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An expert-driven guide to pharmacological targets with quantitative information on the prescription medicines and experimental drugs that act on them. 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width:220px; float:left; margin-right:7px;"> <h4>Ligand Activity Charts</h4> <div class="contentbox"> <p style="text-align:center;margin-bottom:5px;"> <a href="/GRAC/ligandActivityDisplay.jsp" target="_blank" onClick="recordEvent(this, 'Home Page', 'Ligand Activity Charts', 'Ligand Activity Charts image');return false;"><img src="images/ligact_thumb3.png" width="170" alt="GtoPdb Ligand Activity Charts"/></a></p> <p style="margin-bottom:5px; line-height: 1.6;">Use our <b>interactive ligand activity charts</b> to compare pharmacology across targets and species.</p> </div></div>  <div class="backandborder middle" style="height:240px; width:220px; float:left; margin-right:10px;margin-left:7px;margin-bottom: 10px;"> <h4>Natural Products in GtoPdb</h4> <p style="line-height: 1.6;font-size:larger;margin: 3px 0px 3px 0px;"><a href="/GRAC/NaturalProductsForward" target="_blank"><b>Expert-driven curation of Natural Products</b></a></p> <div style="float:left;padding: 10px 5px 0px 5px;"><a href="https://www.sifweb.org/" target="_blank"><img src="images/logo-sif-vert.svg" width="75" alt="Societa Italiana Di Farmacologia Logo"/></a></div> <p style="margin: 1px 0px 5px 0px;">IUPHAR and the Italian Society of Pharmacology (SIF) are collaborating to provide an expert-driven project to curate NPs as a resource within the GtoPdb</p> <div style="text-align:center ;padding: 0px 5px 0px 5px;"><a href="https://iuphar.org/" target="_blank"><img src="images/IUPHAR_new.png" width="115" alt="IUPHAR Logo"/></a></div> </div> <div class="immuno_backandborder gtip_guide" style="border-width: 2px; 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width:220px; float:left; margin-left:8px;"> <h4>The Concise Guide to PHARMACOLOGY 2023/24</h4> <div class="contentbox" > <p style="text-align:center;margin-bottom:5px;"> <a href="https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2', 'CGTP table of contents');return false;"><img src="images/CGTP_cover2324.png" alt="Concise Guide to Pharmacology 2023/24" width="170px" height="126px"/></a></p> <p style="margin-bottom:5px;"><strong><a href="https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2', 'CGTP table of contents');return false;">Access the table of contents</a></strong> <a href="https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2', 'CGTP table of contents');return false;"><img src="images_dev27082012/go.jpg"></a></p> <p style="margin-bottom:5px;">Please see the 5 minute introductory video on the Concise Guide:</p> <div id="social_media_cookies2" class="cc-cookies-error" style="font-size:90%;">Sorry, this content is unavailable until you click to accept cookies from this site.<br/><a class="cc-cookie-accept" style="color:white;" href="#accept">ACCEPT COOKIES</a></div> <div id="cgtp_youtube" style="display:none;"> <p id style="margin-bottom:5px;"><iframe width="200" src="https://www.youtube.com/embed/TCsR30TqiN4" frameborder="0" allowfullscreen encrypted-media onClick="recordEvent(this, 'Concise Guide video', 'https://www.youtube.com/embed/uMTgqeWG_K0', 'Concise Guide Video');return false;"></iframe></p> </div> <script> if (jQuery.cookie('cc_cookie_accept') == "cc_cookie_accept") { $('#social_media_cookies2').hide(); //do_twitter_widget(document,'script','twitter-wjs'); $('#cgtp_youtube').show(); } </script> </div> </div> </div> <div class="backandborder grid_16 pub_guide" style="background-color: white;"> <h4>Recent Publications </h4> <div class="content_box"> <div class="grid_2 alpha" style="background-color: white; text-align:center; vertical-align: middle;"> <p style="text-align:center;"><img src="images_dev27082012/bjp_thumb.jpg" width="100" height="132" alt="BJP journal cover"/></p> </div> <div class="grid_6" style="background-color: white;"> <h3 style="text-align:left;"><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17379" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17379', 'BJP IUPHAR Review 41');return false;">Insight into structural properties of viral G protein-coupled receptors and their role in the viral infection: IUPHAR Review 41</a></h3> <p style="text-align:left;">Tsutsumi N, Kildedal DF, Hansen OK, Kong Q, Schols D, Van Loy T, Rosenkilde MM. (2024) <i>Br J Pharmacol.</i> EPub ahead of print. 10.1111/bph.17379. <a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17379" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17379', 'BJP IUPHAR Review 41');return false;"><img src="images_dev27082012/go.jpg" alt="go icon to follow link"></a></p> <h3 style="text-align:left;"><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17308" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17308', 'BJP IUPHAR Review 40');return false;">Targeting RNA with small molecules, from RNA structures to precision medicines: IUPHAR review: 40</a></h3> <p style="text-align:left;">Tong Y, Childs-Disney JL, Disney MD. (2024) <i>Br J Pharmacol.