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class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Hazem Saleh</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://cairo.academia.edu/">Cairo University</a>, <a class="u-tcGrayDarker" href="https://cairo.academia.edu/Departments/Medical_Applications_of_Laser/Documents">Medical Applications of Laser</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button 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data-dom-id="Pill-react-component-dbc27075-2d83-4d94-a2c5-af030db8ea89"></div> <div id="Pill-react-component-dbc27075-2d83-4d94-a2c5-af030db8ea89"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="51052825" href="https://www.academia.edu/Documents/in/Laser"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Laser"]}" data-trace="false" data-dom-id="Pill-react-component-e6bbadcf-ba68-4400-b374-b30a881924bb"></div> <div id="Pill-react-component-e6bbadcf-ba68-4400-b374-b30a881924bb"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Hazem Saleh</h3></div><div class="js-work-strip profile--work_container" data-work-id="27022206"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022206/%EC%9D%B8%EA%B3%B5%EC%8A%B5%EC%A7%80%EC%9D%98_%EC%A1%B0%EC%84%B1%EB%B0%A9%EC%95%88_%EC%99%B8%EA%B5%AD%EC%9D%98_%EC%82%AC%EB%A1%80%EC%99%80_%ED%95%9C%EA%B5%AD%EC%97%90%EC%9D%98_%EC%A0%81%EC%9A%A9%EC%84%B1"><img alt="Research paper thumbnail of 인공습지의 조성방안 : 외국의 사례와 한국에의 적용성" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022206/%EC%9D%B8%EA%B3%B5%EC%8A%B5%EC%A7%80%EC%9D%98_%EC%A1%B0%EC%84%B1%EB%B0%A9%EC%95%88_%EC%99%B8%EA%B5%AD%EC%9D%98_%EC%82%AC%EB%A1%80%EC%99%80_%ED%95%9C%EA%B5%AD%EC%97%90%EC%9D%98_%EC%A0%81%EC%9A%A9%EC%84%B1">인공습지의 조성방안 : 외국의 사례와 한국에의 적용성</a></div><div class="wp-workCard_item"><span>2001년도 공동추계 학술발표회 논문집</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022206"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022206"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022206; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022206]").text(description); $(".js-view-count[data-work-id=27022206]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022206; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022206']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); 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Kim","title":"인공습지의 조성방안 : 외국의 사례와 한국에의 적용성"}],"downloadable_attachments":[],"slug":"인공습지의_조성방안_외국의_사례와_한국에의_적용성","translated_slug":"","page_count":null,"language":"ko","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[],"urls":[{"id":7328465,"url":"http://www.auric.or.kr/User/Rdoc/DocRdoc.aspx?returnVal=RD_R\u0026dn=196108"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022205"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022205/Transoral_Laser_Microsurgery_For_Early_Glottic_Cancer_Intraoperative_Narrow_Band_Imaging_Delineates_The_Superficial_Resection_Margins"><img alt="Research paper thumbnail of Transoral Laser Microsurgery For Early Glottic Cancer: Intraoperative Narrow Band Imaging Delineates The Superficial Resection Margins" class="work-thumbnail" src="https://attachments.academia-assets.com/47285981/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022205/Transoral_Laser_Microsurgery_For_Early_Glottic_Cancer_Intraoperative_Narrow_Band_Imaging_Delineates_The_Superficial_Resection_Margins">Transoral Laser Microsurgery For Early Glottic Cancer: Intraoperative Narrow Band Imaging Delineates The Superficial Resection Margins</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives To investigate the impact of intraoperative examination with narrow band imaging (NBI)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives To investigate the impact of intraoperative examination with narrow band imaging (NBI) coupled to high definition television (HDTV) on the incidence of positive superficial resection margins in patients affected by early glottic cancers and treated by transoral laser microsurgery (TLM). Materials and Methods Between January 2012 and October 2013 a total of 82 previously untreated patients (70 males, 12 female; average age: 67 years) affected by glottic cancer (Tis andT1a) were treated with excision biopsy in term of type I or II endoscopic cordectomies according to the ELS classification. NBI-HDTV was routinely used intraoperatively to guide the resection margins. Surgical specimens were orientated marking the superior edge with black ink and sent to a dedicated histopathologist. The comparison between the rates of positive margins at the definitive specimens after transoral resections in the present cohort and in a matched historical control group of 152 patients treated...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d49095f6fb0438df6fdd55c9bf6d352" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47285981,"asset_id":27022205,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47285981/download_file?st=MTczMjU1NTcyMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022205"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022205"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022205; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022205]").text(description); $(".js-view-count[data-work-id=27022205]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022205; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022205']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022205, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d49095f6fb0438df6fdd55c9bf6d352" } } $('.js-work-strip[data-work-id=27022205]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022205,"title":"Transoral Laser Microsurgery For Early Glottic Cancer: Intraoperative Narrow Band Imaging Delineates The Superficial Resection Margins","translated_title":"","metadata":{"abstract":"Objectives To investigate the impact of intraoperative examination with narrow band imaging (NBI) coupled to high definition television (HDTV) on the incidence of positive superficial resection margins in patients affected by early glottic cancers and treated by transoral laser microsurgery (TLM). Materials and Methods Between January 2012 and October 2013 a total of 82 previously untreated patients (70 males, 12 female; average age: 67 years) affected by glottic cancer (Tis andT1a) were treated with excision biopsy in term of type I or II endoscopic cordectomies according to the ELS classification. NBI-HDTV was routinely used intraoperatively to guide the resection margins. Surgical specimens were orientated marking the superior edge with black ink and sent to a dedicated histopathologist. The comparison between the rates of positive margins at the definitive specimens after transoral resections in the present cohort and in a matched historical control group of 152 patients treated..."},"translated_abstract":"Objectives To investigate the impact of intraoperative examination with narrow band imaging (NBI) coupled to high definition television (HDTV) on the incidence of positive superficial resection margins in patients affected by early glottic cancers and treated by transoral laser microsurgery (TLM). Materials and Methods Between January 2012 and October 2013 a total of 82 previously untreated patients (70 males, 12 female; average age: 67 years) affected by glottic cancer (Tis andT1a) were treated with excision biopsy in term of type I or II endoscopic cordectomies according to the ELS classification. NBI-HDTV was routinely used intraoperatively to guide the resection margins. Surgical specimens were orientated marking the superior edge with black ink and sent to a dedicated histopathologist. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022195"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022195/Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser"><img alt="Research paper thumbnail of Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022195/Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser">Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser</a></div><div class="wp-workCard_item"><span>Photomedicine and Laser Surgery</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prior to plasmonic photothermal therapy, involving heating of gold nanoparticles (GNPs) by laser,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prior to plasmonic photothermal therapy, involving heating of gold nanoparticles (GNPs) by laser, we explored some subcellular events that may threaten the viability of rat kidney cells (RKCs) incubated with GNPs irradiated with pulsed laser. We have previously shown a decrease in the viability of RKCs, on incubation with GNPs irradiated with pulsed laser. This decrease in viability was concomitant to a reduction in GNP diameter size, and reflected the occurrence of subcellular toxic events. After incubation of RKCs with GNPs irradiated with 532 nm pulsed laser (50 mJ/pulse energy, 5 ns duration, and 10 Hz repetition rate for 1, 3, and 5 min), we studied the cell membrane integrity, the induction of apoptosis, and the occurrence of oxidative stress. We reported the changes induced on RKCs by GNPs irradiated with pulsed laser and those induced on the same cells and after the same time intervals by unirradiated GNPs; both were related to a negative control. The decrease in viability of RKCs on incubation with GNPs irradiated with pulsed laser was shown to be mostly secondary to a cell membrane disruption, most probably related to the reduction in GNP diameter sizes. The oxidative stress exerted by smaller GNPs on RKCs, as well as the induction of apoptosis, seem to be tolerated by the RKCs. Irradiation of GNPs with pulsed laser, to elicit a plasmonic photothermal effect, reduces the GNPs&amp;amp;amp;amp;amp;amp;amp;#39; diameter. 