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Mansoor</title> <meta name="description" content="Search results for: Mohtashim Mansoor"> <meta name="keywords" content="Mohtashim Mansoor"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Mohtashim Mansoor"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 38</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Mohtashim Mansoor</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Single Tuned Shunt Passive Filter Based Current Harmonic Elimination of Three Phase AC-DC Converters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mansoor%20Soomro">Mansoor Soomro</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The evolution of power electronic equipment has been pivotal in making industrial processes productive, efficient and safe. Despite its attractive features, it has been due to nonlinear loads which make it vulnerable to power quality conditions. Harmonics is one of the power quality problem in which the harmonic frequency is integral multiple of supply frequency. Therefore, the supply voltage and supply frequency do not last within their tolerable limits. As a result, distorted current and voltage waveform may appear. Attributes of low power quality confirm that an electrical device or equipment is likely to malfunction, fail promptly or unable to operate under all applied conditions. The electrical power system is designed for delivering power reliably, namely maximizing power availability to customers. However, power quality events are largely untracked, and as a result, can take out a process as many as 20 to 30 times a year, costing utilities, customers and suppliers of load equipment, a loss of millions of dollars. The ill effects of current harmonics reduce system efficiency, cause overheating of connected equipment, result increase in electrical power and air conditioning costs. With the passage of time and the rapid growth of power electronic converters has highlighted the damages of current harmonics in the electrical power system. Therefore, it has become essential to address the bad influence of current harmonics while planning any suitable changes in the electrical installations. In this paper, an effort has been made to mitigate the effects of dominant 3rd order current harmonics. Passive filtering technique with six pulse multiplication converter has been employed to mitigate them. Since, the standards of power quality are to maintain the supply voltage and supply current within certain prescribed standard limits. For this purpose, the obtained results are validated as per specifications of IEEE 519-1992 and IEEE 519-2014 performance standards. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=current%20harmonics" title="current harmonics">current harmonics</a>, <a href="https://publications.waset.org/abstracts/search?q=power%20quality" title=" power quality"> power quality</a>, <a href="https://publications.waset.org/abstracts/search?q=passive%20filters" title=" passive filters"> passive filters</a>, <a href="https://publications.waset.org/abstracts/search?q=power%20electronic%20converters" title=" power electronic converters"> power electronic converters</a> </p> <a href="https://publications.waset.org/abstracts/65401/single-tuned-shunt-passive-filter-based-current-harmonic-elimination-of-three-phase-ac-dc-converters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65401.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">301</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Hospital Acquired Bloodstream Infections Among Patients With Hematological and Solid Malignancies: Epidemiology, Causative Pathogens and Mortality</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marah%20El-Beeli">Marah El-Beeli</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20Balkhair"> Abdullah Balkhair</a>, <a href="https://publications.waset.org/abstracts/search?q=Zakaryia%20Al%20Muharmi"> Zakaryia Al Muharmi</a>, <a href="https://publications.waset.org/abstracts/search?q=Samir%20Al%20Adawi"> Samir Al Adawi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mansoor%20Al-Jabri"> Mansoor Al-Jabri</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdullah%20Al%20Rawahi"> Abdullah Al Rawahi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hazaa%20Al%20Yahyae"> Hazaa Al Yahyae</a>, <a href="https://publications.waset.org/abstracts/search?q=Eman%20Al%20Balushi"> Eman Al Balushi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yahya%20M.%20Al-Farsi"> Yahya M. Al-Farsi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The health care service and the anticancer chemotherapeutics has changed the natural history of cancer into manageable chronic disease and improve the cancer patient’s lifestyle and increase the survival time. Despite that, still, infection is the major dilemma opposing the cancer patient either because of the clinical presentation of the cancer type and impaired immune system or as a consequence of anticancer therapy. This study has been conducted to1) track changes in the epidemiology of hospital-acquired bloodstream infections among patients with malignancies in the last five years. 