</i> EPub ahead of print. doi: 10.1111/bph.17308. <a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17308" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17308', 'BJP IUPHAR Review 40');return false;"><img src="images_dev27082012/go.jpg" alt="go icon to follow link"></a></p> <h3 style="text-align:left;"><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17317" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17317', 'BJP IUPHAR Review X');return false;">Advancing the field of viroporins-Structure, function and pharmacology: IUPHAR Review 39</a></h3> <p style="text-align:left;">Devantier K, Kj忙r VMS, Griffin S, Kragelund BB, Rosenkilde MM. (2024) <i>Br J Pharmacol.</i> EPub ahead of print. 10.1111/bph.17317. <a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17317" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17317', 'BJP IUPHAR Review 39');return false;"><img src="images_dev27082012/go.jpg" alt="go icon to follow link"></a></p> </div> <div class="grid_2" style="background-color: white; text-align:center; vertical-align: middle;"> <p style="text-align:center;"><img src="images_dev27082012/PharmRev_thumb_lg.jpg" width="100" height="132" alt="Pharm Rev journal cover"/></p> </div> <div class="grid_6 omega" style="background-color: white;"> <h3 style="text-align:left;"><a href="https://pharmrev.aspetjournals.org/content/early/2024/10/07/pharmrev.124.001361" target="_blank" onClick="recordEvent(this, 'Pharm Rev links', 'https://pharmrev.aspetjournals.org/content/early/2024/10/07/pharmrev.124.001361', 'Pharm Rev IUPHAR Review CXVIII');return false;">International Union of Basic and Clinical Pharmacology. CXVIII. Update on the Nomenclature for Atypical Chemokine Receptors including ACKR5</a></h3> <p style="text-align:left;">Chevign茅 A, Legler DF, Rot A, Sozzani S, Szpakowska M, Thelen M (2024) <i>Pharmacol Rev.</i> PHARMREV-INR-2024-001361. doi: <a href="https://doi.org/10.1124/pharmrev.124.001361" target="_blank">10.1124/pharmrev.124.001361</a>. <a href="https://pharmrev.aspetjournals.org/content/early/2024/10/07/pharmrev.124.001361" target="_blank" onClick="recordEvent(this, 'Pharm Rev links', 'https://pharmrev.aspetjournals.org/content/early/2024/10/07/pharmrev.124.001361', 'Pharm Rev IUPHAR Review CXVIII');return false;"><img src="images_dev27082012/go.jpg" alt="go icon to follow link"></a></p> <h3 style="text-align:left;"><a href="https://pharmrev.aspetjournals.org/content/early/2024/08/30/pharmrev.123.001140" target="_blank" onClick="recordEvent(this, 'Pharm Rev links', 'https://pharmrev.aspetjournals.org/content/early/2024/08/30/pharmrev.123.001140', 'Pharm Rev IUPHAR Review CXVII');return false;">International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors: Structures, functions, activators and blockers</a></h3> <p style="text-align:left;">Behrens M (2024) <i>Pharmacol Rev.</i> PHARMREV-INR-2023-001140. doi: <a href="https://doi.org/10.1124/pharmrev.123.001140" target="_blank">10.1124/pharmrev.123.001140</a>. <a href="https://pharmrev.aspetjournals.org/content/early/2024/08/30/pharmrev.123.001140" target="_blank" onClick="recordEvent(this, 'Pharm Rev links', 'https://pharmrev.aspetjournals.org/content/early/2024/08/30/pharmrev.123.001140', 'Pharm Rev IUPHAR Review CXVII');return false;"><img src="images_dev27082012/go.jpg" alt="go icon to follow link"></a></p> <h3 style="text-align:left;"><a href="https://pharmrev.aspetjournals.org/content/76/5/622" target="_blank" onClick="recordEvent(this, 'Pharm Rev links', 'https://pharmrev.aspetjournals.org/content/76/5/622', 'Pharm Rev IUPHAR Review CXVI');return false;">International Union of Basic and Clinical Pharmacology CXVI: NC-IUPHAR and Pharmacological Reviews: 30+ Years of Collaboration鈥擡ditorial</a></h3> <p style="text-align:left;">Ohlstein EH (2024) <i>Pharmacol Rev.</i> 76(5):622-624. doi: <a href="https://doi.org/10.1124/pharmrev.124.001409" target="_blank">10.1124/pharmrev.124.001409</a>. <a href="https://pharmrev.aspetjournals.org/content/76/5/622" target="_blank" onClick="recordEvent(this, 'Pharm Rev links', 'https://pharmrev.aspetjournals.org/content/76/5/622', 'Pharm Rev IUPHAR Review CXVI');return false;"><img src="images_dev27082012/go.jpg" alt="go icon to follow link"></a></p> </div> <div class="grid_4 prefix_12" style="background-color: white; margin-left:0px;"> <p class="contentboxpara" style="text-align: right;margin-top: 0px;"><a href="/nciupharPublications.jsp">Publication list <img src="images_dev27082012/go.jpg" alt="go icon to follow link"></a></p> </div> </div> </div> <div class="backandborder grid_16" style="background-color: white;"> <h4><a href="#dataset">Celebrating >20 years of Servier support</h4> <p style="text-align: center;"><a href="https://www.servier.com" target="_blank"><img src="images/servier.jpg" style="width:200px"></a></p> <div class="grid_14 prefix_1 suffix_1" style="margin:0px;"> <p style="text-align: center; padding: 5px;"><a href="https://www.servier.com" target="_blank">Servier</a>, a mid-size French Pharmaceutical company, has a long history in pharmacology, and has supported <a href="/nciuphar.jsp">NC-IUPHAR</a> for >20 years with unrestricted educational grants which have permitted the Paris meetings and thus progress of the database.</p> </div> </div> <div class="clear"></div> <div id="footer"> <div> <div style="display:table-cell; 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