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This decrease in viability was concomitant to a reduction in GNP diameter size, and reflected the occurrence of subcellular toxic events. After incubation of RKCs with GNPs irradiated with 532 nm pulsed laser (50 mJ/pulse energy, 5 ns duration, and 10 Hz repetition rate for 1, 3, and 5 min), we studied the cell membrane integrity, the induction of apoptosis, and the occurrence of oxidative stress. We reported the changes induced on RKCs by GNPs irradiated with pulsed laser and those induced on the same cells and after the same time intervals by unirradiated GNPs; both were related to a negative control. The decrease in viability of RKCs on incubation with GNPs irradiated with pulsed laser was shown to be mostly secondary to a cell membrane disruption, most probably related to the reduction in GNP diameter sizes. The oxidative stress exerted by smaller GNPs on RKCs, as well as the induction of apoptosis, seem to be tolerated by the RKCs. Irradiation of GNPs with pulsed laser, to elicit a plasmonic photothermal effect, reduces the GNPs\u0026amp;amp;amp;amp;amp;amp;amp;#39; diameter. The smaller-sized GNPs may lead to lethal cell membrane disruption in healthy RKCs.","internal_url":"https://www.academia.edu/27022195/Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser","translated_internal_url":"","created_at":"2016-07-15T22:51:11.215-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443038,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010111,"email":"m***r@gmail.com","display_order":0,"name":"Mahmoud Abdelhamid","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"},{"id":22443040,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010112,"email":"h***h@yahoo.com","display_order":4194304,"name":"Shimaa Abdelhamid","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"},{"id":22443042,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010113,"email":"a***r@usaid.gov","display_order":6291456,"name":"Adel Gohar","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"},{"id":22443058,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":3782491,"email":"t***f@niles.edu.eg","display_order":7340032,"name":"Tareq Youssef","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"}],"downloadable_attachments":[],"slug":"Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":35056,"name":"Metal Nanoparticles","url":"https://www.academia.edu/Documents/in/Metal_Nanoparticles"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":76736,"name":"Gold","url":"https://www.academia.edu/Documents/in/Gold"},{"id":80221,"name":"Lasers","url":"https://www.academia.edu/Documents/in/Lasers"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022194/Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser"><img alt="Research paper thumbnail of Excision Biopsy of Tongue Lesions by Diode Laser" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022194/Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser">Excision Biopsy of Tongue Lesions by Diode Laser</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/HazemSaleh">Hazem Saleh</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/AliSaafan">Ali Saafan</a></span></div><div class="wp-workCard_item"><span>Photomedicine and Laser Surgery</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to evaluate the diode laser in excision biopsy of superficial prolifera...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to evaluate the diode laser in excision biopsy of superficial proliferative tongue lesions under local anesthesia. Most mobile tongue lesions present as surface projections and have similar clinical features. They are usually excised for diagnostic purposes using conventional surgery or electrosurgery. The diode laser has proven itself useful in different oral surgeries. We report the results of a prospective pilot study where contact diode laser was used in excision biopsy of six mobile tongue lesions. All excised tissues were pathologically examined. To assess post-operative pain, patients were asked to correlate it to an 11-point Visual Analogue Scale (VAS); patients were also asked to assess their impression of alteration in tongue size on a 4-point scale. Healing, functional results, and recurrence rate were assessed. All interventions were uneventful and done at the same out-patient setting. All lesions were benign. Healing occurred by secondary intention in the six cases with no residual ulceration. Postoperative pain was mild in four cases, while two cases suffered from moderate pain. Post-operative impression of tongue swelling occurred in all cases. The mild impression disappeared by the end of the first week and the moderate one by the end of the second week. No recurrence was observed over a mean follow-up period of 15 months. The diode 980-nm laser is optimal for excision biopsy of superficial and benign proliferative lesions of the mobile tongue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022194]").text(description); $(".js-view-count[data-work-id=27022194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022194, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022194,"title":"Excision Biopsy of Tongue Lesions by Diode Laser","translated_title":"","metadata":{"abstract":"The aim of this study was to evaluate the diode laser in excision biopsy of superficial proliferative tongue lesions under local anesthesia. Most mobile tongue lesions present as surface projections and have similar clinical features. They are usually excised for diagnostic purposes using conventional surgery or electrosurgery. The diode laser has proven itself useful in different oral surgeries. We report the results of a prospective pilot study where contact diode laser was used in excision biopsy of six mobile tongue lesions. All excised tissues were pathologically examined. To assess post-operative pain, patients were asked to correlate it to an 11-point Visual Analogue Scale (VAS); patients were also asked to assess their impression of alteration in tongue size on a 4-point scale. Healing, functional results, and recurrence rate were assessed. All interventions were uneventful and done at the same out-patient setting. All lesions were benign. Healing occurred by secondary intention in the six cases with no residual ulceration. Postoperative pain was mild in four cases, while two cases suffered from moderate pain. Post-operative impression of tongue swelling occurred in all cases. The mild impression disappeared by the end of the first week and the moderate one by the end of the second week. No recurrence was observed over a mean follow-up period of 15 months. The diode 980-nm laser is optimal for excision biopsy of superficial and benign proliferative lesions of the mobile tongue.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Photomedicine and Laser Surgery"},"translated_abstract":"The aim of this study was to evaluate the diode laser in excision biopsy of superficial proliferative tongue lesions under local anesthesia. Most mobile tongue lesions present as surface projections and have similar clinical features. They are usually excised for diagnostic purposes using conventional surgery or electrosurgery. The diode laser has proven itself useful in different oral surgeries. We report the results of a prospective pilot study where contact diode laser was used in excision biopsy of six mobile tongue lesions. All excised tissues were pathologically examined. To assess post-operative pain, patients were asked to correlate it to an 11-point Visual Analogue Scale (VAS); patients were also asked to assess their impression of alteration in tongue size on a 4-point scale. Healing, functional results, and recurrence rate were assessed. All interventions were uneventful and done at the same out-patient setting. All lesions were benign. Healing occurred by secondary intention in the six cases with no residual ulceration. Postoperative pain was mild in four cases, while two cases suffered from moderate pain. Post-operative impression of tongue swelling occurred in all cases. The mild impression disappeared by the end of the first week and the moderate one by the end of the second week. No recurrence was observed over a mean follow-up period of 15 months. The diode 980-nm laser is optimal for excision biopsy of superficial and benign proliferative lesions of the mobile tongue.","internal_url":"https://www.academia.edu/27022194/Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser","translated_internal_url":"","created_at":"2016-07-15T22:51:11.052-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443060,"work_id":27022194,"tagging_user_id":51052825,"tagged_user_id":51088800,"co_author_invite_id":603659,"email":"a***n@yahoo.com","affiliation":"Cairo University","display_order":0,"name":"Ali Saafan","title":"Excision Biopsy of Tongue Lesions by Diode Laser"}],"downloadable_attachments":[],"slug":"Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":587541,"name":"Tongue Diseases","url":"https://www.academia.edu/Documents/in/Tongue_Diseases"},{"id":591063,"name":"Diode Laser","url":"https://www.academia.edu/Documents/in/Diode_Laser"},{"id":591484,"name":"Laser Therapy","url":"https://www.academia.edu/Documents/in/Laser_Therapy"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022193"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022193/Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers"><img alt="Research paper thumbnail of Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022193/Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers">Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/HazemSaleh">Hazem Saleh</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/AliSaafan">Ali Saafan</a></span></div><div class="wp-workCard_item"><span>Photomedicine and Laser Surgery</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During latency, the virus has no impact on infected cells. However, internal or external stimuli, including certain lasers, can induce virus reactivation. The aim was to study the reactivation power of the low-intensity diode and CO(2) lasers on the latent herpes virus. The bovine herpesvirus 1 (BHV-1) was inoculated in either the nasal cavity or the lacrimal film of an animal model. Once the virus entered into latency, the trigeminal ganglia of animals were exposed to either a low-intensity diode or CO(2) laser. The reactivation of the virus was then explored by PCR, RT-PCR, and dot-blot hybridization on nasal or lacrimal swabs. The accuracy, sensitivity, and specificity of the aforementioned techniques were compared. The low-intensity diode laser reactivated the herpes virus less than the CO(2) laser. The nasally inoculated virus was more liable for reactivation by both lasers. PCR was considered as the standard method for the detection of the reactivated virus. Low-intensity diode and CO(2) lasers can induce herpes virus reactivation, with the diode laser less likely to reactivate the virus than the CO(2) laser.