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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Shashi Bhushan</h3></div><div class="js-work-strip profile--work_container" data-work-id="14865035"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865035/Capsaicin_production_by_Alternaria_alternata_an_endophytic_fungus_from_Capsicum_annum_LC_ESI_MS_MS_analysis"><img alt="Research paper thumbnail of Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/43830868/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865035/Capsaicin_production_by_Alternaria_alternata_an_endophytic_fungus_from_Capsicum_annum_LC_ESI_MS_MS_analysis">Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alternaria alternata Capsaicin Alternariol-10-methyl ether (MRM)-LC–ESI–MS/MS Anti-cancer a b s t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alternaria alternata Capsaicin Alternariol-10-methyl ether (MRM)-LC–ESI–MS/MS Anti-cancer a b s t r a c t Alternaria alternata, an endophytic fungus capable of producing capsaicin (1) was isolated from Capsicum annum. The endophyte was found to produce capsaicin upto three generations. Upscaling of the fermen-tation broth led to the isolation of one known and one compound characterized as 2,4-di-tert-butyl phenol (2) and alternariol-10-methyl ether (3) respectively. Compound 1 and 3 were identified and quan-tified using liquid chromatography-electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS) system through multiple reaction monitoring (MRM). Furthermore, compound 3 displayed a range of cytotoxicity against a panel of human cancer cell lines and was found to induce apoptosis evidenced by Hoechst staining and loss of mitochondrial-membrane potential in HL-60 cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4611fd3ede4b80aca8cba6f068896717" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830868,"asset_id":14865035,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830868/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865035"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865035"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865035; 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WO2014170914 A1" class="work-thumbnail" src="https://attachments.academia-assets.com/43830843/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865034/Cyclin_dependent_kinase_inhibition_by_5_7_dihydroxy_8_3_hydroxy_1_methylpiperidin_4_yl_2_methyl_4H_chromen_4_one_analogs_WO2014170914_A1">Cyclin-dependent kinase inhibition by 5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one analogs. WO2014170914 A1</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b6bb2a55cafa5512a723b4234a986b8a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830843,"asset_id":14865034,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830843/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865034"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865034"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865034; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865034]").text(description); $(".js-view-count[data-work-id=14865034]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865034; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865034']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b6bb2a55cafa5512a723b4234a986b8a" } } $('.js-work-strip[data-work-id=14865034]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865034,"title":"Cyclin-dependent kinase inhibition by 5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one analogs. WO2014170914 A1","internal_url":"https://www.academia.edu/14865034/Cyclin_dependent_kinase_inhibition_by_5_7_dihydroxy_8_3_hydroxy_1_methylpiperidin_4_yl_2_methyl_4H_chromen_4_one_analogs_WO2014170914_A1","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[{"id":43830843,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43830843/thumbnails/1.jpg","file_name":"Cyclin-dependent_kinase_inhibition_by_5720160317-12140-1yqo8uh.pdf","download_url":"https://www.academia.edu/attachments/43830843/download_file","bulk_download_file_name":"Cyclin_dependent_kinase_inhibition_by_5.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43830843/Cyclin-dependent_kinase_inhibition_by_5720160317-12140-1yqo8uh-libre.pdf?1458245010=\u0026response-content-disposition=attachment%3B+filename%3DCyclin_dependent_kinase_inhibition_by_5.pdf\u0026Expires=1740013949\u0026Signature=JsaNPAduEtymxkTx~BBla9sYHKUIzKcs07REb9KqyxbG4sDu2gzPotN8OPMtiv-JjFP52Rq0TEfojLVmJvXY4wGVMiBJm6yN2vH10VzZ7IbB904XS4mDGPdIx4ncj8xHQikSh4~nVMgTgsMDkh0SVAzUtF8ZhAQ0qp7sYoIQIm4uHoOqBFrPB9p6Ljk6kko5mBBWowBEs1WglRK9jQ9mEWxfY6YiN1mNCOqSIJVw~uB~4vWwkQRu4YrJDgJ9khCFeWr1KLYEn97l0EMPPV5WV6E1~673Lpt0jFaj7gtAOblm7jmtiqjpoOe52VI0SdsZ2wgmVXgRCERp6rVf2h1zzA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865033"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865033/Structural_Basis_for_Translational_Stalling_by_Human_Cytomegalovirus_and_Fungal_Arginine_Attenuator_Peptide"><img alt="Research paper thumbnail of Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide" class="work-thumbnail" src="https://attachments.academia-assets.com/43830865/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865033/Structural_Basis_for_Translational_Stalling_by_Human_Cytomegalovirus_and_Fungal_Arginine_Attenuator_Peptide">Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide</a></div><div class="wp-workCard_item"><span>Molecular Cell</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Specific regulatory nascent chains establish