/111588185/Characterization_of_the_surface_physico_chemistry_of_plasticized_PVC_used_in_blood_bag_and_infusion_tubing","translated_internal_url":"","created_at":"2023-12-16T13:42:17.677-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":109083177,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083177/thumbnails/1.jpg","file_name":"j.msec.2017.02.05720231216-1-p2mj1p.pdf","download_url":"https://www.academia.edu/attachments/109083177/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterization_of_the_surface_physico.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083177/j.msec.2017.02.05720231216-1-p2mj1p-libre.pdf?1702763255=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_the_surface_physico.pdf\u0026Expires=1732811388\u0026Signature=Ykcg4Sz558Vlw-jh44EvL4qRYS3oMLzAFeibJx6I41wyguvG9Jebq8cKFouJxpur0-y2VkXREPrXLINHlm~BbjG71FJLIblqifImsnRv4NJd~lGsPcUd7itceV5ZlXhVFrz8gjgpRUTBexTHqVAzAKhidxY2mlKwjTJyj6V-8ppYVjm3sxQ9KovdFbXZoyaqvqvHxy9vkztUGflVUmuOMIMkOBnpeK1TmQHdWEZMa-JuRn7NmuWzaFd7~bkquVLoJLFIXtPWBt2zL4zXutRQ20fzW8hxhwOSTohOdpW6xFaAL~Z962lEsD0vBDMTHrqUR6NpQRussKuVpkxip0QBdA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Characterization_of_the_surface_physico_chemistry_of_plasticized_PVC_used_in_blood_bag_and_infusion_tubing","translated_slug":"","page_count":58,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[{"id":109083177,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083177/thumbnails/1.jpg","file_name":"j.msec.2017.02.05720231216-1-p2mj1p.pdf","download_url":"https://www.academia.edu/attachments/109083177/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Characterization_of_the_surface_physico.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083177/j.msec.2017.02.05720231216-1-p2mj1p-libre.pdf?1702763255=\u0026response-content-disposition=attachment%3B+filename%3DCharacterization_of_the_surface_physico.pdf\u0026Expires=1732811388\u0026Signature=Ykcg4Sz558Vlw-jh44EvL4qRYS3oMLzAFeibJx6I41wyguvG9Jebq8cKFouJxpur0-y2VkXREPrXLINHlm~BbjG71FJLIblqifImsnRv4NJd~lGsPcUd7itceV5ZlXhVFrz8gjgpRUTBexTHqVAzAKhidxY2mlKwjTJyj6V-8ppYVjm3sxQ9KovdFbXZoyaqvqvHxy9vkztUGflVUmuOMIMkOBnpeK1TmQHdWEZMa-JuRn7NmuWzaFd7~bkquVLoJLFIXtPWBt2zL4zXutRQ20fzW8hxhwOSTohOdpW6xFaAL~Z962lEsD0vBDMTHrqUR6NpQRussKuVpkxip0QBdA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":72,"name":"Chemical Engineering","url":"https://www.academia.edu/Documents/in/Chemical_Engineering"},{"id":511,"name":"Materials Science","url":"https://www.academia.edu/Documents/in/Materials_Science"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":58527,"name":"Polymer","url":"https://www.academia.edu/Documents/in/Polymer"},{"id":133994,"name":"Lubricant","url":"https://www.academia.edu/Documents/in/Lubricant"},{"id":325874,"name":"PVC","url":"https://www.academia.edu/Documents/in/PVC"},{"id":414543,"name":"Lubricants Additives","url":"https://www.academia.edu/Documents/in/Lubricants_Additives"},{"id":627890,"name":"Blood Transfusion","url":"https://www.academia.edu/Documents/in/Blood_Transfusion"},{"id":876112,"name":"Infusion","url":"https://www.academia.edu/Documents/in/Infusion"},{"id":903768,"name":"Plasticizer","url":"https://www.academia.edu/Documents/in/Plasticizer"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588158/Phototransformation_patterns_of_the_antiplatelet_drug_tirofiban_in_aqueous_solution_relevant_to_drug_delivery_and_storage"><img alt="Research paper thumbnail of Phototransformation patterns of the antiplatelet drug tirofiban in aqueous solution, relevant to drug delivery and storage" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588158/Phototransformation_patterns_of_the_antiplatelet_drug_tirofiban_in_aqueous_solution_relevant_to_drug_delivery_and_storage">Phototransformation patterns of the antiplatelet drug tirofiban in aqueous solution, relevant to drug delivery and storage</a></div><div class="wp-workCard_item"><span>New Journal of Chemistry</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions and the photoproducts formed are not structurally alerting for genotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588158; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87212306"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87212306/PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study"><img alt="Research paper thumbnail of PH002: Cardiovascular drugs poor quality and mortality in 10sub-saharan countries: the SEVEN study" class="work-thumbnail" src="https://attachments.academia-assets.com/91486053/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87212306/PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study">PH002: Cardiovascular drugs poor quality and mortality in 10sub-saharan countries: the SEVEN study</a></div><div class="wp-workCard_item"><span>International Journal of Clinical Pharmacy</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eace35ab2e0ff77ce9816ffbacd27990" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91486053,"asset_id":87212306,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91486053/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87212306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87212306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87212306; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87212306]").text(description); $(".js-view-count[data-work-id=87212306]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87212306; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87212306']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87212306, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eace35ab2e0ff77ce9816ffbacd27990" } } $('.js-work-strip[data-work-id=87212306]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87212306,"title":"PH002: Cardiovascular drugs poor quality and mortality in 10sub-saharan countries: the SEVEN study","translated_title":"","metadata":{"publisher":"International Journal of Clinical Pharmacy","grobid_abstract":"Background and objective: Streptococcus pyogenes is an aerobic, gram-positive extracellular bacterium responsible for a wide variety of infections. Its subtype, group A (b-haemolytic) strep (GAS) causes common pharyngitis (also known as ''strep throat''). Novel rapid antigen detection tests allow for diagnosis of Group A Strep at the point-of-care and are ideally suited for use by community pharmacists. The objective of the study is to evaluate the impact and feasibility of community pharmacist-directed GAS testing. Setting and method: A retrospective analysis of aggregate billing data was conducted using descriptive statistics to evaluate the effectiveness of a community pharmacist-directed strep testing program at Shoppers Drug Mart pharmacies in the Canadian provinces of British Columbia, Alberta, and Nova Scotia. Pharmacists trained in sample collection offered the screening to patients with symptoms suggestive of Strep from November 28, 2015 to May 31, 2016. Throat swabs were collected and analysed using the BD Veritor TM system for rapid detection of GAS. Main outcome measures: Proportion of GAS-positive cases that resulted in the same day initiation of antibiotic therapy by pharmacists. Results: 7050 patients were tested across 204 participating locations. Average age was 27.3 years with children (5-14) representing 30.7% of the population. 25.5% of patients tested positive for GAS. Of the patients who screened positive, antibiotic therapy was initiated within the same day in 68.7% of cases. In Alberta, where pharmacists have advanced prescribing authority, same day initiation of therapy was 73.8% compared to a rate of 40.5% (p \\ 0.0001) in the other jurisdictions. Conclusion: These results highlight both the public readiness to access point of care services in community pharmacies and the ability of pharmacists to conveniently expedite management of patients with GAS. Community pharmacy-based Strep testing can facilitate prompt and appropriate access to antibiotic therapy as was demonstrated in those regions with advanced prescribing authority. Communication of recommendations to the physician in a timely manner remains a barrier to accessing treatment in those regions without this additional scope of practice. CP-PC002: Influence of physicians' beliefs about statins on patients' beliefs and adherence on statin therapy","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"International Journal of Clinical Pharmacy","grobid_abstract_attachment_id":91486053},"translated_abstract":null,"internal_url":"https://www.academia.edu/87212306/PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study","translated_internal_url":"","created_at":"2022-09-24T09:11:31.747-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":91486053,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91486053/thumbnails/1.jpg","file_name":"pmc7089505.pdf","download_url":"https://www.academia.edu/attachments/91486053/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"PH002_Cardiovascular_drugs_poor_quality.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91486053/pmc7089505-libre.pdf?1664036967=\u0026response-content-disposition=attachment%3B+filename%3DPH002_Cardiovascular_drugs_poor_quality.pdf\u0026Expires=1732811388\u0026Signature=G8H5iu~o-yMlEKTaKrsy815kqsGbWiVImao7GbKQKfO2eja9p96adAVvZTkey7PZtU2Mh--vdP46wVVWNpGnPqGb0BzSAxT5vanXj-WT4QLmDunKGnZ45NEyhkWkfdv1W8uUtAz0HpuNh78KaCOeUYwByu9WswANiX2bVibPqL5Jvg5-MKc174971H~wRBpSkdvDNMB0coMlpC1CT~fDMTUlmLqBFlN~sZKXhTZhxnkX0GXhFpjcDQH9F-GXUeUgND3kr2GQWu6SCewL9GdgTjnpi8FvDYr6r1h1R9WfNxM7GbdXBa5TMAOtSHn8LmLT-sPHIFI3G~isAX02R9KfqQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study","translated_slug":"","page_count":134,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[{"id":91486053,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91486053/thumbnails/1.jpg","file_name":"pmc7089505.pdf","download_url":"https://www.academia.edu/attachments/91486053/download_file?st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"PH002_Cardiovascular_drugs_poor_quality.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91486053/pmc7089505-libre.pdf?1664036967=\u0026response-content-disposition=attachment%3B+filename%3DPH002_Cardiovascular_drugs_poor_quality.pdf\u0026Expires=1732811388\u0026Signature=G8H5iu~o-yMlEKTaKrsy815kqsGbWiVImao7GbKQKfO2eja9p96adAVvZTkey7PZtU2Mh--vdP46wVVWNpGnPqGb0BzSAxT5vanXj-WT4QLmDunKGnZ45NEyhkWkfdv1W8uUtAz0HpuNh78KaCOeUYwByu9WswANiX2bVibPqL5Jvg5-MKc174971H~wRBpSkdvDNMB0coMlpC1CT~fDMTUlmLqBFlN~sZKXhTZhxnkX0GXhFpjcDQH9F-GXUeUgND3kr2GQWu6SCewL9GdgTjnpi8FvDYr6r1h1R9WfNxM7GbdXBa5TMAOtSHn8LmLT-sPHIFI3G~isAX02R9KfqQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389132"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389132/Biocompatibility_of_polymer_based_biomaterials_and_medical_devices_regulations_in_vitro_screening_and_risk_management"><img alt="Research paper thumbnail of Biocompatibility of polymer-based biomaterials and medical devices - regulations, in vitro screening and risk-management" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389132/Biocompatibility_of_polymer_based_biomaterials_and_medical_devices_regulations_in_vitro_screening_and_risk_management">Biocompatibility of polymer-based biomaterials and medical devices - regulations, in vitro screening and risk-management</a></div><div class="wp-workCard_item"><span>Biomaterials science</span><span>, Jan 24, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Biomaterials play an increasing role in modern health care systems. Biocompatibility poses a sign...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Biomaterials play an increasing role in modern health care systems. Biocompatibility poses a significant challenge for manufacturers of medical devices and contemporary intelligent drug delivery technologies from materials development to market approval. Despite a highly regulated environment, biocompatibility evaluation of biomaterials for medical devices is a complex task related to various factors that include mainly chemical nature and physical properties of the material, the contact tissue and duration of contact. Although international standards, such as ISO 10993-1, are generally employed to prove regulatory compliance needed for market clearance or for initiating clinical investigations, they may not offer sufficient guidance, or risk-management perspective when it comes to choosing materials or appropriate in vitro biocompatibility screening methods when developing medical devices. The global normative approach towards the biocompatibility evaluation of medical devices is p...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389132"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389132"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389132; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389132]").text(description); $(".js-view-count[data-work-id=74389132]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389132; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389132']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389132, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389132]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389132,"title":"Biocompatibility of polymer-based biomaterials and medical devices - regulations, in vitro screening and risk-management","translated_title":"","metadata":{"abstract":"Biomaterials play an increasing role in modern health care systems. 