2) To explore the causative pathogens and 3) the outcome of HA-BSIs in patients with a different types of malignancies. An ampi-directional study (retrospective and prospective follow up) of patients with malignancies admitted at Sultan Qaboos University hospital (570-bed tertiary hospital) during the study period (from January 2015 to December 2019). The cumulative frequency and prevalence rates of HA-BSIs by patients and isolates were calculated. In addition, the cumulative frequency of participants with single versus mixed infections and types of causative micro-organisms of HA-BSIs were obtained. A total of 1246 event of HA-BSIs has occurred during the study period. Nearly the third (30.25%) of the HA-BSI events was identified among 288 patients with malignancies. About 20% of cases were mixed infections (more than one isolate). Staphylococcus spp were the predominant isolated pathogen (24.7%), followed by Klebsiella spp (15.8%), Escherichia spp (13%), and Pseudomonas spp (9.3%). About half (51%) of cases died in the same year, and (64%) of the deaths occur within two weeks after the infection. According to the observations, no changes in the trends of epidemiology, causative pathogens, morbidity, and mortality rates in the last five years. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epidemiology" title="epidemiology">epidemiology</a>, <a href="https://publications.waset.org/abstracts/search?q=haematological%20malignancies" title=" haematological malignancies"> haematological malignancies</a>, <a href="https://publications.waset.org/abstracts/search?q=hospital%20acquired%20bloodstream%20infections" title=" hospital acquired bloodstream infections"> hospital acquired bloodstream infections</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20malignancies" title=" solid malignancies"> solid malignancies</a> </p> <a href="https://publications.waset.org/abstracts/125092/hospital-acquired-bloodstream-infections-among-patients-with-hematological-and-solid-malignancies-epidemiology-causative-pathogens-and-mortality" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/125092.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">150</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Alterations in Esterases and Phosphatases of Three Economically Important Stored Grain Insect Pests Exposed to Botanical Extracts, Nicotiana tabacum and Eucalyptus globulus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kazam%20Ali">Kazam Ali</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Sagheer"> Muhammad Sagheer</a>, <a href="https://publications.waset.org/abstracts/search?q=Mansoor-Ul-%20Hasan"> Mansoor-Ul- Hasan</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Rashid"> Abdul Rashid</a>, <a href="https://publications.waset.org/abstracts/search?q=Chaudhary%20Muhammad%20Shahid%20Hanif"> Chaudhary Muhammad Shahid Hanif</a>, <a href="https://publications.waset.org/abstracts/search?q=Fawad%20Zafar%20Ahmad%20Khan"> Fawad Zafar Ahmad Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Hafiz%20Muhammad%20Aatif"> Hafiz Muhammad Aatif</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural extracts of two medicinal plants Nicotiana tabacum and Eucalyptus globulus were tested for their toxic and enzyme inhibition effects against three insects species of stored grains Tribolium castaneum, Trogoderma granarium and Sitophilus granarius. Responses of insects varied with exposure periods and dilution levels of acetone extracts of plants. Both plant extracts were lethal to insects but the crude leaf extract of N. tabacum evidenced strong toxic action against three tested insect species. Maximum mortality 36.30% in S. granarius, 25.96% in T. castaneum, and 21.88% in T. granarium were found at 20% dilution level, after 10 days exposure to botanical extract of N. tabacum. The impact of N. tabacum and E. globulus on the activity of esterases; acetylcholinesterase (AChE), α-carboxylesterase (α-CE), β-carboxylesterase (β-CE) and phosphatses; acid phosphatase (AcP), alkaline phosphatase (AlP) of three stored grain insect species were also studied in the survivors of toxicity assay. Whole body homogenates of insects were used for enzyme determination and consumption of high dose rate N. tabacum extract containing diet resulted in maximum 55.33% inhibition of AChE and 26.17% AlP inhibition in T. castaneum, while 44.17% of α-CE and 31.67% inhibition of β-CE activity were noted in S. granarius. Maximum inhibition 23.44% of AcP activity was found in T. granarium exposed to diet treated with the extract of E. globulus. The findings indicate that acetone extracts of N. tabacum and E. globulus are naturally occurring pesticide and facts of the enzyme inhibition relations specify that their effect changes with the insect species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=natural%20extract" title="natural extract">natural extract</a>, <a href="https://publications.waset.org/abstracts/search?q=medicinal%20plant" title=" medicinal plant"> medicinal plant</a>, <a href="https://publications.waset.org/abstracts/search?q=toxic%20effects" title=" toxic effects"> toxic effects</a>, <a href="https://publications.waset.org/abstracts/search?q=enzyme%20inhibition" title=" enzyme inhibition"> enzyme inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=acetone%20extract" title=" acetone extract"> acetone extract</a> </p> <a href="https://publications.waset.org/abstracts/78395/alterations-in-esterases-and-phosphatases-of-three-economically-important-stored-grain-insect-pests-exposed-to-botanical-extracts-nicotiana-tabacum-and-eucalyptus-globulus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78395.