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width="1.25rem" xmlns="http://www.w3.org/2000/svg"><polyline points="6 9 6 2 18 2 18 9"></polyline><path d="M6 18H4a2 2 0 0 1-2-2v-5a2 2 0 0 1 2-2h16a2 2 0 0 1 2 2v5a2 2 0 0 1-2 2h-2"></path><rect x="6" y="14" width="12" height="8"></rect></svg></a></button></div></div><div><div class="flex flex-wrap"><p class=" text-primary font-semibold">News</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1"></div><p class=" text-primary font-semibold">Article</p><div class="h-[16px] border-l-2 border-gray-400 mt-1 mx-1 "></div><time class="text-gray-500 " dateTime="2024-11-02T13:00:00.000">November 2, 2024</time></div><h1 class="text-[26px] font-medium leading-8">Health Equity & Access Weekly Roundup: November 2, 2024</h1><div class="py-3 text-gray-600 md:flex flex-col md:justify-between"><div class="flex flex-col xs:flex-row"><p class="mr-1 self-start">Author(s):</p><div class="flex flex-col xs:flex-row mb-3 md:mb-0"><div class="flex flex-wrap"><span class="text-md mr-2"><a class="text-author text-gray-500 hover:text-primary underline hover:no-underline decoration-gray-400" href="/authors/giuliana-grossi">Giuliana Grossi</a></span></div></div></div><div class="max-w-full"><div class="flex flex-wrap sm:flex-nowrap items-center w-fit my-2"></div><div class="w-full flex flex-col sm:flex-row justify-between mt-2"><div class="block md:hidden "><div class="mt-2 flex items-center max-w-fit"><button title="Health Equity & Access Weekly Roundup: November 2, 2024" aria-label="facebook" class="react-share__ShareButton" style="background-color:transparent;border:none;padding:0;font:inherit;color:inherit;cursor:pointer"><svg viewBox="0 0 64 64" width="32" height="32"><circle cx="32" cy="32" r="31" fill="#3b5998"></circle><path d="M34.1,47V33.3h4.6l0.7-5.3h-5.3v-3.4c0-1.5,0.4-2.6,2.6-2.6l2.8,0v-4.8c-0.5-0.1-2.2-0.2-4.1-0.2 c-4.1,0-6.9,2.5-6.9,7V28H24v5.3h4.6V47H34.1z" fill="white"></path></svg></button><button aria-label="twitter" class="react-share__ShareButton" 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2px; } audio { height: 40px; } .rhap_container { width: 300px !important; border-radius: 100px !important; height: 40px !important; box-shadow: 0px 0px 2px 2px rgba(0,0,0,0.1); } .rhap_progress-section { width: 150px; margin-left: 35px; } .rhap_controls-section { position: relative; bottom: .75rem; } .rhap_time { font-size: 12px; color: rgb(0,55,103); } .rhap_progress-bar { color: rgb(0,55,103) !important; } .rhap_progress-filled { background-color: rgb(0,55,103) !important; } .rhap_progress-indicator { height: 15px; width: 5px; top: -5px; margin-left: 1px; background-color: rgb(0,55,103) !important; } .rhap_repeat-button { display: none; } .rhap_volume-bar, rhap_volume-button, .rhap_volume-indicator { background: rgb(0,55,103) !important; } .rhap_volume-bar { height: 2px; width: 35px; position: relative; left: 22px; bottom: 21px; } .rhap_volume-button { // width: 5px; // height: 5px; flex: 0 0 26px; position: relative; left: 22px; bottom: 21px; } .rhap_volume-button svg { height: 18px; width: 18px; } .rhap_volume-indicator { height: 8px; width: 8px; top: -2.75px } .rhap_button-clear { color: rgb(0,55,103) !important; } .rhap_play-pause-button { color: rgb(0,55,103) !important; font-size: 30px !important; width: 30px !important; height: 30px !important; position: relative; right: 90px; bottom: 22px; } .rhap_main-controls button { color: rgb(0,55,103) !important; } audio::-webkit-media-controls-play-button, video::-webkit-media-controls-play-button { -webkit-appearance: media-play-button; color: #b8dcf6; } audio::-webkit-media-controls-panel { background-color: white !important; color: #000; } audio::-webkit-media-controls-current-time-display, audio::-webkit-media-controls-time-remaining-display { font-size: 12px; } </style></div></div></div><div class=" lg:w-full flex flex-col lg:flex-row lg:items-center lg:justify-end"></div><div class="w-full flex flex-col px-4 py-4 border-t border-b border-solid border-gray-400 my-4 "><h3 class="text-primary text-xl font-semibold">Key Takeaways</h3><ul class="list-disc px-8"><li class="py-2 "> Social determinants of health interventions face barriers, including unclear ROI, despite efforts to integrate health care and social services. </li><li class="py-2 "> Employers are shifting to equity-focused strategies to manage rising health care costs, with dissatisfaction in current pharmacy benefits management practices. </li><li class="py-2 hidden"> Medicare Advantage beneficiaries face plan disruptions, with income-based programs potentially mitigating increased out-of-pocket expenses. </li><li class="py-2 hidden"> Biosimilars offer significant cost savings and expanded access in oncology and immunology, promoting health equity. </li><li class="py-2 hidden"> AI tools show potential in identifying undiagnosed rare diseases, though further testing is needed for clinical application.</li></ul><span class="text-xs font-bold text-primary underline cursor-pointer mt-2 ml-4">SHOW MORE</span></div><p class="py-2 mb-2 text-sm italic text-gray-600">This week’s Center on Health Equity & Access highlights emphasize the role of social determinants of health in policy-making and underscore the importance of addressing rising costs and challenges employers face. </p><div class="py-2"><div class="blockText_blockContent__TbCXh"><h3 class="text-xl pb-4 pt-2"><a target="_blank" href="https://www.ajmc.com/view/understanding-the-financial-return-to-investments-in-the-social-determinants-of-health"><strong>Understanding the Financial Return to Investments in the Social Determinants of Health</strong></a></h3><p class="pb-2">Despite broad recognition of the important role social determinants of health (SDOH) play in health outcomes, substantial barriers remain, including the lack of clear evidence on such interventions' effectiveness and return on investment (ROI). Efforts by federal, state, and private sectors, like the Center for Medicare and Medicaid Innovation's Accountable Health Communities model, seek to bridge the gap between health care and social services. Yet, challenges persist in implementation and coordination with community-based organizations (CBOs). The authors outlined recommendations to enhance SDOH impact, such as increasing federal support, leveraging CBO expertise, expanding data-sharing, and fostering cross-sector partnerships, advocating for policy actions to promote sustainable SDOH funding.</p><p class="pb-2"></p><h3 class="text-xl pb-4 pt-2"><a target="_blank" href="https://www.ajmc.com/view/employers-shift-to-equity-focused-strategies-as-health-costs-outpace-wages"><strong>Employers Shift to Equity-Focused Strategies as Health Costs Outpace Wages</strong></a></h3><p class="pb-2">The Pulse of the Purchaser 2024 survey published this week by <a target="_blank" href="https://www.ajmc.com/partners/national-alliance">National Alliance of Healthcare Purchaser Coalitions</a> reveals that escalating health care costs are prompting employers to explore cost-management strategies that balance employee benefits with organizational sustainability. With 74% of employers concerned about the impact of rising health care costs on wages and benefits, many are considering shifts in cost sharing with employees and implementing targeted initiatives for high-cost claims, such as managed maternity benefits, early screening, and site-of-care redirection. Additionally, employers are prioritizing health equity, with 74% engaging in cross-departmental discussions on the topic and analyzing data to address disparities. The survey also highlights dissatisfaction with current pharmacy benefits manager practices, with over half of respondents considering a change to improve transparency and control.</p><p class="pb-2"></p><h3 class="text-xl pb-4 pt-2"><a target="_blank" href="https://www.ajmc.com/view/contributor-vulnerable-seniors-are-at-risk-with-looming-medicare-advantage-cuts-income-based-programs-can-minimize-the-damage"><strong>Contributor: Vulnerable Seniors Are at Risk With Looming Medicare Advantage Cuts—Income-Based Programs Can Minimize the Damage</strong></a></h3><p class="pb-2">The 2024 Medicare Advantage (MA) open enrollment period reveals significant challenges for beneficiaries as regulatory changes and financial pressures force MA plans to cut benefits and raise costs. With an average of 43 MA options, many seniors face plan disruptions, with 1.38 million losing access to their current plan and 4.56 million automatically moving to new plans. Key changes include increased Part D deductibles, reduced supplemental benefits like Flex Card allowances and over-the-counter coverage, and increased premiums, leaving many beneficiaries—particularly low-income seniors—at risk of higher out-of-pocket expenses. Income-based programs such as Medicaid could help alleviate these costs, but up to half of eligible seniors remain unenrolled. As seniors navigate these changes, using resources like the Medicare Advantage Annual Enrollment period checklist and external advisors may help them better understand their options and secure necessary benefits amidst the shifting landscape.