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transdermal</title> <meta name="description" content="Search results for: transdermal"> <meta name="keywords" content="transdermal"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="transdermal"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 36</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: transdermal</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">36</span> Iontophoretic Drug Transport: An Non-Invasive Transdermal Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ashish%20Jain">Ashish Jain</a>, <a href="https://publications.waset.org/abstracts/search?q=Shivam%20Tayal"> Shivam Tayal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> There has been great interest in the field of Iontophoresis since few years due to its great applications in the field of controlled transdermal drug delivery system. It is an technique which is used to enhance the transdermal permeation of ionized high molecular weight molecules across the skin membrane especially Peptides & Proteins by the application of direct current of 1-4 mA for 20-40 minutes whereas chemical must be placed on electrodes with same charge. Iontophoresis enhanced the delivery of drug into the skin via pores like hair follicles, sweat gland ducts etc. rather than through stratum corneum. It has wide applications in the field of experimental, Therapeutic, Diagnostic, Dentistry etc. Medical science is using it to treat Hyperhidrosis (Excessive sweating) in hands and feet and to treat other ailments like hypertension, Migraine etc. Nowadays commercial transdermal iontophoretic patches are available in the market to treat different ailments. Researchers are keen to research in this field due to its vast applications and advantages. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=iontophoresis" title="iontophoresis">iontophoresis</a>, <a href="https://publications.waset.org/abstracts/search?q=novel%20drug%20delivery" title=" novel drug delivery"> novel drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a>, <a href="https://publications.waset.org/abstracts/search?q=permeation%20enhancer" title=" permeation enhancer"> permeation enhancer</a> </p> <a href="https://publications.waset.org/abstracts/78410/iontophoretic-drug-transport-an-non-invasive-transdermal-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78410.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">254</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">35</span> Transdermal Therapeutic System of Lercanıdipine Hydrochloride: Fabrication and in Vivo Evaluation </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jiji%20Jose">Jiji Jose</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Narayanacharyulu"> R. Narayanacharyulu</a>, <a href="https://publications.waset.org/abstracts/search?q=Molly%20Mathew"> Molly Mathew</a>, <a href="https://publications.waset.org/abstracts/search?q=Jisha%20Prems"> Jisha Prems</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Lercanidipine hydrochloride (LD), an effective calcium channel blocker, widely used for the treatment of chronic stable angina and hypertension seems to be potential transdermal therapeutic system candidate, mainly due to its low oral bio availability, short half life and high first-pass metabolism. Objective: To develop transdermal therapeutic systems for LD and to evaluate its in vivo performance in rabbits. Methodology: Transdermal patches of LD were formulated using the polymer blend of eudragit RL100 (ERL) and polyvinyl pyrolidone (PVP) by casting method Propylene glycol (PG) and tween 80 were used as plasticizer and permeation enhancer respectively. The pharmaco kinetic parameters of LD after the administration of transdermal patches was compared with that of oral administration. The study was carried out in a two way crossover design in male New Zealand albino rabbits. Results: The formulation with ERL: PVP ratio 1:4 with 15% w/w PG as plasticizer and 4% w/w tween 80 as permeation enhancer showed the best drug release results. The pharmacokinetic parameters such as Cmax, tmax, mean residence time (MRT) and area under the curve (AUC 0-∞) were significantly different following transdermal administration compared to oral administration. The terminal half life of transdermally administered LD was found to similar that of oral administration. A sustained drug release over a period of 24 hrs was observed after transdermal administration. Conclusion: The fabricated transdermal delivery system have the potential to provide controlled and extended drug release, better bio availability and thus, this may improve the patient compliance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal%20therapeutic%20system" title="transdermal therapeutic system">transdermal therapeutic system</a>, <a href="https://publications.waset.org/abstracts/search?q=lercanidipine%20hydrochloride" title=" lercanidipine hydrochloride"> lercanidipine hydrochloride</a>, <a href="https://publications.waset.org/abstracts/search?q=eudragit" title=" eudragit"> eudragit</a>, <a href="https://publications.waset.org/abstracts/search?q=skinpermeation" title=" skinpermeation"> skinpermeation</a> </p> <a href="https://publications.waset.org/abstracts/10017/transdermal-therapeutic-system-of-lercanidipine-hydrochloride-fabrication-and-in-vivo-evaluation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10017.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">615</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">34</span> The Effect of Backing Layer on Adhesion Properties of Single Layer Ketoprofen Transdermal Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Maryam%20Hamedanlou">Maryam Hamedanlou</a>, <a href="https://publications.waset.org/abstracts/search?q=Shahla%20Hajializadeh"> Shahla Hajializadeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The transdermal drug delivery system is one of the types of novel drug delivery system that the drug is absorbed into the skin. The major considerations for designing and producing transdermal patch are small size, suitable drug release and good adhering. In this study, drug-in-adhesive transdermal patch contained non-steroidal anti-inflammatory ketoprofen is prepared. Also, the effect of non-woven fabric and plastic backing layers on adhesion properties is assessed. The results of the test, demonstrated the use of plastic backing layer increases tack and peel rather than non-woven fabric type. The balance tack with plastic backing layer patch is 6.7 (N/mm2), and the fabric one is 3.8 (N/mm2), and their peel is 9.2 (N/25mm) and 8.3 (N/25mm) by arrangement. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery%20system" title="transdermal drug delivery system">transdermal drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=single%20layer%20patch%20of%20ketoprofen" title=" single layer patch of ketoprofen"> single layer patch of ketoprofen</a>, <a href="https://publications.waset.org/abstracts/search?q=plastic%20layer" title=" plastic layer"> plastic layer</a>, <a href="https://publications.waset.org/abstracts/search?q=fabric%20backing%20layer" title=" fabric backing layer"> fabric backing layer</a> </p> <a href="https://publications.waset.org/abstracts/55471/the-effect-of-backing-layer-on-adhesion-properties-of-single-layer-ketoprofen-transdermal-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55471.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">252</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">33</span> Fabrication and Characterization of Dissolvable Microneedle Patches Using Different Compositions and Ratios of Hyaluronic Acid and Zinc Oxide Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dada%20Kolawole%20Segun">Dada Kolawole Segun</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Transdermal drug delivery has gained popularity as a non-invasive method for controlled drug release compared to traditional delivery routes. Dissolvable transdermal patches have emerged as a promising platform for delivering a variety of drugs due to their ease of use. The objective of this research was to create and characterize dissolvable transdermal patches using various compositions and ratios of hyaluronic acid and zinc oxide nanoparticles. A micromolding technique was utilized to fabricate the patches, which were subsequently characterized using scanning electron microscopy, atomic force microscopy, and tensile strength testing. In vitro drug release studies were conducted to evaluate the drug release kinetics of the patches. The study found that the mechanical strength and dissolution properties of the patches were influenced by the hyaluronic acid and zinc oxide nanoparticle ratios used in the fabrication process. Moreover, the patches demonstrated controlled delivery of model drugs through the skin, highlighting their potential for transdermal drug delivery applications. The results suggest that dissolvable transdermal patches can be tailored to meet specific requirements for drug delivery applications using different compositions and ratios of hyaluronic acid and zinc oxide nanoparticles. This development has the potential to improve treatment outcomes and patient compliance in various therapeutic areas. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery" title="transdermal drug delivery">transdermal drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=characterization" title=" characterization"> characterization</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20permeation" title=" skin permeation"> skin permeation</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20materials" title=" biodegradable materials"> biodegradable materials</a> </p> <a href="https://publications.waset.org/abstracts/166832/fabrication-and-characterization-of-dissolvable-microneedle-patches-using-different-compositions-and-ratios-of-hyaluronic-acid-and-zinc-oxide-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/166832.