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</div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"><span class="mw-redirectedfrom">(Redirected from <a href="/w/index.php?title=Intra-articular_injection&redirect=no" class="mw-redirect" title="Intra-articular injection">Intra-articular injection</a>)</span></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Method of delivering drugs into a joint</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical intervention</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background-color: lightblue">Joint injection</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Hip_joint_injection_by_anterior_longitudinal_approach.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/Hip_joint_injection_by_anterior_longitudinal_approach.jpg/280px-Hip_joint_injection_by_anterior_longitudinal_approach.jpg" decoding="async" width="280" height="438" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/1/11/Hip_joint_injection_by_anterior_longitudinal_approach.jpg 1.5x" data-file-width="400" data-file-height="626" /></a></span><div class="infobox-caption"><a href="/wiki/Ultrasound-guided_hip_joint_injection" title="Ultrasound-guided hip joint injection">Ultrasound-guided hip joint injection</a>: A skin mark is made to mark the optimal point of entry for the needle.<sup id="cite_ref-YeapRobinson2017_1-0" class="reference"><a href="#cite_note-YeapRobinson2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></div></td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Orthopedics" class="mw-redirect" title="Orthopedics">Orthopedics</a></td></tr><tr class="noprint"><td colspan="2" class="infobox-full-data"><div style="text-align: right;">[<a href="https://www.wikidata.org/wiki/Q4833215" class="extiw" title="d:Q4833215">edit on Wikidata</a>]</div></td></tr></tbody></table> <p>In <a href="/wiki/Medicine" title="Medicine">medicine</a>, a <b>joint injection</b> (<b>intra-articular injection</b>) is a procedure used in the treatment of <a href="/wiki/Inflammation" title="Inflammation">inflammatory joint conditions</a>, such as <a href="/wiki/Rheumatoid_arthritis" title="Rheumatoid arthritis">rheumatoid arthritis</a>, <a href="/wiki/Psoriatic_arthritis" title="Psoriatic arthritis">psoriatic arthritis</a>, <a href="/wiki/Gout" title="Gout">gout</a>, <a href="/wiki/Tendinitis" class="mw-redirect" title="Tendinitis">tendinitis</a>, <a href="/wiki/Bursitis" title="Bursitis">bursitis</a>, <a href="/wiki/Carpal_Tunnel_Syndrome" class="mw-redirect" title="Carpal Tunnel Syndrome">Carpal Tunnel Syndrome</a>,<sup id="cite_ref-CarpalTunnelReview.com_2-0" class="reference"><a href="#cite_note-CarpalTunnelReview.com-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> and occasionally <a href="/wiki/Osteoarthritis" title="Osteoarthritis">osteoarthritis</a>.<sup id="cite_ref-freedict_3-0" class="reference"><a href="#cite_note-freedict-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Wen2000_4-0" class="reference"><a href="#cite_note-Wen2000-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> A hypodermic needle is injected into the affected <a href="/wiki/Joint" title="Joint">joint</a> where it delivers a dose of any one of many <a href="/wiki/Anti-inflammatory" title="Anti-inflammatory">anti-inflammatory</a> agents, the most common of which are <a href="/wiki/Corticosteroid" title="Corticosteroid">corticosteroids</a>. <a href="/wiki/Hyaluronic_acid" title="Hyaluronic acid">Hyaluronic acid</a>, because of its high <a href="/wiki/Viscosity" title="Viscosity">viscosity</a>, is sometimes used to replace <a href="/wiki/Bursa_(anatomy)" class="mw-redirect" title="Bursa (anatomy)">bursa</a> fluids.<sup id="cite_ref-Wen2000_4-1" class="reference"><a href="#cite_note-Wen2000-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> The technique may be used to also withdraw excess fluid from the joint.<sup id="cite_ref-freedict_3-1" class="reference"><a href="#cite_note-freedict-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Efficacy_in_osteoarthritis">Efficacy in osteoarthritis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Joint_injection&action=edit&section=1" title="Edit section: Efficacy in osteoarthritis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In <a href="/wiki/Osteoarthritis" title="Osteoarthritis">osteoarthritis</a>, joint injection of <a href="/wiki/Glucocorticoid" title="Glucocorticoid">glucocorticoids</a> (such as <a href="/wiki/Hydrocortisone" title="Hydrocortisone">hydrocortisone</a>) leads to short term pain relief that may last between a few weeks and a few months.