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Impact on: dementia | IHI Innovative Health Initiative
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</form> </section> </div> </div> </div> </div> </nav> <div class="breadcrumb"> <div class="container"> <div> <div id="block-itheme-breadcrumbs"> <nav aria-label="breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol class="breadcrumb"> <li class="breadcrumb-item"> <a href="/">Home</a> </li> <li class="breadcrumb-item"> <a href="/projects-results">Projects and Results</a> </li> <li class="breadcrumb-item"> <a href="/projects-results/health-spotlights">Health Spotlights</a> </li> <li class="breadcrumb-item"> Impact On: Dementia </li> </ol> </nav> </div> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> </div> </header> <main role="main" id="my-content" class="impact-page"> <a id="main-content" tabindex="-1" aria-hidden="true"></a> <div class="hero-section bg-light"> <div class="hero-container container"> <div class="hero-wrapper row"> <div class="hero-content-wrapper col-12 col-md-7"> <div> <div id="block-itheme-page-title"> <div class="hero-content"> <h1 class="hero-title"> <span>Impact on: dementia</span> </h1> <p class="hero-body font-lg">Dementia affects millions of people in Europe and the number is continually rising. </p> </div> </div> </div> </div> <div class="hero-graphic-wrapper col-12 col-md-5 d-flex align-items-top justify-content-end p-0"> <div class="hero-graphic-svg-element" style="background: url('/themes/custom/itheme/images/graphic-elements/graphic-elements-08.svg') no-repeat 50% 25px;background-size:auto 85%;"></div> </div> </div> </div> </div> <div class="layout-content"> <div class="container"> <div> <div id="block-itheme-content"> <article data-history-node-id="12064" class="impact-page full clearfix"> <div class="content"> <div class="row mb-6"> <div class="col-12 col-lg-7 col-xl-8"> <div><div class="row"> <div class="col-12"> <p> </p> </div> </div> <div class="row" data-n1ed-block-id="19778"> <div class="col-12"> <h3 class="title-yellow font-xxl mb-5">What's the problem?</h3> <p style="margin-bottom:11px">Dementia is amongst the top ten causes of death<a> </a>and more than 55 million people have dementia worldwide. <a>In Europe, the number of deaths related to dementia rises every year, with more than 250 000 deaths in 2020</a>. The societal burden of neurodegenerative diseases is heavy, impacting patients, their families and public healthcare systems over decades. There is no cure, and treatments for symptoms may only work for some people, usually for a short period. Patients with dementia often have co-morbidities which give rise to complexities in terms of therapeutic care. Clinical trials tend to have a high failure rate, especially at the late stages, there is a lack of understanding of the underlying disease mechanisms, and translating laboratory findings into new treatments has proven difficult.</p> <p> </p> <div class="col-12"> <h3 class="title-yellow font-xxl mb-5">What are we doing about it?</h3> <p style="margin-bottom:11px">The Innovative Health Initiative (IHI)’s first call for proposals sought the development of a decision-support system to support a more holistic approach to treating patients with neurodegenerative diseases. The Innovative Medicines Initiative (<a>IMI) has funded over 20 projects in this area, accounting for around 10% of the budget.</a> Most of the IMI projects also focus on Alzheimer’s disease, the most prevalent cause of dementia, but we also have projects that deal with other dementia-causing conditions such as Parkinson’s and Huntington’s disease.</p> <p style="margin-bottom:11px">The projects cover the whole spectrum of medical research and drug development, and patients play an active role in many projects, bringing their experience of their disease to the table.</p> <p style="margin-bottom:11px">Given the complexity of the brain and nervous system, it is unsurprising that many of our projects are unravelling the role of specific genes and proteins in disease. Other projects are exploring ways of identifying people at greatest risk of developing dementia and on how to improve diagnosis, management and development of novel treatments. We also have projects applying a ‘big data’ approach to progress in the area as well as investigations into personalised approaches to managing neurodegeneration.