</p><p class="pb-2"></p><h3 class="text-xl pb-4 pt-2"><a target="_blank" href="https://www.ajmc.com/view/new-ai-tool-identifies-undiagnosed-pnh-in-health-records"><strong>New AI Tool Identifies Undiagnosed PNH in Health Records</strong></a></h3><p class="pb-2">A recent study investigated using a machine learning model to help identify undiagnosed cases of paroxysmal nocturnal hemoglobinuria (PNH), a <a target="_blank" href="https://www.ajmc.com/compendium/rareblood">rare blood disorder</a> with high misdiagnosis rates due to its varied symptoms. The algorithm analyzed electronic health records data from the Optimum Patient Care Research Database, distinguishing PNH cases with significant specificity and accuracy by focusing on key clinical markers associated with PNH, such as aplastic anemia and hemolytic anemia. The initial Positive Predictive Value (PPV) was 60.4% (95% CI, 33% to 82%), indicating that over half of the flagged patients already had a PNH diagnosis in their records. However, when researchers adjusted for PNH’s rarity (3.81 cases per 100,000 individuals), the PPV decreased to 19.59% (95% CI, 7.63% to 41.81%), suggesting that approximately 1 in 5 flagged patients may need further investigation for PNH. The study’s findings underscore the potential of machine learning to improve early diagnosis of rare diseases, though additional testing on diverse datasets is required for clinical application.</p><p class="pb-2"></p><h3 class="text-xl pb-4 pt-2"><a target="_blank" href="https://www.ajmc.com/view/biosimilars-expand-access-and-reduce-costs-in-oncology-immunology"><strong>Biosimilars Expand Access and Reduce Costs in Oncology, Immunology</strong></a></h3><p class="pb-2">New research presented at the <a target="_blank" href="https://www.ajmc.com/conference/amcp-nexus">Academy of Managed Care Pharmacy (AMCP) Nexus</a> highlights the cost savings and access benefits of biosimilars in health care. With over 60 biosimilars approved in the US, these alternatives offer significant savings, especially in costly treatment areas like immunomodulation, oncology, and endocrinology. Studies showed biosimilars such as denosumab and adalimumab enable substantial budget-neutral savings, thereby expanding treatment access and promoting health equity. For example, a projected 70% adoption of biosimilar denosumab could save over $31 million in 5 years. Similarly, adalimumab biosimilars, with costs up to 80% lower than Humira (adalimumab), could extend access to treatments for chronic inflammatory conditions. This real-world evidence suggests biosimilars' growing role in reducing health care costs while broadening patient access to essential therapies.</p></div></div><div class="flex items-center lg:w-3/4 mb-4 pb-12"></div><div class="jsx-19ede9f0a5a45918 py-4 relative bg-primary md:px-8 -ml-6 xs:ml-0 w-screen xs:w-auto"><div class="jsx-19ede9f0a5a45918 px-4 sm:px-0"><div class="flex justify-between items-center py-1 space-x-4 border-0 select-none sm:border-b border-secondary"><div class="text-3xl text-white text-lg sm:text-3xl">Related Videos</div></div></div><div style="scroll-snap-type:none" class="jsx-19ede9f0a5a45918 flex items-start overflow-x-auto space-x-4 py-4 relative mx-auto w-full pl-4"><a id="" class="w-[200px] h-fit space-y-3 flex-none select-none no-underline" style="scroll-snap-align:center;text-decoration:none" href="/view/rems-program-supports-use-of-mavacamten-in-obstructive-hypertrophic-cardiomyopathy"><div class="w-full shadow-md shadow-gray-800 overflow-hidden relative 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mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/us-adhd-stimulant-shortage-highlights-growing-challenges-in-adult-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b6fb5039fb065b6265bd44eb4eb365c5b2c92738-3115x2076.jpg?fit=crop&auto=format" alt="medicine pills - Kwangmoozaa - stock.adobe.com.jpeg" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/us-adhd-stimulant-shortage-highlights-growing-challenges-in-adult-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent">US ADHD Stimulant Shortage Highlights Growing Challenges in Adult Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/us-adhd-stimulant-shortage-highlights-growing-challenges-in-adult-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">While name brands like Adderall and Vyvanse may have been recently removed from the FDA Drug Shortage Database, it's unclear if it'll last; meanwhile, many generic forms of attention-deficit/hyperactivity disorder (ADHD) medication are still in short supply.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-wellness-way?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a1728e6a06fccde8af20d2308f860344f9776b8f-800x400.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-wellness-way?utm_source=www.ajmc.com&utm_medium=relatedContent">Frameworks for Advancing Health Equity: Wellness Way</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-wellness-way?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The Wellness Way facility was designed to improve access to comprehensive outpatient care and address social determinants of health for a diverse patient population.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg?fit=crop&auto=format" alt="Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies?utm_source=www.ajmc.com&utm_medium=relatedContent">Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Accompanying these findings is a call for refined treatment strategies that have potential to better outcomes among patients who have unresectable stage III non–small cell lung cancer (NSCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">Breaking the Cycle: The Importance of Early Intervention in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Prompt care supports mental well-being, as hidradenitis suppurativa is often associated with depression and anxiety due to its physical and social challenges.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6bd0e6a5c734135abb6fa97501b6375dc31df9c2-5600x3733.jpg?fit=crop&auto=format" alt="Medicare enrollment model | image credit: Vitalii Vodolazskyi - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent">New Proposal Aims to Expand Medicaid and Medicare Coverage for Obesity Drugs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If made official, the proposed rule would give Part D and Medicaid beneficiaries expanded coverage to antiobesity drugs starting in 2026. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="relative hidden sm:block"><div class="mt-4 overflow-hidden"><div class="flex justify-between"><div class="flex items-center clear-both pt-4 pb-2 text-3xl lg:text-2xl xl:text-3xl min-w-fit ">Related Content </div><div class="hidden lg:flex w-full flex-col justify-end items-end"><div class="hidden w-full lg:flex flex-wrap pb-2 gap-x-2 gap-y-1 justify-end items-end"></div></div></div><div class="w-full mb-2 border border-secondary"></div><div class="lg:hidden flex flex-wrap items-center"></div><div class="flex flex-wrap w-full"><div class="jsx-ad50481d5ee26850 w-full h-full"><div><div><div class="text-[8px] text-center text-gray-500 hidden">Advertisement</div><div id="div-gpt-ad-infeed-1"></div></div></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/us-adhd-stimulant-shortage-highlights-growing-challenges-in-adult-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/b6fb5039fb065b6265bd44eb4eb365c5b2c92738-3115x2076.jpg?fit=crop&auto=format" alt="medicine pills - Kwangmoozaa - stock.adobe.com.jpeg" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/us-adhd-stimulant-shortage-highlights-growing-challenges-in-adult-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent">US ADHD Stimulant Shortage Highlights Growing Challenges in Adult Treatment</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/us-adhd-stimulant-shortage-highlights-growing-challenges-in-adult-treatment?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">While name brands like Adderall and Vyvanse may have been recently removed from the FDA Drug Shortage Database, it's unclear if it'll last; meanwhile, many generic forms of attention-deficit/hyperactivity disorder (ADHD) medication are still in short supply.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-wellness-way?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/a1728e6a06fccde8af20d2308f860344f9776b8f-800x400.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 21st 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-wellness-way?utm_source=www.ajmc.com&utm_medium=relatedContent">Frameworks for Advancing Health Equity: Wellness Way</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/frameworks-for-advancing-health-equity-wellness-way?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The Wellness Way facility was designed to improve access to comprehensive outpatient care and address social determinants of health for a diverse patient population.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex md:hidden justify-center items-center"></div><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738.jpg?fit=crop&auto=format" alt="Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 27th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies?utm_source=www.ajmc.com&utm_medium=relatedContent">Durvalumab Underutilization Highlights Gaps in NSCLC Treatment Strategies</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/maggie-l-shaw">Maggie L. Shaw</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/durvalumab-underutilization-highlights-gaps-in-nsclc-treatment-strategies?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Accompanying these findings is a call for refined treatment strategies that have potential to better outcomes among patients who have unresectable stage III non–small cell lung cancer (NSCLC).</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/4d74ae04b0508977864936ec08f2aaa199758e5c-1000x563.jpg?fit=crop&auto=format" alt="Managed Care Cast" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">October 29th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent">Breaking the Cycle: The Importance of Early Intervention in Hidradenitis Suppurativa</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/giuliana-grossi">Giuliana Grossi</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/breaking-the-cycle-the-importance-of-early-intervention-in-hidradenitis-suppurativa?