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022193"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022193"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022193; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022193]").text(description); $(".js-view-count[data-work-id=27022193]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022193; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022193']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022193, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022193]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022193,"title":"Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers","translated_title":"","metadata":{"abstract":"The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During latency, the virus has no impact on infected cells. However, internal or external stimuli, including certain lasers, can induce virus reactivation. The aim was to study the reactivation power of the low-intensity diode and CO(2) lasers on the latent herpes virus. The bovine herpesvirus 1 (BHV-1) was inoculated in either the nasal cavity or the lacrimal film of an animal model. Once the virus entered into latency, the trigeminal ganglia of animals were exposed to either a low-intensity diode or CO(2) laser. The reactivation of the virus was then explored by PCR, RT-PCR, and dot-blot hybridization on nasal or lacrimal swabs. The accuracy, sensitivity, and specificity of the aforementioned techniques were compared. The low-intensity diode laser reactivated the herpes virus less than the CO(2) laser. The nasally inoculated virus was more liable for reactivation by both lasers. PCR was considered as the standard method for the detection of the reactivated virus. Low-intensity diode and CO(2) lasers can induce herpes virus reactivation, with the diode laser less likely to reactivate the virus than the CO(2) laser.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Photomedicine and Laser Surgery"},"translated_abstract":"The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During latency, the virus has no impact on infected cells. However, internal or external stimuli, including certain lasers, can induce virus reactivation. The aim was to study the reactivation power of the low-intensity diode and CO(2) lasers on the latent herpes virus. The bovine herpesvirus 1 (BHV-1) was inoculated in either the nasal cavity or the lacrimal film of an animal model. Once the virus entered into latency, the trigeminal ganglia of animals were exposed to either a low-intensity diode or CO(2) laser. The reactivation of the virus was then explored by PCR, RT-PCR, and dot-blot hybridization on nasal or lacrimal swabs. The accuracy, sensitivity, and specificity of the aforementioned techniques were compared. The low-intensity diode laser reactivated the herpes virus less than the CO(2) laser. The nasally inoculated virus was more liable for reactivation by both lasers. PCR was considered as the standard method for the detection of the reactivated virus. Low-intensity diode and CO(2) lasers can induce herpes virus reactivation, with the diode laser less likely to reactivate the virus than the CO(2) laser.","internal_url":"https://www.academia.edu/27022193/Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers","translated_internal_url":"","created_at":"2016-07-15T22:51:10.894-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443046,"work_id":27022193,"tagging_user_id":51052825,"tagged_user_id":155142283,"co_author_invite_id":5010116,"email":"a***l@gmail.com","display_order":4194304,"name":"عادل خليل","title":"Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers"},{"id":22443059,"work_id":27022193,"tagging_user_id":51052825,"tagged_user_id":51088800,"co_author_invite_id":603659,"email":"a***n@yahoo.com","affiliation":"Cairo University","display_order":6291456,"name":"Ali Saafan","title":"Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers"}],"downloadable_attachments":[],"slug":"Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":142495,"name":"Veterinary Laser Surgery","url":"https://www.academia.edu/Documents/in/Veterinary_Laser_Surgery"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022192/Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect"><img alt="Research paper thumbnail of Laser-induced modifications of gold nanoparticles and their cytotoxic effect" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022192/Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect">Laser-induced modifications of gold nanoparticles and their cytotoxic effect</a></div><div class="wp-workCard_item"><span>Journal of Biomedical Optics</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As nanotechnology continues to develop, an assessment of nanoparticles&amp;amp;amp;amp;amp;amp;am...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As nanotechnology continues to develop, an assessment of nanoparticles&amp;amp;amp;amp;amp;amp;amp;#39; toxicity becomes very crucial for biomedical applications. The current study examines the deleterious effects of pre-irradiated gold nanoparticles (GNPs) solutions on primary rat kidney cells (PRKCs). Spectroscopic and transmission electron microscopic studies demonstrated that exposure of 15 nm GNPs in size to pulsed laser caused a reduction both in optical density and mean particle diameter. GNPs showed an aggregation when added to the cell culture medium (DMEM). This aggregation was markedly decreased upon adding serum to the medium. Under our experimental conditions, trypan blue and MTT assays revealed no significant changes in cell viability when PRKCs were incubated with non-irradiated GNPs over a period of 72 h and up to 4 nM GNPs concentration. On the contrary, when cells were incubated with irradiated GNPs a significant reduction in PRKCs viability was revealed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022192]").text(description); $(".js-view-count[data-work-id=27022192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022192, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022192,"title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect","translated_title":"","metadata":{"abstract":"As nanotechnology continues to develop, an assessment of nanoparticles\u0026amp;amp;amp;amp;amp;amp;amp;#39; toxicity becomes very crucial for biomedical applications. The current study examines the deleterious effects of pre-irradiated gold nanoparticles (GNPs) solutions on primary rat kidney cells (PRKCs). Spectroscopic and transmission electron microscopic studies demonstrated that exposure of 15 nm GNPs in size to pulsed laser caused a reduction both in optical density and mean particle diameter. GNPs showed an aggregation when added to the cell culture medium (DMEM). This aggregation was markedly decreased upon adding serum to the medium. Under our experimental conditions, trypan blue and MTT assays revealed no significant changes in cell viability when PRKCs were incubated with non-irradiated GNPs over a period of 72 h and up to 4 nM GNPs concentration. On the contrary, when cells were incubated with irradiated GNPs a significant reduction in PRKCs viability was revealed.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Journal of Biomedical Optics"},"translated_abstract":"As nanotechnology continues to develop, an assessment of nanoparticles\u0026amp;amp;amp;amp;amp;amp;amp;#39; toxicity becomes very crucial for biomedical applications. The current study examines the deleterious effects of pre-irradiated gold nanoparticles (GNPs) solutions on primary rat kidney cells (PRKCs). Spectroscopic and transmission electron microscopic studies demonstrated that exposure of 15 nm GNPs in size to pulsed laser caused a reduction both in optical density and mean particle diameter. GNPs showed an aggregation when added to the cell culture medium (DMEM). This aggregation was markedly decreased upon adding serum to the medium. Under our experimental conditions, trypan blue and MTT assays revealed no significant changes in cell viability when PRKCs were incubated with non-irradiated GNPs over a period of 72 h and up to 4 nM GNPs concentration. On the contrary, when cells were incubated with irradiated GNPs a significant reduction in PRKCs viability was revealed.","internal_url":"https://www.academia.edu/27022192/Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect","translated_internal_url":"","created_at":"2016-07-15T22:51:10.729-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443037,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010111,"email":"m***r@gmail.com","display_order":0,"name":"Mahmoud Abdelhamid","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"},{"id":22443039,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010112,"email":"h***h@yahoo.com","display_order":4194304,"name":"Shimaa Abdelhamid","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"},{"id":22443041,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010113,"email":"a***r@usaid.gov","display_order":6291456,"name":"Adel Gohar","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"},{"id":22443057,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":3782491,"email":"t***f@niles.edu.eg","display_order":7340032,"name":"Tareq Youssef","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"}],"downloadable_attachments":[],"slug":"Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":2184,"name":"Electron Microscopy","url":"https://www.academia.edu/Documents/in/Electron_Microscopy"},{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy"},{"id":17733,"name":"Nanotechnology","url":"https://www.academia.edu/Documents/in/Nanotechnology"},{"id":35056,"name":"Metal Nanoparticles","url":"https://www.academia.edu/Documents/in/Metal_Nanoparticles"},{"id":36237,"name":"Biomedical","url":"https://www.academia.edu/Documents/in/Biomedical"},{"id":39421,"name":"Phototherapy","url":"https://www.academia.edu/Documents/in/Phototherapy"},{"id":55983,"name":"Biomedical Optics","url":"https://www.academia.edu/Documents/in/Biomedical_Optics"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":76736,"name":"Gold","url":"https://www.academia.edu/Documents/in/Gold"},{"id":80221,"name":"Lasers","url":"https://www.academia.edu/Documents/in/Lasers"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":376275,"name":"Trypan Blue","url":"https://www.academia.edu/Documents/in/Trypan_Blue"},{"id":806503,"name":"Thiazoles","url":"https://www.academia.edu/Documents/in/Thiazoles"},{"id":957359,"name":"Culture Media","url":"https://www.academia.edu/Documents/in/Culture_Media"},{"id":1145520,"name":"Equipment Design","url":"https://www.academia.edu/Documents/in/Equipment_Design"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022191"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022191/Glutamate_transporters_in_the_guinea_pig_cochlea_partial_mRNA_sequences_cellular_expression_and_functional_implications"><img alt="Research paper thumbnail of Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications" class="work-thumbnail" src="https://attachments.academia-assets.com/47285976/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022191/Glutamate_transporters_in_the_guinea_pig_cochlea_partial_mRNA_sequences_cellular_expression_and_functional_implications">Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications</a></div><div class="wp-workCard_item"><span>European