direct interactions with the ribosomal tunnel, leadi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Specific regulatory nascent chains establish direct interactions with the ribosomal tunnel, leading to translational stalling. Despite a wealth of biochemical data, structural insight into the mechanism of translational stalling in eukaryotes is still lacking. Here we use cryo-electron microscopy to visualize eukaryotic ribosomes stalled during the translation of two diverse regulatory peptides: the fungal arginine attenuator peptide (AAP) and the human cytomegalovirus (hCMV) gp48 upstream open reading frame 2 (uORF2). The C terminus of the AAP appears to be compacted adjacent to the peptidyl transferase center (PTC). Both nascent chains interact with ribosomal proteins L4 and L17 at tunnel constriction in a distinct fashion. Significant changes at the PTC were observed: the eukaryotic-specific loop of ribosomal protein L10e establishes direct contact with the CCA end of the peptidyl-tRNA (P-tRNA), which may be critical for silencing of the PTC during translational stalling. Our findings provide direct structural insight into two distinct eukaryotic stalling processes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e683d66f919ab0050caea690d4937994" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830865,"asset_id":14865033,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830865/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865033"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865033"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865033; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865033]").text(description); $(".js-view-count[data-work-id=14865033]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865033; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865033']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e683d66f919ab0050caea690d4937994" } } $('.js-work-strip[data-work-id=14865033]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865033,"title":"Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide","internal_url":"https://www.academia.edu/14865033/Structural_Basis_for_Translational_Stalling_by_Human_Cytomegalovirus_and_Fungal_Arginine_Attenuator_Peptide","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[{"id":43830865,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43830865/thumbnails/1.jpg","file_name":"Structural_Basis_for_Translational_Stall20160317-4369-1ll19gn.pdf","download_url":"https://www.academia.edu/attachments/43830865/download_file","bulk_download_file_name":"Structural_Basis_for_Translational_Stall.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43830865/Structural_Basis_for_Translational_Stall20160317-4369-1ll19gn-libre.pdf?1458245008=\u0026response-content-disposition=attachment%3B+filename%3DStructural_Basis_for_Translational_Stall.pdf\u0026Expires=1740013949\u0026Signature=FEx4Svor39ledDLRHlO~1jINiM4Pgv6UPnz3hMzNqA94am6GzrgcDDRBj~V9kFpATj43VE47TqnXkpZCQ8qrpuD6G6yrCLBVfMjBIWY3hVTvYAyIhX7uZC4wAD0GSFeXzxsYRXVlP8lPegO8ezLxEiQLJyU5hl-LjqrmxIllJp0IyDo8FSpijMs7sIuSAl7MeAm7fO6Ri2axSJuwvqfPAehaQZeiagsDe-JfzswNR1EGJcT6G5YMY4oXBAErqENquX9mnjBJMjR29mp7cY8B4erpQTIa6T7gL6Gd1HKI-alBbZnebIs6my2FL5zKFPp5LheOFl~AiMJ9fIAp6dc7-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865032"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865032/Identification_of_Key_Nodes_of_Type_2_Diabetes_Mellitus_Protein_Interactome_and_Study_of_their_Interactions_with_Phloridzin"><img alt="Research paper thumbnail of Identification of Key Nodes of Type 2 Diabetes Mellitus Protein Interactome and Study of their Interactions with Phloridzin" class="work-thumbnail" src="https://attachments.academia-assets.com/43830849/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865032/Identification_of_Key_Nodes_of_Type_2_Diabetes_Mellitus_Protein_Interactome_and_Study_of_their_Interactions_with_Phloridzin">Identification of Key Nodes of Type 2 Diabetes Mellitus Protein Interactome and Study of their Interactions with Phloridzin</a></div><div class="wp-workCard_item"><span>Omics: a journal of integrative biology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Network biology-inspired approaches could be used effectively in probing regulatory proc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Network biology-inspired approaches could be used effectively in probing regulatory processes by which small molecules intervene with disease mechanisms. The present study aims at identification of key targets of type 2 diabetes mellitus (T2DM) by network analysis of the underlying protein interactome, and probing for mechanisms by which phloridzin could be critical at altering the disease phenotype. Towards this goal, we constructed a protein-protein interaction network associated with T2DM, starting from candidate genes and systems-level interactions data available. The relevance of the network constructed was verified with the help of gene ontology, node deletion, and biological essentiality studies. Using a network analysis method, MAPK1, EP300, and SMAD2 were identified as the most central proteins of potential therapeutic value. Phloridzin, a known antidiabetic agent, potentially interacts with proteins central to T2DM mechanisms. The structural understanding of inter...