Home - Pathios Therapeutics

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href="https://pathiostherapeutics.com/the-board/">The Board</a></li><li><a href="https://pathiostherapeutics.com/investors/">Investors</a></li><li><a href="https://pathiostherapeutics.com/latest-news-updates/">News</a></li><li><a href="https://pathiostherapeutics.com/contact-us/">Contact Us</a></li>   </ul>  </ul> </div> </nav> </div> </div> </header> <div class="home-feature-wrapper"> <div class="page-header-bg" style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/07/pathios-hero-home.png');" ></div> <div class="home-feature-bg"> <div class="container"> <div class="col-xs-9 col-sm-6 col-md-5 col-lg-5 column pos-rel "> <div class="home-content-wrapper center-me v-only"> <div class="spacer-60 visible-xs visible-sm"></div> <h1 class="">Using human genetics to transform cancer outcomes</h1> <h2 class="f-main p">Pathios is a clinical-stage oncology and immunology company that targets the acid-sensing GPCR, GPR65, as a unique and genetically-validated immune cell receptor with the potential to revolutionise oncology treatment across multiple solid tumor types</h2> <a href="https://pathiostherapeutics.com/science/" class="btn btn-yellow">Find out more </a> </div> </div> <div class="clearfix"></div> </div> </div> </div>  <section id="home-content-anchor"> <div class="content-block full-width " > <div style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/08/blob-blue-1.png');" class=" background-img" ></div> <div style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/08/blob-blue-2.png');" class=" background-img img-right" ></div> <div class="container" > <div class="row "> <div class="col-sm-10 col-sm-offset-1 col-lg-10 col-lg-offset-1 text-center text-wrapper-white box-shadow-light "> <h3 class=" k no-margin">We are the only company that is addressing the underlying causal biology that links the ubiquitous acidic tumor microenvironment (TME) with a detrimental alteration of immune cell function</h3> <div class="spacer-20"></div> <p>In depth scientific analysis has shown that GPR65’s ability to sense low pH leads multiple immune cells to adopt a pro-tumorigenic, immunosuppressed phenotype. Unlike other approaches, which seek to artificially activate immune cells within the tumor, inhibition of GPR65 addresses the root cause of dysfunctional immune cells within the TME</p> <div class="spacer-10"></div> </div> </div> </div> </div> <div class="clearfix"></div> <div class="content-block columns-2 no-padding bg-gray-darker " > <div class="" > <div class="match-heights "> <div class="col-xs-12 col-md-6 item columns-2-text "> <p class="f-xs uc ls-2">Science</p> <h2 class="title f">Pioneering a uniquely human genetics-led approach to addressing the immunologically hostile tumor microenvironment (TME) and the underlying causal biology of immune cell dysfunction in cancer</h2> <p>The acidic TME inherent to all solid cancers causes a profound alteration of tumor-infiltrating immune cells. This occurs through the activation of the acid-sensing GPCR, GPR65, leading to a disarming of the anti-cancer immune response and rendering current immunotherapies ineffective. The detrimental impact of low pH acting via GPR65 occurs across a range of different immune cell subtypes including cytotoxic T cells, natural killer (NK) cells, dendritic cells (DCs) and macrophages. In the case of macrophages this signalling can explain all of the cardinal features of tumor associated macrophages (TAMs) thus constituting a fundamental and ubiquitous piece of pro-tumorigenic causal biology.</p> <p>Pathios has unique insights into the science of inhibiting GPR65 and will be the first company in the world to advance this novel mechanism into cancer patients with its lead asset, PTT-4256. PTT-4256 is an orally-bioavailable, highly potent and selective GPR65 inhibitor with the potential to be a first-in-class treatment in the cancer immunotherapy space.