CINXE.COM

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col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>FGF Family Signaling Pathways</h1> <p id="pw-intro-txt">Click on one of the FGF subfamilies shown in the Explore Pathways box below to see additional information about the FGF ligands belonging to each subfamily. Refer to the table below the pathway to see the reported receptor binding specificities for the different FGF ligands, their physiological functions, and the pathologies associated with mutations or amplification of different FGFs.<br></p> <div id="pw-con" data-mapname="" data-primary_segment="fgfsignaling_all"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"> <li data-segment="FGF_1" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGF_1" class="pw_rdblue_sm pw_sm_btn"><span>FGF-1</span></li> <li data-segment="FGF_4" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGF_4" class="pw_rdblue_sm pw_sm_btn"><span>FGF-4</span></li> <li data-segment="FGF_7" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGF_7" class="pw_rdblue_sm pw_sm_btn"><span>FGF-7</span></li> <li data-segment="FGF_8" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGF_8" class="pw_rdblue_sm pw_sm_btn"><span>FGF-8</span></li> <li data-segment="FGF_9" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGF_9" class="pw_rdblue_sm pw_sm_btn"><span>FGF-9</span></li> <li data-segment="FGF_11" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGF_11" class="pw_rdblue_sm pw_sm_btn"><span>FGF-11</span></li> <li data-segment="FGF_19" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGF_19" class="pw_rdblue_sm pw_sm_btn"><span>FGF-19</span></li> <li data-segment="FGFSignaling_All" data-background_image="fgfsignaling_static.png" data-pathway_segment="Pathway_FGFSignaling_All" class="pw_sm_btn-active"><span>View Full Pathway</span></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> FGF Family Signaling Pathways </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray1 pw-gray" style="top:169.66668701171875px;left:336.33331298828125px;"> </div> <div id="el1_off" data-id="1" data-set="FGFDimer1" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off1" style="top:169.66668701171875px;left:336.33331298828125px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fgf-acidic">FGF acidic</a><br><a href="https://www.rndsystems.com/target/fgf-basic">FGF basic</a><br><a href="https://www.rndsystems.com/target/fgf-3">FGF-3</a><br><a href="https://www.rndsystems.com/target/fgf-4">FGF-4</a><br><a href="https://www.rndsystems.com/target/fgf-5">FGF-5</a><br><a href="https://www.rndsystems.com/target/fgf-6">FGF-6</a><br><a href="https://www.rndsystems.com/target/kgf-fgf-7">KGF/FGF-7</a><br><a href="https://www.rndsystems.com/target/fgf-8">FGF-8</a><br><a href="https://www.rndsystems.com/target/fgf-9">FGF-9</a><br><a href="https://www.rndsystems.com/target/fgf-10">FGF-10</a><br><a href="https://www.rndsystems.com/target/fgf-11">FGF-11</a><br><a href="https://www.rndsystems.com/target/fgf-12">FGF-12</a><br><a href="https://www.rndsystems.com/target/fgf-13">FGF-13</a><br><a href="Product Suggestion Box">FGF-14</a><br><a href="https://www.rndsystems.com/target/fgf-15">FGF-15</a><br><a href="https://www.rndsystems.com/target/fgf-16">FGF-16</a><br><a href="https://www.rndsystems.com/target/fgf-17">FGF-17</a><br><a href="https://www.rndsystems.com/target/fgf-18">FGF-18</a><br><a href="https://www.rndsystems.com/target/fgf-19">FGF-19</a><br><a href="https://www.rndsystems.com/target/fgf-20">FGF-20</a><br><a href="https://www.rndsystems.com/target/fgf-21">FGF-21</a><br><a href="https://www.rndsystems.com/target/fgf-22">FGF-22</a><br><a href="https://www.rndsystems.com/target/fgf-23">FGF-23</a><br> </div> </div> <div id="el2_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray2 pw-gray" style="top:135px;left:260.33331298828125px;"> FGF Dimer </div> <div id="el2_off" data-id="2" data-set="FGFDimer1" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off2" style="top:135px;left:260.33331298828125px;"> FGF Dimer</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fgf-acidic">FGF acidic</a><br> <a href="https://www.rndsystems.com/target/fgf-basic">FGF basic</a><br> <a href="https://www.rndsystems.com/target/fgf-3">FGF-3</a><br> <a href="https://www.rndsystems.com/target/fgf-4">FGF-4</a><br> <a href="https://www.rndsystems.com/target/fgf-5">FGF-5</a><br> <a href="https://www.rndsystems.com/target/fgf-6">FGF-6</a><br> <a href="https://www.rndsystems.com/target/kgf-fgf-7">KGF/FGF-7</a><br> <a href="https://www.rndsystems.com/target/fgf-8">FGF-8</a><br> <a href="https://www.rndsystems.com/target/fgf-9">FGF-9</a><br> <a href="https://www.rndsystems.com/target/fgf-10">FGF-10</a><br> <a href="https://www.rndsystems.com/target/fgf-11">FGF-11</a><br> <a href="https://www.rndsystems.com/target/fgf-12">FGF-12</a><br> <a href="https://www.rndsystems.com/target/fgf-13">FGF-13</a><br> <a href="https://www.rndsystems.com/target/fgf-15">FGF-15</a><br> <a href="https://www.rndsystems.com/target/fgf-16">FGF-16</a><br> <a href="https://www.rndsystems.com/target/fgf-17">FGF-17</a><br> <a href="https://www.rndsystems.com/target/fgf-18">FGF-18</a><br> <a href="https://www.rndsystems.com/target/fgf-19">FGF-19</a><br> <a href="https://www.rndsystems.com/target/fgf-20">FGF-20</a><br> <a href="https://www.rndsystems.com/target/fgf-21">FGF-21</a><br> <a href="https://www.rndsystems.com/target/fgf-22">FGF-22</a><br> <a href="https://www.rndsystems.com/target/fgf-23">FGF-23</a><br> </div> </div> <div id="el3_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray3 pw-gray" style="top:135.66668701171875px;left:328.33331298828125px;"> </div> <div id="el3_off" data-id="3" data-set="FGFRDimer2" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off3" style="top:135.66668701171875px;left:328.33331298828125px;"> </div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fgf-r1">FGF R1</a><br><a href="https://www.rndsystems.com/target/fgf-r1-alpha">FGF R1 alpha</a><br><a href="https://www.rndsystems.com/target/fgf-r1-beta">FGF R1 beta</a><br><a href="https://www.rndsystems.com/target/fgf-r2">FGF R2</a><br><a href="https://www.rndsystems.com/target/fgf-r2-alpha">FGF R2 alpha</a><br><a href="https://www.rndsystems.com/target/fgf-r2-beta">FGF R2 beta</a><br><a href="https://www.rndsystems.com/target/fgf-r3">FGF R3</a><br><a href="https://www.rndsystems.com/target/fgf-r4">FGF R4</a><br><a href="https://www.rndsystems.com/target/fgf-r5-fgfrl1">FGF R5</a><br> </div> </div> <div id="el4_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray4 pw-gray" style="top:136px;left:371px;"> FGF R Dimer </div> <div id="el4_off" data-id="4" data-set="FGFRDimer2" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off4" style="top:136px;left:371px;"> FGF R Dimer</div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fgf-r1">FGF R1</a><br> <a href="https://www.rndsystems.com/target/fgf-r1-alpha">FGF R1 alpha</a><br> <a href="https://www.rndsystems.com/target/fgf-r1-beta">FGF R1 beta</a><br> <a href="https://www.rndsystems.com/target/fgf-r2">FGF R2</a><br> <a href="https://www.rndsystems.com/target/fgf-r2-alpha">FGF R2 alpha</a><br> <a href="https://www.rndsystems.com/target/fgf-r2-beta">FGF R2 beta</a><br> <a href="https://www.rndsystems.com/target/fgf-r3">FGF R3</a><br> <a href="https://www.rndsystems.com/target/fgf-r4">FGF R4</a><br> </div> </div> <div id="el5_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray5 pw-gray" style="top:151.66668701171875px;left:297.33331298828125px;"> </div> <div id="el5_off" data-id="5" data-set="HSPG3" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off5" style="top:151.66668701171875px;left:297.33331298828125px;"> </div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/syndecan-1-cd138">Syndecan-1</a><br><a href="https://www.rndsystems.com/target/syndecan-2-cd362">Syndecan-2</a><br><a href="https://www.rndsystems.com/target/syndecan-3">Syndecan-3</a><br><a href="https://www.rndsystems.com/target/syndecan-4">Syndecan-4</a><br><a href="https://www.rndsystems.com/target/glypican-1">Glypican 1</a><br><a href="https://www.rndsystems.com/target/glypican-2">Glypican 2</a><br><a href="https://www.rndsystems.com/target/glypican-3">Glypican 3</a><br><a href="https://www.rndsystems.com/target/glypican-4">Glypican 4</a><br><a href="https://www.rndsystems.com/target/glypican-5">Glypican 5</a><br><a href="https://www.rndsystems.com/target/glypican-6">Glypican 6</a><br><a href="https://www.rndsystems.com/target/endorepellin-perlecan">Endorepellin</a><br> <a href="https://www.rndsystems.com/search?keywords=hspg">All HSPG Products</a><br> </div> </div> <div id="el6_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray6 pw-gray" style="top:165.66668701171875px;left:278.33331298828125px;"> HSPG </div> <div id="el6_off" data-id="6" data-set="HSPG3" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off6" style="top:165.66668701171875px;left:278.33331298828125px;"> HSPG</div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/syndecan-1-cd138">Syndecan-1</a><br><a href="https://www.rndsystems.com/target/syndecan-2-cd362">Syndecan-2</a><br><a href="https://www.rndsystems.com/target/syndecan-3">Syndecan-3</a><br><a href="https://www.rndsystems.com/target/syndecan-4">Syndecan-4</a><br><a href="https://www.rndsystems.com/target/glypican-1">Glypican 1</a><br><a href="https://www.rndsystems.com/target/glypican-2">Glypican 2</a><br><a href="https://www.rndsystems.com/target/glypican-3">Glypican 3</a><br><a href="https://www.rndsystems.com/target/glypican-4">Glypican 4</a><br><a href="https://www.rndsystems.com/target/glypican-5">Glypican 5</a><br><a href="https://www.rndsystems.com/target/glypican-6">Glypican 6</a><br><a href="https://www.rndsystems.com/target/endorepellin-perlecan">Endorepellin</a><br> <a href="https://www.rndsystems.com/search?keywords=hspg">All HSPG Products</a><br> </div> </div> <div id="el7_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray7 pw-gray" style="top:150.66668701171875px;left:323.33331298828125px;"> </div> <div id="el7_off" data-id="7" data-set="HSPG4" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off7" style="top:150.66668701171875px;left:323.33331298828125px;"> </div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/syndecan-1-cd138">Syndecan-1</a><br><a href="https://www.rndsystems.com/target/syndecan-2-cd362">Syndecan-2</a><br><a href="https://www.rndsystems.com/target/syndecan-3">Syndecan-3</a><br><a href="https://www.rndsystems.com/target/syndecan-4">Syndecan-4</a><br><a href="https://www.rndsystems.com/target/glypican-1">Glypican 1</a><br><a href="https://www.rndsystems.com/target/glypican-2">Glypican 2</a><br><a href="https://www.rndsystems.com/target/glypican-3">Glypican 3</a><br><a href="https://www.rndsystems.com/target/glypican-4">Glypican 4</a><br><a href="https://www.rndsystems.com/target/glypican-5">Glypican 5</a><br><a href="https://www.rndsystems.com/target/glypican-6">Glypican 6</a><br><a href="https://www.rndsystems.com/target/endorepellin-perlecan">Endorepellin</a><br> <a href="https://www.rndsystems.com/search?keywords=hspg">All HSPG Products</a><br> </div> </div> <div id="el8_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray8 pw-gray" style="top:162.66668701171875px;left:391.33331298828125px;"> HSPG </div> <div id="el8_off" data-id="8" data-set="HSPG4" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off8" style="top:162.66668701171875px;left:391.33331298828125px;"> HSPG</div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/syndecan-1-cd138">Syndecan-1</a><br><a href="https://www.rndsystems.com/target/syndecan-2-cd362">Syndecan-2</a><br><a href="https://www.rndsystems.com/target/syndecan-3">Syndecan-3</a><br><a href="https://www.rndsystems.com/target/syndecan-4">Syndecan-4</a><br><a href="https://www.rndsystems.com/target/glypican-1">Glypican 1</a><br><a href="https://www.rndsystems.com/target/glypican-2">Glypican 2</a><br><a href="https://www.rndsystems.com/target/glypican-3">Glypican 3</a><br><a href="https://www.rndsystems.com/target/glypican-4">Glypican 4</a><br><a href="https://www.rndsystems.com/target/glypican-5">Glypican 5</a><br><a href="https://www.rndsystems.com/target/glypican-6">Glypican 6</a><br><a href="https://www.rndsystems.com/target/endorepellin-perlecan">Endorepellin</a><br> <a href="https://www.rndsystems.com/search?keywords=hspg">All HSPG Products</a><br> </div> </div> <div id="el9_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray9 