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">Prompt care supports mental well-being, as hidradenitis suppurativa is often associated with depression and anxiety due to its physical and social challenges.</div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/6bd0e6a5c734135abb6fa97501b6375dc31df9c2-5600x3733.jpg?fit=crop&auto=format" alt="Medicare enrollment model | image credit: Vitalii Vodolazskyi - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent">New Proposal Aims to Expand Medicaid and Medicare Coverage for Obesity Drugs</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">If made official, the proposed rule would give Part D and Medicaid beneficiaries expanded coverage to antiobesity drugs starting in 2026. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div><div class="jsx-ad50481d5ee26850 w-full h-full"><div class="jsx-ad50481d5ee26850 flex flex-col sm:flex-row justify-between my-4 "><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><img src="https://cdn.sanity.io/images/0vv8moc6/ajmc/f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473.jpg?fit=crop&auto=format" alt="FDA Approval | image credit: gomixer - stock.adobe.com" width="288" class="jsx-ad50481d5ee26850 max-h-[200px] xs:w-[288px] "/></a><div class="jsx-ad50481d5ee26850 article-detail flex flex-col gap-[0.2rem] w-full sm:w-[46%] md:w-[65%]"><span class="jsx-ad50481d5ee26850 article-publish-date block italic text-sm text-gray-500 mt-[1rem] sm:mt-0">November 26th 2024</span><p class="jsx-ad50481d5ee26850 article-title font-bold text-[1rem]"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent">FDA Approves Imatinib Oral Solution for Treatment of Various Cancers</a></p><div class="jsx-ad50481d5ee26850 authors flex-row wrap gap-[0.2rem]"><a class="jsx-ad50481d5ee26850 text-[#00ADEF] underline text-sm italic" href="/authors/kyle-munz">Kyle Munz</a></div><div class="jsx-ad50481d5ee26850 article-summary"><a class="jsx-ad50481d5ee26850" href="/view/fda-approves-imatinib-oral-solution-for-treatment-of-various-cancers?utm_source=www.ajmc.com&utm_medium=relatedContent"><div class="jsx-ad50481d5ee26850 text-sm text-gray-500 py-1">The FDA approval marks the first oral solution indicated for patients with different forms of leukemia. </div></a></div></div></div><div style="border-bottom:1px solid #CCCCCC" class="jsx-ad50481d5ee26850"></div></div></div></div></div><div class="pb-24"></div></div><script type="application/ld+json">{"@context":"https://schema.org","@type":"NewsArticle","headline":"Health Equity & Access Weekly Roundup: November 2, 2024","datePublished":"2024-11-02T13:00:00.000Z","dateModified":"2024-11-01T19:12:32Z","inLanguage":"en-US","image":"https://cdn.sanity.io/images/0vv8moc6/ajmc/1fb0458d4007f177c86e1a37a8c9d4ba60b1f084-303x160.jpg?fit=crop&auto=format","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.ajmc.com/view/health-equity-access-weekly-roundup-november-2-2024"},"publisher":{"@type":"Organization","name":"AJMC","logo":{"@type":"ImageObject","url":"https://www.ajmc.com/ajmc_logo_inverted.png"}},"keywords":"Health Equity,Health Policy,Healthcare Coverage","articleBody":"Understanding the Financial Return to Investments in the Social Determinants of Health\n\nDespite broad recognition of the important role social determinants of health (SDOH) play in health outcomes, substantial barriers remain, including the lack of clear evidence on such interventions' effectiveness and return on investment (ROI). Efforts by federal, state, and private sectors, like the Center for Medicare and Medicaid Innovation's Accountable Health Communities model, seek to bridge the gap between health care and social services. Yet, challenges persist in implementation and coordination with community-based organizations (CBOs). The authors outlined recommendations to enhance SDOH impact, such as increasing federal support, leveraging CBO expertise, expanding data-sharing, and fostering cross-sector partnerships, advocating for policy actions to promote sustainable SDOH funding.\n\n\n\nEmployers Shift to Equity-Focused Strategies as Health Costs Outpace Wages\n\nThe Pulse of the Purchaser 2024 survey published this week by National Alliance of Healthcare Purchaser Coalitions reveals that escalating health care costs are prompting employers to explore cost-management strategies that balance employee benefits with organizational sustainability. With 74% of employers concerned about the impact of rising health care costs on wages and benefits, many are considering shifts in cost sharing with employees and implementing targeted initiatives for high-cost claims, such as managed maternity benefits, early screening, and site-of-care redirection. Additionally, employers are prioritizing health equity, with 74% engaging in cross-departmental discussions on the topic and analyzing data to address disparities. The survey also highlights dissatisfaction with current pharmacy benefits manager practices, with over half of respondents considering a change to improve transparency and control.\n\n\n\nContributor: Vulnerable Seniors Are at Risk With Looming Medicare Advantage Cuts—Income-Based Programs Can Minimize the Damage\n\nThe 2024 Medicare Advantage (MA) open enrollment period reveals significant challenges for beneficiaries as regulatory changes and financial pressures force MA plans to cut benefits and raise costs. With an average of 43 MA options, many seniors face plan disruptions, with 1.38 million losing access to their current plan and 4.56 million automatically moving to new plans. Key changes include increased Part D deductibles, reduced supplemental benefits like Flex Card allowances and over-the-counter coverage, and increased premiums, leaving many beneficiaries—particularly low-income seniors—at risk of higher out-of-pocket expenses. Income-based programs such as Medicaid could help alleviate these costs, but up to half of eligible seniors remain unenrolled. As seniors navigate these changes, using resources like the Medicare Advantage Annual Enrollment period checklist and external advisors may help them better understand their options and secure necessary benefits amidst the shifting landscape.\n\n\n\nNew AI Tool Identifies Undiagnosed PNH in Health Records\n\nA recent study investigated using a machine learning model to help identify undiagnosed cases of paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder with high misdiagnosis rates due to its varied symptoms. The algorithm analyzed electronic health records data from the Optimum Patient Care Research Database, distinguishing PNH cases with significant specificity and accuracy by focusing on key clinical markers associated with PNH, such as aplastic anemia and hemolytic anemia. The initial Positive Predictive Value (PPV) was 60.4% (95% CI, 33% to 82%), indicating that over half of the flagged patients already had a PNH diagnosis in their records. However, when researchers adjusted for PNH’s rarity (3.81 cases per 100,000 individuals), the PPV decreased to 19.59% (95% CI, 7.63% to 41.81%), suggesting that approximately 1 in 5 flagged patients may need further investigation for PNH. The study’s findings underscore the potential of machine learning to improve early diagnosis of rare diseases, though additional testing on diverse datasets is required for clinical application.\n\n\n\nBiosimilars Expand Access and Reduce Costs in Oncology, Immunology\n\nNew research presented at the Academy of Managed Care Pharmacy (AMCP) Nexus highlights the cost savings and access benefits of biosimilars in health care. With over 60 biosimilars approved in the US, these alternatives offer significant savings, especially in costly treatment areas like immunomodulation, oncology, and endocrinology. Studies showed biosimilars such as denosumab and adalimumab enable substantial budget-neutral savings, thereby expanding treatment access and promoting health equity. For example, a projected 70% adoption of biosimilar denosumab could save over $31 million in 5 years. Similarly, adalimumab biosimilars, with costs up to 80% lower than Humira (adalimumab), could extend access to treatments for chronic inflammatory conditions. This real-world evidence suggests biosimilars' growing role in reducing health care costs while broadening patient access to essential therapies.","description":"This week’s Center on Health Equity & Access highlights emphasize the role of social determinants of health in policy-making and underscore the importance of addressing rising costs and challenges employers face.