</p> <div class="spacer-20"></div> </div> <div class="col-xs-12 col-md-6 no-padding columns-2-img item hidden-xs hidden-ms hidden-sm" style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/07/blob-green-close-835x1024.png');"> <img src="https://pathiostherapeutics.com/wp-content/uploads/2019/07/blob-green-close.png" alt="" class="img-responsive visible-xs visible-sm" > </div> </div> </div> <div class="clearfix"></div> </div> <div class="content-block news-widget " "> <div style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/08/blob-blue-6.png');" class=" background-img" ></div> <div style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/08/blob-blue-6.png');" class=" background-img img-right" ></div> <div class="col-xs-12 text-center"> <h2 class="no-margin">News</h2> </div> <div class="spacer-20"></div> <div class="news-widget-wrapper"> <div class="container"> <div class="row "> <div class="col-xs-12 col-lg-10 col-lg-offset-1 match-heights"> <div class="col-sm-5 item news-item text-center"> <div class="row"> <div class="col-xs-12"> <div class="spacer-20 hidden-xs hidden-ms hidden-sm"></div> <p class="f-xs uc">March 24, 2025</p> <a href="https://pathiostherapeutics.com/pathios-therapeutics-appoints-sumeet-ambarkhane-m-d-as-chief-medical-officer/" class=""><h4>Pathios Therapeutics Appoints Sumeet Ambarkhane, M.D., as Chief Medical Officer</h4></a> <div class="news-image"> <a href="https://pathiostherapeutics.com/pathios-therapeutics-appoints-sumeet-ambarkhane-m-d-as-chief-medical-officer/"><img width="2000" height="600" src="https://pathiostherapeutics.com/wp-content/uploads/2025/03/Gradient-3.jpg" class="attachment-full size-full wp-post-image" alt="" decoding="async" fetchpriority="high" srcset="https://pathiostherapeutics.com/wp-content/uploads/2025/03/Gradient-3.jpg 2000w, https://pathiostherapeutics.com/wp-content/uploads/2025/03/Gradient-3-300x90.jpg 300w, https://pathiostherapeutics.com/wp-content/uploads/2025/03/Gradient-3-1024x307.jpg 1024w, https://pathiostherapeutics.com/wp-content/uploads/2025/03/Gradient-3-768x230.jpg 768w, https://pathiostherapeutics.com/wp-content/uploads/2025/03/Gradient-3-1536x461.jpg 1536w" sizes="(max-width: 2000px) 100vw, 2000px" /></a> </div> <div class="spacer-20 hidden-xs"></div> <a href="https://pathiostherapeutics.com/pathios-therapeutics-appoints-sumeet-ambarkhane-m-d-as-chief-medical-officer/" class="btn btn-yellow btn-sm">Read Article</a> <div class="spacer-10 "></div> </div> </div> </div> <div class="col-sm-2 item pathios-seperator"> </div> <div class="col-sm-5 item news-item text-center"> <div class="row"> <div class="col-xs-12"> <div class="spacer-20 hidden-xs hidden-ms hidden-sm"></div> <p class="f-xs uc">November 20, 2024</p> <a href="https://pathiostherapeutics.com/pathios-therapeutics-announces-dosing-of-first-patient-in-phase-1-2-clinical-study-of-gpr65-inhibitor-ptt-4256-in-patients-with-advanced-solid-cancers/" class=""><h4>Pathios Therapeutics Announces Dosing of First Patient in Phase 1/2 Clinical Study of GPR65 Inhibitor PTT-4256 in Patients with Advanced Solid Cancers</h4></a> <div class="news-image"> <a href="https://pathiostherapeutics.com/pathios-therapeutics-announces-dosing-of-first-patient-in-phase-1-2-clinical-study-of-gpr65-inhibitor-ptt-4256-in-patients-with-advanced-solid-cancers/"><img width="2000" height="600" src="https://pathiostherapeutics.com/wp-content/uploads/2024/11/Light-9.png" class="attachment-full size-full wp-post-image" alt="" decoding="async" srcset="https://pathiostherapeutics.com/wp-content/uploads/2024/11/Light-9.png 2000w, https://pathiostherapeutics.com/wp-content/uploads/2024/11/Light-9-300x90.png 300w, https://pathiostherapeutics.com/wp-content/uploads/2024/11/Light-9-1024x307.png 