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oligomerization</title> <meta name="description" content="Search results for: oligomerization"> <meta name="keywords" content="oligomerization"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="oligomerization"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 11</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: oligomerization</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Optimization of the Conditions of Oligomerization and Polymerization Processes of Selected Olefins with the Use of Complex Compounds of Transition Metal Ions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Joanna%20Drze%C5%BCd%C5%BCon">Joanna Drzeżdżon</a>, <a href="https://publications.waset.org/abstracts/search?q=Marzena%20Bia%C5%82ek"> Marzena Białek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polyolefins are a group of materials used today in all areas of life. They are used in the food, domestic and other industries. In particular, polyethylene and polypropylene have found application in the production of packaging materials, pipes, containers, car parts as well as elements of medical equipment, e.g. syringes. Optimization of the polymerization and oligomerization processes of selected olefins is a very important stage before the technological implementation of polyolefin production. The purpose of the studies is to determine the conditions for ethylene polymerization as well as 3-buten-2-ol and 2-chloro-2-propen-1-ol oligomerization with the use of oxovanadium(IV) dipicolinate complexes with N-heterocyclic ligands. Additionally, the studies aims to determine the catalytic activities of the dipicolinate oxovanadium(IV) complexes with N-heterocyclic ligands in the studied polymerization and oligomerization processes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=buten-2-ol" title="buten-2-ol">buten-2-ol</a>, <a href="https://publications.waset.org/abstracts/search?q=dipicolinate" title=" dipicolinate"> dipicolinate</a>, <a href="https://publications.waset.org/abstracts/search?q=ethylene" title=" ethylene"> ethylene</a>, <a href="https://publications.waset.org/abstracts/search?q=polymerization" title=" polymerization"> polymerization</a>, <a href="https://publications.waset.org/abstracts/search?q=oligomerization" title=" oligomerization"> oligomerization</a>, <a href="https://publications.waset.org/abstracts/search?q=vanadium" title=" vanadium"> vanadium</a> </p> <a href="https://publications.waset.org/abstracts/142290/optimization-of-the-conditions-of-oligomerization-and-polymerization-processes-of-selected-olefins-with-the-use-of-complex-compounds-of-transition-metal-ions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142290.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">196</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Dipicolinate Complex of Oxovanadium(Iv) with 4,4′-Dimethoxy-2,2′-Bipyridyl as a New Generation Ziegler-Natta Precatalyst</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Joanna%20Drze%C5%BCd%C5%BCon">Joanna Drzeżdżon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polyvinyl alcohol and its derivatives such as 2-chloro-2-propen-1-ol have found application in many industries. They are mainly used for the production of adhesives, thickeners and stabilizers of emulsion paints, and surgical threads. Moreover, polyvinyl alcohol derivatives are indispensable reagents in the synthesis of hemiacetals. Polyolefins derived from polyvinyl alcohol are obtained by using catalysts belonging to complex compounds of transition metal ions. The aim of the studies is to the synthesis of a new complex, i.e. dipicolinate oxovanadium(IV) complex with 4,4’-dimethoxy-2,2’-bipyridyl, and to determine its catalytic activities. Moreover, the another aim of the studies was to set conditions for 2-chloro-2-propen-1-ol oligomerization. The catalytic system has been based on the dipicolinate complex of oxovanadium(IV) with 4,4’-dimethoxy-2,2’-bipyridyl and MMAO-12. The results of the studies showed that how a new oxovanadium(IV) complex compound effects on the 2-chloro-2-propen-1-ol oligomerization. Moreover, the results revealed that new catalytic material is a highly active catalyst for the investigated oligomerization. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=2-chloro-2-propen-1-ol" title="2-chloro-2-propen-1-ol">2-chloro-2-propen-1-ol</a>, <a href="https://publications.waset.org/abstracts/search?q=oligomerization" title=" oligomerization"> oligomerization</a>, <a href="https://publications.waset.org/abstracts/search?q=dipicolinate" title=" dipicolinate"> dipicolinate</a>, <a href="https://publications.waset.org/abstracts/search?q=vanadium" title=" vanadium"> vanadium</a>, <a href="https://publications.waset.org/abstracts/search?q=methylaluminoxane" title=" methylaluminoxane"> methylaluminoxane</a> </p> <a href="https://publications.waset.org/abstracts/147352/dipicolinate-complex-of-oxovanadiumiv-with-44-dimethoxy-22-bipyridyl-as-a-new-generation-ziegler-natta-precatalyst" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/147352.