CINXE.COM
Just a moment...
<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '9133fb9f5ae0ce5a',cH: 'vJ40IW4I5fw6W5Hn7ZKgGicnMOR7Y0ByxP8NJ6ubZ7s-1739776491-1.2.1.1-vlqUYmLOSLQ2KD5k1xfgnZp5qSHOQtNIsBtf5ajPa5Mv7kVKsRX2ofVgfXFthtIz',cUPMDTk: "\/doi\/10.1021\/acs.orglett.4c01735?__cf_chl_tk=t2pR4wPfU0BNt7mYyw1gXs754KpLOHyssPHSzGA2UqI-1739776491-1.0.1.1-IslgPEYFMLTkjGip20Vn0a4ZbpFYhzxE2MKU69s.nZo",cFPWv: 'b',cITimeS: '1739776491',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/acs.orglett.4c01735?__cf_chl_f_tk=t2pR4wPfU0BNt7mYyw1gXs754KpLOHyssPHSzGA2UqI-1739776491-1.0.1.1-IslgPEYFMLTkjGip20Vn0a4ZbpFYhzxE2MKU69s.nZo",md: "7kY8BrDQuLgMsLah1CbVAtLjANOdbOGnllz1sJFNzxk-1739776491-1.2.1.1-pr8CIKqNy3E2lRpklYYS5G3oh.VLBEnbNuxnVoY8J6bO1OtTUwgIfjJraLt_BepI8vMYIf8ctvfJJAf.ddV.L5Tl_IZlLXDHJgrud7SlCxHTba15ZdXSCxRk0No9iSqtmtcBNUrsTQldvaBJECoHsLcEpZMZHnpTP_fwwIzwqqfqq82OKC.ggt4GYq6Iet5IguFbXNPStUv7ZnG6fHKu3asMloZ84_gRrS6Cm9U0IjD7mkSF.MpM_MTJDNIOdLZDuB6Pj5vvRH3J1dpBznNymVzL.ZFyIpWAHAIvmPw1Xg6emneMC_CYIqi1VrhJVj55sJ5THK0i4Dkqba_udk8f6mZUOP3g2p8zSC0PWtgFv1By9RWSWUzFIT_v.pis71f82H0xv89UKvAbajdCgDhuB0NNuGvQpy3qs1yZCqxsovIL9uZIu4rXYFrUGUjxXLTqF1wXLP75q8Qb82.fEKoQMfQRUMh0ogZ.lED51_2jaK76sfZ78yKghJMVDzN5g1YQmQMJBJargJ_aZfkuYaVsKcrc6DuRtZRmYHpk3TqaDQyaUl6ATItwpeKmwhk8ftf_QdSngG4Un7t_.70bgHCpU.oavF9OIBOJUGXaA918NhyYjgtpDTOgvtThNyo5ynF08csd37SmdENQhiANGoEDwqrfEBzm1gE60W6D2.DoIr9eCoIVZTdMFNPXVekQxWCq.y61pizmx2LjQkroa4fwrg22l_c4Z3LM9hyvWn5iYdyBcTRS_2enlSjHQz6bM395Lba6UguFQp5IlV8qKnh5YbzDuMyb1r3rkYavN.ErpRfP4FhpeHrZWCM2oHtqX7JIHpWWFhI.Wr8qCfpcfCa5JZlZG20Rkj8yGlquzLLhmDjSKFapSIV1NsBy8qwbBytxVJ3EH.TdsiH6m0lymYu5ISWUJWWJcAllQSd2piIE5iWoEtFoOg4xCTkFxjCreFHfDQovWmvkTayRmFxof_.cBKeDimu9Zep5KDidLYqgVZ1fUj2crGQ530DwZ34zoLFSAVbSLyk4Mo_64y01h.ImdLebkjTsPkYfK6HWoQw7WzQDEvpZhs.UQZvWUXwbgNBGouaZFhuBPI7fz4V2Gae9KSh5uonIyZXWeh8dIP2y84rALMnN4zyFhlyDSpIr7sFxONs5UURdn9iFLqIKi_qYX35Ouesve2KLVSITNPyVs3ZoGmu_.AGCmHEzzOtV6ULOLjbu2bWoGCD6spCQLZ67oDS1DAHRr9nln9nxSgU3OmJiTxARxoJJKacOnVt9gVH7eOTw.hLTSH5k2LRuUP7HxQZhJICE.EMCfRtknLm3KAhxBkclqJbQ5qWA.KUrwr.nlxl9R_xFGNiHpmBw13f6s6pOXOlLppz18UWRcsqjWXT0.3K7IVMV7tDWdjEOizwG7_F.YDrGaWxTfL2kNeNYNMZIDlyKBO7AAZvdslgvijEwEmmGqR4Di._RvGCDCQV0jg4sReHbOidaWL60iq_dAWokQBjV0hkdBBlHUFDsS6t4YT5IFd8VGRzJnjlqeUVcka9ZM7z3dqhdwsz7f5wwwbV39fOBYTapjip6EJS8Je2bm8qJ50lNMEpUmloRIkG0pz29cHxWPx3aMm4YT0qcF4SAlTaHupLi8hjwfl53qvmRbfOwFJ4bmnoDmyjix1GbKzhZ941RQQL5QjsMDruFHq4L6sREyPZ01vKVlTlOE.5K_EKE26vGNjl21riqNd50gTDkMnU66oDBH9C6x05dlDvuApBMra1H5z.Ar2cNDskk._o_6Vk9d16aaOnuezymbdi8MCmy6SakTGElGNj7eDH7miHLTUNc.XtCWvj7UleUx9dRUsEuTEQMjwPjsJMMRD_oXzWKofDszKv21MTcJAgIKpDhhAsBQYcO_glpFuRCWFmi6ulWUspBxHw6TTH7SDBkqqHRKmSgqnOFmYZkgOQ3xzOcbYBtKbvZny2Clpzxq.CxMRlDyUFZ9.8pmx67_Og4mVZWFAb9wGCfqx1bhXAXDUmXqvPAO.J1fDyC3xkrSQg_mdZAwAK__g4ETbbRjJAkP1zWXFLcnlsBRLIDBRuF.kD_tZmfleUbwkVVddLA9Tpuzl22FjrwFYHnVBfC5yH_EdnesCBmD6yEbiE3Ns9EYYIigPhd2F_qBmEUXXHbA3hOAbQIBO5GZMMgHP7Fv1FibWmHA6rXYp45DOSv826TkppBZ6qZr8bC9KVfDudZbxJb02_PXSR5khDDh5qLDlDCk0sU3Y41fykF803rKLS11954NxEMbCQHP1GjlePfdbvR7VasNgBULGmDa4nhXvX1kz3uJLXdFAtMScw4mzxWcn_duAJ.YhoEBUHEt9lA2YMKNSexR6GA6YKOGpRcKZaFKol_yKVKne2JBXTOYZLuBc029Gjpk75pYwYWNnULCyZlhg_67LyzgvF4FqhSbHd3oNPeHOiOPu.ZtvN3qHZV4mHdUVfMFCtkc1LLGouhSJgorr.rE4wr9LDXhwizOFw2iRzsoPDEyIwQpsNQWu9cCO._c4QfnBCtgHUi0ak5hb.vjz8iOOmwqnTVfXKI7eL0ARUvY5c.VV4zkjd7V3Rc.XnOwLcmm3vtS_qCm7g",mdrd: "1KmxKBpca9N3Q6HOtah43FRs1D8GD0WKDBLAF_JTt7o-1739776491-1.2.1.1-lxUSoqXkQdBs0iNPi4EWb98U.ui9pghIEtHdDunCe8mVzrT5EkjwyTVnMW1pZZp_xj9Uu7me.n9mSsoF2RI897L_ZMbNGAFm6AkhPMQyGxykcqL2SU_KQEWs_Zofa..NQSlpBfolUGgXY0bxtEEKPLc4S0GsM0hCvW12TlLpxJYhzz2fD1Oif9mQYhpIH86judgexzch4RZJ10sRfQhFXzR8XQmPCoenB1RJdyG88egXsQsLFafDWPNgQgaA1YVKQbbtGOuvfg7ypgUFsN8TjNPlMuE5ryiIeOYNlHjt34datPzTawAGABOrODSxTctszycHIRaQkBMSaR2iQbPmpymS4_eW3KqIeDoH05y5Z.vDzd.Z2HeOmC7Vkf0CIVa9npDJArV8FqzA9BeSOd1q2UpvVeBBIm0qR34PvhJ9mOo978REyBvdBX7nanE9ZEKsrBGS4o6kmelgJll7io_UtqiVAaj.QBunVz1Q5o.gWyQZh4PvExfO5HFuIDEB5K_l2fysS.NenkyJT8FrAtBG1bfxcWlURgic.48oMXFrfKfX_jpHrKasQhMBTNM9lV8hvy0O07bIzZtCJF5k1N9uY2cASl7AGs4hTz0c4r2KhMsVeIqdTBX_txD8ZeKa4j4AecjS7AYWsCZmlJ0D2wpMIF1XXs8Gg6PmjJneR7pgIaQfnF3lnas5C1vB44zNbEKTFmUnEn7C6ZE0n3z.aDIdAv5u8Utpw19d8i26NGPa3NDpx3nOTQx2gzOQovdc3LJl0_KFIqdr1VOKEtTOqxVUTeSm7MBMAss8jsBMUEnzd3paejsib7FHLBv_UB6UHO8h_Nfx8FYFKwt9P7RhSpP4q01BkRa70pHIVKs1.NMFCwN2v9IfVv79h.vv1qyHaAzIVNFxY9JLxQ29naDU0ZPaD1EYDQXpC2yUxq4Vmdx2AdQor.yywQbTq9p.YtBLALn4.KkQXVTd5jQ84dKCVb7QI0Q4E37ASe2.AzXnnVZ5Fi05pEl6q0Pu5njN44XbHWOki_xZ74KyOxguhil0B4WHxrXBr9vNyrsxtEfN.JfriXzCFAS.LsMoMB5UHWo_NX6xU7C.vkj4wvZvLQz4j.VDHSY1bVsDIIheu4B770QCTStQBVnJW2mfAlUYbcKU51PGawpeEYnYbplzlxLzQRlVBOhoTe3HLXZt4vwUWBCIBMel_feSGQE00y01Hr4konqk8YiZ7IY8jCmyMKzppznKS9.zBEcaLlEf779oUOd8cGFxzQl5mUILl3NLcHFduuX8Wuy8g3hy6JfdtDKOnKef6wJ2z6C_U5ADCmYMIOCh_4hbw4N66TsG3pYHm43GU4fpXfEaXXV0sO884VL_AEIq_pa9PRtb.9APWgf4_ut_W83qMJriv4sphH5sngztSCcRKp.DHEiBVo9IiXyXt8XWTo2zkVW5fHKivLhT8DCSvAj47LUrK.XQcLyV0O7iFrCZuz3p6CvLvBTb01ZwkmxUUBhrZpP_XQlINhASy_.pbvIDJ1Tuc0NNPyc8an88U.YbCY8hTs00yx4oHtEM5da20ms_edykQK5Bqiy_7UPZOEZhhg0ejDePJvHN4N4kIgnaxkOjzgQ4S6qgVrrOfPvtOi0cX0Rr4zfAJPf1ymH27wQFknpZAmpS5cm0oZ1KYgkszniL5PflLj5L2CED__za5Kwj7JvNLV99litxwJf.UgVVJIV1VnfIPURtOzxxTuvIGWS2XiRD_q007G5oA.lJxgcRZFGCECUR9P1Oq.lbIn0Q6e9ivSVv4o4TX5D4j4MTywF5qGYbEMme30AX7brz2OjbhZ4rUUeA9P2bL_ZWqWnF9w5yVu3DYkxZkesmlhqVpY8WYYitNPmocyMBRP.qkCDObIJeOL.UAmZYM7m3uBfZYuGwgwsvgjcs7ZXXuI3fVtJqxkzxOyDtQLnPXPjOIXb1Po_dSVUZzFbyXEMBAr8"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9133fb9f5ae0ce5a';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/acs.orglett.4c01735?__cf_chl_rt_tk=t2pR4wPfU0BNt7mYyw1gXs754KpLOHyssPHSzGA2UqI-1739776491-1.0.1.1-IslgPEYFMLTkjGip20Vn0a4ZbpFYhzxE2MKU69s.nZo" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>