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">90</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">32</span> Effect of Span 60, Labrasol, and Cholesterol on Labisia pumila Loaded Niosomes Quality</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Binti%20Ya%E2%80%99akob">H. Binti Ya’akob</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Siew%20Chin"> C. Siew Chin</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Abd%20Aziz"> A. Abd Aziz</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Ware"> I. Ware</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Fauzi%20Abd%20Jalil"> M. Fauzi Abd Jalil</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Rashidah%20Ahmed"> N. Rashidah Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Sabtu"> R. Sabtu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <em>Labisia pumila</em> (LP) plant extract has the potential to be applied in cosmeceutical products due to its anti-photoaging properties. The main purpose of this study was to improve transdermal delivery of LP by encapsulating LP in niosomes. Niosomes loaded LPs were prepared by coacervation phase separation method using non-ionic surfactant (Span 60), labrasol, and cholesterol. The optimum formula obtained were Span 60, labrasol and cholesterol at the mole ratio of 6:1:4. At the optimum formulation, the niosome obtained significantly improved the quality of transdermal penetration of LP compared to free LP. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Labisia%20pumila" title="Labisia pumila">Labisia pumila</a>, <a href="https://publications.waset.org/abstracts/search?q=niosomes" title=" niosomes"> niosomes</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a>, <a href="https://publications.waset.org/abstracts/search?q=quality" title=" quality"> quality</a> </p> <a href="https://publications.waset.org/abstracts/71190/effect-of-span-60-labrasol-and-cholesterol-on-labisia-pumila-loaded-niosomes-quality" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71190.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">315</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">31</span> Iontophoretic Drug Transport of Some Anti-Diabetic Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ashish%20Jain">Ashish Jain</a>, <a href="https://publications.waset.org/abstracts/search?q=Satish%20Nayak"> Satish Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Transdermal iontophoretic drug delivery system is viable drug delivery platform technology and has a strong market worldwide. Transdermal drug delivery system is particularly desirable for therapeutic agents that need prolonged administration at controlled plasma level. This makes appropriateness to antihypertensive and anti-diabetic agents for their transdermal development. Controlled zero order absorption, easily termination of drug delivery and easy to administration also support for popularity of transdermal delivery. In this current research iontophoretic delivery of various anti diabetic agents like glipizide, glibenclamide and glimepiride were carried out. The experiments were carried out at different drug concentrations and different current densities using cathodal iontophoresis. Diffusion cell for iontophoretic permeation study was modified according to Glikfield Design. Pig skin was used for in vitro permeation study and for the in-vivo study New Zealand rabbits were used. At all concentration level iontophoresis showed enhanced permeation rate compared to passive controls. Iontophoretic transports of selected drugs were found to be increased with the current densities. Results showed that target permeation rate for selected drugs could be achieved with the aid of iontophoresis by increasing the area in an appreciable range. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal" title="transdermal">transdermal</a>, <a href="https://publications.waset.org/abstracts/search?q=iontophoresis" title=" iontophoresis"> iontophoresis</a>, <a href="https://publications.waset.org/abstracts/search?q=pig%20skin" title=" pig skin"> pig skin</a>, <a href="https://publications.waset.org/abstracts/search?q=rabbits" title=" rabbits"> rabbits</a>, <a href="https://publications.waset.org/abstracts/search?q=glipizide" title=" glipizide"> glipizide</a>, <a href="https://publications.waset.org/abstracts/search?q=glibeclamide" title=" glibeclamide"> glibeclamide</a> </p> <a href="https://publications.waset.org/abstracts/45635/iontophoretic-drug-transport-of-some-anti-diabetic-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45635.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">384</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">30</span> Design, Development and Characterization of Pioglitazone Transdermal Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dwarakanadha%20Reddy%20Peram">Dwarakanadha Reddy Peram</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Swarnalatha"> D. Swarnalatha</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Gopinath"> C. Gopinath</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main aim of this research work was to design and development characterization of Pioglitazone transdermal drug delivery system by using various polymers such as Olibanum with different concentration by solvent evaporation technique. The prepared formulations were evaluated for different physicochemical characteristics like thickness, folding endurance, drug content, percentage moisture absorption, percentage moisture loss, percentage elongation break test and weight uniformity. The diffusion studies were performed by using modified Franz diffusion cells. The result of dissolution studies shows that formulation, F3 (Olibanum with 50 mg) showed maximum release of 99.95 % in 12hrs, whereas F1 (Olibanum and EC backing membrane) showed minimum release of 93.65% in 12 hr. Based on the drug release and physicochemical values obtained the formulation F3 is considered as an optimized formulation which shows higher percentage of drug release of 99.95 % in 12 hr. The developed transdermal patches increase the therapeutic efficacy and reduced toxic effect of pioglitazone. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pioglitazone" title="pioglitazone">pioglitazone</a>, <a href="https://publications.waset.org/abstracts/search?q=olibanum" title=" olibanum"> olibanum</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery%20system" title=" transdermal drug delivery system"> transdermal drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20percantage" title=" drug release percantage"> drug release percantage</a> </p> <a href="https://publications.waset.org/abstracts/85414/design-development-and-characterization-of-pioglitazone-transdermal-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85414.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">208</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">29</span> Fabrication and Characterization of Transdermal Spray Using Film Forming Polymer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Paresh%20Patel">Paresh Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=Harshit%20Patel"> Harshit Patel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Superficial fungal skin infection is among the most common skin disease. The drug administration through skin has received attention due to several advantages: Avoidance of significant pre-systemic metabolism, drug levels within the therapeutic window, drugs with short biological half-lives, decreased side effects, the non-invasive character, and very high acceptance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal%20spray" title="transdermal spray">transdermal spray</a>, <a href="https://publications.waset.org/abstracts/search?q=ketoconazole" title=" ketoconazole"> ketoconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=Eudragit%C2%AE%20RLPO" title=" Eudragit® RLPO"> Eudragit® RLPO</a>, <a href="https://publications.waset.org/abstracts/search?q=therapeutic%20window" title=" therapeutic window"> therapeutic window</a> </p> <a href="https://publications.waset.org/abstracts/2306/fabrication-and-characterization-of-transdermal-spray-using-film-forming-polymer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2306.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">399</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">28</span> Formulation of Film Forming Transdermal Spray Containing Fluconazole Using Full Factorial Design</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Paresh%20M.%20Patel">Paresh M. Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=Amit%20A.%20Patel"> Amit A. Patel</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20H.%20Parikh"> R. H. Parikh </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present investigation was undertaken to fabricate modified transport fluconazole that belongs to BCS class II and have a poor applicability on topical infection. So to improve topical application, transdermal spray could play a vital role by using ethyl cellulose and Eudragit® S100 as film-forming polymers. Concentration of Eudragit® S100, ethyl cellulose and permeation enhancer (camphor and menthol) were selected as independent variables, whereas drying time, viscosity and in-vitro drug release were selected as dependent variables in factorial design. The viscosity, drying time and in-vitro drug release of the optimize batch B15 was 40.1 cps, 47 sec. and 90.79% respectively. The film of optimized batch was flexible and dermal-adhesive. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eudragit" title="Eudragit">Eudragit</a>, <a href="https://publications.waset.org/abstracts/search?q=ethyl%20cellulose" title=" ethyl cellulose"> ethyl cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=fluconazole" title=" fluconazole"> fluconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal%20spray" title=" transdermal spray"> transdermal spray</a> </p> <a href="https://publications.waset.org/abstracts/14151/formulation-of-film-forming-transdermal-spray-containing-fluconazole-using-full-factorial-design" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14151.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">456</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">27</span> Transdermal Medicated- Layered Extended-Release Patches for Co-delivery of Carbamazepine and Pyridoxine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sarah%20K.%20Amer">Sarah K. Amer</a>, <a href="https://publications.waset.org/abstracts/search?q=Walaa%20Alaa"> Walaa Alaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Epilepsy is an important cause of mortality and morbidity, according to WHO statistics. It is characterized by the presence of frequent seizures occurring more than 24 hours apart. Carbamazepine (CBZ) is considered first-line treatment for epilepsy. However, reports have shown that CBZ oral formulations failed to achieve optimum systemic delivery, minimize side effects, and enhance patient compliance. Besides, the literature has signified the lack of therapeutically efficient CBZ transdermal formulation and the urge for its existence owing to its ease and convenient method of application and highlighted capability to attain higher bioavailability and more extended-release profiles compared to conventional oral CBZ tablets. This work aims to prepare CBZ microspheres (MS) that are embedded in a transdermal gel containing Vitamin B to be co-delivered. MS were prepared by emulsion-solvent diffusion method using Eudragit S as core forming polymer and hydroxypropyl methylcellulose (HPMC) polymer. The MS appeared to be spherical and porous in nature, offering a large surface area and high entrapment efficiency of CBZ. The transdermal gel was prepared by solvent-evaporation technique using HPMC that, offered high entrapment efficiency and Eudragit S that provided an extended-release profile. Polyethylene glycol, Span 80 and Pyridoxine were also added. Data indicated that combinations of CBZ with pyridoxine can reduce epileptic seizures without affecting motor coordination. Extended-release profiles were evident for this system. The patches were furthermore tested for thickness, moisture content, folding endurance, spreadability and viscosity measurements. This novel pharmaceutical formulation would be of great influence on seizure control, offering better therapeutic effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epilepsy" title="epilepsy">epilepsy</a>, <a href="https://publications.waset.org/abstracts/search?q=carbamazepine" title=" carbamazepine"> carbamazepine</a>, <a href="https://publications.waset.org/abstracts/search?q=pyridoxine" title=" pyridoxine"> pyridoxine</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a> </p> <a href="https://publications.waset.org/abstracts/182988/transdermal-medicated-layered-extended-release-patches-for-co-delivery-of-carbamazepine-and-pyridoxine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/182988.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">59</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">26</span> Formulation, Evaluation and Statistical Optimization of Transdermal Niosomal Gel of Atenolol</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lakshmi%20Sirisha%20Kotikalapudi">Lakshmi Sirisha Kotikalapudi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Atenolol, the widely used antihypertensive drug is ionisable and degrades in the acidic environment of the GIT lessening the bioavailability. Transdermal route may be selected as an alternative to enhance the bioavailability. Half-life of the drug is 6-7 hours suggesting the requirement of prolonged release of the drug. The present work of transdermal niosomal gel aims to extend release of the drug and increase the bioavailability. Ethanol injection method was used for the preparation of niosomes using span-60 and cholesterol at different molar ratios following central composite design. The prepared niosomes were characterized for size, zeta-potential, entrapment efficiency, drug content and in-vitro drug release. Optimized formulation was selected by statistically analyzing the results obtained using the software Stat-Ease Design Expert. The optimized formulation also showed high drug retention inside the vesicles over a period of three months at a temperature of 4 °C indicating stability. Niosomes separated as a pellet were dried and incorporated into the hydrogel prepared using chitosan a natural polymer as a gelling agent. The effect of various chemical permeation enhancers was also studied over the gel formulations. The prepared formulations were characterized for viscosity, pH, drug release using Franz diffusion cells, and skin irritation test as well as in-vivo pharmacological activities. Atenolol niosomal gel preparations showed the prolonged release of the drug and pronounced antihypertensive activity indicating the suitability of niosomal gel for topical and systemic delivery of atenolol. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=atenolol" title="atenolol">atenolol</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=niosomes" title=" niosomes"> niosomes</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a> </p> <a href="https://publications.waset.org/abstracts/59549/formulation-evaluation-and-statistical-optimization-of-transdermal-niosomal-gel-of-atenolol" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59549.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25</span> Combined Effect of Vesicular System and Iontophoresis on Skin Permeation Enhancement of an Analgesic Drug </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jigar%20N.%20Shah">Jigar N. Shah</a>, <a href="https://publications.waset.org/abstracts/search?q=Hiral%20J.%20Shah"> Hiral J. Shah</a>, <a href="https://publications.waset.org/abstracts/search?q=Praful%20D.%20Bharadia"> Praful D. Bharadia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The major challenge faced by formulation scientists in transdermal drug delivery system is to overcome the inherent barriers related to skin permeation. The stratum corneum layer of the skin is working as the rate limiting step in transdermal transport and reduce drug permeation through skin. Many approaches have been used to enhance the penetration of drugs through this layer of the skin. The purpose of this study is to investigate the development and evaluation of a combined approach of drug carriers and iontophoresis as a vehicle to improve skin permeation of an analgesic drug. Iontophoresis is a non-invasive technique for transporting charged molecules into and through tissues by a mild electric field. It has been shown to effectively deliver a variety of drugs across the skin to the underlying tissue. In addition to the enhanced continuous transport, iontophoresis allows dose titration by adjusting the electric field, which makes personalized dosing feasible. Drug carrier could modify the physicochemical properties of the encapsulated molecule and offer a means to facilitate the percutaneous delivery of difficult-to-uptake substances. Recently, there are some reports about using liposomes, microemulsions and polymeric nanoparticles as vehicles for iontophoretic drug delivery. Niosomes, the nonionic surfactant-based vesicles that are essentially similar in properties to liposomes have been proposed as an alternative to liposomes. Niosomes are more stable and free from other shortcoming of liposomes. Recently, the transdermal delivery of certain drugs using niosomes has been envisaged and niosomes have proved to be superior transdermal nanocarriers. Proniosomes overcome some of the physical stability related problems of niosomes. The proniosomal structure was liquid crystalline-compact niosomes hybrid which could be converted into niosomes upon hydration. The combined use of drug carriers and iontophoresis could offer many additional benefits. The system was evaluated for Encapsulation Efficiency, vesicle size, zeta potential, Transmission Electron Microscopy (TEM), DSC, in-vitro release, ex-vivo permeation across skin and rate of hydration. The use of proniosomal gel as a vehicle for the transdermal iontophoretic delivery was evaluated in-vitro. The characteristics of the applied electric current, such as density, type, frequency, and on/off interval ratio were observed. The study confirms the synergistic effect of proniosomes and iontophoresis in improving the transdermal permeation profile of selected analgesic drug. It is concluded that proniosomal gel can be used as a vehicle for transdermal iontophoretic drug delivery under suitable electric conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=iontophoresis" title="iontophoresis">iontophoresis</a>, <a href="https://publications.waset.org/abstracts/search?q=niosomes" title=" niosomes"> niosomes</a>, <a href="https://publications.waset.org/abstracts/search?q=permeation%20enhancement" title=" permeation enhancement"> permeation enhancement</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal%20delivery" title=" transdermal delivery"> transdermal delivery</a> </p> <a href="https://publications.waset.org/abstracts/47437/combined-effect-of-vesicular-system-and-iontophoresis-on-skin-permeation-enhancement-of-an-analgesic-drug" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47437.