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Although international standards, such as ISO 10993-1, are generally employed to prove regulatory compliance needed for market clearance or for initiating clinical investigations, they may not offer sufficient guidance, or risk-management perspective when it comes to choosing materials or appropriate in vitro biocompatibility screening methods when developing medical devices. The global normative approach towards the biocompatibility evaluation of medical devices is p...","internal_url":"https://www.academia.edu/74389132/Biocompatibility_of_polymer_based_biomaterials_and_medical_devices_regulations_in_vitro_screening_and_risk_management","translated_internal_url":"","created_at":"2022-03-23T08:11:15.306-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Biocompatibility_of_polymer_based_biomaterials_and_medical_devices_regulations_in_vitro_screening_and_risk_management","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science"},{"id":2698,"name":"Biomaterials","url":"https://www.academia.edu/Documents/in/Biomaterials"},{"id":12061,"name":"Risk Management","url":"https://www.academia.edu/Documents/in/Risk_Management"},{"id":21466,"name":"Polymers","url":"https://www.academia.edu/Documents/in/Polymers"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":234503,"name":"Biomaterials Science","url":"https://www.academia.edu/Documents/in/Biomaterials_Science"},{"id":816902,"name":"In-vitro Biocompatibility Test","url":"https://www.academia.edu/Documents/in/In-vitro_Biocompatibility_Test"},{"id":1031067,"name":"Biocompatible Materials","url":"https://www.academia.edu/Documents/in/Biocompatible_Materials"},{"id":1286978,"name":"Equipment and Supplies","url":"https://www.academia.edu/Documents/in/Equipment_and_Supplies"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389131"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389131/Biocompatibility_assessment_of_cyclic_olefin_copolymers_Impact_of_two_additives_on_cytotoxicity_oxidative_stress_inflammatory_reactions_and_hemocompatibility"><img alt="Research paper thumbnail of Biocompatibility assessment of cyclic olefin copolymers: Impact of two additives on cytotoxicity, oxidative stress, inflammatory reactions and hemocompatibility" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389131/Biocompatibility_assessment_of_cyclic_olefin_copolymers_Impact_of_two_additives_on_cytotoxicity_oxidative_stress_inflammatory_reactions_and_hemocompatibility">Biocompatibility assessment of cyclic olefin copolymers: Impact of two additives on cytotoxicity, oxidative stress, inflammatory reactions and hemocompatibility</a></div><div class="wp-workCard_item"><span>Journal of biomedical materials research. Part A</span><span>, Jan 5, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility. The cytotoxicity was evaluated according to ISO 10993-5 guidelines using L929 fibroblasts, HUVEC and THP-1-derived macrophages. Oxidative stress (ROS, GSH/GSSG and SOD analysis) and pro-inflammatory cytokines (Il-6 and TNF-α secretion) were quantified using THP-1 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion and activation (membranous P-selectin expression). Results show that the different types of COC have successfully passed the in vitro biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably li...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389131"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389131"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389131; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389131]").text(description); $(".js-view-count[data-work-id=74389131]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389131; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389131']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389131, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389131]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389131,"title":"Biocompatibility assessment of cyclic olefin copolymers: Impact of two additives on cytotoxicity, oxidative stress, inflammatory reactions and hemocompatibility","translated_title":"","metadata":{"abstract":"This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility. The cytotoxicity was evaluated according to ISO 10993-5 guidelines using L929 fibroblasts, HUVEC and THP-1-derived macrophages. Oxidative stress (ROS, GSH/GSSG and SOD analysis) and pro-inflammatory cytokines (Il-6 and TNF-α secretion) were quantified using THP-1 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion and activation (membranous P-selectin expression). Results show that the different types of COC have successfully passed the in vitro biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably li...","publication_date":{"day":5,"month":1,"year":2017,"errors":{}},"publication_name":"Journal of biomedical materials research. Part A"},"translated_abstract":"This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility. The cytotoxicity was evaluated according to ISO 10993-5 guidelines using L929 fibroblasts, HUVEC and THP-1-derived macrophages. Oxidative stress (ROS, GSH/GSSG and SOD analysis) and pro-inflammatory cytokines (Il-6 and TNF-α secretion) were quantified using THP-1 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion and activation (membranous P-selectin expression). Results show that the different types of COC have successfully passed the in vitro biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably li...","internal_url":"https://www.academia.edu/74389131/Biocompatibility_assessment_of_cyclic_olefin_copolymers_Impact_of_two_additives_on_cytotoxicity_oxidative_stress_inflammatory_reactions_and_hemocompatibility","translated_internal_url":"","created_at":"2022-03-23T08:11:15.216-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Biocompatibility_assessment_of_cyclic_olefin_copolymers_Impact_of_two_additives_on_cytotoxicity_oxidative_stress_inflammatory_reactions_and_hemocompatibility","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":57799,"name":"Biocompatibility","url":"https://www.academia.edu/Documents/in/Biocompatibility"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":189424,"name":"Blood Coagulation","url":"https://www.academia.edu/Documents/in/Blood_Coagulation"},{"id":209508,"name":"Platelet activation mechanism","url":"https://www.academia.edu/Documents/in/Platelet_activation_mechanism"},{"id":246971,"name":"Olefin Polymerization","url":"https://www.academia.edu/Documents/in/Olefin_Polymerization"},{"id":892969,"name":"Materials Testing","url":"https://www.academia.edu/Documents/in/Materials_Testing"},{"id":1031067,"name":"Biocompatible Materials","url":"https://www.academia.edu/Documents/in/Biocompatible_Materials"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1900203,"name":"Hemolysis","url":"https://www.academia.edu/Documents/in/Hemolysis"},{"id":3802434,"name":"Human Umbilical Vein Endothelial Cells","url":"https://www.academia.edu/Documents/in/Human_Umbilical_Vein_Endothelial_Cells"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389130"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389130/Fighting_fake_medicines_First_quality_evaluation_of_cardiac_drugs_in_Africa"><img alt="Research paper thumbnail of Fighting fake medicines: First quality evaluation of cardiac drugs in Africa" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389130/Fighting_fake_medicines_First_quality_evaluation_of_cardiac_drugs_in_Africa">Fighting fake medicines: First quality evaluation of cardiac drugs in Africa</a></div><div class="wp-workCard_item"><span>International journal of cardiology</span><span>, Jan 19, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The growing menace of poor quality and falsified drugs constitutes a major hazard, compromising h...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The growing menace of poor quality and falsified drugs constitutes a major hazard, compromising healthcare and patient outcomes. Efforts to assess drug standards worldwide have almost exclusively focused on anti-microbial drugs; with no study to date on cardiovascular drugs. Our study aims to assess quality of seven routinely used cardiovascular medications (anticoagulants, antihypertensives and statins) in ten Sub-Saharan African countries. Drugs were prospectively collected using standardized methods between 2012 and 2014 from licensed (random pharmacies) and unlicensed (street-markets) places of sale in Africa. We developed a validated reversed-phase liquid chromatography with tandem mass spectrometry method to accurately quantify the active ingredient in a certified public laboratory. 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Chem.</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions and the photoproducts formed are not structurally alerting for genotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389129"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389129"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389129; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389129]").text(description); $(".js-view-count[data-work-id=74389129]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389129; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389129']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389129, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389129]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389129,"title":"Phototransformation-Pattern of Antiplatelet Drug Tirofiban in Aqueous Solution, Relevant To Drug Delivery and Storage","translated_title":"","metadata":{"abstract":"Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions and the photoproducts formed are not structurally alerting for genotoxicity.","publisher":"Royal Society of Chemistry (RSC)","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"New J. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389126/PSY37_Assessment_of_the_Global_Cost_of_Transfusion_in_French_Orthopedic_Surgery_Wards"><img alt="Research paper thumbnail of PSY37 Assessment of the Global Cost of Transfusion in French Orthopedic Surgery Wards" class="work-thumbnail" src="https://attachments.academia-assets.com/82559205/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389126/PSY37_Assessment_of_the_Global_Cost_of_Transfusion_in_French_Orthopedic_Surgery_Wards">PSY37 Assessment of the Global Cost of Transfusion in French Orthopedic Surgery Wards</a></div><div class="wp-workCard_item"><span>Value in Health</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3438c590ca22f084c890e58c9f8409c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82559205,"asset_id":74389126,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82559205/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389126; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389125/Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France"><img alt="Research paper thumbnail of Pharmaceutical Costs of Desensitization Therapy in Patients Awaiting Lung Transplantation in France" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389125/Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France">Pharmaceutical Costs of Desensitization Therapy in Patients Awaiting Lung Transplantation in France</a></div><div class="wp-workCard_item"><span>BioDrugs</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leuko...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leukocyte antigen (HLA) antibodies in patients awaiting lung transplant have recently been developed. The off-label use of high-dose intravenous polyvalent immunoglobulins (IVIg) and/or plasmapheresis changes the economical weight of pharmaceutical cost before lung transplantation. Our objective was to assess the budgetary impact of pharmaceutical costs of desensitization therapy. Two observational studies were conducted in 2009 and 2010 at the Bichat Claude Bernard (BCB) hospital in France. The first assessed the real pharmaceutical costs, and identified cost drivers, of desensitized (D+) patients awaiting lung transplantation. The second compared pharmaceutical and clinical data between D+ and non-treated (D-) patients. The major cost drivers were IVIg, representing 89.7 % of pharmaceutical costs. The real cost of drugs was €4,392 ± 647 per hospitalization. Mean hospitalization and annual pharmaceutical costs per patient were significantly higher for D+ than for D- patients (€6,972 vs. 2,925 and €13,074 vs. 399). D+ patients had a significantly higher average number of annual hospitalizations than did D- patients. Total IVIg costs represented 98 % of the pharmaceutical costs for desensitization stays. Pharmaceutical costs represented 40 % of total hospitalization costs for D+ versus only 7 % for D-. New desensitization protocols can help to manage the immunological hurdle of anti-donor antibodies in lung transplantation. They are expensive and not yet correctly covered by national health insurance, as they are supported by hospital budgets. A medico-economical evaluation of IVIg use in this indication seems necessary.