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</div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Sex hormone-binding globulin</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 15 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-15" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">15 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/SHBG" title="SHBG – Bosnian" lang="bs" hreflang="bs" data-title="SHBG" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Globulina_d%27uni%C3%B3_a_hormones_sexuals" title="Globulina d'unió a hormones sexuals – Catalan" lang="ca" hreflang="ca" data-title="Globulina d'unió a hormones sexuals" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Sexualhormon-bindendes_Globulin" title="Sexualhormon-bindendes Globulin – German" lang="de" hreflang="de" data-title="Sexualhormon-bindendes Globulin" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Globulina_fijadora_de_hormonas_sexuales" title="Globulina fijadora de hormonas sexuales – Spanish" lang="es" hreflang="es" data-title="Globulina fijadora de hormonas sexuales" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Sex_hormone-binding_globulin" title="Sex hormone-binding globulin – French" lang="fr" hreflang="fr" data-title="Sex hormone-binding globulin" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Globuline_leganti_gli_ormoni_sessuali" title="Globuline leganti gli ormoni sessuali – Italian" lang="it" hreflang="it" data-title="Globuline leganti gli ormoni sessuali" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A1%D0%B5%D0%BA%D1%81_%D1%85%D0%BE%D1%80%D0%BC%D0%BE%D0%BD-%D0%B2%D1%80%D0%B7%D1%83%D0%B2%D0%B0%D1%87%D0%BA%D0%B8_%D0%B3%D0%BB%D0%BE%D0%B1%D1%83%D0%BB%D0%B8%D0%BD" title="Секс хормон-врзувачки глобулин – Macedonian" lang="mk" hreflang="mk" data-title="Секс хормон-врзувачки глобулин" data-language-autonym="Македонски" data-language-local-name="Macedonian" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E6%80%A7%E3%83%9B%E3%83%AB%E3%83%A2%E3%83%B3%E7%B5%90%E5%90%88%E3%82%B0%E3%83%AD%E3%83%96%E3%83%AA%E3%83%B3" title="性ホルモン結合グロブリン – Japanese" lang="ja" hreflang="ja" data-title="性ホルモン結合グロブリン" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/SHBG" title="SHBG – Polish" lang="pl" hreflang="pl" data-title="SHBG" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Globulina_ligadora_de_horm%C3%B4nios_sexuais" title="Globulina ligadora de hormônios sexuais – Portuguese" lang="pt" hreflang="pt" data-title="Globulina ligadora de hormônios sexuais" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%BB%D0%BE%D0%B1%D1%83%D0%BB%D0%B8%D0%BD,_%D1%81%D0%B2%D1%8F%D0%B7%D1%8B%D0%B2%D0%B0%D1%8E%D1%89%D0%B8%D0%B9_%D0%BF%D0%BE%D0%BB%D0%BE%D0%B2%D1%8B%D0%B5_%D0%B3%D0%BE%D1%80%D0%BC%D0%BE%D0%BD%D1%8B" title="Глобулин, связывающий половые гормоны – Russian" lang="ru" hreflang="ru" data-title="Глобулин, связывающий половые гормоны" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/K%C3%B6nshormonbindande_globulin" title="Könshormonbindande globulin – Swedish" lang="sv" hreflang="sv" data-title="Könshormonbindande globulin" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/SHBG" title="SHBG – Tatar" lang="tt" hreflang="tt" data-title="SHBG" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/SHBG" title="SHBG – Ukrainian" lang="uk" hreflang="uk" data-title="SHBG" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E6%80%A7%E6%BF%80%E7%B4%A0%E7%BB%93%E5%90%88%E7%90%83%E8%9B%8B%E7%99%BD" title="性激素结合球蛋白 – Chinese" lang="zh" hreflang="zh" data-title="性激素结合球蛋白" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q419613#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu 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<div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Human glycoprotein that binds to androgens and estrogens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">SHBG</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:1d2s_SHBG.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f1/1d2s_SHBG.png/250px-1d2s_SHBG.png" decoding="async" width="250" height="195" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f1/1d2s_SHBG.png/375px-1d2s_SHBG.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f1/1d2s_SHBG.png/500px-1d2s_SHBG.png 2x" data-file-width="1252" data-file-height="977" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P97497%20or%20P04278%20or%20B0FWH6">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P97497,P04278,B0FWH6">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1LHW">1LHW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1D2S">1D2S</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1F5F">1F5F</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1KDK">1KDK</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1KDM">1KDM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1LHN">1LHN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1LHO">1LHO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1LHU">1LHU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1LHV">1LHV</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/10839">SHBG</a></span>, ABP, SBP, TEBG, sex hormone binding globulin, Sex hormone-binding globulin</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/182205">182205</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:98295">98295</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=813">813</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SHBG">SHBG</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000129214">SHBG - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/450px-Ideogram_human_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/600px-Ideogram_human_chromosome_17.