Journal of Neuroscience</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f86af6ad08df7dc84571236386f437ab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47285976,"asset_id":27022191,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47285976/download_file?st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022191; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f86af6ad08df7dc84571236386f437ab" } } $('.js-work-strip[data-work-id=27022191]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022191,"title":"Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications","translated_title":"","metadata":{"grobid_abstract":"In the cochlea, glutamate plays a major role in synaptic transmission between the inner hair cell and the primary auditory neurons. Extracellular glutamate concentration must be regulated to prevent excitotoxicity. This regulation is mediated by excitatory amino acid transporters, membrane proteins that remove glutamate from the synaptic cleft. In this study, we investigated the distribution and activity of three excitatory amino acid transporters subtypes in the guinea-pig cochlea: glutamate aspartate transporter, glutamate transporter and excitatory amino acid carrier. A partial messenger ribonucleic acid sequence was determined for each of these transporters, by polymerase chain reaction with degenerate primers, using guinea-pig brain complementary deoxyribonucleic acid as the template. Primers specific for each transporter were then designed and used to screen a dissected organ of Corti complementary deoxyribonucleic acid library. The cellular distribution of each transporter was examined by immunocytochemistry. We investigated the functional consequences of inhibiting glutamate uptake by recording cochlear potentials during intracochlear perfusion with either L-trans-pyrrolidine-2,4-dicarboxylic acid or dihydrokainate. At the end of the electrophysiological session, cochleas were processed for electron microscopy. Only the glutamate aspartate transporter messenger ribonucleic acid was detected in the organ of Corti. Consistently, glutamate aspartate transporter protein was detected in the inner hair cell-supporting cells and in the ganglion of Corti satellite cells. Glutamate transporter and excitatory amino acid carrier were found in the afferent auditory neurons. Only intracochlear perfusions with L-trans-pyrrolidine-2,4-dicarboxylic acid resulted in a dose-dependent decrease in the amplitude of the cochlear compound action potential, leaving cochlear microphonic potential unaffected. After L-trans-pyrrolidine-2,4-dicarboxylic acid perfusion, cochleas displayed a swelling of the afferent endings typical of excitotoxicity. [(-)1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-4,5-dihydro-3-methylcarbamyl-2,3-benzodiazepine], a selective a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist protects the cochlea against L-trans-pyrrolidine-2,4-dicarboxylic acid effect. review, see . A dysfunction of glutamate transporter activity may aggravate damage to the cochlea. In this study, we investigated the expression of GLAST, GLT-1 and EAAC1 mRNA and their protein distribution in the adult guinea-pig cochlea. We also","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"European Journal of Neuroscience","grobid_abstract_attachment_id":47285976},"translated_abstract":null,"internal_url":"https://www.academia.edu/27022191/Glutamate_transporters_in_the_guinea_pig_cochlea_partial_mRNA_sequences_cellular_expression_and_functional_implications","translated_internal_url":"","created_at":"2016-07-15T22:51:10.578-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443061,"work_id":27022191,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":507479,"email":"j***e@rufford.org","display_order":0,"name":"J. Raymond","title":"Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications"},{"id":22443062,"work_id":27022191,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":3452181,"email":"j***l@cmapx.polytechnique.fr","display_order":4194304,"name":"J. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022189/Laryngeal_chondrosarcoma_a_report_of_five_cases"><img alt="Research paper thumbnail of Laryngeal chondrosarcoma: a report of five cases" class="work-thumbnail" src="https://attachments.academia-assets.com/47285979/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022189/Laryngeal_chondrosarcoma_a_report_of_five_cases">Laryngeal chondrosarcoma: a report of five cases</a></div><div class="wp-workCard_item"><span>European Archives of Oto-Rhino-Laryngology</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="207386a3766be98fd7cb4f2a1c23379b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47285979,"asset_id":27022189,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47285979/download_file?st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022189; 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According to the actually adopted classification, 95% of the reported cases are of a low-grade type. A consensus recognizing conservative surgery as the most reasonable treatment for these lesions has almost been reached. However, fear of jeopardizing the patency of the laryngeal airway as a result of a wide cricoid excision and also the fear of repeated recurrences could still push some surgeons to perform a total laryngectomy in the case of laryngeal chondrosarcoma. After a brief review of the literature, we will present five cases of laryngeal chondrosarcoma that were treated and followed at the Clermont-Ferrand University Medical Center over the last two decades. These cases exhibit many of the clinicopathologic features of the tumor and illustrate the pitfalls of diagnosis and treatment. In light of this presentation, we will discuss the widely accepted management as well as a newly suggested treatment modality for this disease.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"European Archives of Oto-Rhino-Laryngology","grobid_abstract_attachment_id":47285979},"translated_abstract":null,"internal_url":"https://www.academia.edu/27022189/Laryngeal_chondrosarcoma_a_report_of_five_cases","translated_internal_url":"","created_at":"2016-07-15T22:51:10.400-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443044,"work_id":27022189,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010114,"email":"c***d@ec.europa.eu","display_order":0,"name":"Christophe Guichard","title":"Laryngeal chondrosarcoma: a report of five cases"},{"id":22443050,"work_id":27022189,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010118,"email":"l***n@u-clermont1.fr","display_order":4194304,"name":"L. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="5517576" id="papers"><div class="js-work-strip profile--work_container" data-work-id="27022206"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022206/%EC%9D%B8%EA%B3%B5%EC%8A%B5%EC%A7%80%EC%9D%98_%EC%A1%B0%EC%84%B1%EB%B0%A9%EC%95%88_%EC%99%B8%EA%B5%AD%EC%9D%98_%EC%82%AC%EB%A1%80%EC%99%80_%ED%95%9C%EA%B5%AD%EC%97%90%EC%9D%98_%EC%A0%81%EC%9A%A9%EC%84%B1"><img alt="Research paper thumbnail of 인공습지의 조성방안 : 외국의 사례와 한국에의 적용성" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022206/%EC%9D%B8%EA%B3%B5%EC%8A%B5%EC%A7%80%EC%9D%98_%EC%A1%B0%EC%84%B1%EB%B0%A9%EC%95%88_%EC%99%B8%EA%B5%AD%EC%9D%98_%EC%82%AC%EB%A1%80%EC%99%80_%ED%95%9C%EA%B5%AD%EC%97%90%EC%9D%98_%EC%A0%81%EC%9A%A9%EC%84%B1">인공습지의 조성방안 : 외국의 사례와 한국에의 적용성</a></div><div class="wp-workCard_item"><span>2001년도 공동추계 학술발표회 논문집</span><span>, 2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022206"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022206"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022206; 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Kim","title":"인공습지의 조성방안 : 외국의 사례와 한국에의 적용성"}],"downloadable_attachments":[],"slug":"인공습지의_조성방안_외국의_사례와_한국에의_적용성","translated_slug":"","page_count":null,"language":"ko","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[],"urls":[{"id":7328465,"url":"http://www.auric.or.kr/User/Rdoc/DocRdoc.aspx?returnVal=RD_R\u0026dn=196108"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022205"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022205/Transoral_Laser_Microsurgery_For_Early_Glottic_Cancer_Intraoperative_Narrow_Band_Imaging_Delineates_The_Superficial_Resection_Margins"><img alt="Research paper thumbnail of Transoral Laser Microsurgery For Early Glottic Cancer: Intraoperative Narrow Band Imaging Delineates The Superficial Resection Margins" class="work-thumbnail" src="https://attachments.academia-assets.com/47285981/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022205/Transoral_Laser_Microsurgery_For_Early_Glottic_Cancer_Intraoperative_Narrow_Band_Imaging_Delineates_The_Superficial_Resection_Margins">Transoral Laser Microsurgery For Early Glottic Cancer: Intraoperative Narrow Band Imaging Delineates The Superficial Resection Margins</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives To investigate the impact of intraoperative examination with narrow band imaging (NBI)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives To investigate the impact of intraoperative examination with narrow band imaging (NBI) coupled to high definition television (HDTV) on the incidence of positive superficial resection margins in patients affected by early glottic cancers and treated by transoral laser microsurgery (TLM). Materials and Methods Between January 2012 and October 2013 a total of 82 previously untreated patients (70 males, 12 female; average age: 67 years) affected by glottic cancer (Tis andT1a) were treated with excision biopsy in term of type I or II endoscopic cordectomies according to the ELS classification. NBI-HDTV was routinely used intraoperatively to guide the resection margins. Surgical specimens were orientated marking the superior edge with black ink and sent to a dedicated histopathologist. The comparison between the rates of positive margins at the definitive specimens after transoral resections in the present cohort and in a matched historical control group of 152 patients treated...