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">258</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Human TP53 Three Dimentional (3D) Core Domain Hot Spot Mutations at Codon, 36, 72 and 240 are Associated with Oral Squamous Cell Carcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saima%20Saleem">Saima Saleem</a>, <a href="https://publications.waset.org/abstracts/search?q=Zubair%20Abbasi"> Zubair Abbasi</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdul%20Hameed"> Abdul Hameed</a>, <a href="https://publications.waset.org/abstracts/search?q=Mansoor%20Ahmed%20Khan"> Mansoor Ahmed Khan</a>, <a href="https://publications.waset.org/abstracts/search?q=Navid%20Rashid%20Qureshi"> Navid Rashid Qureshi</a>, <a href="https://publications.waset.org/abstracts/search?q=Abid%20Azhar"> Abid Azhar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oral Squamous Cell Carcinoma (OSCC) is the leading cause of death in the developing countries like Pakistan. This problem aggravates because of the excessive use of available chewing products. In spite of widespread information on their use and purported legislations against their use the Pakistani markets are classical examples of selling chewable carcinogenic mutagens. Reported studies indicated that these products are rich in reactive oxygen species (ROS) and polyphenols. TP53 gene is involved in the suppression of tumor. It has been reported that somatic mutations caused by TP53 gene are the foundation of the cancer. This study aims to find the loss of TP53 functions due to mutation/polymorphism caused by genomic alteration and interaction with tobacco and its related ingredients. Total 260 tissues and blood specimens were collected from OSCC patients and compared with age and sex matched controls. Mutations in exons 2-11 of TP53 were examined by PCR-SSCP. Samples showing mobility shift were directly sequenced. Two mutations were found in exon 4 at nucleotide position 108 and 215 and one in exon 7 at nucleotide position 719 of the coding sequences in patient’s tumor samples. These results show that substitution of proline with arginine at codon 72 and serine with threonine at codon 240 of p53 protein. These polymorphic changes, found in tumor samples of OSCC, could be involved in loss of heterozygocity and apoptotic activity in the binding domain of TP53. The model of the mutated TP53 gene elaborated a nonfunctional unfolded p53 protein, suggesting an important role of these mutations in p53 protein inactivation and malfunction. This nonfunctional 3D model also indicates that exogenous tobacco related carcinogens may act as DNA-damaging agents affecting the structure of DNA. The interpretations could be helpful in establishing the pathways responsible for tumor formation in OSCC patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=TP53%20mutation%2Fpolymorphism" title="TP53 mutation/polymorphism">TP53 mutation/polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=OSCC" title=" OSCC"> OSCC</a>, <a href="https://publications.waset.org/abstracts/search?q=PCR-SSCP" title=" PCR-SSCP"> PCR-SSCP</a>, <a href="https://publications.waset.org/abstracts/search?q=direct%20DNA%20sequencing" title=" direct DNA sequencing"> direct DNA sequencing</a>, <a href="https://publications.waset.org/abstracts/search?q=3D%20structure" title=" 3D structure"> 3D structure</a> </p> <a href="https://publications.waset.org/abstracts/13540/human-tp53-three-dimentional-3d-core-domain-hot-spot-mutations-at-codon-36-72-and-240-are-associated-with-oral-squamous-cell-carcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13540.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">366</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Managing Shallow Gas for Offshore Platforms via Fit-For-Purpose Solutions: Case Study for Offshore Malaysia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Noorizal%20Huang">Noorizal Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Christian%20Girsang"> Christian Girsang</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamad%20Razi%20Mansoor"> Mohamad Razi Mansoor</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Shallow gas seepage was first spotted at a central processing platform offshore Malaysia in 2010, acknowledged as Platform T in this paper. Frequent monitoring of the gas seepage was performed through remotely operated vehicle (ROV) baseline survey and a comprehensive geophysical survey was conducted to understand the characteristics of the gas seepage and to ensure that the integrity of the foundation at Platform T was not compromised. The origin of the gas back then was unknown. A soil investigation campaign was performed in 2016 to study the origin of the gas seepage. Two boreholes were drilled; a composite borehole to 150m below seabed for the purpose of soil sampling and in-situ testing and a pilot hole to 155m below the seabed, which was later converted to a fit-for-purpose relief well as an alternate migration path for the gas. During the soil investigation campaign, dissipation tests were performed at several layers which were potentially the source or migration path for the gas. Five (5) soil samples were segregated for headspace test, to identify the gas type which subsequently can be used to identify the origin of the