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_17_(human)" class="mw-redirect" title="Chromosome 17 (human)">Chromosome 17 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_17_ideogram.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/300px-Human_chromosome_17_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/450px-Human_chromosome_17_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/600px-Human_chromosome_17_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 21.533000355425px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SHBG"><img alt="Genomic location for SHBG" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 27.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SHBG"><img alt="Genomic location for SHBG" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">17p13.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">7,613,946 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">7,633,382 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/390px-Ideogram_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/520px-Ideogram_house_mouse_chromosome_11.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 11 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/300px-Ideogram_of_house_mouse_chromosome_11.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/450px-Ideogram_of_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/600px-Ideogram_of_house_mouse_chromosome_11.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 162.0634957714px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SHBG"><img alt="Genomic location for SHBG" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 168.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SHBG"><img alt="Genomic location for SHBG" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">11 B3|11 42.86 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">69,505,630 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">69,508,731 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000129214">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right lobe of liver</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">right testis</li><br /><li style="line-height: 137%;">left testis</li><br /><li style="line-height: 137%;">right adrenal cortex</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">jejunal mucosa</li><br /><li style="line-height: 137%;">left adrenal gland</li><br /><li style="line-height: 137%;">left adrenal cortex</li><br /><li style="line-height: 137%;">human kidney</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000005202">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">morula</li><br /><li style="line-height: 137%;">spermatocyte</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">Ileal epithelium</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">perirhinal cortex</li><br /><li style="line-height: 137%;">entorhinal cortex</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">choroid plexus of fourth ventricle</li><br /><li style="line-height: 137%;">CA3 field</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000129214">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_SHBG_215689_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PBB_GE_SHBG_215689_s_at_fs.png/250px-PBB_GE_SHBG_215689_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PBB_GE_SHBG_215689_s_at_fs.png/375px-PBB_GE_SHBG_215689_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9f/PBB_GE_SHBG_215689_s_at_fs.png/500px-PBB_GE_SHBG_215689_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/6462/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6462&rn=1">6462</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=20415&rn=1">20415</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000129214;db=core">ENSG00000129214</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000005202;db=core">ENSMUSG00000005202</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P04278">P04278</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P97497">P97497</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001040">NM_001040</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001146279">NM_001146279</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001146280">NM_001146280</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001146281">NM_001146281</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001289113">NM_001289113</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001289114">NM_001289114</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001289115">NM_001289115</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001289116">NM_001289116</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_011367">NM_011367</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001031">NP_001031</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001139751">NP_001139751</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001139752">NP_001139752</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001139753">NP_001139753</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276042">NP_001276042</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276043">NP_001276043</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276044">NP_001276044</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276045">NP_001276045</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_035497">NP_035497</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr17:7613946-7633382">Chr 