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a4d4c234118b37328d8a384bf2a0bc07" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830849,"asset_id":14865032,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830849/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865032"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865032"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865032; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865032]").text(description); $(".js-view-count[data-work-id=14865032]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865032; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865032']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a4d4c234118b37328d8a384bf2a0bc07" } } $('.js-work-strip[data-work-id=14865032]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865032,"title":"Identification of Key Nodes of Type 2 Diabetes Mellitus Protein Interactome and Study of their Interactions with Phloridzin","internal_url":"https://www.academia.edu/14865032/Identification_of_Key_Nodes_of_Type_2_Diabetes_Mellitus_Protein_Interactome_and_Study_of_their_Interactions_with_Phloridzin","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[{"id":43830849,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43830849/thumbnails/1.jpg","file_name":"Identification_of_Key_Nodes_of_Type_2_Di20160317-11584-1knl093.pdf","download_url":"https://www.academia.edu/attachments/43830849/download_file","bulk_download_file_name":"Identification_of_Key_Nodes_of_Type_2_Di.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43830849/Identification_of_Key_Nodes_of_Type_2_Di20160317-11584-1knl093-libre.pdf?1458245009=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_Key_Nodes_of_Type_2_Di.pdf\u0026Expires=1740013949\u0026Signature=VibLUK9WtA2JAQCB1LbZG5Hs2zR1JRp8fPeoQoJRNHGhqUo7ICiVIseUOCmcBQ0j7D67oOj3XLecwTxsAmfeMh4GXvE~e2FeEDZ02RiYqXG~ClUYl5c9lppl72V1lf7x0dvTUS8g48QfKYrEVNuPanTFLU~eFQT5zpxX7arcaXWQ-waqca~fAyKYDGCQJreP0quCYFaI6axZ~ovPwbfesbeVtlPuAexBFf5OUhfCx5Wn7kh0EDAImXOJZamgyb1cPeddh52b1E5VvkG1mPt9nH5PpT6i6dkLK9uz3zZ~BjjhKx6FqkRpepNLN9gXMGkhSCeV-6hK9kIaYbMqhXhl3g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865031"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14865031/Arabinan_Type_Polysaccharides_from_Industrial_Apple_Pomace_Waste"><img alt="Research paper thumbnail of Arabinan-Type Polysaccharides from Industrial Apple Pomace Waste" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14865031/Arabinan_Type_Polysaccharides_from_Industrial_Apple_Pomace_Waste">Arabinan-Type Polysaccharides from Industrial Apple Pomace Waste</a></div><div class="wp-workCard_item"><span>Chemistry of Natural Compounds</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chemical investigation of industrial apple pomace waste has led to the isolation of two water-sol...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chemical investigation of industrial apple pomace waste has led to the isolation of two water-soluble polysaccharides (AS-3 and AS-5). Both polysaccharides were identified as arabinans on the basis of GC-MS, IR, 1D, 2D NMR, and MALDI-TOF-MS studies. GC-MS analysis of alditol acetate derivatives of AS-3 suggested the presence of arabinose and glucose sugars in the ratio of 4:1, whereas AS-5 was composed of only arabinose. The structure of AS-3 was identified as circular with three arabinose and one glucose in the circle and one arabinose unit branched at the C-4 position of the arabinose. AS-5 consists of four arabinose units, out of which three were linked linearly through 1 → 5 and 1 → 3 linkage and one in the side chain linked through 1 → 2 linkage.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865031"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865031"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865031; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865031]").text(description); $(".js-view-count[data-work-id=14865031]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865031; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865031']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14865031]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865031,"title":"Arabinan-Type Polysaccharides from Industrial Apple Pomace Waste","internal_url":"https://www.academia.edu/14865031/Arabinan_Type_Polysaccharides_from_Industrial_Apple_Pomace_Waste","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14865030/585_The_synthetic_Tryptanthrin_analogue_suppresses_STATs_signalling_and_induces_caspase_dependent_apoptosis_via_ERK_up_regulation_in_human_leukemia_HL_60_cells"><img alt="Research paper thumbnail of 585: The synthetic Tryptanthrin analogue suppresses STATs signalling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14865030/585_The_synthetic_Tryptanthrin_analogue_suppresses_STATs_signalling_and_induces_caspase_dependent_apoptosis_via_ERK_up_regulation_in_human_leukemia_HL_60_cells">585: The synthetic Tryptanthrin analogue suppresses STATs signalling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells</a></div><div class="wp-workCard_item"><span>European Journal of Cancer</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865030]").text(description); $(".js-view-count[data-work-id=14865030]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865030']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14865030]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865030,"title":"585: The synthetic Tryptanthrin analogue suppresses STATs signalling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells","internal_url":"https://www.academia.edu/14865030/585_The_synthetic_Tryptanthrin_analogue_suppresses_STATs_signalling_and_induces_caspase_dependent_apoptosis_via_ERK_up_regulation_in_human_leukemia_HL_60_cells","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865029"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865029/Autophagy_triggered_by_magnolol_derivative_negatively_regulates_angiogenesis"><img