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">134</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Modeling of Oligomerization of Ethylene in a Falling film Reactor for the Production of Linear Alpha Olefins</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Adil%20A.%20Mohammed">Adil A. Mohammed</a>, <a href="https://publications.waset.org/abstracts/search?q=Seif-Eddeen%20K.%20Fateen"> Seif-Eddeen K. Fateen</a>, <a href="https://publications.waset.org/abstracts/search?q=Tamer%20S.%20Ahmed"> Tamer S. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Tarek%20M.%20Moustafa"> Tarek M. Moustafa </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Falling film were widely used for gas-liquid absorption and reaction process. Modeling of falling film for oligomerization of ethylene reaction to linear alpha olefins is developed. Although there are many researchers discuss modeling of falling film in many processes, there has been no publish study the simulation of falling film for the oligomerization of ethylene reaction to produce linear alpha olefins. The Comsol multiphysics software was used to simulate the mass transfer with chemical reaction in falling film absorption process. The effect of concentration profile absorption of the products through falling thickness is discussed. The effect of catalyst concentration, catalyst/co-catalyst ratio, and temperature is also studied. For the effect of the temperature, as it increase the concentration of C4 increase. For catalyst concentration and catalyst/co-catalyst ratio as they increases the concentration of C4 increases, till it reached almost constant value. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=falling%20film" title="falling film">falling film</a>, <a href="https://publications.waset.org/abstracts/search?q=oligomerization" title=" oligomerization"> oligomerization</a>, <a href="https://publications.waset.org/abstracts/search?q=comsol%20mutiphysics" title=" comsol mutiphysics"> comsol mutiphysics</a>, <a href="https://publications.waset.org/abstracts/search?q=linear%20alpha%20olefins" title=" linear alpha olefins"> linear alpha olefins</a> </p> <a href="https://publications.waset.org/abstracts/23890/modeling-of-oligomerization-of-ethylene-in-a-falling-film-reactor-for-the-production-of-linear-alpha-olefins" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23890.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">469</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Biophysical Characterization of the Inhibition of cGAS-DNA Sensing by KicGAS, Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20Bhowmik">D. Bhowmik</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Tian"> Y. Tian</a>, <a href="https://publications.waset.org/abstracts/search?q=Q.%20Yin"> Q. Yin</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Zhu"> F. Zhu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cyclic GMP-AMP synthase (cGAS), recognises cytoplasmic double-stranded DNA (dsDNA), indicative of bacterial and viral infections, as well as the leakage of self DNA by cellular dysfunction and stresses, to elicit the host's immune responses. Viruses also have developed numerous strategies to antagonize the cGAS-STING pathway. Kaposi's sarcoma-associated herpesvirus (KSHV) is a human DNA tumor virus that is the causative agent of Kaposi’s sarcoma and several other malignancies. To persist in the host, consequently causing diseases, KSHV must overcome the host innate immune responses, including the cGAS-STING DNA sensing pathway. We already found that ORF52 or KicGAS (KSHV inhibitor of cGAS), an abundant and basic gamma herpesvirus-conserved tegument protein, directly inhibits cGAS enzymatic activity. To better understand the mechanism, we have performed the biochemical and structural characterization of full-length KicGAS and various mutants in regarding binding to DNA. We observed that KicGAS is capable of self-association and identified the critical residues involved in the oligomerization process. We also characterized the DNA-binding of KicGAS and found that KicGAS cooperatively oligomerizes along the length of the double stranded DNA, the highly conserved basic residues at the c-terminal disordered region are crucial for DNA recognition. Deficiency in oligomerization also affects DNA binding. Thus DNA binding by KicGAS sequesters DNA and prevents it from being detected by cGAS, consequently inhibiting cGAS activation. KicGAS homologues