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<div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Enzyme</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">homoisocitrate dehydrogenase</th></tr><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/File:4yb4.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/4yb4.jpg/270px-4yb4.jpg" decoding="async" width="270" height="215" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/4yb4.jpg/405px-4yb4.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/85/4yb4.jpg/540px-4yb4.jpg 2x" data-file-width="1000" data-file-height="797" /></a></span><div class="infobox-caption">Homoisocitrate dehydrogenase tetramer, Thermus thermophilus</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.enzyme-database.org/query.php?ec=1.1.1.87">1.1.1.87</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/CAS_registry_number" class="mw-redirect" title="CAS registry number">CAS no.</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=37250-23-0&title=">37250-23-0 </a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Databases</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/IntEnz" title="IntEnz">IntEnz</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=1.1.1.87">IntEnz view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/BRENDA" title="BRENDA">BRENDA</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://www.brenda-enzymes.org/enzyme.php?ecno=1.1.1.87">BRENDA entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/ExPASy" class="mw-redirect" title="ExPASy">ExPASy</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.1.1.87">NiceZyme view</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+1.1.1.87">KEGG entry</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/MetaCyc" title="MetaCyc">MetaCyc</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://biocyc.org/META/substring-search?type=NIL&object=1.1.1.87">metabolic pathway</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/PRIAM_enzyme-specific_profiles" title="PRIAM enzyme-specific profiles">PRIAM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://priam.prabi.fr/cgi-bin/PRIAM_profiles_CurrentRelease.pl?EC=1.1.1.87">profile</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> structures</th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity.rcsb_ec_lineage.id:1.1.1.87">RCSB PDB</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?ec_number:1.1.1.87">PDBe</a> <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=1.1.1.87">PDBsum</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Gene_Ontology" title="Gene Ontology">Gene Ontology</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0047046">AmiGO </a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/term/GO:0047046">QuickGO</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=1.1.1.87%5BEC/RN%20Number%5D%20AND%20pubmed%20pmc%20local%5Bsb%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PubMed" title="PubMed">PubMed</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=1.1.1.87%5BEC/RN%20Number%5D">articles</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">NCBI</a></th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein?term=1.1.1.87%5BEC/RN%20Number%5D">proteins</a></td></tr></tbody></table></td></tr></tbody></table> <p>In <a href="/wiki/Enzymology" class="mw-redirect" title="Enzymology">enzymology</a>, a <b>homoisocitrate dehydrogenase</b> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.1.1.87">1.1.1.87</a>) is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that <a href="/wiki/Catalysis" title="Catalysis">catalyzes</a> the <a href="/wiki/Chemical_reaction" title="Chemical reaction">chemical reaction</a> </p> <dl><dd>(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD<sup>+</sup> <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle \rightleftharpoons }"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mo