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In 1999, he graduated from Ege University Science Faculty Department of Biology. Between 1999 and 2002, he received his master's degree in Ege University Faculty of Medicine, Histology and Embryology Department, and his doctorate studies between 2002-2006. He received his title as Associate Professor in 2011 and Professor in 2017. Between 2014-2017, he served as the director of the Cell- Tissue Application and Research Center of the Ege University. He is interested in cord blood and tissue banking, regenerative medicine, developmental biology, nervous system histology and embryology. 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In 1999, he graduated from Ege University Science Faculty Department of Biology. Between 1999 and 2002, he received his master's degree in Ege University Faculty of Medicine, Histology and Embryology Department, and his doctorate studies between 2002-2006. He received his title as Associate Professor in 2011 and Professor in 2017. Between 2014-2017, he served as the director of the Cell- Tissue Application and Research Center of the Ege University. He is interested in cord blood and tissue banking, regenerative medicine, developmental biology, nervous system histology and embryology.  In addition to memberships to scientific institutions, he serves as a member and referee of national and international scientific journals.<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><h3 class="ds2-5-heading-sans-serif-xs">Related Authors</h3></div><ul class="suggested-user-card-list" data-nosnippet="true"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a data-nosnippet="" href="https://open.academia.edu/SamanthaMurphy"><img class="profile-avatar u-positionAbsolute" alt="Samantha Murphy related author profile picture" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/65663/18482/17184/s200_samantha.murphy.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://open.academia.edu/SamanthaMurphy">Samantha Murphy</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">The Open University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a data-nosnippet="" href="https://sakarya.academia.edu/HarunKIRILMAZ"><img class="profile-avatar u-positionAbsolute" alt="Harun KIRILMAZ related author profile picture" border="0" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://sakarya.academia.edu/HarunKIRILMAZ">Harun KIRILMAZ</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Sakarya University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a data-nosnippet="" href="https://bournemouth.academia.edu/LeeAnnFenge"><img class="profile-avatar u-positionAbsolute" alt="Lee-Ann Fenge related author profile picture" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/1237864/2873506/17009323/s200_lee-ann.fenge.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://bournemouth.academia.edu/LeeAnnFenge">Lee-Ann Fenge</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Bournemouth University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a data-nosnippet="" href="https://gazi.academia.edu/%C4%B0brahimHoca"><img class="profile-avatar u-positionAbsolute" alt="İbrahim Hoca related author profile picture" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/3080541/1012237/1265603/s200__brahim.hoca.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://gazi.academia.edu/%C4%B0brahimHoca">İbrahim Hoca</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Gazi University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a data-nosnippet="" href="https://comu.academia.edu/BernaBurcuYilmaz"><img class="profile-avatar u-positionAbsolute" alt="Assoc. 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href="https://brocku.academia.edu/DragosSimandan">Dragos Simandan</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Brock University</p></div></div></ul></div><style type="text/css">.suggested-academics--header h3{font-size:16px;font-weight:500;line-height:20px}</style><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="61194091" href="https://www.academia.edu/Documents/in/Economics_of_Health_and_Social_Care"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://ege.academia.edu/YigitUYANIKGIL","location":"/YigitUYANIKGIL","scheme":"https","host":"ege.academia.edu","port":null,"pathname":"/YigitUYANIKGIL","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" 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class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Yigit UYANIKGIL</h3></div><div class="js-work-strip profile--work_container" data-work-id="123614068"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123614068/Obituary_Professor_Dr_Meral_Baka_1955_2024_"><img alt="Research paper thumbnail of Obituary: Professor Dr. Meral Baka (1955–2024)" class="work-thumbnail" src="https://attachments.academia-assets.com/118005456/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123614068/Obituary_Professor_Dr_Meral_Baka_1955_2024_">Obituary: Professor Dr. Meral Baka (1955–2024)</a></div><div class="wp-workCard_item"><span>Child's nervous system</span><span>, Mar 13, 2024</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b677c5f28420f077ff877f81a88ce0dd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118005456,"asset_id":123614068,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118005456/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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Renowned for her unique teaching methods, including early use of concept mapping and hands-on experiments, she made significant contributions to neuroscience in Turkey. 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Chemical and thermal factors that occur in the peritoneal cavity and serosal surfaces, causing abdominal trauma, or infection and foreign body reactions may cause adhesion formation. Although the classification of intraabdominal adhesions is generally based on adhesion density and severity of prognosis, there is not yet a worldwide accepted standard classification system. Intraabdominal adhesions show clinical reflections with negative consequences such as pain, infertility, prolonged hospital stay after surgery and economic burden. In conclusion, adhesions encountered in the postoperative period are a serious problem and further studies should be adapted from laboratory environment to clinical research models in order to prevent adhesion formation. This review was prepared to review the literature on intraabdominal adhesion formation, histopathology, grading, prevention and clinical significance.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5379ad0701d6d388c9557fe79fe59832" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951712,"asset_id":120960186,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951712/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960186"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960186"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960186; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960186]").text(description); $(".js-view-count[data-work-id=120960186]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960186; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960186']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5379ad0701d6d388c9557fe79fe59832" } } $('.js-work-strip[data-work-id=120960186]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960186,"title":"İntrabdominal Adezyon Oluşum Mekanizmalarına ve Tedavi Stratejilerine Histopatolojik Bakış","translated_title":"","metadata":{"publisher":"Çukurova University Faculty of Medicine","grobid_abstract":"Intraabdominal adhesions are an important health problem that is seen in the postoperative period and negatively affects the quality of life. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960185-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960183"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960183/S%C4%B1%C3%A7an_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_g%C3%B6sterilmesi"><img alt="Research paper thumbnail of Sıçan midesinde leptin ekspresyonunun immunohistokimyasal olarak gösterilmesi" class="work-thumbnail" src="https://attachments.academia-assets.com/115951711/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960183/S%C4%B1%C3%A7an_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_g%C3%B6sterilmesi">Sıçan midesinde leptin ekspresyonunun immunohistokimyasal olarak gösterilmesi</a></div><div class="wp-workCard_item"><span>Ege Tıp Dergisi</span><span>, Mar 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. Đlk olarak yağ dokus...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. Đlk olarak yağ dokusunda tanımlanan leptinin son zamanlarda vücutta çeşitli dokularda da ifade edildiği gözlenmiştir. Çeşitli çalışmalar leptinin midede de fonksiyon gösterebileceğini önermektedir. Bu çalışmada, sıçan mide dokusunda leptinin immünohistokimyasal dağılımını ve ifadesini araştırmak amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada 190-210 gr ağırlığında erkek sıçanlar kullanılmıştır. Işık mikroskopik incelemeler için Wistar albino 5 sıçan anastezi edilmiş ve heparinize edilip fosfat tamponlu % 4 paraformaldehit ile intrakardiyak perfüze edilmiştir. Rutin histolojik takip uygulanan mide dokusu daha sonra 5 µm kalınlıkta kesilip Leptin immunohistokimyasal boyaması yapılmıştır. Bulgular: Midenin fundus bölgesinde leptin (+) boyanan gerek esas hücre, gerekse pariyetal hücre sayısı korpus bölgesine oranla anlamlı derecede artmış bulundu. Korpustaki leptin (+) hücreler kıyaslandığında esas hücre ve pariyetal hücre sayıları arasında anlamlı bir fark saptanmadı; diğer taraftan fundustaki leptin (+) esas hücre sayısının leptin (+) pariyetal hücre sayısından anlamlı şekilde fazla olduğu gözlendi. Ayrıca, myenterik pleksusta boyanma gözlemlendi. Sonuç:Bu çalışmada diğer çalışmalardan farklı olarak temel olarak gastrointestinal hareketleri kontrol eden myenterik pleksusda da leptinin varlığı gösterilmektedir. Leptinin sinerjistik etki gösterip beslenmenin düzenlenmesinde kısa süreli regülasyon ve/veya uzun süreli regülasyonda rol oynayabileceği gösterilmektedir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7432f4df4c3032b8fa6ea1854cf92f2b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951711,"asset_id":120960183,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951711/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960183"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960183"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960183; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960183]").text(description); $(".js-view-count[data-work-id=120960183]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960183; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960183']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7432f4df4c3032b8fa6ea1854cf92f2b" } } $('.js-work-strip[data-work-id=120960183]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960183,"title":"Sıçan midesinde leptin ekspresyonunun immunohistokimyasal olarak gösterilmesi","translated_title":"","metadata":{"grobid_abstract":"Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. 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Korpustaki leptin (+) hücreler kıyaslandığında esas hücre ve pariyetal hücre sayıları arasında anlamlı bir fark saptanmadı; diğer taraftan fundustaki leptin (+) esas hücre sayısının leptin (+) pariyetal hücre sayısından anlamlı şekilde fazla olduğu gözlendi. Ayrıca, myenterik pleksusta boyanma gözlemlendi. Sonuç:Bu çalışmada diğer çalışmalardan farklı olarak temel olarak gastrointestinal hareketleri kontrol eden myenterik pleksusda da leptinin varlığı gösterilmektedir. Leptinin sinerjistik etki gösterip beslenmenin düzenlenmesinde kısa süreli regülasyon ve/veya uzun süreli regülasyonda rol oynayabileceği gösterilmektedir.","publication_date":{"day":1,"month":3,"year":2009,"errors":{}},"publication_name":"Ege Tıp Dergisi","grobid_abstract_attachment_id":115951711},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960183/S%C4%B1%C3%A7an_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_g%C3%B6sterilmesi","translated_internal_url":"","created_at":"2024-06-13T04:02:28.341-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951711,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951711/thumbnails/1.jpg","file_name":"350362.pdf","download_url":"https://www.academia.edu/attachments/115951711/download_file","bulk_download_file_name":"Sican_midesinde_leptin_ekspresyonunun_im.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951711/350362-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DSican_midesinde_leptin_ekspresyonunun_im.pdf\u0026Expires=1743662386\u0026Signature=GwWBwp6HBjw6WYYf12J3nOL6HY-Q8w~qxKJbslj998GxfhXZLu69K8iI2o4f7bQsjdCb5VzdHlE9J7MThAe6tE1m7yR5E4PxXTsCfK3fBd4P5OgqyhVbJOmTV8UQwlFhOcyAFsa7P5sdkJwARi14xTh6giMobF~zkkAOzbVawkM-kevSCsdv9MhFtaFA5jlIoF~RDdYJMxpXqI1P-CvDv3FlrS0GlJLeyw0rGJnQxXsvWwx-bu~3hIvlgSmER7l8jas4uylBATLP5nXRhK4D-9H7cer0Drs6KeDd0PrW8WZrQZLbwaeuLaET-iIoSOvd2z~Bgwy2CUJ1lG~3vp6N-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sıçan_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_gösterilmesi","translated_slug":"","page_count":6,"language":"tr","content_type":"Work","summary":"Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. 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Korpustaki leptin (+) hücreler kıyaslandığında esas hücre ve pariyetal hücre sayıları arasında anlamlı bir fark saptanmadı; diğer taraftan fundustaki leptin (+) esas hücre sayısının leptin (+) pariyetal hücre sayısından anlamlı şekilde fazla olduğu gözlendi. Ayrıca, myenterik pleksusta boyanma gözlemlendi. Sonuç:Bu çalışmada diğer çalışmalardan farklı olarak temel olarak gastrointestinal hareketleri kontrol eden myenterik pleksusda da leptinin varlığı gösterilmektedir. Leptinin sinerjistik etki gösterip beslenmenin düzenlenmesinde kısa süreli regülasyon ve/veya uzun süreli regülasyonda rol oynayabileceği gösterilmektedir.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951711,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951711/thumbnails/1.jpg","file_name":"350362.pdf","download_url":"https://www.academia.edu/attachments/115951711/download_file","bulk_download_file_name":"Sican_midesinde_leptin_ekspresyonunun_im.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951711/350362-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DSican_midesinde_leptin_ekspresyonunun_im.pdf\u0026Expires=1743662386\u0026Signature=GwWBwp6HBjw6WYYf12J3nOL6HY-Q8w~qxKJbslj998GxfhXZLu69K8iI2o4f7bQsjdCb5VzdHlE9J7MThAe6tE1m7yR5E4PxXTsCfK3fBd4P5OgqyhVbJOmTV8UQwlFhOcyAFsa7P5sdkJwARi14xTh6giMobF~zkkAOzbVawkM-kevSCsdv9MhFtaFA5jlIoF~RDdYJMxpXqI1P-CvDv3FlrS0GlJLeyw0rGJnQxXsvWwx-bu~3hIvlgSmER7l8jas4uylBATLP5nXRhK4D-9H7cer0Drs6KeDd0PrW8WZrQZLbwaeuLaET-iIoSOvd2z~Bgwy2CUJ1lG~3vp6N-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951710/thumbnails/1.jpg","file_name":"350362.pdf","download_url":"https://www.academia.edu/attachments/115951710/download_file","bulk_download_file_name":"Sican_midesinde_leptin_ekspresyonunun_im.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951710/350362-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DSican_midesinde_leptin_ekspresyonunun_im.pdf\u0026Expires=1743662386\u0026Signature=AljYeiXvpBYxWkj3AWtf8eXI7pNpSvXJkK1rGrdDSS5sB3EMAJObfqoKp9AcPf3XsXZ4eVmWyHrUvb~rP0Uc0GO4vakKsjAA9b~6jeWw2qR47DvAiI1Efjl~lwf4fZr94eZQmxHWJcgENEyJni3r~4zgBYMnPHoh0UHrqHNlToIkbbdT6MES5wy~iicS2aTpbUZoqyAxJc~7ZDwUrubI6A7xfytJq1GJRZE8sL6TL3gTnMEhc8warrzT~JpofcISIEFtPkW9w0xMc2fRuyX1dogURSdUbsPSkzkIdRtmfPPASXK9QYQYd44qPSLCspY7ORD1SHpoxy~lJoeeqlrviw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":135357,"name":"Leptin","url":"https://www.academia.edu/Documents/in/Leptin"}],"urls":[{"id":42903039,"url":"https://egetipdergisi.com.tr/tr/download/article-file/350362"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960183-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960182"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960182/Investigation_of_the_combination_of_anti_PD_L1_mAb_with_HER2_neu_loaded_dendritic_cells_and_QS_21_saponin_adjuvant_effect_against_HER2_positive_breast_cancer_in_mice"><img alt="Research paper thumbnail of Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/115951748/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960182/Investigation_of_the_combination_of_anti_PD_L1_mAb_with_HER2_neu_loaded_dendritic_cells_and_QS_21_saponin_adjuvant_effect_against_HER2_positive_breast_cancer_in_mice">Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice</a></div><div class="wp-workCard_item"><span>Immunopharmacology and Immunotoxicology</span><span>, Jun 9, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cance...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cancers including 25% of breast cancers. Since combination therapy consisting of multiple therapeutic approaches is considered a promising regimen, we examined combination treatment modalities in a xenograft model in Balb/c mice injected with 4T1-HER2 cells. We used HER2/neu-loaded bone marrow-derived dendritic cells (BM-DC's) along with anti-PD-L1 monoclonal antibody in a new combination immunotherapy model. Methods: The combination was composed of an active immunotherapy (i.e. BM-DC-based vaccine) designed to boost the immune response against target antigen and was augmented by using anti-PD-L1 mAb to prevent immune evasion by the xenografted tumors. The vaccine combination was further supported using a QS-21 saponin adjuvant and the immune response was evaluated. Results: Mice treated with HER2/neu-loaded BM-DCs, combined with QS-21 and anti-PD-L1 mAb had significantly decreased tumor sizes and their splenocytes had enhanced cytotoxic activity, based on the lactate dehydrogenase (LDH) assay, compared to vaccine and adjuvant groups alone. The same vaccination group demonstrated a remarkable increase in IFN-c secreting CD8þ T-cells analyzed by flow cytometry. ELISA data also revealed a significant increase in the serum anti-HER2 IgG1 response; in addition, there was significant splenocyte proliferation upon stimulation with antigen compared to vaccine and adjuvant groups. Consistently, a significant infiltration of CD4þ, CD8þ immune cells in and around the tumors was observed. Conclusions: Our data suggest that the BM-DC þ HER2/neu þ QS-21 þ anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="994b687f91f4f66bcc9f5883ffe1f864" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951748,"asset_id":120960182,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951748/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960182"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960182"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960182; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960182]").text(description); $(".js-view-count[data-work-id=120960182]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960182; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960182']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "994b687f91f4f66bcc9f5883ffe1f864" } } $('.js-work-strip[data-work-id=120960182]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960182,"title":"Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice","translated_title":"","metadata":{"publisher":"Informa","grobid_abstract":"Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cancers including 25% of breast cancers. Since combination therapy consisting of multiple therapeutic approaches is considered a promising regimen, we examined combination treatment modalities in a xenograft model in Balb/c mice injected with 4T1-HER2 cells. We used HER2/neu-loaded bone marrow-derived dendritic cells (BM-DC's) along with anti-PD-L1 monoclonal antibody in a new combination immunotherapy model. Methods: The combination was composed of an active immunotherapy (i.e. BM-DC-based vaccine) designed to boost the immune response against target antigen and was augmented by using anti-PD-L1 mAb to prevent immune evasion by the xenografted tumors. The vaccine combination was further supported using a QS-21 saponin adjuvant and the immune response was evaluated. Results: Mice treated with HER2/neu-loaded BM-DCs, combined with QS-21 and anti-PD-L1 mAb had significantly decreased tumor sizes and their splenocytes had enhanced cytotoxic activity, based on the lactate dehydrogenase (LDH) assay, compared to vaccine and adjuvant groups alone. The same vaccination group demonstrated a remarkable increase in IFN-c secreting CD8þ T-cells analyzed by flow cytometry. ELISA data also revealed a significant increase in the serum anti-HER2 IgG1 response; in addition, there was significant splenocyte proliferation upon stimulation with antigen compared to vaccine and adjuvant groups. Consistently, a significant infiltration of CD4þ, CD8þ immune cells in and around the tumors was observed. 