also inhibit cGAS efficiently, suggesting inhibition of cGAS is evolutionarily conserved mechanism among gamma herpesvirus. These results highlight the important viral strategy to evade this innate immune sensor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kaposi%27s%20sarcoma-associated%20herpesvirus" title="Kaposi's sarcoma-associated herpesvirus">Kaposi's sarcoma-associated herpesvirus</a>, <a href="https://publications.waset.org/abstracts/search?q=KSHV" title=" KSHV"> KSHV</a>, <a href="https://publications.waset.org/abstracts/search?q=cGAS" title=" cGAS"> cGAS</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20binding" title=" DNA binding"> DNA binding</a>, <a href="https://publications.waset.org/abstracts/search?q=inhibition" title=" inhibition"> inhibition</a> </p> <a href="https://publications.waset.org/abstracts/116871/biophysical-characterization-of-the-inhibition-of-cgas-dna-sensing-by-kicgas-kaposis-sarcoma-associated-herpesvirus-inhibitor-of-cgas" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/116871.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Revealing the Structural and Dynamic Properties of Betaine Aldehyde Dehydrogenase 2 from Rice (Oryza sativa): Simulation Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Apisaraporn%20Baicharoen">Apisaraporn Baicharoen</a>, <a href="https://publications.waset.org/abstracts/search?q=Prapasiri%20Pongprayoon"> Prapasiri Pongprayoon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Betaine aldehyde dehydrogenase 2 (BADH2) is an enzyme that inhibits the accumulation of 2-acetyl-1-pyrroline (2AP), a potent flavor compound in rice fragrance. BADH2 contains three domains (NAD-binding, substrate-binding, and oligomerization domains). It catalyzes the oxidation of amino aldehydes. The lack of BADH2 results in the formation of 2AP and consequently an increase in rice fragrance. To date, inadequate data on BADH2 structure and function are available. An insight into the nature of BADH2 can serve as one of key starting points for the production of high quality fragrant rice. In this study, we therefore constructed the homology model of BADH2 and employed 500-ns Molecular Dynamics simulations (MD) to primarily understand the structural and dynamic properties of BADH2. Initially, Ramachandran plot confirms the good quality of modeled protein structure. Principle Component Analysis (PCA) was also calculated to capture the protein dynamics. Among 3 domains, the results show that NAD binding site is found to be more flexible. Moreover, interactions from key amino acids (N162, E260, C294, and Y419) that are crucial for function are investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=betaine%20aldehyde%20dehydrogenase%202" title="betaine aldehyde dehydrogenase 2">betaine aldehyde dehydrogenase 2</a>, <a href="https://publications.waset.org/abstracts/search?q=fragrant%20rice" title=" fragrant rice"> fragrant rice</a>, <a href="https://publications.waset.org/abstracts/search?q=homology%20modeling" title=" homology modeling"> homology modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics%20simulations" title=" molecular dynamics simulations"> molecular dynamics simulations</a> </p> <a href="https://publications.waset.org/abstracts/54917/revealing-the-structural-and-dynamic-properties-of-betaine-aldehyde-dehydrogenase-2-from-rice-oryza-sativa-simulation-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54917.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">215</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> The Effect of SIRT1 on NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3) Inflammasome of Osteoarthritis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=So%20Youn%20Park">So Youn Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Yi%20Sle%20Lee"> Yi Sle Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Ki%20Whan%20Hong"> Ki Whan Hong</a>, <a href="https://publications.waset.org/abstracts/search?q=Chi%20Dae%20Kim"> Chi Dae Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The role of metabolism in the pathogenesis of osteoarthritis is an emerging field. Metabolic alterations may be a role in osteoarthritis (OA) pathogenesis, and these changes influence joint destruction via several cytokine. Especially, in OA patients, levels of IL-1β are elevated in the synovial fluid, synovial membrane, subchondral bone, and cartilage. The IL-1β is activated by NLRP3 inflammasomes, and NLRP3 inflammasomes are cytosolic complexes that drive the production of other inflammatory cytokines, including IL-1β. In this study, we examined that SIRT1 suppresses IL-1β through inhibiting NLRP3 inflammasomes and SIRT1 ameliorates osteoarthritis. OA fibroblasts were isolated from synovium of OA patients. IL-1β and NLRP3 were detected