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">378</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">24</span> Increasing Solubility and Bioavailability of Fluvastatin through Transdermal Nanoemulsion Gel Delivery System for the Treatment of Osteoporosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ramandeep%20Kaur">Ramandeep Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Makula%20Ajitha"> Makula Ajitha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fluvastatin has been reported for increasing bone mineral density in osteoporosis since last decade. Systemically administered drug undergoes extensive hepatic first-pass metabolism, thus very small amount of drug reaches the bone tissue which is highly insignificant. The present study aims to deliver fluvastatin in the form of nanoemulsion (NE) gel directly to the bone tissue through transdermal route thereby bypassing hepatic first pass metabolism. The NE formulation consisted of isopropyl myristate as oil, tween 80 as surfactant, transcutol as co-surfactant and water as the aqueous phase. Pseudoternary phase diagrams were constructed using aqueous titration method and NE’s obtained were subjected to thermodynamic-kinetic stability studies. The stable NE formulations were evaluated for their droplet size, zeta potential, and transmission electron microscopy (TEM). The nano-sized formulations were incorporated into 0.5% carbopol 934 gel matrix. Ex-vivo permeation behaviour of selected formulations through rat skin was investigated and compared with the conventional formulations (suspension and emulsion). Further, in-vivo pharmacokinetic study was carried using male Wistar rats. The optimized NE formulations mean droplet size was 11.66±3.2 nm with polydispersity index of 0.117. Permeation flux of NE gel formulations was found significantly higher than the conventional formulations i.e. suspension and emulsion. In vivo pharmacokinetic study showed significant increase in bioavailability (1.25 fold) of fluvastatin than oral formulation. Thus, it can be concluded that NE gel was successfully developed for transdermal delivery of fluvastatin for the treatment of osteoporosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fluvastatin" title="fluvastatin">fluvastatin</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoemulsion%20gel" title=" nanoemulsion gel"> nanoemulsion gel</a>, <a href="https://publications.waset.org/abstracts/search?q=osteoporosis" title=" osteoporosis"> osteoporosis</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a> </p> <a href="https://publications.waset.org/abstracts/75669/increasing-solubility-and-bioavailability-of-fluvastatin-through-transdermal-nanoemulsion-gel-delivery-system-for-the-treatment-of-osteoporosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75669.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">189</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> In vitro Evaluation of Capsaicin Patches for Transdermal Drug Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alija%20Uzunovic">Alija Uzunovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Sasa%20Pilipovic"> Sasa Pilipovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Aida%20Sapcanin"> Aida Sapcanin</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahida%20Ademovic"> Zahida Ademovic</a>, <a href="https://publications.waset.org/abstracts/search?q=Berina%20Pilipovi%C4%87"> Berina Pilipović</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Capsaicin is a naturally occurring alkaloid extracted from capsicum fruit extracts of different of Capsicum species. It has been employed topically to treat many diseases such as rheumatoid arthritis, osteoarthritis, cancer pain and nerve pain in diabetes. The high degree of pre-systemic metabolism of intragastrical capsaicin and the short half-life of capsaicin by intravenous administration made topical application of capsaicin advantageous. In this study, we have evaluated differences in the dissolution characteristics of capsaicin patch 11 mg (purchased from market) at different dissolution rotation speed. The proposed patch area is 308 cm2 (22 cm x 14 cm; it contains 36 µg of capsaicin per square centimeter of adhesive). USP Apparatus 5 (Paddle Over Disc) is used for transdermal patch testing. The dissolution study was conducted using USP apparatus 5 (n=6), ERWEKA DT800 dissolution tester (paddle-type) with addition of a disc. The fabricated patch of 308 cm2 is to be cut into 9 cm2 was placed against a disc (delivery side up) retained with the stainless-steel screen and exposed to 500 mL of phosphate buffer solution pH 7.4. All dissolution studies were carried out at 32 ± 0.5 °C and different rotation speed (50± 5; 100± 5 and 150± 5 rpm). 5 ml aliquots of samples were withdrawn at various time intervals (1, 4, 8 and 12 hours) and replaced with 5 ml of dissolution medium. Withdrawn were appropriately diluted and analyzed by reversed-phase liquid chromatography (RP-LC). A Reversed Phase Liquid Chromatography (RP-LC) method has been developed, optimized and validated for the separation and quantitation of capsaicin in a transdermal patch. The method uses a ProntoSIL 120-3-C18 AQ 125 x 4,0 mm (3 μm) column maintained at 600C. The mobile phase consisted of acetonitrile: water (50:50 v/v), the flow rate of 0.9 mL/min, the injection volume 10 μL and the detection wavelength 222 nm. The used RP-LC method is simple, sensitive and accurate and can be applied for fast (total chromatographic run time was 4.0 minutes) and simultaneous analysis of capsaicin and dihydrocapsaicin in a transdermal patch. According to the results obtained in this study, we can conclude that the relative difference of dissolution rate of capsaicin after 12 hours was elevated by increase of dissolution rotation speed (100 rpm vs 50 rpm: 84.9± 11.3% and 150 rpm vs 100 rpm: 39.8± 8.3%). Although several apparatus and procedures (USP apparatus 5, 6, 7 and a paddle over extraction cell method) have been used to study in vitro release characteristics of transdermal patches, USP Apparatus 5 (Paddle Over Disc) could be considered as a discriminatory test. would be able to point out the differences in the dissolution rate of capsaicin at different rotation speed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=capsaicin" title="capsaicin">capsaicin</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro" title=" in vitro"> in vitro</a>, <a href="https://publications.waset.org/abstracts/search?q=patch" title=" patch"> patch</a>, <a href="https://publications.waset.org/abstracts/search?q=RP-LC" title=" RP-LC"> RP-LC</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a> </p> <a href="https://publications.waset.org/abstracts/70570/in-vitro-evaluation-of-capsaicin-patches-for-transdermal-drug-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/70570.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">227</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> Formulation and Evaluation of TDDS for Sustained Release Ondansetron HCL Patches</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Baljinder%20Singh">Baljinder Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Navneet%20Sharma"> Navneet Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The skin can be used as the site for drug administration for continuous transdermal drug infusion into the systemic circulation. For the continuous diffusion/penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed. Various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type systems, the drug is dispersed in the solvent along with the polymers and solvent allowed to evaporate forming a homogeneous drug-polymer matrix. Matrix type systems were developed in the present study. In the present work, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of ondansetron-HCl with different ratios of hydrophilic and hydrophobic polymeric combinations using solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. The patches were further subjected to various physical evaluations along with the in-vitro permeation studies using rat skin. On the basis of results obtained form the in vitro study and physical evaluation, the patches containing hydrophilic polymers i.e. polyvinyl alcohol and poly vinyl pyrrolidone with oleic acid as the penetration enhancer(5%) were considered as suitable for large scale manufacturing with a backing layer and a suitable adhesive membrane. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery" title="transdermal drug delivery">transdermal drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=penetration%20enhancers" title=" penetration enhancers"> penetration enhancers</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic%20and%20hydrophobic%20polymers" title=" hydrophilic and hydrophobic polymers"> hydrophilic and hydrophobic polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=ondansetron%20HCl" title=" ondansetron HCl"> ondansetron HCl</a> </p> <a href="https://publications.waset.org/abstracts/8874/formulation-and-evaluation-of-tdds-for-sustained-release-ondansetron-hcl-patches" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8874.