The Clinical Proteomic Technologies for Cancer

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href="javascript:window.print()"><i class="fa fa-print" aria-hidden="true"></i> PRINT</a></div> </div> <h1 id="page-title" class="title">TIMP Metallopeptidase Inhibitor 1 Peptide 1</h1> <hr /> </div> <div id="block-system-main" class="block block-system block-system-main" > <div class="content" id="detail_page_content"> <article id="node-27" class="node node-page view-mode-full" about="https://proteomics.cancer.gov/antibody-portal/available-antibodies/antibody-portal" typeof="foaf:Document"> <span property="dc:title" content="Antibody Portal" class="rdf-meta element-hidden"></span> <span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> </article>  <div id="search-fields-container_antibody-browse"> <a title="Expand all page details" href="javascript:void(0);" onclick="showAllAntigenDataBlock('open',1)">Expand All</a> - <a title="Collapse all page details" href="javascript:void(0);" onclick="showAllAntigenDataBlock('close',1)">Collapse All</a> </div> <div class="clear"></div> <div id="detail-menu"> <div class="detail-menu-title"><h2>Antibodies</h2></div> <ul> <li class="antibody-name"> <h3><a href="#CPTC-TIMP1-1">CPTC-TIMP1-1</a></h3>  <a class="manageMenuBlock-link" href="javascript:void(0)" id="top-antibody-1" onclick="manageMenuBlock(this.id); showDataBlock('antibody-1',false)">[hide details]</a> <div class="top_links" id="menu-top-antibody-1"> <ul class="sub-menu"> <li><a href="#CPTC-TIMP1-1-Background">Background</a>| <a href="#CPTC-TIMP1-1-Characterization">Characterization Data</a></li> </ul> </div> </li> </ul> <div class="detail-menu-title"><h2>Antigen</h2></div> <ul> <li class="antibody-name"><h3><a href="#TIMP_Metallopeptidase_Inhibitor_1_Peptide_1">TIMP Metallopeptidase Inhibitor 1 Peptide 1</a></h3> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" id="top-antigen" onclick="manageMenuBlock(this.id); showDataBlock('block-antigen')">[hide details]</a> <div class="top_links" id="menu-top-antigen"> <ul class="sub-menu"> <li><a href="#TIMP Metallopeptidase Inhibitor 1 Peptide 1-Background">Background</a>| <a href="#TIMP Metallopeptidase Inhibitor 1 Peptide 1-Characterization">Characterization Data</a>| <a href="#TIMP Metallopeptidase Inhibitor 1 Peptide 1-SOPs">SOPs</a>| <a href="#TIMP Metallopeptidase Inhibitor 1 Peptide 1-Links">Links</a></li> </ul> </div> </li> </ul> </div> <a name="CPTC-TIMP1-1"></a> <div class="well"> <div class="detail-type-header"> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" onclick="showDataBlock('antibody-1',true)"> <h4><i class="fa fa-minus icon-antibody-1" aria-hidden="true"></i>Antibody: CPTC-TIMP1-1</h4> </a> </div> <div id="antibody-menu-1" title="Click to display Antibody data" class="block_record_menu_down_icon" onclick="manageMenuBlock('top-antibody-1'); showDataBlock('antibody-1',false)"> </div> <div class="block_record" id="antibody-1"> <a name="CPTC-TIMP1-1-Background"></a> <h5 class="nopadding">Background</h5> <div class="detail-label"><p>Catalog Number:</p></div> <div class="detail-value"><p>CPTC-TIMP1-1</p></div> <div class="clear"></div> <div class="detail-label"><p>Target Antigen:</p></div> <div class="detail-value"><p>TIMP Metallopeptidase Inhibitor 1 Peptide 1</p></div> <div class="clear"></div> <div class="detail-label"><p>Isotype:</p></div> <div class="detail-value"><p>IgG</p></div> <div class="clear"></div> <div class="detail-label"><p>Species:</p></div> <div class="detail-value"><p>Rabbit Recombinant Cloned Antibody</p></div> <div class="clear"></div> <div class="detail-label"><p>Last Updated:</p></div> <div class="detail-value"><p>02/02/2024</p></div> <div class="clear"></div> <div class="detail-label"><p>Antigen Recognition(s):</p></div> <div class="detail-value"><p>Peptide</p></div> <div class="clear"></div> <h5>Purchase</h5> <ul class="url-list"> <a name="CPTC-TIMP1-1-Links"></a> <li class="cart"> <strong>DSHB</strong> <a href="../cart/Q1BUQy1USU1QMS0x"> CPTC-TIMP1-1 </a> </li> </ul> <a name="CPTC-TIMP1-1-Characterization"></a> <h5>Characterization Data <a title="Compare characterization data" class="show-for-medium-up" href="#" data-open="compareModal" onclick="showCompare(486);">[Compare Characterization Data]</a></h5> <div id="characterization_results_0"> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_1"> <h6><i class="fa fa-plus characterization_1" aria-hidden="true"></i>  IHC HPA</h6> </a> <div class="characterization_container" id="characterization_1"> Download <a href='/file/download/antibody_original/ef2ec50045522c73dfb1bef29c763257' title='Click to