\n","author":[{"@type":"Person","name":"Giuliana Grossi"}]}</script></div></div><div class="flex-none w-[300px] z-[9999] relative hidden md:block"><div style="top:5rem" class="sticky custom-spacing"><div class="collapse-container " style="overflow:hidden;max-height:900px;transition:max-height .4s ease-in-out"></div></div></div></div><div id="div-gpt-ad-pixel" style="width:1px;height:1px" class=""></div><noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NK5KQXS" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript><div id="footerOuterWrap" class=" mx-auto flex"><div 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With over 60 biosimilars approved in the US, these alternatives offer significant savings, especially in costly treatment areas like immunomodulation, oncology, and endocrinology. Studies showed biosimilars such as denosumab and adalimumab enable substantial budget-neutral savings, thereby expanding treatment access and promoting health equity. For example, a projected 70% adoption of biosimilar denosumab could save over $31 million in 5 years. Similarly, adalimumab biosimilars, with costs up to 80% lower than Humira (adalimumab), could extend access to treatments for chronic inflammatory conditions. This real-world evidence suggests biosimilars' growing role in reducing health care costs while broadening patient access to essential therapies.","_key":"102437af3520","_type":"span"}],"_type":"block","style":"normal"}],"seoTag":["Health Equity","Health Policy","Healthcare Coverage"],"_updatedAt":"2024-11-01T19:12:32Z","issueSection":null,"thumbnail":{"_type":"mainImage","alt":"Center on Health Equity and Access","asset":{"_ref":"image-1fb0458d4007f177c86e1a37a8c9d4ba60b1f084-303x160-jpg","_type":"reference"}},"_type":"article","title":"Health Equity \u0026 Access Weekly Roundup: November 2, 2024","pdfUrl":null,"drugMentions":"{\n \"drug_mentions\": [\"denosumab\", \"adalimumab\", \"Humira\"]\n}","articleType":"News","authorMapping":[{"_createdAt":"2023-06-23T19:52:20Z","_rev":"sgy4yN0CjmArmRDnE2KYhI","_type":"author","_id":"8e597e29-c3ad-470c-8174-00c81b563f81","profileImage":{"_type":"mainImage","alt":"Giuliana Grossi","asset":{"_ref":"image-5dc1da24786c43a7f87e4ea0a7ae3880e6cee39f-430x430-png","_type":"reference"}},"_updatedAt":"2024-05-20T19:25:19Z","url":{"current":"giuliana-grossi","_type":"slug"},"displayName":"Giuliana Grossi"}],"is_visible":true,"_rev":"IlIq0JCGGmrvSiDdugOkDD","published":"2024-11-02T13:00:00.000Z","documentGroupMapping":null,"ExcludeFromPubMedXML":false,"summary":"This week’s Center on Health Equity \u0026 Access highlights emphasize the role of social determinants of health in policy-making and underscore the importance of addressing rising costs and challenges employers face.\n","filter":null,"url":{"current":"health-equity-access-weekly-roundup-november-2-2024","_type":"slug"},"gptSummary":"Efforts to address social determinants of health (SDOH) face challenges, including limited evidence on return on investment. Initiatives like CMMI's Accountable Health Communities model aim to integrate healthcare and social services, but implementation hurdles persist. Employers are adopting equity-focused strategies to manage rising healthcare costs, with many considering changes to pharmacy benefits management. Medicare Advantage beneficiaries face plan disruptions due to regulatory changes, with income-based programs offering potential relief. Biosimilars are expanding access and reducing costs in oncology and immunology, while AI tools show promise in identifying undiagnosed rare diseases.","contentGroup":null,"factCheckAuthorMapping":null,"issueGroup":null,"_createdAt":"2024-11-01T18:19:02Z","contentCategory":{"_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","name":"Articles"},"taxonomyMapping":[{"pixelTrackingCode":null,"_rev":"OU32WOWh4YetHW0RkWbkso","name":"News","_id":"39be7351-bd4c-4e98-82b3-0d675ae4671b","parent":null,"identifier":"news","_createdAt":"2020-03-30T18:05:45Z","_type":"taxonomy","_updatedAt":"2022-01-19T10:20:16Z"},{"_type":"taxonomy","parent":{"identifier":"topic","isMainTopic":true,"_rev":"SpZIJtjiAn4ebHE4u6sWYc","_type":"taxonomy","name":"Topic","_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","_createdAt":"2020-03-31T14:24:50Z","parent":null},"_updatedAt":"2024-06-12T13:58:15Z","_id":"4ee49086-e720-4a65-883e-4efc24de53bb","summary":[{"disableLightBox":true,"_type":"figure","_key":"3b7c1e2bf551","alignment":"left","asset":{"_ref":"image-5f5a1d7609b5e2167e8398bb48c8734b1ba7aca8-800x212-jpg","_type":"reference"},"widthP":70,"disableTextWrap":false},{"style":"normal","_key":"973bcb0dcce4","markDefs":[],"children":[{"marks":[],"text":"The mission of the Center on Health Equity \u0026 Access is to support improvement of health care delivery and health outcomes due to health disparities by maintaining a content platform focused on education, training, frontline perspectives, and practical application of evidence-based methodologies.","_key":"cdef2f34ef460","_type":"span"}],"_type":"block"}],"_rev":"N7mKycgLbGtEq6btkPHYvR","pixelTrackingCode":null,"identifier":"center-on-health-equity-and-access","_createdAt":"2022-11-16T22:15:20Z","name":"Center on Health Equity \u0026 Access","thumbnail":{"alt":"Logo for the Center on Health Equity \u0026 Access","asset":{"_ref":"image-5f5a1d7609b5e2167e8398bb48c8734b1ba7aca8-800x212-jpg","_type":"reference"},"_type":"mainImage"},"usedForRecommendations":false},{"_createdAt":"2020-05-04T23:46:13Z","_type":"taxonomy","parent":{"isMainTopic":true,"_createdAt":"2020-03-31T14:24:50Z","_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","identifier":"topic","_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic","parent":null},"_updatedAt":"2022-11-29T18:34:57Z","identifier":"healthcare-delivery","_rev":"52vAUxG62nnEnK65ZDo5dG","pixelTrackingCode":null,"name":"Health Care Delivery","_id":"topic_healthcare-delivery"},{"_updatedAt":"2020-07-30T14:47:46Z","pixelTrackingCode":null,"parent":{"_createdAt":"2020-03-31T14:24:50Z","_type":"taxonomy","_updatedAt":"2021-10-21T10:15:35Z","identifier":"topic","isMainTopic":true,"parent":null,"_id":"15012229-f713-4f0a-8f82-7667530bb382","_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic"},"_createdAt":"2020-05-04T23:46:13Z","name":"Policy","_id":"topic_policy","identifier":"policy","_rev":"GQ2iWOdzjKwgYpKUFVt5oL","_type":"taxonomy"},{"_id":"topic_insurance","_updatedAt":"2020-07-30T14:47:46Z","identifier":"insurance","_type":"taxonomy","name":"Insurance","parent":{"_updatedAt":"2021-10-21T10:15:35Z","_createdAt":"2020-03-31T14:24:50Z","name":"Topic","identifier":"topic","isMainTopic":true,"_rev":"SpZIJtjiAn4ebHE4u6sWYc","_type":"taxonomy","_id":"15012229-f713-4f0a-8f82-7667530bb382","parent":null},"_createdAt":"2020-05-04T23:46:13Z","_rev":"GQ2iWOdzjKwgYpKUFVt5oL","pixelTrackingCode":null},{"_type":"taxonomy","name":"Health Care Cost","_updatedAt":"2022-11-29T18:34:38Z","parent":{"_type":"taxonomy","parent":null,"_id":"15012229-f713-4f0a-8f82-7667530bb382","_updatedAt":"2021-10-21T10:15:35Z","isMainTopic":true,"_rev":"SpZIJtjiAn4ebHE4u6sWYc","name":"Topic","identifier":"topic","_createdAt":"2020-03-31T14:24:50Z"},"_createdAt":"2020-05-04T23:46:13Z","_rev":"52vAUxG62nnEnK65ZDnwlC","_id":"topic_healthcare-cost","identifier":"healthcare-cost","pixelTrackingCode":null}],"disableAds":false,"disableRelatedContent":false,"relatedArticles":[{"authorMapping":[{"_type":"author","_id":"8e597e29-c3ad-470c-8174-00c81b563f81","profileImage":{"_type":"mainImage","alt":"Giuliana Grossi","asset":{"_ref":"image-5dc1da24786c43a7f87e4ea0a7ae3880e6cee39f-430x430-png","_type":"reference"}},"_updatedAt":"2024-05-20T19:25:19Z","url":{"current":"giuliana-grossi","_type":"slug"},"displayName":"Giuliana Grossi","_createdAt":"2023-06-23T19:52:20Z","_rev":"sgy4yN0CjmArmRDnE2KYhI"}],"published":"2024-11-27T20:13:49.018Z","gptSummary":"The stimulant medication shortage has highlighted significant challenges in ADHD treatment, particularly for adults. Rising diagnoses, stigma, and inadequate clinical guidance complicate care, while medication shortages exacerbate access issues. Despite increased production quotas for medications like Vyvanse, supply remains insufficient due to DEA-imposed caps. Critics argue these quotas are overly restrictive and fail to adapt to rising demand, primarily affecting patients with ADHD. The DEA's focus on preventing misuse is seen as a barrier to addressing the shortage, with calls for reform to prioritize patient needs.","url":"us-adhd-stimulant-shortage-highlights-growing-challenges-in-adult-treatment","audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/69734b3f-fc02-41a3-9dbd-b9600a54d963_1732738433064.d2d61350-7dcf-4ce1-a494-553413baf358.mp3","summary":"While name brands like Adderall and Vyvanse may have been recently removed from the FDA Drug Shortage Database, it's unclear if it'll last; meanwhile, many generic forms of attention-deficit/hyperactivity disorder (ADHD) medication are still in short supply.","thumbnail":{"alt":"medicine pills - Kwangmoozaa - stock.adobe.com.jpeg","asset":{"_type":"reference","_ref":"image-b6fb5039fb065b6265bd44eb4eb365c5b2c92738-3115x2076-jpg"},"_type":"mainImage"},"_type":"article","authors":[{"displayName":"Giuliana Grossi","url":"giuliana-grossi"}],"documentGroup":null,"_updatedAt":"2024-11-27T20:13:57Z","title":"US ADHD Stimulant Shortage Highlights Growing Challenges in Adult Treatment","contentCategory":{"_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2","_updatedAt":"2023-09-29T14:32:27Z"},"articleType":"News","factCheckAuthorMapping":null,"documentGroupMapping":null,"_createdAt":"2024-11-27T16:39:47Z","is_visible":true,"gptTakeaways":"• The stimulant shortage reveals critical gaps in ADHD treatment, especially for adults, with rising diagnoses and limited clinical guidance complicating care.\n\n• Despite increased production quotas, DEA-imposed caps restrict supply, failing to meet rising demand for ADHD medications.\n\n• Critics argue DEA quotas are overly restrictive, hindering access for patients with ADHD and exacerbating the shortage.\n\n• Calls for DEA reform emphasize prioritizing patient needs over concerns about misuse, aiming to resolve the ongoing medication shortage.","_rev":"fWx7QmWGimMXMJ6HKQ76wG","_id":"69734b3f-fc02-41a3-9dbd-b9600a54d963","ExcludeFromPubMedXML":false,"factCheckAuthors":null,"body":[{"_type":"figure","alignment":"right","disableTextWrap":false,"widthP":38,"alt":"medicine pills - Kwangmoozaa - stock.adobe.com.jpeg","imgcaption":[{"_type":"block","style":"normal","_key":"3ac440db751e","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Accessing ADHD treatment presents numerous challenges for many adults. | Image Credit: © Kwangmoozaa - stock.adobe.com","_key":"e4d17b2d41c6"}]}],"_key":"74129970b736","disableLightBox":true,"asset":{"_ref":"image-b6fb5039fb065b6265bd44eb4eb365c5b2c92738-3115x2076-jpg","_type":"reference"}},{"_type":"block","style":"normal","_key":"dfb6f597bce6","markDefs":[],"children":[{"_key":"2f160bf88c0b0","_type":"span","marks":[],"text":"The ongoing shortage of stimulant medications has exposed critical gaps in the treatment of attention-deficit/hyperactivity disorder (ADHD), particularly for adults, in whom rising diagnoses, stigma, and limited clinical guidance complicate care."