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Since combination therapy consisting of multiple therapeutic approaches is considered a promising regimen, we examined combination treatment modalities in a xenograft model in Balb/c mice injected with 4T1-HER2 cells. We used HER2/neu-loaded bone marrow-derived dendritic cells (BM-DC's) along with anti-PD-L1 monoclonal antibody in a new combination immunotherapy model. Methods: The combination was composed of an active immunotherapy (i.e. BM-DC-based vaccine) designed to boost the immune response against target antigen and was augmented by using anti-PD-L1 mAb to prevent immune evasion by the xenografted tumors. The vaccine combination was further supported using a QS-21 saponin adjuvant and the immune response was evaluated. Results: Mice treated with HER2/neu-loaded BM-DCs, combined with QS-21 and anti-PD-L1 mAb had significantly decreased tumor sizes and their splenocytes had enhanced cytotoxic activity, based on the lactate dehydrogenase (LDH) assay, compared to vaccine and adjuvant groups alone. The same vaccination group demonstrated a remarkable increase in IFN-c secreting CD8þ T-cells analyzed by flow cytometry. ELISA data also revealed a significant increase in the serum anti-HER2 IgG1 response; in addition, there was significant splenocyte proliferation upon stimulation with antigen compared to vaccine and adjuvant groups. Consistently, a significant infiltration of CD4þ, CD8þ immune cells in and around the tumors was observed. Conclusions: Our data suggest that the BM-DC þ HER2/neu þ QS-21 þ anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951748,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951748/thumbnails/1.jpg","file_name":"08923973.2020.177564420240613-1-afz69k.pdf","download_url":"https://www.academia.edu/attachments/115951748/download_file","bulk_download_file_name":"Investigation_of_the_combination_of_anti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951748/08923973.2020.177564420240613-1-afz69k-libre.pdf?1718278704=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_the_combination_of_anti.pdf\u0026Expires=1743662386\u0026Signature=TShoF1j0Wcm0BwvXpiSAW~OBHFyyNQTKbVYsrnmHzE44NGxF0mliP19P3fXjNUU0XzKQaxgTpUQF1A3~Q7UL2l4iJyPhfpbH2mEsqMqM-I3P01NR84-PVFiBPC2XktcnAIBoZKK0~0fQ1T5vpN0bix0zITu9rwtgzlMxvsW~DxQt6MNBQgzz2KIueNGcQvRVWvbUdvpUXaljy90TqszejF3aIMEu7vekKzQcvjprbMaJGJL~UaNCjpQi1FmZyObIawmevp777F62grUv43rn-gKkMQAnzhTz0MdKwicqX2s92KqLOSZgM-UF80zvU257M-s8EgeFRenz7Ll9Eq2q3w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":216943,"name":"CD","url":"https://www.academia.edu/Documents/in/CD"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":809620,"name":"Saponin","url":"https://www.academia.edu/Documents/in/Saponin"},{"id":1485245,"name":"Adjuvant","url":"https://www.academia.edu/Documents/in/Adjuvant"}],"urls":[{"id":42903038,"url":"https://doi.org/10.1080/08923973.2020.1775644"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960182-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960181"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960181/Cellular_Signaling_Pathways_and_Their_Clinical_Reflections"><img alt="Research paper thumbnail of Cellular Signaling Pathways and Their Clinical Reflections" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Cellular Signaling Pathways and Their Clinical Reflections</div><div class="wp-workCard_item"><span>DOAJ (DOAJ: Directory of Open Access Journals)</span><span>, Jun 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cellular signaling pathways have important roles in cellular growth, differentiation, inflammator...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cellular signaling pathways have important roles in cellular growth, differentiation, inflammatory response and apoptosis and in regulation of cellular responses under various chemical stimulators. Different proteins which belong to these pathways may be exposed to loss-of-function or gain-of-function mutations; this may lead to many clinical phenotypes including primarily cancer. In this review information about basic working principles of these pathways and diseases related to them are included.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960181"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960181"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960181; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960181]").text(description); $(".js-view-count[data-work-id=120960181]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960181; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960181']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960181]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960181,"title":"Cellular Signaling Pathways and Their Clinical Reflections","translated_title":"","metadata":{"abstract":"Cellular signaling pathways have important roles in cellular growth, differentiation, inflammatory response and apoptosis and in regulation of cellular responses under various chemical stimulators. Different proteins which belong to these pathways may be exposed to loss-of-function or gain-of-function mutations; this may lead to many clinical phenotypes including primarily cancer. In this review information about basic working principles of these pathways and diseases related to them are included.","publisher":"DOAJ: Directory of Open Access Journals","publication_date":{"day":1,"month":6,"year":2010,"errors":{}},"publication_name":"DOAJ (DOAJ: Directory of Open Access Journals)"},"translated_abstract":"Cellular signaling pathways have important roles in cellular growth, differentiation, inflammatory response and apoptosis and in regulation of cellular responses under various chemical stimulators. Different proteins which belong to these pathways may be exposed to loss-of-function or gain-of-function mutations; this may lead to many clinical phenotypes including primarily cancer. 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Different proteins which belong to these pathways may be exposed to loss-of-function or gain-of-function mutations; this may lead to many clinical phenotypes including primarily cancer. In this review information about basic working principles of these pathways and diseases related to them are included.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":13827,"name":"Cell Biology","url":"https://www.academia.edu/Documents/in/Cell_Biology"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":2178767,"name":"Medical Archives","url":"https://www.academia.edu/Documents/in/Medical_Archives"}],"urls":[{"id":42903037,"url":"https://doaj.org/article/607c8b38ca344d899015763ad609cdbe"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960181-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960180"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960180/Di%C5%9F_Hekimli%C4%9Fi_i%C3%A7in_Anatominin_Temelleri"><img alt="Research paper thumbnail of Diş Hekimliği için Anatominin Temelleri" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Diş Hekimliği için Anatominin Temelleri</div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960180"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960180"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960180; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960180-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960179"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960179/Glukagon_benzeri_peptit_1in_ya%C4%9F_doku_kaynakl%C4%B1_mezenkimal_k%C3%B6k_h%C3%BCcrelerinin_kardiyomiyositlere_d%C3%B6n%C3%BC%C5%9Fmesi_%C3%BCzerindeki_etkisi"><img alt="Research paper thumbnail of Glukagon benzeri peptit-1'in yağ doku kaynaklı mezenkimal kök hücrelerinin kardiyomiyositlere dönüşmesi üzerindeki etkisi" class="work-thumbnail" src="https://attachments.academia-assets.com/115951707/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960179/Glukagon_benzeri_peptit_1in_ya%C4%9F_doku_kaynakl%C4%B1_mezenkimal_k%C3%B6k_h%C3%BCcrelerinin_kardiyomiyositlere_d%C3%B6n%C3%BC%C5%9Fmesi_%C3%BCzerindeki_etkisi">Glukagon benzeri peptit-1'in yağ doku kaynaklı mezenkimal kök hücrelerinin kardiyomiyositlere dönüşmesi üzerindeki etkisi</a></div><div class="wp-workCard_item"><span>Ege Tıp Dergisi</span><span>, Dec 12, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: Mesenchymal stem cells can easily differentiate into cardiomyocytes in vitro conditions usin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: Mesenchymal stem cells can easily differentiate into cardiomyocytes in vitro conditions using various protocols. However, the agents used in these protocols have been reported to have some adverse effects on cell viability. Azacitidine is used to differentiate mesenchymal stem cells into cardiac muscle cells. The aim of the present study was to investigate the effects of Exenatide a GLP-1 receptor agonist, on differentiation and viability of human adipose tissue derived stem cells into cardiomyocytes. Materials and Methods: The effects of Azacytidine and Exenatide on cell viability and proliferation of human adipose tissue derived stem cells were analyzed with cytotoxicity assay. For differentiation procedure, of human adipose tissue derived stem cells were incubated with Azacytidine and Exenatide through four weeks. The morphological alterations of human adipose tissue derived stem cells were monitored and the expressions of cardiomyogenic differentiation markers (cTnI, GATA4 ve MYH7) were evaluated immunohistochemically. Also, cardiac troponin I (cTnI) levels in the cultures were measured using enzyme-linked immunosorbent assay. Results were evaluated by one way analysis of variance (ANOVA) and post-hoc test. Results: Treatment of the human adipose tissue derived stem cells with Azacytidine significantly decreased cell viability (54.4%) compared to control whereas treatment of cells with Azacytidine + Exenatide prevented cell death in a dose-dependent manner. Cells treated with Azacytidine and Exenatide showed significant morphological alterations consistent with cardiyomyogenic differentiation, and increase in expression cardiomyogenic markers. cTnI levels were found significantly higher in cultures treated separately and together with Azacytidine and Exenatide compared to control. Conclusion: Overall, these findings suggested that GLP-1 receptor agonist Exenatide may have beneficial effects on cardiomyogenic differention of human adipose tissue derived stem cells by reducing cell damage caused by Azacytidine.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="452353df55e61c1741db8c8bd325ad3e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951707,"asset_id":120960179,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951707/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960179"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960179"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960179; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960179]").text(description); $(".js-view-count[data-work-id=120960179]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960179; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960179']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "452353df55e61c1741db8c8bd325ad3e" } } $('.js-work-strip[data-work-id=120960179]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960179,"title":"Glukagon benzeri peptit-1'in yağ doku kaynaklı mezenkimal kök hücrelerinin kardiyomiyositlere dönüşmesi üzerindeki etkisi","translated_title":"","metadata":{"grobid_abstract":"Aim: Mesenchymal stem cells can easily differentiate into cardiomyocytes in vitro conditions using various protocols. However, the agents used in these protocols have been reported to have some adverse effects on cell viability. Azacitidine is used to differentiate mesenchymal stem cells into cardiac muscle cells. The aim of the present study was to investigate the effects of Exenatide a GLP-1 receptor agonist, on differentiation and viability of human adipose tissue derived stem cells into cardiomyocytes. Materials and Methods: The effects of Azacytidine and Exenatide on cell viability and proliferation of human adipose tissue derived stem cells were analyzed with cytotoxicity assay. For differentiation procedure, of human adipose tissue derived stem cells were incubated with Azacytidine and Exenatide through four weeks. The morphological alterations of human adipose tissue derived stem cells were monitored and the expressions of cardiomyogenic differentiation markers (cTnI, GATA4 ve MYH7) were evaluated immunohistochemically. Also, cardiac troponin I (cTnI) levels in the cultures were measured using enzyme-linked immunosorbent assay. Results were evaluated by one way analysis of variance (ANOVA) and post-hoc test. Results: Treatment of the human adipose tissue derived stem cells with Azacytidine significantly decreased cell viability (54.4%) compared to control whereas treatment of cells with Azacytidine + Exenatide prevented cell death in a dose-dependent manner. Cells treated with Azacytidine and Exenatide showed significant morphological alterations consistent with cardiyomyogenic differentiation, and increase in expression cardiomyogenic markers. cTnI levels were found significantly higher in cultures treated separately and together with Azacytidine and Exenatide compared to control. Conclusion: Overall, these findings suggested that GLP-1 receptor agonist Exenatide may have beneficial effects on cardiomyogenic differention of human adipose tissue derived stem cells by reducing cell damage caused by Azacytidine.","publication_date":{"day":12,"month":12,"year":2022,"errors":{}},"publication_name":"Ege Tıp Dergisi","grobid_abstract_attachment_id":115951707},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960179/Glukagon_benzeri_peptit_1in_ya%C4%9F_doku_kaynakl%C4%B1_mezenkimal_k%C3%B6k_h%C3%BCcrelerinin_kardiyomiyositlere_d%C3%B6n%C3%BC%C5%9Fmesi_%C3%BCzerindeki_etkisi","translated_internal_url":"","created_at":"2024-06-13T04:02:25.797-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951707,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951707/thumbnails/1.jpg","file_name":"2673316.pdf","download_url":"https://www.academia.edu/attachments/115951707/download_file","bulk_download_file_name":"Glukagon_benzeri_peptit_1in_yag_doku_kay.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951707/2673316-libre.pdf?1718278712=\u0026response-content-disposition=attachment%3B+filename%3DGlukagon_benzeri_peptit_1in_yag_doku_kay.pdf\u0026Expires=1743662386\u0026Signature=bsD0Y8qWMJDkYOCk5TLEc7nFSJKpk3G-OLvP9RQmqwcbMIII-jA4q~uS202z8lYZgxJHsc0DEpwK9lY72fnoEfn4XQeMsMCVJ3LyB-po9f5eZuv-KcUfEW~a~LiTVKROgVx5zzOIZ4P~5ks5xgwBUm4-xVGOVgwFewx3SJgiI8a38iUlPT85ImUnO9Dfk5TZn7Q6sDXVfxJ8A9heNwICN2R76Uh~Oyi~~1F0-Yq5OZeIHHksNferm2mtqLd8MSkKqB9mbTtJedxfX~a3f8xvAD36E34TJcYxDzE7vfHKtQQ3Y6o9IMwDmnEOZbEgovgjJFseQqZDjGDnVodVljZStg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Glukagon_benzeri_peptit_1in_yağ_doku_kaynaklı_mezenkimal_kök_hücrelerinin_kardiyomiyositlere_dönüşmesi_üzerindeki_etkisi","translated_slug":"","page_count":11,"language":"en","content_type":"Work","summary":"Aim: Mesenchymal stem cells can easily differentiate into cardiomyocytes in vitro conditions using various protocols. However, the agents used in these protocols have been reported to have some adverse effects on cell viability. Azacitidine is used to differentiate mesenchymal stem cells into cardiac muscle cells. The aim of the present study was to investigate the effects of Exenatide a GLP-1 receptor agonist, on differentiation and viability of human adipose tissue derived stem cells into cardiomyocytes. Materials and Methods: The effects of Azacytidine and Exenatide on cell viability and proliferation of human adipose tissue derived stem cells were analyzed with cytotoxicity assay. For differentiation procedure, of human adipose tissue derived stem cells were incubated with Azacytidine and Exenatide through four weeks. The morphological alterations of human adipose tissue derived stem cells were monitored and the expressions of cardiomyogenic differentiation markers (cTnI, GATA4 ve MYH7) were evaluated immunohistochemically. Also, cardiac troponin I (cTnI) levels in the cultures were measured using enzyme-linked immunosorbent assay. Results were evaluated by one way analysis of variance (ANOVA) and post-hoc test. Results: Treatment of the human adipose tissue derived stem cells with Azacytidine significantly decreased cell viability (54.4%) compared to control whereas treatment of cells with Azacytidine + Exenatide prevented cell death in a dose-dependent manner. Cells treated with Azacytidine and Exenatide showed significant morphological alterations consistent with cardiyomyogenic differentiation, and increase in expression cardiomyogenic markers. cTnI levels were found significantly higher in cultures treated separately and together with Azacytidine and Exenatide compared to control. Conclusion: Overall, these findings suggested that GLP-1 receptor agonist Exenatide may have beneficial effects on cardiomyogenic differention of human adipose tissue derived stem cells by reducing cell damage caused by Azacytidine.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951707,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951707/thumbnails/1.jpg","file_name":"2673316.pdf","download_url":"https://www.academia.edu/attachments/115951707/download_file","bulk_download_file_name":"Glukagon_benzeri_peptit_1in_yag_doku_kay.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951707/2673316-libre.pdf?1718278712=\u0026response-content-disposition=attachment%3B+filename%3DGlukagon_benzeri_peptit_1in_yag_doku_kay.pdf\u0026Expires=1743662386\u0026Signature=bsD0Y8qWMJDkYOCk5TLEc7nFSJKpk3G-OLvP9RQmqwcbMIII-jA4q~uS202z8lYZgxJHsc0DEpwK9lY72fnoEfn4XQeMsMCVJ3LyB-po9f5eZuv-KcUfEW~a~LiTVKROgVx5zzOIZ4P~5ks5xgwBUm4-xVGOVgwFewx3SJgiI8a38iUlPT85ImUnO9Dfk5TZn7Q6sDXVfxJ8A9heNwICN2R76Uh~Oyi~~1F0-Yq5OZeIHHksNferm2mtqLd8MSkKqB9mbTtJedxfX~a3f8xvAD36E34TJcYxDzE7vfHKtQQ3Y6o9IMwDmnEOZbEgovgjJFseQqZDjGDnVodVljZStg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951708,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951708/thumbnails/1.jpg","file_name":"2673316.pdf","download_url":"https://www.academia.edu/attachments/115951708/download_file","bulk_download_file_name":"Glukagon_benzeri_peptit_1in_yag_doku_kay.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951708/2673316-libre.pdf?1718278702=\u0026response-content-disposition=attachment%3B+filename%3DGlukagon_benzeri_peptit_1in_yag_doku_kay.pdf\u0026Expires=1743662386\u0026Signature=Th38zIiixxU29SF28S2rIWIWQXqg960W9N3GA2OWZIyAwieZfvF50F~8F6PVV8ic0NseKWrHZbAyxeHvBUZv~B72Mmyskqyb9mT1BFJadaiqPMvufiTegsR3LunY17GxAyk4cFknUSdyWb5NUOJvqXU16sfnBf4dBP6VugsWMTNWSHWOGedxmo~XAYxKks1SaudRMEwexqZpnI-frnlj-QuK7QclFEas1yV3jAmyM7vUB5zwowQbuN6fQm3NQX2qBhE1PRO0MscAXeb7-2WP~AStfT9ZRvnnkWdjELMDue1sur~EiFD0-Lh-gPGkMrlcN0IHyVdhwgNJYLt2mPkrwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":162972,"name":"Mesenchymal Stem Cell","url":"https://www.academia.edu/Documents/in/Mesenchymal_Stem_Cell"},{"id":216943,"name":"CD","url":"https://www.academia.edu/Documents/in/CD"},{"id":1335152,"name":"Viability assay","url":"https://www.academia.edu/Documents/in/Viability_assay"}],"urls":[{"id":42903035,"url":"http://egetipdergisi.com.tr/en/download/article-file/2673316"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960179-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960178"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960178/Adipose_Tissue_Mesenchymal_Stem_Cells_Exposed_To_Oxytocin_and_Sunitinib_are_Synergistically_Dystrophic"><img alt="Research paper thumbnail of Adipose Tissue Mesenchymal Stem Cells Exposed To Oxytocin and Sunitinib are Synergistically Dystrophic" class="work-thumbnail" src="https://attachments.academia-assets.com/115951704/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960178/Adipose_Tissue_Mesenchymal_Stem_Cells_Exposed_To_Oxytocin_and_Sunitinib_are_Synergistically_Dystrophic">Adipose Tissue Mesenchymal Stem Cells Exposed To Oxytocin and Sunitinib are Synergistically Dystrophic</a></div><div class="wp-workCard_item"><span>Dicle Medical Journal</span><span>, Sep 2, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after or...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after organ and tissue transplantation, in addition to their current wide range of uses and research areas. Sunitinib is a receptor tyrosine kinase with immunosuppressive properties and its cytotoxic activity in different types of cells is known. Our study aimed to elucidate the effect of oxytocin on sunitinib-treated MSCs. Methods: For this purpose, commercially available rat adipose tissue-derived MSC (ADMSCs) was used. The individual or combinational effect of the active substances on viability was evaluated with WST-1, the effect on apoptosis Annexin V, the effect on oxidative stress markers MDA, CAT, GPX, and SOD ELISA tests. Results: The IC50 value of sunitinib was determined as 44.57 µM at the 48th hour, and it was determined that oxytocin had no cytotoxic effect in doses up to 100 µM. Treatment of the two agents in combination increased the cytotoxic effect of sunitinib. Oxytocin attenuated the effect of sunitinib on apoptosis and lipid peroxidation. Conclusion: It is important to investigate the efficacy of these two substances individually and in combination with ADMSCs with further experiments to evaluate the potential use of oxytocin in organ and tissue transplantations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="67211c48673b667592660437db5c9a84" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951704,"asset_id":120960178,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951704/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960178"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960178"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960178; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960178]").text(description); $(".js-view-count[data-work-id=120960178]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960178; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960178']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "67211c48673b667592660437db5c9a84" } } $('.js-work-strip[data-work-id=120960178]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960178,"title":"Adipose Tissue Mesenchymal Stem Cells Exposed To Oxytocin and Sunitinib are Synergistically Dystrophic","translated_title":"","metadata":{"publisher":"Dicle University Medical School","ai_title_tag":"Oxytocin and Sunitinib Affect Stem Cell Viability","grobid_abstract":"Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after organ and tissue transplantation, in addition to their current wide range of uses and research areas. Sunitinib is a receptor tyrosine kinase with immunosuppressive properties and its cytotoxic activity in different types of cells is known. Our study aimed to elucidate the effect of oxytocin on sunitinib-treated MSCs. Methods: For this purpose, commercially available rat adipose tissue-derived MSC (ADMSCs) was used. The individual or combinational effect of the active substances on viability was evaluated with WST-1, the effect on apoptosis Annexin V, the effect on oxidative stress markers MDA, CAT, GPX, and SOD ELISA tests. Results: The IC50 value of sunitinib was determined as 44.57 µM at the 48th hour, and it was determined that oxytocin had no cytotoxic effect in doses up to 100 µM. Treatment of the two agents in combination increased the cytotoxic effect of sunitinib. Oxytocin attenuated the effect of sunitinib on apoptosis and lipid peroxidation. 