download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)'>This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</a> (366.6 KB) <h3 class="detail-type-header align-left">CPTC-TIMP1-1 Evaluation by the Human Protein Atlas</h3> <div><p>Result: <strong>Negative</strong></p></div> <p class="detail-type-text">This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Antibody Evaluation by Human Protein Atlas (62.6 KB)" href="/file/download/characterization_image_sop/2b9c44e43c5c9761c168c019666b3d8f">Antibody Evaluation by Human Protein Atlas (62.6 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_2"> <h6><i class="fa fa-plus characterization_2" aria-hidden="true"></i>  Immuno-MRM</h6> </a> <div class="characterization_container" id="characterization_2"> <div class="center_align"> <a data-open="characterization_image_2" href="#"> <img class="characterization_image image-characterization" data-full-sized-image="characterization_image_2" data-full-sized-image-path="/file/view/antibody_original/d4575443087ca85b45d05c7244b6ac57" height="300" width="255" alt="Click to enlarge image iMRM screening of CPTC-TIMP1-1 against synthetic peptide GFQALGDAADIR (TIMP Metallopeptidase Inhibitor 1 Peptide 1) Data provided by the Carr Lab, Broad Institute https://www.broadinstitute.org/proteomics/protocols" src="/file/view/antibody/986350e8f49b8c18ee96810e63caa7a2" data-width="430" /> </a> <span>Click image to enlarge</span> </div> <div id="characterization_image_2" class="reveal" style="width: 430px;" data-reveal aria-labelledby="firstModalTitle" aria-hidden="true" role="dialog"> <div class="close-characterization-image" title="Click to close the IHC Cell Line Reference Image"> <a class="close-reveal-modal" aria-label="Close" href="#">×</a> </div> <img alt="iMRM screening of CPTC-TIMP1-1 against synthetic peptide GFQALGDAADIR (TIMP Metallopeptidase Inhibitor 1 Peptide 1) Data provided by the Carr Lab, Broad Institute https://www.broadinstitute.org/proteomics/protocols" src="" /> </div> <h3 class="detail-type-header align-left">CPTC-TIMP1-1 iMRM screening (synthetic peptide)</h3> <div><p>Result: <strong>Positive</strong></p></div> <p class="detail-type-text">iMRM screening of CPTC-TIMP1-1 against synthetic peptide GFQALGDAADIR (TIMP Metallopeptidase Inhibitor 1 Peptide 1)<br /> <br /> Data provided by the Carr Lab, Broad Institute<br /> https://www.broadinstitute.org/proteomics/protocols</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Antibody Evaluation (iMRM) by Carr Laboratory at Broad Institute (92.7 KB)" href="/file/download/characterization_image_sop/10124acd9ecb57e0d8d17d31fef2265b">Antibody Evaluation (iMRM) by Carr Laboratory at Broad Institute (92.7 KB)</a></li> </ul></div> </div> </div> </div> <div class="image-container"> <a href="#" class="characterization_toggle closed" data-char-toggle="characterization_3"> <h6><i class="fa fa-plus characterization_3" aria-hidden="true"></i>  NCI 60 Protein Array</h6> </a> <div class="characterization_container" id="characterization_3"> <h3 class="detail-type-header align-left">CPTC-TIMP1-1 NCI 60 Protein Array</h3> <div><p>Result: <strong>Negative</strong></p></div> <p class="detail-type-text">This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.</p><br /> <div class="download-file-container"> <div class="antibody-char-sop-box"> <h3 class="detail-type-header">Characterization SOP Files</h3> <ul class="sop-file-list"> <li> <img style="border: 0px;" align="absmiddle" alt="Download file document type" src="/resources/images/site/application_pdf.gif" />  <a title="Download Well base Reverse Phase Protein Array (255.5 KB)" href="/file/download/characterization_image_sop/70504d3791f343e723340a182bc244e0">Well base Reverse Phase Protein Array (255.5 KB)</a></li> </ul></div> </div> </div> </div> </div> <div class="top-link"><a title="Back to top of page" href="#top">[top]</a></div> <a name="CPTC-TIMP1-1-SOPs"></a> <div class="clear"></div> </div> </div> <a name="TIMP_Metallopeptidase_Inhibitor_1_Peptide_1"></a> <div class="well"> <div class="detail-type-header"> <a title="hide/show details" class="manageMenuBlock-link" href="javascript:void(0)" onclick="showDataBlock('block-antigen',true)"> <h4><i class="fa fa-minus icon-block-antigen" aria-hidden="true"></i>Antigen: TIMP Metallopeptidase Inhibitor 1 Peptide 1</h4> </a> </div> <div id="antigen-menu-down" title="Click to display Antigen data" class="block_record_menu_down_icon" onclick="manageMenuBlock('top-antigen'); showDataBlock('block-antigen',false)"> </div> <div class="block_record" id="block-antigen"> <a name="TIMP Metallopeptidase Inhibitor 1 Peptide 1-Background"></a> <h5 class="nopadding">Background</h5> <p> <div