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">322</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Formulation and in vitro Evaluation of Transdermal Delivery of Articaine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dinakaran%20Venkatachalam">Dinakaran Venkatachalam</a>, <a href="https://publications.waset.org/abstracts/search?q=Paul%20Chambers"> Paul Chambers</a>, <a href="https://publications.waset.org/abstracts/search?q=Kavitha%20Kongara"> Kavitha Kongara</a>, <a href="https://publications.waset.org/abstracts/search?q=Preet%20Singh"> Preet Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of this study is to formulate different topical preparations containing articaine and to investigate their permeation through goat skin. Initially, articaine and its hydrochloride salt were compared for in vitro permeation using Franz cell model. Goat skin samples were collected after euthanizing male goat kids purchased from the dairy goat farmers. Subcutaneous fat was removed and the skin was mounted on the donor chamber (orifice area 1.00 cm²) and drugs were applied onto the epidermis. Phosphate buffer saline (pH 7.4) was used to maintain sink condition in the receptor chamber (8 ml) of the Franz cell. Samples (0.4 ml) were collected at various intervals over 24 hours after each sampling equal volume of PBS was replaced in the receptor chamber. Articaine in the collected samples were quantified using LC/MS. The results suggested that articaine free base permeates better than its hydrochloride salt through goat skin. This study results support the fact that local anesthetics in its base form are lipophilic and thus penetrates faster through cell membranes than their salts. Later, articaine free base was formulated either using ethanol and octyl salicylate or dimethyl sulfoxide (DMSO) as penetration enhancers and was compared for in vitro permeation. The transdermal flux of articaine in the formulation containing DMSO was approximately 3.8 times higher than that of the formulation containing ethanol and octyl salicylate. Further studies to evaluate the local anesthetic efficacy of the topical formulation containing articaine for dermal anesthesia in animals have been planned. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=articaine" title="articaine">articaine</a>, <a href="https://publications.waset.org/abstracts/search?q=dermal%20anesthesia" title=" dermal anesthesia"> dermal anesthesia</a>, <a href="https://publications.waset.org/abstracts/search?q=local%20anesthetic" title=" local anesthetic"> local anesthetic</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal"> transdermal</a> </p> <a href="https://publications.waset.org/abstracts/80319/formulation-and-in-vitro-evaluation-of-transdermal-delivery-of-articaine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/80319.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">237</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> Oral Versus Iontophoresis Nonsteroidal Anti-Inflammatory Drugs in Tennis Elbow</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Moustafa%20Ali%20Elwan">Moustafa Ali Elwan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ibrahim%20Salem%20Abdelrafa"> Ibrahim Salem Abdelrafa</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashraf%20Moharm"> Ashraf Moharm</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed oral and topical drugs worldwide. Moreover, NSAIDs are responsible for most of all adverse drug reactions. For several decades, there are numerous attempts to use the cutaneous layers as a gate into the body for the local delivery of the therapeutic agent. Transdermal drug delivery is a validated technology contributing significantly to global pharmaceutical care. Transdermal Drug Delivery systems can be improved by using therapeutic agents. Moreover, Transdermal Drug Delivery systems can be improved by using chemical enhancers like ultrasound or iontophoresis. Iontophoresis provides a mechanism to enhance the penetration of hydrophilic and charged molecules across the skin. Objective: to compare the drug administration by ‘iontophoresis’ versus the oral rule. Methods: This study was conducted at the Faculty of Physical Therapy, Modern University for technology and information, Cairo, Egypt, on 20 participants (8 female & 12 male) who complained of tennis elbow. Their mean age was (25.45 ± 3.98) years, and all participants were assessed in many aspects: Pain threshold was assessed by algometer. Range of motion was assessed by electro goniometer, and isometric strength was assessed by a portable hand-held dynamometer. Then Participants were randomly assigned into two groups: group A was treated with oral NSAID (diclofenac) while group B was treated via administration of NSAIDs (diclofenac) via an iontophoresis device. All the participants were subjected to blood samples analysis in both pre-administration of the drug and post-administration of the drug for 24 hours (sample/every 6 hours). Results: The results demonstrated that there was a significant improvement in group b, “iontophoresis NSAIDs group,” more than in group B,” oral NSAIDs group,” in all measurements ‘ pain threshold, strength, and range of motion. Also, the iontophoresis method shows higher maximum plasma concentrations (Cmax) and concentration-time curves than the oral method. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diclofenac" title="diclofenac">diclofenac</a>, <a href="https://publications.waset.org/abstracts/search?q=iontophoresis" title=" iontophoresis"> iontophoresis</a>, <a href="https://publications.waset.org/abstracts/search?q=NSAIDs" title=" NSAIDs"> NSAIDs</a>, <a href="https://publications.waset.org/abstracts/search?q=oral" title=" oral"> oral</a>, <a href="https://publications.waset.org/abstracts/search?q=tennis%20elbow" title=" tennis elbow"> tennis elbow</a> </p> <a href="https://publications.waset.org/abstracts/155583/oral-versus-iontophoresis-nonsteroidal-anti-inflammatory-drugs-in-tennis-elbow" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/155583.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">115</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> A Randomised, Single-Dose, Two-Period, Cross-Over Phase I Pharmacokinetic Study to Compare TDS®-Diazepam with Rectal Diazepam in Healthy Adult Subjects</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Faisal%20O.%20Al-Otaibi">Faisal O. Al-Otaibi</a>, <a href="https://publications.waset.org/abstracts/search?q=Arthur%20T.%20Tucker"> Arthur T. Tucker</a>, <a href="https://publications.waset.org/abstracts/search?q=Richard%20M.%20Langford"> Richard M. Langford</a>, <a href="https://publications.waset.org/abstracts/search?q=Stuart%20Ratcliffe"> Stuart Ratcliffe</a>, <a href="https://publications.waset.org/abstracts/search?q=Atholl%0D%0AJohnston"> Atholl Johnston</a>, <a href="https://publications.waset.org/abstracts/search?q=Terry%20D.%20Lee"> Terry D. Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Kenneth%20B.%20Kirby"> Kenneth B. Kirby</a>, <a href="https://publications.waset.org/abstracts/search?q=Chandan%20A.%20Alam"> Chandan A. Alam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Transdermal Delivery System (TDS®) is a proprietary liquid formulation that can be applied to intact skin via a metered pump spray to facilitate drug delivery to the circulation. The aim of this study was to assess the ability of the TDS preparation to deliver diazepam systemically, and to characterize the pharmacokinetic profile of the drug in healthy adult subjects. We conducted a randomized, single-dose, two-period, crossover phase I (pharmacokinetic) comparative study in twelve healthy volunteers. All volunteers received both 10 mg TDS-diazepam topically to the upper chest and 10 mg of the rectal diazepam preparation (Diastat®, 10 mg diazepam gel), with a minimum washout of 14 days between dosing episodes. Both formulations were well tolerated in all volunteers. Following topical application of TDS-diazepam, the mean AUC0-72h was 1241 ng/mL.h and the Cmax 34 ng/mL. The values for rectal Diastat were 4109 ng/mL.h and 300 ng/mL respectively. This proof of concept study demonstrates that the TDS preparation successfully delivered diazepam systemically to adults. As expected, the concentration of diazepam following the TDS application was lower and not bioequivalent to rectal gel. Future development of this unique system is required. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=transdermal%20delivery%20system" title="transdermal delivery system">transdermal delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=diazepam" title=" diazepam"> diazepam</a>, <a href="https://publications.waset.org/abstracts/search?q=seizure" title=" seizure"> seizure</a>, <a href="https://publications.waset.org/abstracts/search?q=bioequivalence" title=" bioequivalence"> bioequivalence</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacokinetic" title=" pharmacokinetic"> pharmacokinetic</a> </p> <a href="https://publications.waset.org/abstracts/12728/a-randomised-single-dose-two-period-cross-over-phase-i-pharmacokinetic-study-to-compare-tds-diazepam-with-rectal-diazepam-in-healthy-adult-subjects" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12728.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">425</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> The Study of Dissolving Microneedle Patch for Androgenetic Alopecia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Li-Yu%20Lee">Li-Yu Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Shuan%20Chen"> Yu-Shuan Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jun%20Sheng%20Wang"> Jun Sheng Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=I-Ming%20Chu"> I-Ming Chu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microneedle patch is a painless transdermal drug delivery method, It could solve some problems in traditional drug delivery such as digestive system causing drug metabolism and subcutaneous injection causing some side effects. Coating drug on or loading drug in microneedle can carry active ingredient through stratum corneum, also can control dose well when microneedle patch apply on localized topical area. We used hyaluronic acid to fabricate dissolvable microneedle patch and encapsulated minoxidil into microneedles. Minoxdil is a drug for exterior use that can be used to treat Androgenetic alopecia, but related commercial products have some shortcomings, for example, propylene glycol which is used to soften stratum corneum cause skin allergic reaction, comparing chemical promotion, microneedle patch provide physical way to make drugs through nature barrier of skin. In this research, we designed a two-step process to fabricate microneedle patch, that can effectively reduce drug waste, and gentle production process could maintain drug activity well. We also do in vitro test on cadaver to make sure patch has enough mechanical strength to penetrate stratum corneum. In the release test and animal test, we found microneedle patch has higher delivery efficiency than tradition way. In this study, we may determine that germinal MNs patch is a potential commodity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dissolving%20microneedles" title="dissolving microneedles">dissolving microneedles</a>, <a href="https://publications.waset.org/abstracts/search?q=androgenetic%20alopecia" title=" androgenetic alopecia"> androgenetic alopecia</a>, <a href="https://publications.waset.org/abstracts/search?q=minoxidil" title=" minoxidil"> minoxidil</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal%20drug%20delivery" title=" transdermal drug delivery"> transdermal drug delivery</a> </p> <a href="https://publications.waset.org/abstracts/66745/the-study-of-dissolving-microneedle-patch-for-androgenetic-alopecia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66745.