gas. Dissipation tests performed at four depth intervals indicates pore water pressure less than 20 % of the effective vertical stress and appear to continue decreasing if the test had not been stopped. It was concluded that a low to a negligible amount of excess pore pressure exist in clayey silt layers. Results from headspace test show presence of methane corresponding to the clayey silt layers as reported in the boring logs. The gas most likely comes from biogenic sources, feeding on organic matter in situ over a large depth range. It is unlikely that there are large pockets of gas in the soil due to its homogeneous clayey nature and the lack of excess pore pressure in other permeable clayey silt layers encountered. Instead, it is more likely that when pore water at certain depth encounters a more permeable path, such as a borehole, it rises up through this path due to the temperature gradient in the soil. As the water rises the pressure decreases, which could cause gases dissolved in the water to come out of solution and form bubbles. As a result, the gas will have no impact on the integrity of the foundation at Platform T. The fit-for-purpose relief well design as well as adopting headspace testing can be used to address the shallow gas issue at Platform T in a cost effective and efficient manners. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dissipation%20test" title="dissipation test">dissipation test</a>, <a href="https://publications.waset.org/abstracts/search?q=headspace%20test" title=" headspace test"> headspace test</a>, <a href="https://publications.waset.org/abstracts/search?q=excess%20pore%20pressure" title=" excess pore pressure"> excess pore pressure</a>, <a href="https://publications.waset.org/abstracts/search?q=relief%20well" title=" relief well"> relief well</a>, <a href="https://publications.waset.org/abstracts/search?q=shallow%20gas" title=" shallow gas"> shallow gas</a> </p> <a href="https://publications.waset.org/abstracts/76798/managing-shallow-gas-for-offshore-platforms-via-fit-for-purpose-solutions-case-study-for-offshore-malaysia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76798.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Evaluation of the Photo Neutron Contamination inside and outside of Treatment Room for High Energy Elekta Synergy® Linear Accelerator</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sharib%20Ahmed">Sharib Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Mansoor%20Rafi"> Mansoor Rafi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamran%20Ali%20Awan"> Kamran Ali Awan</a>, <a href="https://publications.waset.org/abstracts/search?q=Faraz%20Khaskhali"> Faraz Khaskhali</a>, <a href="https://publications.waset.org/abstracts/search?q=Amir%20Maqbool"> Amir Maqbool</a>, <a href="https://publications.waset.org/abstracts/search?q=Altaf%20Hashmi"> Altaf Hashmi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Medical linear accelerators (LINAC’s) used in radiotherapy treatments produce undesired neutrons when they are operated at energies above 8 MeV, both in electron and photon configuration. Neutrons are produced by high-energy photons and electrons through electronuclear (e, n) a photonuclear giant dipole resonance (GDR) reactions. These reactions occurs when incoming photon or electron incident through the various materials of target, flattening filter, collimators, and other shielding components in LINAC’s structure. These neutrons may reach directly to the patient, or they may interact with the surrounding materials until they become thermalized. A work has been set up to study the effect of different parameter on the production of neutron around the room by photonuclear reactions induced by photons above ~8 MeV. One of the commercial available neutron detector (Ludlum Model 42-31H Neutron Detector) is used for the detection of thermal and fast neutrons (0.025 eV to approximately 12 MeV) inside and outside of the treatment room. Measurements were performed for different field sizes at 100 cm source to surface distance (SSD) of detector, at different distances from the isocenter and at the place of primary and secondary walls. Other measurements were performed at door and treatment console for the potential radiation safety concerns of the therapists who must walk in and out of the room for the treatments. Exposures have taken place from Elekta Synergy® linear accelerators for two different energies (10 MV and 18 MV) for a given 200 MU’s and dose rate of 600 MU per minute. Results indicates that neutron doses at 100 cm SSD depend on accelerator characteristics means jaw settings as jaws are made of high atomic number material so provides significant interaction of photons to produce neutrons, while doses at the place of larger distance from isocenter are strongly influenced by the treatment room geometry and backscattering from the walls cause a greater doses as compare to dose at 100 cm distance from isocenter. In the treatment room the ambient dose equivalent due to photons produced during decay of activation nuclei varies from 4.22 mSv.h−1 to 13.2 mSv.h−1 (at isocenter),6.21 mSv.h−1 to 29.2 mSv.h−1 (primary wall) and 8.73 mSv.h−1 to 37.2 mSv.h−1 (secondary wall) for 10 and 18 MV respectively. The ambient dose equivalent for neutrons at door is 5 μSv.h−1 to 2 μSv.h−1 while at treatment console room it is 2 μSv.h−1 to 0 μSv.h−1 for 10 and 18 MV respectively which shows that a 2 m thick and 5m longer concrete maze provides sufficient shielding for neutron at door as well as at treatment console for 10 and 18 MV photons. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=equivalent%20doses" title="equivalent doses">equivalent doses</a>, <a href="https://publications.waset.org/abstracts/search?q=neutron%20contamination" title=" neutron contamination"> neutron contamination</a>, <a href="https://publications.waset.org/abstracts/search?q=neutron%20detector" title=" neutron detector"> neutron detector</a>, <a href="https://publications.waset.org/abstracts/search?q=photon%20energy" title=" photon energy "> photon energy </a> </p> <a href="https://publications.waset.org/abstracts/23969/evaluation-of-the-photo-neutron-contamination-inside-and-outside-of-treatment-room-for-high-energy-elekta-synergy-linear-accelerator" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23969.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">449</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Synthesis, Computational Studies, Antioxidant and Anti-Inflammatory Bio-Evaluation of 2,5-Disubstituted- 1,3,4-Oxadiazole Derivatives</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sibghat%20Mansoor%20Rana">Sibghat Mansoor Rana</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Islam"> Muhammad Islam</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamid%20Saeed"> Hamid Saeed</a>, <a href="https://publications.waset.org/abstracts/search?q=Hummera%20Rafique"> Hummera Rafique</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Majid"> Muhammad Majid</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Tahir%20Aqeel"> Muhammad Tahir Aqeel</a>, <a href="https://publications.waset.org/abstracts/search?q=Fariha%20Imtiaz"> Fariha Imtiaz</a>, <a href="https://publications.waset.org/abstracts/search?q=Zaman%20Ashraf"> Zaman Ashraf</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The 1,3,4-oxadiazole derivatives Ox-6a-f have been synthesized by incorporating flur- biprofen moiety with the aim to explore the potential of target molecules to decrease the oxidative stress. The title compounds Ox-6a-f were prepared by simple reactions in which a flurbiprofen –COOH group was esterified with methanol in an acid-catalyzed medium, which was then reacted with hydrazine to afford the corresponding hydrazide. The acid hydrazide was then cyclized into 1,3,4-oxadiazole-2-thiol by reacting with CS2 in the presence of KOH. The title compounds Ox-6a-f were synthesized by the reaction of an –SH group with various alkyl/aryl chlorides, which involves an S-alkylation reaction. The structures of the synthesized Ox-6a-f derivatives were ascer- tained by spectroscopic data. The in silico molecular docking was performed against target proteins cyclooxygenase-2 COX-2 (PDBID 5KIR) and cyclooxygenase-1 COX-1 (PDBID 6Y3C) to determine the binding affinity of the synthesized compounds with these structures. It has been inferred that most of the synthesized compounds bind well with an active binding site of 5KIR compared to 6Y3C, and especially compound Ox-6f showed excellent binding affinity (7.70 kcal/mol) among all synthesized compounds Ox-6a-f. The molecular dynamic (MD) simulation has also been performed to check the stability of docking complexes of ligands with COX-2 by determining their root mean square deviation and root mean square fluctuation. Little fluctuation was observed in case of Ox-6f, which forms the most stable complex with COX-2. The comprehensive antioxidant potential of the synthesized compounds has been evaluated by determining their free radical scavenging activity, including DPPH, OH, nitric oxide (NO), and iron chelation assay. The derivative Ox-6f showed promising results with 80.23% radical scavenging potential at a dose of 100 μg/mL while ascorbic acid exhibited 87.72% inhibition at the same dose. The anti-inflammatory activity of the final products has also been performed, and inflammatory markers were assayed, such as a thiobarbituric acid-reducing substance, nitric oxide, interleukin-6 (IL-6), and COX-2. The derivatives Ox-6d and Ox-6f displayed higher anti-inflammatory activity, exhibiting 70.56% and 74.16% activity, respectively. The results were compared with standard ibuprofen, which showed 84.31% activity at the same dose, 200 μg/mL. The anti-inflammatory potential has been performed by following the carrageen-induced hind paw edema model, and results showed that derivative Ox-6f exhibited 79.83% reduction in edema volume compared to standard ibuprofen, which reduced 84.31% edema volume. As dry lab and wet lab results confirm each other, it has been deduced that derivative Ox-6f may serve as the lead structure to design potent compounds to address oxidative stress. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=synthetic%20chemistry" title="synthetic chemistry">synthetic chemistry</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmaceutical%20chemistry" title=" pharmaceutical chemistry"> pharmaceutical chemistry</a>, <a href="https://publications.waset.org/abstracts/search?q=oxadiazole%20derivatives" title=" oxadiazole derivatives"> oxadiazole derivatives</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-inflammatory" title=" anti-inflammatory"> anti-inflammatory</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-cancer%20compounds" title=" anti-cancer compounds"> anti-cancer compounds</a> </p> <a href="https://publications.waset.org/abstracts/193708/synthesis-computational-studies-antioxidant-and-anti-inflammatory-bio-evaluation-of-25-disubstituted-134-oxadiazole-derivatives" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/193708.