pw-gray" style="top:227.66668701171875px;left:317.33331298828125px;"> </div> <div id="el9_off" data-id="9" data-set="FRS25" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off9" style="top:227.66668701171875px;left:317.33331298828125px;"> </div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/frs2">FRS2</a><br> </div> </div> <div id="el10_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray10 pw-gray" style="top:232.66668701171875px;left:272.33331298828125px;"> FRS2 </div> <div id="el10_off" data-id="10" data-set="FRS25" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off10" style="top:232.66668701171875px;left:272.33331298828125px;"> FRS2</div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/frs2">FRS2</a><br> </div> </div> <div id="el11_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray11 pw-gray" style="top:231.66668701171875px;left:303.33331298828125px;"> </div> <div id="el11_off" data-id="11" data-set="Cbl6" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off11" style="top:231.66668701171875px;left:303.33331298828125px;"> </div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/cbl">Cbl</a><br> </div> </div> <div id="el12_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray12 pw-gray" style="top:247.66668701171875px;left:288.33331298828125px;"> Cbl </div> <div id="el12_off" data-id="12" data-set="Cbl6" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off12" style="top:247.66668701171875px;left:288.33331298828125px;"> Cbl</div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/cbl">Cbl</a><br> </div> </div> <div id="el13_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray13 pw-gray" style="top:244.66668701171875px;left:316.33331298828125px;"> </div> <div id="el13_off" data-id="13" data-set="GRB27" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off13" style="top:244.66668701171875px;left:316.33331298828125px;"> </div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el14_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray14 pw-gray" style="top:266.66668701171875px;left:290.33331298828125px;"> GRB2 </div> <div id="el14_off" data-id="14" data-set="GRB27" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off14" style="top:266.66668701171875px;left:290.33331298828125px;"> GRB2</div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el15_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray15 pw-gray" style="top:229.6666717529297px;left:209.33331298828125px;"> </div> <div id="el15_off" data-id="15" data-set="Src8" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off15" style="top:229.6666717529297px;left:209.33331298828125px;"> </div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/src">Src</a><br> </div> </div> <div id="el16_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray16 pw-gray" style="top:244.6666717529297px;left:194.33331298828125px;"> Src </div> <div id="el16_off" data-id="16" data-set="Src8" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off16" style="top:244.6666717529297px;left:194.33331298828125px;"> Src</div> <div id="el16_ct" class="pw-tooltip" data-id="16"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/src">Src</a><br> </div> </div> <div id="el17_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray17 pw-gray" style="top:266.66668701171875px;left:184.33331298828125px;"> </div> <div id="el17_off" data-id="17" data-set="Shb9" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off17" style="top:266.66668701171875px;left:184.33331298828125px;"> </div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/shb">Shb</a><br> </div> </div> <div id="el18_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray18 pw-gray" style="top:271.66668701171875px;left:166.33331298828125px;"> Shb </div> <div id="el18_off" data-id="18" data-set="Shb9" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off18" style="top:271.66668701171875px;left:166.33331298828125px;"> Shb</div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/shb">Shb</a><br> </div> </div> <div id="el19_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray19 pw-gray" style="top:222.6666717529297px;left:358.33331298828125px;"> </div> <div id="el19_off" data-id="19" data-set="FRS210" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off19" style="top:222.6666717529297px;left:358.33331298828125px;"> </div> <div id="el19_ct" class="pw-tooltip" data-id="19"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/frs2">FRS2</a><br> </div> </div> <div id="el20_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray20 pw-gray" style="top:198.6666717529297px;left:383.33331298828125px;"> FRS2 </div> <div id="el20_off" data-id="20" data-set="FRS210" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off20" style="top:198.6666717529297px;left:383.33331298828125px;"> FRS2</div> <div id="el20_ct" class="pw-tooltip" data-id="20"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/frs2">FRS2</a><br> </div> </div> <div id="el21_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray21 pw-gray" style="top:222.6666717529297px;left:373.33331298828125px;"> </div> <div id="el21_off" data-id="21" data-set="SHP-211" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off21" style="top:222.6666717529297px;left:373.33331298828125px;"> </div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/shp-2">SHP-2</a><br> </div> </div> <div id="el22_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray22 pw-gray" style="top:205.6666717529297px;left:418.33331298828125px;"> SHP-2 </div> <div id="el22_off" data-id="22" data-set="SHP-211" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off22" style="top:205.6666717529297px;left:418.33331298828125px;"> SHP-2</div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/shp-2">SHP-2</a><br> </div> </div> <div id="el23_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray23 pw-gray" style="top:236.6666717529297px;left:365.33331298828125px;"> </div> <div id="el23_off" data-id="23" data-set="GRB212" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off23" style="top:236.6666717529297px;left:365.33331298828125px;"> </div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el24_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray24 pw-gray" style="top:262.66668701171875px;left:377.33331298828125px;"> GRB2 </div> <div id="el24_off" data-id="24" data-set="GRB212" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off24" style="top:262.66668701171875px;left:377.33331298828125px;"> GRB2</div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el25_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray25 pw-gray" style="top:240.6666717529297px;left:381.33331298828125px;"> </div> <div id="el25_off" data-id="25" data-set="SOS13" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off25" style="top:240.6666717529297px;left:381.33331298828125px;"> </div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/sos2">SOS2</a><br> </div> </div> <div id="el26_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray26 pw-gray" style="top:238.6666717529297px;left:404.33331298828125px;"> SOS </div> <div id="el26_off" data-id="26" data-set="SOS13" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off26" style="top:238.6666717529297px;left:404.33331298828125px;"> SOS</div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/sos2">SOS2</a><br> </div> </div> <div id="el27_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray27 pw-gray" style="top:273.66668701171875px;left:365.33331298828125px;"> </div> <div id="el27_off" data-id="27" data-set="GRB214" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off27" style="top:273.66668701171875px;left:365.33331298828125px;"> </div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el28_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray28 pw-gray" style="top:298.66668701171875px;left:371.33331298828125px;"> GRB2 </div> <div id="el28_off" data-id="28" data-set="GRB214" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off28" style="top:298.66668701171875px;left:371.33331298828125px;"> GRB2</div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el29_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray29 pw-gray" style="top:273.66668701171875px;left:381.33331298828125px;"> </div> <div id="el29_off" data-id="29" data-set="Gab115" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off29" style="top:273.66668701171875px;left:381.33331298828125px;"> </div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GAB1">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el30_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray30 pw-gray" style="top:286.66668701171875px;left:405.33331298828125px;"> Gab1 </div> <div id="el30_off" data-id="30" data-set="Gab115" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off30" style="top:286.66668701171875px;left:405.33331298828125px;"> Gab1</div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GAB1">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el31_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray31 pw-gray" style="top:300.66668701171875px;left:494.33331298828125px;"> </div> <div id="el31_off" data-id="31" data-set="Shc16" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off31" style="top:300.66668701171875px;left:494.33331298828125px;"> </div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/shc1">SHC1</a><br> </div> </div> <div id="el32_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray32 pw-gray" style="top:312.66668701171875px;left:478.33331298828125px;"> Shc </div> <div id="el32_off" data-id="32" data-set="Shc16" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off32" style="top:312.66668701171875px;left:478.33331298828125px;"> Shc</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/shc1">SHC1</a><br> </div> </div> <div id="el33_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray33 pw-gray" style="top:302.66668701171875px;left:509.33331298828125px;"> </div> <div id="el33_off" data-id="33" data-set="GRB217" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off33" style="top:302.66668701171875px;left:509.33331298828125px;"> </div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el34_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray34 pw-gray" style="top:326.66668701171875px;left:494.33331298828125px;"> GRB2 </div> <div id="el34_off" data-id="34" data-set="GRB217" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off34" style="top:326.66668701171875px;left:494.33331298828125px;"> GRB2</div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/grb2">GRB2</a><br> </div> </div> <div id="el35_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray35 pw-gray" style="top:286.66668701171875px;left:513.3333129882812px;"> </div> <div id="el35_off" data-id="35" data-set="Crk18" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off35" style="top:286.66668701171875px;left:513.3333129882812px;"> </div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/crk">Crk</a><br><a href="https://www.rndsystems.com/target/crkl">CrkL</a><br> </div> </div> <div id="el36_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray36 pw-gray" style="top:293.66668701171875px;left:538.3333129882812px;"> Crk </div> <div id="el36_off" data-id="36" data-set="Crk18" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off36" style="top:293.66668701171875px;left:538.3333129882812px;"> Crk</div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/crk">Crk</a><br><a href="https://www.rndsystems.com/target/crkl">CrkL</a><br> </div> </div> <div id="el37_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray37 pw-gray" style="top:307.66668701171875px;left:525.3333129882812px;"> </div> <div id="el37_off" data-id="37" data-set="SOS19" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off37" style="top:307.66668701171875px;left:525.3333129882812px;"> </div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="Product Suggestion Box">SOS1</a><br><a href="https://www.rndsystems.com/target/sos2">SOS2</a><br> </div> </div> <div id="el38_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray38 pw-gray" style="top:328.66668701171875px;left:540.3333129882812px;"> SOS </div> <div id="el38_off" data-id="38" data-set="SOS19" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off38" style="top:328.66668701171875px;left:540.3333129882812px;"> SOS</div> <div id="el38_ct" class="pw-tooltip" data-id="38"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/sos2">SOS2</a><br> </div> </div> <div