</p> <p> </p> </div> </div> </div> <div class="row" data-n1ed-block-id="19778"> <div class="col-12"> <h3 class="title-yellow font-xxl mb-5">IHI / IMI research is...</h3> <table class="table" style="width:100%;table-layout: fixed;"> <tbody> <tr> <td><strong><em>...translating scientific findings into new treatments</em></strong></td> <td> <p><a href="https://www.imi.europa.eu/projects-results/project-factsheets/adapted" target="_blank">ADAPTED</a>, <a href="https://www.imi.europa.eu/projects-results/project-factsheets/imprind" target="_blank">IMPRIND</a> and <a href="https://www.imi.europa.eu/projects-results/project-factsheets/phago" target="_blank">PHAGO</a> have made important discoveries about the function of the APOE gene, the key mechanisms involved in tau protein misfolding and neuroinflammation, translating their findings into new tools, assays and platforms. <a href="https://www.imi.europa.eu/projects-results/project-factsheets/eqipd" target="_blank">EQIPD</a> developed a wiki-based quality system to help increase adherence to rigorous, evidence-based practices in preclinical research helping to cut down on the high failure rate in trials of potential dementia drugs.</p> </td> </tr> <tr> <td><strong><em>…categorising dementia into different subtypes</em></strong></td> <td> <p><a href="https://www.imi.europa.eu/projects-results/project-factsheets/aetionomy" target="_blank">AETIONOMY</a>, <a href="https://www.imi.europa.eu/projects-results/project-factsheets/emif" target="_blank">EMIF-AD</a> and <a href="/" style>PRISM </a>identified groups of patients with the same neurodegenerative disease but who differ significantly from each other, taking us closer to personalised treatments.</p> </td> </tr> <tr> <td><strong><em>…reducing the high failure rate of clinical trials of dementia drugs</em></strong></td> <td>Biomarkers identified by EMIF-AD have improved patient selection for trials, as have social functioning clues from personal devices (PRISM). <a href="https://www.imi.europa.eu/projects-results/project-factsheets/radar-ad" target="_blank">RADAR-AD</a>'s digital platform can track changes in cognitive and functional abilities and <a href="http://ep-ad.org/" target="_blank">EPAD</a>'s platform makes enrolment in clinical trials more efficient. <a href="https://amypad.eu/" target="_blank">AMYPAD</a>'s platform is studying the optimal use of β-amyloid PET imaging for more better and cheaper trials, and <a href="https://www.imi.europa.eu/projects-results/project-factsheets/aetionomy" target="_blank">AETIONOMY</a> created ‘Virtual Patient Cohorts’.</td> </tr> <tr> <td><strong><em>…generating invaluable resources and infrastructure to feed future research</em></strong></td> <td><a href="http://ep-ad.org/2021/03/18/the-final-epad-dataset-is-now-available-on-the-alzheimers-disease-workbench" target="_blank">EPAD</a>, <a href="https://www.imi.europa.eu/projects-results/project-factsheets/aetionomy" target="_blank">AETIONOMY</a> and <a href="https://www.imi-adapted.eu/single-post/2020/09/29/cells-data-and-publications-the-legacy-of-adapted" target="_blank">ADAPTED</a> generated invaluable datasets and biobanks for Alzheimer’s research. . <a href="https://ebisc.org/" target="_blank">EBiSC2</a> has made more than 900 human-inducible pluripotent stem cells (hiPSC) available, including many from people with dementia. <a href="http://ep-ad.org/for-research-participants/why-participate-in-epad/trial-locations/" target="_blank">EPAD's Trial Delivery Centres</a> is a connected and certified network of sites that are qualified to run Alzheimer’s clinical trials. <a href="https://www.imi.europa.eu/projects-results/project-factsheets/roadmap" target="_blank">ROADMAP</a> created an interactive data visualisation tool that synthesises data sources from around Europe, while the <a href="http://ep-ad.org/epad-academy/" target="_blank">EPAD Academy</a> and <a href="https://quality-preclinical-data.eu/learning-environment/eqipd-e-learning-modules/" target="_blank">EQIPD training</a> modules trained a new generation of researchers, and the Decision Tool from <a href="https://www.imi-neuronet.org/regulatory-hta-decision-tool/" target="_blank">NEURONET</a> helps researchers engage with regulatory and HTA bodies.