in synovium of OA patients by immunohistochemistry. Lipopolysaccharides (LPS) stimulated the expression of active IL-1β mRNA in OA fibroblasts and combination of LPS, and adenosine triphosphate increased more the expression of active IL-1β in OA fibroblasts. The level of IL-1β was measured by western blot and ELISA assay. NLRP3 inflammasomes complex were measured by western blot. SIRT1 did not inhibit expression of NLRP3 inflammasome. So caspase-1, apoptotic speck-like protein containing a caspase recruitment domain (ASC) and NLRP3 protein were expressed in OA fibroblasts. But SIRT1 suppressed activation of IL-1β by inhibiting activity of caspase-1 via NLRP3 inflammasome in OA fibroblasts under LPS plus ATP stimulation. These results suggest that SIRT1 is a modulator of NLRP3 inflammasomes in OA fibroblasts and ameliorate IL-1β, so expression of SIRT1 in OA fibroblast may be a potential strategy for OA inflammation treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=osteoarthritis" title="osteoarthritis">osteoarthritis</a>, <a href="https://publications.waset.org/abstracts/search?q=inflammasome" title=" inflammasome"> inflammasome</a>, <a href="https://publications.waset.org/abstracts/search?q=SIRT1" title=" SIRT1"> SIRT1</a>, <a href="https://publications.waset.org/abstracts/search?q=IL-1beta" title=" IL-1beta"> IL-1beta</a> </p> <a href="https://publications.waset.org/abstracts/76630/the-effect-of-sirt1-on-nlrp3-nucleotide-oligomerization-domain-like-receptor-family-pyrin-domain-containing-3-inflammasome-of-osteoarthritis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76630.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">199</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Folding Pathway and Thermodynamic Stability of Monomeric GroEL</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sarita%20Puri">Sarita Puri</a>, <a href="https://publications.waset.org/abstracts/search?q=Tapan%20K.%20Chaudhuri"> Tapan K. Chaudhuri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Chaperonin GroEL is a tetradecameric Escherichia coli protein having identical subunits of 57 kDa. The elucidation of thermodynamic parameters related to stability for the native GroEL is not feasible as it undergoes irreversible unfolding because of its large size (800kDa) and multimeric nature. Nevertheless, it is important to determine the thermodynamic stability parameters for the highly stable GroEL protein as it helps in folding and holding of many substrate proteins during many cellular stresses. Properly folded monomers work as building-block for the formation of native tetradecameric GroEL. Spontaneous refolding behavior of monomeric GroEL makes it suitable for protein-denaturant interactions and thermodynamic stability based studies. The urea mediated unfolding is a three state process which means there is the formation of one intermediate state along with native and unfolded states. The heat mediated denaturation is a two-state process. The unfolding process is reversible as observed by the spontaneous refolding of denatured protein in both urea and head mediated refolding processes. Analysis of folding/unfolding data provides a measure of various thermodynamic stability parameters for the monomeric GroEL. The proposed mechanism of unfolding of monomeric GroEL is a three state process which involves formation of one stable intermediate having folded apical domain and unfolded equatorial, intermediate domains. Research in progress is to demonstrate the importance of specific residues in stability and oligomerization of GroEL protein. Several mutant versions of GroEL are under investigation to resolve the above mentioned issue. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=equilibrium%20unfolding" title="equilibrium unfolding">equilibrium unfolding</a>, <a href="https://publications.waset.org/abstracts/search?q=monomeric%20GroEl" title=" monomeric GroEl"> monomeric GroEl</a>, <a href="https://publications.waset.org/abstracts/search?q=spontaneous%20refolding" title=" spontaneous refolding"> spontaneous refolding</a>, <a href="https://publications.waset.org/abstracts/search?q=thermodynamic%20stability" title=" thermodynamic stability"> thermodynamic stability</a> </p> <a href="https://publications.waset.org/abstracts/67151/folding-pathway-and-thermodynamic-stability-of-monomeric-groel" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67151.