1024w, https://pathiostherapeutics.com/wp-content/uploads/2024/11/Light-9-768x230.png 768w, https://pathiostherapeutics.com/wp-content/uploads/2024/11/Light-9-1536x461.png 1536w" sizes="(max-width: 2000px) 100vw, 2000px" /></a> </div> <div class="spacer-20 hidden-xs"></div> <a href="https://pathiostherapeutics.com/pathios-therapeutics-announces-dosing-of-first-patient-in-phase-1-2-clinical-study-of-gpr65-inhibitor-ptt-4256-in-patients-with-advanced-solid-cancers/" class="btn btn-yellow btn-sm">Read Article</a> <div class="spacer-10 "></div> </div> </div> </div> </div> </div> </div> </div> <div class="clearfix"></div> </div> <div class="content-block full-width " > <div style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/08/blob-blue-4.png');" class=" background-img" ></div> <div class="container" > <div class="row "> <div class="col-sm-10 col-sm-offset-1 col-lg-10 col-lg-offset-1 text-center text-wrapper-white box-shadow-light bg-gray-darker"> <h3 class=" f no-margin">Pathios' AACR Poster 2023</h3> <div class="spacer-20"></div> <p>PTT-4256 is a first-in-class GPR65 inhibitor that reverses the immuno-suppressive effects of acidic pH in macrophages, activates anti-tumorigenic pathways in the tumour microenvironment and displays single agent anti-tumour efficacy in mice.</p> <div class="spacer-10"></div> <div class="text-center"> <div class="spacer-10"></div> <a href="https://pathiostherapeutics.com/scientific-poster-presentations/" class="btn btn-accent">Download Now</a> </div> </div> </div> </div> </div> <div class="clearfix"></div> <div class="content-block full-width " > <div style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/08/blob-blue-4.png');" class=" background-img" ></div> <div style="background-image: url('https://pathiostherapeutics.com/wp-content/uploads/2019/08/blob-blue-3.png');" class=" 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It records data on the visitor's consent regarding various privacy policies and settings, ensuring that their preferences are honored in future sessions.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">YSC</td><td class="cookielawinfo-column-3">6 months</td><td class="cookielawinfo-column-4">This cookie is set by YouTube to track views of embedded videos.</td></tr></tbody></table> </div> </div> </div> </div> <div class="cli-tab-section"> <div class="cli-tab-header"> <a role="button" tabindex="0" class="cli-nav-link cli-settings-mobile" data-target="performance" data-toggle="cli-toggle-tab"> Performance </a> <div class="cli-switch"> <input type="checkbox" id="wt-cli-checkbox-performance" class="cli-user-preference-checkbox" data-id="checkbox-performance" /> <label for="wt-cli-checkbox-performance" class="cli-slider" data-cli-enable="Enabled" data-cli-disable="Disabled"><span class="wt-cli-sr-only">Performance</span></label> </div> </div> <div class="cli-tab-content"> <div class="cli-tab-pane cli-fade" data-id="performance"> <div class="wt-cli-cookie-description"> Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors. </div> </div> </div> </div> <div class="cli-tab-section"> <div class="cli-tab-header"> <a role="button" tabindex="0" class="cli-nav-link cli-settings-mobile" data-target="analytics" data-toggle="cli-toggle-tab"> Analytics </a> <div class="cli-switch"> <input type="checkbox" id="wt-cli-checkbox-analytics" class="cli-user-preference-checkbox" data-id="checkbox-analytics" /> <label for="wt-cli-checkbox-analytics" class="cli-slider" data-cli-enable="Enabled" data-cli-disable="Disabled"><span class="wt-cli-sr-only">Analytics</span></label> </div> </div> <div class="cli-tab-content"> <div class="cli-tab-pane cli-fade" data-id="analytics"> <div class="wt-cli-cookie-description"> Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. <table class="cookielawinfo-row-cat-table cookielawinfo-winter"><thead><tr><th class="cookielawinfo-column-1">Cookie</th><th class="cookielawinfo-column-3">Duration</th><th class="cookielawinfo-column-4">Description</th></tr></thead><tbody><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">_ga</td><td class="cookielawinfo-column-3">1 year 1 month 4 days</td><td class="cookielawinfo-column-4">Google Analytics sets this cookie to calculate visitor, session and campaign data and track site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognise unique visitors.