id="el39_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 pw-center el-gray39 pw-gray" style="top:182px;left:155px;"> Ubiquitin-dependent<br>Degradation </div> <div id="el39_off" data-id="39" data-set="Ubiquitin-dependentDegradation" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 pw-center el-off39" style="top:182px;left:155px;"> Ubiquitin-dependent<br>Degradation</div> <div id="el39_ct" class="pw-tooltip" data-id="39"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el40_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray40 pw-gray" style="top:301.66668701171875px;left:323.33331298828125px;"> </div> <div id="el40_off" data-id="40" data-set="PLC-gamma21" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off40" style="top:301.66668701171875px;left:323.33331298828125px;"> </div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/plc-gamma-1">PLC-gamma 1</a><br><a href="https://www.rndsystems.com/target/plc-gamma-2">PLC-gamma 2</a><br> </div> </div> <div id="el41_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray41 pw-gray" style="top:314.66668701171875px;left:257.33331298828125px;"> PLC-gamma </div> <div id="el41_off" data-id="41" data-set="PLC-gamma21" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off41" style="top:314.66668701171875px;left:257.33331298828125px;"> PLC-gamma</div> <div id="el41_ct" class="pw-tooltip" data-id="41"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/plc-gamma-1">PLC-gamma 1</a><br><a href="https://www.rndsystems.com/target/plc-gamma-2">PLC-gamma 2</a><br> </div> </div> <div id="el42_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray42 pw-gray" style="top:257.66668701171875px;left:86.33331298828125px;"> </div> <div id="el42_off" data-id="42" data-set="PIP222" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off42" style="top:257.66668701171875px;left:86.33331298828125px;"> </div> <div id="el42_ct" class="pw-tooltip" data-id="42"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIP2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el43_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray43 pw-gray" style="top:265.66668701171875px;left:118.33331298828125px;"> PIP2 </div> <div id="el43_off" data-id="43" data-set="PIP222" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off43" style="top:265.66668701171875px;left:118.33331298828125px;"> PIP2</div> <div id="el43_ct" class="pw-tooltip" data-id="43"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIP2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el44_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray44 pw-gray" style="top:309.66668701171875px;left:58.33331298828125px;"> </div> <div id="el44_off" data-id="44" data-set="DAG23" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off44" style="top:309.66668701171875px;left:58.33331298828125px;"> </div> <div id="el44_ct" class="pw-tooltip" data-id="44"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=DAG">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el45_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray45 pw-gray" style="top:318.66668701171875px;left:33.33331298828125px;"> DAG </div> <div id="el45_off" data-id="45" data-set="DAG23" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off45" style="top:318.66668701171875px;left:33.33331298828125px;"> DAG</div> <div id="el45_ct" class="pw-tooltip" data-id="45"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=DAG">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el46_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray46 pw-gray" style="top:314.66668701171875px;left:95.33331298828125px;"> </div> <div id="el46_off" data-id="46" data-set="IP324" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off46" style="top:314.66668701171875px;left:95.33331298828125px;"> </div> <div id="el46_ct" class="pw-tooltip" data-id="46"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=IP3">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el47_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray47 pw-gray" style="top:325.66668701171875px;left:119.33331298828125px;"> IP3 </div> <div id="el47_off" data-id="47" data-set="IP324" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off47" style="top:325.66668701171875px;left:119.33331298828125px;"> IP3</div> <div id="el47_ct" class="pw-tooltip" data-id="47"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=IP3">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el48_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray48 pw-gray" style="top:351.66668701171875px;left:40.33331298828125px;"> </div> <div id="el48_off" data-id="48" data-set="PKC25" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off48" style="top:351.66668701171875px;left:40.33331298828125px;"> </div> <div id="el48_ct" class="pw-tooltip" data-id="48"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pkc-alpha">PKC alpha</a><br><a href="https://www.rndsystems.com/target/pkc-beta-1">PKC beta 1</a><br><a href="https://www.rndsystems.com/target/pkc-beta-2">PKC beta 2</a><br><a href="https://www.rndsystems.com/target/pkc-gamma">PKC gamma</a><br><a href="https://www.rndsystems.com/target/pkc-epsilon">PKC epsilon</a><br><a href="https://www.rndsystems.com/target/pkc-delta">PKC delta</a><br><a href="https://www.rndsystems.com/target/pkc-iota-lambda">PKC iota/lambda</a><br><a href="https://www.rndsystems.com/target/pkc-iota-lambda-zeta">PKC iota/lambda/zeta</a><br><a href="https://www.rndsystems.com/target/pkc-theta">PKC theta</a><br><a href="https://www.rndsystems.com/target/pkc-zeta">PKC zeta</a><br> </div> </div> <div id="el49_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray49 pw-gray" style="top:363.66668701171875px;left:16.33331298828125px;"> PKC </div> <div id="el49_off" data-id="49" data-set="PKC25" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off49" style="top:363.66668701171875px;left:16.33331298828125px;"> PKC</div> <div id="el49_ct" class="pw-tooltip" data-id="49"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pkc-alpha">PKC alpha</a><br><a href="https://www.rndsystems.com/target/pkc-beta-1">PKC beta 1</a><br><a href="https://www.rndsystems.com/target/pkc-beta-2">PKC beta 2</a><br><a href="https://www.rndsystems.com/target/pkc-gamma">PKC gamma</a><br><a href="https://www.rndsystems.com/target/pkc-epsilon">PKC epsilon</a><br><a href="https://www.rndsystems.com/target/pkc-delta">PKC delta</a><br><a href="https://www.rndsystems.com/target/pkc-iota-lambda">PKC iota/lambda</a><br><a href="https://www.rndsystems.com/target/pkc-iota-lambda-zeta">PKC iota/lambda/zeta</a><br><a href="https://www.rndsystems.com/target/pkc-theta">PKC theta</a><br><a href="https://www.rndsystems.com/target/pkc-zeta">PKC zeta</a><br> </div> </div> <div id="el50_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray50 pw-gray" style="top:815.6666870117188px;left:129.33331298828125px;"> IP3 Receptor </div> <div id="el50_off" data-id="50" data-set="IP3Receptor26" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off50" style="top:815.6666870117188px;left:129.33331298828125px;"> IP3 Receptor</div> <div id="el50_ct" class="pw-tooltip" data-id="50"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ip3-receptor-inhibitors">IP3 Receptor</a><br> </div> </div> <div id="el51_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray51 pw-gray" style="top:772.6666870117188px;left:113.33331298828125px;"> Ca2+ </div> <div id="el51_off" data-id="51" data-set="Ca2plus" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off51" style="top:772.6666870117188px;left:113.33331298828125px;"> Ca2+</div> <div id="el51_ct" class="pw-tooltip" data-id="51"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el52_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray52 pw-gray" style="top:700.6666717529297px;left:115.33331298828125px;"> </div> <div id="el52_off" data-id="52" data-set="Calmodulin28" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off52" style="top:700.6666717529297px;left:115.33331298828125px;"> </div> <div id="el52_ct" class="pw-tooltip" data-id="52"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/calmodulin-1">Calmodulin</a><br> </div> </div> <div id="el53_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray53 pw-gray" style="top:685.6666870117188px;left:81.33331298828125px;"> Calmodulin </div> <div id="el53_off" data-id="53" data-set="Calmodulin28" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off53" style="top:685.6666870117188px;left:81.33331298828125px;"> Calmodulin</div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/calmodulin-1">Calmodulin</a><br> </div> </div> <div id="el54_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray54 pw-gray" style="top:701.6666870117188px;left:129.33331298828125px;"> </div> <div id="el54_off" data-id="54" data-set="CalcineurinPhosphatase29" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off54" style="top:701.6666870117188px;left:129.33331298828125px;"> </div> <div id="el54_ct" class="pw-tooltip" data-id="54"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/calcineurin">Calcineurin</a><br><a href="https://www.rndsystems.com/target/calcineurin-a">Calcineurin A</a><br><a href="https://www.rndsystems.com/target/calcineurin-b">Calcineurin B</a><br> </div> </div> <div id="el55_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray55 pw-gray" style="top:679.6666870117188px;left:162.33331298828125px;"> Calcineurin<br>Phosphatase </div> <div id="el55_off" data-id="55" data-set="CalcineurinPhosphatase29" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off55" style="top:679.6666870117188px;left:162.33331298828125px;"> Calcineurin<br>Phosphatase</div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/calcineurin">Calcineurin</a><br><a href="https://www.rndsystems.com/target/calcineurin-a">Calcineurin A</a><br><a href="https://www.rndsystems.com/target/calcineurin-b">Calcineurin B</a><br> </div> </div> <div id="el56_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray56 pw-gray" style="top:747.6666870117188px;left:193.33331298828125px;"> </div> <div id="el56_off" data-id="56" data-set="NFATC30" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off56" style="top:747.6666870117188px;left:193.33331298828125px;"> </div> <div id="el56_ct" class="pw-tooltip" data-id="56"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nfatc1">NFATC1</a><br><a href="https://www.rndsystems.com/target/nfatc2">NFATC2</a><br><a href="https://www.rndsystems.com/target/nfatc3">NFATC3</a><br><a href="https://www.rndsystems.com/search?keywords=nfat*">All NFAT Products</a><br> </div> </div> <div id="el57_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray57 pw-gray" style="top:762.6666870117188px;left:220.33331298828125px;"> NFATC </div> <div id="el57_off" data-id="57" data-set="NFATC30" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off57" style="top:762.6666870117188px;left:220.33331298828125px;"> NFATC</div> <div id="el57_ct" class="pw-tooltip" data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nfatc1">NFATC1</a><br><a href="https://www.rndsystems.com/target/nfatc2">NFATC2</a><br><a href="https://www.rndsystems.com/target/nfatc3">NFATC3</a><br><a href="https://www.rndsystems.com/search?keywords=nfat*">All NFAT Products</a><br> </div> </div> <div id="el58_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray58 pw-gray" style="top:875.6666870117188px;left:90.33331298828125px;"> </div> <div id="el58_off" data-id="58" data-set="NFATC31" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off58" style="top:875.6666870117188px;left:90.33331298828125px;"> </div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nfatc1">NFATC1</a><br><a href="https://www.rndsystems.com/target/nfatc2">NFATC2</a><br><a href="https://www.rndsystems.com/target/nfatc3">NFATC3</a><br><a href="https://www.rndsystems.com/search?keywords=nfat*">All NFAT Products</a><br> </div> </div> <div id="el59_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray59 pw-gray" style="top:862.6666870117188px;left:81.33331298828125px;"> NFATC </div> <div id="el59_off" data-id="59" data-set="NFATC31" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off59" style="top:862.6666870117188px;left:81.33331298828125px;"> NFATC</div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nfatc1">NFATC1</a><br><a href="https://www.rndsystems.com/target/nfatc2">NFATC2</a><br><a href="https://www.rndsystems.com/target/nfatc3">NFATC3</a><br><a href="https://www.rndsystems.com/search?keywords=nfat*">All