},{"_type":"span","marks":["superscript"],"text":"1","_key":"36257bea91f7"},{"text":" Patients face mounting barriers to care, highlighting the urgent need for improved diagnostics, evidence-based guidelines, and equitable access to medications.","_key":"2b26c972b206","_type":"span","marks":[]}]},{"markDefs":[],"children":[{"_key":"df0a9ec0f81d","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"8928a23a4707"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"While name brands like Adderall and Vyvanse may have been recently removed from the FDA Drug Shortage Database, it's unclear if it'll last; meanwhile, many generic forms of ADHD medication are still in short supply.","_key":"79c9822935cc"},{"_type":"span","marks":["superscript"],"text":"2,3","_key":"b3f405bb57e2"}],"_type":"block","style":"normal","_key":"aec75ef587c9"},{"style":"normal","_key":"4c0b5fe18994","markDefs":[],"children":[{"_type":"span","marks":["superscript"],"text":"","_key":"eeb1629ff381"}],"_type":"block"},{"_key":"5525ba62f2f2","markDefs":[{"href":"https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2825280","_key":"be1f46f5f3e2","nofollow":true,"blank":true,"_type":"link"}],"children":[{"text":"The COVID-19 pandemic has reshaped trends in ADHD treatment, with heightened demands on attention and expanded access to telehealth contributing to an increase in adult diagnoses, according to an article in ","_key":"59bfd12c96550","_type":"span","marks":[]},{"_type":"span","marks":["em","be1f46f5f3e2"],"text":"JAMA Psychiatry","_key":"67a5fd547f7d"},{"marks":[],"text":".","_key":"e41352e79124","_type":"span"},{"text":"1","_key":"0f24209a1b34","_type":"span","marks":["superscript"]},{"_key":"2643ce3ee50b","_type":"span","marks":[],"text":" However, diagnosing ADHD in adults remains complex. Originally perceived as a childhood disorder, ADHD is now recognized as a lifelong condition, affecting an estimated 2.5% to 4% of adults in the US and costing over $100 billion annually. "}],"_type":"block","style":"normal"},{"style":"normal","_key":"4b5e052d5313","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"517cf6af732e"}],"_type":"block"},{"markDefs":[],"children":[{"text":"Diagnostic criteria—adapted from pediatric guidelines—may not adequately capture adult-specific symptoms, such as deficits in executive function or challenges in emotional regulation. This can lead to potential misdiagnosis or underdiagnosis, the authors explained.","_key":"4ce07470b51d","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"2c32d82ee491"},{"style":"normal","_key":"e187f291d547","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"3b012f74fcee"}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"Accessing treatment presents numerous challenges for many adults. Concerns about medication misuse, social stigma, and a lack of long-term data on treatment outcomes complicate care. Another challenge is that health systems, clinicians, and policy makers are grappling with how to balance the benefits of effective treatment against the risks of diversion and stimulant use disorder. ","_key":"30223e6e6e06"}],"_type":"block","style":"normal","_key":"178aba3450e2","markDefs":[]},{"_type":"block","style":"normal","_key":"b59a9a26aff6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ce57644173fb"}]},{"_key":"11a5800c1fb6","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Stimulants are widely regarded as the most effective treatment for ADHD, although nonstimulants and behavioral therapies are often underutilized, the authors argued. The absence of evidence-based treatment guidelines further undermines clinicians’ confidence in prescribing, resulting in risks of both overtreatment and undertreatment. Moreover, medication shortages have highlighted disparities in access to care. ","_key":"8afe79205613"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"","_key":"89afb5683ca2"}],"_type":"block","style":"normal","_key":"f147de34f907","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"In September, the federal Drug Enforcement Agency (DEA) approved a production increase for Vyvanse (lisdexamfetamine) and its generic equivalents, raising the aggregate production quota (APQ) for the stimulant medication by approximately 24%.","_key":"07604e9633430"},{"_type":"span","marks":["superscript"],"text":"4","_key":"1b254f35d9ac"},{"_type":"span","marks":[],"text":" This decision aimed to address the rising demand for ADHD and binge-eating disorder treatments. ","_key":"6dfea327d993"}],"_type":"block","style":"normal","_key":"491b229c0225"},{"children":[{"text":"","_key":"ca377fd0f867","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"d1b3abffba06","markDefs":[]},{"style":"normal","_key":"f66566596407","markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, discussions on the topic haven't led to confidence in the ability to significantly alleviate the ongoing stimulant shortage, with many largely attributing the issue to DEA-imposed production caps.","_key":"58d580d153f0"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"6ff0d10f3883"}],"_type":"block","style":"normal","_key":"96ede933f1bc"},{"children":[{"text":"Vyvanse, which became available as a generic in August 2023, converts to dextroamphetamine in the body, the same active ingredient in Adderall. While the DEA also raised the APQ for dextroamphetamine by 18%, only about 25% of the increased quota will be allocated for domestic use, equating to just a 6.5% rise in lisdexamfetamine supply for the US. Despite higher demand—estimated by the FDA to have grown 6% from 2023 to 2024—the production adjustment falls short of bridging the supply gap.","_key":"5c59c256d39b0","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"62ef3d0b65df","markDefs":[]},{"children":[{"_type":"span","marks":[],"text":"","_key":"ac186627d64a"}],"_type":"block","style":"normal","_key":"ba9c4739cd48","markDefs":[]},{"_key":"acc3481c0c81","markDefs":[],"children":[{"_key":"60e3f12555b90","_type":"span","marks":[],"text":"The stimulant shortage began with Adderall supply issues in October 2022 and has since impacted other ADHD medications like Vyvanse and Ritalin. Although some Adderall manufacturers, like Teva Pharmaceuticals, have made progress in recovering inventory, Vyvanse's manufacturers and its generics face persistent challenges. The DEA’s caps on dextroamphetamine, cited as the primary reason for shortages, limit manufacturers’ ability to meet demand even after Vyvanse’s patent expired and generic versions became available."}],"_type":"block","style":"normal"},{"_key":"4d1407432ae1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"c97d692d3e74"}],"_type":"block","style":"normal"},{"children":[{"_key":"ef0728034da70","_type":"span","marks":[],"text":"The DEA and FDA have acknowledged the challenges but emphasize their limited authority, stating they cannot mandate pharmaceutical companies to produce more or alter distribution practices. Critics argue that the DEA’s yearly quotas, described as arbitrary and restrictive, are a root cause of the ongoing shortages. Adjustments to these caps, they claim, could resolve the supply issues without requiring additional regulatory intervention."}],"_type":"block","style":"normal","_key":"9995a5001a71","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"eb3cb1f1fcc0"}],"_type":"block","style":"normal","_key":"f3d653f73090"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"However, William Dodson, MD, LF-APA, stated in a blog post for ADDitude that the system utilized by the DEA is designed to combat potential abuse and, therefore, is inflexible and unable to adapt to changing patient needs.","_key":"922c166c647c"},{"_type":"span","marks":["superscript"],"text":"5","_key":"0abe7a7b0cf5"},{"_type":"span","marks":[],"text":" The DEA establishes annual production caps for each pharmaceutical company based on predictions made nearly 2 years in advance.","_key":"221abc48d9f1"}],"_type":"block","style":"normal","_key":"4e066100115d"},{"style":"normal","_key":"86d0fe6057a9","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"b961cc998cd7"}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"\"By inviting public testimony on the stimulant shortage and pharmaceutical practices, I believe the FTC [Federal Trade Commission] is only trying to find cover for the [DEA],\" Dodson wrote. \"The DEA is the only governmental agency that sets production and distribution quotas for every drug company manufacturing controlled medication. The DEA decides how much of each medication can be released to pharmacies in any given month. Therefore, this problem traces its roots and long tendrils back to the DEA alone. No other agency has the authority to create and prolong it.\"","_key":"404e272771cc0"}],"_type":"block","style":"normal","_key":"b1ae7a627aa3"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"8bc71841299b"}],"_type":"block","style":"normal","_key":"bdcc2f225395"},{"_type":"block","style":"normal","_key":"05b94ad3b5df","markDefs":[],"children":[{"_key":"19b6c6ea1b38","_type":"span","marks":[],"text":"Critics noted that the DEA’s 2022 decision to impose tighter quotas on ADHD medications stemmed from concerns about diversion and misuse—despite limited evidence supporting these claims. Dodson further explained that research has suggested that most stimulant misuse occurs among a narrow demographic of white male college students, not individuals with ADHD, who rely on these medications for daily functioning."