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href="download.shtml">Download</a></li> <li><a href="notice.shtml">Public Domain Notice and Reference</a></li> <li><a href="contact.shtml">Contact Information</a></li> </ul>  </div> </div> <div class="global_content">  <h1>Complementary Pairs Stability Selection for Genome-Wide Association Studies (ComPaSS-GWAS)</h1> <p>ComPaSS-GWAS, <strong>Comp</strong>lementary <strong>Pa</strong>irs <strong>S</strong>tability <strong>S</strong>election for <strong>G</strong>enome-<strong>W</strong>ide <strong>A</strong>ssociation <strong>S</strong>tudies, is an approach based on complementary-pairs stability selection that has been proposed as an ad-hoc alternative to replication (Sabourin et al., in press). In this method, the sample is randomly split into two conditionally independent halves multiple times (resamples) and a GWAS is performed on each half in each resample. Similar in spirit to testing for association with independent discovery and replication samples, a marker is corroborated if its p-value is significant in both halves of the resample.</p> <p>Simulation experiments were performed for both non-genetic and genetic models. Simulation results show that ComPaSS-GWAS has better type I error control than splitting the data into a single discovery and replication sample (i.e., a two-stage GWAS), with power roughly equal to that of a traditional GWAS of the full data. An efficient implementation of ComPaSS-GWAS utilizing PLINK 1.9 is available as an R-package.</p> <p class="lastmodified">Last Modified: Friday, 28-Sep-2018 13:23:31 EDT</p>  </div> <div class="clear"></div> </div>  <div id="globalfooter"> <div id="logos"> <a href="https://www.hhs.gov/"><img src="/include/images/logo_hhs.gif" alt="Department of Health and Human Services" /></a> <a href="https://www.nih.gov/"><img src="/include/images/logo_nih.gif" alt="National Institutes of Health" /></a> <a href="https://www.usa.gov"><img src="/include/images/logo_usagov-color.gif" alt="USA.gov" /></a> </div> <div id="nav">  |  <a href="https://www.genome.gov/about-nhgri/Policies-Guidance/Privacy">Privacy</a>  |  <a href="https://www.genome.gov/about-nhgri/Policies-Guidance/Copyright">Copyright</a>  |  <a href="https://www.genome.gov/about-nhgri/Contact">Contact</a>  |  <a href="https://www.genome.gov/about-nhgri/Policies-Guidance/Accessibility">Accessibility</a>  |  <a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html">HHS Vulnerability Disclosure</a>  |  <a href="https://www.hhs.gov/plugins.html">Plug-ins</a>  |  <a href="https://www.genome.gov/about-nhgri/Policies-Guidance/Site-Map">Site Map</a>  |  <a href="https://www.genome.gov/staff">Staff Directory</a>  |  <a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office">FOIA</a></div> </div> </body> <script type="text/javascript" src="/include/genome_public/scripts/genome-search.js"></script> </html>