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Injections of <a href="/wiki/Hyaluronic_acid" title="Hyaluronic acid">hyaluronic acid</a> have not produced improvement compared to placebo for knee arthritis,<sup id="cite_ref-Rutjes12_6-0" class="reference"><a href="#cite_note-Rutjes12-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> but did increase risk of further pain.<sup id="cite_ref-Rutjes12_6-1" class="reference"><a href="#cite_note-Rutjes12-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> In ankle osteoarthritis, evidence is unclear.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> The effectiveness of injections of <a href="/wiki/Platelet-rich_plasma" title="Platelet-rich plasma">platelet-rich plasma</a> is unclear; there are suggestions that such injections improve function but not pain, and are associated with increased risk.<sup class="noprint Inline-Template" style="margin-left:0.1em; white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Vagueness" title="Wikipedia:Vagueness"><span title="This information is too vague. (May 2015)">vague</span></a></i>]</sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>A 2015 Cochrane review found that intra-articular corticosteroid injections of the knee did not benefit quality of life and had no effect on knee joint space; clinical effects one to six weeks after injection could not be determined clearly due to poor study quality.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Another 2015 study reported negative effects of intra-articular corticosteroid injections at higher doses,<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> and a 2017 trial showed reduction in cartilage thickness with intra-articular <a href="/wiki/Triamcinolone" title="Triamcinolone">triamcinolone</a> every 12 weeks for 2 years compared to placebo.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> A 2018 study found that intra-articular triamcinolone is associated with an increase in <a href="/wiki/Intraocular_pressure" title="Intraocular pressure">intraocular pressure</a>.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Ultrasound-guided">Ultrasound-guided</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Joint_injection&action=edit&section=2" title="Edit section: Ultrasound-guided"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Usual standards for musculoskeletal interventional procedures apply include review of previous imaging, informed consent and appropriate local anesthetic. The use of a high-frequency (> 10 MHz) linear array transducer is recommended, but lower-frequency curvilinear probes may be occasionally required to visualize deep structures in larger patients. A preliminary diagnostic sonographic examination, including color Doppler of the area to be punctured is necessary to define the relationship of adjacent neurovascular structures.<sup id="cite_ref-YeapRobinson2017_1-1" class="reference"><a href="#cite_note-YeapRobinson2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>Injections should be performed with adherence to aseptic technique although this varies between institutions and radiologists attributable to resources, training, perceived risk and experience.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> In a survey of 250 health professionals in the United Kingdom, 43.5% believed infection rates were < 1/1000 following intra-articular injections, 33.0% perceived rates were < 1/100, and 2.6% perceived the risk as negligible.<sup id="cite_ref-YeapRobinson2017_1-2" class="reference"><a href="#cite_note-YeapRobinson2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Sterile preparation of the entire injection field, including adjacent skin where the gel and probe are applied, is recommended. Areas of superficial infection such as cellulitis or abscess should be avoided to prevent deeper spread.