</td> </tr> <tr> <td><b><i>…leveraging big data and AI to deliver personalised approaches to diagnosis</i></b></td> <td>The IHI <a href="https://www.ihi.europa.eu/projects-results/project-factsheets/prominent">PROMINENT</a> project will draw on existing AI tools to develop a digital platform that will improve the diagnosis and personalised treatment of Alzheimer’s disease. <a href="https://www.imi.europa.eu/projects-results/project-factsheets/aetionomy" target="_blank">AETIONOMY</a><u> </u>developed computer simulations that will help us to better understand how a brain slides into dementia. The IHI <a href="https://www.ihi.europa.eu/projects-results/project-factsheets/predictom">PREDICT-OM</a> project is developing a new way of screening people for dementia using digital technologies and algorithms based on AI that can be started from the comfort of a patient's own home.</td> </tr> </tbody> </table> </div> </div></div> <div class="related-nodes mt-5"> <div class="related-nodes-title">Related projects</div> <div class="related-nodes-wrapper"> <div> <div> <article data-history-node-id="4786" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/adapted" class="related-nodes-link"> <span>ADAPTED</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Alzheimer's disease apolipoprotein pathology for treatment elucidation and development</div> </p> </div> </article> </div> <div> <article data-history-node-id="6986" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/imprind" class="related-nodes-link"> <span>IMPRiND</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Inhibiting misfolded protein propagation in neurodegenerative diseases</div> </p> </div> </article> </div> <div> <article data-history-node-id="4796" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/phago" class="related-nodes-link"> <span>PHAGO</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Inflammation and AD: modulating microglia function - focussing on TREM2 and CD33</div> </p> </div> </article> </div> <div> <article data-history-node-id="4621" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/aetionomy" class="related-nodes-link"> <span>AETIONOMY</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=1">IMI1</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Organising mechanistic knowledge about neurodegenerative diseases for the improvement of drug development and therapy</div> </p> </div> </article> </div> <div> <article data-history-node-id="4556" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/emif" class="related-nodes-link"> <span>EMIF</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=1">IMI1</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>European Medical Information Framework</div> </p> </div> </article> </div> <div> <article data-history-node-id="4751" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/prism" class="related-nodes-link"> <span>PRISM</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Psychiatric Ratings using Intermediate Stratified Markers: providing quantitative biological measures to facilitate the discovery and development of new treatments for social and cognitive deficits in AD, SZ, and MD</div> </p> </div> </article> </div> <div> <article data-history-node-id="8647" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/radar-ad" class="related-nodes-link"> <span>RADAR-AD</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Remote assessment of disease and relapse – Alzheimer’s disease</div> </p> </div> </article> </div> <div> <article data-history-node-id="4781" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/amypad" class="related-nodes-link"> <span>AMYPAD</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Amyloid imaging to prevent Alzheimer’s disease</div> </p> </div> </article> </div> <div> <article data-history-node-id="4806" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/roadmap" class="related-nodes-link"> <span>ROADMAP</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Real world outcomes across the AD spectrum for better care: multi-modal data access platform</div> </p> </div> </article> </div> <div> <article data-history-node-id="8670" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/neuronet" class="related-nodes-link"> <span>NEURONET</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=0">Closed</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Efficiently