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Sunitinib is a receptor tyrosine kinase with immunosuppressive properties and its cytotoxic activity in different types of cells is known. Our study aimed to elucidate the effect of oxytocin on sunitinib-treated MSCs. Methods: For this purpose, commercially available rat adipose tissue-derived MSC (ADMSCs) was used. The individual or combinational effect of the active substances on viability was evaluated with WST-1, the effect on apoptosis Annexin V, the effect on oxidative stress markers MDA, CAT, GPX, and SOD ELISA tests. Results: The IC50 value of sunitinib was determined as 44.57 µM at the 48th hour, and it was determined that oxytocin had no cytotoxic effect in doses up to 100 µM. Treatment of the two agents in combination increased the cytotoxic effect of sunitinib. Oxytocin attenuated the effect of sunitinib on apoptosis and lipid peroxidation. Conclusion: It is important to investigate the efficacy of these two substances individually and in combination with ADMSCs with further experiments to evaluate the potential use of oxytocin in organ and tissue transplantations.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951704,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951704/thumbnails/1.jpg","file_name":"2628657.pdf","download_url":"https://www.academia.edu/attachments/115951704/download_file","bulk_download_file_name":"Adipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951704/2628657-libre.pdf?1718278715=\u0026response-content-disposition=attachment%3B+filename%3DAdipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf\u0026Expires=1743662386\u0026Signature=bzglZ~9MFGEue2FtMj0bsuy8nnQrMgND6PE-GPSvnSgPpeJZU~cVo343CdyE8JLkQ5Ip7RsPWHAmdvRfexPZ9kfGfZxz1dDn~G1~NLCUmcO5nzpb24SIeqdVdrVsLq2KpafTAU8eHaOon7-VlKEq2eiUfvgfFZcki6B5iEHfzijjIzl2W36JmIdpmim5VRuKTySCG6RGwySQ5b2zaMjV8~l6URJhT1QFJxUgfRarD1ynNdTjqi~G890DHf~ufWUP7~mx4hbAoIBk60p1WvF1QRzt~wCZXKh4w4EEMYGLHHt3MwhNKUIF32~hAH8Bf6~LqYOcZ8ga21mnBOu-yM5PuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951705,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951705/thumbnails/1.jpg","file_name":"2628657.pdf","download_url":"https://www.academia.edu/attachments/115951705/download_file","bulk_download_file_name":"Adipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951705/2628657-libre.pdf?1718278713=\u0026response-content-disposition=attachment%3B+filename%3DAdipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf\u0026Expires=1743662386\u0026Signature=SovaLZLqM-A9F~OaJg9SWwvZNhYOqvYvuIFvLpQywcJNDSPHFTDtdCh-Idna7hwM2c-wOgWWvmLTjLB504MuMYcpB~ni-lqUy6ogEbSJmKCLsOHqLVRQLdzvty~twimCPkTRKdP2G1Dt-NiFowt2UxjuAdkaB13BR2THJQVywVm6jPbTRX5wotbUijSFTEIFpC9gM4HSbWfpHbcpqtPavm24uasVPIU9wLR37D0-mqWXygvr0IDEgLgUqu8chwjuJXTRLRn2lf3YzKKu7JU6hqfHoeQpRqS14UVnBTl6~kZ6em3VcyQCDyQ0zizeFlqOmtLQNrqHu1cF0K1DWYXuJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":162972,"name":"Mesenchymal Stem Cell","url":"https://www.academia.edu/Documents/in/Mesenchymal_Stem_Cell"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation"},{"id":1213146,"name":"Sunitinib","url":"https://www.academia.edu/Documents/in/Sunitinib"}],"urls":[{"id":42903034,"url":"https://dergipark.org.tr/en/download/article-file/2628657"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960178-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960177"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960177/Rejeneratif_t%C4%B1pta_model_organizma_Aksolotl_Ambystoma_Mexicanum_"><img alt="Research paper thumbnail of Rejeneratif tıpta model organizma; Aksolotl (Ambystoma Mexicanum)" class="work-thumbnail" src="https://attachments.academia-assets.com/115951703/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960177/Rejeneratif_t%C4%B1pta_model_organizma_Aksolotl_Ambystoma_Mexicanum_">Rejeneratif tıpta model organizma; Aksolotl (Ambystoma Mexicanum)</a></div><div class="wp-workCard_item"><span>Ege Tıp Dergisi</span><span>, Mar 15, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The axolotl has an extraordinary capacity to regenerate damaged and lost structures, especially t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The axolotl has an extraordinary capacity to regenerate damaged and lost structures, especially the nervous system, limbs, organs such as the eye and heart, without causing scarring. It has become a very important model organism by attracting the attention of scientists working in both developmental biology and regenerative medicine and stem cell biology. The axolotl, which is amphibian and tetrapod, is a more preferred model due to its ease of maintenance and reproduction compared to other organisms such as African clawed frog (Xenopus laevis) or zebrafish (Danio rerio), which are relatively difficult to study. The main purposes of this review are the definition and origin of the axolotl, its taxonomy, anatomy, reproduction, nutrition, habitat, to give a perspective to scientists who want to work on this model organism by giving examples to the scientific data and study fields of the last 20 years by addressing issues such as how it contributes to scientific studies as a model organism.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c9b969440e39ac1703a94e5786768d3a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951703,"asset_id":120960177,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951703/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960177"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960177"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960177; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960177]").text(description); $(".js-view-count[data-work-id=120960177]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960177; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960177']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c9b969440e39ac1703a94e5786768d3a" } } $('.js-work-strip[data-work-id=120960177]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960177,"title":"Rejeneratif tıpta model organizma; Aksolotl (Ambystoma Mexicanum)","translated_title":"","metadata":{"ai_title_tag":"Axolotl as a Model Organism in Regenerative Medicine","grobid_abstract":"The axolotl has an extraordinary capacity to regenerate damaged and lost structures, especially the nervous system, limbs, organs such as the eye and heart, without causing scarring. It has become a very important model organism by attracting the attention of scientists working in both developmental biology and regenerative medicine and stem cell biology. The axolotl, which is amphibian and tetrapod, is a more preferred model due to its ease of maintenance and reproduction compared to other organisms such as African clawed frog (Xenopus laevis) or zebrafish (Danio rerio), which are relatively difficult to study. The main purposes of this review are the definition and origin of the axolotl, its taxonomy, anatomy, reproduction, nutrition, habitat, to give a perspective to scientists who want to work on this model organism by giving examples to the scientific data and study fields of the last 20 years by addressing issues such as how it contributes to scientific studies as a model organism.","publication_date":{"day":15,"month":3,"year":2022,"errors":{}},"publication_name":"Ege Tıp Dergisi","grobid_abstract_attachment_id":115951703},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960177/Rejeneratif_t%C4%B1pta_model_organizma_Aksolotl_Ambystoma_Mexicanum_","translated_internal_url":"","created_at":"2024-06-13T04:02:23.911-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951703,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951703/thumbnails/1.jpg","file_name":"2304001.pdf","download_url":"https://www.academia.edu/attachments/115951703/download_file","bulk_download_file_name":"Rejeneratif_tipta_model_organizma_Aksolo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951703/2304001-libre.pdf?1718278706=\u0026response-content-disposition=attachment%3B+filename%3DRejeneratif_tipta_model_organizma_Aksolo.pdf\u0026Expires=1743662386\u0026Signature=X9WLwfiIFaS48tgligngrdyfjbZ6OQzAng0BqKbFpwMxNAUOdXycGbC3sHBuJ0SvJ6oOwphQqdr98uKfhPF1EhpCDHiIIqQ~BCIwUrfjCf4tASMZl1LaeyWn92-znNz9x2JLRnhfdsZV~g7q-iMZl9jH4-YVb-yHrIseGsJx~DYJWsZmFnu9qW-vbgoCeA4iSwX6ktCVBcdDedssT702QO8SFKcfLpJ5TfdpOozJC9w7EVKqnQKgS1dsOzwFttmNjie50LDHFITvR~sIMcuX9XzlUqTWww0BosLbGEEl6ZIUpvawCMHO-Ui9uH2XwklOOEigde-v14syLuu8HaTIOg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Rejeneratif_tıpta_model_organizma_Aksolotl_Ambystoma_Mexicanum_","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"The axolotl has an extraordinary capacity to regenerate damaged and lost structures, especially the nervous system, limbs, organs such as the eye and heart, without causing scarring. It has become a very important model organism by attracting the attention of scientists working in both developmental biology and regenerative medicine and stem cell biology. The axolotl, which is amphibian and tetrapod, is a more preferred model due to its ease of maintenance and reproduction compared to other organisms such as African clawed frog (Xenopus laevis) or zebrafish (Danio rerio), which are relatively difficult to study. 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Yöntemler: Çalışmamızda, %10'luk formaldehit ile tespit edilmiş, makroskobik patolojisi gözlenmeyen, doku bütünlüğü bozulmamış yetişkin kadavra beyin hemisferleri arasından elde edilen dokular kullanıldı. Beş kadavra beyninden alınan örneklerden üçü uygun boyama metoduna ulaşabilmek amacıyla kullanıldı. Doku fiksasyon metodu, Hematoksilen-eozin boyama metodu ve Luxol fast blue boyama metodu uygulandı. Bulgular: Histolojik olarak ilk defa corpus callosum (CC), indusium griseum (IG) ve stria longitudinalis (SL) aynı görüntü üzerinde tespit edildi. SL'in lifleri, vasküler ve morfolojik yapısı belirtildi. Sonuç: Umuyoruz ki, SL ile ilgili histolojik, immünohistokimyasal ve anatomik yaklaşımlar ışığında yaptığımız bu girişim, bu konu üzerindeki bazı karanlık yönleri aydınlatacaktır. Böylece bizden sonra SL üzerinde çalışacak araştırmacıların istifadesine sunulmak üzere akademik bir hafıza oluşturacaktır.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c25fbe33ee95eada9905940f12d6f91f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951702,"asset_id":120960176,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951702/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960176"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960176"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960176; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960176]").text(description); $(".js-view-count[data-work-id=120960176]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960176; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960176']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c25fbe33ee95eada9905940f12d6f91f" } } $('.js-work-strip[data-work-id=120960176]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960176,"title":"Stria longitudinalis medialis ve lateralis’in morfolojik olarak incelenmesi","translated_title":"","metadata":{"publisher":"Dicle University Medical School","grobid_abstract":"Amaç: Bu çalışmada, bilinen bazı boyama yöntemlerinin modifiye edilerek stria longitudinalis medialis ve lateralis'in histo-morfolojik olarak incelenmesi ve elde edilecek bulguların bundan sonra yapılacak olan benzer çalışmalara ışık tutması amaçlanmıştır. Yöntemler: Çalışmamızda, %10'luk formaldehit ile tespit edilmiş, makroskobik patolojisi gözlenmeyen, doku bütünlüğü bozulmamış yetişkin kadavra beyin hemisferleri arasından elde edilen dokular kullanıldı. Beş kadavra beyninden alınan örneklerden üçü uygun boyama metoduna ulaşabilmek amacıyla kullanıldı. Doku fiksasyon metodu, Hematoksilen-eozin boyama metodu ve Luxol fast blue boyama metodu uygulandı. Bulgular: Histolojik olarak ilk defa corpus callosum (CC), indusium griseum (IG) ve stria longitudinalis (SL) aynı görüntü üzerinde tespit edildi. SL'in lifleri, vasküler ve morfolojik yapısı belirtildi. Sonuç: Umuyoruz ki, SL ile ilgili histolojik, immünohistokimyasal ve anatomik yaklaşımlar ışığında yaptığımız bu girişim, bu konu üzerindeki bazı karanlık yönleri aydınlatacaktır. 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Four hemocytes types were identified; prohemocytes, plasmatocytes, granulocytes and eleocytes. They were characterized by light microscopy according to size, presence or absence of granules and nucleus/cytoplasm ratio. The prohemocytes were the smallest cells with large nuclei in the hemolymph. Plasmatocytes were polymorphic, varied from ovoid to spindle-shaped cells. Plasmatocytes were the most abundant hemocyte type in the hemolymph of H. medicinalis. Granulocytes were elliptical in shape and characterized by the presence of cytoplasmic granules. Eleocytes were spherical cells with homogeneous and slightly granular cytoplasm. The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960175"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960175"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960175; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960175]").text(description); $(".js-view-count[data-work-id=120960175]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960175; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960175']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960175]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960175,"title":"Microscopy Investigation of the Immune System Cells of Hirudo Medicinalis Linnaeus, 1758","translated_title":"","metadata":{"abstract":"The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinalis. 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The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical","publication_date":{"day":null,"month":null,"year":2017,"errors":{}}},"translated_abstract":"The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinalis. Four hemocytes types were identified; prohemocytes, plasmatocytes, granulocytes and eleocytes. They were characterized by light microscopy according to size, presence or absence of granules and nucleus/cytoplasm ratio. The prohemocytes were the smallest cells with large nuclei in the hemolymph. Plasmatocytes were polymorphic, varied from ovoid to spindle-shaped cells. Plasmatocytes were the most abundant hemocyte type in the hemolymph of H. medicinalis. Granulocytes were elliptical in shape and characterized by the presence of cytoplasmic granules. Eleocytes were spherical cells with homogeneous and slightly granular cytoplasm. The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical","internal_url":"https://www.academia.edu/120960175/Microscopy_Investigation_of_the_Immune_System_Cells_of_Hirudo_Medicinalis_Linnaeus_1758","translated_internal_url":"","created_at":"2024-06-13T04:02:23.107-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Microscopy_Investigation_of_the_Immune_System_Cells_of_Hirudo_Medicinalis_Linnaeus_1758","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinalis. Four hemocytes types were identified; prohemocytes, plasmatocytes, granulocytes and eleocytes. They were characterized by light microscopy according to size, presence or absence of granules and nucleus/cytoplasm ratio. The prohemocytes were the smallest cells with large nuclei in the hemolymph. Plasmatocytes were polymorphic, varied from ovoid to spindle-shaped cells. Plasmatocytes were the most abundant hemocyte type in the hemolymph of H. medicinalis. Granulocytes were elliptical in shape and characterized by the presence of cytoplasmic granules. Eleocytes were spherical cells with homogeneous and slightly granular cytoplasm. The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":955941,"name":"Hirudo Medicinalis","url":"https://www.academia.edu/Documents/in/Hirudo_Medicinalis"}],"urls":[{"id":42903031,"url":"https://avesis.ege.edu.tr/yayin/816059e5-a614-4104-a6a2-ddd9b7308111/microscopy-investigation-of-the-immune-system-cells-of-hirudo-medicinalis-linnaeus-1758"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960175-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960174"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960174/Review_paper_Neural_stem_cell_therapy_in_neurological_diseases"><img alt="Research paper thumbnail of Review paper Neural stem cell therapy in neurological diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/115951700/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960174/Review_paper_Neural_stem_cell_therapy_in_neurological_diseases">Review paper Neural stem cell therapy in neurological diseases</a></div><div class="wp-workCard_item"><span>Archives of Medical Science</span><span>, Oct 22, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Early developmental process of mammalian embryo is almost completely directed by the behavior of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural stem cells has brought novel approaches as to the use of stem cells in the treatment of some neurodegenerative disorders such as Parkinson, Alzheimer disease and amyotrophic lateral sclerosis, as well as in the management of spinal cord injuries. However, scientific literature requires detailed information regarding the proliferation and differentiation of stem cells and the mechanisms controlling the migration of these cells to the targeted central nervous system site. Development of new therapeutic protocols using stem cells and their effective clinical application in the future would bring light to cope with a number of systemic diseases, especially neurological disorders. This review has considered the biological features of stem cells, stem cell plasticity, potential application of stem cells in neurological diseases and cancer, highlighting the promises as well as the problems of this treatment approach.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ac9aadbe2ab157fc2f35cd99a5461eb9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951700,"asset_id":120960174,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951700/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960174"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960174"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960174; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960174]").text(description); $(".js-view-count[data-work-id=120960174]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960174; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960174']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ac9aadbe2ab157fc2f35cd99a5461eb9" } } $('.js-work-strip[data-work-id=120960174]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960174,"title":"Review paper Neural stem cell therapy in neurological diseases","translated_title":"","metadata":{"publisher":"Termedia Publishing House","grobid_abstract":"Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. 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This review has considered the biological features of stem cells, stem cell plasticity, potential application of stem cells in neurological diseases and cancer, highlighting the promises as well as the problems of this treatment approach.","publication_date":{"day":22,"month":10,"year":2009,"errors":{}},"publication_name":"Archives of Medical Science","grobid_abstract_attachment_id":115951700},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960174/Review_paper_Neural_stem_cell_therapy_in_neurological_diseases","translated_internal_url":"","created_at":"2024-06-13T04:02:22.836-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951700/thumbnails/1.jpg","file_name":"pdf-13453-1.pdf","download_url":"https://www.academia.edu/attachments/115951700/download_file","bulk_download_file_name":"Review_paper_Neural_stem_cell_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951700/pdf-13453-1-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DReview_paper_Neural_stem_cell_therapy_in.pdf\u0026Expires=1743662386\u0026Signature=fS5~KBX5ZSUbEGDMLCMKdJQSqS0vBtEmLdijnrZHxhp-t3nYFUD2x9YQsdrpCTI2GSz2A85RLTashnVOWdhB952lpFTZcyDQNpXe5gCdqGkwL~a5sd2IZmvqSJmUA1nTSI79kKs60kLQdDRfbg6HLDsCukwNA21eqcw-6ykVRtJJ5IxAesKy3DTk2MVL8zW5ScExw3XJLhpWY35TW3VzpkNDoDpC-FOXRqbU8y-g0IN6aR36gW1BzHkleKb8rrF0zEURTa0H84TOa-wz1mVgNohLv68Uedgxi9Sd~fD2Ee8adFUPhi-N9nM-D2lmz1Rq85mq58RKFovOXypyaIe5aA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Review_paper_Neural_stem_cell_therapy_in_neurological_diseases","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural stem cells has brought novel approaches as to the use of stem cells in the treatment of some neurodegenerative disorders such as Parkinson, Alzheimer disease and amyotrophic lateral sclerosis, as well as in the management of spinal cord injuries. However, scientific literature requires detailed information regarding the proliferation and differentiation of stem cells and the mechanisms controlling the migration of these cells to the targeted central nervous system site. Development of new therapeutic protocols using stem cells and their effective clinical application in the future would bring light to cope with a number of systemic diseases, especially neurological disorders. This review has considered the biological features of stem cells, stem cell plasticity, potential application of stem cells in neurological diseases and cancer, highlighting the promises as well as the problems of this treatment approach.