Genome Integrity Assay Development

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<section id="page-hero" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/09/Group-22.png')" class="dark_mobile bg-size-cover bg-position-center-right page-hero "> <div class="_1300-container inner-content"> <div class="apps-cols"> <div class="mission-copy"> <h1 class="h2-thin nm w">Track genome-wide copy number variation</h1> <div class="description"><p>High-throughput analysis using the single-cell Tapestri Genome Integrity CNV Solution</p> </div> <a style="color: #ffffff; margin: 30px 0 0 0; padding-top: 9px; padding-bottom: 9px;" class="button red-btn" href="/company/contact/" target="">TALK TO A SCIENTIST</a> </div> </div> </div> </section> <section id="multiple-myeloma-panels-categories"> <div class="panels-categories"> <div class="_1300-container inner-content capabilities-links"> <div class="panels-links"> <a href="#resolution" class="cap-link">KEY BENEFITS</a> <a href="#tapestri" class="cap-link">PROCESS</a> <a href="#pharma-assay-primary_applications" class="cap-link">APPLICATIONS</a> <a href="#applications-resources" class="cap-link">RESOURCES</a> <a href="#get_started" class="cap-link">GET STARTED</a> </div> </div> </div> </section> <section id="genome-resolution" class="genome-resolution"> <div class="_1300-container inner-content capabilities-links"> <div class="resolution"> <h2 class="section-title">Single Cell Resolution for Safer Therapies  and Better Outcomes</h2> <div class="description"> <p style="text-align: center;">Genome integrity is essential for predicting therapeutic safety and patient outcomes, whether dealing with cell-based therapies or analyzing heterogeneous tumors. Traditional methods for assessing genome stability are often limited by low throughput or time-consuming clonal outgrowth processes.</p> <p style="text-align: center;">Now, with Mission Bio’s Tapestri Genome Integrity Assay, comprehensively analyze genome-wide copy number variations (CNVs) across thousands of cells in a single assay. This powerful assay enables you to evaluate genome stability within cell therapies and detect aneuploidy in cancer clones with unmatched resolution and scale.</p> </div> </div> <div class="genome-tabs"> <div class="navtabs"> <style> .genome-tabs .navtabs .navtab1.active { background: #3A5485; } .genome-tabs .navtabs .border1.active { background: #3A5485; } </style> <style> .genome-tabs .navtabs .navtab2.active { background: #EB2334; } .genome-tabs .navtabs .border2.active { background: #EB2334; } </style> <div class="navtabs-block"> <div class="navtab active navtab1" data-border="border-tabs1" data-target="navtab1">Cell and Gene Therapy</div> <div class="navtab navtab2" data-border="border-tabs2" data-target="navtab2">Oncology</div> </div> <div id="border-tabs1" class="border-tabs border1 active"></div> <div id="border-tabs2" class="border-tabs border2 "></div> </div> <div class="contenttabs"> <div id="navtab1" class="content active"> <div class="content-info"> <h6 class="content-title">Genome Integrity Characterization of Genome-Edited Cell Therapies for Safety Assessment</h6> <div class="content-image"> <a class="panel-lightbox w-inline-block i-lightbox" title="" href="https://missionbio.com/wp-content/uploads/2024/09/image-35.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2024/09/image-35.png" alt=""> </div> </div> <div class="content-info"> <h6 class="content-title">Detect Genome Editing Outcomes with CNV</h6> <div class="content-description"><p>With the Tapestri single-cell platform you can obtain critical genome editing measurements alongside CNV analysis to validate your engineered cell therapy.</p> </div> <div class="content-image"> <a class="panel-lightbox w-inline-block i-lightbox" title="" href="https://missionbio.com/wp-content/uploads/2024/09/image.