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">279</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> Wound Healing Dressing and Some Composites Such as Zeolite, TiO2, Chitosan and PLGA as New Alternative for Melanoma Therapy: A Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=L.%20B.%20Naves">L. B. Naves</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Almeida"> L. Almeida</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of Drugs Delivery System (DDS), has been wildly investigated in the last decades. In this paper, first a general overview of traditional and modern wound dressing is presented. This is followed by a review of what scientist have done in the medical environment, focusing the possibility to develop a new alternative for DDS through transdermal pathway, aiming to treat melanoma skin cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer%20therapy" title="cancer therapy">cancer therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=dressing%20polymers" title=" dressing polymers"> dressing polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=melanoma" title=" melanoma"> melanoma</a>, <a href="https://publications.waset.org/abstracts/search?q=wound%20healing" title=" wound healing"> wound healing</a> </p> <a href="https://publications.waset.org/abstracts/23920/wound-healing-dressing-and-some-composites-such-as-zeolite-tio2-chitosan-and-plga-as-new-alternative-for-melanoma-therapy-a-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23920.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">414</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Transdermal Delivery of Sodium Diclofenac from Palm Kernel Oil Esteres Nanoemulsions </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Malahat%20Rezaee">Malahat Rezaee</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahiran%20Basri"> Mahiran Basri</a>, <a href="https://publications.waset.org/abstracts/search?q=Abu%20Bakar%20Salleh"> Abu Bakar Salleh</a>, <a href="https://publications.waset.org/abstracts/search?q=Raja%20Noor%20Zaliha%20Raja%20Abdul%20Rahman"> Raja Noor Zaliha Raja Abdul Rahman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sodium diclofenac is one of the most commonly used drugs of nonsteroidal anti-inflammatory drugs (NSAIDs). It is especially effective in the controlling the severe conditions of inflammation and pain, musculoskeletal disorders, arthritis, and dysmenorrhea. Formulation as nanoemulsions is one of the nanoscience approaches that has been progressively considered in pharmaceutical science for transdermal delivery of the drug. Nanoemulsions are a type of emulsion with particle sizes ranging from 20 nm to 200 nm. An emulsion is formed by the dispersion of one liquid, usually the oil phase in another immiscible liquid, water phase that is stabilized using the surfactant. Palm kernel oil esters (PKOEs), in comparison to other oils, contain higher amounts of shorter chain esters, which suitable to be applied in micro and nanoemulsion systems as a carrier for actives, with excellent wetting behavior without the oily feeling. This research aimed to study the effect of terpene type and concentration on sodium diclofenac permeation from palm kernel oil esters nanoemulsions and physicochemical properties of the nanoemulsions systems. The effect of various terpenes of geraniol, menthone, menthol, cineol and nerolidol at different concentrations of 0.5, 1.0, 2.0, and 4.0% on permeation of sodium diclofenac were evaluated using Franz diffusion cells and rat skin as permeation membrane. The results of this part demonstrated that all terpenes showed promoting effect on sodium diclofenac penetration. However, menthol and menthone at all concentrations showed significant effects (<0.05) on drug permeation. The most outstanding terpene was menthol with the most significant effect for skin permeability of sodium diclofenac. The effect of terpenes on physicochemical properties of nanoemulsion systems was investigated on the parameters of particle size, zeta potential, pH, viscosity and electrical conductivity. The result showed that all terpenes had the significant effect on particle size and non-significant effects on the zeta potential of the nanoemulsion systems. The effect of terpenes was significant on pH, excluding the menthone at concentrations of 0.5 and 1.0%, and cineol and nerolidol at the concentration of 2.0%. Terpenes also had significant effect on viscosity of nanoemulsions exception of menthone and cineol at the concentration of 0.5%. The result of conductivity measurements showed that all terpenes at all concentration except cineol at the concentration of 0.5% represented significant effect on electrical conductivity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoemulsions" title="nanoemulsions">nanoemulsions</a>, <a href="https://publications.waset.org/abstracts/search?q=palm%20kernel%20oil%20esters" title=" palm kernel oil esters"> palm kernel oil esters</a>, <a href="https://publications.waset.org/abstracts/search?q=sodium%20diclofenac" title=" sodium diclofenac"> sodium diclofenac</a>, <a href="https://publications.waset.org/abstracts/search?q=terpenes" title=" terpenes"> terpenes</a>, <a href="https://publications.waset.org/abstracts/search?q=skin%20permeation" title=" skin permeation"> skin permeation</a> </p> <a href="https://publications.waset.org/abstracts/36814/transdermal-delivery-of-sodium-diclofenac-from-palm-kernel-oil-esteres-nanoemulsions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36814.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">421</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Breath Ethanol Imaging System Using Real Time Biochemical Luminescence for Evaluation of Alcohol Metabolic Capacity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xin%20Wang">Xin Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Munkbayar%20Munkhjargal"> Munkbayar Munkhjargal</a>, <a href="https://publications.waset.org/abstracts/search?q=Kumiko%20Miyajima"> Kumiko Miyajima</a>, <a href="https://publications.waset.org/abstracts/search?q=Takahiro%20Arakawa"> Takahiro Arakawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Kohji%20Mitsubayashi"> Kohji Mitsubayashi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The measurement of gaseous ethanol plays an important role of evaluation of alcohol metabolic capacity in clinical and forensic analysis. A 2-dimensional visualization system for gaseous ethanol was constructed and tested in visualization of breath and transdermal alcohol. We demonstrated breath ethanol measurement using developed high-sensitive visualization system. The concentration of breath ethanol calculated with the imaging signal was significantly different between the volunteer subjects of ALDH2 (+) and (-). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breath%20ethanol" title="breath ethanol">breath ethanol</a>, <a href="https://publications.waset.org/abstracts/search?q=ethnaol%20imaging" title=" ethnaol imaging"> ethnaol imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=biochemical%20luminescence" title=" biochemical luminescence"> biochemical luminescence</a>, <a href="https://publications.waset.org/abstracts/search?q=alcohol%20metabolism" title=" alcohol metabolism"> alcohol metabolism</a> </p> <a href="https://publications.waset.org/abstracts/2708/breath-ethanol-imaging-system-using-real-time-biochemical-luminescence-for-evaluation-of-alcohol-metabolic-capacity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2708.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">351</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Arbutin-loaded Butylglyceryl Dextran Nanoparticles for Topical Delivery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20F.%20Bostanudin">Mohammad F. Bostanudin</a>, <a href="https://publications.waset.org/abstracts/search?q=Tan%20S.%20Fei"> Tan S. Fei</a>, <a href="https://publications.waset.org/abstracts/search?q=Azwan%20M.%20Lazim"> Azwan M. Lazim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Toward the development of colloidal systems that are able to enhance permeation across the skin, a material combining the non-toxic and non-immunogenic of dextran with alkylglycerols permeation enhancing property has been designed. To this purpose, a range of butylglyceryl dextrans (DEX-OX4) were synthesized via functionalization with n-butylglycidyl ether and the successful functionalization was confirmed by NMR and FT-IR spectroscopies, along with GPC with a degree of modification in the range 6.3–35.7 %. A reduced viscosity and an increased molecular weight of DEX-OX4 were also recorded when compared to that of the native dextran. DEX-OX4 was further formulated into nanocarriers and loaded with α-arbutin prior to be investigated for their particle size, morphology, stability, loading ability, and release profiles. The resulting nanoparticles were found to be close-to-spherical and relatively stable at pH 5 and 7, with size 180–220 nm (ζ-potential -22 to -25 mV), and a loading degree of 11.7 %. Lack of toxicity at application-relevant concentrations and increased permeation across skin biological membrane model were demonstrated by nanoparticles in-vitro results against immortalized skin human keratinocytes cells (HaCaT). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=butylglycerols" title="butylglycerols">butylglycerols</a>, <a href="https://publications.waset.org/abstracts/search?q=dextran" title=" dextran"> dextran</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=transdermal" title=" transdermal "> transdermal </a> </p> <a href="https://publications.waset.org/abstracts/128722/arbutin-loaded-butylglyceryl-dextran-nanoparticles-for-topical-delivery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/128722.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">123</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Development and Characterization of Mesoporous Silica Nanoparticles of Quercetin in Skin Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khusboo%20Agrawal">Khusboo Agrawal</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Saraf"> S. Saraf</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Quercetin, a flavonol provides a cellular protection against UV induced oxidative damages due to its excellent free radical scavenging activity and direct pro-apoptopic effect on tumor cells. However, its topical use is limited due to its unfavorable physicochemical properties. The present study was aimed to evaluate the potential of mesoporous silica nanoparticles as topical carrier system for quercetin delivery. Complexes of quercetin with mesoporous silica was prepared with different weight ratios and characterized by thermo gravimetric analysis, X-ray diffraction, high resolution TEM, FT-IR spectroscopy, zeta potential measurements and differential scanning calorimetry The protective effect of this vehicle on UV-induced degradation of the quercetin was investigated revealing a certain positive inﬂuence of the inclusion on the photostability over time. Epidermal accumulation and transdermal permeation of this molecule were ex vivo evaluated by using Franz diffusion cells. The immobilization of Quercetin in mesoporous silica nanoparticles (MSNs) increased the stability without undermining the antioxidant efficacy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer" title="cancer">cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=MSNs" title=" MSNs"> MSNs</a>, <a href="https://publications.waset.org/abstracts/search?q=quercetin" title=" quercetin"> quercetin</a>, <a href="https://publications.waset.org/abstracts/search?q=topical%20delivery" title=" topical delivery"> topical delivery</a> </p> <a href="https://publications.waset.org/abstracts/47665/development-and-characterization-of-mesoporous-silica-nanoparticles-of-quercetin-in-skin-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/47665.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">308</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> The Potential of Ursolic Acid Acetate as an Agent for Malarial Chemotherapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mthokozisi%20B.%20C.%20Simelane">Mthokozisi B. C. Simelane</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Despite the various efforts by governmental and non-governmental organizations aimed at eradicating the disease, malaria is said to kill a child every 30 seconds. Traditional healers use different concoctions prepared from medicinal plants to treat malaria. In the quest to bio-prospect plant-derived triterpenes for anti-malaria activity, we report here the in vivo antiplasmodial activity of ursolic acid acetate (ursolic acid isolated from dichloromethane extract of Mimusops caffra was chemically modified to its acetate derivative). The transdermal administration of ursolic acid acetate (UAA) dose dependently showed complete inhibition of the parasites’ growth at the highest concentration of 400 mg/kg after 15 days of Plasmodium berghei infection. UAA prevented the in vitro aggregation of MDH but did not prevent the expression of PfHsp 70 in E. coli XL1 blue cells. It, however, enhanced PfHsp70 ATPase activity with the specific activity of 65 units (amount of phosphate released 73.83 nmolPi/min.mg). Ursolic acid acetate prevented the formation of hemozoin (60 ± 0.02% at 6 mg/ml). The results suggest that Ursolic acid acetate possesses potential anti-malaria properties. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mimusops%20caffra" title="Mimusops caffra">Mimusops caffra</a>, <a href="https://publications.waset.org/abstracts/search?q=ursolic%20acid%20acetate" title=" ursolic acid acetate"> ursolic acid acetate</a>, <a href="https://publications.waset.org/abstracts/search?q=hemozoin" title=" hemozoin"> hemozoin</a>, <a href="https://publications.waset.org/abstracts/search?q=Malaria" title=" Malaria"> Malaria</a> </p> <a href="https://publications.waset.org/abstracts/46821/the-potential-of-ursolic-acid-acetate-as-an-agent-for-malarial-chemotherapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/46821.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">423</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Sniff-Camera for Imaging of Ethanol Vapor in Human Body Gases after Drinking</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Toshiyuki%20Sato">Toshiyuki Sato</a>, <a href="https://publications.waset.org/abstracts/search?q=Kenta%20Iitani"> Kenta Iitani</a>, <a href="https://publications.waset.org/abstracts/search?q=Koji%20Toma"> Koji Toma</a>, <a href="https://publications.waset.org/abstracts/search?q=Takahiro%20Arakawa"> Takahiro Arakawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Kohji%20Mitsubayashi"> Kohji Mitsubayashi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A 2-dimensional imaging system (Sniff-camera) for gaseous ethanol emissions from a human palm skin was constructed and demonstrated. This imaging system measures gaseous ethanol concentrations as intensities of chemiluminescence (CL) by luminol reaction induced by alcohol oxidase and luminol-hydrogen peroxide system. A conversion of ethanol distributions and concentrations to 2-dimensional CL was conducted on an enzyme-immobilized mesh substrate in a dark box, which contained a luminol solution. In order to visualize ethanol emissions from human palm skin, we developed highly sensitive and selective imaging system for transpired gaseous ethanol at sub ppm-levels. High sensitivity imaging allows us to successfully visualize the emissions dynamics of transdermal gaseous ethanol. The intensity of each pixel on the palm shows the reflection of ethanol concentrations distributions based on the metabolism of oral alcohol administration. This imaging system is significant and useful for the assessment of ethanol measurement of the palmar skin. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sniff-camera" title="sniff-camera">sniff-camera</a>, <a href="https://publications.waset.org/abstracts/search?q=gas-imaging" title=" gas-imaging"> gas-imaging</a>, <a href="https://publications.waset.org/abstracts/search?q=ethanol%20vapor" title=" ethanol vapor"> ethanol vapor</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20body%20gas" title=" human body gas"> human body gas</a> </p> <a href="https://publications.waset.org/abstracts/31989/sniff-camera-for-imaging-of-ethanol-vapor-in-human-body-gases-after-drinking" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31989.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">369</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> The Methods of Immobilization of Laccase for Direct Transfer in an Enzymatic Fuel Cell</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Afshin%20Farahbakhsh">Afshin Farahbakhsh</a>, <a href="https://publications.waset.org/abstracts/search?q=Hoda%20Khodadadi"> Hoda Khodadadi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, we compare five methods of biological fuel cell fabrication by combining a Shewanella oneidensis microbial anode and a laccase-modified air-breathing cathode. As a result of biofuel cell laccase with graphite nanofibers, carbon surface (PAMAN) on the pt/hpg electrode, graphite sheets MWCNT and with (PG) and (MWCNT) showed, respectively. Describes methods for creating controllable and reproducible bio-anodes and demonstrates the versatility of hybrid biological fuel cells. The laccase-based biocathodes prepared either with the crude extract or with the purified enzyme can provide electrochemically active and stable biomaterials. The laccase-based biocathodes prepared either with the crude extract or with the purified enzyme can provide electrochemically active and stable biomaterials. When the device was fed with transdermal extracts, containing only 30μM of glucose, the average peak power was proportionally lower (0.004mW). The result of biofuel cell with graphite nanofibers showed the enzymatic fuel cell reaches 0.5 V at open circuit voltage with both, ethanol and methanol and the maximum current density observed for E2electrode was 228.94mAcm. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=enzymatic%20electrode" title="enzymatic electrode">enzymatic electrode</a>, <a href="https://publications.waset.org/abstracts/search?q=fuel%20cell" title=" fuel cell"> fuel cell</a>, <a href="https://publications.waset.org/abstracts/search?q=immobilization" title=" immobilization"> immobilization</a>, <a href="https://publications.waset.org/abstracts/search?q=laccase" title=" laccase"> laccase</a> </p> <a href="https://publications.waset.org/abstracts/52042/the-methods-of-immobilization-of-laccase-for-direct-transfer-in-an-enzymatic-fuel-cell" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52042.