NFAT Products</a><br> </div> </div> <div id="el60_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray60 pw-gray" style="top:931.6666870117188px;left:62.33331298828125px;"> Cell Motility </div> <div id="el60_off" data-id="60" data-set="CellMotility" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off60" style="top:931.6666870117188px;left:62.33331298828125px;"> Cell Motility</div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el61_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray61 pw-gray" style="top:303.66668701171875px;left:354.33331298828125px;"> </div> <div id="el61_off" data-id="61" data-set="PI3-K33" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off61" style="top:303.66668701171875px;left:354.33331298828125px;"> </div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pi-3-kinase-p55-gamma">PI 3-kinase p55 gamma</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p85-alpha">PI 3-Kinase p85 alpha</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p85-beta">PI 3-Kinase p85 beta</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a href="https://www.rndsystems.com/search?keywords=pi3k">All PI 3-K Products</a><br> </div> </div> <div id="el62_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray62 pw-gray" style="top:326.66668701171875px;left:351.33331298828125px;"> PI 3-K </div> <div id="el62_off" data-id="62" data-set="PI3-K33" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off62" style="top:326.66668701171875px;left:351.33331298828125px;"> PI 3-K</div> <div id="el62_ct" class="pw-tooltip" data-id="62"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pi-3-kinase-p55-gamma">PI 3-kinase p55 gamma</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p85-alpha">PI 3-Kinase p85 alpha</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p85-beta">PI 3-Kinase p85 beta</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a href="https://www.rndsystems.com/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a href="https://www.rndsystems.com/search?keywords=pi3k">All PI 3-K Products</a><br> </div> </div> <div id="el63_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray63 pw-gray" style="top:372.66668701171875px;left:322.33331298828125px;"> </div> <div id="el63_off" data-id="63" data-set="PIP234" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off63" style="top:372.66668701171875px;left:322.33331298828125px;"> </div> <div id="el63_ct" class="pw-tooltip" data-id="63"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIP2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el64_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray64 pw-gray" style="top:379.66668701171875px;left:297.33331298828125px;"> PIP2 </div> <div id="el64_off" data-id="64" data-set="PIP234" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off64" style="top:379.66668701171875px;left:297.33331298828125px;"> PIP2</div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIP2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el65_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray65 pw-gray" style="top:369.66668701171875px;left:369.33331298828125px;"> </div> <div id="el65_off" data-id="65" data-set="PIP335" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off65" style="top:369.66668701171875px;left:369.33331298828125px;"> </div> <div id="el65_ct" class="pw-tooltip" data-id="65"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/inositol-lipid-antagonists">PIP3</a><br> </div> </div> <div id="el66_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray66 pw-gray" style="top:379.66668701171875px;left:400.33331298828125px;"> PIP3 </div> <div id="el66_off" data-id="66" data-set="PIP335" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off66" style="top:379.66668701171875px;left:400.33331298828125px;"> PIP3</div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/inositol-lipid-antagonists">PIP3</a><br> </div> </div> <div id="el67_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray67 pw-gray" style="top:422.66668701171875px;left:344.33331298828125px;"> </div> <div id="el67_off" data-id="67" data-set="PDK-136" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off67" style="top:422.66668701171875px;left:344.33331298828125px;"> </div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pdk-1">PDK-1</a><br> </div> </div> <div id="el68_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray68 pw-gray" style="top:431.66668701171875px;left:307.33331298828125px;"> PDK-1 </div> <div id="el68_off" data-id="68" data-set="PDK-136" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off68" style="top:431.66668701171875px;left:307.33331298828125px;"> PDK-1</div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pdk-1">PDK-1</a><br> </div> </div> <div id="el69_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray69 pw-gray" style="top:488.66668701171875px;left:331.33331298828125px;"> </div> <div id="el69_off" data-id="69" data-set="AktPKB37" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off69" style="top:488.66668701171875px;left:331.33331298828125px;"> </div> <div id="el69_ct" class="pw-tooltip" data-id="69"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/akt">Akt</a><br><a href="https://www.rndsystems.com/target/akt1">Akt1</a><br><a href="https://www.rndsystems.com/target/akt2">Akt2</a><br><a href="https://www.rndsystems.com/target/akt3">Akt3</a><br> </div> </div> <div id="el70_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray70 pw-gray" style="top:475.66668701171875px;left:316.33331298828125px;"> Akt/PKB </div> <div id="el70_off" data-id="70" data-set="AktPKB37" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off70" style="top:475.66668701171875px;left:316.33331298828125px;"> Akt/PKB</div> <div id="el70_ct" class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/akt">Akt</a><br><a href="https://www.rndsystems.com/target/akt1">Akt1</a><br><a href="https://www.rndsystems.com/target/akt2">Akt2</a><br><a href="https://www.rndsystems.com/target/akt3">Akt3</a><br> </div> </div> <div id="el71_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray71 pw-gray" style="top:465.66668701171875px;left:268.33331298828125px;"> </div> <div id="el71_off" data-id="71" data-set="GSK-3beta-Inactive-38" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off71" style="top:465.66668701171875px;left:268.33331298828125px;"> </div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/gsk-3-beta">GSK-3 beta</a><br> </div> </div> <div id="el72_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray72 pw-gray" style="top:458.66668701171875px;left:201.33331298828125px;"> GSK-3 beta<br>(Inactive) </div> <div id="el72_off" data-id="72" data-set="GSK-3beta-Inactive-38" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off72" style="top:458.66668701171875px;left:201.33331298828125px;"> GSK-3 beta<br>(Inactive)</div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/gsk-3-beta">GSK-3 beta</a><br> </div> </div> <div id="el73_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray73 pw-gray" style="top:499.66668701171875px;left:251.33331298828125px;"> </div> <div id="el73_off" data-id="73" data-set="Bad-Inactive-39" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off73" style="top:499.66668701171875px;left:251.33331298828125px;"> </div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/bad">Bad</a><br> </div> </div> <div id="el74_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray74 pw-gray" style="top:507.66668701171875px;left:223.33331298828125px;"> Bad<br>(Inactive) </div> <div id="el74_off" data-id="74" data-set="Bad-Inactive-39" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off74" style="top:507.66668701171875px;left:223.33331298828125px;"> Bad<br>(Inactive)</div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/bad">Bad</a><br> </div> </div> <div id="el75_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray75 pw-gray" style="top:520.6666870117188px;left:286.33331298828125px;"> </div> <div id="el75_off" data-id="75" data-set="Caspase-9-Inactive-40" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off75" style="top:520.6666870117188px;left:286.33331298828125px;"> </div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/caspase-9">Caspase-9</a><br> </div> </div> <div id="el76_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray76 pw-gray" style="top:551.6666870117188px;left:247.33331298828125px;"> Caspase-9<br>(Inactive) </div> <div id="el76_off" data-id="76" data-set="Caspase-9-Inactive-40" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off76" style="top:551.6666870117188px;left:247.33331298828125px;"> Caspase-9<br>(Inactive)</div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/caspase-9">Caspase-9</a><br> </div> </div> <div id="el77_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray77 pw-gray" style="top:593px;left:163px;"> Anti-Apoptotic Signal </div> <div id="el77_off" data-id="77" data-set="Anti-ApoptoticSignal" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off77" style="top:593px;left:163px;"> Anti-Apoptotic Signal</div> <div id="el77_ct" class="pw-tooltip" data-id="77"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el78_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray78 pw-gray" style="top:690.6666870117188px;left:295.33331298828125px;"> </div> <div id="el78_off" data-id="78" data-set="FoxO42" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off78" style="top:690.6666870117188px;left:295.33331298828125px;"> </div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/foxo1-fkhr">FoxO1</a><br><a href="https://www.rndsystems.com/target/foxo3">FoxO3</a><br> </div> </div> <div id="el79_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray79 pw-gray" style="top:711.6666870117188px;left:291.33331298828125px;"> FoxO </div> <div id="el79_off" data-id="79" data-set="FoxO42" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off79" style="top:711.6666870117188px;left:291.33331298828125px;"> FoxO</div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/foxo1-fkhr">FoxO1</a><br><a href="https://www.rndsystems.com/target/foxo3">FoxO3</a><br> </div> </div> <div id="el80_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray80 pw-gray" style="top:873.6666870117188px;left:211.33331298828125px;"> </div> <div id="el80_off" data-id="80" data-set="FoxO43" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off80" style="top:873.6666870117188px;left:211.33331298828125px;"> </div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/foxo1-fkhr">FoxO1</a><br><a href="https://www.rndsystems.com/target/foxo3">FoxO3</a><br> </div> </div> <div id="el81_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray81 pw-gray" style="top:856.6666870117188px;left:208.33331298828125px;"> FoxO </div> <div id="el81_off" data-id="81" data-set="FoxO43" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off81" style="top:856.6666870117188px;left:208.33331298828125px;"> FoxO</div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/foxo1-fkhr">FoxO1</a><br><a href="https://www.rndsystems.com/target/foxo3">FoxO3</a><br> </div> </div> <div id="el82_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray82 pw-gray" style="top:931.6666870117188px;left:190.33331298828125px;"> Cell Survival </div> <div id="el82_off" data-id="82" data-set="CellSurvival" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off82" style="top:931.6666870117188px;left:190.33331298828125px;"> Cell Survival </div> <div id="el82_ct" class="pw-tooltip" data-id="82"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el83_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray83 pw-gray" style="top:496.66668701171875px;left:409.33331298828125px;"> </div> <div id="el83_off" data-id="83" data-set="TSC12-Inactive-45" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off83" style="top:496.66668701171875px;left:409.33331298828125px;"> </div> <div id="el83_ct" class="pw-tooltip" data-id="83"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tsc1">TSC1</a><br><a href="https://www.rndsystems.com/target/tsc2">TSC2</a><br> </div> </div> <div id="el84_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray84 pw-gray" style="top:498.66668701171875px;left:441.33331298828125px;"> TSC1/2<br>(Inactive) </div> <div id="el84_off" data-id="84" data-set="TSC12-Inactive-45" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off84" style="top:498.66668701171875px;left:441.33331298828125px;"> TSC1/2<br>(Inactive)</div> <div