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d49095f6fb0438df6fdd55c9bf6d352" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47285981,"asset_id":27022205,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47285981/download_file?st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&st=MTczMjU1NTcyMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022205"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022205"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022205; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022205]").text(description); $(".js-view-count[data-work-id=27022205]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022205; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022205']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022205, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5d49095f6fb0438df6fdd55c9bf6d352" } } $('.js-work-strip[data-work-id=27022205]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022205,"title":"Transoral Laser Microsurgery For Early Glottic Cancer: Intraoperative Narrow Band Imaging Delineates The Superficial Resection Margins","translated_title":"","metadata":{"abstract":"Objectives To investigate the impact of intraoperative examination with narrow band imaging (NBI) coupled to high definition television (HDTV) on the incidence of positive superficial resection margins in patients affected by early glottic cancers and treated by transoral laser microsurgery (TLM). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022196"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022196/Neurosurgical_Complications"><img alt="Research paper thumbnail of Neurosurgical Complications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022196/Neurosurgical_Complications">Neurosurgical Complications</a></div><div class="wp-workCard_item"><span>Complications in Head and Neck Surgery</span><span>, 2009</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022196"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022196"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022196; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022196]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022196,"title":"Neurosurgical Complications","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"publication_name":"Complications in Head and Neck Surgery"},"translated_abstract":null,"internal_url":"https://www.academia.edu/27022196/Neurosurgical_Complications","translated_internal_url":"","created_at":"2016-07-15T22:51:11.363-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443052,"work_id":27022196,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010119,"email":"m***t@qmul.ac.uk","display_order":0,"name":"Michael McDermott","title":"Neurosurgical Complications"},{"id":22443055,"work_id":27022196,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010120,"email":"m***m@phas.ubc.ca","display_order":4194304,"name":"Michael McDermott","title":"Neurosurgical Complications"}],"downloadable_attachments":[],"slug":"Neurosurgical_Complications","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022195"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022195/Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser"><img alt="Research paper thumbnail of Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022195/Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser">Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser</a></div><div class="wp-workCard_item"><span>Photomedicine and Laser Surgery</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Prior to plasmonic photothermal therapy, involving heating of gold nanoparticles (GNPs) by laser,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Prior to plasmonic photothermal therapy, involving heating of gold nanoparticles (GNPs) by laser, we explored some subcellular events that may threaten the viability of rat kidney cells (RKCs) incubated with GNPs irradiated with pulsed laser. We have previously shown a decrease in the viability of RKCs, on incubation with GNPs irradiated with pulsed laser. This decrease in viability was concomitant to a reduction in GNP diameter size, and reflected the occurrence of subcellular toxic events. After incubation of RKCs with GNPs irradiated with 532 nm pulsed laser (50 mJ/pulse energy, 5 ns duration, and 10 Hz repetition rate for 1, 3, and 5 min), we studied the cell membrane integrity, the induction of apoptosis, and the occurrence of oxidative stress. We reported the changes induced on RKCs by GNPs irradiated with pulsed laser and those induced on the same cells and after the same time intervals by unirradiated GNPs; both were related to a negative control. The decrease in viability of RKCs on incubation with GNPs irradiated with pulsed laser was shown to be mostly secondary to a cell membrane disruption, most probably related to the reduction in GNP diameter sizes. The oxidative stress exerted by smaller GNPs on RKCs, as well as the induction of apoptosis, seem to be tolerated by the RKCs. Irradiation of GNPs with pulsed laser, to elicit a plasmonic photothermal effect, reduces the GNPs&amp;amp;amp;amp;amp;amp;amp;#39; diameter. The smaller-sized GNPs may lead to lethal cell membrane disruption in healthy RKCs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022195"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022195"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022195; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022195]").text(description); $(".js-view-count[data-work-id=27022195]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022195; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022195']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022195, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022195]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022195,"title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser","translated_title":"","metadata":{"abstract":"Prior to plasmonic photothermal therapy, involving heating of gold nanoparticles (GNPs) by laser, we explored some subcellular events that may threaten the viability of rat kidney cells (RKCs) incubated with GNPs irradiated with pulsed laser. We have previously shown a decrease in the viability of RKCs, on incubation with GNPs irradiated with pulsed laser. This decrease in viability was concomitant to a reduction in GNP diameter size, and reflected the occurrence of subcellular toxic events. After incubation of RKCs with GNPs irradiated with 532 nm pulsed laser (50 mJ/pulse energy, 5 ns duration, and 10 Hz repetition rate for 1, 3, and 5 min), we studied the cell membrane integrity, the induction of apoptosis, and the occurrence of oxidative stress. We reported the changes induced on RKCs by GNPs irradiated with pulsed laser and those induced on the same cells and after the same time intervals by unirradiated GNPs; both were related to a negative control. The decrease in viability of RKCs on incubation with GNPs irradiated with pulsed laser was shown to be mostly secondary to a cell membrane disruption, most probably related to the reduction in GNP diameter sizes. The oxidative stress exerted by smaller GNPs on RKCs, as well as the induction of apoptosis, seem to be tolerated by the RKCs. Irradiation of GNPs with pulsed laser, to elicit a plasmonic photothermal effect, reduces the GNPs\u0026amp;amp;amp;amp;amp;amp;amp;#39; diameter. The smaller-sized GNPs may lead to lethal cell membrane disruption in healthy RKCs.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Photomedicine and Laser Surgery"},"translated_abstract":"Prior to plasmonic photothermal therapy, involving heating of gold nanoparticles (GNPs) by laser, we explored some subcellular events that may threaten the viability of rat kidney cells (RKCs) incubated with GNPs irradiated with pulsed laser. We have previously shown a decrease in the viability of RKCs, on incubation with GNPs irradiated with pulsed laser. This decrease in viability was concomitant to a reduction in GNP diameter size, and reflected the occurrence of subcellular toxic events. After incubation of RKCs with GNPs irradiated with 532 nm pulsed laser (50 mJ/pulse energy, 5 ns duration, and 10 Hz repetition rate for 1, 3, and 5 min), we studied the cell membrane integrity, the induction of apoptosis, and the occurrence of oxidative stress. We reported the changes induced on RKCs by GNPs irradiated with pulsed laser and those induced on the same cells and after the same time intervals by unirradiated GNPs; both were related to a negative control. The decrease in viability of RKCs on incubation with GNPs irradiated with pulsed laser was shown to be mostly secondary to a cell membrane disruption, most probably related to the reduction in GNP diameter sizes. The oxidative stress exerted by smaller GNPs on RKCs, as well as the induction of apoptosis, seem to be tolerated by the RKCs. Irradiation of GNPs with pulsed laser, to elicit a plasmonic photothermal effect, reduces the GNPs\u0026amp;amp;amp;amp;amp;amp;amp;#39; diameter. The smaller-sized GNPs may lead to lethal cell membrane disruption in healthy RKCs.","internal_url":"https://www.academia.edu/27022195/Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser","translated_internal_url":"","created_at":"2016-07-15T22:51:11.215-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443038,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010111,"email":"m***r@gmail.com","display_order":0,"name":"Mahmoud Abdelhamid","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"},{"id":22443040,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010112,"email":"h***h@yahoo.com","display_order":4194304,"name":"Shimaa Abdelhamid","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"},{"id":22443042,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010113,"email":"a***r@usaid.gov","display_order":6291456,"name":"Adel Gohar","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"},{"id":22443058,"work_id":27022195,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":3782491,"email":"t***f@niles.edu.eg","display_order":7340032,"name":"Tareq Youssef","title":"Subcellular Toxicity of Gold Nanoparticles Irradiated with 532 nm Pulsed Laser"}],"downloadable_attachments":[],"slug":"Subcellular_Toxicity_of_Gold_Nanoparticles_Irradiated_with_532_nm_Pulsed_Laser","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":35056,"name":"Metal Nanoparticles","url":"https://www.academia.edu/Documents/in/Metal_Nanoparticles"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":76736,"name":"Gold","url":"https://www.academia.edu/Documents/in/Gold"},{"id":80221,"name":"Lasers","url":"https://www.academia.edu/Documents/in/Lasers"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022194"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022194/Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser"><img alt="Research paper thumbnail of Excision Biopsy of Tongue Lesions by Diode Laser" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022194/Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser">Excision Biopsy of Tongue Lesions by Diode Laser</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/HazemSaleh">Hazem Saleh</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/AliSaafan">Ali Saafan</a></span></div><div class="wp-workCard_item"><span>Photomedicine and Laser Surgery</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to evaluate the diode laser in excision biopsy of superficial prolifera...