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389125]").text(description); $(".js-view-count[data-work-id=74389125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389125, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389125,"title":"Pharmaceutical Costs of Desensitization Therapy in Patients Awaiting Lung Transplantation in France","translated_title":"","metadata":{"abstract":"Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leukocyte antigen (HLA) antibodies in patients awaiting lung transplant have recently been developed. The off-label use of high-dose intravenous polyvalent immunoglobulins (IVIg) and/or plasmapheresis changes the economical weight of pharmaceutical cost before lung transplantation. Our objective was to assess the budgetary impact of pharmaceutical costs of desensitization therapy. Two observational studies were conducted in 2009 and 2010 at the Bichat Claude Bernard (BCB) hospital in France. The first assessed the real pharmaceutical costs, and identified cost drivers, of desensitized (D+) patients awaiting lung transplantation. The second compared pharmaceutical and clinical data between D+ and non-treated (D-) patients. The major cost drivers were IVIg, representing 89.7 % of pharmaceutical costs. The real cost of drugs was €4,392 ± 647 per hospitalization. Mean hospitalization and annual pharmaceutical costs per patient were significantly higher for D+ than for D- patients (€6,972 vs. 2,925 and €13,074 vs. 399). D+ patients had a significantly higher average number of annual hospitalizations than did D- patients. Total IVIg costs represented 98 % of the pharmaceutical costs for desensitization stays. Pharmaceutical costs represented 40 % of total hospitalization costs for D+ versus only 7 % for D-. New desensitization protocols can help to manage the immunological hurdle of anti-donor antibodies in lung transplantation. They are expensive and not yet correctly covered by national health insurance, as they are supported by hospital budgets. A medico-economical evaluation of IVIg use in this indication seems necessary.","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"BioDrugs"},"translated_abstract":"Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leukocyte antigen (HLA) antibodies in patients awaiting lung transplant have recently been developed. The off-label use of high-dose intravenous polyvalent immunoglobulins (IVIg) and/or plasmapheresis changes the economical weight of pharmaceutical cost before lung transplantation. Our objective was to assess the budgetary impact of pharmaceutical costs of desensitization therapy. Two observational studies were conducted in 2009 and 2010 at the Bichat Claude Bernard (BCB) hospital in France. The first assessed the real pharmaceutical costs, and identified cost drivers, of desensitized (D+) patients awaiting lung transplantation. The second compared pharmaceutical and clinical data between D+ and non-treated (D-) patients. The major cost drivers were IVIg, representing 89.7 % of pharmaceutical costs. The real cost of drugs was €4,392 ± 647 per hospitalization. Mean hospitalization and annual pharmaceutical costs per patient were significantly higher for D+ than for D- patients (€6,972 vs. 2,925 and €13,074 vs. 399). D+ patients had a significantly higher average number of annual hospitalizations than did D- patients. Total IVIg costs represented 98 % of the pharmaceutical costs for desensitization stays. Pharmaceutical costs represented 40 % of total hospitalization costs for D+ versus only 7 % for D-. New desensitization protocols can help to manage the immunological hurdle of anti-donor antibodies in lung transplantation. They are expensive and not yet correctly covered by national health insurance, as they are supported by hospital budgets. A medico-economical evaluation of IVIg use in this indication seems necessary.","internal_url":"https://www.academia.edu/74389125/Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France","translated_internal_url":"","created_at":"2022-03-23T08:11:14.669-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":22213,"name":"Pharmacoeconomics","url":"https://www.academia.edu/Documents/in/Pharmacoeconomics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization"},{"id":1221634,"name":"Introvenous Immunoglobulins","url":"https://www.academia.edu/Documents/in/Introvenous_Immunoglobulins"},{"id":2474611,"name":"Costs and Cost Analysis","url":"https://www.academia.edu/Documents/in/Costs_and_Cost_Analysis"},{"id":2731176,"name":"Lung Transplantation","url":"https://www.academia.edu/Documents/in/Lung_Transplantation"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389082"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389082/Identification_of_the_major_degradation_pathways_of_ticagrelor"><img alt="Research paper thumbnail of Identification of the major degradation pathways of ticagrelor" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389082/Identification_of_the_major_degradation_pathways_of_ticagrelor">Identification of the major degradation pathways of ticagrelor</a></div><div class="wp-workCard_item"><span>Journal of Pharmaceutical and Biomedical Analysis</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker u...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker used as antiplatelet drug. Forced degradation under various stress conditions was carried out. The degradation products have been detected and identified by high-pressure liquid chromatography multistage mass spectrometry (LC-MS(n)) along with high-resolution mass spectrometry. C18 XTerra MS column combined with a linear gradient mobile phase composed of a mixture of 10 mM acetate ammonium/acetonitrile was shown suitable for drug and impurity determinations and validated as a stability indicating method. Structural elucidation of the degradation products relied on MS(n) studies and accurate mass measurements giving access to elemental compositions. Up to nine degradation products resulting from oxidation/auto-oxidation, S-dealkylation and N-dealkylation have been identified, covering a range of possible degradation pathways for derivatives with such functional groups. Kinetics was also studied in order to assess the molecule&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s shelf-life and to identify the most important degradation factors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389082"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389082"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389082; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389082]").text(description); $(".js-view-count[data-work-id=74389082]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389082; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389082']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389082, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389082]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389082,"title":"Identification of the major degradation pathways of ticagrelor","translated_title":"","metadata":{"abstract":"Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker used as antiplatelet drug. Forced degradation under various stress conditions was carried out. The degradation products have been detected and identified by high-pressure liquid chromatography multistage mass spectrometry (LC-MS(n)) along with high-resolution mass spectrometry. C18 XTerra MS column combined with a linear gradient mobile phase composed of a mixture of 10 mM acetate ammonium/acetonitrile was shown suitable for drug and impurity determinations and validated as a stability indicating method. Structural elucidation of the degradation products relied on MS(n) studies and accurate mass measurements giving access to elemental compositions. Up to nine degradation products resulting from oxidation/auto-oxidation, S-dealkylation and N-dealkylation have been identified, covering a range of possible degradation pathways for derivatives with such functional groups. Kinetics was also studied in order to assess the molecule\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s shelf-life and to identify the most important degradation factors.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Journal of Pharmaceutical and Biomedical Analysis"},"translated_abstract":"Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker used as antiplatelet drug. Forced degradation under various stress conditions was carried out. The degradation products have been detected and identified by high-pressure liquid chromatography multistage mass spectrometry (LC-MS(n)) along with high-resolution mass spectrometry. C18 XTerra MS column combined with a linear gradient mobile phase composed of a mixture of 10 mM acetate ammonium/acetonitrile was shown suitable for drug and impurity determinations and validated as a stability indicating method. Structural elucidation of the degradation products relied on MS(n) studies and accurate mass measurements giving access to elemental compositions. Up to nine degradation products resulting from oxidation/auto-oxidation, S-dealkylation and N-dealkylation have been identified, covering a range of possible degradation pathways for derivatives with such functional groups. Kinetics was also studied in order to assess the molecule\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s shelf-life and to identify the most important degradation factors.","internal_url":"https://www.academia.edu/74389082/Identification_of_the_major_degradation_pathways_of_ticagrelor","translated_internal_url":"","created_at":"2022-03-23T08:10:35.951-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Identification_of_the_major_degradation_pathways_of_ticagrelor","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry"},{"id":4656,"name":"Chromatography","url":"https://www.academia.edu/Documents/in/Chromatography"},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":623612,"name":"Photolysis","url":"https://www.academia.edu/Documents/in/Photolysis"},{"id":1030794,"name":"Hydrolysis","url":"https://www.academia.edu/Documents/in/Hydrolysis"},{"id":1135814,"name":"Drug Stability","url":"https://www.academia.edu/Documents/in/Drug_Stability"},{"id":1256747,"name":"Oxidation-Reduction","url":"https://www.academia.edu/Documents/in/Oxidation-Reduction"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure"},{"id":3696980,"name":"Platelet Aggregation Inhibitors","url":"https://www.academia.edu/Documents/in/Platelet_Aggregation_Inhibitors"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3988601,"name":"limit of detection","url":"https://www.academia.edu/Documents/in/limit_of_detection"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="1190678" id="papers"><div class="js-work-strip profile--work_container" data-work-id="111588361"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588361/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs"><img alt="Research paper thumbnail of Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs" class="work-thumbnail" src="https://attachments.academia-assets.com/109083302/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588361/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs">Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs</a></div><div class="wp-workCard_item"><span>Journal of Separation Science</span><span>, Jan 19, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5be8f130f0122716ee092a39828bfffc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083302,"asset_id":111588361,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083302/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588361"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588361"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588361; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588361]").text(description); $(".js-view-count[data-work-id=111588361]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588361; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588361']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588361, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5be8f130f0122716ee092a39828bfffc" } } $('.js-work-strip[data-work-id=111588361]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588361,"title":"Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"Systems biology offers enormous potential to understand the complexity of human brain aging and neurodegenerative diseases. Proteomics has an important role in these investigations because of its unique strengths and because of the potential central pathogenic contribution of pathological protein to several of these diseases. Here we have reviewed the methods and presented some examples of liquid chromatography-electrospray ionization-tandem mass spectrometry-based proteomics, with and without quantification using isotope-coded affinity tags, in the investigation of aging and Alzheimer's disease. As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases.","publication_date":{"day":19,"month":1,"year":2015,"errors":{}},"publication_name":"Journal