id="el84_ct" class="pw-tooltip" data-id="84"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tsc1">TSC1</a><br><a href="https://www.rndsystems.com/target/tsc2">TSC2</a><br> </div> </div> <div id="el85_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray85 pw-gray" style="top:547.6666870117188px;left:397.33331298828125px;"> </div> <div id="el85_off" data-id="85" data-set="Rheb46" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off85" style="top:547.6666870117188px;left:397.33331298828125px;"> </div> <div id="el85_ct" class="pw-tooltip" data-id="85"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/rheb">Rheb</a><br> </div> </div> <div id="el86_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray86 pw-gray" style="top:555.6666870117188px;left:369.33331298828125px;"> Rheb </div> <div id="el86_off" data-id="86" data-set="Rheb46" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off86" style="top:555.6666870117188px;left:369.33331298828125px;"> Rheb</div> <div id="el86_ct" class="pw-tooltip" data-id="86"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/rheb">Rheb</a><br> </div> </div> <div id="el87_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray87 pw-gray" style="top:547.6666870117188px;left:413.33331298828125px;"> </div> <div id="el87_off" data-id="87" data-set="GTP47" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off87" style="top:547.6666870117188px;left:413.33331298828125px;"> </div> <div id="el87_ct" class="pw-tooltip" data-id="87"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GTP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el88_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray88 pw-gray" style="top:556.6666870117188px;left:440.33331298828125px;"> GTP </div> <div id="el88_off" data-id="88" data-set="GTP47" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off88" style="top:556.6666870117188px;left:440.33331298828125px;"> GTP</div> <div id="el88_ct" class="pw-tooltip" data-id="88"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GTP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el89_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray89 pw-gray" style="top:594.6666870117188px;left:405.33331298828125px;"> </div> <div id="el89_off" data-id="89" data-set="mTORC148" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off89" style="top:594.6666870117188px;left:405.33331298828125px;"> </div> <div id="el89_ct" class="pw-tooltip" data-id="89"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/deptor-depdc6">DEPTOR</a><br><a href="https://www.rndsystems.com/target/gbl">GBL</a><br><a href="https://www.rndsystems.com/target/tor">mTOR</a><br><a href="https://www.rndsystems.com/target/pras40">PRAS40</a><br><a href="https://www.rndsystems.com/target/rptor">RPTOR</a><br> </div> </div> <div id="el90_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray90 pw-gray" style="top:600.6666870117188px;left:434.33331298828125px;"> mTORC1 </div> <div id="el90_off" data-id="90" data-set="mTORC148" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off90" style="top:600.6666870117188px;left:434.33331298828125px;"> mTORC1</div> <div id="el90_ct" class="pw-tooltip" data-id="90"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/deptor-depdc6">DEPTOR</a><br><a href="https://www.rndsystems.com/target/gbl">GBL</a><br><a href="https://www.rndsystems.com/target/tor">mTOR</a><br><a href="https://www.rndsystems.com/target/pras40">PRAS40</a><br><a href="https://www.rndsystems.com/target/rptor">RPTOR</a><br> </div> </div> <div id="el91_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray91 pw-gray" style="top:628.6666870117188px;left:380.33331298828125px;"> </div> <div id="el91_off" data-id="91" data-set="p70S6K49" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off91" style="top:628.6666870117188px;left:380.33331298828125px;"> </div> <div id="el91_ct" class="pw-tooltip" data-id="91"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/p70-s6-kinase">p70 S6 Kinase</a><br><a href="https://www.rndsystems.com/target/p70-s6-kinase-beta">p70 S6 Kinase beta</a><br> </div> </div> <div id="el92_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray92 pw-gray" style="top:640.6666870117188px;left:332.33331298828125px;"> p70 S6K </div> <div id="el92_off" data-id="92" data-set="p70S6K49" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off92" style="top:640.6666870117188px;left:332.33331298828125px;"> p70 S6K</div> <div id="el92_ct" class="pw-tooltip" data-id="92"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/p70-s6-kinase">p70 S6 Kinase</a><br><a href="https://www.rndsystems.com/target/p70-s6-kinase-beta">p70 S6 Kinase beta</a><br> </div> </div> <div id="el93_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray93 pw-gray" style="top:669.6666870117188px;left:365.33331298828125px;"> </div> <div id="el93_off" data-id="93" data-set="RPS650" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off93" style="top:669.6666870117188px;left:365.33331298828125px;"> </div> <div id="el93_ct" class="pw-tooltip" data-id="93"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ribosomal-protein-s6-rps6">Ribosomal Protein S6</a><br> </div> </div> <div id="el94_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray94 pw-gray" style="top:693.6666870117188px;left:362.33331298828125px;"> RPS6 </div> <div id="el94_off" data-id="94" data-set="RPS650" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off94" style="top:693.6666870117188px;left:362.33331298828125px;"> RPS6</div> <div id="el94_ct" class="pw-tooltip" data-id="94"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ribosomal-protein-s6-rps6">Ribosomal Protein S6</a><br> </div> </div> <div id="el95_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray95 pw-gray" style="top:626.6666870117188px;left:445.33331298828125px;"> </div> <div id="el95_off" data-id="95" data-set="fourEBP151" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off95" style="top:626.6666870117188px;left:445.33331298828125px;"> </div> <div id="el95_ct" class="pw-tooltip" data-id="95"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el96_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray96 pw-gray" style="top:624.6666870117188px;left:469.33331298828125px;"> 4EBP1 </div> <div id="el96_off" data-id="96" data-set="fourEBP151" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off96" style="top:624.6666870117188px;left:469.33331298828125px;"> 4EBP1</div> <div id="el96_ct" class="pw-tooltip" data-id="96"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el97_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray97 pw-gray" style="top:643.6666870117188px;left:446.33331298828125px;"> </div> <div id="el97_off" data-id="97" data-set="eIF4E52" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off97" style="top:643.6666870117188px;left:446.33331298828125px;"> </div> <div id="el97_ct" class="pw-tooltip" data-id="97"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/eif4e">eIF4E</a><br> </div> </div> <div id="el98_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray98 pw-gray" style="top:650.6666870117188px;left:479.33331298828125px;"> eIF4E </div> <div id="el98_off" data-id="98" data-set="eIF4E52" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off98" style="top:650.6666870117188px;left:479.33331298828125px;"> eIF4E</div> <div id="el98_ct" class="pw-tooltip" data-id="98"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/eif4e">eIF4E</a><br> </div> </div> <div id="el99_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray99 pw-gray" style="top:680.6666870117188px;left:429.33331298828125px;"> </div> <div id="el99_off" data-id="99" data-set="eIF4E53" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off99" style="top:680.6666870117188px;left:429.33331298828125px;"> </div> <div id="el99_ct" class="pw-tooltip" data-id="99"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/eif4e">eIF4E</a><br> </div> </div> <div id="el100_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray100 pw-gray" style="top:706.6666870117188px;left:425.33331298828125px;"> eIF4E </div> <div id="el100_off" data-id="100" data-set="eIF4E53" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off100" style="top:706.6666870117188px;left:425.33331298828125px;"> eIF4E</div> <div id="el100_ct" class="pw-tooltip" data-id="100"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/eif4e">eIF4E</a><br> </div> </div> <div id="el101_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray101 pw-gray" style="top:677.6666870117188px;left:470.33331298828125px;"> </div> <div id="el101_off" data-id="101" data-set="fourEBP154" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off101" style="top:677.6666870117188px;left:470.33331298828125px;"> </div> <div id="el101_ct" class="pw-tooltip" data-id="101"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el102_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray102 pw-gray" style="top:706.6666870117188px;left:470.33331298828125px;"> 4EBP1 </div> <div id="el102_off" data-id="102" data-set="fourEBP154" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off102" style="top:706.6666870117188px;left:470.33331298828125px;"> 4EBP1</div> <div id="el102_ct" class="pw-tooltip" data-id="102"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el103_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray103 pw-gray" style="top:731px;left:395px;"> Protein Synthesis </div> <div id="el103_off" data-id="103" data-set="ProteinSynthesis" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off103" style="top:731px;left:395px;"> Protein Synthesis</div> <div id="el103_ct" class="pw-tooltip" data-id="103"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el104_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray104 pw-gray" style="top:348.66668701171875px;left:445.33331298828125px;"> </div> <div id="el104_off" data-id="104" data-set="Jak56" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off104" style="top:348.66668701171875px;left:445.33331298828125px;"> </div> <div id="el104_ct" class="pw-tooltip" data-id="104"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/jak1">Jak1</a><br><a href="https://www.rndsystems.com/target/jak2">Jak2</a><br><a href="https://www.rndsystems.com/target/jak3">Jak3</a><br><a href="https://www.rndsystems.com/target/tyk2">Tyk2</a><br> </div> </div> <div id="el105_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray105 pw-gray" style="top:358.66668701171875px;left:470.33331298828125px;"> Jak </div> <div id="el105_off" data-id="105" data-set="Jak56" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off105" style="top:358.66668701171875px;left:470.33331298828125px;"> Jak</div> <div id="el105_ct" class="pw-tooltip" data-id="105"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/jak1">Jak1</a><br><a href="https://www.rndsystems.com/target/jak2">Jak2</a><br><a href="https://www.rndsystems.com/target/jak3">Jak3</a><br><a href="https://www.rndsystems.com/target/tyk2">Tyk2</a><br> </div> </div> <div id="el106_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray106 pw-gray" style="top:389.66668701171875px;left:484.33331298828125px;"> </div> <div id="el106_off" data-id="106" data-set="STAT57" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off106" style="top:389.66668701171875px;left:484.33331298828125px;"> </div> <div id="el106_ct" class="pw-tooltip" data-id="106"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/stat1">STAT1</a><br><a href="https://www.rndsystems.com/target/stat3">STAT3</a><br><a href="https://www.rndsystems.com/target/stat5a">STAT5a</a><br><a href="https://www.rndsystems.com/target/stat5a-b">STAT5a/b</a><br><a href="https://www.rndsystems.com/target/stat5b">STAT5b</a><br> </div> </div> <div id="el107_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray107 pw-gray" style="top:397.66668701171875px;left:510.33331298828125px;"> STAT </div> <div id="el107_off" data-id="107" data-set="STAT57" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off107" style="top:397.66668701171875px;left:510.33331298828125px;"> STAT</div> <div id="el107_ct" class="pw-tooltip" data-id="107"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/stat1">STAT1</a><br><a href="https://www.rndsystems.com/target/stat3">STAT3</a><br><a href="https://www.rndsystems.com/target/stat5a">STAT5a</a><br><a href="https://www.rndsystems.com/target/stat5a-b">STAT5a/b</a><br><a href="https://www.rndsystems.com/target/stat5b">STAT5b</a><br> </div> </div> <div