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to evaluate the diode laser in excision biopsy of superficial proliferative tongue lesions under local anesthesia. Most mobile tongue lesions present as surface projections and have similar clinical features. They are usually excised for diagnostic purposes using conventional surgery or electrosurgery. The diode laser has proven itself useful in different oral surgeries. We report the results of a prospective pilot study where contact diode laser was used in excision biopsy of six mobile tongue lesions. All excised tissues were pathologically examined. To assess post-operative pain, patients were asked to correlate it to an 11-point Visual Analogue Scale (VAS); patients were also asked to assess their impression of alteration in tongue size on a 4-point scale. Healing, functional results, and recurrence rate were assessed. All interventions were uneventful and done at the same out-patient setting. All lesions were benign. Healing occurred by secondary intention in the six cases with no residual ulceration. Postoperative pain was mild in four cases, while two cases suffered from moderate pain. Post-operative impression of tongue swelling occurred in all cases. The mild impression disappeared by the end of the first week and the moderate one by the end of the second week. No recurrence was observed over a mean follow-up period of 15 months. The diode 980-nm laser is optimal for excision biopsy of superficial and benign proliferative lesions of the mobile tongue.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022194"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022194"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022194; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022194]").text(description); $(".js-view-count[data-work-id=27022194]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022194; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022194']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022194, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022194]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022194,"title":"Excision Biopsy of Tongue Lesions by Diode Laser","translated_title":"","metadata":{"abstract":"The aim of this study was to evaluate the diode laser in excision biopsy of superficial proliferative tongue lesions under local anesthesia. Most mobile tongue lesions present as surface projections and have similar clinical features. They are usually excised for diagnostic purposes using conventional surgery or electrosurgery. The diode laser has proven itself useful in different oral surgeries. We report the results of a prospective pilot study where contact diode laser was used in excision biopsy of six mobile tongue lesions. All excised tissues were pathologically examined. To assess post-operative pain, patients were asked to correlate it to an 11-point Visual Analogue Scale (VAS); patients were also asked to assess their impression of alteration in tongue size on a 4-point scale. Healing, functional results, and recurrence rate were assessed. All interventions were uneventful and done at the same out-patient setting. All lesions were benign. Healing occurred by secondary intention in the six cases with no residual ulceration. Postoperative pain was mild in four cases, while two cases suffered from moderate pain. Post-operative impression of tongue swelling occurred in all cases. The mild impression disappeared by the end of the first week and the moderate one by the end of the second week. No recurrence was observed over a mean follow-up period of 15 months. The diode 980-nm laser is optimal for excision biopsy of superficial and benign proliferative lesions of the mobile tongue.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"Photomedicine and Laser Surgery"},"translated_abstract":"The aim of this study was to evaluate the diode laser in excision biopsy of superficial proliferative tongue lesions under local anesthesia. Most mobile tongue lesions present as surface projections and have similar clinical features. They are usually excised for diagnostic purposes using conventional surgery or electrosurgery. The diode laser has proven itself useful in different oral surgeries. We report the results of a prospective pilot study where contact diode laser was used in excision biopsy of six mobile tongue lesions. All excised tissues were pathologically examined. To assess post-operative pain, patients were asked to correlate it to an 11-point Visual Analogue Scale (VAS); patients were also asked to assess their impression of alteration in tongue size on a 4-point scale. Healing, functional results, and recurrence rate were assessed. All interventions were uneventful and done at the same out-patient setting. All lesions were benign. Healing occurred by secondary intention in the six cases with no residual ulceration. Postoperative pain was mild in four cases, while two cases suffered from moderate pain. Post-operative impression of tongue swelling occurred in all cases. The mild impression disappeared by the end of the first week and the moderate one by the end of the second week. No recurrence was observed over a mean follow-up period of 15 months. The diode 980-nm laser is optimal for excision biopsy of superficial and benign proliferative lesions of the mobile tongue.","internal_url":"https://www.academia.edu/27022194/Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser","translated_internal_url":"","created_at":"2016-07-15T22:51:11.052-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443060,"work_id":27022194,"tagging_user_id":51052825,"tagged_user_id":51088800,"co_author_invite_id":603659,"email":"a***n@yahoo.com","affiliation":"Cairo University","display_order":0,"name":"Ali Saafan","title":"Excision Biopsy of Tongue Lesions by Diode Laser"}],"downloadable_attachments":[],"slug":"Excision_Biopsy_of_Tongue_Lesions_by_Diode_Laser","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":37826,"name":"Biopsy","url":"https://www.academia.edu/Documents/in/Biopsy"},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":587541,"name":"Tongue Diseases","url":"https://www.academia.edu/Documents/in/Tongue_Diseases"},{"id":591063,"name":"Diode Laser","url":"https://www.academia.edu/Documents/in/Diode_Laser"},{"id":591484,"name":"Laser Therapy","url":"https://www.academia.edu/Documents/in/Laser_Therapy"},{"id":945595,"name":"Pilot Projects","url":"https://www.academia.edu/Documents/in/Pilot_Projects"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022193"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022193/Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers"><img alt="Research paper thumbnail of Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022193/Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers">Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/HazemSaleh">Hazem Saleh</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://cairo.academia.edu/AliSaafan">Ali Saafan</a></span></div><div class="wp-workCard_item"><span>Photomedicine and Laser Surgery</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During latency, the virus has no impact on infected cells. However, internal or external stimuli, including certain lasers, can induce virus reactivation. The aim was to study the reactivation power of the low-intensity diode and CO(2) lasers on the latent herpes virus. The bovine herpesvirus 1 (BHV-1) was inoculated in either the nasal cavity or the lacrimal film of an animal model. Once the virus entered into latency, the trigeminal ganglia of animals were exposed to either a low-intensity diode or CO(2) laser. The reactivation of the virus was then explored by PCR, RT-PCR, and dot-blot hybridization on nasal or lacrimal swabs. The accuracy, sensitivity, and specificity of the aforementioned techniques were compared. The low-intensity diode laser reactivated the herpes virus less than the CO(2) laser. The nasally inoculated virus was more liable for reactivation by both lasers. PCR was considered as the standard method for the detection of the reactivated virus. Low-intensity diode and CO(2) lasers can induce herpes virus reactivation, with the diode laser less likely to reactivate the virus than the CO(2) laser.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022193"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022193"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022193; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022193]").text(description); $(".js-view-count[data-work-id=27022193]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022193; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022193']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022193, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022193]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022193,"title":"Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers","translated_title":"","metadata":{"abstract":"The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During latency, the virus has no impact on infected cells. However, internal or external stimuli, including certain lasers, can induce virus reactivation. The aim was to study the reactivation power of the low-intensity diode and CO(2) lasers on the latent herpes virus. The bovine herpesvirus 1 (BHV-1) was inoculated in either the nasal cavity or the lacrimal film of an animal model. Once the virus entered into latency, the trigeminal ganglia of animals were exposed to either a low-intensity diode or CO(2) laser. The reactivation of the virus was then explored by PCR, RT-PCR, and dot-blot hybridization on nasal or lacrimal swabs. The accuracy, sensitivity, and specificity of the aforementioned techniques were compared. The low-intensity diode laser reactivated the herpes virus less than the CO(2) laser. The nasally inoculated virus was more liable for reactivation by both lasers. PCR was considered as the standard method for the detection of the reactivated virus. Low-intensity diode and CO(2) lasers can induce herpes virus reactivation, with the diode laser less likely to reactivate the virus than the CO(2) laser.