Alzheimer Disease | Psychiatrist.com

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data-sizes="(max-width: 640px) 100vw, 640px" class="aligncenter wp-image-39542 size-large lazyload" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" /><noscript><img decoding="async" class="aligncenter wp-image-39542 size-large" src="https://www.psychiatrist.com/wp-content/uploads/2021/12/1200x600-Alzheimer-1024x512.png" alt="" width="640" height="320" srcset="https://www.psychiatrist.com/wp-content/uploads/2021/12/1200x600-Alzheimer-1024x512.png 1024w, https://www.psychiatrist.com/wp-content/uploads/2021/12/1200x600-Alzheimer-300x150.png 300w, https://www.psychiatrist.com/wp-content/uploads/2021/12/1200x600-Alzheimer-768x384.png 768w, https://www.psychiatrist.com/wp-content/uploads/2021/12/1200x600-Alzheimer.png 1200w" sizes="(max-width: 640px) 100vw, 640px" /></noscript></p> </div> <div class="c-blog-list">  <div class="row"> <div class="col-12 col-md-6 c-blog-list-single">  <div class="c-blog-list-post blue"> <div class="post-cat-title"> <span class="box-icon"></span> <h7> <span style="cursor: pointer;" aria-label="Go to page"> ORIGINAL RESEARCH </span> </h7> </div> <div class="c-blog-list-post-cont" role="contentinfo"> <div class="row align-item-center"> <div class="col-12"> <h2> <a href="https://www.psychiatrist.com/pcc/brain-atrophy-first-episode-psychosis-elderly-associated-cognitive-decline/" aria-label="Go to page">Brain Atrophy, Cognitive Decline, and First-Episode Psychosis</a> </h2> <h3>The etiology of first-episode psychosis (FEP) in the elderly is unknown, but an underlying neurodegenerative disorder may be an important factor. To investigate further, this study assessed brain atrophy and cognitive decline in elderly patients with FEP.</h3> <h3><em>Prim Care Companion CNS Disord 2021;23(6):20m02865</em></h3> </div> </div> </div> <div class="c-blog-list-post-info"> <h9>Ulla-Marja Louhija and others</h9> <span class="duration">FREE</span> </div> </div>  </div> <div class="col-12 col-md-6 c-blog-list-single">  <div class="c-blog-list-post red"> <div class="post-cat-title"> <span class="box-icon"></span> <h7> <span style="cursor: pointer;" aria-label="Go to page"> ORIGINAL RESEARCH </span> </h7> </div> <div class="c-blog-list-post-cont" role="contentinfo"> <div class="row align-item-center"> <div class="col-12"> <h2> <a href="https://www.psychiatrist.com/jcp/association-of-alopecia-areata-and-the-risk-of-dementia-nationwide-cohort-study/" aria-label="Go to page">Alopecia Areata and Dementia</a> </h2> <h3>Alopecia areata (AA) shares a similar inflammatory signature with dementia, and AA’s negative psychosocial impact may lead to poor social engagement, a risk factor for dementia. This nationwide cohort study explored the link between AA and dementia risk.</h3> <h3><em>J Clin Psychiatry 2021;82(6):21m13931</em></h3> </div> </div> </div> <div class="c-blog-list-post-info"> <h9>Cheng-Yuan Li and others</h9> </div> </div>  </div> <div class="col-12 col-md-6 c-blog-list-single">  <div class="c-blog-list-post red"> <div class="post-cat-title"> <span class="box-icon"></span> <h7> <span style="cursor: pointer;" aria-label="Go to page"> ORIGINAL RESEARCH </span> </h7> </div> <div class="c-blog-list-post-cont" role="contentinfo"> <div class="row align-item-center"> <div class="col-12"> <h2> <a href="https://www.psychiatrist.com/jcp/polygenic-effects-lipid-metabolic-pathway-accelerated-pathological-changes-disrupted-default-mode-network-trajectory-across-alzheimer-disease-spectrum/" aria-label="Go to page">Lipid-Related Polygenic Effects Across the AD Spectrum</a> </h2> <h3>Lipid-related genes and serum lipids may affect cognitive function via regulating brain networks. This study investigated polygenic effects of the lipid metabolic pathway on cerebrospinal fluid core biomarkers, cognition, and the default mode network.</h3> <h3><em>J Clin Psychiatry 2021;82(6):20m13739</em></h3> </div> </div> </div> <div class="c-blog-list-post-info"> <h9>Feifei Zang and others</h9> </div> </div>  </div> <div class="col-12 col-md-6 c-blog-list-single">  <div class="c-blog-list-post red"> <div class="post-cat-title"> <span class="box-icon"></span> <h7> <span style="cursor: pointer;" aria-label="Go to page"> ORIGINAL RESEARCH </span> </h7> </div> <div class="c-blog-list-post-cont" role="contentinfo"> <div class="row align-item-center"> <div class="col-12"> <h2> <a href="https://www.psychiatrist.com/jcp/amyloid-burden-depressive-symptom-trajectories-older-adults-at-risk-of-cognitive-decline/" aria-label="Go to page">Amyloid Load and Depression in Older Adults</a> </h2> <h3>Amyloid load can impact cognitive decline in older adults, but does it affect depressive symptoms, and if so, which ones? This 3-year study provides some answers.