Evolutionary Genetics

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src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/logo_genetic.jpg" alt="logo genetics" width="140" height="79"></td> </tr> <tr> <td height="2" width="140"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/white.gif" alt="" width="140" height="2"></td> </tr> </table></td> <td width="620" valign="top"><table width="620" border="0" cellspacing="0" cellpadding="0"> <tr> <td rowspan="3" width="2"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/transparent.gif" width="2" height="1" alt=""></td> <td><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/hintergrund01.jpg" alt="banner" width="618" height="30"></td> </tr> <tr> <td height="81"><table width="100%" border="0" cellspacing="0" cellpadding="3"> <tr> <td width="25%"><div align="center"><a href="team_paabo.html" class="metanavi">Evolutionary<br> Genetics<br> (Svante Pääbo,<br> Department Director) </a></div> </td> <td width="25%"><div align="center"><a href="team_moerl.html" class="metanavi">Biochemnistry of<br> RNA/Protein Interactions<br> (Mario Mörl) </a></div> </td> <td width="25%"><div align="center"><a href="team_stoneking.html" class="metanavi">Molecular <br> Anthropology<br> (Mark <br> Stoneking)</a> </div> </td> <td width="25%"><div align="center"><a href="team_lachmann.html" class="metanavi">Theoretical <br> Biology<br> (Michael <br> Lachmann) </a></div> </td> </tr> </table></td> </tr> <tr> <td valign="bottom"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/linie01.gif" width="618" height="1"></td> </tr> </table></td>  </tr> <tr bgcolor="#FFFFFF">  <td width="140" height="300" valign="top" bgcolor="#999999"><table width="140" border="0" cellspacing="0" cellpadding="0" bgcolor="#404687"> <tr> <td width="10" height="2" valign="top"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/white140pix.gif" width="140" height="2" alt=""></td> </tr> <tr> <td bgcolor="#404687" id="home" 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onmouseover="SpaltenFaerben('#C225d7','facility')" onmouseout="SpaltenFaerben('#404687','facility')" id="facility" onfocus="this.blur()" class="hauptnavi">The Laboratory Facilities at the <br>Max Planck Institute</a></div></td> </tr> <tr> <td height="2"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/white140pix.gif" width="140" height="2" alt=""></td> </tr> <tr> <td bgcolor="#404687" id="lab" height="30" valign="middle"><div align="center"><a href="/web/20041224023747/http://www.eva.mpg.de/genetics/lab_meeting/labor.html" onmouseover="SpaltenFaerben('#C225d7','lab')" onmouseout="SpaltenFaerben('#404687','lab')" id="lab" onfocus="this.blur()" class="hauptnavi">Lab Meeting</a></div></td> </tr> <tr> <td height="2"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/white140pix.gif" width="140" height="2" alt=""></td> </tr> <tr> <td bgcolor="#404687" id="imp" height="30" valign="middle"><div align="center"><a href="https://web.archive.org/web/20041224023747/http://www.eva.mpg.de/english/kontakt.htm" onmouseover="SpaltenFaerben('#C225d7','imp')" onmouseout="SpaltenFaerben('#404687','imp')" id="imp" onfocus="this.blur()" class="hauptnavi">Imprint</a></div></td> </tr> <tr> <td height="2"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/white140pix.gif" alt="" width="140" height="2"></td> </tr> </table></td> <td> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td> </td> <td> </td> <td> </td> </tr> <tr> <td width="3%" height="400"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/transparent.gif" alt="" width="20" height="1"></td> <td width="92%" valign="top"><table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td class="content"><span class="HeadGrey"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/svante.jpg" alt="svante paabo" width="96" height="128" border="0" align="right">Evolutionary Genetics (Svante Pääbo)</span><br><br> <br> Contact: Viola Mittag (mittag at eva.mpg.de), Tel: +49 (0) 341 35 50 500 <br> <br><br> Three major groups of projects are pursued in the group:<br>  </td> </tr> <tr> <td> <p align="justify"><b>Human great ape genetic history.</b></p> <p align="justify">By comparative DNA sequencing in humans, chimpanzees, gorillas and orangutans we try to gain a better understanding of the origin, time and early migrations of humans and their closest relatives. We also investigate patterns of SNPs in populations in Scandinavia and northern Eurasia in order to understand more recent human history and contribute to the development of strategies to map complex traits.</p> <p align="justify"><b>Ancient DNA.</b></p> <p align="justify">We develop methods for the retrieval of DNA sequences from archaeological and paleontological remains. In particular, we continuously try to improve the criteria necessary to support the authenticity of DNA sequences retrieved from ancient specimens.<br> We have shown that biochemical analyses are useful for gauging the preservation of macromolecules in ancient remains and that cross-links involving reducing sugars, oxidative damage and hydrolytic deamination are crucial forms of damage in ancient DNA. We have furthermore shown that chemical reagents that cleave sugar cross-links can make DNA from some ancient remains available for amplification.<br> We use these techniques to elucidate the history of humans and Pleistocene mammals. For example, we are studying DNA sequences from Neanderthals, cave bears and ground sloths. In particular, we focus on coprolites; using these we can study the DNA from both the individual and its diet.</p> <p align="justify"><b>Human-ape comparisons.</b></p> <p align="justify">We approach the genomic differences between humans and their closest relatives at several levels. For example, we perform low-coverage shot-gun sequencing of ape genomes in order to elucidate general patterns of DNA sequence evolution. We perform extensive EST-sequencing in order to identify genes under selection and improve our understanding of the forces that determine gene evolution in primates. We study gene expression patterns in various tissues in primates and other mammals in order to understand how the transcriptome evolves.</p> </td> </tr> <tr> <td><br> <br></td> </tr> <tr> <td><a href="staff_paabo.html"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/pfeil.gif" width="30" height="15" border="0" alt="link: group staff"></a><strong><a href="staff_paabo.html">Group staff</a></strong></td> </tr> <tr> <td> </td> </tr> <tr> <td><a href="public_paabo.html"><img src="/web/20041224023747im_/http://www.eva.mpg.de/genetics/images/pfeil.gif" width="30" height="15" border="0" alt="link: back"></a><strong><a href="public_paabo.html">Some recent papers from the Pääbo laboratory</a></strong></td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> <tr> <td> </td> </tr> </table></td> <td width="5%"> </td> </tr> </table></td>  </tr> </table> </td> <td width="2%"> </td> </tr> </table> </body> </html>

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Evolutionary Genetics