alt="Research paper thumbnail of Autophagy triggered by magnolol derivative negatively regulates angiogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/43830857/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865029/Autophagy_triggered_by_magnolol_derivative_negatively_regulates_angiogenesis">Autophagy triggered by magnolol derivative negatively regulates angiogenesis</a></div><div class="wp-workCard_item"><span>Cell Death and Disease</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Angiogenesis has a key role in the tumor progression and metastasis; targeting endothelial cell p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Angiogenesis has a key role in the tumor progression and metastasis; targeting endothelial cell proliferation has emerged as a promising therapeutic strategy for the prevention of cancer. Previous studies have revealed a complex association between the process of angiogenesis and autophagy and its outcome on tumorigenesis. Autophagy, also known as type-II cell death, has been identified as an alternative way of cell killing in apoptotic-resistant cancer cells. However, its involvement in chemoresistance and tumor promotion is also well known. In this study, we used a derivate of natural product magnolol (Ery5), a potent autophagy inducer, to study the association between the autophagy and angiogenesis in both in vitro and in vivo model system. We found that the robust autophagy triggered by Ery5, inhibited angiogenesis and caused cell death independent of the apoptosis in human umbilical cord vein endothelial cells and PC-3 cells. Ery5 induced autophagy effectively inhibited cell proliferation, migration, invasion and tube formation. We further demonstrated that Ery5-mediated autophagy and subsequent inhibition of angiogenesis was reversed when autophagy was inhibited through 3-methyl adenine and knocking down of key autophagy proteins ATG7 and microtubule-associated protein light chain 3. While evaluating the negative regulation of autophagy on angiogenesis, it was interesting to find that angiogenic environment produced by the treatment of VEGF and CoCl2 remarkably downregulated the autophagy and autophagic cell death induced by Ery5. These studies, while disclosing the vital role of autophagy in the regulation of angiogenesis, also suggest that the potent modulators of autophagy can lead to the development of effective therapeutics in apoptosis-resistant cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="955aeb6d59d24dbcc443eb0caa296fc1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830857,"asset_id":14865029,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830857/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865029"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865029"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865029; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865029]").text(description); $(".js-view-count[data-work-id=14865029]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865029; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865029']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "955aeb6d59d24dbcc443eb0caa296fc1" } } $('.js-work-strip[data-work-id=14865029]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865029,"title":"Autophagy triggered by magnolol derivative negatively regulates angiogenesis","internal_url":"https://www.academia.edu/14865029/Autophagy_triggered_by_magnolol_derivative_negatively_regulates_angiogenesis","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[{"id":43830857,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43830857/thumbnails/1.jpg","file_name":"Autophagy_triggered_by_magnolol_derivati20160317-27665-vawphx.pdf","download_url":"https://www.academia.edu/attachments/43830857/download_file","bulk_download_file_name":"Autophagy_triggered_by_magnolol_derivati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43830857/Autophagy_triggered_by_magnolol_derivati20160317-27665-vawphx-libre.pdf?1458245010=\u0026response-content-disposition=attachment%3B+filename%3DAutophagy_triggered_by_magnolol_derivati.pdf\u0026Expires=1740013949\u0026Signature=JftWos9Z7i7Ag-T5D0Ihm54t9OkBH~T2rPg8tZlDcFOPcncTv~Oquf84YBI6TY-JS5JOiCMFAQnKHWojrGIXn6ClFYxgoDI8kNQCvp6NXvL1eScJ5-1DRP~P1eShj76XWbV0JOIVov7t~7bitHNdeMNpdS-psIl2LmeLoJXChLK0uGnmH1EqQLgzXmfdgPtdAbFUOyQ9gsVKqfQ33iimvLxTkvdbXkr4owCx2KKmuRWlV4ziltnt~lXoTd5ijSsH8SOpFyn8dIIGMTjQZpUERNxvwdHAla8Sh0oBKXzdIllx54D7l4IWSRZWLLnLeKvSuKsFTuVaWRk~l8z6-VfAkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865028"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865028/Characterization_of_a_novel_zinc_metalloprotease_involved_in_degrading_targeting_peptides_in_mitochondria_and_chloroplasts"><img alt="Research paper thumbnail of Characterization of a novel zinc metalloprotease involved in degrading targeting peptides in mitochondria and chloroplasts" class="work-thumbnail" src="https://attachments.academia-assets.com/43830846/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865028/Characterization_of_a_novel_zinc_metalloprotease_involved_in_degrading_targeting_peptides_in_mitochondria_and_chloroplasts">Characterization of a novel zinc metalloprotease involved in degrading targeting peptides in mitochondria and chloroplasts</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Both authors contributed equally to this work.