</h3> <h3><em>J Clin Psychiatry 2021;82(5):20m13410</em></h3> </div> </div> </div> <div class="c-blog-list-post-info"> <h9>Ismael Conejero and others</h9> </div> </div>  </div> <div class="col-12 col-md-6 c-blog-list-single">  <div class="c-blog-list-post red"> <div class="post-cat-title"> <span class="box-icon"></span> <h7> <span style="cursor: pointer;" aria-label="Go to page"> FREE CME: ACADEMIC HIGHLIGHTS </span> </h7> </div> <div class="c-blog-list-post-cont" role="contentinfo"> <div class="row align-item-center"> <div class="col-12"> <h2> <a href="https://www.psychiatrist.com/jcp/treatment-challenges-in-early-stage-ad/" aria-label="Go to page">Treatment Challenges in Early-Stage AD</a> </h2> <h3>Experts offer an overview of best practices for managing early-stage Alzheimer disease as well as a look at the future.</h3> <h3><em>J Clin Psychiatry 2021;82(4):BG20044AH4C</em></h3> </div> </div> </div> <div class="c-blog-list-post-info"> <h9>Anna D. Burke and others</h9> <span class="duration">FREE</span> </div> </div>  </div> <div class="col-12 col-md-6 c-blog-list-single">  <div class="c-blog-list-post red"> <div class="post-cat-title"> <span class="box-icon"></span> <h7> <span style="cursor: pointer;" aria-label="Go to page"> FREE CME: WEBCAST </span> </h7> </div> <div class="c-blog-list-post-cont" role="contentinfo"> <div class="row align-item-center"> <div class="col-12"> <h2> <a href="https://www.psychiatrist.com/jcp/can-emerging-therapies-resolve-unmet-needs-current-treatment-early-stage-ad/" aria-label="Go to page">Pharmacotherapies for Early-Stage Alzheimer Disease</a> </h2> <h3>How do investigational drugs for Alzheimer disease differ from those currently prescribed to patients? Dr Burke shares her insights.</h3> <h3><em>J Clin Psychiatry 2021;82(3):BG20044WC3C</em></h3> </div> </div> </div> <div class="c-blog-list-post-info"> <h9>Anna D. Burke</h9> <span class="duration">FREE</span> </div> </div>  </div> <div class="col-12 col-md-6 c-blog-list-single">  <div class="c-blog-list-post red"> <div class="post-cat-title"> <span class="box-icon"></span> <h7> <span style="cursor: pointer;" aria-label="Go to page"> FREE CME: WEBCAST </span> </h7> </div> <div class="c-blog-list-post-cont" role="contentinfo"> <div class="row align-item-center"> <div class="col-12"> <h2> <a href="https://www.psychiatrist.com/jcp/talking-patients-and-care-partners-about-treatment-goals-and-challenges-early-stage-ad/" aria-label="Go to page">Discussing Early-Stage AD With Patients</a> </h2> <h3>In this webcast about early-stage Alzheimer disease, Drs Burke and Apostolova highlight important conversations to have with patients and their care partners on topics such as diet, exercise, driving, and plans for the later stage of illness.</h3> <h3><em>J Clin Psychiatry. 2021;82(3):BG20044WC2C</em></h3> </div> </div> </div> <div class="c-blog-list-post-info"> <h9>Anna D. 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Editor: Dr Andrade’s analysis of the Bacloville trial in a recent Clinical and Practical Psychopharmacology column, in which he concluded that “individualized treatment with high-dose baclofen (30-300 mg/d) may be a useful second-line approach in heavy drinkers” and that “baclofen may be particularly useful in patients with liver disease,” deserves comment.1 First, Andrade failed to recall that the first pivotal trial of baclofen, ALPADIR (NCT01738282; 320 patients, as with Bacloville), was negative (see Braillon et al2). Second, Dr Andrade should have warned readers that Bacloville’s results are most questionable, lacking robustness. Although he cited us,3 he overlooked the evidence we provided indicating that the Bacloville article4 was published without acknowledging major changes to the initial protocol, affecting the primary outcome. Coincidentally (although as skeptics, we do not believe in coincidence), the initial statistical team was changed when data were sold to the French pharmaceutical company applying for the marketing authorization in France. As Ronald H. 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