id="el108_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray108 pw-gray" style="top:442.66668701171875px;left:495.33331298828125px;"> </div> <div id="el108_off" data-id="108" data-set="STATDimer58" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off108" style="top:442.66668701171875px;left:495.33331298828125px;"> </div> <div id="el108_ct" class="pw-tooltip" data-id="108"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/stat1">STAT1</a><br><a href="https://www.rndsystems.com/target/stat3">STAT3</a><br><a href="https://www.rndsystems.com/target/stat5a">STAT5a</a><br><a href="https://www.rndsystems.com/target/stat5a-b">STAT5a/b</a><br><a href="https://www.rndsystems.com/target/stat5b">STAT5b</a><br> </div> </div> <div id="el109_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray109 pw-gray" style="top:471.66668701171875px;left:490.33331298828125px;"> STAT Dimer </div> <div id="el109_off" data-id="109" data-set="STATDimer58" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off109" style="top:471.66668701171875px;left:490.33331298828125px;"> STAT Dimer</div> <div id="el109_ct" class="pw-tooltip" data-id="109"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/stat1">STAT1</a><br><a href="https://www.rndsystems.com/target/stat3">STAT3</a><br><a href="https://www.rndsystems.com/target/stat5a">STAT5a</a><br><a href="https://www.rndsystems.com/target/stat5a-b">STAT5a/b</a><br><a href="https://www.rndsystems.com/target/stat5b">STAT5b</a><br> </div> </div> <div id="el110_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray110 pw-gray" style="top:873.6666870117188px;left:328.33331298828125px;"> </div> <div id="el110_off" data-id="110" data-set="STATDimer59" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off110" style="top:873.6666870117188px;left:328.33331298828125px;"> </div> <div id="el110_ct" class="pw-tooltip" data-id="110"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/stat1">STAT1</a><br><a href="https://www.rndsystems.com/target/stat3">STAT3</a><br><a href="https://www.rndsystems.com/target/stat5a">STAT5a</a><br><a href="https://www.rndsystems.com/target/stat5a-b">STAT5a/b</a><br><a href="https://www.rndsystems.com/target/stat5b">STAT5b</a><br> </div> </div> <div id="el111_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray111 pw-gray" style="top:857.6666870117188px;left:323.33331298828125px;"> STAT Dimer </div> <div id="el111_off" data-id="111" data-set="STATDimer59" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off111" style="top:857.6666870117188px;left:323.33331298828125px;"> STAT Dimer</div> <div id="el111_ct" class="pw-tooltip" data-id="111"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/stat1">STAT1</a><br><a href="https://www.rndsystems.com/target/stat3">STAT3</a><br><a href="https://www.rndsystems.com/target/stat5a">STAT5a</a><br><a href="https://www.rndsystems.com/target/stat5a-b">STAT5a/b</a><br><a href="https://www.rndsystems.com/target/stat5b">STAT5b</a><br> </div> </div> <div id="el112_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 pw-center el-gray112 pw-gray" style="top:930px;left:299.33331298828125px;"> Cell Proliferation<br>Differentiation </div> <div id="el112_off" data-id="112" data-set="CellProliferation" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 pw-center el-off112" style="top:930px;left:299.33331298828125px;"> Cell Proliferation<br>Differentiation</div> <div id="el112_ct" class="pw-tooltip" data-id="112"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el113_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray113 pw-gray" style="top:354.66668701171875px;left:595.3333129882812px;"> </div> <div id="el113_off" data-id="113" data-set="Ras61" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off113" style="top:354.66668701171875px;left:595.3333129882812px;"> </div> <div id="el113_ct" class="pw-tooltip" data-id="113"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ras">Ras</a><br> </div> </div> <div id="el114_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray114 pw-gray" style="top:373.66668701171875px;left:585.3333129882812px;"> Ras </div> <div id="el114_off" data-id="114" data-set="Ras61" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off114" style="top:373.66668701171875px;left:585.3333129882812px;"> Ras</div> <div id="el114_ct" class="pw-tooltip" data-id="114"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ras">Ras</a><br> </div> </div> <div id="el115_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray115 pw-gray" style="top:341.66668701171875px;left:584.3333129882812px;"> </div> <div id="el115_off" data-id="115" data-set="GDP62" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off115" style="top:341.66668701171875px;left:584.3333129882812px;"> </div> <div id="el115_ct" class="pw-tooltip" data-id="115"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GDP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el116_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray116 pw-gray" style="top:349.66668701171875px;left:562.3333129882812px;"> GDP </div> <div id="el116_off" data-id="116" data-set="GDP62" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off116" style="top:349.66668701171875px;left:562.3333129882812px;"> GDP</div> <div id="el116_ct" class="pw-tooltip" data-id="116"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GDP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el117_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray117 pw-gray" style="top:354.66668701171875px;left:642.6666564941406px;"> </div> <div id="el117_off" data-id="117" data-set="Ras63" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off117" style="top:354.66668701171875px;left:642.6666564941406px;"> </div> <div id="el117_ct" class="pw-tooltip" data-id="117"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ras">Ras</a><br> </div> </div> <div id="el118_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray118 pw-gray" style="top:377.66668701171875px;left:667.3334045410156px;"> Ras </div> <div id="el118_off" data-id="118" data-set="Ras63" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off118" style="top:377.66668701171875px;left:667.3334045410156px;"> Ras</div> <div id="el118_ct" class="pw-tooltip" data-id="118"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ras">Ras</a><br> </div> </div> <div id="el119_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray119 pw-gray" style="top:344.66668701171875px;left:655.3334045410156px;"> </div> <div id="el119_off" data-id="119" data-set="GTP64" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off119" style="top:344.66668701171875px;left:655.3334045410156px;"> </div> <div id="el119_ct" class="pw-tooltip" data-id="119"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GTP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el120_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray120 pw-gray" style="top:349.66668701171875px;left:682px;"> GTP </div> <div id="el120_off" data-id="120" data-set="GTP64" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off120" style="top:349.66668701171875px;left:682px;"> GTP</div> <div id="el120_ct" class="pw-tooltip" data-id="120"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GTP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el121_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray121 pw-gray" style="top:425.66668701171875px;left:629.3334045410156px;"> </div> <div id="el121_off" data-id="121" data-set="Rac65" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off121" style="top:425.66668701171875px;left:629.3334045410156px;"> </div> <div id="el121_ct" class="pw-tooltip" data-id="121"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/rac1">Rac1</a><br> </div> </div> <div id="el122_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray122 pw-gray" style="top:433.66668701171875px;left:607.3334045410156px;"> Rac </div> <div id="el122_off" data-id="122" data-set="Rac65" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off122" style="top:433.66668701171875px;left:607.3334045410156px;"> Rac</div> <div id="el122_ct" class="pw-tooltip" data-id="122"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/rac1">Rac1</a><br> </div> </div> <div id="el123_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray123 pw-gray" style="top:474.66668701171875px;left:581.3334045410156px;"> </div> <div id="el123_off" data-id="123" data-set="p3866" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off123" style="top:474.66668701171875px;left:581.3334045410156px;"> </div> <div id="el123_ct" class="pw-tooltip" data-id="123"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/p38">p38</a><br><a href="https://www.rndsystems.com/target/p38-alpha">p38 alpha</a><br><a href="https://www.rndsystems.com/target/p38-beta-mapk11">p38 beta</a><br><a href="https://www.rndsystems.com/target/p38-gamma">p38 gamma</a><br><a href="https://www.rndsystems.com/target/p38-delta">p38 delta</a><br> </div> </div> <div id="el124_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray124 pw-gray" style="top:500.66668701171875px;left:573.3334045410156px;"> p38 </div> <div id="el124_off" data-id="124" data-set="p3866" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off124" style="top:500.66668701171875px;left:573.3334045410156px;"> p38</div> <div id="el124_ct" class="pw-tooltip" data-id="124"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/p38">p38</a><br><a href="https://www.rndsystems.com/target/p38-alpha">p38 alpha</a><br><a href="https://www.rndsystems.com/target/p38-beta-mapk11">p38 beta</a><br><a href="https://www.rndsystems.com/target/p38-gamma">p38 gamma</a><br><a href="https://www.rndsystems.com/target/p38-delta">p38 delta</a><br> </div> </div> <div id="el125_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray125 pw-gray" style="top:487.66668701171875px;left:621.3334045410156px;"> </div> <div id="el125_off" data-id="125" data-set="JNK67" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off125" style="top:487.66668701171875px;left:621.3334045410156px;"> </div> <div id="el125_ct" class="pw-tooltip" data-id="125"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/jnk">JNK</a><br> <a href="https://www.rndsystems.com/target/jnk1">JNK1</a><br> <a href="https://www.rndsystems.com/target/jnk1-jnk2">JNK1/JNK2</a><br> <a href="https://www.rndsystems.com/target/jnk2">JNK2</a><br> <a href="https://www.rndsystems.com/target/jnk3">JNK3</a><br> </div> </div> <div id="el126_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray126 pw-gray" style="top:515.6666870117188px;left:620.3334045410156px;"> JNK </div> <div id="el126_off" data-id="126" data-set="JNK67" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off126" style="top:515.6666870117188px;left:620.3334045410156px;"> JNK</div> <div id="el126_ct" class="pw-tooltip" data-id="126"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/jnk">JNK</a><br> <a href="https://www.rndsystems.com/target/jnk1">JNK1</a><br> <a href="https://www.rndsystems.com/target/jnk1-jnk2">JNK1/JNK2</a><br> <a href="https://www.rndsystems.com/target/jnk2">JNK2</a><br> <a href="https://www.rndsystems.com/target/jnk3">JNK3</a><br> </div> </div> <div id="el127_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray127 pw-gray" style="top:843.6666870117188px;left:452.3333435058594px;"> Transcription<br>Factor </div> <div id="el127_off" data-id="127" data-set="TranscriptionFactor" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off127" style="top:843.6666870117188px;left:452.3333435058594px;"> Transcription<br>Factor</div> <div id="el127_ct" class="pw-tooltip" data-id="127"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el128_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray128 pw-gray" style="top:931px;left:417.3333435058594px;"> Stress Response </div> <div id="el128_off" data-id="128" data-set="StressResponse" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off128" style="top:931px;left:417.3333435058594px;"> Stress Response</div> <div id="el128_ct" class="pw-tooltip" data-id="128"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el129_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray129 pw-gray" style="top:429.6666717529297px;left:673.3334045410156px;"> </div> <div id="el129_off" data-id="129" data-set="Raf70" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off129" style="top:429.6666717529297px;left:673.3334045410156px;"> </div> <div id="el129_ct" class="pw-tooltip" data-id="129"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/raf-1">Raf-1</a><br><a