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">282</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> New Platform of Biobased Aromatic Building Blocks for Polymers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sylvain%20Caillol">Sylvain Caillol</a>, <a href="https://publications.waset.org/abstracts/search?q=Maxence%20Fache"> Maxence Fache</a>, <a href="https://publications.waset.org/abstracts/search?q=Bernard%20Boutevin"> Bernard Boutevin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recent years have witnessed an increasing demand on renewable resource-derived polymers owing to increasing environmental concern and restricted availability of petrochemical resources. Thus, a great deal of attention was paid to renewable resources-derived polymers and to thermosetting materials especially, since they are crosslinked polymers and thus cannot be recycled. Also, most of thermosetting materials contain aromatic monomers, able to confer high mechanical and thermal properties to the network. Therefore, the access to biobased, non-harmful, and available aromatic monomers is one of the main challenges of the years to come. Starting from phenols available in large volumes from renewable resources, our team designed platforms of chemicals usable for the synthesis of various polymers. One of these phenols, vanillin, which is readily available from lignin, was more specifically studied. Various aromatic building blocks bearing polymerizable functions were synthesized: epoxy, amine, acid, carbonate, alcohol etc. These vanillin-based monomers can potentially lead to numerous polymers. The example of epoxy thermosets was taken, as there is also the problematic of bisphenol A substitution for these polymers. Materials were prepared from the biobased epoxy monomers obtained from vanillin. Their thermo-mechanical properties were investigated and the effect of the monomer structure was discussed. The properties of the materials prepared were found to be comparable to the current industrial reference, indicating a potential replacement of petrosourced, bisphenol A-based epoxy thermosets by biosourced, vanillin-based ones. The tunability of the final properties was achieved through the choice of monomer and through a well-controlled oligomerization reaction of these monomers. This follows the same strategy than the one currently used in industry, which supports the potential of these vanillin-derived epoxy thermosets as substitutes of their petro-based counterparts. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lignin" title="lignin">lignin</a>, <a href="https://publications.waset.org/abstracts/search?q=vanillin" title=" vanillin"> vanillin</a>, <a href="https://publications.waset.org/abstracts/search?q=epoxy" title=" epoxy"> epoxy</a>, <a href="https://publications.waset.org/abstracts/search?q=amine" title=" amine"> amine</a>, <a href="https://publications.waset.org/abstracts/search?q=carbonate" title=" carbonate"> carbonate</a> </p> <a href="https://publications.waset.org/abstracts/40489/new-platform-of-biobased-aromatic-building-blocks-for-polymers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40489.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">232</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Exploring the Role of Immune-Modulators in Pathogen Recognition Receptor NOD2 Mediated Protection against Visceral Leishmaniasis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Junaid%20Jibran%20Jawed">Junaid Jibran Jawed</a>, <a href="https://publications.waset.org/abstracts/search?q=Prasanta%20Saini"> Prasanta Saini</a>, <a href="https://publications.waset.org/abstracts/search?q=Subrata%20Majumdar"> Subrata Majumdar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Leishmania donovani infection causes severe host immune-suppression through the modulation of pathogen recognition receptors. Apart from TLRs (Toll Like Receptor), recent studies focus on the important contribution of NLR (NOD-Like Receptor) family member NOD1 and NOD2 as these receptors are capable of triggering host innate immunity. The aim of this study was to decipher the role of NOD1/NOD2 receptors during experimental visceral leishmaniasis (VL) and the important link between host failure and parasite evasion strategy. Method: The status of NOD1 and NOD2 receptors were analysed in uninfected and infected cells through western blotting and RT-PCR. The active contributions of these receptors in reducing parasite burden were confirmed by siRNA mediated silencing, and over-expression studies and the parasite numbers were calculated through microscopic examination of the Giemsa-stained slides. In-vivo studies were done by using non-toxic dose of Mw (Mycobacterium indicus pranii), Ara-LAM(Arabinoasylated lipoarabinomannan) along with MDP (Muramyl dipeptide) administration. Result: Leishmania donovani infection of the macrophages reduced the expression of NOD2 receptors whereas NOD1 remain unaffected. MDP, a NOD2-ligand, treatment during over-expression of NOD2, reduced the parasite burden effectively which was associated with increased pro-inflammatory cytokine generation and NO production. In experimental mouse model, Ara-LAM treatment increased the expression of NOD2 and in combination with MDP it showed active therapeutic potential against VL and found to be more effective than Mw which was already reported to be involved in NOD2 modulation. Conclusion: This work explores the essential contribution of NOD2 during experimental VL and mechanistic understanding of Ara-LAM + MDP combination therapy to work against this disease and highlighted NOD2 as an essential therapeutic target. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ara-LAM%20%28Arabinoacylated%20Lipoarabinomannan%29" title="Ara-LAM (Arabinoacylated Lipoarabinomannan)">Ara-LAM (Arabinoacylated Lipoarabinomannan)</a>, <a href="https://publications.waset.org/abstracts/search?q=NOD2%20%28nucleotide%20binding%20oligomerization%20receptor%202%29" title=" NOD2 (nucleotide binding oligomerization receptor 2)"> NOD2 (nucleotide binding oligomerization receptor 2)</a>, <a href="https://publications.waset.org/abstracts/search?q=MDP%20%28muramyl%20di%20peptide%29" title=" MDP (muramyl di peptide)"> MDP (muramyl di peptide)</a>, <a href="https://publications.waset.org/abstracts/search?q=visceral%20Leishmaniasis" title=" visceral Leishmaniasis"> visceral Leishmaniasis</a> </p> <a href="https://publications.waset.org/abstracts/80536/exploring-the-role-of-immune-modulators-in-pathogen-recognition-receptor-nod2-mediated-protection-against-visceral-leishmaniasis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80536.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">175</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Optimization and Evaluation of Different Pathways to Produce Biofuel from Biomass</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xiang%20Zheng">Xiang Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhaoping%20Zhong"> Zhaoping Zhong</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, Aspen Plus was used to simulate the whole process of biomass conversion to liquid fuel in different ways, and the main results of material and energy flow were obtained. The process optimization and evaluation were carried out on the four routes of cellulosic biomass pyrolysis gasification low-carbon olefin synthesis olefin oligomerization, biomass water pyrolysis and polymerization to jet fuel, biomass fermentation to ethanol, and biomass pyrolysis to liquid fuel. The environmental impacts of three biomass species (poplar wood, corn stover, and rice husk) were compared by the gasification synthesis pathway. The global warming potential, acidification potential, and eutrophication potential of the three biomasses were the same as those of rice husk > poplar wood > corn stover. In terms of human health hazard potential and solid waste potential, the results were poplar > rice husk > corn stover. In the popular pathway, 100 kg of poplar biomass was input to obtain 11.9 kg of aviation coal fraction and 6.3 kg of gasoline fraction. The energy conversion rate of the system was 31.6% when the output product energy included only the aviation coal product. In the basic process of hydrothermal depolymerization process, 14.41 kg aviation kerosene was produced per 100 kg biomass. The energy conversion rate of the basic process was 33.09%, which can be increased to 38.47% after the optimal utilization of lignin gasification and steam reforming for hydrogen production. The total exergy efficiency of the system increased from 30.48% to 34.43% after optimization, and the exergy loss mainly came from the concentration of precursor dilute solution. Global warming potential in environmental impact is mostly affected by the production process. Poplar wood was used as raw material in the process of ethanol production from cellulosic biomass. The simulation results showed that 827.4 kg of pretreatment mixture, 450.6 kg of fermentation broth, and 24.8 kg of ethanol were produced per 100 kg of biomass. The power output of boiler combustion reached 94.1 MJ, the unit power consumption in the process was 174.9 MJ, and the energy conversion rate was 33.5%. The environmental impact was mainly concentrated in the production process and agricultural processes. On the basis of the original biomass pyrolysis to liquid fuel, the enzymatic hydrolysis lignin residue produced by cellulose fermentation to produce ethanol was used as the pyrolysis raw material, and the fermentation and pyrolysis processes were coupled. In the coupled process, 24.8 kg ethanol and 4.78 kg upgraded liquid fuel were produced per 100 kg biomass with an energy conversion rate of 35.13%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biomass%20conversion" title="biomass conversion">biomass conversion</a>, <a href="https://publications.waset.org/abstracts/search?q=biofuel" title=" biofuel"> biofuel</a>, <a href="https://publications.waset.org/abstracts/search?q=process%20optimization" title=" process optimization"> process optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=life%20cycle%20assessment" title=" life cycle assessment"> life cycle assessment</a> </p> <a href="https://publications.waset.org/abstracts/163377/optimization-and-evaluation-of-different-pathways-to-produce-biofuel-from-biomass" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163377.