17: 7.61 – 7.63 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr11:69505630-69508731">Chr 11: 69.51 – 69.51 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14865325" class="extiw" title="d:Q14865325">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14865326" class="extiw" title="d:Q14865326">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Androgen-binding protein, Sex hormone-binding globulin</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">SHBG</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">ABP</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=6462&rn=1">6462</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10839">10839</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/182205">182205</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NM_001040">NM_001040</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P04278">P04278</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_17_(human)" class="mw-redirect" title="Chromosome 17 (human)">Chr. 17</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=17p13">p13-p12</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/P04278">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/P04278">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Sex hormone-binding globulin</b> (<b>SHBG</b>) or <b>sex steroid-binding globulin</b> (<b>SSBG</b>) is a <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoprotein</a> that binds to <a href="/wiki/Androgen" title="Androgen">androgens</a> and <a href="/wiki/Estrogen" title="Estrogen">estrogens</a>. When produced by the <a href="/wiki/Sertoli_cells" class="mw-redirect" title="Sertoli cells">Sertoli cells</a> in the <a href="/wiki/Seminiferous_tubules" class="mw-redirect" title="Seminiferous tubules">seminiferous tubules</a> of the <a href="/wiki/Testis" class="mw-redirect" title="Testis">testis</a>, it is called <b>androgen-binding protein</b> (<b>ABP</b>).<sup id="cite_ref-Bardin_1981_5-0" class="reference"><a href="#cite_note-Bardin_1981-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hansson_1976_6-0" class="reference"><a href="#cite_note-Hansson_1976-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Other <a href="/wiki/Steroid_hormone" title="Steroid hormone">steroid hormones</a> such as <a href="/wiki/Progesterone" title="Progesterone">progesterone</a>, <a href="/wiki/Cortisol" title="Cortisol">cortisol</a>, and other <a href="/wiki/Corticosteroids" class="mw-redirect" title="Corticosteroids">corticosteroids</a> are bound by <a href="/wiki/Transcortin" title="Transcortin">transcortin</a>. SHBG is found in all vertebrates apart from birds.<sup id="cite_ref-Hammond2011_7-0" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Testosterone and estradiol circulate in the bloodstream, loosely bound mostly to <a href="/wiki/Serum_albumin" title="Serum albumin">serum albumin</a> (~54%), and to a lesser extent bound tightly to SHBG (~44%). Only a very small fraction of about 1 to 2% is unbound, or "free," and thus biologically active and able to enter a <a href="/wiki/Cell_(biology)" title="Cell (biology)">cell</a> and activate its <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptor</a>. SHBG inhibits the function of these hormones. Thus, the local bioavailability of sex hormones is influenced by the level of SHBG. Because SHBG binds to <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> (T) and <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a> (DHT), these hormones are made less lipophilic and become concentrated within the luminal fluid of the seminiferous tubules. The higher levels of these hormones enable <a href="/wiki/Spermatogenesis" title="Spermatogenesis">spermatogenesis</a> in the <a href="/wiki/Seminiferous_tubules" class="mw-redirect" title="Seminiferous tubules">seminiferous tubules</a> and sperm maturation in the <a href="/wiki/Epididymis" title="Epididymis">epididymis</a>. SHBG’s production is regulated under the influence of <a href="/wiki/Follicle-stimulating_hormone" title="Follicle-stimulating hormone">FSH</a><sup id="cite_ref-Hansson_1976_6-1" class="reference"><a href="#cite_note-Hansson_1976-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> on Sertoli cells, enhanced by <a href="/wiki/Insulin" title="Insulin">insulin</a>, <a href="/wiki/Retinol" title="Retinol">retinol</a>, and <a href="/wiki/Testosterone" title="Testosterone">testosterone</a>. </p><p>The relative binding affinity of various sex steroids for SHBG is <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a> (DHT) > <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> > <a href="/wiki/Androstenediol" title="Androstenediol">androstenediol</a> > <a href="/wiki/Estradiol" title="Estradiol">estradiol</a> > <a href="/wiki/Estrone" title="Estrone">estrone</a>.<sup id="cite_ref-pmid15180949_8-0" class="reference"><a href="#cite_note-pmid15180949-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> DHT binds to SHBG with about 5 times the affinity of testosterone and about 20 times the affinity of estradiol.<sup id="cite_ref-Hammond2017_9-0" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">Dehydroepiandrosterone</a> (DHEA) is weakly bound to SHBG, but <a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">dehydroepiandrosterone sulfate</a> is not bound to SHBG.