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f522cfe688c973effe06ebefa13353ba" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830846,"asset_id":14865028,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830846/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865028"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865028"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865028; 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LC–ESI–MS/MS analysis" class="work-thumbnail" src="https://attachments.academia-assets.com/43830868/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865035/Capsaicin_production_by_Alternaria_alternata_an_endophytic_fungus_from_Capsicum_annum_LC_ESI_MS_MS_analysis">Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Alternaria alternata Capsaicin Alternariol-10-methyl ether (MRM)-LC–ESI–MS/MS Anti-cancer a b s t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Alternaria alternata Capsaicin Alternariol-10-methyl ether (MRM)-LC–ESI–MS/MS Anti-cancer a b s t r a c t Alternaria alternata, an endophytic fungus capable of producing capsaicin (1) was isolated from Capsicum annum. The endophyte was found to produce capsaicin upto three generations. Upscaling of the fermen-tation broth led to the isolation of one known and one compound characterized as 2,4-di-tert-butyl phenol (2) and alternariol-10-methyl ether (3) respectively. Compound 1 and 3 were identified and quan-tified using liquid chromatography-electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS) system through multiple reaction monitoring (MRM). Furthermore, compound 3 displayed a range of cytotoxicity against a panel of human cancer cell lines and was found to induce apoptosis evidenced by Hoechst staining and loss of mitochondrial-membrane potential in HL-60 cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4611fd3ede4b80aca8cba6f068896717" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830868,"asset_id":14865035,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830868/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865035"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865035"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865035; 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WO2014170914 A1" class="work-thumbnail" src="https://attachments.academia-assets.com/43830843/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865034/Cyclin_dependent_kinase_inhibition_by_5_7_dihydroxy_8_3_hydroxy_1_methylpiperidin_4_yl_2_methyl_4H_chromen_4_one_analogs_WO2014170914_A1">Cyclin-dependent kinase inhibition by 5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one analogs. WO2014170914 A1</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b6bb2a55cafa5512a723b4234a986b8a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830843,"asset_id":14865034,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830843/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865034"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865034"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865034; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865034]").text(description); $(".js-view-count[data-work-id=14865034]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865034; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865034']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b6bb2a55cafa5512a723b4234a986b8a" } } $('.js-work-strip[data-work-id=14865034]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865034,"title":"Cyclin-dependent kinase inhibition by 5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one analogs. WO2014170914 A1","internal_url":"https://www.academia.edu/14865034/Cyclin_dependent_kinase_inhibition_by_5_7_dihydroxy_8_3_hydroxy_1_methylpiperidin_4_yl_2_methyl_4H_chromen_4_one_analogs_WO2014170914_A1","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[{"id":43830843,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43830843/thumbnails/1.jpg","file_name":"Cyclin-dependent_kinase_inhibition_by_5720160317-12140-1yqo8uh.pdf","download_url":"https://www.academia.edu/attachments/43830843/download_file","bulk_download_file_name":"Cyclin_dependent_kinase_inhibition_by_5.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43830843/Cyclin-dependent_kinase_inhibition_by_5720160317-12140-1yqo8uh-libre.pdf?1458245010=\u0026response-content-disposition=attachment%3B+filename%3DCyclin_dependent_kinase_inhibition_by_5.pdf\u0026Expires=1740013949\u0026Signature=JsaNPAduEtymxkTx~BBla9sYHKUIzKcs07REb9KqyxbG4sDu2gzPotN8OPMtiv-JjFP52Rq0TEfojLVmJvXY4wGVMiBJm6yN2vH10VzZ7IbB904XS4mDGPdIx4ncj8xHQikSh4~nVMgTgsMDkh0SVAzUtF8ZhAQ0qp7sYoIQIm4uHoOqBFrPB9p6Ljk6kko5mBBWowBEs1WglRK9jQ9mEWxfY6YiN1mNCOqSIJVw~uB~4vWwkQRu4YrJDgJ9khCFeWr1KLYEn97l0EMPPV5WV6E1~673Lpt0jFaj7gtAOblm7jmtiqjpoOe52VI0SdsZ2wgmVXgRCERp6rVf2h1zzA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865033"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865033/Structural_Basis_for_Translational_Stalling_by_Human_Cytomegalovirus_and_Fungal_Arginine_Attenuator_Peptide"><img alt="Research paper thumbnail of Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide" class="work-thumbnail" src="https://attachments.academia-assets.com/43830865/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865033/Structural_Basis_for_Translational_Stalling_by_Human_Cytomegalovirus_and_Fungal_Arginine_Attenuator_Peptide">Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide</a></div><div