}]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"d1a80a9ef2da"}],"_type":"block","style":"normal","_key":"5044ed86609a"},{"children":[{"_type":"span","marks":[],"text":"The shortage worsened as the DEA restricted supply following a surge in adult ADHD diagnoses. Despite well-documented evidence that ADHD persists into adulthood, the DEA’s response seemingly ignored this reality, reducing medication availability as demand grew.","_key":"37b5fd52f1830"}],"_type":"block","style":"normal","_key":"978909f52395","markDefs":[]},{"markDefs":[],"children":[{"_key":"062e6503179a","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"a5dbd6da9093"},{"_key":"bdf88447637b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Initially, the DEA and other agencies, including the FDA and FTC, attributed the shortage to manufacturing and raw material shortages. However, pharmaceutical companies have consistently stated they are producing as much as the DEA permits. Telemedicine clinics, cited as a contributing factor during the pandemic, accounted for only a fraction of prescriptions and have largely ceased operations. Despite these deflections, the shortage remains unresolved, causing significant disruption for patients reliant on these medications.","_key":"abea1b0769fe0"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"text":"","_key":"7c9490c94690","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"f4d3d8a77e68"},{"_type":"block","style":"normal","_key":"bc1b2fee7bcc","markDefs":[],"children":[{"_key":"2aa61690976d0","_type":"span","marks":[],"text":"Critics call for the DEA to overhaul its flawed quota system and prioritize patient needs over unfounded concerns about abuse. Without swift action, the shortage will persist into 2025, prolonging unnecessary suffering for millions. 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Reach out to Kaitlyn Musessen, Strategic Alliance Partnership Manager, to learn more about the complimentary strategic partnership program at ","_key":"396b2937ee990","_type":"span","marks":[]},{"_key":"396b2937ee991","_type":"span","marks":["11fbb665436a"],"text":"kmuessen@ajmc.com"},{"_type":"span","marks":[],"text":".","_key":"396b2937ee992"}]}],"identifier":"partners","_id":"79d0e66d-290c-469d-83ba-cdf51b402811","_createdAt":"2020-03-30T20:05:38Z","_rev":"0ipl08B5ODVfYzMvbanU6U","_type":"taxonomy","parent":null,"pixelTrackingCode":null,"name":"SAP Partners"}],"body":[{"children":[{"marks":[],"text":"With disappointing findings on the ability of consolidation durvalumab to produce positive outcomes among patients being treated for unresectable stage III ","_key":"7f952a0cdd290","_type":"span"},{"_type":"span","marks":["b5e46a6f3a8a"],"text":"non–small cell lung cancer","_key":"7f952a0cdd291"},{"_key":"7f952a0cdd292","_type":"span","marks":[],"text":" (NSCLC), investigators of a new study "},{"_type":"span","marks":["e8dd82e648bc"],"text":"published in ","_key":"7f952a0cdd293"},{"_type":"span","marks":["e8dd82e648bc","em"],"text":"PLoS ONE","_key":"7f952a0cdd294"},{"_type":"span","marks":[],"text":" are saying that treatment strategies that involve the immune checkpoint inhibitor need to be refined due to unmet medical needs.","_key":"7f952a0cdd295"},{"text":"1","_key":"7f952a0cdd296","_type":"span","marks":["superscript"]}],"_type":"block","style":"normal","_key":"4e2f595cf70c","markDefs":[{"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/nsclc","_key":"b5e46a6f3a8a"},{"href":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314156","_key":"e8dd82e648bc","nofollow":true,"blank":true,"_type":"link"}]},{"children":[{"marks":[],"text":"","_key":"38697368c6e20","_type":"span"}],"_type":"block","style":"normal","_key":"379413741864","markDefs":[]},{"markDefs":[],"children":[{"marks":[],"text":"The historic standard of care for unresectable stage III NSCLC was platinum-based chemotherapy and concurrent radiotherapy (cCRT) and surveillance, the authors note.","_key":"3d319b0dca9c0","_type":"span"},{"_type":"span","marks":["superscript"],"text":"2","_key":"3d319b0dca9c1"},{"_type":"span","marks":[],"text":" Yet, approximately half of patients go on to develop distant metastases,","_key":"3d319b0dca9c2"},{"_key":"3d319b0dca9c3","_type":"span","marks":["superscript"],"text":"3"},{"_key":"3d319b0dca9c4","_type":"span","marks":[],"text":" and the 5-year overall survival rate is a dismal 37%."},{"_type":"span","marks":["superscript"],"text":"4","_key":"3d319b0dca9c5"},{"_type":"span","marks":[],"text":" Noting the difficulty of treating disease in these patients, they highlight how their findings show the regimen is underutilized despite known benefits, with 4 of 10 patients eligible for consolidation durvalumab not receiving it.","_key":"3d319b0dca9c6"},{"_type":"span","marks":["superscript"],"text":"1","_key":"b69ae3b05bb0"}],"_type":"block","style":"normal","_key":"858ea5a5fcb3"},{"_type":"block","style":"normal","_key":"233657e4c078","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"040c5dbc006d0"}]},{"style":"normal","_key":"e56b3e019e61","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Durvalumab, an immune checkpoint inhibitor (ICI), was first approved for use in the US as consolidation therapy after cCRT without disease progression in May 2017","_key":"7d9f8efb4e8f0"},{"marks":["superscript"],"text":"5","_key":"7d9f8efb4e8f1","_type":"span"},{"_key":"7d9f8efb4e8f2","_type":"span","marks":[],"text":" and in the European Union in September 2018."},{"_type":"span","marks":["superscript"],"text":"6","_key":"7d9f8efb4e8f3"},{"_type":"span","marks":[],"text":" Most recently, it was approved in the US for use in combination with chemotherapy for resectable early-stage disease.","_key":"7d9f8efb4e8f4"},{"_type":"span","marks":["superscript"],"text":"7","_key":"7d9f8efb4e8f5"}],"_type":"block"},{"_type":"block","style":"normal","_key":"d713b82bbda9","markDefs":[],"children":[{"text":"","_key":"9c7e8d678f620","_type":"span","marks":[]}]},{"markDefs":[],"children":[{"_key":"af3af6bde8360","_type":"span","marks":[],"text":"Due to limited evidence in a real-world setting on consolidation durvalumab’s use for patients with unresectable stage III NSCLC,"},{"_type":"span","marks":["superscript"],"text":"1","_key":"af3af6bde8361"},{"_key":"af3af6bde8362","_type":"span","marks":[],"text":" the author sought a greater understanding of its treatment patterns and clinical outcomes in community oncology practices. For their retrospective observational analysis, they used data on newly diagnosed patients from The US Oncology Network’s electronic health record; their treatment window encompassed patients who received their diagnosis and initiated cCRT between November 1, 2017, and October 31, 2019, and who were followed through April 30, 2022. cCRT was defined as “radiotherapy received +/-14 days of receipt of the first dose of chemotherapy.”"}],"_type":"block","style":"normal","_key":"ae39d66391b5"},{"_key":"eac751ebfd41","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"e4a28394c1170"}],"_type":"block","style":"normal"},{"alt":"Lungcancertreatment | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","imgcaption":[{"markDefs":[],"children":[{"marks":[],"text":"The most recent US approval for durvalumab came in August, when it was approved for use in combination with chemotherapy for resectable early-stage disease. | Image Credit: © Vitalii Vodolazskyi-stock.adobe.com","_key":"2902075f001d0","_type":"span"}],"_type":"block","style":"normal","_key":"97e4882ba2ed"}],"asset":{"_ref":"image-20805afe527369d997c10f03a2d5ac2e3a49f2a3-1200x738-jpg","_type":"reference"},"widthP":40,"disableTextWrap":false,"_type":"figure","disableLightBox":true,"alignment":"right","_key":"d44448c3b780"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"Of the 540 patients included in this study, 61.5% (n = 262) received durvalumab following cCRT and 38.5% (n = 164) only received cCRT. Their median (IQR) age was 70.6 (63.7-76.3) years, less than half (44.6%) were female patients, most reported a White race (72.3%), the median body mass index was 25.4 (22.3-28.7) mg/m","_key":"da376202c85e0"},{"_type":"span","marks":["superscript"],"text":"2","_key":"a9b889930af2"},{"_type":"span","marks":[],"text":", 57.3% were former smokers, 52.8% had diagnosed nonsquamous histology, and 67.8% had an ECOG performance status of 0 to 1.","_key":"4b3813b52878"}],"_type":"block","style":"normal","_key":"3e0d3a9bbcfe"},{"style":"normal","_key":"329df61a629e","markDefs":[],"children":[{"text":"","_key":"1b7962b2e3df0","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"With the index date being initiation of cCRT after confirmed diagnosis, the investigators saw that patients who received cCRT and durvalumab had the longest median follow-up after the index date and those who only received cCRT, the shortest: 30.4 (13.5-38.0) vs 6.0 (2.6-15.1) months. Carboplatin plus paclitaxel was the most common chemotherapy regimen across both patient groups (86.6%, cCRT and durvalumab; 90.9%, cCRT alone).","_key":"1d97c9cec9fb0"}],"_type":"block","style":"normal","_key":"801237205efb"},{"_type":"block","style":"normal","_key":"ec9013b3ffa3","markDefs":[],"children":[{"text":"","_key":"0ec3a642d09a0","_type":"span","marks":[]}]},{"style":"normal","_key":"0e8853a10621","markDefs":[],"children":[{"text":"However, more patients who received cCRT and durvalumab vs cCRT alone experienced disease progression (41.6% vs 31.3%). Among these patients, most in the former group next received an ICI in combination (37.1%) whereas those in the latter group most often received a chemotherapy combination (46.5%). The most common documented reasons for not receiving consolidation durvalumab were death (28.3%) or disease progression (22.2%), and for discontinuing durvalumab before completing all treatments, adverse events (35.8%) or disease progression (28.4%).","_key":"12e9ab3703c90","_type":"span","marks":[]}],"_type":"block"},{"markDefs":[],"children":[{"_key":"1caca4dc6b920","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"f90220751077"},{"_type":"block","style":"normal","_key":"27fd570db851","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Among patients who received durvalumab after cCRT, the median real-world overall survival (rwOS) was 50.2 (95% CI, 41.4–not reached [NR]) months, and the 12-month survival rate, 83.6% (95% CI, 78.4%-87.6%). The corresponding totals for those who only received cCRT were 11.6 (95% CI, 6.5-15.9) months and 49.1% (95% CI, 40.4%-57.2%). In particular, among those who received consolidation durvalumab, their rwOS was 46.6 (95% CI, 38.3-NR) months and 12-month survival rate, 78.2% (95% CI, 72.5%-82.8%), after consolidation initiation.","_key":"9683623fb2ee0"}]},{"_type":"block","style":"normal","_key":"f76f6925d095","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"4060d14539700"}]},{"children":[{"_type":"span","marks":[],"text":"Throughout the study observation period, an overall 60.8% had disease progression or died; this was lower in those who received consolidation durvalumab after cCRT vs cCRT alone: 56.5% vs 67.7%. Median real-world progression-free survival (rwPFS) was 28.5 (95% CI, 23.3-36.4) and 6.3 (95% CI, 4.3-9.3) months, respectively, from the index date, and 12-month rwPFS probability, 72.2% (95% CI, 66.3%-77.2%) and 35.0% (95% CI, 27.1%-43.0%). From start of consolidation durvalumab, median rwPFS was 25.4 (95% CI, 20.7-32.7) months, and the 12-month PFS probability, 65.8% (95% CI, 59.7%-71.3%).","_key":"fbb47bec71d60"}],"_type":"block","style":"normal","_key":"61c7e0cf1447","markDefs":[]},{"children":[{"_key":"f9e5eed463c10","_type":"span","marks":[],"text":""}],"_type":"block","style":"normal","_key":"53d27b252b97","markDefs":[]},{"_key":"b93e854d8dd7","markDefs":[],"children":[{"_type":"span","marks":[],"text":"Strengths of these findings are that the data on underutilization of durvalumab from death or disease progression and treatment discontinuation echo previous research, which the authors note “suggest the need for more effective induction therapy for patients with unresectable stage III NSCLC, to allow a greater number of these patients to have stable disease and continue consolidation treatment.” They also highlight gaps in treatment strategies for ICIs that serve to strengthen treatment adherence and outcomes.","_key":"1de91c8adb830"}],"_type":"block","style":"normal"},{"_key":"59be840443d2","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"fe8129f8f6c60"}],"_type":"block","style":"normal"},{"markDefs":[],"children":[{"marks":[],"text":"“While durvalumab addresses a critical need for patients with unresectable stage III NSCLC,” they concluded, “our study underscores the need for additional treatment strategies to address the limitations of consolidation treatment with ICI therapy and explore the best mode of application of ICI in this patient population.”","_key":"97199f3724390","_type":"span"}],"_type":"block","style":"normal","_key":"7c213209f3f7"},{"markDefs":[],"children":[{"marks":[],"text":"","_key":"9ecb527029880","_type":"span"}],"_type":"block","style":"normal","_key":"bcb0a8346411"},{"markDefs":[],"children":[{"_type":"span","marks":["strong"],"text":"References","_key":"fddbb99b973c0"}],"_type":"block","style":"normal","_key":"e6dadd68dcbc"},{"children":[{"_type":"span","marks":[],"text":"1. Arunachalam A, Sura S, Murphy J, Conkling P, Goldschmidt J. Real-world treatment patterns and outcomes among unresectable stage III non-small cell lung cancer.","_key":"f70047757b270"},{"_type":"span","marks":["em"],"text":" PLoS One","_key":"f70047757b271"},{"_type":"span","marks":[],"text":". 2024;19(11):e0314156. doi:10.1371/journal.pone.0314156","_key":"f70047757b272"}],"_type":"block","style":"normal","_key":"5dc61260028e","markDefs":[]},{"_key":"286ca021cb06","markDefs":[],"children":[{"_type":"span","marks":[],"text":"2. Auperin A, Le Pechoux C, Rolland E, et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. ","_key":"caa8b5ee7ba50"},{"text":"J Clin Oncol","_key":"caa8b5ee7ba51","_type":"span","marks":["em"]},{"marks":[],"text":". 2010;28(13):2181-2190. doi:10.1200/JCO.2009.26.2543","_key":"caa8b5ee7ba52","_type":"span"}],"_type":"block","style":"normal"},{"children":[{"_type":"span","marks":[],"text":"3. Bradley JD, Hu C, Komaki RR, et al. Long-term results of NRG Oncology RTOG 0617: standard- versus high-dose chemoradiotherapy with or without cetuximab for unresectable stage iii non-small-cell lung cancer. ","_key":"7316855e7b520"},{"_type":"span","marks":["em"],"text":"J Clin Oncol","_key":"7316855e7b521"},{"_type":"span","marks":[],"text":". 2020;38(7):706-714. doi:10.1200/JCO.19.01162","_key":"7316855e7b522"}],"_type":"block","style":"normal","_key":"915e7ff98b07","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"4. Albain KS, Swann RS, Rusch VW, Turrisi AT 3rd, Shepherd FA, Smith C, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomized controlled trial. ","_key":"3d865dc3fb650"},{"_type":"span","marks":["em"],"text":"Lancet","_key":"3d865dc3fb651"},{"_type":"span","marks":[],"text":". 2009;374(9687):379-386. doi:10.1016/S0140-6736(09)60737-6","_key":"3d865dc3fb652"}],"_type":"block","style":"normal","_key":"c48892b5a99c"},{"markDefs":[{"nofollow":true,"blank":true,"_type":"link","href":"https://www.drugs.com/history/imfinzi.html#:~:text=FDA%20Approved:%20Yes%20(First%20approved,Tumor%2C%20Hepatocellular%20Carcinoma%2C%20Endometrial%20Cancer","_key":"aac2431f7fc2"}],"children":[{"marks":[],"text":"5. Stewart J. Imfinzi FDA approval history. Drugs.com. Updated August 19, 2024. Accessed November 27, 2024. 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This move marks perhaps one of the final health policy initiatives of Biden’s presidency. The new policies put forth in the plan would take effect in existing programs in 2026, expanding drug access to many who lack this coverage.","_key":"181a6f5eec21"},{"_type":"span","marks":["superscript"],"text":"1,2","_key":"40ea2329030c"}]},{"style":"normal","_key":"92d28b039c32","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"ba774a3cf4a70"}],"_type":"block"},{"_key":"6d55aa04f065","alignment":"right","asset":{"_type":"reference","_ref":"image-6d57708d4b82e1880c72625d8db04dde75570664-6720x4480-jpg"},"widthP":30,"disableTextWrap":false,"imgcaption":[{"children":[{"text":"The FDA has previously approved these antiobesity drugs for long-term use: liraglutide (Saxenda), orlistat (Xenical, Alli), bupropion-naltrexone (Contrave), phentermine-topiramate (Qsymia), semaglutide (Wegovy, Ozempic), and Tirzepatide (Zepbound, Mounjaro) | image credit: Sergej Gerasimov - stock.adobe.com","_key":"8feaecdcc0d6","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"795d23da6e49","markDefs":[]}],"_type":"figure","disableLightBox":true,"alt":"The FDA has previously approved these weight loss drugs for long-term use: liraglutide (Saxenda), orlistat (Xenical, Alli), bupropion-naltrexone (Contrave), phentermine-topiramate (Qsymia), semaglutide (Wegovy, Ozempic) and Tirzepatide (Zepbound, Mounjaro) | image credit: Sergej Gerasimov - stock.adobe.come"},{"children":[{"_type":"span","marks":[],"text":"“Increases in the prevalence of obesity in the United States and changes in the prevailing medical consensus towards recognizing obesity as a disease since the beginning of the Part D program in 2006 have compelled CMS to re-evaluate Part D coverage of anti-obesity medications (AOMs) for Medicare Part D enrollees with obesity,” the proposal writes, highlighting circumstances “where the drug’s prescribed use is not for a medically accepted indication (MAI) that is currently covered under Part D.” If made official, pending an endorsement from the Trump administration, their reevaluation would carry important implications for Part D beneficiaries.","_key":"018b7fae5fd80"}],"_type":"block","style":"normal","_key":"d6807ac35422","markDefs":[]},{"style":"normal","_key":"115aeb272a94","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"bbf68c2acd4c0"}],"_type":"block"},{"_key":"c8221c1fa3f1","markDefs":[],"children":[{"_type":"span","marks":[],"text":"AOMs have demonstrated great safety and efficacy throughout numerous randomized controlled trials (RCTs) over the years, as indicated by a 2021 literature review.","_key":"9fbd3296f2c00"},{"_type":"span","marks":["superscript"],"text":"3","_key":"c90844901615"},{"_type":"span","marks":[],"text":" This analysis surveyed 35 RCTs featuring robust data on 5 AOMs FDA-approved for long-term use: liraglutide (Saxenda), orlistat (Xenical, Alli), bupropion-naltrexone (Contrave), phentermine-topiramate (Qsymia), and semaglutide (Wegovy). Liraglutide and semaglutide in particular are members of the glucagon-like peptide 1 (GLP-1) receptor agonist class that has revolutionized obesity management in recent years. Despite their well-documented impact on weight loss and minimal rates of serious adverse events, decades-old legislation has prevented Medicare Part D’s coverage from extending to “weight loss” drugs, no matter that the medications are intended to treat the disease of obesity.","_key":"b3753a4501e1"},{"_type":"span","marks":["superscript"],"text":"1","_key":"ecf6f6127b1e"}],"_type":"block","style":"normal"},{"_type":"block","style":"normal","_key":"e441c246535d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"a0b429f7d5360"}]},{"children":[{"_type":"span","marks":[],"text":"The new proposal aims to reinterpret this ruling to allow plan coverage of AOMs when their purpose is to address a