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951700/thumbnails/1.jpg","file_name":"pdf-13453-1.pdf","download_url":"https://www.academia.edu/attachments/115951700/download_file","bulk_download_file_name":"Review_paper_Neural_stem_cell_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951700/pdf-13453-1-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DReview_paper_Neural_stem_cell_therapy_in.pdf\u0026Expires=1743662386\u0026Signature=fS5~KBX5ZSUbEGDMLCMKdJQSqS0vBtEmLdijnrZHxhp-t3nYFUD2x9YQsdrpCTI2GSz2A85RLTashnVOWdhB952lpFTZcyDQNpXe5gCdqGkwL~a5sd2IZmvqSJmUA1nTSI79kKs60kLQdDRfbg6HLDsCukwNA21eqcw-6ykVRtJJ5IxAesKy3DTk2MVL8zW5ScExw3XJLhpWY35TW3VzpkNDoDpC-FOXRqbU8y-g0IN6aR36gW1BzHkleKb8rrF0zEURTa0H84TOa-wz1mVgNohLv68Uedgxi9Sd~fD2Ee8adFUPhi-N9nM-D2lmz1Rq85mq58RKFovOXypyaIe5aA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951699,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951699/thumbnails/1.jpg","file_name":"pdf-13453-1.pdf","download_url":"https://www.academia.edu/attachments/115951699/download_file","bulk_download_file_name":"Review_paper_Neural_stem_cell_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951699/pdf-13453-1-libre.pdf?1718278700=\u0026response-content-disposition=attachment%3B+filename%3DReview_paper_Neural_stem_cell_therapy_in.pdf\u0026Expires=1743662386\u0026Signature=eemLQ-lFn~B8kPlpkPSqnGQDwMFA9lYxyfIkSPZ~qZChMd6CBM6gQmed6GWnZTrqPRTnmR0yMPcNLQmgXnA0ClEP9ow4sS1usTu50Djx0odoVpjrkag5YLK7jP0dBjoOiyQWE-EtS7syIWGC29NYUh-H7e0PJJhmBtT1qUgns5KAdEBxPLTQtk0u4OVBoUrG57XZCDxDnTFNESWq3k8YMa1sUbliN5QcEFp7B6t0cg1dHLh5JgLcfdEGRCKawy0CQ81pcATmef5JGcxcN8joRbYS4nPiPmDj6O8ip085UAkkWcMT~yjJP52OS1-UdkgTdRjckpM-4ELaLN9ijMnHjw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37853,"name":"Stem cell Therapy","url":"https://www.academia.edu/Documents/in/Stem_cell_Therapy"},{"id":57148,"name":"Neural stem cell","url":"https://www.academia.edu/Documents/in/Neural_stem_cell"}],"urls":[{"id":42903030,"url":"https://www.termedia.pl/Journal/-19/pdf-13453-1?filename=Neural%20stem.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960174-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960173"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960173/Histological_and_Immunological_Evaluation_of_the_Osteogenic_Effects_of_Compact_Bone_Delivered_Stem_Cell_on_Spongiosis_Bone_in_the_Rat_Zygomatic_Arch_Defect_Model"><img alt="Research paper thumbnail of Histological and Immunological Evaluation of the Osteogenic Effects of Compact Bone-Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Histological and Immunological Evaluation of the Osteogenic Effects of Compact Bone-Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model</div><div class="wp-workCard_item"><span>PubMed</span><span>, Sep 1, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P > 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P < 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P < 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P > 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P < 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P > 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960173]").text(description); $(".js-view-count[data-work-id=120960173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960173,"title":"Histological and Immunological Evaluation of the Osteogenic Effects of Compact Bone-Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model","translated_title":"","metadata":{"abstract":"Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P \u003e 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P \u003c 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P \u003c 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P \u003e 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P \u003c 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P \u003e 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.","publication_date":{"day":1,"month":9,"year":2023,"errors":{}},"publication_name":"PubMed"},"translated_abstract":"Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P \u003e 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P \u003c 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P \u003c 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P \u003e 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P \u003c 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P \u003e 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.","internal_url":"https://www.academia.edu/120960173/Histological_and_Immunological_Evaluation_of_the_Osteogenic_Effects_of_Compact_Bone_Delivered_Stem_Cell_on_Spongiosis_Bone_in_the_Rat_Zygomatic_Arch_Defect_Model","translated_internal_url":"","created_at":"2024-06-13T04:02:22.617-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Histological_and_Immunological_Evaluation_of_the_Osteogenic_Effects_of_Compact_Bone_Delivered_Stem_Cell_on_Spongiosis_Bone_in_the_Rat_Zygomatic_Arch_Defect_Model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P \u003e 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P \u003c 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P \u003c 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P \u003e 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P \u003c 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P \u003e 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[],"research_interests":[{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":190152,"name":"Osteocyte","url":"https://www.academia.edu/Documents/in/Osteocyte"},{"id":203376,"name":"Osteopontin","url":"https://www.academia.edu/Documents/in/Osteopontin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":2929995,"name":"zygomatic bone","url":"https://www.academia.edu/Documents/in/zygomatic_bone"}],"urls":[{"id":42903029,"url":"https://pubmed.ncbi.nlm.nih.gov/37566821"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960173-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960172/_sup_99m_sup_Tc_Technetium_Labeled_Niosomes_Radiolabeling_Quality_Control_and_i_In_Vitro_i_Evaluation"><img alt="Research paper thumbnail of [<sup>99m</sup>Tc]Technetium-Labeled Niosomes: Radiolabeling, Quality Control, and <i>In Vitro</i> Evaluation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">[<sup>99m</sup>Tc]Technetium-Labeled Niosomes: Radiolabeling, Quality Control, and <i>In Vitro</i> Evaluation</div><div class="wp-workCard_item"><span>ACS omega</span><span>, Feb 8, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960172; 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CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960168"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960168; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960168]").text(description); $(".js-view-count[data-work-id=120960168]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960168; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960168']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960168]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960168,"title":"The protective effect of exogen melatonin upon fetal hippocampus damage caused by high-dose caffeine administration in pregnant rats","translated_title":"","metadata":{"abstract":"Objective: Caffeine (CAF), which is in the methylxanthines group (1,3,7-trimethylxanthine), is a neurologically active food component that is widely consumed and has a stimulating effect on the central nervous system. CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...","publisher":"Research Square Platform LLC"},"translated_abstract":"Objective: Caffeine (CAF), which is in the methylxanthines group (1,3,7-trimethylxanthine), is a neurologically active food component that is widely consumed and has a stimulating effect on the central nervous system. CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...","internal_url":"https://www.academia.edu/120960168/The_protective_effect_of_exogen_melatonin_upon_fetal_hippocampus_damage_caused_by_high_dose_caffeine_administration_in_pregnant_rats","translated_internal_url":"","created_at":"2024-06-13T04:02:21.651-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_protective_effect_of_exogen_melatonin_upon_fetal_hippocampus_damage_caused_by_high_dose_caffeine_administration_in_pregnant_rats","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Objective: Caffeine (CAF), which is in the methylxanthines group (1,3,7-trimethylxanthine), is a neurologically active food component that is widely consumed and has a stimulating effect on the central nervous system. CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51570,"name":"Melatonin","url":"https://www.academia.edu/Documents/in/Melatonin"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":67129,"name":"Caffeine","url":"https://www.academia.edu/Documents/in/Caffeine"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":181597,"name":"Root-Mean Square Error","url":"https://www.academia.edu/Documents/in/Root-Mean_Square_Error"},{"id":613283,"name":"Pineal Gland","url":"https://www.academia.edu/Documents/in/Pineal_Gland"},{"id":770944,"name":"Fetus","url":"https://www.academia.edu/Documents/in/Fetus"},{"id":4151399,"name":"Root mean square error","url":"https://www.academia.edu/Documents/in/Root_mean_square_error"}],"urls":[{"id":42903025,"url":"https://www.researchsquare.com/article/rs-2709866/v1"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960168-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960167"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960167/Evaluation_of_In_Vivo_Biological_Activity_Profiles_of_Isoindole_1_3_dione_Derivatives_Cytotoxicity_Toxicology_and_Histopathology_Studies"><img alt="Research paper thumbnail of Evaluation of In Vivo Biological Activity Profiles of Isoindole-1,3-dione Derivatives: Cytotoxicity, Toxicology, and Histopathology Studies" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Evaluation of In Vivo Biological Activity Profiles of Isoindole-1,3-dione Derivatives: Cytotoxicity, Toxicology, and Histopathology Studies</div><div class="wp-workCard_item"><span>ACS Omega</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960167"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960167"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960167; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960167-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960166"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960166/The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats"><img alt="Research paper thumbnail of The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/115951746/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960166/The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats">The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats</a></div><div class="wp-workCard_item"><span>Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DN...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 μg/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. It was concluded that PS may trigger dysregulation...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9ae7076148249cbe3b9a0f73484a412" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951746,"asset_id":120960166,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951746/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960166"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960166"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960166; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960166]").text(description); $(".js-view-count[data-work-id=120960166]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960166; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960166']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b9ae7076148249cbe3b9a0f73484a412" } } $('.js-work-strip[data-work-id=120960166]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960166,"title":"The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 μg/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. It was concluded that PS may trigger dysregulation...","publisher":"Erzincan Universitesi Fen Bilimleri Ensitusu Dergisi","publication_name":"Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi"},"translated_abstract":"The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 μg/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. It was concluded that PS may trigger dysregulation...","internal_url":"https://www.academia.edu/120960166/The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats","translated_internal_url":"","created_at":"2024-06-13T04:02:21.304-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951746,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951746/thumbnails/1.jpg","file_name":"2469932.pdf","download_url":"https://www.academia.edu/attachments/115951746/download_file","bulk_download_file_name":"The_Effects_of_Prenatal_Stress_on_Cortic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951746/2469932-libre.pdf?1718278699=\u0026response-content-disposition=attachment%3B+filename%3DThe_Effects_of_Prenatal_Stress_on_Cortic.pdf\u0026Expires=1743662387\u0026Signature=CAiUu4BZRyDxiKssYZvDYS0aMLbS5eaZlExafwUKe8ckIUJfzrKh8u5SYOhIcvR7WTJtQSFjzoFthgSq5LKCZShq67oNvTzgtu7MfZCkRIdpVbhOVj92yDpl9r09i5opfmBgRDGAjpv79QdL~aZckPlo-1XiL5CC4Xw7y3-J5vw4rSVTwQRYZVbvHZ-ANbZnSjtb3l39sAEQh5hv-qca8rwrnqv-zMBZtGbJoLQuHk2t6nTRZRdUTjX2KEq477yJzoTeOoSsGnVhtJNjvjIHjL02FJu7NnJUO4NdnWIqwmXpR2MM1tz67bVtCPUY4P5TpcbibvxQ34uw2taT~nDghQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats","translated_slug":"","page_count":13,"language":"en","content_type":"Work","summary":"The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 μg/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. It was concluded that PS may trigger dysregulation...","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951746,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951746/thumbnails/1.jpg","file_name":"2469932.pdf","download_url":"https://www.academia.edu/attachments/115951746/download_file","bulk_download_file_name":"The_Effects_of_Prenatal_Stress_on_Cortic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951746/2469932-libre.pdf?1718278699=\u0026response-content-disposition=attachment%3B+filename%3DThe_Effects_of_Prenatal_Stress_on_Cortic.pdf\u0026Expires=1743662387\u0026Signature=CAiUu4BZRyDxiKssYZvDYS0aMLbS5eaZlExafwUKe8ckIUJfzrKh8u5SYOhIcvR7WTJtQSFjzoFthgSq5LKCZShq67oNvTzgtu7MfZCkRIdpVbhOVj92yDpl9r09i5opfmBgRDGAjpv79QdL~aZckPlo-1XiL5CC4Xw7y3-J5vw4rSVTwQRYZVbvHZ-ANbZnSjtb3l39sAEQh5hv-qca8rwrnqv-zMBZtGbJoLQuHk2t6nTRZRdUTjX2KEq477yJzoTeOoSsGnVhtJNjvjIHjL02FJu7NnJUO4NdnWIqwmXpR2MM1tz67bVtCPUY4P5TpcbibvxQ34uw2taT~nDghQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":57556,"name":"Hippocampus","url":"https://www.academia.edu/Documents/in/Hippocampus"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":100277,"name":"HIstone Deacetylase","url":"https://www.academia.edu/Documents/in/HIstone_Deacetylase"},{"id":242709,"name":"Prenatal Stress","url":"https://www.academia.edu/Documents/in/Prenatal_Stress"},{"id":1581102,"name":"Methyltransferase","url":"https://www.academia.edu/Documents/in/Methyltransferase"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960166-figures'); } }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="6640885" id="papers"><div class="js-work-strip profile--work_container" data-work-id="123614068"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/123614068/Obituary_Professor_Dr_Meral_Baka_1955_2024_"><img alt="Research paper thumbnail of Obituary: Professor Dr. Meral Baka (1955–2024)" class="work-thumbnail" src="https://attachments.academia-assets.com/118005456/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/123614068/Obituary_Professor_Dr_Meral_Baka_1955_2024_">Obituary: Professor Dr. Meral Baka (1955–2024)</a></div><div class="wp-workCard_item"><span>Child's nervous system</span><span>, Mar 13, 2024</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b677c5f28420f077ff877f81a88ce0dd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":118005456,"asset_id":123614068,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/118005456/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="123614068"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="123614068"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 123614068; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-123614068-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960186"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960186/%C4%B0ntrabdominal_Adezyon_Olu%C5%9Fum_Mekanizmalar%C4%B1na_ve_Tedavi_Stratejilerine_Histopatolojik_Bak%C4%B1%C5%9F"><img alt="Research paper thumbnail of İntrabdominal Adezyon Oluşum Mekanizmalarına ve Tedavi Stratejilerine Histopatolojik Bakış" class="work-thumbnail" src="https://attachments.academia-assets.com/115951712/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960186/%C4%B0ntrabdominal_Adezyon_Olu%C5%9Fum_Mekanizmalar%C4%B1na_ve_Tedavi_Stratejilerine_Histopatolojik_Bak%C4%B1%C5%9F">İntrabdominal Adezyon Oluşum Mekanizmalarına ve Tedavi Stratejilerine Histopatolojik Bakış</a></div><div class="wp-workCard_item"><span>Arsiv Kaynak Tarama Dergisi</span><span>, Dec 30, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Intraabdominal adhesions are an important health problem that is seen in the postoperative period...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Intraabdominal adhesions are an important health problem that is seen in the postoperative period and negatively affects the quality of life. Chemical and thermal factors that occur in the peritoneal cavity and serosal surfaces, causing abdominal trauma, or infection and foreign body reactions may cause adhesion formation. Although the classification of intraabdominal adhesions is generally based on adhesion density and severity of prognosis, there is not yet a worldwide accepted standard classification system. Intraabdominal adhesions show clinical reflections with negative consequences such as pain, infertility, prolonged hospital stay after surgery and economic burden. In conclusion, adhesions encountered in the postoperative period are a serious problem and further studies should be adapted from laboratory environment to clinical research models in order to prevent adhesion formation. This review was prepared to review the literature on intraabdominal adhesion formation, histopathology, grading, prevention and clinical significance.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5379ad0701d6d388c9557fe79fe59832" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951712,"asset_id":120960186,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951712/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960186"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960186"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960186; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960186]").text(description); $(".js-view-count[data-work-id=120960186]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960186; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960186']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5379ad0701d6d388c9557fe79fe59832" } } $('.js-work-strip[data-work-id=120960186]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960186,"title":"İntrabdominal Adezyon Oluşum Mekanizmalarına ve Tedavi Stratejilerine Histopatolojik Bakış","translated_title":"","metadata":{"publisher":"Çukurova University Faculty of Medicine","grobid_abstract":"Intraabdominal adhesions are an important health problem that is seen in the postoperative period and negatively affects the quality of life. 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This review was prepared to review the literature on intraabdominal adhesion formation, histopathology, grading, prevention and clinical significance.","publication_date":{"day":30,"month":12,"year":2022,"errors":{}},"publication_name":"Arsiv Kaynak Tarama Dergisi","grobid_abstract_attachment_id":115951713},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960186/%C4%B0ntrabdominal_Adezyon_Olu%C5%9Fum_Mekanizmalar%C4%B1na_ve_Tedavi_Stratejilerine_Histopatolojik_Bak%C4%B1%C5%9F","translated_internal_url":"","created_at":"2024-06-13T04:02:30.509-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951712,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951712/thumbnails/1.jpg","file_name":"2428155.pdf","download_url":"https://www.academia.edu/attachments/115951712/download_file","bulk_download_file_name":"Intrabdominal_Adezyon_Olusum_Mekanizmala.