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Photomedicine and Laser Surgery"},"translated_abstract":"The herpes virus enters into latency after symptomatic or asymptomatic herpetic infection. During latency, the virus has no impact on infected cells. However, internal or external stimuli, including certain lasers, can induce virus reactivation. The aim was to study the reactivation power of the low-intensity diode and CO(2) lasers on the latent herpes virus. The bovine herpesvirus 1 (BHV-1) was inoculated in either the nasal cavity or the lacrimal film of an animal model. Once the virus entered into latency, the trigeminal ganglia of animals were exposed to either a low-intensity diode or CO(2) laser. The reactivation of the virus was then explored by PCR, RT-PCR, and dot-blot hybridization on nasal or lacrimal swabs. The accuracy, sensitivity, and specificity of the aforementioned techniques were compared. The low-intensity diode laser reactivated the herpes virus less than the CO(2) laser. The nasally inoculated virus was more liable for reactivation by both lasers. PCR was considered as the standard method for the detection of the reactivated virus. Low-intensity diode and CO(2) lasers can induce herpes virus reactivation, with the diode laser less likely to reactivate the virus than the CO(2) laser.","internal_url":"https://www.academia.edu/27022193/Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers","translated_internal_url":"","created_at":"2016-07-15T22:51:10.894-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443046,"work_id":27022193,"tagging_user_id":51052825,"tagged_user_id":155142283,"co_author_invite_id":5010116,"email":"a***l@gmail.com","display_order":4194304,"name":"عادل خليل","title":"Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers"},{"id":22443059,"work_id":27022193,"tagging_user_id":51052825,"tagged_user_id":51088800,"co_author_invite_id":603659,"email":"a***n@yahoo.com","affiliation":"Cairo University","display_order":6291456,"name":"Ali Saafan","title":"Herpes Virus Reactivation by Low-Intensity Diode and CO 2 Lasers"}],"downloadable_attachments":[],"slug":"Herpes_Virus_Reactivation_by_Low_Intensity_Diode_and_CO_2_Lasers","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":142495,"name":"Veterinary Laser Surgery","url":"https://www.academia.edu/Documents/in/Veterinary_Laser_Surgery"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":788677,"name":"Rabbits","url":"https://www.academia.edu/Documents/in/Rabbits"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022192"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022192/Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect"><img alt="Research paper thumbnail of Laser-induced modifications of gold nanoparticles and their cytotoxic effect" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022192/Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect">Laser-induced modifications of gold nanoparticles and their cytotoxic effect</a></div><div class="wp-workCard_item"><span>Journal of Biomedical Optics</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As nanotechnology continues to develop, an assessment of nanoparticles&amp;amp;amp;amp;amp;amp;am...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As nanotechnology continues to develop, an assessment of nanoparticles&amp;amp;amp;amp;amp;amp;amp;#39; toxicity becomes very crucial for biomedical applications. The current study examines the deleterious effects of pre-irradiated gold nanoparticles (GNPs) solutions on primary rat kidney cells (PRKCs). Spectroscopic and transmission electron microscopic studies demonstrated that exposure of 15 nm GNPs in size to pulsed laser caused a reduction both in optical density and mean particle diameter. GNPs showed an aggregation when added to the cell culture medium (DMEM). This aggregation was markedly decreased upon adding serum to the medium. Under our experimental conditions, trypan blue and MTT assays revealed no significant changes in cell viability when PRKCs were incubated with non-irradiated GNPs over a period of 72 h and up to 4 nM GNPs concentration. On the contrary, when cells were incubated with irradiated GNPs a significant reduction in PRKCs viability was revealed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022192"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022192"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022192; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022192]").text(description); $(".js-view-count[data-work-id=27022192]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022192; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022192']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022192, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=27022192]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022192,"title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect","translated_title":"","metadata":{"abstract":"As nanotechnology continues to develop, an assessment of nanoparticles\u0026amp;amp;amp;amp;amp;amp;amp;#39; toxicity becomes very crucial for biomedical applications. The current study examines the deleterious effects of pre-irradiated gold nanoparticles (GNPs) solutions on primary rat kidney cells (PRKCs). Spectroscopic and transmission electron microscopic studies demonstrated that exposure of 15 nm GNPs in size to pulsed laser caused a reduction both in optical density and mean particle diameter. GNPs showed an aggregation when added to the cell culture medium (DMEM). This aggregation was markedly decreased upon adding serum to the medium. Under our experimental conditions, trypan blue and MTT assays revealed no significant changes in cell viability when PRKCs were incubated with non-irradiated GNPs over a period of 72 h and up to 4 nM GNPs concentration. On the contrary, when cells were incubated with irradiated GNPs a significant reduction in PRKCs viability was revealed.","publication_date":{"day":null,"month":null,"year":2012,"errors":{}},"publication_name":"Journal of Biomedical Optics"},"translated_abstract":"As nanotechnology continues to develop, an assessment of nanoparticles\u0026amp;amp;amp;amp;amp;amp;amp;#39; toxicity becomes very crucial for biomedical applications. The current study examines the deleterious effects of pre-irradiated gold nanoparticles (GNPs) solutions on primary rat kidney cells (PRKCs). Spectroscopic and transmission electron microscopic studies demonstrated that exposure of 15 nm GNPs in size to pulsed laser caused a reduction both in optical density and mean particle diameter. GNPs showed an aggregation when added to the cell culture medium (DMEM). This aggregation was markedly decreased upon adding serum to the medium. Under our experimental conditions, trypan blue and MTT assays revealed no significant changes in cell viability when PRKCs were incubated with non-irradiated GNPs over a period of 72 h and up to 4 nM GNPs concentration. On the contrary, when cells were incubated with irradiated GNPs a significant reduction in PRKCs viability was revealed.","internal_url":"https://www.academia.edu/27022192/Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect","translated_internal_url":"","created_at":"2016-07-15T22:51:10.729-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443037,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010111,"email":"m***r@gmail.com","display_order":0,"name":"Mahmoud Abdelhamid","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"},{"id":22443039,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010112,"email":"h***h@yahoo.com","display_order":4194304,"name":"Shimaa Abdelhamid","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"},{"id":22443041,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010113,"email":"a***r@usaid.gov","display_order":6291456,"name":"Adel Gohar","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"},{"id":22443057,"work_id":27022192,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":3782491,"email":"t***f@niles.edu.eg","display_order":7340032,"name":"Tareq Youssef","title":"Laser-induced modifications of gold nanoparticles and their cytotoxic effect"}],"downloadable_attachments":[],"slug":"Laser_induced_modifications_of_gold_nanoparticles_and_their_cytotoxic_effect","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[],"research_interests":[{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":2184,"name":"Electron Microscopy","url":"https://www.academia.edu/Documents/in/Electron_Microscopy"},{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy"},{"id":17733,"name":"Nanotechnology","url":"https://www.academia.edu/Documents/in/Nanotechnology"},{"id":35056,"name":"Metal Nanoparticles","url":"https://www.academia.edu/Documents/in/Metal_Nanoparticles"},{"id":36237,"name":"Biomedical","url":"https://www.academia.edu/Documents/in/Biomedical"},{"id":39421,"name":"Phototherapy","url":"https://www.academia.edu/Documents/in/Phototherapy"},{"id":55983,"name":"Biomedical Optics","url":"https://www.academia.edu/Documents/in/Biomedical_Optics"},{"id":71294,"name":"Kidney","url":"https://www.academia.edu/Documents/in/Kidney"},{"id":76736,"name":"Gold","url":"https://www.academia.edu/Documents/in/Gold"},{"id":80221,"name":"Lasers","url":"https://www.academia.edu/Documents/in/Lasers"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":376275,"name":"Trypan Blue","url":"https://www.academia.edu/Documents/in/Trypan_Blue"},{"id":806503,"name":"Thiazoles","url":"https://www.academia.edu/Documents/in/Thiazoles"},{"id":957359,"name":"Culture Media","url":"https://www.academia.edu/Documents/in/Culture_Media"},{"id":1145520,"name":"Equipment Design","url":"https://www.academia.edu/Documents/in/Equipment_Design"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022191"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022191/Glutamate_transporters_in_the_guinea_pig_cochlea_partial_mRNA_sequences_cellular_expression_and_functional_implications"><img alt="Research paper thumbnail of Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications" class="work-thumbnail" src="https://attachments.academia-assets.com/47285976/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022191/Glutamate_transporters_in_the_guinea_pig_cochlea_partial_mRNA_sequences_cellular_expression_and_functional_implications">Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications</a></div><div class="wp-workCard_item"><span>European Journal of Neuroscience</span><span>, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f86af6ad08df7dc84571236386f437ab" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47285976,"asset_id":27022191,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47285976/download_file?st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022191"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022191"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022191; 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Extracellular glutamate concentration must be regulated to prevent excitotoxicity. This regulation is mediated by excitatory amino acid transporters, membrane