patient’s obesity and long-term weight management to hopefully prevent associated complications, comorbidities, and conditions. Notably, this reinterpretation would apply to Medicaid plans as well.","_key":"d3be319e6db80"},{"_key":"a0f198298fd2","_type":"span","marks":["superscript"],"text":"2"}],"_type":"block","style":"normal","_key":"bcc75e0ea1be","markDefs":[]},{"style":"normal","_key":"7bc3c3e48abc","markDefs":[],"children":[{"text":"","_key":"ec35edca9acd0","_type":"span","marks":[]}],"_type":"block"},{"children":[{"_type":"span","marks":[],"text":"If the Trump administration supports the proposal, CMS anticipates an additional 3.4 million patients who use Medicare—and 4 million who use Medicaid—could qualify for obesity medications.","_key":"054eb31e8e390"},{"_type":"span","marks":["superscript"],"text":"1","_key":"bf5f27a3e808"},{"_key":"03290025e891","_type":"span","marks":[],"text":" Earlier this year, a survey from "},{"text":"KFF","_key":"054eb31e8e391","_type":"span","marks":["3dd074ae926f"]},{"text":" indicated that over 60% of Americans are in favor of Medicare covering GLP-1 agonist medications","_key":"054eb31e8e392","_type":"span","marks":[]},{"_type":"span","marks":["superscript"],"text":"4","_key":"a310a4f4f587"},{"_type":"span","marks":[],"text":"; however, despite their popularity and growing evidence suggesting the benefits of these drugs for obesity-related conditions (including high blood pressure, sleep apnea, and fatty liver disease, among others), this would be a costly move. This coverage could rack up $25 billion in Medicare spending and $11 billion in Medicaid, with the federal government footing that bill. Cost considerations will weigh heavily on the incoming administration, especially considering CMS estimates that total Medicare spending will exceed $2 trillion in the next decade.","_key":"66486c85d347"},{"_key":"d669453015e1","_type":"span","marks":["superscript"],"text":"1"}],"_type":"block","style":"normal","_key":"4f705457b23f","markDefs":[{"_type":"link","href":"https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs/","_key":"3dd074ae926f","nofollow":true,"blank":true}]},{"_type":"block","style":"normal","_key":"253e7f13c04d","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"cf61085e42ab0"}]},{"style":"normal","_key":"ae3e4b65dcce","markDefs":[],"children":[{"_type":"span","marks":[],"text":"The proposal is expected to be published in the ","_key":"6fd0938be55a"},{"text":"Federal Register","_key":"eadbc3d82176","_type":"span","marks":["em"]},{"_type":"span","marks":[],"text":" on December 10. ","_key":"0ef86a6af5ee"}],"_type":"block"},{"markDefs":[],"children":[{"text":"","_key":"7aed633a4f77","_type":"span","marks":[]}],"_type":"block","style":"normal","_key":"33c0cf32097e"},{"children":[{"text":"References","_key":"908ac260da0f0","_type":"span","marks":["strong"]}],"_type":"block","style":"normal","_key":"4415e7d22092","markDefs":[]},{"children":[{"text":"1. Sanger-Katz M. Obesity drugs would be covered by Medicare and Medicaid under Biden proposal. ","_key":"ae8cf1dad9660","_type":"span","marks":[]},{"_type":"span","marks":["em"],"text":"New York Times. ","_key":"ae8cf1dad9661"},{"_key":"ae8cf1dad9662","_type":"span","marks":[],"text":"November 26, 2024. Accessed November 26, 2024. "},{"_type":"span","marks":["bbf16e8ced74"],"text":"https://www.nytimes.com/2024/11/26/upshot/obesity-drugs-medicare-medicaid.html","_key":"e32768b83008"}],"_type":"block","style":"normal","_key":"989da09b1b87","markDefs":[{"_type":"link","href":"https://www.nytimes.com/2024/11/26/upshot/obesity-drugs-medicare-medicaid.html","_key":"bbf16e8ced74","nofollow":true,"blank":true}]},{"children":[{"text":"2. Medicare and Medicaid Programs: Contract Year 2026 Policy and Technical Changes to the Medicare Advantage Program, Medicare Prescription Drug Benefit Program, Medicare Cost Plan Program, and Programs of All-Inclusive Care for the Elderly. ","_key":"ad4b374e52ef","_type":"span","marks":[]},{"_key":"6d0320ab3cf4","_type":"span","marks":["em"],"text":"Federal Register"},{"_type":"span","marks":[],"text":". Accessed November 26, 2024. https://www.federalregister.gov/public-inspection/2024-27939/medicare-and-medicaid-programs-contract-year-2026-policy-and-technical-changes-to-the-medicare","_key":"664e07dd516a"}],"_type":"block","style":"normal","_key":"4d85695462a4","markDefs":[]},{"markDefs":[],"children":[{"_type":"span","marks":[],"text":"3. Ahmad NN, Robinson S, Kennedy-Martin T, Poon JL, Kan H. Clinical outcomes associated with anti-obesity medications in real-world practice: a systematic literature review. ","_key":"3281cf8c1909"},{"_type":"span","marks":["em"],"text":"Obes Rev","_key":"53e3517b9e561"},{"_type":"span","marks":[],"text":". 2021;22(11):e13326. doi:10.1111/obr.13326","_key":"53e3517b9e562"}],"_type":"block","style":"normal","_key":"e53125d8e311"},{"style":"normal","_key":"095a182857ff","markDefs":[{"href":"https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs/","_key":"0da77b3db3e3","nofollow":true,"blank":true,"_type":"link"}],"children":[{"_key":"86723c85c7fa","_type":"span","marks":[],"text":"4. Montero A, Sparks G, Presiado M, Hamel L. KFF Health Tracking Poll May 2024: the public’s use and views of GLP-1 drugs. KFF. May 10, 2024. Accessed November 26, 2024. "},{"_type":"span","marks":["0da77b3db3e3"],"text":"https://www.kff.org/health-costs/poll-finding/kff-health-tracking-poll-may-2024-the-publics-use-and-views-of-glp-1-drugs/","_key":"c4cac695563b"}],"_type":"block"},{"_type":"block","style":"normal","_key":"1fdc0bda085b","markDefs":[],"children":[{"_type":"span","marks":[],"text":"","_key":"f4bead5178280"}]}],"authors":[{"displayName":"Kyle Munz","url":"kyle-munz"}],"_type":"article","drugMentions":"{\n \"drug_mentions\": [\"liraglutide (Saxenda)\", \"orlistat (Xenical, Alli)\", \"bupropion-naltrexone (Contrave)\", \"phentermine-topiramate (Qsymia)\", \"semaglutide (Wegovy)\"]\n}","documentGroupMapping":null,"audioUrl":"https://s3.us-east-1.amazonaws.com/ai-generated-audios/www.ajmc.com/1fc28fec-ef0c-4856-b96d-21e2d0a403ed_1732654770741.614235dd-4d19-41c7-9233-762f3d6212e2.mp3","documentGroup":null,"gptTakeaways":"• The proposal aims to expand Medicare and Medicaid coverage to include anti-obesity medications, recognizing obesity as a disease.\n\n• Anti-obesity medications have demonstrated safety and efficacy, but current legislation restricts Medicare Part D coverage.\n\n• If approved, the proposal could benefit millions of patients but would significantly increase Medicare and Medicaid spending.\n\n• The financial impact of the proposal is substantial, with projected costs of $25 billion for Medicare and $11 billion for Medicaid.","title":"New Proposal Aims to Expand Medicaid and Medicare Coverage for Obesity Drugs","targeting":{"content_placement":["news","topic/policy","stakeholders/providers","topic/healthcare-delivery","compendium/obesity"],"document_url":["new-proposal-aims-to-expand-medicaid-and-medicare-coverage-for-obesity-drugs"],"document_group":null,"rootDocumentGroup":[],"issue_url":"","publication_url":""},"relatedArticles":[{"title":"Venetoclax May Be an Option for Children With R/R AML, MDS ","url":{"current":"venetoclax-may-be-an-option-for-children-with-r-r-aml-mds","_type":"slug"},"thumbnail":{"alt":"MDS wooden blocks held by hand in glove | Image Credit: © Sviatlana - 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","_type":"article","_rev":"PlC7YDkXkx05WZqKmTlNOl","title":"FDA Approves Imatinib Oral Solution for Treatment of Various Cancers","_id":"05dfb464-9571-437f-ac3d-e916424c3e8d","_createdAt":"2024-11-26T17:08:39Z","authorMapping":[{"lastName":"Munz","_createdAt":"2023-07-19T18:48:50Z","_type":"author","_id":"30e9dc45-7c46-468b-b88c-40fcb46b4537","_updatedAt":"2024-05-20T19:25:58Z","url":{"_type":"slug","current":"kyle-munz"},"firstName":"Kyle","displayName":"Kyle Munz","_rev":"m9zO7fOEUWAduYt5irO25q","profileImage":{"_type":"mainImage","alt":"Kyle Munz","asset":{"_ref":"image-afb5da0a933e7f6f632d76cd52a5bc1c1243fb36-430x430-png","_type":"reference"}}}],"gptSummary":"The FDA has approved imatinib (Imkeldi), the first oral liquid tyrosine kinase inhibitor for treating various cancers, including GIST, MDS, MPD, CML, and Ph+ ALL. This approval offers a more accessible treatment option, especially for patients with swallowing difficulties or requiring tailored dosing. 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Safety and efficacy in pediatric Ph+ ALL populations remain unestablished.","thumbnail":{"_type":"mainImage","alt":"FDA Approval | image credit: gomixer - stock.adobe.com","caption":"FDA Approval | image credit: gomixer - stock.adobe.com","asset":{"_type":"reference","_ref":"image-f1f12e9d502c73f75e8062c6dd726c422c8aff78-4320x3473-jpg"}},"is_visible":true,"published":"2024-11-26T17:56:00.855Z","factCheckAuthorMapping":null,"contentCategory":{"_updatedAt":"2023-09-29T14:32:27Z","_createdAt":"2020-04-03T20:03:53Z","_rev":"Q2ZL7ihdIB33NiMMcGccmh","_type":"contentCategory","name":"Articles","_id":"3f4b3ced-7c9d-4fc4-967f-fe993087cce2"},"_updatedAt":"2024-11-26T17:56:17Z","documentGroupMapping":null,"ExcludeFromPubMedXML":false,"articleType":"News","body":[{"_key":"df4ee21b6f26","markDefs":[{"nofollow":false,"blank":true,"_type":"link","href":"https://www.ajmc.com/compendium/all","_key":"13865b6b5eee"},{"href":"https://www.ajmc.com/compendium/cll","_key":"7e8da0eda924","nofollow":false,"blank":true,"_type":"link"},{"_type":"link","href":"https://www.ajmc.com/compendium/myelodysplastic-syndromes","_key":"2945218f036a","nofollow":false,"blank":true}],"children":[{"_type":"span","marks":[],"text":"Yesterday, Marks Shorla Oncology’s announced the FDA’s approval of imatinib (Imkeldi). 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