<sup id="cite_ref-YeapRobinson2017_1-3" class="reference"><a href="#cite_note-YeapRobinson2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>After planning a safe route of access, a line parallel to the long axis of the transducer is drawn on the skin adjacent to the end of transducer where the needle will be introduced. Once the patient's skin is sterilized and initial needle entry is made adjacent to the mark, the probe can be returned quickly to the same location and orientation by aligning to the skin mark. The needle is directed toward the intended target by a freehand technique. The needle size, length and type should be selected based on the site, depth and patient's body habitus. 22–24G needles are sufficed for most injections.<sup id="cite_ref-YeapRobinson2017_1-4" class="reference"><a href="#cite_note-YeapRobinson2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>As an example, <a href="/wiki/Ultrasound-guided_hip_joint_injection" title="Ultrasound-guided hip joint injection">ultrasound-guided hip joint injection</a><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> can be considered when symptoms persist despite initial treatment options such as activity modification, analgesia and physical therapy.<sup id="cite_ref-YeapRobinson2017_1-5" class="reference"><a href="#cite_note-YeapRobinson2017-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Joint_injection&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-YeapRobinson2017-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-YeapRobinson2017_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-YeapRobinson2017_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-YeapRobinson2017_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-YeapRobinson2017_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-YeapRobinson2017_1-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-YeapRobinson2017_1-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text">Initially largely copied from: <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFYeapRobinson2017" class="citation journal cs1">Yeap, Phey Ming; Robinson, Philip (2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251072">"Ultrasound Diagnostic and Therapeutic Injections of the Hip and Groin"</a>. <i>Journal of the Belgian Society of Radiology</i>. <b>101</b> (S2): 6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.5334%2Fjbr-btr.1371">10.5334/jbr-btr.1371</a></span>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/2514-8281">2514-8281</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251072">6251072</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30498802">30498802</a>.</cite><span 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href="#cite_ref-CarpalTunnelReview.com_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20130730124449/http://carpaltunnelreview.com/">"Carpal Tunnel Review"</a>. 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Retrieved <span class="nowrap">25 July</span> 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Carpal+Tunnel+Review&rft.pub=JohnDRhoads&rft.date=2013-07-25&rft_id=http%3A%2F%2Fwww.carpaltunnelreview.com&rfr_id=info%3Asid%2Fen.wikipedia.org%3AJoint+injection" class="Z3988"></span></span> </li> <li id="cite_note-freedict-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-freedict_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-freedict_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://medical-dictionary.thefreedictionary.com/intraarticular+injection">"intraarticular injection - definition"</a>. <i><a href="/wiki/TheFreeDictionary.com" class="mw-redirect" title="TheFreeDictionary.com">TheFreeDictionary.com</a></i>. 