<sup id="cite_ref-pmid15180949_8-1" class="reference"><a href="#cite_note-pmid15180949-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Androstenedione" title="Androstenedione">Androstenedione</a> is not bound to SHBG either, and is instead bound solely to albumin.<sup id="cite_ref-Principles_and_Practice_of_Endocrinology_and_Metabolism_10-0" class="reference"><a href="#cite_note-Principles_and_Practice_of_Endocrinology_and_Metabolism-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Estrone_sulfate" title="Estrone sulfate">Estrone sulfate</a> and <a href="/wiki/Estriol" title="Estriol">estriol</a> are also poorly bound by SHBG.<sup id="cite_ref-Buchsbaum2012_11-0" class="reference"><a href="#cite_note-Buchsbaum2012-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Less than 1% of <a href="/wiki/Progesterone" title="Progesterone">progesterone</a> is bound to SHBG.<sup id="cite_ref-FritzSperoff2012_12-0" class="reference"><a href="#cite_note-FritzSperoff2012-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p><p>SHBG levels are usually about twice as high in women as in men.<sup id="cite_ref-Hammond2017_9-1" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> In women, SHBG serves to limit exposure to both <a href="/wiki/Androgen" title="Androgen">androgens</a> and <a href="/wiki/Estrogen" title="Estrogen">estrogens</a>.<sup id="cite_ref-Hammond2017_9-2" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Low SHBG levels in women have been associated with <a href="/wiki/Hyperandrogenism" title="Hyperandrogenism">hyperandrogenism</a> and <a href="/wiki/Endometrial_cancer" title="Endometrial cancer">endometrial cancer</a> due to heightened exposure to androgens and estrogens, respectively.<sup id="cite_ref-Hammond2017_9-3" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> During <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a>, due to activation of SHBG production in the <a href="/wiki/Liver" title="Liver">liver</a> by high estrogen levels, SHBG levels increase by five-fold to ten-fold.<sup id="cite_ref-Hammond2017_9-4" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The high SHBG levels during pregnancy may serve to protect the mother from exposure to <a href="/wiki/Fetus" title="Fetus">fetal</a> androgens that escape <a href="/wiki/Metabolism" title="Metabolism">metabolism</a> by the <a href="/wiki/Placenta" title="Placenta">placenta</a>.<sup id="cite_ref-Hammond2017_9-5" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> A <a href="/wiki/Case_report" title="Case report">case report</a> of severe hyperandrogenism in a pregnant woman due to a rare instance of genetic SHBG deficiency illustrates this.<sup id="cite_ref-Hammond2017_9-6" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11927624_13-0" class="reference"><a href="#cite_note-pmid11927624-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Biochemistry">Biochemistry</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=2" title="Edit section: Biochemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Biosynthesis">Biosynthesis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=3" title="Edit section: Biosynthesis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SHBG is produced mostly by the <a href="/wiki/Liver" title="Liver">liver</a> and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta.<sup id="cite_ref-Hammond96_14-0" class="reference"><a href="#cite_note-Hammond96-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Testes-produced SHBG is called androgen-binding protein. </p> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=4" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/Gene" title="Gene">gene</a> for SHBG is called <i>Shbg</i> located on <a href="/wiki/Chromosome_17" title="Chromosome 17">chromosome 17</a><sup id="cite_ref-Hammond96_14-1" class="reference"><a href="#cite_note-Hammond96-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> on the short arm between the bands 17p12→p13.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Overlapping on the complementary DNA strand is the gene for <a href="/wiki/Spermidine" title="Spermidine">spermidine</a>/<a href="/wiki/Spermine" title="Spermine">spermine</a> N1-acetyltransferase family member 2 (<a href="/wiki/SAT2" title="SAT2">SAT2</a>). Nearby are the genes for <a href="/wiki/P53" title="P53">p53</a> and <a href="/w/index.php?title=ATP1B2&action=edit&redlink=1" class="new" title="ATP1B2 (page does not exist)">ATP1B2</a>, and <a href="/wiki/Fragile_X_mental_retardation,_autosomal_homolog_2" class="mw-redirect" title="Fragile X mental retardation, autosomal homolog 2">fragile X mental retardation, autosomal homolog 2</a> (FXR2) on the complementary strand.<sup id="cite_ref-Joseph_16-0" class="reference"><a href="#cite_note-Joseph-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> There are eight exons, of which exon 1 has three variations called 1L, 1T and 1N which are triggered by three promoters: P<sub>L</sub>, P<sub>T</sub> and P<sub>N</sub> respectively. SHBG comes with the 1L, 2, 3, 4, 5, 6, 7, and 8 exons connected together. A variation includes SHBG-T which is missing exon 7 but with exon 1T promoted by promoter P<sub>T</sub> on the opposite strand, which shared with that for SAT2.