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951712/2428155-libre.pdf?1718278713=\u0026response-content-disposition=attachment%3B+filename%3DIntrabdominal_Adezyon_Olusum_Mekanizmala.pdf\u0026Expires=1743662386\u0026Signature=JmlWH3OKdQ~ehFlOp70pdp8q0de3~VIM99w5tT0LWswD~13hAbgSt0V8ceBO0JKOmejeY~oI2S40OqN-hqywf6JxsRd17w6iQL0qkMG7ef0D6V1T-lTE93bFf0rSSeHwyu2mShrl7lduWutWq19L7~ctFMNt3u72NZWuhviPGWTzO0XiV~8kieQYVtqZi5WwcXZ2LRxgOpTXivAqLZys~5dv-TSpXZf8NtHEhK4CdmrUisDR1k7lVVFuSzMnKTw9V81uAnXMsL3ikpUbjcyzGDmcedriTBkk684EewjykYYJeEqUzFDV0pk9vbdd-jwbQw5YsjHBBASzUntr4zAtIg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"İntrabdominal_Adezyon_Oluşum_Mekanizmalarına_ve_Tedavi_Stratejilerine_Histopatolojik_Bakış","translated_slug":"","page_count":9,"language":"tr","content_type":"Work","summary":"Intraabdominal adhesions are an important health problem that is seen in the postoperative period and negatively affects the quality of life. Chemical and thermal factors that occur in the peritoneal cavity and serosal surfaces, causing abdominal trauma, or infection and foreign body reactions may cause adhesion formation. Although the classification of intraabdominal adhesions is generally based on adhesion density and severity of prognosis, there is not yet a worldwide accepted standard classification system. Intraabdominal adhesions show clinical reflections with negative consequences such as pain, infertility, prolonged hospital stay after surgery and economic burden. In conclusion, adhesions encountered in the postoperative period are a serious problem and further studies should be adapted from laboratory environment to clinical research models in order to prevent adhesion formation. This review was prepared to review the literature on intraabdominal adhesion formation, histopathology, grading, prevention and clinical significance.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951712,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951712/thumbnails/1.jpg","file_name":"2428155.pdf","download_url":"https://www.academia.edu/attachments/115951712/download_file","bulk_download_file_name":"Intrabdominal_Adezyon_Olusum_Mekanizmala.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951712/2428155-libre.pdf?1718278713=\u0026response-content-disposition=attachment%3B+filename%3DIntrabdominal_Adezyon_Olusum_Mekanizmala.pdf\u0026Expires=1743662386\u0026Signature=JmlWH3OKdQ~ehFlOp70pdp8q0de3~VIM99w5tT0LWswD~13hAbgSt0V8ceBO0JKOmejeY~oI2S40OqN-hqywf6JxsRd17w6iQL0qkMG7ef0D6V1T-lTE93bFf0rSSeHwyu2mShrl7lduWutWq19L7~ctFMNt3u72NZWuhviPGWTzO0XiV~8kieQYVtqZi5WwcXZ2LRxgOpTXivAqLZys~5dv-TSpXZf8NtHEhK4CdmrUisDR1k7lVVFuSzMnKTw9V81uAnXMsL3ikpUbjcyzGDmcedriTBkk684EewjykYYJeEqUzFDV0pk9vbdd-jwbQw5YsjHBBASzUntr4zAtIg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951713,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951713/thumbnails/1.jpg","file_name":"2428155.pdf","download_url":"https://www.academia.edu/attachments/115951713/download_file","bulk_download_file_name":"Intrabdominal_Adezyon_Olusum_Mekanizmala.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951713/2428155-libre.pdf?1718278716=\u0026response-content-disposition=attachment%3B+filename%3DIntrabdominal_Adezyon_Olusum_Mekanizmala.pdf\u0026Expires=1743662386\u0026Signature=C3RHF458J9H6YDgYYqJNenMFBVcghYhfzyCyXVdpnrAjqRotupfNLzsaK8VMhgeuKGZB3fCKZx1HzVgCP2YfWMrzbE-S4KFf-WL1oyyBJ6wNGppMJk2k-bcZsoT2WzFjCaIrflKTfJlsCsI~vzq5pI7uJo1B5NKZy9PP9IsGak1AI~dkvFe0GthhfKR5xjNpGev5766glQQTDsqxQwz-JYaitpJu3ORxIzrsgO1dW5QWvR3wgAlzALC39cLaZQqQh7hi6p2scLJW5b67~dkvmFGYsYBqTisfmYsSs-E56bEG1uk6O~ja4ESIObIpluUA4IutREbOXhAP147Fet4wCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"}],"urls":[{"id":42903041,"url":"https://dergipark.org.tr/tr/download/article-file/2428155"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960186-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960185"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960185/Histoloji_Laboratuvar_Uygulamalar%C4%B1"><img alt="Research paper thumbnail of Histoloji Laboratuvar Uygulamaları" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Histoloji Laboratuvar Uygulamaları</div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960185"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960185; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960185-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960183"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960183/S%C4%B1%C3%A7an_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_g%C3%B6sterilmesi"><img alt="Research paper thumbnail of Sıçan midesinde leptin ekspresyonunun immunohistokimyasal olarak gösterilmesi" class="work-thumbnail" src="https://attachments.academia-assets.com/115951711/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960183/S%C4%B1%C3%A7an_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_g%C3%B6sterilmesi">Sıçan midesinde leptin ekspresyonunun immunohistokimyasal olarak gösterilmesi</a></div><div class="wp-workCard_item"><span>Ege Tıp Dergisi</span><span>, Mar 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. Đlk olarak yağ dokus...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. Đlk olarak yağ dokusunda tanımlanan leptinin son zamanlarda vücutta çeşitli dokularda da ifade edildiği gözlenmiştir. Çeşitli çalışmalar leptinin midede de fonksiyon gösterebileceğini önermektedir. Bu çalışmada, sıçan mide dokusunda leptinin immünohistokimyasal dağılımını ve ifadesini araştırmak amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada 190-210 gr ağırlığında erkek sıçanlar kullanılmıştır. Işık mikroskopik incelemeler için Wistar albino 5 sıçan anastezi edilmiş ve heparinize edilip fosfat tamponlu % 4 paraformaldehit ile intrakardiyak perfüze edilmiştir. Rutin histolojik takip uygulanan mide dokusu daha sonra 5 µm kalınlıkta kesilip Leptin immunohistokimyasal boyaması yapılmıştır. Bulgular: Midenin fundus bölgesinde leptin (+) boyanan gerek esas hücre, gerekse pariyetal hücre sayısı korpus bölgesine oranla anlamlı derecede artmış bulundu. Korpustaki leptin (+) hücreler kıyaslandığında esas hücre ve pariyetal hücre sayıları arasında anlamlı bir fark saptanmadı; diğer taraftan fundustaki leptin (+) esas hücre sayısının leptin (+) pariyetal hücre sayısından anlamlı şekilde fazla olduğu gözlendi. Ayrıca, myenterik pleksusta boyanma gözlemlendi. Sonuç:Bu çalışmada diğer çalışmalardan farklı olarak temel olarak gastrointestinal hareketleri kontrol eden myenterik pleksusda da leptinin varlığı gösterilmektedir. Leptinin sinerjistik etki gösterip beslenmenin düzenlenmesinde kısa süreli regülasyon ve/veya uzun süreli regülasyonda rol oynayabileceği gösterilmektedir.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7432f4df4c3032b8fa6ea1854cf92f2b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951711,"asset_id":120960183,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951711/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960183"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960183"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960183; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960183]").text(description); $(".js-view-count[data-work-id=120960183]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960183; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960183']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7432f4df4c3032b8fa6ea1854cf92f2b" } } $('.js-work-strip[data-work-id=120960183]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960183,"title":"Sıçan midesinde leptin ekspresyonunun immunohistokimyasal olarak gösterilmesi","translated_title":"","metadata":{"grobid_abstract":"Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. Đlk olarak yağ dokusunda tanımlanan leptinin son zamanlarda vücutta çeşitli dokularda da ifade edildiği gözlenmiştir. Çeşitli çalışmalar leptinin midede de fonksiyon gösterebileceğini önermektedir. Bu çalışmada, sıçan mide dokusunda leptinin immünohistokimyasal dağılımını ve ifadesini araştırmak amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada 190-210 gr ağırlığında erkek sıçanlar kullanılmıştır. Işık mikroskopik incelemeler için Wistar albino 5 sıçan anastezi edilmiş ve heparinize edilip fosfat tamponlu % 4 paraformaldehit ile intrakardiyak perfüze edilmiştir. Rutin histolojik takip uygulanan mide dokusu daha sonra 5 µm kalınlıkta kesilip Leptin immunohistokimyasal boyaması yapılmıştır. Bulgular: Midenin fundus bölgesinde leptin (+) boyanan gerek esas hücre, gerekse pariyetal hücre sayısı korpus bölgesine oranla anlamlı derecede artmış bulundu. Korpustaki leptin (+) hücreler kıyaslandığında esas hücre ve pariyetal hücre sayıları arasında anlamlı bir fark saptanmadı; diğer taraftan fundustaki leptin (+) esas hücre sayısının leptin (+) pariyetal hücre sayısından anlamlı şekilde fazla olduğu gözlendi. Ayrıca, myenterik pleksusta boyanma gözlemlendi. Sonuç:Bu çalışmada diğer çalışmalardan farklı olarak temel olarak gastrointestinal hareketleri kontrol eden myenterik pleksusda da leptinin varlığı gösterilmektedir. Leptinin sinerjistik etki gösterip beslenmenin düzenlenmesinde kısa süreli regülasyon ve/veya uzun süreli regülasyonda rol oynayabileceği gösterilmektedir.","publication_date":{"day":1,"month":3,"year":2009,"errors":{}},"publication_name":"Ege Tıp Dergisi","grobid_abstract_attachment_id":115951711},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960183/S%C4%B1%C3%A7an_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_g%C3%B6sterilmesi","translated_internal_url":"","created_at":"2024-06-13T04:02:28.341-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951711,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951711/thumbnails/1.jpg","file_name":"350362.pdf","download_url":"https://www.academia.edu/attachments/115951711/download_file","bulk_download_file_name":"Sican_midesinde_leptin_ekspresyonunun_im.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951711/350362-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DSican_midesinde_leptin_ekspresyonunun_im.pdf\u0026Expires=1743662386\u0026Signature=GwWBwp6HBjw6WYYf12J3nOL6HY-Q8w~qxKJbslj998GxfhXZLu69K8iI2o4f7bQsjdCb5VzdHlE9J7MThAe6tE1m7yR5E4PxXTsCfK3fBd4P5OgqyhVbJOmTV8UQwlFhOcyAFsa7P5sdkJwARi14xTh6giMobF~zkkAOzbVawkM-kevSCsdv9MhFtaFA5jlIoF~RDdYJMxpXqI1P-CvDv3FlrS0GlJLeyw0rGJnQxXsvWwx-bu~3hIvlgSmER7l8jas4uylBATLP5nXRhK4D-9H7cer0Drs6KeDd0PrW8WZrQZLbwaeuLaET-iIoSOvd2z~Bgwy2CUJ1lG~3vp6N-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Sıçan_midesinde_leptin_ekspresyonunun_immunohistokimyasal_olarak_gösterilmesi","translated_slug":"","page_count":6,"language":"tr","content_type":"Work","summary":"Giriş: Leptin, ob gen tarafından kodlanan 16-kDa ağırlığında bir moleküldür. Đlk olarak yağ dokusunda tanımlanan leptinin son zamanlarda vücutta çeşitli dokularda da ifade edildiği gözlenmiştir. Çeşitli çalışmalar leptinin midede de fonksiyon gösterebileceğini önermektedir. Bu çalışmada, sıçan mide dokusunda leptinin immünohistokimyasal dağılımını ve ifadesini araştırmak amaçlanmıştır. Gereç ve Yöntem: Bu çalışmada 190-210 gr ağırlığında erkek sıçanlar kullanılmıştır. Işık mikroskopik incelemeler için Wistar albino 5 sıçan anastezi edilmiş ve heparinize edilip fosfat tamponlu % 4 paraformaldehit ile intrakardiyak perfüze edilmiştir. Rutin histolojik takip uygulanan mide dokusu daha sonra 5 µm kalınlıkta kesilip Leptin immunohistokimyasal boyaması yapılmıştır. Bulgular: Midenin fundus bölgesinde leptin (+) boyanan gerek esas hücre, gerekse pariyetal hücre sayısı korpus bölgesine oranla anlamlı derecede artmış bulundu. Korpustaki leptin (+) hücreler kıyaslandığında esas hücre ve pariyetal hücre sayıları arasında anlamlı bir fark saptanmadı; diğer taraftan fundustaki leptin (+) esas hücre sayısının leptin (+) pariyetal hücre sayısından anlamlı şekilde fazla olduğu gözlendi. Ayrıca, myenterik pleksusta boyanma gözlemlendi. Sonuç:Bu çalışmada diğer çalışmalardan farklı olarak temel olarak gastrointestinal hareketleri kontrol eden myenterik pleksusda da leptinin varlığı gösterilmektedir. Leptinin sinerjistik etki gösterip beslenmenin düzenlenmesinde kısa süreli regülasyon ve/veya uzun süreli regülasyonda rol oynayabileceği gösterilmektedir.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951711,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951711/thumbnails/1.jpg","file_name":"350362.pdf","download_url":"https://www.academia.edu/attachments/115951711/download_file","bulk_download_file_name":"Sican_midesinde_leptin_ekspresyonunun_im.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951711/350362-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DSican_midesinde_leptin_ekspresyonunun_im.pdf\u0026Expires=1743662386\u0026Signature=GwWBwp6HBjw6WYYf12J3nOL6HY-Q8w~qxKJbslj998GxfhXZLu69K8iI2o4f7bQsjdCb5VzdHlE9J7MThAe6tE1m7yR5E4PxXTsCfK3fBd4P5OgqyhVbJOmTV8UQwlFhOcyAFsa7P5sdkJwARi14xTh6giMobF~zkkAOzbVawkM-kevSCsdv9MhFtaFA5jlIoF~RDdYJMxpXqI1P-CvDv3FlrS0GlJLeyw0rGJnQxXsvWwx-bu~3hIvlgSmER7l8jas4uylBATLP5nXRhK4D-9H7cer0Drs6KeDd0PrW8WZrQZLbwaeuLaET-iIoSOvd2z~Bgwy2CUJ1lG~3vp6N-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951710,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951710/thumbnails/1.jpg","file_name":"350362.pdf","download_url":"https://www.academia.edu/attachments/115951710/download_file","bulk_download_file_name":"Sican_midesinde_leptin_ekspresyonunun_im.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951710/350362-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DSican_midesinde_leptin_ekspresyonunun_im.pdf\u0026Expires=1743662386\u0026Signature=AljYeiXvpBYxWkj3AWtf8eXI7pNpSvXJkK1rGrdDSS5sB3EMAJObfqoKp9AcPf3XsXZ4eVmWyHrUvb~rP0Uc0GO4vakKsjAA9b~6jeWw2qR47DvAiI1Efjl~lwf4fZr94eZQmxHWJcgENEyJni3r~4zgBYMnPHoh0UHrqHNlToIkbbdT6MES5wy~iicS2aTpbUZoqyAxJc~7ZDwUrubI6A7xfytJq1GJRZE8sL6TL3gTnMEhc8warrzT~JpofcISIEFtPkW9w0xMc2fRuyX1dogURSdUbsPSkzkIdRtmfPPASXK9QYQYd44qPSLCspY7ORD1SHpoxy~lJoeeqlrviw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":135357,"name":"Leptin","url":"https://www.academia.edu/Documents/in/Leptin"}],"urls":[{"id":42903039,"url":"https://egetipdergisi.com.tr/tr/download/article-file/350362"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960183-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960182"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960182/Investigation_of_the_combination_of_anti_PD_L1_mAb_with_HER2_neu_loaded_dendritic_cells_and_QS_21_saponin_adjuvant_effect_against_HER2_positive_breast_cancer_in_mice"><img alt="Research paper thumbnail of Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice" class="work-thumbnail" src="https://attachments.academia-assets.com/115951748/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960182/Investigation_of_the_combination_of_anti_PD_L1_mAb_with_HER2_neu_loaded_dendritic_cells_and_QS_21_saponin_adjuvant_effect_against_HER2_positive_breast_cancer_in_mice">Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice</a></div><div class="wp-workCard_item"><span>Immunopharmacology and Immunotoxicology</span><span>, Jun 9, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cance...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cancers including 25% of breast cancers. Since combination therapy consisting of multiple therapeutic approaches is considered a promising regimen, we examined combination treatment modalities in a xenograft model in Balb/c mice injected with 4T1-HER2 cells. We used HER2/neu-loaded bone marrow-derived dendritic cells (BM-DC's) along with anti-PD-L1 monoclonal antibody in a new combination immunotherapy model. Methods: The combination was composed of an active immunotherapy (i.e. BM-DC-based vaccine) designed to boost the immune response against target antigen and was augmented by using anti-PD-L1 mAb to prevent immune evasion by the xenografted tumors. The vaccine combination was further supported using a QS-21 saponin adjuvant and the immune response was evaluated. Results: Mice treated with HER2/neu-loaded BM-DCs, combined with QS-21 and anti-PD-L1 mAb had significantly decreased tumor sizes and their splenocytes had enhanced cytotoxic activity, based on the lactate dehydrogenase (LDH) assay, compared to vaccine and adjuvant groups alone. The same vaccination group demonstrated a remarkable increase in IFN-c secreting CD8þ T-cells analyzed by flow cytometry. ELISA data also revealed a significant increase in the serum anti-HER2 IgG1 response; in addition, there was significant splenocyte proliferation upon stimulation with antigen compared to vaccine and adjuvant groups. Consistently, a significant infiltration of CD4þ, CD8þ immune cells in and around the tumors was observed. Conclusions: Our data suggest that the BM-DC þ HER2/neu þ QS-21 þ anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="994b687f91f4f66bcc9f5883ffe1f864" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951748,"asset_id":120960182,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951748/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960182"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960182"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960182; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960182]").text(description); $(".js-view-count[data-work-id=120960182]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960182; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960182']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "994b687f91f4f66bcc9f5883ffe1f864" } } $('.js-work-strip[data-work-id=120960182]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960182,"title":"Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice","translated_title":"","metadata":{"publisher":"Informa","grobid_abstract":"Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cancers including 25% of breast cancers. Since combination therapy consisting of multiple therapeutic approaches is considered a promising regimen, we examined combination treatment modalities in a xenograft model in Balb/c mice injected with 4T1-HER2 cells. We used HER2/neu-loaded bone marrow-derived dendritic cells (BM-DC's) along with anti-PD-L1 monoclonal antibody in a new combination immunotherapy model. Methods: The combination was composed of an active immunotherapy (i.e. BM-DC-based vaccine) designed to boost the immune response against target antigen and was augmented by using anti-PD-L1 mAb to prevent immune evasion by the xenografted tumors. The vaccine combination was further supported using a QS-21 saponin adjuvant and the immune response was evaluated. Results: Mice treated with HER2/neu-loaded BM-DCs, combined with QS-21 and anti-PD-L1 mAb had significantly decreased tumor sizes and their splenocytes had enhanced cytotoxic activity, based on the lactate dehydrogenase (LDH) assay, compared to vaccine and adjuvant groups alone. The same vaccination group demonstrated a remarkable increase in IFN-c secreting CD8þ T-cells analyzed by flow cytometry. ELISA data also revealed a significant increase in the serum anti-HER2 IgG1 response; in addition, there was significant splenocyte proliferation upon stimulation with antigen compared to vaccine and adjuvant groups. Consistently, a significant infiltration of CD4þ, CD8þ immune cells in and around the tumors was observed. Conclusions: Our data suggest that the BM-DC þ HER2/neu þ QS-21 þ anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice.","publication_date":{"day":9,"month":6,"year":2020,"errors":{}},"publication_name":"Immunopharmacology and Immunotoxicology","grobid_abstract_attachment_id":115951748},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960182/Investigation_of_the_combination_of_anti_PD_L1_mAb_with_HER2_neu_loaded_dendritic_cells_and_QS_21_saponin_adjuvant_effect_against_HER2_positive_breast_cancer_in_mice","translated_internal_url":"","created_at":"2024-06-13T04:02:27.900-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951748,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951748/thumbnails/1.jpg","file_name":"08923973.2020.177564420240613-1-afz69k.pdf","download_url":"https://www.academia.edu/attachments/115951748/download_file","bulk_download_file_name":"Investigation_of_the_combination_of_anti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951748/08923973.2020.177564420240613-1-afz69k-libre.pdf?1718278704=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_the_combination_of_anti.pdf\u0026Expires=1743662386\u0026Signature=TShoF1j0Wcm0BwvXpiSAW~OBHFyyNQTKbVYsrnmHzE44NGxF0mliP19P3fXjNUU0XzKQaxgTpUQF1A3~Q7UL2l4iJyPhfpbH2mEsqMqM-I3P01NR84-PVFiBPC2XktcnAIBoZKK0~0fQ1T5vpN0bix0zITu9rwtgzlMxvsW~DxQt6MNBQgzz2KIueNGcQvRVWvbUdvpUXaljy90TqszejF3aIMEu7vekKzQcvjprbMaJGJL~UaNCjpQi1FmZyObIawmevp777F62grUv43rn-gKkMQAnzhTz0MdKwicqX2s92KqLOSZgM-UF80zvU257M-s8EgeFRenz7Ll9Eq2q3w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Investigation_of_the_combination_of_anti_PD_L1_mAb_with_HER2_neu_loaded_dendritic_cells_and_QS_21_saponin_adjuvant_effect_against_HER2_positive_breast_cancer_in_mice","translated_slug":"","page_count":13,"language":"en","content_type":"Work","summary":"Background: Human epidermal growth factor receptor 2 (HER2) is overexpressed in a subset of cancers including 25% of breast cancers. Since combination therapy consisting of multiple therapeutic approaches is considered a promising regimen, we examined combination treatment modalities in a xenograft model in Balb/c mice injected with 4T1-HER2 cells. We used HER2/neu-loaded bone marrow-derived dendritic cells (BM-DC's) along with anti-PD-L1 monoclonal antibody