of Separation Science","grobid_abstract_attachment_id":109083302},"translated_abstract":null,"internal_url":"https://www.academia.edu/111588361/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs","translated_internal_url":"","created_at":"2023-12-16T13:45:43.848-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":109083302,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083302/thumbnails/1.jpg","file_name":"j.nurx.2006.05.00220231216-1-7ufonk.pdf","download_url":"https://www.academia.edu/attachments/109083302/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Liquid_chromatography_with_tandem_mass_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083302/j.nurx.2006.05.00220231216-1-7ufonk-libre.pdf?1702763228=\u0026response-content-disposition=attachment%3B+filename%3DLiquid_chromatography_with_tandem_mass_s.pdf\u0026Expires=1732811388\u0026Signature=AwO25vm3mke6W2IQFyxe8-ENC-PHWQMhjqZRr01Dc6Goquj1nAzrFdWQv1ln6dAEZ9LvsG7d-rakkMBw5b0~-o~DcEtpLsYKSnwCpZABLX-fOyEkWF-QRe31bp6yNtUAgQdbgWnG5x-ZF2woFZ66xlCPjtLoOachyoyi5ZpyP6Qp9EtLnVxtwuKJpA2LTIekPX4-kpziurOpM18MbEvc-gDTt7cRIlGAe9-avVsonJRYV6qSzLSR6VqVb7~ot8lhldIRnrXiKrrfVX04wdAI-7590GlDSV0KlAs3owf3fLDHOm7DZJAfV2drewlcBmpBvCHNlQX5tHKZ6v2psAC5gw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[{"id":109083302,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083302/thumbnails/1.jpg","file_name":"j.nurx.2006.05.00220231216-1-7ufonk.pdf","download_url":"https://www.academia.edu/attachments/109083302/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Liquid_chromatography_with_tandem_mass_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083302/j.nurx.2006.05.00220231216-1-7ufonk-libre.pdf?1702763228=\u0026response-content-disposition=attachment%3B+filename%3DLiquid_chromatography_with_tandem_mass_s.pdf\u0026Expires=1732811388\u0026Signature=AwO25vm3mke6W2IQFyxe8-ENC-PHWQMhjqZRr01Dc6Goquj1nAzrFdWQv1ln6dAEZ9LvsG7d-rakkMBw5b0~-o~DcEtpLsYKSnwCpZABLX-fOyEkWF-QRe31bp6yNtUAgQdbgWnG5x-ZF2woFZ66xlCPjtLoOachyoyi5ZpyP6Qp9EtLnVxtwuKJpA2LTIekPX4-kpziurOpM18MbEvc-gDTt7cRIlGAe9-avVsonJRYV6qSzLSR6VqVb7~ot8lhldIRnrXiKrrfVX04wdAI-7590GlDSV0KlAs3owf3fLDHOm7DZJAfV2drewlcBmpBvCHNlQX5tHKZ6v2psAC5gw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry"},{"id":4527,"name":"Africa","url":"https://www.academia.edu/Documents/in/Africa"},{"id":4656,"name":"Chromatography","url":"https://www.academia.edu/Documents/in/Chromatography"},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":67215,"name":"Separation Science","url":"https://www.academia.edu/Documents/in/Separation_Science"},{"id":163275,"name":"Tandem Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Tandem_Mass_Spectrometry"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography"}],"urls":[{"id":37213574,"url":"https://doi.org/10.1002/jssc.201401301"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588306"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588306/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries"><img alt="Research paper thumbnail of Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries" class="work-thumbnail" src="https://attachments.academia-assets.com/109083249/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588306/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries">Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries</a></div><div class="wp-workCard_item"><span>BMJ Open</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. In this article we investigate complementary aspects of the amlodipine and captopril samples so to explain the previously observed low assays for these two drugs.DesignPost hoc analysis of the captopril and amlodipine drugs samples and their packages collected in the context of the SEVEN study.Setting10 countries were concerned: Benin, Burkina Faso, Congo, Democratic Republic of the Congo, Guinea, Côte d’Ivoire, Mauritania, Niger, Senegal and Togo.ParticipantsLocal scientists and hospital practitioners collected the drug samples in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7702779c6d346de844994193cb571f07" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083249,"asset_id":111588306,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083249/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588306; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588306]").text(description); $(".js-view-count[data-work-id=111588306]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588306; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588306']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588306, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7702779c6d346de844994193cb571f07" } } $('.js-work-strip[data-work-id=111588306]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588306,"title":"Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries","translated_title":"","metadata":{"abstract":"ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. In this article we investigate complementary aspects of the amlodipine and captopril samples so to explain the previously observed low assays for these two drugs.DesignPost hoc analysis of the captopril and amlodipine drugs samples and their packages collected in the context of the SEVEN study.Setting10 countries were concerned: Benin, Burkina Faso, Congo, Democratic Republic of the Congo, Guinea, Côte d’Ivoire, Mauritania, Niger, Senegal and Togo.ParticipantsLocal scientists and hospital practitioners collected the drug samples in...","publisher":"BMJ","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"BMJ Open"},"translated_abstract":"ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588218"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588218/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament"><img alt="Research paper thumbnail of Management des risques appliqué au développement pharmaceutique du médicament" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588218/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament">Management des risques appliqué au développement pharmaceutique du médicament</a></div><div class="wp-workCard_item"><span>Médicaments et produits pharmaceutiques</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cad...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d&#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588218"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588218"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588218; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588218]").text(description); $(".js-view-count[data-work-id=111588218]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588218; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588218']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588218, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588218]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588218,"title":"Management des risques appliqué au développement pharmaceutique du médicament","translated_title":"","metadata":{"abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.","publisher":"Editions Techniques de l Ingenieur","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Médicaments et produits pharmaceutiques"},"translated_abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.","internal_url":"https://www.academia.edu/111588218/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament","translated_internal_url":"","created_at":"2023-12-16T13:43:07.056-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Management_des_risques_appliqué_au_développement_pharmaceutique_du_médicament","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":951,"name":"Humanities","url":"https://www.academia.edu/Documents/in/Humanities"},{"id":4486,"name":"Political Science","url":"https://www.academia.edu/Documents/in/Political_Science"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588193"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588193/Etude_de_biocompatibilit%C3%A9_des_films_%C3%A0_base_de_COC_en_tant_que_mat%C3%A9riaux_implantables"><img alt="Research paper thumbnail of Etude de biocompatibilité des films à base de COC en tant que matériaux implantables" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588193/Etude_de_biocompatibilit%C3%A9_des_films_%C3%A0_base_de_COC_en_tant_que_mat%C3%A9riaux_implantables">Etude de biocompatibilité des films à base de COC en tant que matériaux implantables</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, af...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, afin d’evaluer leur potentiel de biomateriaux implantables.Cette evaluation est realisee par le suivi de plusieurs parametres : viabilite cellulaire/cytotoxicite, evaluation des phenomenes de stress oxydant, inflammatoires et hemocompatibilite. Une relation entre ces reponses biologiques et les proprietes physico chimiques des materiaux etudies a ete apprehendee.Les resultats montrent une bonne biocompatibilite des films testes avec un impact significatif de la presence des additifs (anti-oxydant et lubrifiant) sur les parametres biologiques et physico-chimiques evalues.L’effet simule du vieillissement biologique de ces materiaux sur leur biocompatibilite et leurs caracteres physico-chimiques a egalement ete etudie. Des conditions de pH et d’oxydation extremes, ainsi que le contact avec des macrophages pendant 1 mois, ont un effet sur la surface et sur l’interaction des films de COC avec l’environnement biologique sans compromettre leur biocompatbilite. La presence d’additifs a egalement eu un impact sur ces modifications.En suivant une logique de management du risque, la systematisation de l’ensemble des methodes developpees a permis d’obtenir une approche simplifiee et validee au sein du laboratoire, applicable a l’ensemble des materiaux naturels ou synthetiques susceptibles d’etre utilises dans la fabrication des DM implantables</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588193"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588193"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588193; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588193]").text(description); $(".js-view-count[data-work-id=111588193]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588193; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588193']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588193, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588193]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588193,"title":"Etude de biocompatibilité des films à base de COC en tant que matériaux implantables","translated_title":"","metadata":{"abstract":"L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, afin d’evaluer leur potentiel de biomateriaux implantables.Cette evaluation est realisee par le suivi de plusieurs parametres : viabilite cellulaire/cytotoxicite, evaluation des phenomenes de stress oxydant, inflammatoires et hemocompatibilite. Une relation entre ces reponses biologiques et les proprietes physico chimiques des materiaux etudies a ete apprehendee.Les resultats montrent une bonne biocompatibilite des films testes avec un impact significatif de la presence des additifs (anti-oxydant et lubrifiant) sur les parametres biologiques et physico-chimiques evalues.L’effet simule du vieillissement biologique de ces materiaux sur leur biocompatibilite et leurs caracteres physico-chimiques a egalement ete etudie. Des conditions de pH et d’oxydation extremes, ainsi que le contact avec des macrophages pendant 1 mois, ont un effet sur la surface et sur l’interaction des films de COC avec l’environnement biologique sans compromettre leur biocompatbilite. La presence d’additifs a egalement eu un impact sur ces modifications.En suivant une logique de management du risque, la systematisation de l’ensemble des methodes developpees a permis d’obtenir une approche simplifiee et validee au sein du laboratoire, applicable a l’ensemble des materiaux naturels ou synthetiques susceptibles d’etre utilises dans la fabrication des DM implantables","publication_date":{"day":27,"month":11,"year":2018,"errors":{}}},"translated_abstract":"L’objet de ce travail est l’etude de la biocompatibilite in vitro des materiaux a base de COC, afin d’evaluer leur potentiel de biomateriaux implantables.Cette evaluation est realisee par le suivi de plusieurs parametres : viabilite cellulaire/cytotoxicite, evaluation des phenomenes de stress oxydant, inflammatoires et hemocompatibilite. Une relation entre ces reponses biologiques et les proprietes physico chimiques des materiaux etudies a ete apprehendee.Les resultats montrent une bonne biocompatibilite des films testes avec un impact significatif de la presence des additifs (anti-oxydant et lubrifiant) sur les parametres biologiques et physico-chimiques evalues.L’effet simule du vieillissement biologique de ces materiaux sur leur biocompatibilite et leurs caracteres physico-chimiques a egalement ete etudie. Des conditions de pH et d’oxydation extremes, ainsi que le contact avec des macrophages pendant 1 mois, ont un effet sur la surface et sur l’interaction des films de COC avec l’environnement biologique sans compromettre leur biocompatbilite. La presence d’additifs a egalement eu un impact sur ces modifications.En suivant une logique de management du risque, la systematisation de l’ensemble des methodes developpees a permis d’obtenir une approche simplifiee et validee au sein du laboratoire, applicable a l’ensemble des materiaux naturels ou synthetiques susceptibles d’etre utilises dans la fabrication des DM implantables","internal_url":"https://www.academia.edu/111588193/Etude_de_biocompatibilit%C3%A9_des_films_%C3%A0_base_de_COC_en_tant_que_mat%C3%A9riaux_implantables","translated_internal_url":"","created_at":"2023-12-16T13:42:35.710-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Etude_de_biocompatibilité_des_films_à_base_de_COC_en_tant_que_matériaux_implantables","translated_slug":"","page_count":null,"language":"fr","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"}],"urls":[{"id":37213433,"url":"http://www.theses.fr/s142458"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588192/LES_ALIMENTS_TRADITIONNELS_REM%C3%88DES_DE_BONNE_FEMME_OU_PHARMACOP%C3%89E_DU_e_SI%C3%88CLE"><img alt="Research paper thumbnail of LES ALIMENTS TRADITIONNELS : REMÈDES DE BONNE FEMME OU PHARMACOPÉE DU e SIÈCLE" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588192/LES_ALIMENTS_TRADITIONNELS_REM%C3%88DES_DE_BONNE_FEMME_OU_PHARMACOP%C3%89E_DU_e_SI%C3%88CLE">LES ALIMENTS TRADITIONNELS : REMÈDES DE BONNE FEMME OU PHARMACOPÉE DU e SIÈCLE</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hund...