proteins that remove glutamate from the synaptic cleft. In this study, we investigated the distribution and activity of three excitatory amino acid transporters subtypes in the guinea-pig cochlea: glutamate aspartate transporter, glutamate transporter and excitatory amino acid carrier. A partial messenger ribonucleic acid sequence was determined for each of these transporters, by polymerase chain reaction with degenerate primers, using guinea-pig brain complementary deoxyribonucleic acid as the template. Primers specific for each transporter were then designed and used to screen a dissected organ of Corti complementary deoxyribonucleic acid library. The cellular distribution of each transporter was examined by immunocytochemistry. We investigated the functional consequences of inhibiting glutamate uptake by recording cochlear potentials during intracochlear perfusion with either L-trans-pyrrolidine-2,4-dicarboxylic acid or dihydrokainate. At the end of the electrophysiological session, cochleas were processed for electron microscopy. Only the glutamate aspartate transporter messenger ribonucleic acid was detected in the organ of Corti. Consistently, glutamate aspartate transporter protein was detected in the inner hair cell-supporting cells and in the ganglion of Corti satellite cells. Glutamate transporter and excitatory amino acid carrier were found in the afferent auditory neurons. Only intracochlear perfusions with L-trans-pyrrolidine-2,4-dicarboxylic acid resulted in a dose-dependent decrease in the amplitude of the cochlear compound action potential, leaving cochlear microphonic potential unaffected. After L-trans-pyrrolidine-2,4-dicarboxylic acid perfusion, cochleas displayed a swelling of the afferent endings typical of excitotoxicity. [(-)1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-4,5-dihydro-3-methylcarbamyl-2,3-benzodiazepine], a selective a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist protects the cochlea against L-trans-pyrrolidine-2,4-dicarboxylic acid effect. review, see . A dysfunction of glutamate transporter activity may aggravate damage to the cochlea. In this study, we investigated the expression of GLAST, GLT-1 and EAAC1 mRNA and their protein distribution in the adult guinea-pig cochlea. We also","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"European Journal of Neuroscience","grobid_abstract_attachment_id":47285976},"translated_abstract":null,"internal_url":"https://www.academia.edu/27022191/Glutamate_transporters_in_the_guinea_pig_cochlea_partial_mRNA_sequences_cellular_expression_and_functional_implications","translated_internal_url":"","created_at":"2016-07-15T22:51:10.578-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443061,"work_id":27022191,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":507479,"email":"j***e@rufford.org","display_order":0,"name":"J. Raymond","title":"Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications"},{"id":22443062,"work_id":27022191,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":3452181,"email":"j***l@cmapx.polytechnique.fr","display_order":4194304,"name":"J. Puel","title":"Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications"},{"id":22443070,"work_id":27022191,"tagging_user_id":51052825,"tagged_user_id":32440114,"co_author_invite_id":null,"email":"j***l@sbf.ulaval.ca","affiliation":"Université Laval","display_order":6291456,"name":"Jean-claude Ruel","title":"Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications"}],"downloadable_attachments":[{"id":47285976,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47285976/thumbnails/1.jpg","file_name":"00b495358c55c0953f000000.pdf","download_url":"https://www.academia.edu/attachments/47285976/download_file?st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Glutamate_transporters_in_the_guinea_pig.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47285976/00b495358c55c0953f000000-libre.pdf?1468733135=\u0026response-content-disposition=attachment%3B+filename%3DGlutamate_transporters_in_the_guinea_pig.pdf\u0026Expires=1732559324\u0026Signature=fG39FNEUogSEy3dP~2paj2jk11G3ZQNLE0sobDLwor9UPg3IJB2CPPTwNZmAhiHozx591HqfrKjt0DVYOHC~I1H5H8FBgjgVXreyxBuobU4u26YUdzICf34oe8DVwYQ69BH708LC3X8D5Q3pnyKnNAbSEKsOTQgyifExKGskKI2WGKCqI28oLsMdfNJLh9WjjlwN0s6BidzUdKRrZQGIbXXJ94~7UzRuAUDD4rkbmWiBfYskjE68OwMVTK~mhgM9L110Eq-7Da5-R2BzRPi--GEezhhQmZO1whmTDLRQWUfjxzKxPWO6omNWq2wLNJmGzq--VdyziBOsFIWl5hS6VA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Glutamate_transporters_in_the_guinea_pig_cochlea_partial_mRNA_sequences_cellular_expression_and_functional_implications","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":51052825,"first_name":"Hazem","middle_initials":null,"last_name":"Saleh","page_name":"HazemSaleh","domain_name":"cairo","created_at":"2016-07-15T22:48:15.879-07:00","display_name":"Hazem Saleh","url":"https://cairo.academia.edu/HazemSaleh"},"attachments":[{"id":47285976,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/47285976/thumbnails/1.jpg","file_name":"00b495358c55c0953f000000.pdf","download_url":"https://www.academia.edu/attachments/47285976/download_file?st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Glutamate_transporters_in_the_guinea_pig.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/47285976/00b495358c55c0953f000000-libre.pdf?1468733135=\u0026response-content-disposition=attachment%3B+filename%3DGlutamate_transporters_in_the_guinea_pig.pdf\u0026Expires=1732559324\u0026Signature=fG39FNEUogSEy3dP~2paj2jk11G3ZQNLE0sobDLwor9UPg3IJB2CPPTwNZmAhiHozx591HqfrKjt0DVYOHC~I1H5H8FBgjgVXreyxBuobU4u26YUdzICf34oe8DVwYQ69BH708LC3X8D5Q3pnyKnNAbSEKsOTQgyifExKGskKI2WGKCqI28oLsMdfNJLh9WjjlwN0s6BidzUdKRrZQGIbXXJ94~7UzRuAUDD4rkbmWiBfYskjE68OwMVTK~mhgM9L110Eq-7Da5-R2BzRPi--GEezhhQmZO1whmTDLRQWUfjxzKxPWO6omNWq2wLNJmGzq--VdyziBOsFIWl5hS6VA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology"},{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":2184,"name":"Electron Microscopy","url":"https://www.academia.edu/Documents/in/Electron_Microscopy"},{"id":12071,"name":"Immunohistochemistry","url":"https://www.academia.edu/Documents/in/Immunohistochemistry"},{"id":18533,"name":"Confocal Microscopy","url":"https://www.academia.edu/Documents/in/Confocal_Microscopy"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":118339,"name":"Polymerase Chain Reaction","url":"https://www.academia.edu/Documents/in/Polymerase_Chain_Reaction"},{"id":133351,"name":"Benzodiazepines","url":"https://www.academia.edu/Documents/in/Benzodiazepines"},{"id":167027,"name":"Dendrites","url":"https://www.academia.edu/Documents/in/Dendrites"},{"id":485556,"name":"Guinea Pig","url":"https://www.academia.edu/Documents/in/Guinea_Pig"},{"id":744772,"name":"organ of Corti","url":"https://www.academia.edu/Documents/in/organ_of_Corti"},{"id":1151963,"name":"Cochlea","url":"https://www.academia.edu/Documents/in/Cochlea"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"},{"id":1703757,"name":"Glutamate Transporter","url":"https://www.academia.edu/Documents/in/Glutamate_Transporter"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="27022189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/27022189/Laryngeal_chondrosarcoma_a_report_of_five_cases"><img alt="Research paper thumbnail of Laryngeal chondrosarcoma: a report of five cases" class="work-thumbnail" src="https://attachments.academia-assets.com/47285979/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/27022189/Laryngeal_chondrosarcoma_a_report_of_five_cases">Laryngeal chondrosarcoma: a report of five cases</a></div><div class="wp-workCard_item"><span>European Archives of Oto-Rhino-Laryngology</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="207386a3766be98fd7cb4f2a1c23379b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":47285979,"asset_id":27022189,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/47285979/download_file?st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&st=MTczMjU1NTcyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="27022189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="27022189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 27022189; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=27022189]").text(description); $(".js-view-count[data-work-id=27022189]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 27022189; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='27022189']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 27022189, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "207386a3766be98fd7cb4f2a1c23379b" } } $('.js-work-strip[data-work-id=27022189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":27022189,"title":"Laryngeal chondrosarcoma: a report of five cases","translated_title":"","metadata":{"grobid_abstract":"Laryngeal chondrosarcoma is a rare tumor that is known for its indolent course and its tendency to ultimate recurrence. According to the actually adopted classification, 95% of the reported cases are of a low-grade type. A consensus recognizing conservative surgery as the most reasonable treatment for these lesions has almost been reached. However, fear of jeopardizing the patency of the laryngeal airway as a result of a wide cricoid excision and also the fear of repeated recurrences could still push some surgeons to perform a total laryngectomy in the case of laryngeal chondrosarcoma. After a brief review of the literature, we will present five cases of laryngeal chondrosarcoma that were treated and followed at the Clermont-Ferrand University Medical Center over the last two decades. These cases exhibit many of the clinicopathologic features of the tumor and illustrate the pitfalls of diagnosis and treatment. In light of this presentation, we will discuss the widely accepted management as well as a newly suggested treatment modality for this disease.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"European Archives of Oto-Rhino-Laryngology","grobid_abstract_attachment_id":47285979},"translated_abstract":null,"internal_url":"https://www.academia.edu/27022189/Laryngeal_chondrosarcoma_a_report_of_five_cases","translated_internal_url":"","created_at":"2016-07-15T22:51:10.400-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":51052825,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":22443044,"work_id":27022189,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010114,"email":"c***d@ec.europa.eu","display_order":0,"name":"Christophe Guichard","title":"Laryngeal chondrosarcoma: a report of five cases"},{"id":22443050,"work_id":27022189,"tagging_user_id":51052825,"tagged_user_id":null,"co_author_invite_id":5010118,"email":"l***n@u-clermont1.fr","display_order":4194304,"name":"L. 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