Top 5 Questions on New Treatments for Chronic Hepatitis C Infection - *

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class="content-wrap edlab-content theme"> <div class="module"> <p class="pull-right"> </p> </div> <div id="main_0_ctl00_ctl01_divContentWrapper" class="cme-information"> <a name="ContentTop" id="ContentTop"></a> <a name="content"></a> <div class="top-10-questions"> <div id="col1" class="pull-left"> <a href="/web/20140911084349/http://www.healio.com/infectious-disease/education-lab/2013/08_august/top-5-questions-on-new-treatments-for-chronic-hepatitis-c-infection/q1"><div class="question-box-active"><ul class="list-unstyled"><li class="number-sm">1</li><li class="question">What are the potential targets for anti-hepatitis C medications?</li></ul></div></a> <a href="/web/20140911084349/http://www.healio.com/infectious-disease/education-lab/2013/08_august/top-5-questions-on-new-treatments-for-chronic-hepatitis-c-infection/q2"><div class="question-box"><ul class="list-unstyled"><li class="number-sm">2</li><li class="question">What new medications are on the horizon for treating HCV infection?</li></ul></div></a> <a href="/web/20140911084349/http://www.healio.com/infectious-disease/education-lab/2013/08_august/top-5-questions-on-new-treatments-for-chronic-hepatitis-c-infection/q3"><div class="question-box"><ul class="list-unstyled"><li class="number-sm">3</li><li class="question">What are the advantages of interferon-free therapy for the treatment of HCV infection?</li></ul></div></a> <a href="/web/20140911084349/http://www.healio.com/infectious-disease/education-lab/2013/08_august/top-5-questions-on-new-treatments-for-chronic-hepatitis-c-infection/q4"><div class="question-box"><ul class="list-unstyled"><li class="number-sm">4</li><li class="question">Will there be a role for interferon as a treatment for HCV in the future?</li></ul></div></a> <a href="/web/20140911084349/http://www.healio.com/infectious-disease/education-lab/2013/08_august/top-5-questions-on-new-treatments-for-chronic-hepatitis-c-infection/q5"><div class="question-box"><ul class="list-unstyled"><li class="number-sm">5</li><li class="question">Is there a vaccine for HCV infection?</li></ul></div></a> </div> <div id="col2" class="pull-left"><ul class="list-unstyled"><li class="number-lg">1</li><li class="question">What are the potential targets for anti-hepatitis C medications?</li></ul> <p>Direct-acting antiviral agents, or DAAs, target specific viral proteins that play a critical role in HCV replication. DAAs that are in advanced clinical development (phase III trials) include the following: <br> - NS3/4A protease inhibitors: simeprevir, faldaprevir, asunaprevir, ABT-450 <br> - NS5B polymerase inhibitors:<br> <span class="indented">• Nucleosides or nucleotides: sofosbuvir</span><br> <span class="indented">• Non-nucleosides: deleobuvir, ABT-333</span><br> - NS5A Inhibitors: Daclatasvir, ledipasvir, ABT-267 </p> <p class="info">Reference: <br> Manns MP, von Hahn T. Novel therapies for hepatitis C - one pill fits all? <em>Nat Rev Drug Discov</em>. 2013;12:595-610.</p> <ul class="module pager float-left">  <li class="next"><a href="/web/20140911084349/http://www.healio.com/infectious-disease/education-lab/2013/08_august/top-5-questions-on-new-treatments-for-chronic-hepatitis-c-infection/q2">Next »</a></li> </ul> <div class="ed-lab-presenter half-column"><h5>Presented by:</h5> <ul class="list-unstyled"><li><img class="thumbnail pull-left" width="70" height="90" src="https://web.archive.org/web/20140911084349im_/http://a1fbe0ec10afb4da94ef-0210b72318172f30f16fea29e4f8d202.r98.cf1.rackcdn.com/Alkhouri_mug.jpg"></li> <li class="name"><strong>Naim Alkhouri, MD</strong><br> Staff Physician<br> Digestive Disease Institute,<br> Cleveland Clinic</li> <li class="info">Disclosures: Alkhouri has served on advisory committees/review panels for Gilead Sciences, Inc., and performed speaking/teaching services for Merck & Co. and Vertex Pharmaceuticals.</li></ul> 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Top 5 Questions on New Treatments for Chronic Hepatitis C Infection - * | Infectious Disease Education Lab