networking European neurodegeneration research</div> </p> </div> </article> </div> <div> <article data-history-node-id="12614" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/prominent" class="related-nodes-link"> <span>PROMINENT</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=1">Ongoing</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=3">IHI</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Precision medicine platform in neurodegenerative disease</div> </p> </div> </article> </div> <div> <article data-history-node-id="12103" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/epnd" class="related-nodes-link"> <span>EPND</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=1">Ongoing</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=2">IMI2</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>European Platform for Neurodegenerative Diseases </div> </p> </div> </article> </div> <div> <article data-history-node-id="12696" class="mb-5"> <div class="related-nodes-content"> <div class="related-nodes-body"> <a href="/projects-results/project-factsheets/predictom" class="related-nodes-link"> <span>PREDICTOM</span> </a> <div> <span class="badge badge-primary font-weight-bold"> <span class="project-status"><a href="/projects-results/project-factsheets?status=1">Ongoing</a></span> </span> <span class="badge badge-secondary font-weight-bold"> <span class="project-imi-programme"><a href="/projects-results/project-factsheets?type=3">IHI</a></span> </span> </div> </div> <p class="related-nodes-text"> <div>Prediction of Alzheimer’s disease using an AI driven screening platform</div> </p> </div> </article> </div> </div> </div> </div> </div> <div class="article-sidebar col-12 col-lg-5 col-xl-4"> <div class="row justify-content-md-end"> <div class="col-12 col-lg-11 col-xl-10 px-0 d-flex flex-column justify-content-center"> <div class="sidebars mx-auto"> <div class="mb-6"><div class="row" data-n1ed-block-category="gallery"> <div class="col-12 py-3 text-center"> <div class="embed-responsive embed-responsive-16by9"><iframe allowfullscreen="allowfullscreen" src="//youtube.com/embed/z4qJNQFnMAc?end=61" style="border:none" width="560px" height="315px"></iframe></div> <h1 class="mt-3">The inaccessible brain</h1> <p>IMI funded a project called Aetionomy that set out to come up with better ways to classify Alzheimer's and other neurodegenerative diseases. The academic lead of the project, Prof. Martin Hofmann-Apitius explains one of the major challenges with this kind of resrearch.</p> <div class="mt-3"><a class="btn btn-primary" href="https://www.youtube.com/watch?v=z4qJNQFnMAc" role="button" target="_blank">Watch</a></div> </div> </div> <script src="//cdn.n1ed.com/widgets.js?apiKey=R41BZ6PI"></script></div> <h2 class="sub-headings-simple">What's the problem?</h2><div class="mb-6"><div class="row" data-n1ed-block-category="gallery"> <div class="col-12 text-center py-3"> <h1>Achievements</h1> </div> </div> <div class="row" data-n1ed-block-id="170504"> <div class="col-12"> <div class="sidebar-card n1ed--fake-container" data-bootstrap-contains="rows"> <div class="sidebar-card-wrapper background-default row g-0"> <div class="sidebar-card-img-stretched-circle col-12"> <p><img alt="Digital brain by jijomathaidesigners via Shutterstock" data-n1ed-img-height="360" data-n1ed-img-width="360" src="/sites/default/files/flmngr/DocPatient_shutterstock_2173377947_fizkes.jpg"></p> </div> <div class="sidebar-card-main col-12"> <div class="sidebar-card-title text-secondary"><span style="box-sizing: border-box;">PROMINENT – a new IHI project with a focus on Alzheimer’s disease</span></div> <div class="sidebar-card-body">The project aims to set up a digital platform to improve the diagnosis and personalised treatment of people with Alzheimer’s plus other diseases. <a href="https://www.ihi.europa.eu/news-events/newsroom/prominent-new-ihi-project-focus-alzheimers-disease" target="_blank">More...