class="wp-workCard_item"><span>Molecular Cell</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Specific regulatory nascent chains establish direct interactions with the ribosomal tunnel, leadi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Specific regulatory nascent chains establish direct interactions with the ribosomal tunnel, leading to translational stalling. Despite a wealth of biochemical data, structural insight into the mechanism of translational stalling in eukaryotes is still lacking. Here we use cryo-electron microscopy to visualize eukaryotic ribosomes stalled during the translation of two diverse regulatory peptides: the fungal arginine attenuator peptide (AAP) and the human cytomegalovirus (hCMV) gp48 upstream open reading frame 2 (uORF2). The C terminus of the AAP appears to be compacted adjacent to the peptidyl transferase center (PTC). Both nascent chains interact with ribosomal proteins L4 and L17 at tunnel constriction in a distinct fashion. Significant changes at the PTC were observed: the eukaryotic-specific loop of ribosomal protein L10e establishes direct contact with the CCA end of the peptidyl-tRNA (P-tRNA), which may be critical for silencing of the PTC during translational stalling. Our findings provide direct structural insight into two distinct eukaryotic stalling processes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e683d66f919ab0050caea690d4937994" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830865,"asset_id":14865033,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830865/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865033"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865033"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865033; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865033]").text(description); $(".js-view-count[data-work-id=14865033]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865033; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865033']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865032"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865032/Identification_of_Key_Nodes_of_Type_2_Diabetes_Mellitus_Protein_Interactome_and_Study_of_their_Interactions_with_Phloridzin"><img alt="Research paper thumbnail of Identification of Key Nodes of Type 2 Diabetes Mellitus Protein Interactome and Study of their Interactions with Phloridzin" class="work-thumbnail" src="https://attachments.academia-assets.com/43830849/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865032/Identification_of_Key_Nodes_of_Type_2_Diabetes_Mellitus_Protein_Interactome_and_Study_of_their_Interactions_with_Phloridzin">Identification of Key Nodes of Type 2 Diabetes Mellitus Protein Interactome and Study of their Interactions with Phloridzin</a></div><div class="wp-workCard_item"><span>Omics: a journal of integrative biology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract Network biology-inspired approaches could be used effectively in probing regulatory proc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract Network biology-inspired approaches could be used effectively in probing regulatory processes by which small molecules intervene with disease mechanisms. The present study aims at identification of key targets of type 2 diabetes mellitus (T2DM) by network analysis of the underlying protein interactome, and probing for mechanisms by which phloridzin could be critical at altering the disease phenotype. Towards this goal, we constructed a protein-protein interaction network associated with T2DM, starting from candidate genes and systems-level interactions data available. The relevance of the network constructed was verified with the help of gene ontology, node deletion, and biological essentiality studies. Using a network analysis method, MAPK1, EP300, and SMAD2 were identified as the most central proteins of potential therapeutic value. Phloridzin, a known antidiabetic agent, potentially interacts with proteins central to T2DM mechanisms. The structural understanding of inter...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a4d4c234118b37328d8a384bf2a0bc07" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830849,"asset_id":14865032,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830849/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865032"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865032"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865032; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865032]").text(description); $(".js-view-count[data-work-id=14865032]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865032; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865032']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a4d4c234118b37328d8a384bf2a0bc07" } } $('.js-work-strip[data-work-id=14865032]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865032,"title":"Identification of Key Nodes of Type 2 Diabetes Mellitus Protein Interactome and Study of their Interactions with Phloridzin","internal_url":"https://www.academia.edu/14865032/Identification_of_Key_Nodes_of_Type_2_Diabetes_Mellitus_Protein_Interactome_and_Study_of_their_Interactions_with_Phloridzin","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[{"id":43830849,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43830849/thumbnails/1.jpg","file_name":"Identification_of_Key_Nodes_of_Type_2_Di20160317-11584-1knl093.pdf","download_url":"https://www.academia.edu/attachments/43830849/download_file","bulk_download_file_name":"Identification_of_Key_Nodes_of_Type_2_Di.