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">261</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Development and Characterization of a Film Based on Hydroxypropyl Methyl Cellulose Incorporated by a Phenolic Extract of Fennel and Reinforced by Magnesium Oxide: In Vivo - in Vitro</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mazouzi%20Nourdjihane">Mazouzi Nourdjihane</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Boutemak"> K. Boutemak</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Haddad"> A. Haddad</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Chegreouche"> Y. Chegreouche</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the last decades, biodegradable polymers have been considered as one of the most popular options for the delivery of drugs and various conventional doses. The film forming system (FFS) can be used in topical, transdermal, ophthalmic, oral and gastric applications. Recently this system has focused on improving drug delivery, which can promote drug release. In this context, the aim of this study is to create polymeric film-forming systems for the stomach and to evaluate and test their gastroprotective effects, comparing the effects of changes in composition on film characteristics. It uses a plant-derived polyphenol extract extracted from fennel to demonstrate anti-inflammatory activity in the film. The films are made from hydroxypropyl methylcellulose polymer and different types of plastic, glycerol and polyethylene glycol. The ffs properties show that MgO-glycerol-reinforced hydroxypropylmethylcellulose (HPMC-MgO-Gly) is better than that based on MgO-PEG-reinforced hydroxypropylmethylcellulose (HPMC-MgO-PEG). It is durable, has a faster drying time and allows for maximum recovery. Water vapor strength and blowing speed and other additions show another advantage of HPMC-MgO-Gly compared to HPMC-MgO-PEG, indicating good adhesion between the support (top) and film production. In this study, the gastroprotective effect of fennel phenol extract was found, showing that this plant material has a gastroprotective effect on ulcers and that the film can absorb the active substance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=film%20formin%20system" title="film formin system">film formin system</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxypropyl%20methylcellulose" title=" hydroxypropyl methylcellulose"> hydroxypropyl methylcellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=magnesium%20oxide" title=" magnesium oxide"> magnesium oxide</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vivo" title=" in vivo"> in vivo</a> </p> <a href="https://publications.waset.org/abstracts/180998/development-and-characterization-of-a-film-based-on-hydroxypropyl-methyl-cellulose-incorporated-by-a-phenolic-extract-of-fennel-and-reinforced-by-magnesium-oxide-in-vivo-in-vitro" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/180998.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">66</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Hybrid-Nanoengineering™: A New Platform for Nanomedicine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mewa%20Singh">Mewa Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanomedicine, a fusion of nanotechnology and medicine, is an emerging technology ideally suited to the targeted therapies. Nanoparticles overcome the low selectivity of anti-cancer drugs toward the tumor as compared to normal tissue and hence result-in less severe side-effects. Our new technology, HYBRID-NANOENGINEERING™, uses a new molecule (MR007) in the creation of nanoparticles that not only helps in nanonizing the medicine but also provides synergy to the medicine. The simplified manufacturing process will result in reduced manufacturing costs. Treatment is made more convenient because hybrid nanomedicines can be produced in oral, injectable or transdermal formulations. The manufacturing process uses no protein, oil or detergents. The particle size is below 180 nm with a narrow distribution of size. Importantly, these properties confer great stability of the structure. The formulation does not aggregate in plasma and is stable over a wide range of pH. The final hybrid formulation is stable for at least 18 months as a powder. More than 97 drugs, including paclitaxel, docetaxel, tamoxifen, doxorubicinm prednisone, and artemisinin have been nanonized in water soluble formulations. Preclinical studies on cell cultures of tumors show promising results. Our HYBRID-NANOENGINEERING™ platform enables the design and development of hybrid nano-pharmaceuticals that combine efficacy with tolerability, giving patients hope for both extended overall survival and improved quality of life. This study would discuss or present this new discovery of HYBRID-NANOENGINEERING™ which targets drug delivery, synergistic, and potentiating effects, and barriers of drug delivery and advanced drug delivery systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nano-medicine" title="nano-medicine">nano-medicine</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-particles" title=" nano-particles"> nano-particles</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery%20system" title=" drug delivery system"> drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmaceuticals" title=" pharmaceuticals"> pharmaceuticals</a> </p> <a href="https://publications.waset.org/abstracts/2323/hybrid-nanoengineering-a-new-platform-for-nanomedicine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2323.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">486</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Efficacy and Safety of Electrical Vestibular Stimulation on Adults with Symptoms of Insomnia: A Double-Blind, Randomized, Sham-Controlled Trial</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Teris%20Cheung">Teris Cheung</a>, <a href="https://publications.waset.org/abstracts/search?q=Joyce%20Yuen%20Ting%20Lam"> Joyce Yuen Ting Lam</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwan%20Hin%20Fong"> Kwan Hin Fong</a>, <a href="https://publications.waset.org/abstracts/search?q=Calvin%20Pak-Wing%20Cheng"> Calvin Pak-Wing Cheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Julie%20Sittlington"> Julie Sittlington</a>, <a href="https://publications.waset.org/abstracts/search?q=Yu-Tao%20Xiang"> Yu-Tao Xiang</a>, <a href="https://publications.waset.org/abstracts/search?q=Tim%20Man%20Ho%20Li"> Tim Man Ho Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Insomnia is one of the most common health problems in the general population. Insomnia can be acute, intermittent, and become chronic, often due to comorbidity with other physical and mental health conditions. Although there are conventional pharmaceutical and psychotherapeutic treatments to treat symptoms of insomnia, however; there is no robust and novel randomized controlled trial (RCT) using transdermal neurostimulation on individuals with insomnia symptoms. This gives us the impetus to execute the first nationwide RCT. Aim: To evaluate the efficacy of Electrical Vestibular Stimulation (VeNS) on individuals with insomnia in Hong Kong. Design: This study was a two-armed, double blinded, randomized, sham-controlled trial. Sampling: 60 community-dwelling adults aged 18 and 60 years with moderate insomnia symptoms or above (Insomnia Severity Index > 14) were recruited. All subjects were computerized randomized into either the active VeNS group or the sham VeNS group on a 1:1 ratio. Intervention: All participants received a home-use VeNS device and used 30-min VeNS sessions during five consecutive days across a 4-week period (total treatment hours: 10). Baseline measurements and post-VeNS evaluation of the psychological outcomes, including 1) insomnia severity, 2) sleep quality, and 3) quality of life were investigated. The short-and long-term sustainability of the VeNS intervention was assessed immediately after poststim and at a 1-month and 3-month follow-up period. Data analysis: A mixed GEE model was used to analyze the repeated measures data. Missing data were managed by multiple imputations. The level of significance was set to p < 0.05. Significance of the study: This is the first trial to examine the efficacy and safety of VeNS among adults with insomnia symptoms in Hong Kong. Findings that emerged were used to determine whether this VeNS device can be considered a self-help technological device to reduce the severity of insomnia in the community setting and to reduce the global disease burden. Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT04452981. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=adults" title="adults">adults</a>, <a href="https://publications.waset.org/abstracts/search?q=insomnia" title=" insomnia"> insomnia</a>, <a href="https://publications.waset.org/abstracts/search?q=neuromodulation" title=" neuromodulation"> neuromodulation</a>, <a href="https://publications.waset.org/abstracts/search?q=rct" title=" rct"> rct</a>, <a href="https://publications.waset.org/abstracts/search?q=vestibular%20stimulation" title=" vestibular stimulation"> vestibular stimulation</a> </p> <a href="https://publications.waset.org/abstracts/163984/efficacy-and-safety-of-electrical-vestibular-stimulation-on-adults-with-symptoms-of-insomnia-a-double-blind-randomized-sham-controlled-trial" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163984.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">82</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=transdermal&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=transdermal&page=2" rel="next">&rsaquo;</a></li> </ul> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a 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