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2024/09/image.png" alt=""> </div> </div> <div class="content-info"> <div class="content-description"><p><a class="button short-btn red-btn" style="margin: 0 auto; width: max-content; max-width: max-content;" href="https://missionbio.com/applications/genome-editing/">Learn More About the Tapestri Genome Editing Solution</a></p> </div> </div> </div> <div id="navtab2" class="content "> <div class="content-info"> <h6 class="content-title">Chromosomal Instability Characterization of Tumor Samples to Elucidate the Mechanisms of Adaptability and Resistance in Cancer</h6> <div class="content-image"> <a class="panel-lightbox w-inline-block i-lightbox" title="" href="https://missionbio.com/wp-content/uploads/2024/09/image-42.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2024/09/image-42.png" alt=""> </div> </div> <div class="content-info"> <h6 class="content-title">Genome Integrity Assay Reveals CNV Signature and Clonal Architecture</h6> <div class="content-description"><p>Tapestri Genome Integrity CNV analysis of Raji cells copy number variants (CNVs) on the p and q arms of several chromosomes in all cells. The analysis also uncovered CNVs that distinguish unique clones. Clone 2 has a unique copy gain on chromosome 2p and a loss on chromosome 9p, and Clone 3 has a copy gain of the entire chromosomes 7 and 20. The cells comprise 1 sample of a 3-sample multiplexed Tapestri run (n= 1,494 cells analyzed).</p> </div> <div class="content-image"> <a class="panel-lightbox w-inline-block i-lightbox" title="" href="https://missionbio.com/wp-content/uploads/2024/09/gwcnv.clonalheterogeneity.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2024/09/gwcnv.clonalheterogeneity.png" alt=""> </div> </div> </div> </div> </div> </div> </section> <section id="tapestri" class="tapestri-section"> <div class="_1300-container inner-content"> <h2 class="section_title">Tapestri Genome Integrity Assay</h2> <div class="subtitle">Everything you need to conduct single-cell multiomics analysis of  genome-wide CNV.</div> <div class="flex-25-75"> <div class="description"> <ul class="list-style-plus"> <li>Tapestri Instrument</li> <li>Tapestri Single-cell Genome  Integrity Solution including: <ul> <li>DNA + Protein Core Kit</li> <li>Genome-Wide CNV Panel</li> <li>Custom-Designed or   Catalog DNA Panel   (+ Optional Protein Panel)</li> </ul> </li> <li>Software-Based Analysis  (via Portal Access or  On-Premise Activation)</li> <li>Optional Sample Multiplexing</li> </ul> </div> <div class="info"> <img class="info_image" src="https://missionbio.com/wp-content/uploads/2024/09/MBIO_GenomeIntegrity_TapestriSet_v3Box.png" alt=""> </div> </div> </div> </section> <section id="tapestri_workflow" class="tapestri_workflow-section"> <div class="_1300-container inner-content"> <div class="grey-bg"> <div class="white-bg"> <img src="https://missionbio.com/wp-content/uploads/2024/09/MBIO_Tapestri-GenomeIntegrity-Workflow.png" alt=""> </div> </div> </div> </section> <section id="pharma-assay-primary_applications" class="primary_applications_section"> <div class="_1300-container inner-content key-benefits"> <h2 class="section_title">Explore Genome Integrity Services by Application</h2> <div class="applications-cols"> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/06/Rectangle-127.png')"> <div class="applications-info"> <div class="applications-info__heading"> <h4 class="name">Safety Assessment of  Cell-Based Therapies</h4> <div class="description"><ul> <li>Combine gene editing and genome integrity analysis for safety profiling</li> <li>Assess stem cells after reprogramming or differentiation for genomic aberrations</li> </ul> </div> </div> <a class="button" href="/applications/cell-and-gene-therapy/" target=""">LEARN MORE <svg xmlns="http://www.w3.org/2000/svg" width="16" height="8" viewBox="0 0 16 8" fill="none"> <path d="M0.5 4.5C0.223858 4.5 -3.54637e-08 4.27614 0 4C5.66101e-09 3.72386 0.223858 3.5 0.5 3.5L0.5 4.5ZM15.8536 3.64645C16.0488 3.84171 16.0488 4.15829 15.8536 4.35355L12.6716 7.53553C12.4763 7.73079 12.1597 7.73079 11.9645 7.53553C11.7692 7.34027 11.7692 7.02369 11.9645 6.82843L14.7929 4L11.9645 1.17157C11.7692 0.976309 11.7692 0.659727 11.9645 0.464465C12.1597 0.269202 12.4763 0.269203 12.6716 0.464465L15.8536 3.64645ZM0.5 3.5L15.5 3.5L15.5 4.5L0.5 4.5L0.5 3.5Z" fill="#53B4D3"/> </svg> </a> </div> </div> <div class="applications-card" style="background-image: url('https://missionbio.com/wp-content/uploads/2024/06/Rectangle-38.png')"> <div class="applications-info"> <div class="applications-info__heading"> <h4 class="name">Characterization  of chromosomal instability in cancer</h4> <div class="description"><ul> <li>Assess clonal/subclonal heterogeneity of CNVs linked to tumor evolution and immune evasion</li> <li>Identify CNV events underlying therapy resistance and disease relapse</li> <li>Correlate CNV, SNV, and surface immunophenotypic measurements at a single-cell resolution</li> </ul> </div> </div> <a class="button" href="/applications/oncology/" target=""">LEARN MORE <svg xmlns="http://www.w3.org/2000/svg" width="16" height="8" viewBox="0 0 16 8" fill="none"> <path d="M0.5 4.5C0.223858 4.5 -3.54637e-08 4.27614 0 4C5.66101e-09 3.72386 0.223858 3.5 0.5 3.5L0.5 4.5ZM15.8536 3.64645C16.0488 3.84171 16.0488 4.15829 15.8536 4.35355L12.6716 7.53553C12.4763 7.73079 12.1597 7.73079 11.9645 7.53553C11.7692 7.34027 11.7692 7.02369 11.9645 6.82843L14.7929 4L11.9645 1.17157C11.7692 0.976309 11.7692 0.659727 11.9645 0.464465C12.1597 0.269202 12.4763 0.269203 12.6716 0.464465L15.8536 3.64645ZM0.5 3.5L15.5 3.5L15.5 4.5L0.5 4.5L0.5 3.5Z" fill="#53B4D3"/> </svg> </a> </div> </div> </div> </div> </section> <section id="single-cell" class="single-cell"> <div class="_1300-container inner-content"> <div class="single-cell-content"> <h2 class="section_title">Single-Cell DNA Genome-Wide CNV Panel</h2> <div class="description"><p>• 500 amplicon panel uniformly covering nearly the entire genome<br /> • Amplicons spaced average 5.8Mb apart<br /> • Panel Uniformity: 96.7%</p> </div> <div class="content-image"> <a class="panel-lightbox w-inline-block i-lightbox" title="" href="https://missionbio.com/wp-content/uploads/2024/09/image-33.png"> <img src="/wp-content/themes/missionbio-v2/images/Zoom.svg" alt="click to zoom" class="zoom"> </a> <img class="main_image" src="https://missionbio.com/wp-content/uploads/2024/09/image-33.png" alt=""> </div> </div> </div> </section> <div id="Case-Study" class="panels-section case-study testimonial new-testimonial"> <div class="_1300-container inner-content panels-details"> <div class="mission-cols"> <div class="application-image case-study avatar" style="background-image: url(https://missionbio.com/wp-content/uploads/2024/09/Ellipse-7.png);"> </div> <div class="panel-col"> <div class="description">“Mission Bio’s Tapestri platform gave our team the flexibility and customizability necessary to push our understanding of aneuploidy across thousands of single cells simultaneously.”</div> <div class="name-institution"> <p class="name" style="color: #FFF;">Dr. Teresa Davoli</p> <p class="institution" style="color: #FFF;">NYU School of Medicine</p> </div> <div class="divider"></div> </div> </div> </div> </div> <section id="applications-resources" class="h-resources" style=""> <div class="_1300-container inner-content"> <h2 class="section_title w" style="">Featured Resources </h2> <div class="h-resources-grid"> <div class="h-resource-card tn" data-ix="show-more-link"> <div class="h-resource-image tn" ></div> <div class="h-resource-content"> <div class="h-resource-category d tn"> PUBLICATION </div> <a href="https://missionbio.com/resources/publications/karyotap-enables-aneuploidy-detection-in-thousands-of-single-human-cells/" class="h-resource-title-link"> KaryoTap Enables Aneuploidy Detection in Thousands of Single Human Cells </a> <br/> <a href="https://missionbio.com/resources/publications/karyotap-enables-aneuploidy-detection-in-thousands-of-single-human-cells/" class="more-link">LEARN MORE</a> </div> </div> <div class="h-resource-divider"></div> <div class="h-resource-card p" 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begin your evaluation</p> </div> <a href="/company/contact/" class="button w wo r w-button">CONTACT US</a> <div class="mb30 w get_started_bottom_description"><p> </p> <p>*The content provided herein may relate to products that have not been fully validated by Mission Bio and is subject to change without notice.</p> <p>For Research Use Only. 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