in a new combination immunotherapy model. Methods: The combination was composed of an active immunotherapy (i.e. BM-DC-based vaccine) designed to boost the immune response against target antigen and was augmented by using anti-PD-L1 mAb to prevent immune evasion by the xenografted tumors. The vaccine combination was further supported using a QS-21 saponin adjuvant and the immune response was evaluated. Results: Mice treated with HER2/neu-loaded BM-DCs, combined with QS-21 and anti-PD-L1 mAb had significantly decreased tumor sizes and their splenocytes had enhanced cytotoxic activity, based on the lactate dehydrogenase (LDH) assay, compared to vaccine and adjuvant groups alone. The same vaccination group demonstrated a remarkable increase in IFN-c secreting CD8þ T-cells analyzed by flow cytometry. ELISA data also revealed a significant increase in the serum anti-HER2 IgG1 response; in addition, there was significant splenocyte proliferation upon stimulation with antigen compared to vaccine and adjuvant groups. Consistently, a significant infiltration of CD4þ, CD8þ immune cells in and around the tumors was observed. Conclusions: Our data suggest that the BM-DC þ HER2/neu þ QS-21 þ anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951748,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951748/thumbnails/1.jpg","file_name":"08923973.2020.177564420240613-1-afz69k.pdf","download_url":"https://www.academia.edu/attachments/115951748/download_file","bulk_download_file_name":"Investigation_of_the_combination_of_anti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951748/08923973.2020.177564420240613-1-afz69k-libre.pdf?1718278704=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_the_combination_of_anti.pdf\u0026Expires=1743662386\u0026Signature=TShoF1j0Wcm0BwvXpiSAW~OBHFyyNQTKbVYsrnmHzE44NGxF0mliP19P3fXjNUU0XzKQaxgTpUQF1A3~Q7UL2l4iJyPhfpbH2mEsqMqM-I3P01NR84-PVFiBPC2XktcnAIBoZKK0~0fQ1T5vpN0bix0zITu9rwtgzlMxvsW~DxQt6MNBQgzz2KIueNGcQvRVWvbUdvpUXaljy90TqszejF3aIMEu7vekKzQcvjprbMaJGJL~UaNCjpQi1FmZyObIawmevp777F62grUv43rn-gKkMQAnzhTz0MdKwicqX2s92KqLOSZgM-UF80zvU257M-s8EgeFRenz7Ll9Eq2q3w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology"},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy"},{"id":153279,"name":"Dendritic cell","url":"https://www.academia.edu/Documents/in/Dendritic_cell"},{"id":216943,"name":"CD","url":"https://www.academia.edu/Documents/in/CD"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system"},{"id":809620,"name":"Saponin","url":"https://www.academia.edu/Documents/in/Saponin"},{"id":1485245,"name":"Adjuvant","url":"https://www.academia.edu/Documents/in/Adjuvant"}],"urls":[{"id":42903038,"url":"https://doi.org/10.1080/08923973.2020.1775644"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960182-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960181"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960181/Cellular_Signaling_Pathways_and_Their_Clinical_Reflections"><img alt="Research paper thumbnail of Cellular Signaling Pathways and Their Clinical Reflections" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Cellular Signaling Pathways and Their Clinical Reflections</div><div class="wp-workCard_item"><span>DOAJ (DOAJ: Directory of Open Access Journals)</span><span>, Jun 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cellular signaling pathways have important roles in cellular growth, differentiation, inflammator...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cellular signaling pathways have important roles in cellular growth, differentiation, inflammatory response and apoptosis and in regulation of cellular responses under various chemical stimulators. Different proteins which belong to these pathways may be exposed to loss-of-function or gain-of-function mutations; this may lead to many clinical phenotypes including primarily cancer. In this review information about basic working principles of these pathways and diseases related to them are included.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960181"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960181"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960181; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960181]").text(description); $(".js-view-count[data-work-id=120960181]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960181; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960181']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960181]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960181,"title":"Cellular Signaling Pathways and Their Clinical Reflections","translated_title":"","metadata":{"abstract":"Cellular signaling pathways have important roles in cellular growth, differentiation, inflammatory response and apoptosis and in regulation of cellular responses under various chemical stimulators. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960181-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960180"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960180/Di%C5%9F_Hekimli%C4%9Fi_i%C3%A7in_Anatominin_Temelleri"><img alt="Research paper thumbnail of Diş Hekimliği için Anatominin Temelleri" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Diş Hekimliği için Anatominin Temelleri</div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960180"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960180"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960180; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960180-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960179"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960179/Glukagon_benzeri_peptit_1in_ya%C4%9F_doku_kaynakl%C4%B1_mezenkimal_k%C3%B6k_h%C3%BCcrelerinin_kardiyomiyositlere_d%C3%B6n%C3%BC%C5%9Fmesi_%C3%BCzerindeki_etkisi"><img alt="Research paper thumbnail of Glukagon benzeri peptit-1'in yağ doku kaynaklı mezenkimal kök hücrelerinin kardiyomiyositlere dönüşmesi üzerindeki etkisi" class="work-thumbnail" src="https://attachments.academia-assets.com/115951707/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960179/Glukagon_benzeri_peptit_1in_ya%C4%9F_doku_kaynakl%C4%B1_mezenkimal_k%C3%B6k_h%C3%BCcrelerinin_kardiyomiyositlere_d%C3%B6n%C3%BC%C5%9Fmesi_%C3%BCzerindeki_etkisi">Glukagon benzeri peptit-1'in yağ doku kaynaklı mezenkimal kök hücrelerinin kardiyomiyositlere dönüşmesi üzerindeki etkisi</a></div><div class="wp-workCard_item"><span>Ege Tıp Dergisi</span><span>, Dec 12, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: Mesenchymal stem cells can easily differentiate into cardiomyocytes in vitro conditions usin...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: Mesenchymal stem cells can easily differentiate into cardiomyocytes in vitro conditions using various protocols. However, the agents used in these protocols have been reported to have some adverse effects on cell viability. Azacitidine is used to differentiate mesenchymal stem cells into cardiac muscle cells. The aim of the present study was to investigate the effects of Exenatide a GLP-1 receptor agonist, on differentiation and viability of human adipose tissue derived stem cells into cardiomyocytes. Materials and Methods: The effects of Azacytidine and Exenatide on cell viability and proliferation of human adipose tissue derived stem cells were analyzed with cytotoxicity assay. For differentiation procedure, of human adipose tissue derived stem cells were incubated with Azacytidine and Exenatide through four weeks. The morphological alterations of human adipose tissue derived stem cells were monitored and the expressions of cardiomyogenic differentiation markers (cTnI, GATA4 ve MYH7) were evaluated immunohistochemically. Also, cardiac troponin I (cTnI) levels in the cultures were measured using enzyme-linked immunosorbent assay. Results were evaluated by one way analysis of variance (ANOVA) and post-hoc test. Results: Treatment of the human adipose tissue derived stem cells with Azacytidine significantly decreased cell viability (54.4%) compared to control whereas treatment of cells with Azacytidine + Exenatide prevented cell death in a dose-dependent manner. Cells treated with Azacytidine and Exenatide showed significant morphological alterations consistent with cardiyomyogenic differentiation, and increase in expression cardiomyogenic markers. cTnI levels were found significantly higher in cultures treated separately and together with Azacytidine and Exenatide compared to control. Conclusion: Overall, these findings suggested that GLP-1 receptor agonist Exenatide may have beneficial effects on cardiomyogenic differention of human adipose tissue derived stem cells by reducing cell damage caused by Azacytidine.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="452353df55e61c1741db8c8bd325ad3e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951707,"asset_id":120960179,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951707/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960179"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960179"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960179; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960179]").text(description); $(".js-view-count[data-work-id=120960179]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960179; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960179']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "452353df55e61c1741db8c8bd325ad3e" } } $('.js-work-strip[data-work-id=120960179]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960179,"title":"Glukagon benzeri peptit-1'in yağ doku kaynaklı mezenkimal kök hücrelerinin kardiyomiyositlere dönüşmesi üzerindeki etkisi","translated_title":"","metadata":{"grobid_abstract":"Aim: Mesenchymal stem cells can easily differentiate into cardiomyocytes in vitro conditions using various protocols. However, the agents used in these protocols have been reported to have some adverse effects on cell viability. Azacitidine is used to differentiate mesenchymal stem cells into cardiac muscle cells. The aim of the present study was to investigate the effects of Exenatide a GLP-1 receptor agonist, on differentiation and viability of human adipose tissue derived stem cells into cardiomyocytes. Materials and Methods: The effects of Azacytidine and Exenatide on cell viability and proliferation of human adipose tissue derived stem cells were analyzed with cytotoxicity assay. For differentiation procedure, of human adipose tissue derived stem cells were incubated with Azacytidine and Exenatide through four weeks. The morphological alterations of human adipose tissue derived stem cells were monitored and the expressions of cardiomyogenic differentiation markers (cTnI, GATA4 ve MYH7) were evaluated immunohistochemically. Also, cardiac troponin I (cTnI) levels in the cultures were measured using enzyme-linked immunosorbent assay. Results were evaluated by one way analysis of variance (ANOVA) and post-hoc test. Results: Treatment of the human adipose tissue derived stem cells with Azacytidine significantly decreased cell viability (54.4%) compared to control whereas treatment of cells with Azacytidine + Exenatide prevented cell death in a dose-dependent manner. Cells treated with Azacytidine and Exenatide showed significant morphological alterations consistent with cardiyomyogenic differentiation, and increase in expression cardiomyogenic markers. cTnI levels were found significantly higher in cultures treated separately and together with Azacytidine and Exenatide compared to control. 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However, the agents used in these protocols have been reported to have some adverse effects on cell viability. Azacitidine is used to differentiate mesenchymal stem cells into cardiac muscle cells. The aim of the present study was to investigate the effects of Exenatide a GLP-1 receptor agonist, on differentiation and viability of human adipose tissue derived stem cells into cardiomyocytes. Materials and Methods: The effects of Azacytidine and Exenatide on cell viability and proliferation of human adipose tissue derived stem cells were analyzed with cytotoxicity assay. For differentiation procedure, of human adipose tissue derived stem cells were incubated with Azacytidine and Exenatide through four weeks. The morphological alterations of human adipose tissue derived stem cells were monitored and the expressions of cardiomyogenic differentiation markers (cTnI, GATA4 ve MYH7) were evaluated immunohistochemically. Also, cardiac troponin I (cTnI) levels in the cultures were measured using enzyme-linked immunosorbent assay. Results were evaluated by one way analysis of variance (ANOVA) and post-hoc test. Results: Treatment of the human adipose tissue derived stem cells with Azacytidine significantly decreased cell viability (54.4%) compared to control whereas treatment of cells with Azacytidine + Exenatide prevented cell death in a dose-dependent manner. Cells treated with Azacytidine and Exenatide showed significant morphological alterations consistent with cardiyomyogenic differentiation, and increase in expression cardiomyogenic markers. cTnI levels were found significantly higher in cultures treated separately and together with Azacytidine and Exenatide compared to control. Conclusion: Overall, these findings suggested that GLP-1 receptor agonist Exenatide may have beneficial effects on cardiomyogenic differention of human adipose tissue derived stem cells by reducing cell damage caused by Azacytidine.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951707,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951707/thumbnails/1.jpg","file_name":"2673316.pdf","download_url":"https://www.academia.edu/attachments/115951707/download_file","bulk_download_file_name":"Glukagon_benzeri_peptit_1in_yag_doku_kay.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951707/2673316-libre.pdf?1718278712=\u0026response-content-disposition=attachment%3B+filename%3DGlukagon_benzeri_peptit_1in_yag_doku_kay.pdf\u0026Expires=1743662386\u0026Signature=bsD0Y8qWMJDkYOCk5TLEc7nFSJKpk3G-OLvP9RQmqwcbMIII-jA4q~uS202z8lYZgxJHsc0DEpwK9lY72fnoEfn4XQeMsMCVJ3LyB-po9f5eZuv-KcUfEW~a~LiTVKROgVx5zzOIZ4P~5ks5xgwBUm4-xVGOVgwFewx3SJgiI8a38iUlPT85ImUnO9Dfk5TZn7Q6sDXVfxJ8A9heNwICN2R76Uh~Oyi~~1F0-Yq5OZeIHHksNferm2mtqLd8MSkKqB9mbTtJedxfX~a3f8xvAD36E34TJcYxDzE7vfHKtQQ3Y6o9IMwDmnEOZbEgovgjJFseQqZDjGDnVodVljZStg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951708,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951708/thumbnails/1.jpg","file_name":"2673316.pdf","download_url":"https://www.academia.edu/attachments/115951708/download_file","bulk_download_file_name":"Glukagon_benzeri_peptit_1in_yag_doku_kay.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951708/2673316-libre.pdf?1718278702=\u0026response-content-disposition=attachment%3B+filename%3DGlukagon_benzeri_peptit_1in_yag_doku_kay.pdf\u0026Expires=1743662386\u0026Signature=Th38zIiixxU29SF28S2rIWIWQXqg960W9N3GA2OWZIyAwieZfvF50F~8F6PVV8ic0NseKWrHZbAyxeHvBUZv~B72Mmyskqyb9mT1BFJadaiqPMvufiTegsR3LunY17GxAyk4cFknUSdyWb5NUOJvqXU16sfnBf4dBP6VugsWMTNWSHWOGedxmo~XAYxKks1SaudRMEwexqZpnI-frnlj-QuK7QclFEas1yV3jAmyM7vUB5zwowQbuN6fQm3NQX2qBhE1PRO0MscAXeb7-2WP~AStfT9ZRvnnkWdjELMDue1sur~EiFD0-Lh-gPGkMrlcN0IHyVdhwgNJYLt2mPkrwA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology"},{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":162972,"name":"Mesenchymal Stem Cell","url":"https://www.academia.edu/Documents/in/Mesenchymal_Stem_Cell"},{"id":216943,"name":"CD","url":"https://www.academia.edu/Documents/in/CD"},{"id":1335152,"name":"Viability assay","url":"https://www.academia.edu/Documents/in/Viability_assay"}],"urls":[{"id":42903035,"url":"http://egetipdergisi.com.tr/en/download/article-file/2673316"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960179-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960178"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960178/Adipose_Tissue_Mesenchymal_Stem_Cells_Exposed_To_Oxytocin_and_Sunitinib_are_Synergistically_Dystrophic"><img alt="Research paper thumbnail of Adipose Tissue Mesenchymal Stem Cells Exposed To Oxytocin and Sunitinib are Synergistically Dystrophic" class="work-thumbnail" src="https://attachments.academia-assets.com/115951704/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960178/Adipose_Tissue_Mesenchymal_Stem_Cells_Exposed_To_Oxytocin_and_Sunitinib_are_Synergistically_Dystrophic">Adipose Tissue Mesenchymal Stem Cells Exposed To Oxytocin and Sunitinib are Synergistically Dystrophic</a></div><div class="wp-workCard_item"><span>Dicle Medical Journal</span><span>, Sep 2, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after or...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after organ and tissue transplantation, in addition to their current wide range of uses and research areas. Sunitinib is a receptor tyrosine kinase with immunosuppressive properties and its cytotoxic activity in different types of cells is known. Our study aimed to elucidate the effect of oxytocin on sunitinib-treated MSCs. Methods: For this purpose, commercially available rat adipose tissue-derived MSC (ADMSCs) was used. The individual or combinational effect of the active substances on viability was evaluated with WST-1, the effect on apoptosis Annexin V, the effect on oxidative stress markers MDA, CAT, GPX, and SOD ELISA tests. Results: The IC50 value of sunitinib was determined as 44.57 µM at the 48th hour, and it was determined that oxytocin had no cytotoxic effect in doses up to 100 µM. Treatment of the two agents in combination increased the cytotoxic effect of sunitinib. Oxytocin attenuated the effect of sunitinib on apoptosis and lipid peroxidation. Conclusion: It is important to investigate the efficacy of these two substances individually and in combination with ADMSCs with further experiments to evaluate the potential use of oxytocin in organ and tissue transplantations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="67211c48673b667592660437db5c9a84" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951704,"asset_id":120960178,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951704/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960178"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960178"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960178; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960178]").text(description); $(".js-view-count[data-work-id=120960178]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960178; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960178']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "67211c48673b667592660437db5c9a84" } } $('.js-work-strip[data-work-id=120960178]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960178,"title":"Adipose Tissue Mesenchymal Stem Cells Exposed To Oxytocin and Sunitinib are Synergistically Dystrophic","translated_title":"","metadata":{"publisher":"Dicle University Medical School","ai_title_tag":"Oxytocin and Sunitinib Affect Stem Cell Viability","grobid_abstract":"Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after organ and tissue transplantation, in addition to their current wide range of uses and research areas. Sunitinib is a receptor tyrosine kinase with immunosuppressive properties and its cytotoxic activity in different types of cells is known. Our study aimed to elucidate the effect of oxytocin on sunitinib-treated MSCs. Methods: For this purpose, commercially available rat adipose tissue-derived MSC (ADMSCs) was used. The individual or combinational effect of the active substances on viability was evaluated with WST-1, the effect on apoptosis Annexin V, the effect on oxidative stress markers MDA, CAT, GPX, and SOD ELISA tests. Results: The IC50 value of sunitinib was determined as 44.57 µM at the 48th hour, and it was determined that oxytocin had no cytotoxic effect in doses up to 100 µM. Treatment of the two agents in combination increased the cytotoxic effect of sunitinib. Oxytocin attenuated the effect of sunitinib on apoptosis and lipid peroxidation. Conclusion: It is important to investigate the efficacy of these two substances individually and in combination with ADMSCs with further experiments to evaluate the potential use of oxytocin in organ and tissue transplantations.","publication_date":{"day":2,"month":9,"year":2022,"errors":{}},"publication_name":"Dicle Medical Journal","grobid_abstract_attachment_id":115951704},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960178/Adipose_Tissue_Mesenchymal_Stem_Cells_Exposed_To_Oxytocin_and_Sunitinib_are_Synergistically_Dystrophic","translated_internal_url":"","created_at":"2024-06-13T04:02:25.097-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951704,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951704/thumbnails/1.jpg","file_name":"2628657.pdf","download_url":"https://www.academia.edu/attachments/115951704/download_file","bulk_download_file_name":"Adipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951704/2628657-libre.pdf?1718278715=\u0026response-content-disposition=attachment%3B+filename%3DAdipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf\u0026Expires=1743662386\u0026Signature=bzglZ~9MFGEue2FtMj0bsuy8nnQrMgND6PE-GPSvnSgPpeJZU~cVo343CdyE8JLkQ5Ip7RsPWHAmdvRfexPZ9kfGfZxz1dDn~G1~NLCUmcO5nzpb24SIeqdVdrVsLq2KpafTAU8eHaOon7-VlKEq2eiUfvgfFZcki6B5iEHfzijjIzl2W36JmIdpmim5VRuKTySCG6RGwySQ5b2zaMjV8~l6URJhT1QFJxUgfRarD1ynNdTjqi~G890DHf~ufWUP7~mx4hbAoIBk60p1WvF1QRzt~wCZXKh4w4EEMYGLHHt3MwhNKUIF32~hAH8Bf6~LqYOcZ8ga21mnBOu-yM5PuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Adipose_Tissue_Mesenchymal_Stem_Cells_Exposed_To_Oxytocin_and_Sunitinib_are_Synergistically_Dystrophic","translated_slug":"","page_count":8,"language":"en","content_type":"Work","summary":"Objective: Mesenchymal stem cells (MSCs) are also promising in immunosuppressed patients after organ and tissue transplantation, in addition to their current wide range of uses and research areas. Sunitinib is a receptor tyrosine kinase with immunosuppressive properties and its cytotoxic activity in different types of cells is known. Our study aimed to elucidate the effect of oxytocin on sunitinib-treated MSCs. Methods: For this purpose, commercially available rat adipose tissue-derived MSC (ADMSCs) was used. The individual or combinational effect of the active substances on viability was evaluated with WST-1, the effect on apoptosis Annexin V, the effect on oxidative stress markers MDA, CAT, GPX, and SOD ELISA tests. Results: The IC50 value of sunitinib was determined as 44.57 µM at the 48th hour, and it was determined that oxytocin had no cytotoxic effect in doses up to 100 µM. Treatment of the two agents in combination increased the cytotoxic effect of sunitinib. Oxytocin attenuated the effect of sunitinib on apoptosis and lipid peroxidation. Conclusion: It is important to investigate the efficacy of these two substances individually and in combination with ADMSCs with further experiments to evaluate the potential use of oxytocin in organ and tissue transplantations.