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Retrieved <span class="nowrap">2021-05-21</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=R3+Medical+Training&rft.atitle=MSK+Ultrasound+Guided+Injection&rft_id=https%3A%2F%2Fr3medicaltraining.com%2Fevents%2Fmsk-ultrasound-guided-injection-course%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AJoint+injection" class="Z3988"></span></span> </li> </ol></div></div> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol 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administration">Oral</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;white-space:normal;"><a href="/wiki/Human_gastrointestinal_tract" class="mw-redirect" title="Human gastrointestinal tract">Digestive tract</a> (<a href="/wiki/Enteral_administration" title="Enteral administration">enteral</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;white-space:normal;"><a href="/wiki/Solid" title="Solid">Solids</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tablet_(pharmacy)" title="Tablet (pharmacy)">Tablet</a></li> <li><a href="/wiki/Capsule_(pharmacy)" title="Capsule (pharmacy)">Capsule</a></li> <li><a href="/wiki/Pastille" title="Pastille">Pastille</a></li> <li><a href="/wiki/Time_release_technology" class="mw-redirect" title="Time release technology">Time release technology</a></li> <li><a href="/wiki/Osmotic-controlled_release_oral_delivery_system" title="Osmotic-controlled release oral delivery system">Osmotic delivery system</a></li></ul> </div></td><td class="noviewer navbox-image" rowspan="2" style="width:1px;padding:0 0 0 2px"><div><span typeof="mw:File"><a href="/wiki/File:FlattenedRoundPills.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/FlattenedRoundPills.jpg/60px-FlattenedRoundPills.jpg" decoding="async" width="60" height="45" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/FlattenedRoundPills.jpg/90px-FlattenedRoundPills.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/FlattenedRoundPills.jpg/120px-FlattenedRoundPills.jpg 2x" data-file-width="2048" data-file-height="1536" /></a></span><br /><span typeof="mw:File"><a href="/wiki/File:Hexaaquatitanium(III)-solution.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Hexaaquatitanium%28III%29-solution.jpg/60px-Hexaaquatitanium%28III%29-solution.jpg" decoding="async" width="60" height="67" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Hexaaquatitanium%28III%29-solution.jpg/90px-Hexaaquatitanium%28III%29-solution.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bf/Hexaaquatitanium%28III%29-solution.jpg/120px-Hexaaquatitanium%28III%29-solution.jpg 2x" data-file-width="1619" data-file-height="1816" /></a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;white-space:normal;"><a href="/wiki/Liquid" title="Liquid">Liquids</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Decoction" title="Decoction">Decoction</a></li> <li><a href="/wiki/Elixir" title="Elixir">Elixir</a></li> <li><a href="/wiki/Electuary" title="Electuary">Electuary</a></li> <li><a href="/wiki/Emulsion" title="Emulsion">Emulsion</a></li> <li><a href="/wiki/Effervescent_tablet" title="Effervescent tablet">Effervescent powder or tablet</a></li> <li><a href="/wiki/Herbal_tea" title="Herbal tea">Herbal tea</a></li> <li><a href="/wiki/Hydrogel" title="Hydrogel">Hydrogel</a></li> <li><a href="/wiki/Molecular_encapsulation" class="mw-redirect" title="Molecular encapsulation">Molecular encapsulation</a></li> <li><a href="/wiki/Powder" title="Powder">Powder</a></li> <li><a href="/wiki/Softgel" title="Softgel">Softgel</a></li> <li><a href="/wiki/Solution_(chemistry)" title="Solution (chemistry)">Solution</a></li> <li><a href="/wiki/Suspension_(chemistry)" title="Suspension (chemistry)">Suspension</a></li> <li><a href="/wiki/Syrup" title="Syrup">Syrup</a></li> <li><a href="/wiki/Tincture" title="Tincture">Tincture</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;white-space:normal;"><a href="/wiki/Oral_mucosa" title="Oral mucosa">Oral mucosa</a> (<a href="/wiki/Buccal_administration" title="Buccal administration">buccal</a>, <a href="/wiki/Sublabial_administration" title="Sublabial administration">sublabial</a>, <a href="/wiki/Sublingual_administration" title="Sublingual administration">sublingual</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;white-space:normal;"><a href="/wiki/Solid" title="Solid">Solids</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Orally_disintegrating_tablet" title="Orally disintegrating tablet">Orally disintegrating tablet</a></li> <li><a href="/wiki/Thin_film_drug_delivery" class="mw-redirect" title="Thin film drug delivery">Film</a></li> <li><a href="/wiki/Lollipop#Medicinal_use" title="Lollipop">Lollipop</a></li> <li><a href="/wiki/Drop_(liquid)" title="Drop (liquid)">Sublingual drops</a></li> <li><a href="/wiki/Throat_lozenge" title="Throat lozenge">Lozenges</a></li> <li><a