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class="content-xs bg-color-teal-light"> <div class="container"> <div class="row"> <div class="col-sm-12"> <h1 class="font-size-30 fweight-400 color-white">Journal de m&eacute;decine r&eacute;g&eacute;n&eacute;rative </h1> </div> </div> </div> </div> <nav class="navbar navbar-expand-lg bg-navbar navbar-light mega-menu journal-menu topbar-shadow" id="mainNavbar"> <div class="container"> <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbarSupportedContent" aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-center" id="navbarSupportedContent"> <ul class="navbar-nav mb-auto mb-2 mb-lg-0"> <li class="nav-item"><a class="nav-link" href="https://french.scitechnol.com/journals/regenerative-medicine.html" title="Cliquez ici"><i class="fa fa-home" aria-hidden="true"></i></a></li> <li class="nav-item dropdown"> 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r&eacute;g&eacute;n&eacute;ration</h2> <p style="text-align: justify;"><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">La r&eacute;g&eacute;n&eacute;ration est sans doute l&rsquo;un des ph&eacute;nom&egrave;nes biologiques les plus inspirants connus. L&rsquo;histoire du canon occidental est peupl&eacute;e de nombreux exemples de l&rsquo;emprise aveugle et puissante exerc&eacute;e par la r&eacute;g&eacute;n&eacute;ration sur l&rsquo;esprit humain. Par exemple, lorsque Lazzaro Spallanzani a rapport&eacute; en 1768 que les escargots d&eacute;capit&eacute;s r&eacute;g&eacute;n&egrave;rent leur t&ecirc;te, les scientifiques, les philosophes et le public ont parcouru leurs jardins pour tenter de reproduire cette exp&eacute;rience fascinante (Odelberg, 2004). On a &eacute;galement d&eacute;couvert que les salamandres peuvent r&eacute;g&eacute;n&eacute;rer les membres et les queues (y compris la moelle &eacute;pini&egrave;re), tandis que les planaires peuvent r&eacute;g&eacute;n&eacute;rer des animaux entiers &agrave; partir de petits fragments de corps. Malgr&eacute; l&rsquo;int&eacute;r&ecirc;t de longue date port&eacute; &agrave; ce probl&egrave;me biologique et la connaissance que les animaux de tous horizons r&eacute;alisent des exploits r&eacute;g&eacute;n&eacute;ratifs, nous en sommes encore aux premiers stades de la description de ces &eacute;v&eacute;nements en termes cellulaires, mol&eacute;culaires et m&eacute;canistes. Cependant, les outils g&eacute;n&eacute;tiques et mol&eacute;culaires permettant de r&eacute;soudre le probl&egrave;me de la r&eacute;g&eacute;n&eacute;ration s&rsquo;am&eacute;liorent rapidement. Outre la curiosit&eacute; qu&rsquo;elle suscite habituellement, l&rsquo;&eacute;tude et la compr&eacute;hension de la r&eacute;g&eacute;n&eacute;ration pourraient avoir un impact consid&eacute;rable sur la pratique de la m&eacute;decine.</font></font></p> <p style="text-align: justify;"><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Tout aussi pertinente est la compr&eacute;hension d&eacute;coulant de l&rsquo;&eacute;tude des cellules souches, des cellules indiff&eacute;renci&eacute;es qui ont la capacit&eacute; de se remplacer ind&eacute;finiment et de produire des types cellulaires sp&eacute;cialis&eacute;s. Alors que les cellules souches embryonnaires se divisent et donnent finalement naissance &agrave; tous les types de cellules diff&eacute;renci&eacute;es du corps, les cellules souches adultes provenant de tissus sp&eacute;cifiques sont normalement une lign&eacute;e limit&eacute;e &agrave; un ensemble sp&eacute;cifique de types de cellules. Pour qu&rsquo;un animal adulte puisse remplacer les structures manquantes par une copie exacte de ce qui manque, il est clair que les programmes de d&eacute;veloppement doivent &ecirc;tre red&eacute;ploy&eacute;s. Cependant, la dynamique de la communication et de la prolif&eacute;ration cellulaire est tr&egrave;s diff&eacute;rente, tout comme les types de cellules impliqu&eacute;s. Pour r&eacute;aliser la r&eacute;g&eacute;n&eacute;ration, les animaux adultes peuvent invoquer la prolif&eacute;ration de cellules diff&eacute;renci&eacute;es, l&rsquo;activation de cellules souches de r&eacute;serve, la formation de nouvelles cellules souches ayant une capacit&eacute; limit&eacute;e &agrave; s&rsquo;auto-renouveller (cellules prog&eacute;nitrices) ou une combinaison de ces strat&eacute;gies.</font></font></p> <p style="text-align: justify;"><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Quelles cellules chez un animal adulte se divisent et se diff&eacute;rencient pour remplacer les multiples types de cellules requis lors d&rsquo;une r&eacute;ponse r&eacute;g&eacute;n&eacute;rative&nbsp;? Bien qu&rsquo;il s&rsquo;agisse d&rsquo;une question tr&egrave;s fondamentale, voire fondamentale, qui a &eacute;t&eacute; formul&eacute;e et reformul&eacute;e au fil des g&eacute;n&eacute;rations successives de biologistes, sa r&eacute;silience face aux attaques exp&eacute;rimentales s&rsquo;est r&eacute;v&eacute;l&eacute;e surprenante et, dans de nombreux cas, assez frustrante. N&eacute;anmoins, il est &eacute;vident que diff&eacute;rents tissus utilisent diff&eacute;rentes strat&eacute;gies pour parvenir &agrave; la r&eacute;paration ou &agrave; la r&eacute;g&eacute;n&eacute;ration tissulaire. Par exemple, le foie des vert&eacute;br&eacute;s invoque une r&eacute;g&eacute;n&eacute;ration compensatoire apr&egrave;s l&#39;ablation de deux lobes, le lobe restant prolif&eacute;rant pour r&eacute;acqu&eacute;rir la masse tissulaire d&#39;origine sans remplacer les lobes manquants. En fait, la r&eacute;g&eacute;n&eacute;ration peut &ecirc;tre compensatoire (foie), sp&eacute;cifique &agrave; un tissu (c&oelig;ur, muscle squelettique, foie, pancr&eacute;as, cristallin, r&eacute;tine), ou elle peut reconstruire des structures complexes contenant plusieurs types de tissus et d&#39;organes (par exemple, membres, nageoires, queues). . L&rsquo;objectif des chercheurs qui &eacute;tudient les organismes mod&egrave;les de r&eacute;g&eacute;n&eacute;ration est de d&eacute;couvrir comment ces animaux accomplissent naturellement la t&acirc;che apparemment impossible de restaurer les parties du corps perdues &agrave; la suite d&rsquo;un traumatisme.</font></font></p> </div> </div> <!-- sidebar --> <div class="col-xs-12 col-md-3"> <div class="divider-v4 divider-v4-left-double bg-color-white padding-10 margin-b-10"> <h2 class="divider-v4-title">Explorez SciTechnol</h2> <div> <ul class="list-unstyled angle-right"> <li class="color-base"><a href="https://french.scitechnol.com/author-guidelines.html" title="Cliquez ici"> Lignes directrices pour les auteurs</a></li> <li class="color-base"><a href="https://french.scitechnol.com/reviewer-guidelines.html" title="Cliquez ici"> Lignes directrices pour les 茅valuateurs</a></li> <li class="color-base"><a href="https://french.scitechnol.com/scitechnol-associations-indexing.html" 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