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951704,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951704/thumbnails/1.jpg","file_name":"2628657.pdf","download_url":"https://www.academia.edu/attachments/115951704/download_file","bulk_download_file_name":"Adipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951704/2628657-libre.pdf?1718278715=\u0026response-content-disposition=attachment%3B+filename%3DAdipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf\u0026Expires=1743662386\u0026Signature=bzglZ~9MFGEue2FtMj0bsuy8nnQrMgND6PE-GPSvnSgPpeJZU~cVo343CdyE8JLkQ5Ip7RsPWHAmdvRfexPZ9kfGfZxz1dDn~G1~NLCUmcO5nzpb24SIeqdVdrVsLq2KpafTAU8eHaOon7-VlKEq2eiUfvgfFZcki6B5iEHfzijjIzl2W36JmIdpmim5VRuKTySCG6RGwySQ5b2zaMjV8~l6URJhT1QFJxUgfRarD1ynNdTjqi~G890DHf~ufWUP7~mx4hbAoIBk60p1WvF1QRzt~wCZXKh4w4EEMYGLHHt3MwhNKUIF32~hAH8Bf6~LqYOcZ8ga21mnBOu-yM5PuA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951705,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951705/thumbnails/1.jpg","file_name":"2628657.pdf","download_url":"https://www.academia.edu/attachments/115951705/download_file","bulk_download_file_name":"Adipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951705/2628657-libre.pdf?1718278713=\u0026response-content-disposition=attachment%3B+filename%3DAdipose_Tissue_Mesenchymal_Stem_Cells_Ex.pdf\u0026Expires=1743662386\u0026Signature=SovaLZLqM-A9F~OaJg9SWwvZNhYOqvYvuIFvLpQywcJNDSPHFTDtdCh-Idna7hwM2c-wOgWWvmLTjLB504MuMYcpB~ni-lqUy6ogEbSJmKCLsOHqLVRQLdzvty~twimCPkTRKdP2G1Dt-NiFowt2UxjuAdkaB13BR2THJQVywVm6jPbTRX5wotbUijSFTEIFpC9gM4HSbWfpHbcpqtPavm24uasVPIU9wLR37D0-mqWXygvr0IDEgLgUqu8chwjuJXTRLRn2lf3YzKKu7JU6hqfHoeQpRqS14UVnBTl6~kZ6em3VcyQCDyQ0zizeFlqOmtLQNrqHu1cF0K1DWYXuJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":52489,"name":"Adipose tissue","url":"https://www.academia.edu/Documents/in/Adipose_tissue"},{"id":162972,"name":"Mesenchymal Stem Cell","url":"https://www.academia.edu/Documents/in/Mesenchymal_Stem_Cell"},{"id":233372,"name":"Lipid peroxidation","url":"https://www.academia.edu/Documents/in/Lipid_peroxidation"},{"id":1213146,"name":"Sunitinib","url":"https://www.academia.edu/Documents/in/Sunitinib"}],"urls":[{"id":42903034,"url":"https://dergipark.org.tr/en/download/article-file/2628657"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960178-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960177"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960177/Rejeneratif_t%C4%B1pta_model_organizma_Aksolotl_Ambystoma_Mexicanum_"><img alt="Research paper thumbnail of Rejeneratif tıpta model organizma; Aksolotl (Ambystoma Mexicanum)" class="work-thumbnail" src="https://attachments.academia-assets.com/115951703/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960177/Rejeneratif_t%C4%B1pta_model_organizma_Aksolotl_Ambystoma_Mexicanum_">Rejeneratif tıpta model organizma; Aksolotl (Ambystoma Mexicanum)</a></div><div class="wp-workCard_item"><span>Ege Tıp Dergisi</span><span>, Mar 15, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The axolotl has an extraordinary capacity to regenerate damaged and lost structures, especially t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The axolotl has an extraordinary capacity to regenerate damaged and lost structures, especially the nervous system, limbs, organs such as the eye and heart, without causing scarring. It has become a very important model organism by attracting the attention of scientists working in both developmental biology and regenerative medicine and stem cell biology. The axolotl, which is amphibian and tetrapod, is a more preferred model due to its ease of maintenance and reproduction compared to other organisms such as African clawed frog (Xenopus laevis) or zebrafish (Danio rerio), which are relatively difficult to study. The main purposes of this review are the definition and origin of the axolotl, its taxonomy, anatomy, reproduction, nutrition, habitat, to give a perspective to scientists who want to work on this model organism by giving examples to the scientific data and study fields of the last 20 years by addressing issues such as how it contributes to scientific studies as a model organism.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c9b969440e39ac1703a94e5786768d3a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951703,"asset_id":120960177,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951703/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960177"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960177"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960177; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960177]").text(description); $(".js-view-count[data-work-id=120960177]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960177; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960177']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c9b969440e39ac1703a94e5786768d3a" } } $('.js-work-strip[data-work-id=120960177]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960177,"title":"Rejeneratif tıpta model organizma; Aksolotl (Ambystoma Mexicanum)","translated_title":"","metadata":{"ai_title_tag":"Axolotl as a Model Organism in Regenerative Medicine","grobid_abstract":"The axolotl has an extraordinary capacity to regenerate damaged and lost structures, especially the nervous system, limbs, organs such as the eye and heart, without causing scarring. 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Yöntemler: Çalışmamızda, %10'luk formaldehit ile tespit edilmiş, makroskobik patolojisi gözlenmeyen, doku bütünlüğü bozulmamış yetişkin kadavra beyin hemisferleri arasından elde edilen dokular kullanıldı. Beş kadavra beyninden alınan örneklerden üçü uygun boyama metoduna ulaşabilmek amacıyla kullanıldı. Doku fiksasyon metodu, Hematoksilen-eozin boyama metodu ve Luxol fast blue boyama metodu uygulandı. Bulgular: Histolojik olarak ilk defa corpus callosum (CC), indusium griseum (IG) ve stria longitudinalis (SL) aynı görüntü üzerinde tespit edildi. SL'in lifleri, vasküler ve morfolojik yapısı belirtildi. Sonuç: Umuyoruz ki, SL ile ilgili histolojik, immünohistokimyasal ve anatomik yaklaşımlar ışığında yaptığımız bu girişim, bu konu üzerindeki bazı karanlık yönleri aydınlatacaktır. Böylece bizden sonra SL üzerinde çalışacak araştırmacıların istifadesine sunulmak üzere akademik bir hafıza oluşturacaktır.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c25fbe33ee95eada9905940f12d6f91f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951702,"asset_id":120960176,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951702/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960176"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960176"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960176; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960176]").text(description); $(".js-view-count[data-work-id=120960176]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960176; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960176']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c25fbe33ee95eada9905940f12d6f91f" } } $('.js-work-strip[data-work-id=120960176]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960176,"title":"Stria longitudinalis medialis ve lateralis’in morfolojik olarak incelenmesi","translated_title":"","metadata":{"publisher":"Dicle University Medical School","grobid_abstract":"Amaç: Bu çalışmada, bilinen bazı boyama yöntemlerinin modifiye edilerek stria longitudinalis medialis ve lateralis'in histo-morfolojik olarak incelenmesi ve elde edilecek bulguların bundan sonra yapılacak olan benzer çalışmalara ışık tutması amaçlanmıştır. Yöntemler: Çalışmamızda, %10'luk formaldehit ile tespit edilmiş, makroskobik patolojisi gözlenmeyen, doku bütünlüğü bozulmamış yetişkin kadavra beyin hemisferleri arasından elde edilen dokular kullanıldı. Beş kadavra beyninden alınan örneklerden üçü uygun boyama metoduna ulaşabilmek amacıyla kullanıldı. Doku fiksasyon metodu, Hematoksilen-eozin boyama metodu ve Luxol fast blue boyama metodu uygulandı. Bulgular: Histolojik olarak ilk defa corpus callosum (CC), indusium griseum (IG) ve stria longitudinalis (SL) aynı görüntü üzerinde tespit edildi. SL'in lifleri, vasküler ve morfolojik yapısı belirtildi. Sonuç: Umuyoruz ki, SL ile ilgili histolojik, immünohistokimyasal ve anatomik yaklaşımlar ışığında yaptığımız bu girişim, bu konu üzerindeki bazı karanlık yönleri aydınlatacaktır. Böylece bizden sonra SL üzerinde çalışacak araştırmacıların istifadesine sunulmak üzere akademik bir hafıza oluşturacaktır.","publication_date":{"day":15,"month":12,"year":2019,"errors":{}},"publication_name":"Dicle Medical Journal","grobid_abstract_attachment_id":115951701},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960176/Stria_longitudinalis_medialis_ve_lateralis_in_morfolojik_olarak_incelenmesi","translated_internal_url":"","created_at":"2024-06-13T04:02:23.632-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951702,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951702/thumbnails/1.jpg","file_name":"891316.pdf","download_url":"https://www.academia.edu/attachments/115951702/download_file","bulk_download_file_name":"Stria_longitudinalis_medialis_ve_lateral.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951702/891316-libre.pdf?1718278718=\u0026response-content-disposition=attachment%3B+filename%3DStria_longitudinalis_medialis_ve_lateral.pdf\u0026Expires=1743662386\u0026Signature=VG6Ohs3uO6BbICMFT~YfufhWL7-LtHS1Zxpz2QitLjVRE18jjPm~x9iK5X4Cxqll5qJWf9YeQHv5BQOTHwhtz0Kex7C9ERtqRkmkA0wFb7VM48yWMUyS3od8-j1ksEO3HSfx17tnqQvTV25UrnkcswfBA4jZhqQZT03-SV4VyLWD8bQO2qc7wM5xWHK~skzqUO02WrzCWq-CJgVPFAPzZ6pYUg28AVChrqrieCGuz8J939KeG1hd4SJsTGfuD~HwbpmiXXi9DvHoX3Oexy10dveeriXZWwDpS0iaJQFj2kkYqKUfg2sky3Bw4tA-EpiX5B07lVKqI~BbpH89DrJSCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Stria_longitudinalis_medialis_ve_lateralis_in_morfolojik_olarak_incelenmesi","translated_slug":"","page_count":10,"language":"tr","content_type":"Work","summary":"Amaç: Bu çalışmada, bilinen bazı boyama yöntemlerinin modifiye edilerek stria longitudinalis medialis ve lateralis'in histo-morfolojik olarak incelenmesi ve elde edilecek bulguların bundan sonra yapılacak olan benzer çalışmalara ışık tutması amaçlanmıştır. Yöntemler: Çalışmamızda, %10'luk formaldehit ile tespit edilmiş, makroskobik patolojisi gözlenmeyen, doku bütünlüğü bozulmamış yetişkin kadavra beyin hemisferleri arasından elde edilen dokular kullanıldı. Beş kadavra beyninden alınan örneklerden üçü uygun boyama metoduna ulaşabilmek amacıyla kullanıldı. Doku fiksasyon metodu, Hematoksilen-eozin boyama metodu ve Luxol fast blue boyama metodu uygulandı. Bulgular: Histolojik olarak ilk defa corpus callosum (CC), indusium griseum (IG) ve stria longitudinalis (SL) aynı görüntü üzerinde tespit edildi. SL'in lifleri, vasküler ve morfolojik yapısı belirtildi. Sonuç: Umuyoruz ki, SL ile ilgili histolojik, immünohistokimyasal ve anatomik yaklaşımlar ışığında yaptığımız bu girişim, bu konu üzerindeki bazı karanlık yönleri aydınlatacaktır. Böylece bizden sonra SL üzerinde çalışacak araştırmacıların istifadesine sunulmak üzere akademik bir hafıza oluşturacaktır.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951702,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951702/thumbnails/1.jpg","file_name":"891316.pdf","download_url":"https://www.academia.edu/attachments/115951702/download_file","bulk_download_file_name":"Stria_longitudinalis_medialis_ve_lateral.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951702/891316-libre.pdf?1718278718=\u0026response-content-disposition=attachment%3B+filename%3DStria_longitudinalis_medialis_ve_lateral.pdf\u0026Expires=1743662386\u0026Signature=VG6Ohs3uO6BbICMFT~YfufhWL7-LtHS1Zxpz2QitLjVRE18jjPm~x9iK5X4Cxqll5qJWf9YeQHv5BQOTHwhtz0Kex7C9ERtqRkmkA0wFb7VM48yWMUyS3od8-j1ksEO3HSfx17tnqQvTV25UrnkcswfBA4jZhqQZT03-SV4VyLWD8bQO2qc7wM5xWHK~skzqUO02WrzCWq-CJgVPFAPzZ6pYUg28AVChrqrieCGuz8J939KeG1hd4SJsTGfuD~HwbpmiXXi9DvHoX3Oexy10dveeriXZWwDpS0iaJQFj2kkYqKUfg2sky3Bw4tA-EpiX5B07lVKqI~BbpH89DrJSCw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951701,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951701/thumbnails/1.jpg","file_name":"891316.pdf","download_url":"https://www.academia.edu/attachments/115951701/download_file","bulk_download_file_name":"Stria_longitudinalis_medialis_ve_lateral.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951701/891316-libre.pdf?1718278721=\u0026response-content-disposition=attachment%3B+filename%3DStria_longitudinalis_medialis_ve_lateral.pdf\u0026Expires=1743662386\u0026Signature=YGpc5KfFyVKLd5jCquCyX62OqZ~vdKl5vQ2C-WB9EwhLdUyxILnL2hSHHzGyEGNa-YqP7ZSMG-7HRWlzsc-A1fdNc~woKFX90hiPT6FcGFTESf8E0WQzSs9BHggz9TK68~82FRlJyP8ijmj-gyJ2EujiVIm7YMAzy45OmnV-edLu-wO8tFBPIV6GpjibsAtSaIH-vMqTZhHrn5kKLqefiSKCU~DWS0QyqpLMw6Jf6qG-74-6zzD-Dm~y46jpAYOyAQ~tQ42l-NsZER4zlVpyuLOG~sEpDnbUhGOcx4-H2DfDyR8DVW9fkoJro3K4XpylQIDFuwlYZBvS1vzBO-I3Rg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[{"id":42903032,"url":"https://dergipark.org.tr/tr/download/article-file/891316"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960176-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960175"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960175/Microscopy_Investigation_of_the_Immune_System_Cells_of_Hirudo_Medicinalis_Linnaeus_1758"><img alt="Research paper thumbnail of Microscopy Investigation of the Immune System Cells of Hirudo Medicinalis Linnaeus, 1758" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Microscopy Investigation of the Immune System Cells of Hirudo Medicinalis Linnaeus, 1758</div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinali...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinalis. Four hemocytes types were identified; prohemocytes, plasmatocytes, granulocytes and eleocytes. They were characterized by light microscopy according to size, presence or absence of granules and nucleus/cytoplasm ratio. The prohemocytes were the smallest cells with large nuclei in the hemolymph. Plasmatocytes were polymorphic, varied from ovoid to spindle-shaped cells. Plasmatocytes were the most abundant hemocyte type in the hemolymph of H. medicinalis. Granulocytes were elliptical in shape and characterized by the presence of cytoplasmic granules. Eleocytes were spherical cells with homogeneous and slightly granular cytoplasm. The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960175"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960175"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960175; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960175]").text(description); $(".js-view-count[data-work-id=120960175]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960175; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960175']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960175]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960175,"title":"Microscopy Investigation of the Immune System Cells of Hirudo Medicinalis Linnaeus, 1758","translated_title":"","metadata":{"abstract":"The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinalis. Four hemocytes types were identified; prohemocytes, plasmatocytes, granulocytes and eleocytes. They were characterized by light microscopy according to size, presence or absence of granules and nucleus/cytoplasm ratio. The prohemocytes were the smallest cells with large nuclei in the hemolymph. Plasmatocytes were polymorphic, varied from ovoid to spindle-shaped cells. Plasmatocytes were the most abundant hemocyte type in the hemolymph of H. medicinalis. Granulocytes were elliptical in shape and characterized by the presence of cytoplasmic granules. Eleocytes were spherical cells with homogeneous and slightly granular cytoplasm. The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical","publication_date":{"day":null,"month":null,"year":2017,"errors":{}}},"translated_abstract":"The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinalis. Four hemocytes types were identified; prohemocytes, plasmatocytes, granulocytes and eleocytes. They were characterized by light microscopy according to size, presence or absence of granules and nucleus/cytoplasm ratio. The prohemocytes were the smallest cells with large nuclei in the hemolymph. Plasmatocytes were polymorphic, varied from ovoid to spindle-shaped cells. Plasmatocytes were the most abundant hemocyte type in the hemolymph of H. medicinalis. Granulocytes were elliptical in shape and characterized by the presence of cytoplasmic granules. Eleocytes were spherical cells with homogeneous and slightly granular cytoplasm. The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical","internal_url":"https://www.academia.edu/120960175/Microscopy_Investigation_of_the_Immune_System_Cells_of_Hirudo_Medicinalis_Linnaeus_1758","translated_internal_url":"","created_at":"2024-06-13T04:02:23.107-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Microscopy_Investigation_of_the_Immune_System_Cells_of_Hirudo_Medicinalis_Linnaeus_1758","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The present study was carried out to determine hemocyte types of medical leech, Hirudo medicinalis. Four hemocytes types were identified; prohemocytes, plasmatocytes, granulocytes and eleocytes. They were characterized by light microscopy according to size, presence or absence of granules and nucleus/cytoplasm ratio. The prohemocytes were the smallest cells with large nuclei in the hemolymph. Plasmatocytes were polymorphic, varied from ovoid to spindle-shaped cells. Plasmatocytes were the most abundant hemocyte type in the hemolymph of H. medicinalis. Granulocytes were elliptical in shape and characterized by the presence of cytoplasmic granules. Eleocytes were spherical cells with homogeneous and slightly granular cytoplasm. The aim of this study was to characterise the hemocytes in H. medicinalis and to determine whether any differences from other invertebrates in terms of hemocyte types due to use in medical","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":955941,"name":"Hirudo Medicinalis","url":"https://www.academia.edu/Documents/in/Hirudo_Medicinalis"}],"urls":[{"id":42903031,"url":"https://avesis.ege.edu.tr/yayin/816059e5-a614-4104-a6a2-ddd9b7308111/microscopy-investigation-of-the-immune-system-cells-of-hirudo-medicinalis-linnaeus-1758"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960175-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960174"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960174/Review_paper_Neural_stem_cell_therapy_in_neurological_diseases"><img alt="Research paper thumbnail of Review paper Neural stem cell therapy in neurological diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/115951700/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960174/Review_paper_Neural_stem_cell_therapy_in_neurological_diseases">Review paper Neural stem cell therapy in neurological diseases</a></div><div class="wp-workCard_item"><span>Archives of Medical Science</span><span>, Oct 22, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Early developmental process of mammalian embryo is almost completely directed by the behavior of ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural stem cells has brought novel approaches as to the use of stem cells in the treatment of some neurodegenerative disorders such as Parkinson, Alzheimer disease and amyotrophic lateral sclerosis, as well as in the management of spinal cord injuries. However, scientific literature requires detailed information regarding the proliferation and differentiation of stem cells and the mechanisms controlling the migration of these cells to the targeted central nervous system site. Development of new therapeutic protocols using stem cells and their effective clinical application in the future would bring light to cope with a number of systemic diseases, especially neurological disorders. This review has considered the biological features of stem cells, stem cell plasticity, potential application of stem cells in neurological diseases and cancer, highlighting the promises as well as the problems of this treatment approach.