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hundreds of years as a spice and in traditional medicine. Indeed, this molecule possesses anti-inflammatory and anti-cancer properties after oral or topical administration. In addition to its antioxidant power, curcumin also acts on several cell signalling pathways, various enzymes, the immune system, the atherosclerosis process, angiogenesis and cell adhesion. Its effects on gene transcription or on the induction of apoptosis seem to be particularly promising for use in cancer chemoprevention and chemotherapy in patients. Phase I clinical trials did not show any toxic effect of curcumin, even at high dosages, but phase II clinical studies will be needed to confirm these positive preclinical results. Phytochemicals derived from dietary components or plants traditionally used to combat human diseases remain topical as potential medicines, with scientific and molecular confirmation of their biological activities. Consequently, the regulations governing the use of molecules such as curcumin need to be clarified.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588192]").text(description); $(".js-view-count[data-work-id=111588192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588192, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588192,"title":"LES ALIMENTS TRADITIONNELS : REMÈDES DE BONNE FEMME OU PHARMACOPÉE DU e SIÈCLE","translated_title":"","metadata":{"abstract":"ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hundreds of years as a spice and in traditional medicine. Indeed, this molecule possesses anti-inflammatory and anti-cancer properties after oral or topical administration. In addition to its antioxidant power, curcumin also acts on several cell signalling pathways, various enzymes, the immune system, the atherosclerosis process, angiogenesis and cell adhesion. Its effects on gene transcription or on the induction of apoptosis seem to be particularly promising for use in cancer chemoprevention and chemotherapy in patients. Phase I clinical trials did not show any toxic effect of curcumin, even at high dosages, but phase II clinical studies will be needed to confirm these positive preclinical results. Phytochemicals derived from dietary components or plants traditionally used to combat human diseases remain topical as potential medicines, with scientific and molecular confirmation of their biological activities. Consequently, the regulations governing the use of molecules such as curcumin need to be clarified.","publication_date":{"day":16,"month":2,"year":2008,"errors":{}}},"translated_abstract":"ABSTRACT Curcumin is a polyphenol derived from a plant named turmeric, and has been used for hundreds of years as a spice and in traditional medicine. Indeed, this molecule possesses anti-inflammatory and anti-cancer properties after oral or topical administration. In addition to its antioxidant power, curcumin also acts on several cell signalling pathways, various enzymes, the immune system, the atherosclerosis process, angiogenesis and cell adhesion. Its effects on gene transcription or on the induction of apoptosis seem to be particularly promising for use in cancer chemoprevention and chemotherapy in patients. Phase I clinical trials did not show any toxic effect of curcumin, even at high dosages, but phase II clinical studies will be needed to confirm these positive preclinical results. Phytochemicals derived from dietary components or plants traditionally used to combat human diseases remain topical as potential medicines, with scientific and molecular confirmation of their biological activities. Consequently, the regulations governing the use of molecules such as curcumin need to be clarified.","internal_url":"https://www.academia.edu/111588192/LES_ALIMENTS_TRADITIONNELS_REM%C3%88DES_DE_BONNE_FEMME_OU_PHARMACOP%C3%89E_DU_e_SI%C3%88CLE","translated_internal_url":"","created_at":"2023-12-16T13:42:35.579-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"LES_ALIMENTS_TRADITIONNELS_REMÈDES_DE_BONNE_FEMME_OU_PHARMACOPÉE_DU_e_SIÈCLE","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":951,"name":"Humanities","url":"https://www.academia.edu/Documents/in/Humanities"}],"urls":[{"id":37213432,"url":"https://www.em-consulte.com/en/article/79129"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588191"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588191/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs"><img alt="Research paper thumbnail of Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs" class="work-thumbnail" src="https://attachments.academia-assets.com/109083185/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588191/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs">Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs</a></div><div class="wp-workCard_item"><span>Journal of Separation Science</span><span>, Jan 19, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7ad9ab0ac15839f857ef5bf013f4d1bd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083185,"asset_id":111588191,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083185/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588191; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588191]").text(description); $(".js-view-count[data-work-id=111588191]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588191; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588191']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588191, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7ad9ab0ac15839f857ef5bf013f4d1bd" } } $('.js-work-strip[data-work-id=111588191]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588191,"title":"Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs","translated_title":"","metadata":{"publisher":"Wiley-Blackwell","grobid_abstract":"Systems biology offers enormous potential to understand the complexity of human brain aging and neurodegenerative diseases. Proteomics has an important role in these investigations because of its unique strengths and because of the potential central pathogenic contribution of pathological protein to several of these diseases. Here we have reviewed the methods and presented some examples of liquid chromatography-electrospray ionization-tandem mass spectrometry-based proteomics, with and without quantification using isotope-coded affinity tags, in the investigation of aging and Alzheimer's disease. As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases.","publication_date":{"day":19,"month":1,"year":2015,"errors":{}},"publication_name":"Journal of Separation Science","grobid_abstract_attachment_id":109083185},"translated_abstract":null,"internal_url":"https://www.academia.edu/111588191/Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs","translated_internal_url":"","created_at":"2023-12-16T13:42:35.446-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":109083185,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083185/thumbnails/1.jpg","file_name":"j.nurx.2006.05.00220231216-1-za3m4y.pdf","download_url":"https://www.academia.edu/attachments/109083185/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Liquid_chromatography_with_tandem_mass_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083185/j.nurx.2006.05.00220231216-1-za3m4y-libre.pdf?1702763237=\u0026response-content-disposition=attachment%3B+filename%3DLiquid_chromatography_with_tandem_mass_s.pdf\u0026Expires=1732811388\u0026Signature=eyCq9SQbra4yzHO5OgzvM6PgwGBrRlu428uAnxVHPWr1N2wuWLzTgyrJdD9UG-yfjLCMLFvvaZ0MUu0HF5HSdE8fCJXfuYGq3gUZi7cde2wPyiMV928euMyc3zQ2AfFznO5O~AoVdDUDOA2605prwXYQhBu-MUFew9Wvuflz1L4Thl623N0-QAJkrJLSEL9POcYwLQfWfu4NgH77k6oOS8evQ3EouHneFlG-1XtRmyJUJsp45X7oSh2cdPkFQQUpwai6o6Mtinic45oWR8AlrwtXJww1jrV9Fg-pxwLyBCdEsoPb7HPYHCvjW6xhM4Q9U7It5rrG592fd7cE6xJpCg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Liquid_chromatography_with_tandem_mass_spectrometry_for_the_simultaneous_identification_and_quantification_of_cardiovascular_drugs_applied_to_the_detection_of_substandard_and_falsified_drugs","translated_slug":"","page_count":8,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[{"id":109083185,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109083185/thumbnails/1.jpg","file_name":"j.nurx.2006.05.00220231216-1-za3m4y.pdf","download_url":"https://www.academia.edu/attachments/109083185/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Liquid_chromatography_with_tandem_mass_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109083185/j.nurx.2006.05.00220231216-1-za3m4y-libre.pdf?1702763237=\u0026response-content-disposition=attachment%3B+filename%3DLiquid_chromatography_with_tandem_mass_s.pdf\u0026Expires=1732811388\u0026Signature=eyCq9SQbra4yzHO5OgzvM6PgwGBrRlu428uAnxVHPWr1N2wuWLzTgyrJdD9UG-yfjLCMLFvvaZ0MUu0HF5HSdE8fCJXfuYGq3gUZi7cde2wPyiMV928euMyc3zQ2AfFznO5O~AoVdDUDOA2605prwXYQhBu-MUFew9Wvuflz1L4Thl623N0-QAJkrJLSEL9POcYwLQfWfu4NgH77k6oOS8evQ3EouHneFlG-1XtRmyJUJsp45X7oSh2cdPkFQQUpwai6o6Mtinic45oWR8AlrwtXJww1jrV9Fg-pxwLyBCdEsoPb7HPYHCvjW6xhM4Q9U7It5rrG592fd7cE6xJpCg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry"},{"id":4527,"name":"Africa","url":"https://www.academia.edu/Documents/in/Africa"},{"id":4656,"name":"Chromatography","url":"https://www.academia.edu/Documents/in/Chromatography"},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":67215,"name":"Separation Science","url":"https://www.academia.edu/Documents/in/Separation_Science"},{"id":163275,"name":"Tandem Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Tandem_Mass_Spectrometry"},{"id":246560,"name":"High Pressure Liquid Chromatography","url":"https://www.academia.edu/Documents/in/High_Pressure_Liquid_Chromatography"}],"urls":[{"id":37213431,"url":"https://doi.org/10.1002/jssc.201401301"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588190/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries"><img alt="Research paper thumbnail of Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries" class="work-thumbnail" src="https://attachments.academia-assets.com/109083184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588190/Post_hoc_study_to_investigate_the_potential_causes_of_poor_quality_of_cardiovascular_medicines_collected_in_sub_Saharan_countries">Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries</a></div><div class="wp-workCard_item"><span>BMJ Open</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. In this article we investigate complementary aspects of the amlodipine and captopril samples so to explain the previously observed low assays for these two drugs.DesignPost hoc analysis of the captopril and amlodipine drugs samples and their packages collected in the context of the SEVEN study.Setting10 countries were concerned: Benin, Burkina Faso, Congo, Democratic Republic of the Congo, Guinea, Côte d’Ivoire, Mauritania, Niger, Senegal and Togo.ParticipantsLocal scientists and hospital practitioners collected the drug samples in...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5bf1ce5c07c44fbc8fa1a55f070d8cb1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083184,"asset_id":111588190,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083184/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588190]").text(description); $(".js-view-count[data-work-id=111588190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588190, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5bf1ce5c07c44fbc8fa1a55f070d8cb1" } } $('.js-work-strip[data-work-id=111588190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588190,"title":"Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries","translated_title":"","metadata":{"abstract":"ObjectivesThe incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588189/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament"><img alt="Research paper thumbnail of Management des risques appliqué au développement pharmaceutique du médicament" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588189/Management_des_risques_appliqu%C3%A9_au_d%C3%A9veloppement_pharmaceutique_du_m%C3%A9dicament">Management des risques appliqué au développement pharmaceutique du médicament</a></div><div class="wp-workCard_item"><span>Médicaments et produits pharmaceutiques</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cad...