class="MJX-variant" stretchy="false">⇌</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle \rightleftharpoons }</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/1c37b981df851b9e54e489e017b1481e37d418f3" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:2.324ex; height:1.843ex;" alt="{\displaystyle \rightleftharpoons }"></span> 2-oxoadipate + CO<sub>2</sub> + NADH + H<sup>+</sup></dd></dl> <p>Thus, the two <a href="/wiki/Substrate_(biochemistry)" class="mw-redirect" title="Substrate (biochemistry)">substrates</a> of this enzyme are <a href="/wiki/(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate" class="mw-redirect" title="(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate">(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate</a> and <a href="/wiki/Nicotinamide_adenine_dinucleotide" title="Nicotinamide adenine dinucleotide">NAD<sup>+</sup></a>, whereas its 4 <a href="/wiki/Product_(chemistry)" title="Product (chemistry)">products</a> are <a href="/wiki/2-oxoadipate" class="mw-redirect" title="2-oxoadipate">2-oxoadipate</a>, <a href="/wiki/Carbon_dioxide" title="Carbon dioxide">CO<sub>2</sub></a>, <a href="/wiki/Nicotinamide_adenine_dinucleotide" title="Nicotinamide adenine dinucleotide">NADH</a>, and <a href="/wiki/Hydrogen_ion" title="Hydrogen ion">H<sup>+</sup></a>. </p><p>This enzyme belongs to the family of <a href="/wiki/Oxidoreductase" title="Oxidoreductase">oxidoreductases</a>, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The <a href="/wiki/List_of_enzymes" title="List of enzymes">systematic name</a> of this enzyme class is <b>(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD<sup>+</sup> oxidoreductase (decarboxylating)</b>. Other names in common use include <b>2-hydroxy-3-carboxyadipate dehydrogenase</b>, <b>3-carboxy-2-hydroxyadipate dehydrogenase</b>, <b>homoisocitric dehydrogenase</b>, <b>(−)-1-hydroxy-1,2,4-butanetricarboxylate:NAD<sup>+</sup> oxidoreductase</b>, <b>(decarboxylating)</b>, <b>3-carboxy-2-hydroxyadipate:NAD<sup>+</sup> oxidoreductase (decarboxylating)</b>, and <b>HICDH</b>. This enzyme participates in <a href="/wiki/Alpha-aminoadipate_pathway" class="mw-redirect" title="Alpha-aminoadipate pathway">lysine biosynthesis</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Structural_studies">Structural studies</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Homoisocitrate_dehydrogenase&action=edit&section=1" title="Edit section: Structural studies"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>As of late 2007, only one <a href="/wiki/Tertiary_structure" class="mw-redirect" title="Tertiary structure">structure</a> has been solved for this class of enzymes, with the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> accession code <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1X0L">1X0L</a>. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Homoisocitrate_dehydrogenase&action=edit&section=2" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width"> </div> <ul><li><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFStrassmanCeci1965" class="citation journal cs1">Strassman M, Ceci LN (1965). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0021-9258%2818%2997069-9">"Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid"</a>. <i>J. 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abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Alcohol_oxidoreductases" title="Template:Alcohol oxidoreductases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Alcohol_oxidoreductases" title="Template talk:Alcohol oxidoreductases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Alcohol_oxidoreductases" title="Special:EditPage/Template:Alcohol oxidoreductases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Oxidoreductases:_alcohol_oxidoreductases_(EC_1.1)" style="font-size:114%;margin:0 4em"><a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a>: <a href="/wiki/Alcohol_oxidoreductase" title="Alcohol