href="/wiki/Effervescent" class="mw-redirect" title="Effervescent">Effervescent</a> tablet</li> <li><a href="/wiki/Chewing_gum" title="Chewing gum">Chewing gum</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;white-space:normal;"><a href="/wiki/Liquid" title="Liquid">Liquids</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mouthwash" title="Mouthwash">Mouthwash</a></li> <li><a href="/wiki/Toothpaste" title="Toothpaste">Toothpaste</a></li> <li><a href="/wiki/Topical" class="mw-redirect" title="Topical">Ointment</a></li> <li>Spray</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;white-space:normal;"><a href="/wiki/Respiratory_tract" title="Respiratory tract">Respiratory tract</a> (<a href="/wiki/Inhalation" title="Inhalation">inhalation</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;white-space:normal;"><a href="/wiki/Solid" title="Solid">Solids</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dry-powder_inhaler" title="Dry-powder inhaler">Dry-powder inhaler</a></li> <li><a href="/wiki/Smoking" title="Smoking">Smoking</a></li></ul> </div></td><td class="noviewer navbox-image" rowspan="3" style="width:1px;padding:0 0 0 2px"><div><span typeof="mw:File"><a href="/wiki/File:Inhaler.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Inhaler.jpg/60px-Inhaler.jpg" decoding="async" width="60" height="60" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Inhaler.jpg/90px-Inhaler.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b6/Inhaler.jpg/120px-Inhaler.jpg 2x" data-file-width="1704" data-file-height="1715" /></a></span><br /><span style="visibility:hidden;color:transparent;">0</span><br /><span style="visibility:hidden;color:transparent;">0</span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;white-space:normal;"><a href="/wiki/Liquid" title="Liquid">Liquids</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anesthetic_vaporizer" class="mw-redirect" title="Anesthetic vaporizer">Anesthetic vaporizer</a></li> <li><a href="/wiki/Heated_humidified_high-flow_therapy" title="Heated humidified high-flow therapy">Heated humidified high-flow therapy</a></li> <li><a href="/wiki/List_of_medical_inhalants" title="List of medical inhalants">Medical inhalants</a></li> <li><a href="/wiki/Metered-dose_inhaler" title="Metered-dose inhaler">Metered-dose inhaler</a> (MDI)</li> <li><a href="/wiki/Nebulizer" title="Nebulizer">Nebulizer</a></li> <li><a href="/wiki/Vaporizer_(inhalation_device)" title="Vaporizer (inhalation device)">Vaporizer</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;white-space:normal;"><a href="/wiki/Gas" title="Gas">Gas</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Oxygen_mask" title="Oxygen mask">Oxygen mask</a> and <a href="/wiki/Nasal_cannula" title="Nasal cannula">Nasal cannula</a></li> <li><a href="/wiki/Oxygen_concentrator" title="Oxygen concentrator">Oxygen concentrator</a></li> <li><a href="/wiki/Anaesthetic_machine" title="Anaesthetic machine">Anaesthetic machine</a></li> <li><a href="/wiki/List_of_medical_inhalants" title="List of medical inhalants">Medical inhalants</a></li> <li><a href="/wiki/Relative_analgesia_machine" title="Relative analgesia machine">Relative analgesia machine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ophthalmic_drug_administration" title="Ophthalmic drug administration">Ophthalmic</a>,<br /><a href="/wiki/Ear" title="Ear">otic</a>, <a href="/wiki/Nasal_administration" title="Nasal administration">nasal</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/File:Action_photo_of_nasal_spray_on_a_black_background.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Action_photo_of_nasal_spray_on_a_black_background.jpg/30px-Action_photo_of_nasal_spray_on_a_black_background.jpg" decoding="async" width="30" height="45" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Action_photo_of_nasal_spray_on_a_black_background.jpg/45px-Action_photo_of_nasal_spray_on_a_black_background.