class="detail-label"><p>NCI Identification Number:</p></div> <div class="detail-value"><p>00327</p></div> <div class="clear"></div> <div class="detail-label"><p>Antigen Name:</p></div> <div class="detail-value"><p>TIMP Metallopeptidase Inhibitor 1 Peptide 1</p></div> <div class="clear"></div> <div class="detail-label"><p>CPTC Name:</p></div> <div class="detail-value"><p>CPTC-TIMP1 Peptide 1</p></div> <div class="clear"></div> <div class="detail-label"><p>Aliases:</p></div> <div class="detail-value"><p>TIMP Metallopeptidase Inhibitor 1; Tissue Inhibitor Of Metalloproteinases 1; Fibroblast Collagenase Inhibitor; Metalloproteinase Inhibitor 1; Collagenase Inhibitor; TIMP-1; CLGI; TIMP; EPA; EPO; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor); Epididymis Secretory Sperm Binding Protein; Erythroid Potentiating Activity; Erythroid-Potentiating Activity; TIMP1; HCI</p></div> <div class="clear"></div> <div class="detail-label"><p>Function:</p></div> <div class="detail-value"><p>This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Lung Giant Cell Carcinoma. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include cytokine activity and protease binding. An important paralog of this gene is TIMP2.Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. </p></div> <div class="clear"></div> <div class="detail-label"><p>Chromosomal Localization:</p></div> <div class="detail-value"><p>Xp11.3 </p></div> <div class="clear"></div> <div class="detail-label"><p>Accession Number:</p></div> <div class="detail-value"><p>XP_016885255.1 </p></div> <div class="clear"></div> <div class="detail-label"><p>UniProt Accession Number:</p></div> <div class="detail-value"><p>P01033</p></div> <div class="clear"></div> <div class="detail-label"><p>DNA Source:</p></div> <div class="detail-value"><p>N/A</p></div> <div class="clear"></div> <div class="detail-label"><p>Immunogen:</p></div> <div class="detail-value"><p>Synthetic Peptide</p></div> <div class="clear"></div> <div class="detail-label"><p>Vector Name:</p></div> <div class="detail-value"><p>N/A</p></div> <div class="clear"></div> <div class="detail-label"><p>Extinction Coefficient:</p></div> <div class="detail-value"><p></p></div> <div class="clear"></div> <div class="detail-label"><p>Buffers:</p></div> <div class="detail-value"><p></p></div> <div class="clear"></div> <div class="detail-label sequence"><p>Expressed Sequence:</p></div> <div class="detail-value sequence"> <p><span class="format-sequence">GFQALGDAADIR</span></p></div> <div class="clear"></div> <div class="detail-label sequence"><p>Native Sequence:</p></div> <div class="detail-value sequence"><p><span class="format-sequence"></span></p></div> <div class="clear"></div> <div class="detail-label"><p>Calculated Isoelectric Point:</p></div> <div class="detail-value"><p></p></div> <div class="clear"></div> <div class="detail-label"><p>Molecular Weight:</p></div> <div class="detail-value"><p>1320</p></div> <div class="clear"></div> <div class="detail-label"><p>Last Updated:</p></div> <div class="detail-value"><p>08/21/2020</p></div> <div class="clear"></div> </p> <a name="TIMP Metallopeptidase Inhibitor 1 Peptide 1-Links"></a> <h3>Links</h3> <p> <ul class="antigen-url-list"> <li> <strong> EnsEMBL </strong> - <a title="View EnsEMBL link in new window" href="http://uswest.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102265;r=X:47582408-47586789" target="_blank">EnsEMBL TIMP1</a> </li> <li> <strong> Entrez </strong> - <a title="View Entrez link in new window" href="https://www.ncbi.nlm.nih.gov/gene/7076" target="_blank">Entrez TIMP1</a> </li> <li> <strong> Uniprot </strong> - <a title="View link in new window" href="https://www.uniprot.org/uniprot/P01033" target="_blank">Uniprot P01033</a> </li> </ul> </p> <a name="TIMP Metallopeptidase Inhibitor 1 Peptide 1-Characterization"></a> <h5>Characterization Data</h5> <a name="TIMP Metallopeptidase Inhibitor 1 Peptide 1-SOPs"></a> <h3>SOPs</h3> <div class="download-file-container"> <p>No SOPs available.</p> <div class="top-link"><a title="Back to top of page" href="#top">[top]</a></div> </div> </div> </div> <div class="clear"></div> <div id="compareModal" class="reveal" data-reveal aria-labelledby="Compare Antibody Details" aria-hidden="true" role="dialog"> <div id="antibody_compare_details"></div> </div> <input id="mouseX" type="hidden" value="0" /> <input id="mouseY" type="hidden" value="0" /> <div id="compare-original-images"></div>  </div> </div> </div>  <div id="adobe-required"> <h3>Don't have Adobe Reader™? 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The Clinical Proteomic Technologies for Cancer | Details for CPTC-TIMP1-1