oxidoreductase">alcohol oxidoreductases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.1)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.1.1_With_NAD_or_NADP_as_acceptor" title="List of EC numbers (EC 1)">1.1.1</a>: <a href="/wiki/Nicotinamide_adenine_dinucleotide" title="Nicotinamide adenine dinucleotide">NAD</a>/<a href="/wiki/Nicotinamide_adenine_dinucleotide_phosphate" title="Nicotinamide adenine dinucleotide phosphate">NADP</a> acceptor</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3-hydroxyacyl-CoA_dehydrogenase" title="3-hydroxyacyl-CoA dehydrogenase">3-hydroxyacyl-CoA dehydrogenase</a></li> <li><a href="/wiki/3-hydroxybutyryl-CoA_dehydrogenase" class="mw-redirect" title="3-hydroxybutyryl-CoA dehydrogenase">3-hydroxybutyryl-CoA dehydrogenase</a></li> <li><a href="/wiki/Alcohol_dehydrogenase" title="Alcohol dehydrogenase">Alcohol dehydrogenase</a></li> <li><a href="/wiki/Aldo-keto_reductase" title="Aldo-keto reductase">Aldo-keto reductase</a> <ul><li><a href="/wiki/Aldo-keto_reductase_family_1,_member_A1" title="Aldo-keto reductase family 1, member A1">1A1</a></li> <li><a href="/wiki/AKR1B1" title="AKR1B1">1B1</a></li> <li><a href="/wiki/AKR1B10" title="AKR1B10">1B10</a></li> <li><a href="/wiki/AKR1C1" title="AKR1C1">1C1</a></li> <li><a href="/wiki/AKR1C3" title="AKR1C3">1C3</a></li> <li><a href="/wiki/AKR1C4" title="AKR1C4">1C4</a></li> <li><a href="/wiki/AKR7A2" title="AKR7A2">7A2</a></li></ul></li> <li><a href="/wiki/Aldose_reductase" title="Aldose reductase">Aldose reductase</a></li> <li><a href="/wiki/Beta-Ketoacyl_ACP_reductase" class="mw-redirect" title="Beta-Ketoacyl ACP reductase">Beta-Ketoacyl ACP reductase</a></li> <li><a href="/wiki/Carbohydrate_dehydrogenase" title="Carbohydrate dehydrogenase">Carbohydrate dehydrogenases</a></li> <li><a href="/wiki/Carnitine_dehydrogenase" class="mw-redirect" title="Carnitine dehydrogenase">Carnitine dehydrogenase</a></li> <li><a href="/wiki/D-malate_dehydrogenase_(decarboxylating)" title="D-malate dehydrogenase (decarboxylating)">D-malate dehydrogenase (decarboxylating)</a></li> <li><a href="/wiki/DXP_reductoisomerase" title="DXP reductoisomerase">DXP reductoisomerase</a></li> <li><a href="/wiki/Glucose-6-phosphate_dehydrogenase" title="Glucose-6-phosphate dehydrogenase">Glucose-6-phosphate dehydrogenase</a></li> <li><a href="/wiki/Glycerol-3-phosphate_dehydrogenase" title="Glycerol-3-phosphate dehydrogenase">Glycerol-3-phosphate dehydrogenase</a></li> <li><a href="/wiki/HMG-CoA_reductase" title="HMG-CoA reductase">HMG-CoA reductase</a></li> <li><a href="/wiki/IMP_dehydrogenase" class="mw-redirect" title="IMP dehydrogenase">IMP dehydrogenase</a></li> <li><a href="/wiki/Isocitrate_dehydrogenase" title="Isocitrate dehydrogenase">Isocitrate dehydrogenase</a></li> <li><a href="/wiki/Lactate_dehydrogenase" title="Lactate dehydrogenase">Lactate dehydrogenase</a></li> <li><a href="/wiki/L-threonine_dehydrogenase" class="mw-redirect" title="L-threonine dehydrogenase">L-threonine dehydrogenase</a></li> <li><a href="/wiki/L-xylulose_reductase" title="L-xylulose reductase">L-xylulose reductase</a></li> <li><a href="/wiki/Malate_dehydrogenase" title="Malate dehydrogenase">Malate dehydrogenase</a></li> <li><a href="/wiki/Malate_dehydrogenase_(decarboxylating)" title="Malate dehydrogenase (decarboxylating)">Malate dehydrogenase (decarboxylating)</a></li> <li><a href="/wiki/Malate_dehydrogenase_(NADP%2B)" title="Malate dehydrogenase (NADP+)">Malate dehydrogenase (NADP+)</a></li> <li><a href="/wiki/Malate_dehydrogenase_(oxaloacetate-decarboxylating)" title="Malate dehydrogenase (oxaloacetate-decarboxylating)">Malate dehydrogenase (oxaloacetate-decarboxylating)</a></li> <li><a href="/wiki/Malate_dehydrogenase_(oxaloacetate-decarboxylating)_(NADP%2B)" title="Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)">Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)</a></li> <li><a