</td></tr><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">_ga_*</td><td class="cookielawinfo-column-3">1 year 1 month 4 days</td><td class="cookielawinfo-column-4">Google Analytics sets this cookie to store and count page views.</td></tr></tbody></table> </div> </div> </div> </div> <div class="cli-tab-section"> <div class="cli-tab-header"> <a role="button" tabindex="0" class="cli-nav-link cli-settings-mobile" data-target="advertisement" data-toggle="cli-toggle-tab"> Advertisement </a> <div class="cli-switch"> <input type="checkbox" id="wt-cli-checkbox-advertisement" class="cli-user-preference-checkbox" data-id="checkbox-advertisement" /> <label for="wt-cli-checkbox-advertisement" class="cli-slider" data-cli-enable="Enabled" data-cli-disable="Disabled"><span class="wt-cli-sr-only">Advertisement</span></label> </div> </div> <div class="cli-tab-content"> <div class="cli-tab-pane cli-fade" data-id="advertisement"> <div class="wt-cli-cookie-description"> Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads. </div> </div> </div> </div> <div class="cli-tab-section"> <div class="cli-tab-header"> <a role="button" tabindex="0" class="cli-nav-link cli-settings-mobile" data-target="others" data-toggle="cli-toggle-tab"> Others </a> <div class="cli-switch"> <input type="checkbox" id="wt-cli-checkbox-others" class="cli-user-preference-checkbox" data-id="checkbox-others" /> <label for="wt-cli-checkbox-others" class="cli-slider" data-cli-enable="Enabled" data-cli-disable="Disabled"><span class="wt-cli-sr-only">Others</span></label> </div> </div> <div class="cli-tab-content"> <div class="cli-tab-pane cli-fade" data-id="others"> <div class="wt-cli-cookie-description"> Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. <table class="cookielawinfo-row-cat-table cookielawinfo-winter"><thead><tr><th class="cookielawinfo-column-1">Cookie</th><th class="cookielawinfo-column-3">Duration</th><th class="cookielawinfo-column-4">Description</th></tr></thead><tbody><tr class="cookielawinfo-row"><td class="cookielawinfo-column-1">cerber_groove cerber_groove_x_#</td><td class="cookielawinfo-column-3">14 days</td><td class="cookielawinfo-column-4">Protect the website from hackers, cyber criminals, spammers</td></tr></tbody></table> </div> </div> </div> </div> </div> </div> </div> </div> <div class="cli-modal-footer"> <div class="wt-cli-element cli-container-fluid cli-tab-container"> <div class="cli-row"> <div class="cli-col-12 cli-align-items-stretch cli-px-0"> <div class="cli-tab-footer wt-cli-privacy-overview-actions"> <a id="wt-cli-privacy-save-btn" role="button" tabindex="0" data-cli-action="accept" class="wt-cli-privacy-btn cli_setting_save_button wt-cli-privacy-accept-btn cli-btn">SAVE & ACCEPT</a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="cli-modal-backdrop cli-fade cli-settings-overlay"></div> <div class="cli-modal-backdrop cli-fade cli-popupbar-overlay"></div> <script type="text/javascript"> document.addEventListener('wpcf7mailsent', function(event) { if ('21' == event.detail.contactFormId) { //if the form if equals #101 $('.contact-form-wrapper').html( "<div class='text-left'><h2>Thank you for your enquiry</h2><h5>Our team will respond to you within 2 business days.</h5></div>" ); } else if ('648' == event.detail.contactFormId) { //if the form if equals #365 $('#subscription-form-wrapper .wpcf7').html("<h4>Thanks. 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