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43830849/Identification_of_Key_Nodes_of_Type_2_Di20160317-11584-1knl093-libre.pdf?1458245009=\u0026response-content-disposition=attachment%3B+filename%3DIdentification_of_Key_Nodes_of_Type_2_Di.pdf\u0026Expires=1740013949\u0026Signature=VibLUK9WtA2JAQCB1LbZG5Hs2zR1JRp8fPeoQoJRNHGhqUo7ICiVIseUOCmcBQ0j7D67oOj3XLecwTxsAmfeMh4GXvE~e2FeEDZ02RiYqXG~ClUYl5c9lppl72V1lf7x0dvTUS8g48QfKYrEVNuPanTFLU~eFQT5zpxX7arcaXWQ-waqca~fAyKYDGCQJreP0quCYFaI6axZ~ovPwbfesbeVtlPuAexBFf5OUhfCx5Wn7kh0EDAImXOJZamgyb1cPeddh52b1E5VvkG1mPt9nH5PpT6i6dkLK9uz3zZ~BjjhKx6FqkRpepNLN9gXMGkhSCeV-6hK9kIaYbMqhXhl3g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865031"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14865031/Arabinan_Type_Polysaccharides_from_Industrial_Apple_Pomace_Waste"><img alt="Research paper thumbnail of Arabinan-Type Polysaccharides from Industrial Apple Pomace Waste" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14865031/Arabinan_Type_Polysaccharides_from_Industrial_Apple_Pomace_Waste">Arabinan-Type Polysaccharides from Industrial Apple Pomace Waste</a></div><div class="wp-workCard_item"><span>Chemistry of Natural Compounds</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chemical investigation of industrial apple pomace waste has led to the isolation of two water-sol...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chemical investigation of industrial apple pomace waste has led to the isolation of two water-soluble polysaccharides (AS-3 and AS-5). Both polysaccharides were identified as arabinans on the basis of GC-MS, IR, 1D, 2D NMR, and MALDI-TOF-MS studies. GC-MS analysis of alditol acetate derivatives of AS-3 suggested the presence of arabinose and glucose sugars in the ratio of 4:1, whereas AS-5 was composed of only arabinose. The structure of AS-3 was identified as circular with three arabinose and one glucose in the circle and one arabinose unit branched at the C-4 position of the arabinose. AS-5 consists of four arabinose units, out of which three were linked linearly through 1 → 5 and 1 → 3 linkage and one in the side chain linked through 1 → 2 linkage.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865031"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865031"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865031; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865031]").text(description); $(".js-view-count[data-work-id=14865031]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865031; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865031']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14865031]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865031,"title":"Arabinan-Type Polysaccharides from Industrial Apple Pomace Waste","internal_url":"https://www.academia.edu/14865031/Arabinan_Type_Polysaccharides_from_Industrial_Apple_Pomace_Waste","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865030"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/14865030/585_The_synthetic_Tryptanthrin_analogue_suppresses_STATs_signalling_and_induces_caspase_dependent_apoptosis_via_ERK_up_regulation_in_human_leukemia_HL_60_cells"><img alt="Research paper thumbnail of 585: The synthetic Tryptanthrin analogue suppresses STATs signalling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/14865030/585_The_synthetic_Tryptanthrin_analogue_suppresses_STATs_signalling_and_induces_caspase_dependent_apoptosis_via_ERK_up_regulation_in_human_leukemia_HL_60_cells">585: The synthetic Tryptanthrin analogue suppresses STATs signalling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells</a></div><div class="wp-workCard_item"><span>European Journal of Cancer</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865030"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865030"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865030; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865030]").text(description); $(".js-view-count[data-work-id=14865030]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865030; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865030']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=14865030]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865030,"title":"585: The synthetic Tryptanthrin analogue suppresses STATs signalling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells","internal_url":"https://www.academia.edu/14865030/585_The_synthetic_Tryptanthrin_analogue_suppresses_STATs_signalling_and_induces_caspase_dependent_apoptosis_via_ERK_up_regulation_in_human_leukemia_HL_60_cells","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865029"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865029/Autophagy_triggered_by_magnolol_derivative_negatively_regulates_angiogenesis"><img alt="Research paper thumbnail of Autophagy triggered by magnolol derivative negatively regulates angiogenesis" class="work-thumbnail" src="https://attachments.academia-assets.com/43830857/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865029/Autophagy_triggered_by_magnolol_derivative_negatively_regulates_angiogenesis">Autophagy triggered by magnolol derivative negatively regulates angiogenesis</a></div><div class="wp-workCard_item"><span>Cell Death and Disease</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Angiogenesis has a key role in the tumor progression and metastasis; targeting endothelial cell p...