href="https://www.rndsystems.com/target/b-raf">B-Raf</a><br><a href="https://www.rndsystems.com/target/a-raf">A-Raf</a><br> </div> </div> <div id="el130_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray130 pw-gray" style="top:440.66668701171875px;left:700px;"> Raf </div> <div id="el130_off" data-id="130" data-set="Raf70" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off130" style="top:440.66668701171875px;left:700px;"> Raf</div> <div id="el130_ct" class="pw-tooltip" data-id="130"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/raf-1">Raf-1</a><br><a href="https://www.rndsystems.com/target/b-raf">B-Raf</a><br><a href="https://www.rndsystems.com/target/a-raf">A-Raf</a><br> </div> </div> <div id="el131_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray131 pw-gray" style="top:480.66668701171875px;left:672.3334045410156px;"> </div> <div id="el131_off" data-id="131" data-set="MEK1271" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off131" style="top:480.66668701171875px;left:672.3334045410156px;"> </div> <div id="el131_ct" class="pw-tooltip" data-id="131"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/mek1">MEK1</a><br> <a href="https://www.rndsystems.com/target/mek2">MEK2</a><br> <a href="https://www.rndsystems.com/target/mek1-mek2">MEK1/MEK2</a><br> <a href="https://www.rndsystems.com/target/mek-inhibitors">MEK Inhibitors</a><br> </div> </div> <div id="el132_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-gray132 pw-gray" style="top:489.66668701171875px;left:703.3334045410156px;"> MEK1/2 </div> <div id="el132_off" data-id="132" data-set="MEK1271" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label el-off132" style="top:489.66668701171875px;left:703.3334045410156px;"> MEK1/2</div> <div id="el132_ct" class="pw-tooltip" data-id="132"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/mek1">MEK1</a><br> <a href="https://www.rndsystems.com/target/mek2">MEK2</a><br> <a href="https://www.rndsystems.com/target/mek1-mek2">MEK1/MEK2</a><br> <a href="https://www.rndsystems.com/target/mek-inhibitors">MEK Inhibitors</a><br> </div> </div> <div id="el133_gry" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-gray133 pw-gray" style="top:528.6666870117188px;left:671.3334045410156px;"> </div> <div id="el133_off" data-id="133" data-set="ERK1272" data-type="No Products Click" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-sprite el-off133" 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fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-gray141 pw-gray" style="top:773px;left:676px;"> Negative Feedback </div> <div id="el141_off" data-id="141" data-set="NegativeFeedback" data-type="" class="fgfsignaling_all fgf_1 fgf_4 fgf_7 fgf_8 fgf_9 fgf_11 fgf_19 pw-label2 el-off141" style="top:773px;left:676px;"> Negative Feedback</div> <div id="el141_ct" class="pw-tooltip" data-id="141"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el142_off" data-id="142" data-set="fgfbox1" data-type="" class="fgf_1 pw-label2 pw-left pw-none el-off142" style="top:10px;left:15px;"> <table class=pw_table cellpadding=0 cellspacing=0 style="filter:alpha(opacity=100);opacity: 100;width:300"> <tr><td>• FGF-1 subfamily members: FGF-1 and FGF-2.</td></tr> <tr><td>• Both lack a classical secretory signal peptide and are secreted independently of the traditional ER-Golgi secretory pathway.</td></tr> <tr><td>• Utilize heparin/HS as a co-factor to bind to FGF receptors.</td></tr> <tr><td>• FGF-1 and FGF-2 are found in the nucleus of some cells.</td></tr> <tr><td>• See the table below the pathway for additional information on the FGF-1 subfamily members including their suggested physiological functions and reported receptor binding specificities.</td></tr> </table> </div> <div id="el142_ct" class="pw-tooltip" data-id="142"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el143_off" data-id="143" data-set="fgfbox" data-type="" class="fgf_4 pw-label2 pw-left pw-none el-off143" style="top:10px;left:15px;"> <table class=pw_table cellpadding=0 cellspacing=0 style="filter:alpha(opacity=0);opacity: 0;width:300"> <tr><td>• FGF-4 subfamily members: FGF-4, FGF-5, and FGF-6.</td></tr> <tr><td>• Have a cleavable N-terminal signal peptide.</td></tr> <tr><td>• Utilize heparin/HS as a co-factor to bind to FGF receptors.</td></tr> <tr><td>• See the table below the pathway for additional information on the FGF-4 subfamily members including their suggested physiological functions and reported receptor binding specificities.</td></tr> </table> </div> <div id="el143_ct" class="pw-tooltip" data-id="143"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el144_off" data-id="144" data-set="fgfbox" data-type="" class="fgf_7 pw-label2 pw-left pw-none el-off144" style="top:10px;left:15px;"> <table class=pw_table cellpadding=0 cellspacing=0 style="filter:alpha(opacity=0);opacity: 0;width:300"> <tr><td>• FGF-7 subfamily members: FGF-3, FGF-7, FGF-10, and FGF-22.</td></tr> <tr><td>• Utilize heparin/HS as a co-factor to bind to FGF receptors.</td></tr> <tr><td>• See the table below the pathway for additional information on the FGF-7 subfamily members including their suggested physiological functions and reported receptor binding specificities.</td></tr> </table> </div> <div id="el144_ct" class="pw-tooltip" data-id="144"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el145_off" data-id="145" data-set="fgfbox" data-type="" class="fgf_8 pw-label2 pw-left pw-none el-off145" style="top:10px;left:15px;"> <table class=pw_table cellpadding=0 cellspacing=0 style="filter:alpha(opacity=0);opacity: 0;width:300"> <tr><td>• FGF-8 subfamily members: FGF-8, FGF-17, and FGF-18.</td></tr> <tr><td>• Have a cleavable N-terminal signal peptide.</td></tr> <tr><td>• Utilize heparin/HS as a co-factor to bind to FGF receptors.</td></tr> <tr><td>• Alternative splicing of FGF8 gives rise to four potential isoforms in human (FGF-8a, FGF-8b, FGF-8e, FGF-8f) and eight in mouse (FGF-8a-h).</td></tr> <tr><td>• See the table below the pathway for additional information on the FGF-8 subfamily members including their suggested physiological functions and reported receptor binding specificities.</td></tr> </table> </div> <div 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data-id="146"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el147_off" data-id="147" data-set="fgfbox" data-type="" class="fgf_11 pw-label2 pw-left pw-none el-off147" style="top:10px;left:15px;"> <table class=pw_table cellpadding=0 cellspacing=0 style="filter:alpha(opacity=0);opacity: 0;width:300"> <tr><td>• FGF-11 subfamily members: FGF-11, FGF-12, FGF-13, and FGF-14.</td></tr> <tr><td>• Also known as FGF homologous factors (FHFs), FGF-11 subfamily members have high sequence identity and structural homology with the FGF family, but are not secreted and do not activate FGF receptors.</td></tr> <tr><td>• As intracellular FGFs, FGF-11 subfamily members interact with the cytosolic carboxy-terminal tail of voltage-gated sodium channels.</td></tr> <tr><td>• See the table below the pathway for additional information on the FGF-11 subfamily members including their suggested physiological functions and reported receptor binding specificities.</td></tr> </table> </div> <div id="el147_ct" class="pw-tooltip" data-id="147"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el148_off" data-id="148" data-set="fgfbox" data-type="" class="fgf_19 pw-label2 pw-left pw-none el-off148" style="top:10px;left:15px;"> <table class=pw_table cellpadding=0 cellspacing=0 style="filter:alpha(opacity=0);opacity: 0;width:300"><tr><td>• FGF-19 subfamily members: FGF-19 (human)/FGF-15 (mouse), FGF-21, and FGF-23.</td></tr><tr><td>• Bind to heparin/HS with very low affinity, facilitating their release from the ECM and their function as endocrine factors.</td></tr><tr><td>• Require Klotho proteins as co-factors to bind to FGF receptors.</td></tr><tr><td>• FGF-15 is the mouse orthologue of human FGF-19.</td></tr><tr><td>• See the table below the pathway for additional information on the FGF-19 subfamily members including their suggested physiological functions and reported receptor binding specificities.</td></tr></table> </div> <div id="el148_ct" class="pw-tooltip" data-id="148"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/fgfsignaling_static.png?t=1" alt="FGF Family Signaling Pathways" style="height:997px"> </div> </div> <div id="pathway-description"><h2>Overview of Fibroblast Growth Factor (FGF) Family Signaling Pathways</h2><p><p>The mammalian Fibroblast Growth Factor (FGF) superfamily consists of eighteen secreted <a href="/products/proteins">proteins</a> (FGF-1 – FGF-10 and FGF-16 – FGF-23) and four intracellular FGFs (FGF-11 – FGF-14), known as FGF homologous factors. The secreted FGFs belong to one of six subfamilies (FGF-1, FGF-4, FGF-7, FGF-8, FGF-9, and FGF-19) based on sequence homology, biological functions, and evolutionary relationships, while the intracellular FGFs make up the FGF-11 subfamily. Secreted FGFs are typically sequestered by heparan sulfate <a href="/research-area/proteoglycans">proteoglycans</a> (HSPGs) that are tethered to the cell surface and/or associated with the extracellular matrix, causing their effects to be localized to nearby cells. Only the FGF-19 subfamily, including FGF-21, FGF-23, and FGF-19 in humans or the mouse FGF-19 equivalent, FGF-15, acts in an <a href="/research-area/endocrinology">endocrine</a> manner. Although these FGFs are also dependent on HSPGs for signaling, they bind to heparin/heparan sulfate (HS) with very low affinity compared to the other FGFs, allowing them to more freely circulate. Unlike the canonical, secreted FGFs, intracellular FGFs (iFGFs) are nonsignaling proteins that interact with the cytosolic carboxy-terminal tail of voltage-gated sodium (NaV) channels. This group of FGFs have been shown to regulate <a href="https://www.bio-techne.com/research/neuroscience">neuronal</a> and <a href="https://www.bio-techne.com/research/cardiovascular-biology">myocardial</a> excitability by modulating both the current density and gating properties of Na<sub>V</sub> channels.</p> <p>Secreted FGFs bind to one of four transmembrane receptors with intracellular tyrosine kinase domains (FGF R1, FGF R2, FGF R3, and FGF R4) in a 2:2:2 HSPG-FGF-FGF receptor ratio. Ligand binding specificity is determined by the differential expression patterns of the FGFs, FGF receptors, and glycosaminoglycan structures, different receptor binding capacities, the requirement for specific co-factors such as the Klotho family proteins, and alternative splicing of the FGF receptors that results in two different versions of the extracellular Ig-like domain III (b or c). Following HSPG-ligand-binding to the FGF receptor, the receptor homodimerizes, leading to activation of the cytoplasmic intracellular kinase domain of the receptor, and recruitment and docking of adaptor proteins such as FRS2, GRB2, Shb, and Shc. These adaptor proteins subsequently activate multiple downstream <a href="/research-area/signal-transduction">signaling</a> pathways including the Ras-MAPK pathway, the Jak-STAT pathway, the PI 3-Kinase-Akt pathway, the PLC gamma pathway, and the p38 and JNK MAPK pathways. Through these signaling pathways, FGFs promote fundamental cellular processes such as survival, proliferation, differentiation, and motility. Secreted FGFs have been shown to be involved in a wide range of biological processes during normal physiological development including cell differentiation in the early embryo, pattern formation, branching morphogenesis, limb development, and organogenesis, including heart and brain development. Additionally, they contribute to the maintenance of tissue homeostasis, repair, and <a href="https://www.bio-techne.com/research/metabolism" target="_blank">metabolism</a> in adult organisms. Gain or loss of function mutations in FGFs are associated with a variety of developmental defects and pathological conditions including <a href="https://www.bio-techne.com/research/cancer-profiling" target="_blank">cancer</a>.