Search results for: microvesicles

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microvesicles</title> <meta name="description" content="Search results for: microvesicles"> <meta name="keywords" content="microvesicles"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="microvesicles"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: microvesicles</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Biophysical Features of Glioma-Derived Extracellular Vesicles as Potential Diagnostic Markers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abhimanyu%20Thakur">Abhimanyu Thakur</a>, <a href="https://publications.waset.org/abstracts/search?q=Youngjin%20Lee"> Youngjin Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Glioma is a lethal brain cancer whose early diagnosis and prognosis are limited due to the dearth of a suitable technique for its early detection. Current approaches, including magnetic resonance imaging (MRI), computed tomography (CT), and invasive biopsy for the diagnosis of this lethal disease, hold several limitations, demanding an alternative method. Recently, extracellular vesicles (EVs) have been used in numerous biomarker studies, majorly exosomes and microvesicles (MVs), which are found in most of the cells and biofluids, including blood, cerebrospinal fluid (CSF), and urine. Remarkably, glioma cells (GMs) release a high number of EVs, which are found to cross the blood-brain-barrier (BBB) and impersonate the constituents of parent GMs including protein, and lncRNA; however, biophysical properties of EVs have not been explored yet as a biomarker for glioma. We isolated EVs from cell culture conditioned medium of GMs and regular primary culture, blood, and urine of wild-type (WT)- and glioma mouse models, and characterized by nano tracking analyzer, transmission electron microscopy, immunogold-EM, and differential light scanning. Next, we measured the biophysical parameters of GMs-EVs by using atomic force microscopy. Further, the functional constituents of EVs were examined by FTIR and Raman spectroscopy. Exosomes and MVs-derived from GMs, blood, and urine showed distinction biophysical parameters (roughness, adhesion force, and stiffness) and different from that of regular primary glial cells, WT-blood, and -urine, which can be attributed to the characteristic functional constituents. Therefore, biophysical features can be potential diagnostic biomarkers for glioma. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=glioma" title="glioma">glioma</a>, <a href="https://publications.waset.org/abstracts/search?q=extracellular%20vesicles" title=" extracellular vesicles"> extracellular vesicles</a>, <a href="https://publications.waset.org/abstracts/search?q=exosomes" title=" exosomes"> exosomes</a>, <a href="https://publications.waset.org/abstracts/search?q=microvesicles" title=" microvesicles"> microvesicles</a>, <a href="https://publications.waset.org/abstracts/search?q=biophysical%20properties" title=" biophysical properties"> biophysical properties</a> </p> <a href="https://publications.waset.org/abstracts/131887/biophysical-features-of-glioma-derived-extracellular-vesicles-as-potential-diagnostic-markers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/131887.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Microvesicles in Peripheral and Uterine Blood in Women with Atypical Hyperplasia and Endometrioid Endometrial Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Barbara%20Zapala">Barbara Zapala</a>, <a href="https://publications.waset.org/abstracts/search?q=Marek%20Dziechciowski"> Marek Dziechciowski</a>, <a href="https://publications.waset.org/abstracts/search?q=Olaf%20Chmura"> Olaf Chmura</a>, <a href="https://publications.waset.org/abstracts/search?q=Monika%20Piwowar"> Monika Piwowar</a>, <a href="https://publications.waset.org/abstracts/search?q=Katarzyna%20Gawlik"> Katarzyna Gawlik</a>, <a href="https://publications.waset.org/abstracts/search?q=Dorota%20Pawlicka-Gosiewska"> Dorota Pawlicka-Gosiewska</a>, <a href="https://publications.waset.org/abstracts/search?q=Krzysztof%20Skotniczny"> Krzysztof Skotniczny</a>, <a href="https://publications.waset.org/abstracts/search?q=Bogdan%20Solnica"> Bogdan Solnica</a>, <a href="https://publications.waset.org/abstracts/search?q=Kazimierz%20Pitynski"> Kazimierz Pitynski</a> </p> <p class="card-text"><strong>Abstract:</strong></p> BACKGROUND: Endometrial cancer is one of the most common gynecologic malignancy in developed countries.We hypothesized that amount of circulating micro-particles in blood may be connected with the development of endometrial hyperplasia and endometrial cancer. The aim of this study was to measure the micro-particles amount in uterine venous blood and in peripheral venous blood in women with atypical endometrial hyperplasia and endometrioid endometrial cancer. MATERIALS AND METHODS: By using flow cytometry (BD Canto II cytometer) we measured micro-particles amount in citrate plasma samples from peripheral and uterine venous blood of women with atypical hyperplasia of endometrium or endometrial cancer. We determined the amount of total (TF+), endothelial (CD144+) and monocytic (CD14+) micro- particles. RESULTS: Here we show statistically significant higher micro-particle levels in women with atypical hyperplasia of endometrium or endometrial cancer in comparison to healthy women. Performing measurements of the amounts of total, endothelial and monocytic microparticles allow for reliable differentiation between healthy, atypical hyperplasia and endometrial cancer groups. In blood samples from uterine veins the circulating micro-particle levels were significantly different from peripheral blood samples. The micro-particle levels in uterine blood samples were 7-fold higher than in those from peripheral blood of women with both atypical hyperplasia of endometrium and endometrial cancer when compared to the control group of healthy women. CONCLUSION: These results strongly suggested that the level of circulating micro-particles may be a sign of endometrial cancer development, however the detailed study is needed focusing on molecular processes passed through this small circulating molecules. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometrial%20cancer" title="endometrial cancer">endometrial cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=endometrial%20hyperplasia" title=" endometrial hyperplasia"> endometrial hyperplasia</a>, <a href="https://publications.waset.org/abstracts/search?q=microvesicles" title=" microvesicles"> microvesicles</a>, <a href="https://publications.waset.org/abstracts/search?q=uterine%20blood" title=" uterine blood"> uterine blood</a> </p> <a href="https://publications.waset.org/abstracts/123909/microvesicles-in-peripheral-and-uterine-blood-in-women-with-atypical-hyperplasia-and-endometrioid-endometrial-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/123909.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">134</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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Search results for: microvesicles