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d&#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588189; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588189]").text(description); $(".js-view-count[data-work-id=111588189]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588189; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588189']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588189, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111588189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588189,"title":"Management des risques appliqué au développement pharmaceutique du médicament","translated_title":"","metadata":{"abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. Cette derniere consiste a identifier les situations a risque pour chaque attribut ou parametre du procede et a les analyser par rapport a leur probabilite de survenue, leurs consequences et leur detectabilite. Les niveaux de risque correspondant peuvent ainsi etre definis, permettant d’ajuster les conditions et les moyens de maitrise complementaires.","publisher":"Editions Techniques de l Ingenieur","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Médicaments et produits pharmaceutiques"},"translated_abstract":"Cet article presente un exemple de gestion des risques lies aux procedes mis en œuvre dans le cadre du developpement pharmaceutique d\u0026#39;une forme orale solide, avec integration de la demarche de gestion des risques lies au procede. 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C, Materials for biological applications</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6d037a3993b39bd4b25d5f33b0ccab97" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083182,"asset_id":111588188,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083182/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588188]").text(description); $(".js-view-count[data-work-id=111588188]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588188']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588188, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6d037a3993b39bd4b25d5f33b0ccab97" } } $('.js-work-strip[data-work-id=111588188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588188,"title":"Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing","translated_title":"","metadata":{"abstract":"Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. 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For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588185"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588185/Characterization_of_the_surface_physico_chemistry_of_plasticized_PVC_used_in_blood_bag_and_infusion_tubing"><img alt="Research paper thumbnail of Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing" class="work-thumbnail" src="https://attachments.academia-assets.com/109083177/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588185/Characterization_of_the_surface_physico_chemistry_of_plasticized_PVC_used_in_blood_bag_and_infusion_tubing">Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing</a></div><div class="wp-workCard_item"><span>Materials science & engineering. C, Materials for biological applications</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="afc1281cd06bc8963db4029ce2c9fe06" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109083177,"asset_id":111588185,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109083177/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588185"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588185; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111588185]").text(description); $(".js-view-count[data-work-id=111588185]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111588185; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111588185']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111588185, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "afc1281cd06bc8963db4029ce2c9fe06" } } $('.js-work-strip[data-work-id=111588185]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111588185,"title":"Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing","translated_title":"","metadata":{"abstract":"Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"Materials science \u0026 engineering. C, Materials for biological applications"},"translated_abstract":"Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111588158"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111588158/Phototransformation_patterns_of_the_antiplatelet_drug_tirofiban_in_aqueous_solution_relevant_to_drug_delivery_and_storage"><img alt="Research paper thumbnail of Phototransformation patterns of the antiplatelet drug tirofiban in aqueous solution, relevant to drug delivery and storage" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111588158/Phototransformation_patterns_of_the_antiplatelet_drug_tirofiban_in_aqueous_solution_relevant_to_drug_delivery_and_storage">Phototransformation patterns of the antiplatelet drug tirofiban in aqueous solution, relevant to drug delivery and storage</a></div><div class="wp-workCard_item"><span>New Journal of Chemistry</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions and the photoproducts formed are not structurally alerting for genotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111588158"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111588158"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111588158; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87212306"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87212306/PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study"><img alt="Research paper thumbnail of PH002: Cardiovascular drugs poor quality and mortality in 10sub-saharan countries: the SEVEN study" class="work-thumbnail" src="https://attachments.academia-assets.com/91486053/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87212306/PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study">PH002: Cardiovascular drugs poor quality and mortality in 10sub-saharan countries: the SEVEN study</a></div><div class="wp-workCard_item"><span>International Journal of Clinical Pharmacy</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eace35ab2e0ff77ce9816ffbacd27990" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91486053,"asset_id":87212306,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91486053/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87212306"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87212306"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87212306; 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Its subtype, group A (b-haemolytic) strep (GAS) causes common pharyngitis (also known as ''strep throat''). Novel rapid antigen detection tests allow for diagnosis of Group A Strep at the point-of-care and are ideally suited for use by community pharmacists. The objective of the study is to evaluate the impact and feasibility of community pharmacist-directed GAS testing. Setting and method: A retrospective analysis of aggregate billing data was conducted using descriptive statistics to evaluate the effectiveness of a community pharmacist-directed strep testing program at Shoppers Drug Mart pharmacies in the Canadian provinces of British Columbia, Alberta, and Nova Scotia. Pharmacists trained in sample collection offered the screening to patients with symptoms suggestive of Strep from November 28, 2015 to May 31, 2016. Throat swabs were collected and analysed using the BD Veritor TM system for rapid detection of GAS. Main outcome measures: Proportion of GAS-positive cases that resulted in the same day initiation of antibiotic therapy by pharmacists. Results: 7050 patients were tested across 204 participating locations. Average age was 27.3 years with children (5-14) representing 30.7% of the population. 25.5% of patients tested positive for GAS. Of the patients who screened positive, antibiotic therapy was initiated within the same day in 68.7% of cases. In Alberta, where pharmacists have advanced prescribing authority, same day initiation of therapy was 73.8% compared to a rate of 40.5% (p \\ 0.0001) in the other jurisdictions. Conclusion: These results highlight both the public readiness to access point of care services in community pharmacies and the ability of pharmacists to conveniently expedite management of patients with GAS. Community pharmacy-based Strep testing can facilitate prompt and appropriate access to antibiotic therapy as was demonstrated in those regions with advanced prescribing authority. Communication of recommendations to the physician in a timely manner remains a barrier to accessing treatment in those regions without this additional scope of practice. CP-PC002: Influence of physicians' beliefs about statins on patients' beliefs and adherence on statin therapy","publication_date":{"day":null,"month":null,"year":2017,"errors":{}},"publication_name":"International Journal of Clinical Pharmacy","grobid_abstract_attachment_id":91486053},"translated_abstract":null,"internal_url":"https://www.academia.edu/87212306/PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study","translated_internal_url":"","created_at":"2022-09-24T09:11:31.747-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":91486053,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91486053/thumbnails/1.jpg","file_name":"pmc7089505.pdf","download_url":"https://www.academia.edu/attachments/91486053/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"PH002_Cardiovascular_drugs_poor_quality.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91486053/pmc7089505-libre.pdf?1664036967=\u0026response-content-disposition=attachment%3B+filename%3DPH002_Cardiovascular_drugs_poor_quality.pdf\u0026Expires=1732811388\u0026Signature=G8H5iu~o-yMlEKTaKrsy815kqsGbWiVImao7GbKQKfO2eja9p96adAVvZTkey7PZtU2Mh--vdP46wVVWNpGnPqGb0BzSAxT5vanXj-WT4QLmDunKGnZ45NEyhkWkfdv1W8uUtAz0HpuNh78KaCOeUYwByu9WswANiX2bVibPqL5Jvg5-MKc174971H~wRBpSkdvDNMB0coMlpC1CT~fDMTUlmLqBFlN~sZKXhTZhxnkX0GXhFpjcDQH9F-GXUeUgND3kr2GQWu6SCewL9GdgTjnpi8FvDYr6r1h1R9WfNxM7GbdXBa5TMAOtSHn8LmLT-sPHIFI3G~isAX02R9KfqQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"PH002_Cardiovascular_drugs_poor_quality_and_mortality_in_10sub_saharan_countries_the_SEVEN_study","translated_slug":"","page_count":134,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[{"id":91486053,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91486053/thumbnails/1.jpg","file_name":"pmc7089505.pdf","download_url":"https://www.academia.edu/attachments/91486053/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"PH002_Cardiovascular_drugs_poor_quality.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91486053/pmc7089505-libre.pdf?1664036967=\u0026response-content-disposition=attachment%3B+filename%3DPH002_Cardiovascular_drugs_poor_quality.pdf\u0026Expires=1732811388\u0026Signature=G8H5iu~o-yMlEKTaKrsy815kqsGbWiVImao7GbKQKfO2eja9p96adAVvZTkey7PZtU2Mh--vdP46wVVWNpGnPqGb0BzSAxT5vanXj-WT4QLmDunKGnZ45NEyhkWkfdv1W8uUtAz0HpuNh78KaCOeUYwByu9WswANiX2bVibPqL5Jvg5-MKc174971H~wRBpSkdvDNMB0coMlpC1CT~fDMTUlmLqBFlN~sZKXhTZhxnkX0GXhFpjcDQH9F-GXUeUgND3kr2GQWu6SCewL9GdgTjnpi8FvDYr6r1h1R9WfNxM7GbdXBa5TMAOtSHn8LmLT-sPHIFI3G~isAX02R9KfqQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389132"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389132/Biocompatibility_of_polymer_based_biomaterials_and_medical_devices_regulations_in_vitro_screening_and_risk_management"><img alt="Research paper thumbnail of Biocompatibility of polymer-based biomaterials and medical devices - regulations, in vitro screening and risk-management" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389132/Biocompatibility_of_polymer_based_biomaterials_and_medical_devices_regulations_in_vitro_screening_and_risk_management">Biocompatibility of polymer-based biomaterials and medical devices - regulations, in vitro screening and risk-management</a></div><div class="wp-workCard_item"><span>Biomaterials science</span><span>, Jan 24, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Biomaterials play an increasing role in modern health care systems. Biocompatibility poses a sign...