</p> <p>To learn more, please visit our <a href="/research-area/fgf-family">FGF Family Research Area</a> page</p> <table cellpadding="1" cellspacing="1" class="border" width="100%"> <tbody> <tr> <td class="blue_high" rowspan="2">Subfamily</td> <td class="blue_high" rowspan="2">Human Ligands</td> <td class="blue_high" rowspan="2" width="15%">Alternate Name</td> <td class="blue_high" rowspan="2">Physiological Function (Based on the knockout mouse phenotype)</td> <td class="blue_high" rowspan="2">Pathologies Associated with FGF Mutations</td> <td class="blue_high" colspan="7">Reported Receptor Binding Specificity</td> </tr> <tr style="background-color: #595A5A";> <td style="color: #FFFFFF">R1b</td> <td style="color: #FFFFFF">R1c</td> <td style="color: #FFFFFF">R2b</td> <td style="color: #FFFFFF">R2c</td> <td style="color: #FFFFFF">R3b</td> <td style="color: #FFFFFF">R3c</td> <td style="color: #FFFFFF">R4</td> </tr> <tr> <td rowspan="2">FGF-1</td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-1&numResults=25">FGF-1</a></td> <td>FGF acidic; HBGF-1</td> <td>Not established</td> <td>• FGF1 amplification - ovarian cancer</td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-2&numResults=50">FGF-2</a></td> <td>FGF basic; HBGF-2</td> <td>Wound healing</td> <td>• FGF2 overexpression - bladder cancer, prostate cancer, small cell lung carcinoma, hepatocellular carcinoma, melanoma</td> <td>X</td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td class="blue_high" rowspan="2">Subfamily</td> <td class="blue_high" rowspan="2">Human Ligands</td> <td class="blue_high" rowspan="2" width="15%">Alternate Name</td> <td class="blue_high" rowspan="2">Physiological Function (Based on the knockout mouse phenotype)</td> <td class="blue_high" rowspan="2">Pathologies Associated with FGF Mutations</td> <td class="blue_high" colspan="7">Reported Receptor Binding Specificity</td> </tr> <tr style="background-color: #595A5A";> <td style="color: #FFFFFF">R1b</td> <td style="color: #FFFFFF">R1c</td> <td style="color: #FFFFFF">R2b</td> <td style="color: #FFFFFF">R2c</td> <td style="color: #FFFFFF">R3b</td> <td style="color: #FFFFFF">R3c</td> <td style="color: #FFFFFF">R4</td> </tr> <tr> <td rowspan="3">FGF-4</td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-4&numResults=25">FGF-4</a></td> <td>K-FGF; HBGF-4; HST-1</td> <td>Limb bud and<br /> heart development</td> <td>• FGF4 amplication - breast cancer</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-5">FGF-5</a></td> <td>HBGF-5</td> <td>Hair follicle<br /> development and <br /> growth cycle regulation</td> <td>• FGF5 overexpression - glioblastoma</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-6&numResults=25">FGF-6</a></td> <td>HBGF-6; HST-2</td> <td>Muscle development<br /> and regeneration</td> <td>• FGF6 overexpression - prostate cancer</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td class="blue_high" rowspan="2">Subfamily</td> <td class="blue_high" rowspan="2">Human Ligands</td> <td class="blue_high" rowspan="2" width="15%">Alternate Name</td> <td class="blue_high" rowspan="2">Physiological Function (Based on the knockout mouse phenotype)</td> <td class="blue_high" rowspan="2">Pathologies Associated with FGF Mutations</td> <td class="blue_high" colspan="7">Reported Receptor Binding Specificity</td> </tr> <tr style="background-color: #595A5A";> <td style="color: #FFFFFF">R1b</td> <td style="color: #FFFFFF">R1c</td> <td style="color: #FFFFFF">R2b</td> <td style="color: #FFFFFF">R2c</td> <td style="color: #FFFFFF">R3b</td> <td style="color: #FFFFFF">R3c</td> <td style="color: #FFFFFF">R4</td> </tr> <tr> <td rowspan="4">FGF-7</td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-3">FGF-3</a></td> <td>HBGF-3; INT2</td> <td>Inner ear development</td> <td>• FGF3 haploinsufficiency - Otodental syndrome<br />• FGF3 missense/frameshift mutation - Michel aplasia, LAMM syndrome<br />• FGF3 amplification - breast cancer</td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-7">FGF-7</a></td> <td>KGF; HBGF-7</td> <td>Branching morphogenesis</td> <td>• FGF7 polymorphism - COPD<br />• FGF7 overexpression - lung adenocarcinoma</td> <td> </td> <td></td> <td>X</td> <td></td> <td> </td> <td></td> <td> </td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-10&numResults=25">FGF-10</a></td> <td>KGF-2</td> <td>Branching morphogenesis; Inner ear development</td> <td>• FGF10 nonsense mutation - Aplasia of the lacrimal and salivary glands (ALSG), Lacrimo-auriculo-dento-digital (LADD) syndrome<br /> • FGF10 polymorphism - severe myopia<br />• FGF10 overexpression - breast cancer, prostate cancer</td> <td>X</td> <td></td> <td>X</td> <td></td> <td> </td> <td></td> <td> </td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-22">FGF-22</a></td> <td> </td> <td>Presynapitc neural organizer</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td class="blue_high" rowspan="2">Subfamily</td> <td class="blue_high" rowspan="2">Human Ligands</td> <td class="blue_high" rowspan="2" width="15%">Alternate Name</td> <td class="blue_high" rowspan="2">Physiological Function (Based on the knockout mouse phenotype)</td> <td class="blue_high" rowspan="2">Pathologies Associated with FGF Mutations</td> <td class="blue_high" colspan="7">Reported Receptor Binding Specificity</td> </tr> <tr style="background-color: #595A5A";> <td style="color: #FFFFFF">R1b</td> <td style="color: #FFFFFF">R1c</td> <td style="color: #FFFFFF">R2b</td> <td style="color: #FFFFFF">R2c</td> <td style="color: #FFFFFF">R3b</td> <td style="color: #FFFFFF">R3c</td> <td style="color: #FFFFFF">R4</td> </tr> <tr> <td rowspan="6"><a href="https://www.rndsystems.com/search?keywords=FGF-8">FGF-8</a></td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-8a">FGF-8a</a></td> <td>AIGF; HBGF-8</td> <td rowspan="4">Brain, eye, ear, heart, kidney, and limb bud development</td> <td rowspan="4">• FGF8 nonsense mutation - Familial hypogonadotropic hypogonadism <br /> • FGF8 missense mutation - cleft lip and palate, holoprosencephaly, craniofacial defects, hypothalamo-pituitary dysfunction</td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-8b">FGF-8b</a></td> <td>AIGF; HBGF-8</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-8e">FGF-8e</a></td> <td>AIGF; HBGF-8</td> <td> </td> <td></td> <td> </td> <td></td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-8f">FGF-8f</a></td> <td>AIGF; HBGF-8</td> <td> </td> <td></td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-17">FGF-17</a></td> <td>FGF-13</td> <td>Brain development</td> <td>• FGF17 missense mutation - Familial hypogonadotropic hypogonadism<br />• FGF17 overexpression - hepatocellular carcinoma, prostate cancer</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-18">FGF-18</a></td> <td>ZFGF5</td> <td>Bone development; Lung alveolar development</td> <td>• FGF18 polymorphism - nonsyndromic cleft lip and palate<br />• FGF18 overexpression - hepatocellular carcinoma</td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td class="blue_high" rowspan="2">Subfamily</td> <td class="blue_high" rowspan="2">Human Ligands</td> <td class="blue_high" rowspan="2" width="15%">Alternate Name</td> <td class="blue_high" rowspan="2">Physiological Function (Based on the knockout mouse phenotype)</td> <td class="blue_high" rowspan="2">Pathologies Associated with FGF Mutations</td> <td class="blue_high" colspan="7">Reported Receptor Binding Specificity</td> </tr> <tr style="background-color: #595A5A";> <td style="color: #FFFFFF">R1b</td> <td style="color: #FFFFFF">R1c</td> <td style="color: #FFFFFF">R2b</td> <td style="color: #FFFFFF">R2c</td> <td style="color: #FFFFFF">R3b</td> <td style="color: #FFFFFF">R3c</td> <td style="color: #FFFFFF">R4</td> </tr> <tr> <td rowspan="3">FGF-9</td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-9">FGF-9</a></td> <td>GAF; HBGF-9</td> <td>Organogenesis; Gonad development; Inner ear development</td> <td>• FGF9 missense mutation - Multiple synostosis syndrome (SYNS) <br />• FGF9 promoter mutation - Sertoli cell-only syndrome (SCOS) <br />• FGF9 frameshift/missense/nonsense mutations - colorectal cancer, endometrial cancer<br />• FGF9 overexpression - non-small cell lung cancer</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-16">FGF-16</a></td> <td>MF4</td> <td>Heart development</td> <td>• FGF16 nonsense mutation - metacarpal 4-5 fusion<br />• FGF16 overexpression - ovarian cancer</td> <td> </td> <td></td> <td> </td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> </tr> <tr> <td><a href="https://www.rndsystems.com/search?keywords=FGF-20">FGF-20</a></td> <td>RHDA2</td> <td>Neurotrophic factor</td> <td>• FGF20 polymorphism - risk of Parkinson's disease<br />• FGF20 frameshift mutation - bilateral renal agenesis</td> <td> </td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> <td>X</td> </tr> <tr> <td class="blue_high" rowspan="2">Subfamily</td> <td class="blue_high" rowspan="2">Human Ligands</td> <td class="blue_high" rowspan="2" width="15%">Alternate Name</td> <td class="blue_high" rowspan="2">Physiological Function (Based on the knockout mouse phenotype)</td> <td class="blue_high" rowspan="2">Pathologies Associated with FGF Mutations</td> <td class="blue_high" colspan="7">Reported Receptor Binding Specificity</td> </tr> <tr style="background-color: #595A5A";> <td style="color: #FFFFFF">R1b</td> <td style="color: #FFFFFF">R1c</td> <td style="color: #FFFFFF">R2b</td> <td style="color: #FFFFFF">R2c</td> <td style="color: #FFFFFF">R3b</td> <td style="color: #FFFFFF">R3c</td> <td style="color: #FFFFFF">R4</td> </tr> <tr> <td>FGF-11</td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-11">FGF-11</a></td> <td>FHF-3</td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-12">FGF-12</a></td> <td>FHF-1</td> <td> </td> <td>• FGF12 missense mutation - Brugada syndrome</td> <td> </td> <td></td> <td> </td> <td></td> <td> </td> <td></td> <td> </td> </tr> <tr> <td> </td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-13">FGF-13</a></td> <td>FHF-2</td> <td>Neuronal migration; Learning and memory</td> <td>• FGF13 nonsense mutation - Borjeson-Forssman-Lehmann syndrome (BFLS)<br />• Low FGF13 expression - X-linked congenital generalized hypertrichosis</td> <td> </td> <td></td> <td> </td> <td></td> <td> </td> <td></td> <td> </td> </tr> <tr> <td> </td> <td>FGF-14</td> <td>FHF-4</td> <td>Neuronal firing; Movement and coordination; Learning and memory</td> <td>• FGF14 missense/deletion/translocation mutations - Spinocerebellar ataxia 27 (SCA27)</td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td class="blue_high" rowspan="2">Subfamily</td> <td class="blue_high" rowspan="2">Human Ligands</td> <td class="blue_high" rowspan="2" width="15%">Alternate Name</td> <td class="blue_high" rowspan="2">Physiological Function (Based on the knockout mouse phenotype)</td> <td class="blue_high" rowspan="2">Pathologies Associated with FGF Mutations</td> <td class="blue_high" colspan="7">Reported Receptor Binding Specificity</td> </tr> <tr style="background-color: #595A5A";> <td style="color: #FFFFFF">R1b</td> <td style="color: #FFFFFF">R1c</td> <td style="color: #FFFFFF">R2b</td> <td style="color: #FFFFFF">R2c</td> <td style="color: #FFFFFF">R3b</td> <td style="color: #FFFFFF">R3c</td> <td style="color: #FFFFFF">R4</td> </tr> <tr> <td>FGF-19</td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-19&numResults=25">FGF-19</a> </td> <td>FGF-15 (mouse)</td> <td>Bile acid metabolism; lipolysis; gall bladder filling</td> <td>• FGF19 overexpression - prostate cancer, hepatocellular carcinoma</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td> </td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-21&numResults=50">FGF-21</a></td> <td></td> <td>Energy/lipid metabolism</td> <td>• FGF21 polymorphism - increased risk of obesity and type 2 diabetes</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> <tr> <td> </td> <td><a href="https://www.rndsystems.com/search?keywords=FGF-23">FGF-23</a></td> <td>ADHR; HPDR2; HYPF</td> <td>Phosphate and vitamin D homeostasis; Middle ear development</td> <td>• FGF23 missense mutation - Autosomal dominant hypophosphatemic rickets (ADHR), Familial tumoral calcinosis (FTC)<br />• FGF23 polymorphism - cardiac abnormalities in Kawasaki syndrome, increased risk of prostate cancer</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td> </td> <td>X</td> <td>X</td> </tr> </tbody> </table></p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" id="collapsePathwayRequest"> <div id="pathwayRequestWebformWrapper"> <form class="webform-client-form webform-client-form-27981" action="/pathways/fgf-signaling-pathways" method="post" id="webform-client-form-27981" accept-charset="UTF-8"><div><div class="form-item webform-component webform-component-textfield webform-component--first-name form-group form-item 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