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">15</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Arab and Arab-American Writers as Mediators between Arab and American Cultures in Response to Contemporary Media Representation of Arabs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mansoor%20Mohammed%20Abdu%20Al-Gabali">Mansoor Mohammed Abdu Al-Gabali</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper addresses the growing interest among non-Arab individuals in understanding the realities of Arab peoples and their cultures. The global media, particularly after the September 11 attacks, has contributed to negative and misrepresentative portrayals of Arabs. The paper aims to critically analyze various representations of identity, culture, and politics in the works of three contemporary Arab and Arab-American women writers. By exploring the perspectives and attitudes of these writers, the paper aims to challenge and rectify the misrepresentation created by the media and foster mutual understanding between Arab and American societies. Research Aim: The aim of this research is to examine the writings of Arab and Arab-American women in order to highlight the strengths and awareness of Arab cultures. It seeks to show how these writers create spaces for responding to the misrepresentation perpetuated by the media. The research contributes to bridging the gaps between Arab and American societies and fostering better mutual understanding. Methodology: This paper adopts a multidisciplinary approach, drawing on theoretical concepts from cultural studies. It also utilizes an inductive historical methodology to trace the works under study. The combination of these approaches allows for a comprehensive analysis of the representations of Arab peoples and cultures. Findings: The paper argues that the writings of Arab and Arab-American women demonstrate a multiplicity of perspectives and attitudes toward contemporary issues. It highlights the richness and diversity of their writing, as well as the connections they make between different periods of history and various sites of representation. The paper concludes that these writings transcend personal stories to incorporate broader national and global dialogues, emphasizing the commonalities shared by humanity and the socially contextualized issues that deserve respect. Theoretical Importance: This research holds theoretical importance in the field of cultural studies. It builds upon the works of scholars such as Jack Shaeen and Evelyn Alsultany, that have documented and critiqued the negative media representations of Arabs. By examining the writings of Arab and Arab-American women, this paper contributes to the theoretical understanding of cultural responses to media misrepresentation and the creation of spaces for mutual understanding. Data Collection and Analysis Procedures: The data collection for this research involved a thorough examination and analysis of the selected works by Elmaz Abinader, Diana Abu-Jaber, and Rajaa Al-Sanea. These works were scrutinized to identify the unique ways in which they tackled contemporary issues prevalent in Arab and Arab-American societies. Through close textual analysis and the application of cultural theories, the researchers were able to discern the underlying themes and messages conveyed in the writings. Question Addressed: The primary question addressed in this research is, "How do the writings of Arab and Arab-American women respond to the misrepresentation of Arab cultures in the media?" By exploring this question, the paper aims to shed light on the strengths and awareness of Arab cultures and to promote a more comprehensive understanding between Arabs and non-Arabs. Conclusion: This research concludes that the writings of Arab and Arab-American women serve as mediators between Arab and American cultures in response to the misrepresentation created by the media. These writings go beyond personal narratives, addressing broader social and cultural issues and seeking to highlight the commonalities shared by all human beings. The paper emphasizes the need for mutual respect and understanding in order to bridge the gaps between Arab and American societies and rectify the negative images that have been perpetuated in the media. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Arabs" title="Arabs">Arabs</a>, <a href="https://publications.waset.org/abstracts/search?q=films" title=" films"> films</a>, <a href="https://publications.waset.org/abstracts/search?q=media" title=" media"> media</a>, <a href="https://publications.waset.org/abstracts/search?q=negotiation" title=" negotiation"> negotiation</a> </p> <a href="https://publications.waset.org/abstracts/169594/arab-and-arab-american-writers-as-mediators-between-arab-and-american-cultures-in-response-to-contemporary-media-representation-of-arabs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/169594.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> 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