</a></div> </div> </div> </div> </div> <div class="col-12"> <div class="sidebar-card n1ed--fake-container" data-bootstrap-contains="rows"> <div class="sidebar-card-wrapper background-default row g-0"> <div class="sidebar-card-img-stretched-circle col-12"> <p><img alt="Digital brain by jijomathaidesigners via Shutterstock" data-n1ed-img-height="360" data-n1ed-img-width="360" src="/sites/default/files/flmngr/DigitalBrain_shutterstock_1286139133_jijomathaidesigners.jpg"></p> </div> <div class="sidebar-card-main col-12"> <div class="sidebar-card-title text-secondary">IMI project opens up neurodegenerative disease research</div> <div class="sidebar-card-body">EPND's Cohort Catalogue will help to accelerate the hunt for biological markers of neurodegenerative diseases like Alzheimer's and Parkinson's diseases. <a href="https://www.ihi.europa.eu/news-events/newsroom/imi-project-opens-neurodegenerative-disease-research" target="_blank">More...</a></div> </div> </div> </div> </div> <div class="col-12"> <div class="sidebar-card n1ed--fake-container" data-bootstrap-contains="rows"> <div class="sidebar-card-wrapper background-default row g-0"> <div class="sidebar-card-img-stretched-circle col-12"> <p><img alt="Man with coffee and laptop. Image by Lisa Fotios via Pexels." data-n1ed-img-height="360" data-n1ed-img-width="360" src="/sites/default/files/flmngr/ManLaptop_Pexels_LisaFotios-3197389.jpg"></p> </div> <div class="sidebar-card-main col-12"> <div class="sidebar-card-title text-secondary"><span style="box-sizing: border-box;">IMI Alzheimer’s projects issue guidance on giving biomarker info to research participants</span></div> <div class="sidebar-card-body">The guidance influenced the work of IMI project EPAD, which used biomarker tests to collect data on the early stages of Alzheimer's disease. <a href="https://www.ihi.europa.eu/news-events/newsroom/imi-alzheimers-projects-issue-guidance-giving-biomarker-info-research">More...</a></div> </div> </div> </div> </div> <div class="col-12"> <div class="sidebar-card n1ed--fake-container" data-bootstrap-contains="rows"> <div class="sidebar-card-wrapper background-default row g-0"> <div class="sidebar-card-img-stretched-circle col-12"> <p><img alt="Genomics. Image by pikepicture via Shutterstock" data-n1ed-img-height="360" data-n1ed-img-width="360" src="/sites/default/files/flmngr/Genomics_shutterstock_1414483640_pikepicture.jpg"></p> </div> <div class="sidebar-card-main col-12"> <div class="sidebar-card-title text-secondary"><span style="box-sizing: border-box;"><span style="box-sizing: border-box;">EPAD releases additional data to Alzheimer’s research community</span></span></div> <div class="sidebar-card-body">IMI project EPAD has made genomic data from its study of the earliest stages of Alzheimer’s disease available to the wider research community. <a href="https://www.ihi.europa.eu/news-events/newsroom/epad-releases-additional-data-alzheimers-research-community">More...</a></div> </div> </div> </div> </div> </div> <script src="//cdn.n1ed.com/widgets.js?apiKey=R41BZ6PI"></script></div> <div class="mb-6"><div class="row"> <div class="col-12"> </div> </div> <div class="row" data-n1ed-be-quick-action-highlight="block" data-n1ed-block-id="123631"> <div class="col-12"> <div class="cta-card-icon n1ed--fake-container" data-bootstrap-contains="rows"> <div class="row"> <div class="col-12"> <div class="cta-title-wrapper"> <div class="cta-icon"><span class="icon icon-lg icon-search"> </span></div> <div class="cta-title">Event: IMI impact on dementia</div> </div> </div> </div> <div class="cta-details row g-0"> <div class="cta-body col-12 col-md-8 pe-2"> <div>IMI hosted a series of events highlighting the impact on different research areas</div> </div> <div class="cta-main-link col-12 col-md-4"><a class="btn btn-primary" href="/news-events/events/imi-impact-dementia-event" role="button" target="_blank">Watch<span class="icon-white icon-arrow-right"> </span></a></div> </div> </div> </div> </div> <script src="//cdn.n1ed.com/widgets.js?apiKey=R41BZ6PI"></script></div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </div> </div> </main> <footer class="mt-auto footer-class" id="my-footer"> <div> <div id="block-newsletteraction"> <div><div class="container"> <div class="row"> <div class="col-12"> <hr></div> </div> <div class="row py-6"> <div class="col-12 col-lg-3 h-100 mb-4 mb-lg-0"> <div class="font-xxl">Newsletter</div> </div> <div class="col-12 col-lg-6 h-100 font-lg text-muted mb-4 mb-lg-0">Our monthly newsletter provides announcements on IHI events, calls for proposals and news from our projects. 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