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Biomaterials play an increasing role in modern health care systems. Biocompatibility poses a significant challenge for manufacturers of medical devices and contemporary intelligent drug delivery technologies from materials development to market approval. Despite a highly regulated environment, biocompatibility evaluation of biomaterials for medical devices is a complex task related to various factors that include mainly chemical nature and physical properties of the material, the contact tissue and duration of contact. Although international standards, such as ISO 10993-1, are generally employed to prove regulatory compliance needed for market clearance or for initiating clinical investigations, they may not offer sufficient guidance, or risk-management perspective when it comes to choosing materials or appropriate in vitro biocompatibility screening methods when developing medical devices. The global normative approach towards the biocompatibility evaluation of medical devices is p...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389132"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389132"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389132; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389132]").text(description); $(".js-view-count[data-work-id=74389132]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389132; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389132']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389132, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389132]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389132,"title":"Biocompatibility of polymer-based biomaterials and medical devices - regulations, in vitro screening and risk-management","translated_title":"","metadata":{"abstract":"Biomaterials play an increasing role in modern health care systems. 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Although international standards, such as ISO 10993-1, are generally employed to prove regulatory compliance needed for market clearance or for initiating clinical investigations, they may not offer sufficient guidance, or risk-management perspective when it comes to choosing materials or appropriate in vitro biocompatibility screening methods when developing medical devices. 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Part A</span><span>, Jan 5, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility. The cytotoxicity was evaluated according to ISO 10993-5 guidelines using L929 fibroblasts, HUVEC and THP-1-derived macrophages. Oxidative stress (ROS, GSH/GSSG and SOD analysis) and pro-inflammatory cytokines (Il-6 and TNF-α secretion) were quantified using THP-1 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion and activation (membranous P-selectin expression). Results show that the different types of COC have successfully passed the in vitro biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably li...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389131"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389131"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389131; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389131]").text(description); $(".js-view-count[data-work-id=74389131]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389131; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389131']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389131, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389131]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389131,"title":"Biocompatibility assessment of cyclic olefin copolymers: Impact of two additives on cytotoxicity, oxidative stress, inflammatory reactions and hemocompatibility","translated_title":"","metadata":{"abstract":"This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility. The cytotoxicity was evaluated according to ISO 10993-5 guidelines using L929 fibroblasts, HUVEC and THP-1-derived macrophages. Oxidative stress (ROS, GSH/GSSG and SOD analysis) and pro-inflammatory cytokines (Il-6 and TNF-α secretion) were quantified using THP-1 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion and activation (membranous P-selectin expression). Results show that the different types of COC have successfully passed the in vitro biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably li...","publication_date":{"day":5,"month":1,"year":2017,"errors":{}},"publication_name":"Journal of biomedical materials research. Part A"},"translated_abstract":"This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility. The cytotoxicity was evaluated according to ISO 10993-5 guidelines using L929 fibroblasts, HUVEC and THP-1-derived macrophages. Oxidative stress (ROS, GSH/GSSG and SOD analysis) and pro-inflammatory cytokines (Il-6 and TNF-α secretion) were quantified using THP-1 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion and activation (membranous P-selectin expression). Results show that the different types of COC have successfully passed the in vitro biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably li...","internal_url":"https://www.academia.edu/74389131/Biocompatibility_assessment_of_cyclic_olefin_copolymers_Impact_of_two_additives_on_cytotoxicity_oxidative_stress_inflammatory_reactions_and_hemocompatibility","translated_internal_url":"","created_at":"2022-03-23T08:11:15.216-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Biocompatibility_assessment_of_cyclic_olefin_copolymers_Impact_of_two_additives_on_cytotoxicity_oxidative_stress_inflammatory_reactions_and_hemocompatibility","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":57799,"name":"Biocompatibility","url":"https://www.academia.edu/Documents/in/Biocompatibility"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":189424,"name":"Blood Coagulation","url":"https://www.academia.edu/Documents/in/Blood_Coagulation"},{"id":209508,"name":"Platelet activation mechanism","url":"https://www.academia.edu/Documents/in/Platelet_activation_mechanism"},{"id":246971,"name":"Olefin Polymerization","url":"https://www.academia.edu/Documents/in/Olefin_Polymerization"},{"id":892969,"name":"Materials Testing","url":"https://www.academia.edu/Documents/in/Materials_Testing"},{"id":1031067,"name":"Biocompatible Materials","url":"https://www.academia.edu/Documents/in/Biocompatible_Materials"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1900203,"name":"Hemolysis","url":"https://www.academia.edu/Documents/in/Hemolysis"},{"id":3802434,"name":"Human Umbilical Vein Endothelial Cells","url":"https://www.academia.edu/Documents/in/Human_Umbilical_Vein_Endothelial_Cells"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389130"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389130/Fighting_fake_medicines_First_quality_evaluation_of_cardiac_drugs_in_Africa"><img alt="Research paper thumbnail of Fighting fake medicines: First quality evaluation of cardiac drugs in Africa" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389130/Fighting_fake_medicines_First_quality_evaluation_of_cardiac_drugs_in_Africa">Fighting fake medicines: First quality evaluation of cardiac drugs in Africa</a></div><div class="wp-workCard_item"><span>International journal of cardiology</span><span>, Jan 19, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The growing menace of poor quality and falsified drugs constitutes a major hazard, compromising h...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The growing menace of poor quality and falsified drugs constitutes a major hazard, compromising healthcare and patient outcomes. Efforts to assess drug standards worldwide have almost exclusively focused on anti-microbial drugs; with no study to date on cardiovascular drugs. Our study aims to assess quality of seven routinely used cardiovascular medications (anticoagulants, antihypertensives and statins) in ten Sub-Saharan African countries. Drugs were prospectively collected using standardized methods between 2012 and 2014 from licensed (random pharmacies) and unlicensed (street-markets) places of sale in Africa. We developed a validated reversed-phase liquid chromatography with tandem mass spectrometry method to accurately quantify the active ingredient in a certified public laboratory. 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Chem.</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions an...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions and the photoproducts formed are not structurally alerting for genotoxicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389129"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389129"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389129; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389129]").text(description); $(".js-view-count[data-work-id=74389129]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389129; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389129']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389129, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389129]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389129,"title":"Phototransformation-Pattern of Antiplatelet Drug Tirofiban in Aqueous Solution, Relevant To Drug Delivery and Storage","translated_title":"","metadata":{"abstract":"Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions and the photoproducts formed are not structurally alerting for genotoxicity.","publisher":"Royal Society of Chemistry (RSC)","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"New J. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389128"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389128/PCN92_Value_of_Alopecia_for_Lung_Cancer_Patient_Treated_by_Second_Line_Chemotherapy_A_Willingness_to_Pay_Study"><img alt="Research paper thumbnail of PCN92 Value of Alopecia for Lung Cancer Patient Treated by Second Line Chemotherapy: A Willingness to Pay Study" class="work-thumbnail" src="https://attachments.academia-assets.com/82559203/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389128/PCN92_Value_of_Alopecia_for_Lung_Cancer_Patient_Treated_by_Second_Line_Chemotherapy_A_Willingness_to_Pay_Study">PCN92 Value of Alopecia for Lung Cancer Patient Treated by Second Line Chemotherapy: A Willingness to Pay Study</a></div><div class="wp-workCard_item"><span>Value in Health</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ed52ca97c04eab98f253a07cebd50b32" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82559203,"asset_id":74389128,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82559203/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389128"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389128"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389128; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389126"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389126/PSY37_Assessment_of_the_Global_Cost_of_Transfusion_in_French_Orthopedic_Surgery_Wards"><img alt="Research paper thumbnail of PSY37 Assessment of the Global Cost of Transfusion in French Orthopedic Surgery Wards" class="work-thumbnail" src="https://attachments.academia-assets.com/82559205/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389126/PSY37_Assessment_of_the_Global_Cost_of_Transfusion_in_French_Orthopedic_Surgery_Wards">PSY37 Assessment of the Global Cost of Transfusion in French Orthopedic Surgery Wards</a></div><div class="wp-workCard_item"><span>Value in Health</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3438c590ca22f084c890e58c9f8409c3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82559205,"asset_id":74389126,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82559205/download_file?st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&st=MTczMjgwNzc4OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389126"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389126"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389126; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389125"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389125/Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France"><img alt="Research paper thumbnail of Pharmaceutical Costs of Desensitization Therapy in Patients Awaiting Lung Transplantation in France" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389125/Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France">Pharmaceutical Costs of Desensitization Therapy in Patients Awaiting Lung Transplantation in France</a></div><div class="wp-workCard_item"><span>BioDrugs</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leuko...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leukocyte antigen (HLA) antibodies in patients awaiting lung transplant have recently been developed. The off-label use of high-dose intravenous polyvalent immunoglobulins (IVIg) and/or plasmapheresis changes the economical weight of pharmaceutical cost before lung transplantation. Our objective was to assess the budgetary impact of pharmaceutical costs of desensitization therapy. Two observational studies were conducted in 2009 and 2010 at the Bichat Claude Bernard (BCB) hospital in France. The first assessed the real pharmaceutical costs, and identified cost drivers, of desensitized (D+) patients awaiting lung transplantation. The second compared pharmaceutical and clinical data between D+ and non-treated (D-) patients. The major cost drivers were IVIg, representing 89.7 % of pharmaceutical costs. The real cost of drugs was €4,392 ± 647 per hospitalization. Mean hospitalization and annual pharmaceutical costs per patient were significantly higher for D+ than for D- patients (€6,972 vs. 2,925 and €13,074 vs. 399). D+ patients had a significantly higher average number of annual hospitalizations than did D- patients. Total IVIg costs represented 98 % of the pharmaceutical costs for desensitization stays. Pharmaceutical costs represented 40 % of total hospitalization costs for D+ versus only 7 % for D-. New desensitization protocols can help to manage the immunological hurdle of anti-donor antibodies in lung transplantation. They are expensive and not yet correctly covered by national health insurance, as they are supported by hospital budgets. A medico-economical evaluation of IVIg use in this indication seems necessary.