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a7/Action_photo_of_nasal_spray_on_a_black_background.jpg/60px-Action_photo_of_nasal_spray_on_a_black_background.jpg 2x" data-file-width="680" data-file-height="1024" /></a><figcaption></figcaption></figure> <ul><li><a href="/wiki/Nasal_spray" title="Nasal spray">Nasal spray</a></li> <li><a href="/wiki/Ear_drop" title="Ear drop">Ear drops</a></li> <li><a href="/wiki/Eye_drop" title="Eye drop">Eye drops</a></li> <li><a href="/wiki/Topical" class="mw-redirect" title="Topical">Ointment</a></li> <li><a href="/wiki/Hydrogel" title="Hydrogel">Hydrogel</a></li> <li><a href="/wiki/Insufflation_(medicine)" title="Insufflation (medicine)">Insufflation</a></li> <li><a href="/wiki/Bioadhesive" title="Bioadhesive">Mucoadhesive microdisc</a></li></ul></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Genitourinary_system" title="Genitourinary system">Urogenital</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <li><a href="/wiki/Topical" class="mw-redirect" title="Topical">Ointment</a></li> <li><a href="/wiki/Pessary" title="Pessary">Pessary</a></li> <li><a href="/wiki/Vaginal_ring" title="Vaginal ring">Vaginal ring</a></li> <li><a href="/wiki/Douche" title="Douche">Douche</a></li> <li><a href="/wiki/Intrauterine_device" title="Intrauterine device">Intrauterine device</a> (IUD)</li> <li><a href="/wiki/Extra-amniotic_administration" title="Extra-amniotic administration">Extra-amniotic infusion</a></li> <li><a href="/wiki/Urinary_bladder" class="mw-redirect" title="Urinary bladder">Intravesical infusion</a></li> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Rectal_(medicine)" class="mw-redirect" title="Rectal (medicine)">Rectal</a> (<a href="/wiki/Enteral_administration" title="Enteral administration">enteral</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/File:Glycerin_suppositories.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Glycerin_suppositories.jpg/30px-Glycerin_suppositories.jpg" decoding="async" width="30" height="23" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/98/Glycerin_suppositories.jpg/45px-Glycerin_suppositories.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/98/Glycerin_suppositories.jpg/60px-Glycerin_suppositories.jpg 2x" data-file-width="2126" data-file-height="1623" /></a><figcaption></figcaption></figure> <ul><li><a href="/wiki/Topical" class="mw-redirect" title="Topical">Ointment</a></li> <li><a href="/wiki/Suppository" title="Suppository">Suppository</a></li> <li><a href="/wiki/Enema" title="Enema">Enema</a> <ul><li><a href="/wiki/Solution_(chemistry)" title="Solution (chemistry)">Solution</a></li> <li><a href="/wiki/Hydrogel" title="Hydrogel">Hydrogel</a></li></ul></li> <li><a href="/wiki/Murphy_drip" title="Murphy drip">Murphy drip</a></li> <li><a href="/wiki/Nutrient_enema" title="Nutrient enema">Nutrient enema</a></li></ul></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Dermis" title="Dermis">Dermal</a> (<a href="/wiki/Topical_medication" title="Topical medication">topical</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/File:SPF15SunBlock.JPG" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/SPF15SunBlock.JPG/40px-SPF15SunBlock.JPG" decoding="async" width="40" height="55" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/SPF15SunBlock.JPG/60px-SPF15SunBlock.JPG 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9a/SPF15SunBlock.JPG/80px-SPF15SunBlock.JPG 2x" data-file-width="246" data-file-height="338" /></a><figcaption></figcaption></figure> <li><a href="/wiki/Topical" class="mw-redirect" title="Topical">Ointment</a></li> <li><a href="/wiki/Topical_cream" class="mw-redirect" title="Topical cream">Topical cream</a></li> <li><a href="/wiki/Topical_gel" class="mw-redirect" title="Topical gel">Topical gel</a></li> <li><a href="/wiki/Liniment" title="Liniment">Liniment</a></li> <li><a href="/wiki/Paste_(rheology)" title="Paste (rheology)">Paste</a></li> <li><a href="/wiki/Thin_film_drug_delivery" class="mw-redirect" title="Thin film drug delivery">Film</a></li> <li><a href="/wiki/Dimethyl_sulfoxide" title="Dimethyl sulfoxide">DMSO</a> solution</li> <li><a href="/wiki/Iontophoresis" title="Iontophoresis">Iontophoresis</a></li> <li><a href="/wiki/Hydrogel" title="Hydrogel">Hydrogel</a></li> <li><a href="/wiki/Liposome" title="Liposome">Liposomes</a></li> <li><a href="/wiki/Transfersome" title="Transfersome">Transfersome vesicles</a></li> <li><a href="/wiki/Cream_(pharmaceutical)" class="mw-redirect" title="Cream (pharmaceutical)">Cream</a></li> <li><a