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">70</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> The Role of Piceatannol in Counteracting Glyceraldehyde-3-Phosphate Dehydrogenase Aggregation and Nuclear Translocation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Joanna%20Gerszon">Joanna Gerszon</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandra%20Rodacka"> Aleksandra Rodacka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the pathogenesis of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, protein and peptide aggregation processes play a vital role in contributing to the formation of intracellular and extracellular protein deposits. One of the major components of these deposits is the oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Therefore, the purpose of this research was to answer the question whether piceatannol, a stilbene derivative, counteracts and/or slows down oxidative stress-induced GAPDH aggregation. The study also aimed to determine if this natural occurring compound prevents unfavorable nuclear translocation of GAPDH in hippocampal cells. The isothermal titration calorimetry (ITC) analysis indicated that one molecule of GAPDH can bind up to 8 molecules of piceatannol (7.3 ± 0.9). As a consequence of piceatannol binding to the enzyme, the loss of activity was observed. Parallel with GAPDH inactivation the changes in zeta potential, and loss of free thiol groups were noted. Nevertheless, the ligand-protein binding does not influence the secondary structure of the GAPDH. Precise molecular docking analysis of the interactions inside the active center allowed to presume that these effects are due to piceatannol ability to assemble a covalent binding with nucleophilic cysteine residue (Cys149) which is directly involved in the catalytic reaction. Molecular docking also showed that simultaneously 11 molecules of ligand can be bound to dehydrogenase. Taking into consideration obtained data, the influence of piceatannol on level of GAPDH aggregation induced by excessive oxidative stress was examined. The applied methods (thioflavin-T binding-dependent fluorescence as well as microscopy methods - transmission electron microscopy, Congo Red staining) revealed that piceatannol significantly diminishes level of GAPDH aggregation. Finally, studies involving cellular model (Western blot analyses of nuclear and cytosolic fractions and confocal microscopy) indicated that piceatannol-GAPDH binding prevents GAPDH from nuclear translocation induced by excessive oxidative stress in hippocampal cells. In consequence, it counteracts cell apoptosis. These studies demonstrate that by binding with GAPDH, piceatannol blocks cysteine residue and counteracts its oxidative modifications, that induce oligomerization and GAPDH aggregation as well as it prevents hippocampal cells from apoptosis by retaining GAPDH in the cytoplasm. All these findings provide a new insight into the role of piceatannol interaction with GAPDH and present a potential therapeutic strategy for some neurological disorders related to GAPDH aggregation. This work was supported by the by National Science Centre, Poland (grant number 2017/25/N/NZ1/02849). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glyceraldehyde-3-phosphate%20dehydrogenase" title="glyceraldehyde-3-phosphate dehydrogenase">glyceraldehyde-3-phosphate dehydrogenase</a>, <a href="https://publications.waset.org/abstracts/search?q=neurodegenerative%20disease" title=" neurodegenerative disease"> neurodegenerative disease</a>, <a href="https://publications.waset.org/abstracts/search?q=neuroprotection" title=" neuroprotection"> neuroprotection</a>, <a href="https://publications.waset.org/abstracts/search?q=piceatannol" title=" piceatannol"> piceatannol</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%20aggregation" title=" protein aggregation"> protein aggregation</a> </p> <a href="https://publications.waset.org/abstracts/89543/the-role-of-piceatannol-in-counteracting-glyceraldehyde-3-phosphate-dehydrogenase-aggregation-and-nuclear-translocation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89543.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">167</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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