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The journal was created in response to the increasing number of researchers who were attempting to model human diseases in a range of experimentally tractable organisms. Since its launch, DMM has grown in impact to become a highly regarded platform for studies that connect basic and applied science using <em>in vitro</em> or <em>ex vivo</em> models, such as stem-cell-based models, organoids, patient material, model organisms, microorganisms, viruses, computational approaches and any other systems with relevance to human disease research.</p> <h2><span style="color: #00b4e0;">DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science.</span></h2> <p>DMM is interdisciplinary in <a href="https://journals.biologists.com/dmm/pages/aims">scope</a>, and covers a diverse range of diseases and model systems. It also publishes cutting-edge techniques and resources that advance the disease biology field. Its content is freely available to all communities of basic and clinical researchers, health professionals, patients and their advocates and families.</p> <p>The journal is led by an international team of expert <a href="https://journals.biologists.com/dmm/pages/editor-bios">research-active Editors</a>, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding <a href="https://journals.biologists.com/dmm/pages/edboard">Editorial Advisory Board</a>.</p> <p>Please refer to the <a href="https://journals.biologists.com/dmm">journal website</a>.</p> <p>DMM hosts occasional <a href="https://www.biologists.com/meetings/">Journal Meetings</a>, with a focus on networking and opportunities for attendees to more widely share their latest research.</p> <p>DMM is a fully Gold Open Access journal (articles are published under the CC-BY license). 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class="white-block"> <div class='story-from-shortcode stories'> <h4>A trip to Ireland for human organoid engineering – a Travelling Fellowship story from Disease Models & Mechanisms</h4> <p><em>16 May 2023</em></p> <p><img loading="lazy" decoding="async" data-attachment-id="16941" data-permalink="https://www.biologists.com/stories/a-trip-to-ireland-for-human-organoid-engineering-a-travelling-fellowship-story-from-disease-models-mechanisms/nore-van-loom-confocal-image-of-shield-fixed-neural-organoid-day-45-obtained-using-tau-contrast-feature-nuclei-are-stained-with-syto24-white-brackets-indicate-neural-rosettes/" data-orig-file="https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes..png" data-orig-size="801,801" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Nore Van Loom Confocal image of SHIELD fixed neural organoid (Day 45) obtained using ‘tau-contrast’ feature. Nuclei are stained with SYTO24. White brackets indicate neural rosettes." data-image-description="" data-image-caption="" data-medium-file="https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes.-300x300.png" data-large-file="https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes..png" class="wp-image-16941 size-medium" src="https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes.-300x300.png" alt="" width="300" height="300" srcset="https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes.-300x300.png 300w, https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes.-150x150.png 150w, https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes.-768x768.png 768w, https://www.biologists.com/wp-content/uploads/Nore-Van-Loom-Confocal-image-of-SHIELD-fixed-neural-organoid-Day-45-obtained-using-‘tau-contrast-feature.-Nuclei-are-stained-with-SYTO24.-White-brackets-indicate-neural-rosettes..png 801w" sizes="(max-width: 300px) 100vw, 300px" /></p> <p>Neurodevelopmental disorders (NDDs) represent a growing challenge in modern medicine and may give rise to impaired cognition, communication, and psychomotor skills. It is therefore very important that more sophisticated <em>in vitro </em>models are created to reveal the complexities of these disorders.</p> <p> …</p> <div class='buttons'> <p><a class='btn-type1' href='https://www.biologists.com/stories/a-trip-to-ireland-for-human-organoid-engineering-a-travelling-fellowship-story-from-disease-models-mechanisms/' >Read More</a></p> </div> </div> </div> <div class="white-block"> <p><a href="https://journals.biologists.com/dmm/pages/rights-permissions" target="_blank" rel="noopener noreferrer"><img loading="lazy" decoding="async" data-attachment-id="568" data-permalink="https://www.biologists.com/biology-open/transfer-to-biology-open-from-dev/cob-open-access-aw-rgb/" data-orig-file="https://www.biologists.com/wp-content/uploads/2015/07/CoB-open-access-AW-RGB.png" data-orig-size="228,227" data-comments-opened="1" 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