href="/wiki/Phosphogluconate_dehydrogenase" class="mw-redirect" title="Phosphogluconate dehydrogenase">Phosphogluconate dehydrogenase</a></li> <li><a href="/wiki/Sorbitol_dehydrogenase" title="Sorbitol dehydrogenase">Sorbitol dehydrogenase</a></li></ul> <ul><li><i><a href="/wiki/Hydroxysteroid_dehydrogenase" title="Hydroxysteroid dehydrogenase">Hydroxysteroid dehydrogenase</a>:</i> <a href="/wiki/3-beta-HSD" class="mw-redirect" title="3-beta-HSD">3β</a> <ul><li><a href="/wiki/3%CE%B2-HSD" class="mw-redirect" title="3β-HSD">3β-HSD</a></li> <li><a href="/wiki/NSDHL" title="NSDHL">NSDHL</a></li></ul></li> <li><a href="/wiki/11-Beta_hydroxysteroid_dehydrogenase" class="mw-redirect" title="11-Beta hydroxysteroid dehydrogenase">11β</a> <ul><li><a href="/wiki/11%CE%B2-hydroxysteroid_dehydrogenase_type_1" class="mw-redirect" title="11β-hydroxysteroid dehydrogenase type 1">11β-HSD1</a></li> <li><a href="/wiki/Corticosteroid_11-beta-dehydrogenase_isozyme_2" title="Corticosteroid 11-beta-dehydrogenase isozyme 2">11β-HSD2</a></li></ul></li> <li><a href="/wiki/17Beta_Hydroxysteroid_dehydrogenase" class="mw-redirect" title="17Beta Hydroxysteroid dehydrogenase">17β</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.1.2_With_a_cytochrome_as_acceptor" title="List of EC numbers (EC 1)">1.1.2</a>: <a href="/wiki/Cytochrome" title="Cytochrome">cytochrome</a> acceptor</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/D-lactate_dehydrogenase_(cytochrome)" title="D-lactate dehydrogenase (cytochrome)">D-lactate dehydrogenase (cytochrome)</a></li> <li><a href="/wiki/D-lactate_dehydrogenase_(cytochrome_c-553)" title="D-lactate dehydrogenase (cytochrome c-553)">D-lactate dehydrogenase (cytochrome c-553)</a></li> <li><a href="/wiki/Mannitol_dehydrogenase_(cytochrome)" title="Mannitol dehydrogenase (cytochrome)">Mannitol dehydrogenase (cytochrome)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.1.3_With_oxygen_as_acceptor" title="List of EC numbers (EC 1)">1.1.3</a>: <a href="/wiki/Oxygen" title="Oxygen">oxygen</a> acceptor</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glucose_oxidase" title="Glucose oxidase">Glucose oxidase</a></li> <li><a href="/wiki/L-gulonolactone_oxidase" title="L-gulonolactone oxidase">L-gulonolactone oxidase</a></li> <li><a href="/wiki/Xanthine_oxidase" title="Xanthine oxidase">Xanthine oxidase</a></li> <li><a href="/wiki/Alcohol_oxidase" title="Alcohol oxidase">Alcohol oxidase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.1.4_With_a_disulfide_as_acceptor" title="List of EC numbers (EC 1)">1.1.4</a>: <a href="/wiki/Disulfide" title="Disulfide">disulfide</a> as acceptor</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vitamin_K_epoxide_reductase" title="Vitamin K epoxide reductase">Vitamin K epoxide reductase</a></li> <li><a href="/wiki/Vitamin-K-epoxide_reductase_(warfarin-insensitive)" title="Vitamin-K-epoxide reductase (warfarin-insensitive)">Vitamin-K-epoxide reductase (warfarin-insensitive)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.1.5_With_a_quinone_or_similar_compound_as_acceptor" title="List of EC numbers (EC 1)">1.1.5</a>: <a href="/wiki/Quinone" title="Quinone">quinone</a>/similar acceptor</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Malate_dehydrogenase_(quinone)" title="Malate dehydrogenase (quinone)">Malate dehydrogenase (quinone)</a></li> <li><a href="/wiki/Quinoprotein_glucose_dehydrogenase" title="Quinoprotein glucose dehydrogenase">Quinoprotein glucose dehydrogenase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/List_of_EC_numbers_(EC_1)#EC_1.1.99_With_other_acceptors" title="List of EC numbers (EC 1)">1.1.99</a>: other acceptors</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Choline_dehydrogenase" title="Choline dehydrogenase">Choline dehydrogenase</a></li> <li><a href="/wiki/L2HGDH" title="L2HGDH">L2HGDH</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output 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