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ac9aadbe2ab157fc2f35cd99a5461eb9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951700,"asset_id":120960174,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951700/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960174"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960174"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960174; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960174]").text(description); $(".js-view-count[data-work-id=120960174]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960174; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960174']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ac9aadbe2ab157fc2f35cd99a5461eb9" } } $('.js-work-strip[data-work-id=120960174]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960174,"title":"Review paper Neural stem cell therapy in neurological diseases","translated_title":"","metadata":{"publisher":"Termedia Publishing House","grobid_abstract":"Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural stem cells has brought novel approaches as to the use of stem cells in the treatment of some neurodegenerative disorders such as Parkinson, Alzheimer disease and amyotrophic lateral sclerosis, as well as in the management of spinal cord injuries. However, scientific literature requires detailed information regarding the proliferation and differentiation of stem cells and the mechanisms controlling the migration of these cells to the targeted central nervous system site. Development of new therapeutic protocols using stem cells and their effective clinical application in the future would bring light to cope with a number of systemic diseases, especially neurological disorders. This review has considered the biological features of stem cells, stem cell plasticity, potential application of stem cells in neurological diseases and cancer, highlighting the promises as well as the problems of this treatment approach.","publication_date":{"day":22,"month":10,"year":2009,"errors":{}},"publication_name":"Archives of Medical Science","grobid_abstract_attachment_id":115951700},"translated_abstract":null,"internal_url":"https://www.academia.edu/120960174/Review_paper_Neural_stem_cell_therapy_in_neurological_diseases","translated_internal_url":"","created_at":"2024-06-13T04:02:22.836-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951700/thumbnails/1.jpg","file_name":"pdf-13453-1.pdf","download_url":"https://www.academia.edu/attachments/115951700/download_file","bulk_download_file_name":"Review_paper_Neural_stem_cell_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951700/pdf-13453-1-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DReview_paper_Neural_stem_cell_therapy_in.pdf\u0026Expires=1743662386\u0026Signature=fS5~KBX5ZSUbEGDMLCMKdJQSqS0vBtEmLdijnrZHxhp-t3nYFUD2x9YQsdrpCTI2GSz2A85RLTashnVOWdhB952lpFTZcyDQNpXe5gCdqGkwL~a5sd2IZmvqSJmUA1nTSI79kKs60kLQdDRfbg6HLDsCukwNA21eqcw-6ykVRtJJ5IxAesKy3DTk2MVL8zW5ScExw3XJLhpWY35TW3VzpkNDoDpC-FOXRqbU8y-g0IN6aR36gW1BzHkleKb8rrF0zEURTa0H84TOa-wz1mVgNohLv68Uedgxi9Sd~fD2Ee8adFUPhi-N9nM-D2lmz1Rq85mq58RKFovOXypyaIe5aA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Review_paper_Neural_stem_cell_therapy_in_neurological_diseases","translated_slug":"","page_count":7,"language":"en","content_type":"Work","summary":"Early developmental process of mammalian embryo is almost completely directed by the behavior of stem cells, which is controlled by both environmental and intrinsic factors. These cells commonly subject to dividing, migration, deterioration or death. Comparing to all other tissues in the body, central nervous system has a considerably limited capacity to regenerate. Recent knowledge on neural stem cells has brought novel approaches as to the use of stem cells in the treatment of some neurodegenerative disorders such as Parkinson, Alzheimer disease and amyotrophic lateral sclerosis, as well as in the management of spinal cord injuries. However, scientific literature requires detailed information regarding the proliferation and differentiation of stem cells and the mechanisms controlling the migration of these cells to the targeted central nervous system site. Development of new therapeutic protocols using stem cells and their effective clinical application in the future would bring light to cope with a number of systemic diseases, especially neurological disorders. This review has considered the biological features of stem cells, stem cell plasticity, potential application of stem cells in neurological diseases and cancer, highlighting the promises as well as the problems of this treatment approach.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[{"id":115951700,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951700/thumbnails/1.jpg","file_name":"pdf-13453-1.pdf","download_url":"https://www.academia.edu/attachments/115951700/download_file","bulk_download_file_name":"Review_paper_Neural_stem_cell_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951700/pdf-13453-1-libre.pdf?1718278703=\u0026response-content-disposition=attachment%3B+filename%3DReview_paper_Neural_stem_cell_therapy_in.pdf\u0026Expires=1743662386\u0026Signature=fS5~KBX5ZSUbEGDMLCMKdJQSqS0vBtEmLdijnrZHxhp-t3nYFUD2x9YQsdrpCTI2GSz2A85RLTashnVOWdhB952lpFTZcyDQNpXe5gCdqGkwL~a5sd2IZmvqSJmUA1nTSI79kKs60kLQdDRfbg6HLDsCukwNA21eqcw-6ykVRtJJ5IxAesKy3DTk2MVL8zW5ScExw3XJLhpWY35TW3VzpkNDoDpC-FOXRqbU8y-g0IN6aR36gW1BzHkleKb8rrF0zEURTa0H84TOa-wz1mVgNohLv68Uedgxi9Sd~fD2Ee8adFUPhi-N9nM-D2lmz1Rq85mq58RKFovOXypyaIe5aA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":115951699,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951699/thumbnails/1.jpg","file_name":"pdf-13453-1.pdf","download_url":"https://www.academia.edu/attachments/115951699/download_file","bulk_download_file_name":"Review_paper_Neural_stem_cell_therapy_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951699/pdf-13453-1-libre.pdf?1718278700=\u0026response-content-disposition=attachment%3B+filename%3DReview_paper_Neural_stem_cell_therapy_in.pdf\u0026Expires=1743662386\u0026Signature=eemLQ-lFn~B8kPlpkPSqnGQDwMFA9lYxyfIkSPZ~qZChMd6CBM6gQmed6GWnZTrqPRTnmR0yMPcNLQmgXnA0ClEP9ow4sS1usTu50Djx0odoVpjrkag5YLK7jP0dBjoOiyQWE-EtS7syIWGC29NYUh-H7e0PJJhmBtT1qUgns5KAdEBxPLTQtk0u4OVBoUrG57XZCDxDnTFNESWq3k8YMa1sUbliN5QcEFp7B6t0cg1dHLh5JgLcfdEGRCKawy0CQ81pcATmef5JGcxcN8joRbYS4nPiPmDj6O8ip085UAkkWcMT~yjJP52OS1-UdkgTdRjckpM-4ELaLN9ijMnHjw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37853,"name":"Stem cell Therapy","url":"https://www.academia.edu/Documents/in/Stem_cell_Therapy"},{"id":57148,"name":"Neural stem cell","url":"https://www.academia.edu/Documents/in/Neural_stem_cell"}],"urls":[{"id":42903030,"url":"https://www.termedia.pl/Journal/-19/pdf-13453-1?filename=Neural%20stem.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960174-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960173"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960173/Histological_and_Immunological_Evaluation_of_the_Osteogenic_Effects_of_Compact_Bone_Delivered_Stem_Cell_on_Spongiosis_Bone_in_the_Rat_Zygomatic_Arch_Defect_Model"><img alt="Research paper thumbnail of Histological and Immunological Evaluation of the Osteogenic Effects of Compact Bone-Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">Histological and Immunological Evaluation of the Osteogenic Effects of Compact Bone-Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model</div><div class="wp-workCard_item"><span>PubMed</span><span>, Sep 1, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P > 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P < 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P < 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P > 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P < 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P > 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960173]").text(description); $(".js-view-count[data-work-id=120960173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960173,"title":"Histological and Immunological Evaluation of the Osteogenic Effects of Compact Bone-Delivered Stem Cell on Spongiosis Bone in the Rat Zygomatic Arch Defect Model","translated_title":"","metadata":{"abstract":"Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P \u003e 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P \u003c 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P \u003c 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P \u003e 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P \u003c 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P \u003e 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.","publication_date":{"day":1,"month":9,"year":2023,"errors":{}},"publication_name":"PubMed"},"translated_abstract":"Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P \u003e 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P \u003c 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P \u003c 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P \u003e 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P \u003c 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P \u003e 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.","internal_url":"https://www.academia.edu/120960173/Histological_and_Immunological_Evaluation_of_the_Osteogenic_Effects_of_Compact_Bone_Delivered_Stem_Cell_on_Spongiosis_Bone_in_the_Rat_Zygomatic_Arch_Defect_Model","translated_internal_url":"","created_at":"2024-06-13T04:02:22.617-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Histological_and_Immunological_Evaluation_of_the_Osteogenic_Effects_of_Compact_Bone_Delivered_Stem_Cell_on_Spongiosis_Bone_in_the_Rat_Zygomatic_Arch_Defect_Model","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Background: In stem cell applications, apart from bone marrow and adipose tissue, compact bone is also used as an alternative. However, studies on this subject are limited. In our study, we investigated the effect of stem cell derived from compact bone on rat zygomatic arch defect. Methods: Fifteen rats were included in the study. Five rats were killed to obtain stem cells before the experiment. The rats were divided into 2 groups with 5 rats each. In group 1, compact bone-derived stem cell was applied. In group 2, adipose tissue-derived stem cell was applied. Right zygomatic arch defect was created in rats in both groups. Zygomatic bones were decellularized by cryosurgery. Stem cells were transferred to zygomatic bones. The number of stem cells, stem cell differentiation, and superficial markers obtained from the groups were examined. Histologically, cell structure, osteocyte count and osteopontin scores, elemental composition of the groups, percentages of resemblance to intact bone, osteocytes numbers, and cells were examined by electron microscopy of the bones in the groups after killing. Results: The number of stem cells administered to the groups was 5 × 107 and 3.2 × 107 for group 1 and group 2, respectively (P \u003e 0.05). Histologically, the morphology of the cells in group 1 was found to be healthier than group 2. The number of osteocytes was 97.56 ± 15.4 and 132.93 ± 10.8 in group 1 and group 2, respectively (P \u003c 0.05). The osteopontin score was 3.47 ± 0.73 and 65 ± 0.64 in group 1 and group 2, respectively (P \u003c 0.05). In the electron microscope examination, the morphologies of the cells in group 1 were seen more normal. The Ca/P ratio of the groups was 1.51 and 1.59 in group 1 and group 2, respectively (P \u003e 0.05). Osteocyte counts were 10.7 ± 2.8 and 6.1 ± 1.2 in group 1 and group 2, respectively (P \u003c 0.05). Morphological similarity percentages to normal bone were 88.4% and 79.6% in group 1 and group 2, respectively (P \u003e 0.05). Conclusion: Stem cells obtained from compact bone gave positive results in zygomatic arch defect. This method can also be used as an alternative in stem cell applications.","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[],"research_interests":[{"id":23163,"name":"Stem Cell","url":"https://www.academia.edu/Documents/in/Stem_Cell"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":190152,"name":"Osteocyte","url":"https://www.academia.edu/Documents/in/Osteocyte"},{"id":203376,"name":"Osteopontin","url":"https://www.academia.edu/Documents/in/Osteopontin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":2929995,"name":"zygomatic bone","url":"https://www.academia.edu/Documents/in/zygomatic_bone"}],"urls":[{"id":42903029,"url":"https://pubmed.ncbi.nlm.nih.gov/37566821"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960173-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/120960172/_sup_99m_sup_Tc_Technetium_Labeled_Niosomes_Radiolabeling_Quality_Control_and_i_In_Vitro_i_Evaluation"><img alt="Research paper thumbnail of [<sup>99m</sup>Tc]Technetium-Labeled Niosomes: Radiolabeling, Quality Control, and <i>In Vitro</i> Evaluation" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title">[<sup>99m</sup>Tc]Technetium-Labeled Niosomes: Radiolabeling, Quality Control, and <i>In Vitro</i> Evaluation</div><div class="wp-workCard_item"><span>ACS omega</span><span>, Feb 8, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960172; 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CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960168"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960168"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960168; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960168]").text(description); $(".js-view-count[data-work-id=120960168]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960168; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960168']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=120960168]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960168,"title":"The protective effect of exogen melatonin upon fetal hippocampus damage caused by high-dose caffeine administration in pregnant rats","translated_title":"","metadata":{"abstract":"Objective: Caffeine (CAF), which is in the methylxanthines group (1,3,7-trimethylxanthine), is a neurologically active food component that is widely consumed and has a stimulating effect on the central nervous system. CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...","publisher":"Research Square Platform LLC"},"translated_abstract":"Objective: Caffeine (CAF), which is in the methylxanthines group (1,3,7-trimethylxanthine), is a neurologically active food component that is widely consumed and has a stimulating effect on the central nervous system. CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...","internal_url":"https://www.academia.edu/120960168/The_protective_effect_of_exogen_melatonin_upon_fetal_hippocampus_damage_caused_by_high_dose_caffeine_administration_in_pregnant_rats","translated_internal_url":"","created_at":"2024-06-13T04:02:21.651-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_protective_effect_of_exogen_melatonin_upon_fetal_hippocampus_damage_caused_by_high_dose_caffeine_administration_in_pregnant_rats","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Objective: Caffeine (CAF), which is in the methylxanthines group (1,3,7-trimethylxanthine), is a neurologically active food component that is widely consumed and has a stimulating effect on the central nervous system. CAF taken in high doses during pregnancy rapidly crosses the placenta and causes many negative conditions such as low birth weight infants, premature births, spontaneous abortion, stillbirth, and principally fetal growth retardation. On the other hand, melatonin (MEL) is an endogenous hormone secreted from the pineal gland that plays a role in the regulation of many biological functions such as sleep, biological rhythm, reproduction, immunity and has neuroprotective effects. In this study, we aimed to investigate the possible effects of exogenous MEL on the fetal hippocampus damage caused by high-dose CAF administration in pregnant rats. Methods: In the study, 32 adult Wistar albino female rats were divided into four experimental groups after conception (n=8). No compo...","owner":{"id":61194091,"first_name":"Yigit","middle_initials":null,"last_name":"UYANIKGIL","page_name":"YigitUYANIKGIL","domain_name":"ege","created_at":"2017-03-08T05:19:53.692-08:00","display_name":"Yigit UYANIKGIL","url":"https://ege.academia.edu/YigitUYANIKGIL"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51570,"name":"Melatonin","url":"https://www.academia.edu/Documents/in/Melatonin"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":67129,"name":"Caffeine","url":"https://www.academia.edu/Documents/in/Caffeine"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":181597,"name":"Root-Mean Square Error","url":"https://www.academia.edu/Documents/in/Root-Mean_Square_Error"},{"id":613283,"name":"Pineal Gland","url":"https://www.academia.edu/Documents/in/Pineal_Gland"},{"id":770944,"name":"Fetus","url":"https://www.academia.edu/Documents/in/Fetus"},{"id":4151399,"name":"Root mean square error","url":"https://www.academia.edu/Documents/in/Root_mean_square_error"}],"urls":[{"id":42903025,"url":"https://www.researchsquare.com/article/rs-2709866/v1"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") if (false) { Aedu.setUpFigureCarousel('profile-work-120960167-figures'); } }); </script> <div class="js-work-strip profile--work_container" data-work-id="120960166"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/120960166/The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats"><img alt="Research paper thumbnail of The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats" class="work-thumbnail" src="https://attachments.academia-assets.com/115951746/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/120960166/The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats">The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats</a></div><div class="wp-workCard_item"><span>Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DN...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 μg/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. It was concluded that PS may trigger dysregulation...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b9ae7076148249cbe3b9a0f73484a412" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":115951746,"asset_id":120960166,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/115951746/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="120960166"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="120960166"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 120960166; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=120960166]").text(description); $(".js-view-count[data-work-id=120960166]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 120960166; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='120960166']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b9ae7076148249cbe3b9a0f73484a412" } } $('.js-work-strip[data-work-id=120960166]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":120960166,"title":"The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 μg/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. 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We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. It was concluded that PS may trigger dysregulation...","internal_url":"https://www.academia.edu/120960166/The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats","translated_internal_url":"","created_at":"2024-06-13T04:02:21.304-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":61194091,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":115951746,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/115951746/thumbnails/1.jpg","file_name":"2469932.pdf","download_url":"https://www.academia.edu/attachments/115951746/download_file","bulk_download_file_name":"The_Effects_of_Prenatal_Stress_on_Cortic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/115951746/2469932-libre.pdf?1718278699=\u0026response-content-disposition=attachment%3B+filename%3DThe_Effects_of_Prenatal_Stress_on_Cortic.pdf\u0026Expires=1743662387\u0026Signature=CAiUu4BZRyDxiKssYZvDYS0aMLbS5eaZlExafwUKe8ckIUJfzrKh8u5SYOhIcvR7WTJtQSFjzoFthgSq5LKCZShq67oNvTzgtu7MfZCkRIdpVbhOVj92yDpl9r09i5opfmBgRDGAjpv79QdL~aZckPlo-1XiL5CC4Xw7y3-J5vw4rSVTwQRYZVbvHZ-ANbZnSjtb3l39sAEQh5hv-qca8rwrnqv-zMBZtGbJoLQuHk2t6nTRZRdUTjX2KEq477yJzoTeOoSsGnVhtJNjvjIHjL02FJu7NnJUO4NdnWIqwmXpR2MM1tz67bVtCPUY4P5TpcbibvxQ34uw2taT~nDghQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"The_Effects_of_Prenatal_Stress_on_Cortical_and_Hippocampal_Gene_Expression_Profiles_of_DNA_Methyltransferases_and_Histone_Deacetylases_in_Female_Rats","translated_slug":"","page_count":13,"language":"en","content_type":"Work","summary":"The aim of this study was to investigate the effects of prenatal stress (PS) on mRNA levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in cerebral cortex and hippocampus of female rats. PS was induced in rats with dexamethasone (Dex). From gestation day 14 to 21, pregnant rats were injected daily with Dex (100 μg/kg) or saline. After birth, at 3 months of age, female rats were decapitated (n=5). The effects of Dex on epigenetic mechanisms were investigated by real-time PCR through mRNA levels of DNMT1, DNMT3a, DNMT3b, HDAC1 and HDAC2. Statistical significant differences were determined with one-way analysis of variance. Prenatal Dex exposure caused significant increases in DNMT3a, HDAC1 and HDAC2 mRNA levels in cortex and hippocampus. We further found that DNMT3b mRNA levels significantly increased in hippocampus but decreased in cortex of Dex group. No significant differences were found in DNMT1 mRNA levels. 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