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389125"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389125"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389125; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389125]").text(description); $(".js-view-count[data-work-id=74389125]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389125; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389125']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389125, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389125]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389125,"title":"Pharmaceutical Costs of Desensitization Therapy in Patients Awaiting Lung Transplantation in France","translated_title":"","metadata":{"abstract":"Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leukocyte antigen (HLA) antibodies in patients awaiting lung transplant have recently been developed. The off-label use of high-dose intravenous polyvalent immunoglobulins (IVIg) and/or plasmapheresis changes the economical weight of pharmaceutical cost before lung transplantation. Our objective was to assess the budgetary impact of pharmaceutical costs of desensitization therapy. Two observational studies were conducted in 2009 and 2010 at the Bichat Claude Bernard (BCB) hospital in France. The first assessed the real pharmaceutical costs, and identified cost drivers, of desensitized (D+) patients awaiting lung transplantation. The second compared pharmaceutical and clinical data between D+ and non-treated (D-) patients. The major cost drivers were IVIg, representing 89.7 % of pharmaceutical costs. The real cost of drugs was €4,392 ± 647 per hospitalization. Mean hospitalization and annual pharmaceutical costs per patient were significantly higher for D+ than for D- patients (€6,972 vs. 2,925 and €13,074 vs. 399). D+ patients had a significantly higher average number of annual hospitalizations than did D- patients. Total IVIg costs represented 98 % of the pharmaceutical costs for desensitization stays. Pharmaceutical costs represented 40 % of total hospitalization costs for D+ versus only 7 % for D-. New desensitization protocols can help to manage the immunological hurdle of anti-donor antibodies in lung transplantation. They are expensive and not yet correctly covered by national health insurance, as they are supported by hospital budgets. A medico-economical evaluation of IVIg use in this indication seems necessary.","publisher":"Springer Science and Business Media LLC","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"BioDrugs"},"translated_abstract":"Based on solid experience in renal transplant, new treatments aiming to decrease anti-human leukocyte antigen (HLA) antibodies in patients awaiting lung transplant have recently been developed. The off-label use of high-dose intravenous polyvalent immunoglobulins (IVIg) and/or plasmapheresis changes the economical weight of pharmaceutical cost before lung transplantation. Our objective was to assess the budgetary impact of pharmaceutical costs of desensitization therapy. Two observational studies were conducted in 2009 and 2010 at the Bichat Claude Bernard (BCB) hospital in France. The first assessed the real pharmaceutical costs, and identified cost drivers, of desensitized (D+) patients awaiting lung transplantation. The second compared pharmaceutical and clinical data between D+ and non-treated (D-) patients. The major cost drivers were IVIg, representing 89.7 % of pharmaceutical costs. The real cost of drugs was €4,392 ± 647 per hospitalization. Mean hospitalization and annual pharmaceutical costs per patient were significantly higher for D+ than for D- patients (€6,972 vs. 2,925 and €13,074 vs. 399). D+ patients had a significantly higher average number of annual hospitalizations than did D- patients. Total IVIg costs represented 98 % of the pharmaceutical costs for desensitization stays. Pharmaceutical costs represented 40 % of total hospitalization costs for D+ versus only 7 % for D-. New desensitization protocols can help to manage the immunological hurdle of anti-donor antibodies in lung transplantation. They are expensive and not yet correctly covered by national health insurance, as they are supported by hospital budgets. A medico-economical evaluation of IVIg use in this indication seems necessary.","internal_url":"https://www.academia.edu/74389125/Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France","translated_internal_url":"","created_at":"2022-03-23T08:11:14.669-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Pharmaceutical_Costs_of_Desensitization_Therapy_in_Patients_Awaiting_Lung_Transplantation_in_France","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":22213,"name":"Pharmacoeconomics","url":"https://www.academia.edu/Documents/in/Pharmacoeconomics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France"},{"id":51530,"name":"Transplantation","url":"https://www.academia.edu/Documents/in/Transplantation"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization"},{"id":1221634,"name":"Introvenous Immunoglobulins","url":"https://www.academia.edu/Documents/in/Introvenous_Immunoglobulins"},{"id":2474611,"name":"Costs and Cost Analysis","url":"https://www.academia.edu/Documents/in/Costs_and_Cost_Analysis"},{"id":2731176,"name":"Lung Transplantation","url":"https://www.academia.edu/Documents/in/Lung_Transplantation"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74389082"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74389082/Identification_of_the_major_degradation_pathways_of_ticagrelor"><img alt="Research paper thumbnail of Identification of the major degradation pathways of ticagrelor" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74389082/Identification_of_the_major_degradation_pathways_of_ticagrelor">Identification of the major degradation pathways of ticagrelor</a></div><div class="wp-workCard_item"><span>Journal of Pharmaceutical and Biomedical Analysis</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker u...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker used as antiplatelet drug. Forced degradation under various stress conditions was carried out. The degradation products have been detected and identified by high-pressure liquid chromatography multistage mass spectrometry (LC-MS(n)) along with high-resolution mass spectrometry. C18 XTerra MS column combined with a linear gradient mobile phase composed of a mixture of 10 mM acetate ammonium/acetonitrile was shown suitable for drug and impurity determinations and validated as a stability indicating method. Structural elucidation of the degradation products relied on MS(n) studies and accurate mass measurements giving access to elemental compositions. Up to nine degradation products resulting from oxidation/auto-oxidation, S-dealkylation and N-dealkylation have been identified, covering a range of possible degradation pathways for derivatives with such functional groups. Kinetics was also studied in order to assess the molecule&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s shelf-life and to identify the most important degradation factors.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74389082"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74389082"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74389082; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=74389082]").text(description); $(".js-view-count[data-work-id=74389082]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 74389082; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='74389082']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 74389082, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=74389082]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":74389082,"title":"Identification of the major degradation pathways of ticagrelor","translated_title":"","metadata":{"abstract":"Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker used as antiplatelet drug. Forced degradation under various stress conditions was carried out. The degradation products have been detected and identified by high-pressure liquid chromatography multistage mass spectrometry (LC-MS(n)) along with high-resolution mass spectrometry. C18 XTerra MS column combined with a linear gradient mobile phase composed of a mixture of 10 mM acetate ammonium/acetonitrile was shown suitable for drug and impurity determinations and validated as a stability indicating method. Structural elucidation of the degradation products relied on MS(n) studies and accurate mass measurements giving access to elemental compositions. Up to nine degradation products resulting from oxidation/auto-oxidation, S-dealkylation and N-dealkylation have been identified, covering a range of possible degradation pathways for derivatives with such functional groups. Kinetics was also studied in order to assess the molecule\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s shelf-life and to identify the most important degradation factors.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Journal of Pharmaceutical and Biomedical Analysis"},"translated_abstract":"Ticagrelor is a direct-acting and reversible P2Y12-adenosine diphosphate (ADP) receptor blocker used as antiplatelet drug. Forced degradation under various stress conditions was carried out. The degradation products have been detected and identified by high-pressure liquid chromatography multistage mass spectrometry (LC-MS(n)) along with high-resolution mass spectrometry. C18 XTerra MS column combined with a linear gradient mobile phase composed of a mixture of 10 mM acetate ammonium/acetonitrile was shown suitable for drug and impurity determinations and validated as a stability indicating method. Structural elucidation of the degradation products relied on MS(n) studies and accurate mass measurements giving access to elemental compositions. Up to nine degradation products resulting from oxidation/auto-oxidation, S-dealkylation and N-dealkylation have been identified, covering a range of possible degradation pathways for derivatives with such functional groups. Kinetics was also studied in order to assess the molecule\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s shelf-life and to identify the most important degradation factors.","internal_url":"https://www.academia.edu/74389082/Identification_of_the_major_degradation_pathways_of_ticagrelor","translated_internal_url":"","created_at":"2022-03-23T08:10:35.951-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":9485082,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Identification_of_the_major_degradation_pathways_of_ticagrelor","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":9485082,"first_name":"Mélisande","middle_initials":"","last_name":"Bernard","page_name":"MélisandeBernard","domain_name":"wellsante","created_at":"2014-02-25T05:20:44.539-08:00","display_name":"Mélisande Bernard","url":"https://wellsante.academia.edu/M%C3%A9lisandeBernard"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":524,"name":"Analytical Chemistry","url":"https://www.academia.edu/Documents/in/Analytical_Chemistry"},{"id":4656,"name":"Chromatography","url":"https://www.academia.edu/Documents/in/Chromatography"},{"id":5769,"name":"Mass Spectrometry","url":"https://www.academia.edu/Documents/in/Mass_Spectrometry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":61232,"name":"Adenosine","url":"https://www.academia.edu/Documents/in/Adenosine"},{"id":549280,"name":"Reproducibility of Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results"},{"id":623612,"name":"Photolysis","url":"https://www.academia.edu/Documents/in/Photolysis"},{"id":1030794,"name":"Hydrolysis","url":"https://www.academia.edu/Documents/in/Hydrolysis"},{"id":1135814,"name":"Drug Stability","url":"https://www.academia.edu/Documents/in/Drug_Stability"},{"id":1256747,"name":"Oxidation-Reduction","url":"https://www.academia.edu/Documents/in/Oxidation-Reduction"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure"},{"id":3696980,"name":"Platelet Aggregation Inhibitors","url":"https://www.academia.edu/Documents/in/Platelet_Aggregation_Inhibitors"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"},{"id":3988601,"name":"limit of detection","url":"https://www.academia.edu/Documents/in/limit_of_detection"}],"urls":[]}, dispatcherData: dispatcherData }); 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