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Angiogenesis has a key role in the tumor progression and metastasis; targeting endothelial cell proliferation has emerged as a promising therapeutic strategy for the prevention of cancer. Previous studies have revealed a complex association between the process of angiogenesis and autophagy and its outcome on tumorigenesis. Autophagy, also known as type-II cell death, has been identified as an alternative way of cell killing in apoptotic-resistant cancer cells. However, its involvement in chemoresistance and tumor promotion is also well known. In this study, we used a derivate of natural product magnolol (Ery5), a potent autophagy inducer, to study the association between the autophagy and angiogenesis in both in vitro and in vivo model system. We found that the robust autophagy triggered by Ery5, inhibited angiogenesis and caused cell death independent of the apoptosis in human umbilical cord vein endothelial cells and PC-3 cells. Ery5 induced autophagy effectively inhibited cell proliferation, migration, invasion and tube formation. We further demonstrated that Ery5-mediated autophagy and subsequent inhibition of angiogenesis was reversed when autophagy was inhibited through 3-methyl adenine and knocking down of key autophagy proteins ATG7 and microtubule-associated protein light chain 3. While evaluating the negative regulation of autophagy on angiogenesis, it was interesting to find that angiogenic environment produced by the treatment of VEGF and CoCl2 remarkably downregulated the autophagy and autophagic cell death induced by Ery5. These studies, while disclosing the vital role of autophagy in the regulation of angiogenesis, also suggest that the potent modulators of autophagy can lead to the development of effective therapeutics in apoptosis-resistant cancer.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="955aeb6d59d24dbcc443eb0caa296fc1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830857,"asset_id":14865029,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830857/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865029"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865029"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865029; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=14865029]").text(description); $(".js-view-count[data-work-id=14865029]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 14865029; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='14865029']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "955aeb6d59d24dbcc443eb0caa296fc1" } } $('.js-work-strip[data-work-id=14865029]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":14865029,"title":"Autophagy triggered by magnolol derivative negatively regulates angiogenesis","internal_url":"https://www.academia.edu/14865029/Autophagy_triggered_by_magnolol_derivative_negatively_regulates_angiogenesis","owner_id":33838613,"coauthors_can_edit":true,"owner":{"id":33838613,"first_name":"Shashi","middle_initials":null,"last_name":"Bhushan","page_name":"ShashiBhushan44","domain_name":"independent","created_at":"2015-08-11T22:51:50.477-07:00","display_name":"Shashi Bhushan","url":"https://independent.academia.edu/ShashiBhushan44"},"attachments":[{"id":43830857,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/43830857/thumbnails/1.jpg","file_name":"Autophagy_triggered_by_magnolol_derivati20160317-27665-vawphx.pdf","download_url":"https://www.academia.edu/attachments/43830857/download_file","bulk_download_file_name":"Autophagy_triggered_by_magnolol_derivati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/43830857/Autophagy_triggered_by_magnolol_derivati20160317-27665-vawphx-libre.pdf?1458245010=\u0026response-content-disposition=attachment%3B+filename%3DAutophagy_triggered_by_magnolol_derivati.pdf\u0026Expires=1740013949\u0026Signature=JftWos9Z7i7Ag-T5D0Ihm54t9OkBH~T2rPg8tZlDcFOPcncTv~Oquf84YBI6TY-JS5JOiCMFAQnKHWojrGIXn6ClFYxgoDI8kNQCvp6NXvL1eScJ5-1DRP~P1eShj76XWbV0JOIVov7t~7bitHNdeMNpdS-psIl2LmeLoJXChLK0uGnmH1EqQLgzXmfdgPtdAbFUOyQ9gsVKqfQ33iimvLxTkvdbXkr4owCx2KKmuRWlV4ziltnt~lXoTd5ijSsH8SOpFyn8dIIGMTjQZpUERNxvwdHAla8Sh0oBKXzdIllx54D7l4IWSRZWLLnLeKvSuKsFTuVaWRk~l8z6-VfAkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="14865028"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/14865028/Characterization_of_a_novel_zinc_metalloprotease_involved_in_degrading_targeting_peptides_in_mitochondria_and_chloroplasts"><img alt="Research paper thumbnail of Characterization of a novel zinc metalloprotease involved in degrading targeting peptides in mitochondria and chloroplasts" class="work-thumbnail" src="https://attachments.academia-assets.com/43830846/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/14865028/Characterization_of_a_novel_zinc_metalloprotease_involved_in_degrading_targeting_peptides_in_mitochondria_and_chloroplasts">Characterization of a novel zinc metalloprotease involved in degrading targeting peptides in mitochondria and chloroplasts</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Both authors contributed equally to this work.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f522cfe688c973effe06ebefa13353ba" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":43830846,"asset_id":14865028,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/43830846/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="14865028"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="14865028"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 14865028; 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