href="/wiki/Lotion" title="Lotion">Lotion</a></li> <li><a href="/wiki/Lip_balm" title="Lip balm">Lip balm</a></li> <li><a href="/wiki/Shampoo" title="Shampoo">Medicated shampoo</a></li> <li><a href="/wiki/Dermal_patch" title="Dermal patch">Dermal patch</a></li> <li><a href="/wiki/Transdermal_patch" title="Transdermal patch">Transdermal patch</a></li> <li><a href="/wiki/Transdermal_spray" title="Transdermal spray">Transdermal spray</a></li> <li><a href="/wiki/Jet_injector" title="Jet injector">Jet injector</a></li></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;"><div class="plainlist"><ul><li><a href="/wiki/Parenteral" class="mw-redirect" title="Parenteral">Parenterals</a></li><li><a href="/wiki/Injection_(medicine)" title="Injection (medicine)">Injections</a></li><li><a href="/wiki/Infusion_pump" title="Infusion pump">infusions</a></li></ul></div><br /><small><i>(into tissue/blood)</i></small></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;white-space:normal;"><a href="/wiki/Human_skin" title="Human skin">Skin</a> (<a href="/wiki/Transdermal" title="Transdermal">transdermal</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <li><a href="/wiki/Intradermal_injection" title="Intradermal injection">Intradermal</a></li> <li><a href="/wiki/Subcutaneous_injection" class="mw-redirect" title="Subcutaneous injection">Subcutaneous</a> <ul><li><a href="/wiki/Injector_pen" title="Injector pen">Injector pen</a></li></ul></li> <li><a href="/wiki/Transdermal_implant" title="Transdermal implant">Transdermal implant</a></li> </div></td><td class="noviewer navbox-image" rowspan="4" style="width:1px;padding:0 0 0 2px"><div><span typeof="mw:File"><a href="/wiki/File:Injection_Syringe_01.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Injection_Syringe_01.jpg/60px-Injection_Syringe_01.jpg" decoding="async" width="60" height="83" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Injection_Syringe_01.jpg/90px-Injection_Syringe_01.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Injection_Syringe_01.jpg/120px-Injection_Syringe_01.jpg 2x" data-file-width="1002" data-file-height="1386" /></a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;white-space:normal;"><a href="/wiki/Human_anatomy#Major_organ_systems" class="mw-redirect" title="Human anatomy">Organs</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Intracavernous_injection" title="Intracavernous injection">Intracavernous</a></li> <li><a href="/wiki/Intravitreal_administration" title="Intravitreal administration">Intravitreal</a></li> <li><a href="/wiki/Intra-articular_injection" class="mw-redirect" title="Intra-articular injection">Intra-articular</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;white-space:normal;"><a href="/wiki/Central_nervous_system" title="Central nervous system">Central nervous system</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Intracerebral_injection&action=edit&redlink=1" class="new" title="Intracerebral injection (page does not exist)">Intracerebral</a></li> <li><a href="/wiki/Intrathecal_administration" title="Intrathecal administration">Intrathecal</a></li> <li><a href="/wiki/Epidural_administration" title="Epidural administration">Epidural</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;white-space:normal;"><a href="/wiki/Circulatory_system" title="Circulatory system">Circulatory</a>,<br /><a href="/wiki/Human_musculoskeletal_system" title="Human musculoskeletal system">musculoskeletal</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous">Intravenous</a></li> <li><a href="/wiki/Intracardiac_injection" title="Intracardiac injection">Intracardiac</a></li> <li><a href="/wiki/Intramuscular_injection" title="Intramuscular injection">Intramuscular</a></li> <li><a href="/wiki/Intraosseous_infusion" title="Intraosseous infusion">Intraosseous</a></li> <li><a href="/wiki/Intraperitoneal_injection" title="Intraperitoneal injection">Intraperitoneal</a></li> <li><a href="/wiki/Nanocell" title="Nanocell">Nanocell injection</a></li> <li><a href="/wiki/Patient-controlled_analgesia" title="Patient-controlled analgesia">Patient-controlled analgesia</a> pump</li> <li><a href="/wiki/PIC_line" class="mw-redirect" title="PIC line">PIC line</a></li></ul> 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