<sup id="cite_ref-Nakhla2009_17-0" class="reference"><a href="#cite_note-Nakhla2009-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Polymorphisms">Polymorphisms</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=5" title="Edit section: Polymorphisms"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There are variations in the genetic material for this protein that have different effects. In humans common polymorphisms include the following: </p><p>Rs6259, also called Asp327Asn location 7633209 on Chromosome 17, results in there being an extra N-glycosilation site, and so an extra sugar can be attached. This results in a longer circulation half-life for the protein, and raised levels. A health effect is a lowered risk of <a href="/wiki/Endometrial_cancer" title="Endometrial cancer">endometrial cancer</a>, and another is an increased risk of <a href="/wiki/Systemic_lupus_erythematosus" class="mw-redirect" title="Systemic lupus erythematosus">systemic lupus erythematosus</a>.<sup id="cite_ref-Piotrowski2009_18-0" class="reference"><a href="#cite_note-Piotrowski2009-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p><p>Rs6258 also called Ser156Pro is at position 7631360 on the Chromosome 17. </p><p>Rs727428 position 7634474 is in several percent of humans.<sup id="cite_ref-Svartberg2014_19-0" class="reference"><a href="#cite_note-Svartberg2014-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>(TAAAA)(n) is five base pairs that repeats a variable number of times on the opposite DNA strand.<sup id="cite_ref-Thompson2008_20-0" class="reference"><a href="#cite_note-Thompson2008-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Promoter_activation">Promoter activation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=6" title="Edit section: Promoter activation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The mechanism of activating the promoter for SHBG in the liver involves <a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">hepatocyte nuclear factor 4 alpha</a> (<a href="/wiki/HNF4A" class="mw-redirect" title="HNF4A">HNF4A</a>) binding to a DR1 like cis element which then stimulate production. Competing with HNF4A at a third site on the promoter is PPARG-2 which reduces copying the gene to RNA. If HNF4A level is low then <a href="/wiki/COUP-TF" class="mw-redirect" title="COUP-TF">COUP-TF</a> binds to the first site and turns off production of SHBG.<sup id="cite_ref-Hammond2011_7-1" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Protein">Protein</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=7" title="Edit section: Protein"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Sex hormone-binding globulin is homodimeric, meaning it has two identical peptide chains making up its structure. The amino acid sequence is the same as for <a href="/wiki/Androgen-binding_protein" class="mw-redirect" title="Androgen-binding protein">androgen-binding protein</a> but that has different <a href="/wiki/Oligosaccharides" class="mw-redirect" title="Oligosaccharides">oligosaccharides</a> attached and is produced in testes.<sup id="cite_ref-Hammond96_14-2" class="reference"><a href="#cite_note-Hammond96-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p>SHBG has two laminin G-like domains which form pockets that bind hydrophobic molecules. The steroids are bound by the LG domain at the amino end of the protein.<sup id="cite_ref-Hammond2011_7-2" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Inside the pocket of the domain is a serine residue that attracts the two different types of steroids at different points, thus changing their orientation. Androgens bind at the C3 functional groups on the A ring, and estrogens bind via a hydroxyl attached to C17 on the D ring. The two different orientations change a loop over the entrance to the pocket and the position of trp84 (in humans). Thus the whole protein signals what hormone it carries on its own surface.<sup id="cite_ref-Hammond2011_7-3" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The steroid binding LG domain is coded by exons 2 to 5.<sup id="cite_ref-Hammond2011_7-4" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> A linker region joins the two LG domains together.<sup id="cite_ref-Hammond2011_7-5" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>When first produced the SHBG precursor has a leading signal peptide attached with 29 amino acids. The remaining peptide has 373 amino acids.<sup id="cite_ref-Hammond1987_21-0" class="reference"><a href="#cite_note-Hammond1987-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> There are two sulfur bridges. </p><p>The sugars are attached at two different <a href="/wiki/N-glycosylation" class="mw-redirect" title="N-glycosylation">N-glycosylation</a> points on asparagine (351 and 367) and one <a href="/wiki/O-glycosylation" class="mw-redirect" title="O-glycosylation">O-glycosylation</a> (7) point on threonine.<sup id="cite_ref-Hammond1987_21-1" class="reference"><a href="#cite_note-Hammond1987-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Metals">Metals</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=8" title="Edit section: Metals"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>A calcium ion is needed to link the two elements of the dimer together. Also a zinc ion is used to orient an otherwise disorganised part of the peptide chain.<sup id="cite_ref-Hammond2011_7-6" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Regulation">Regulation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=9" title="Edit section: Regulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SHBG has both enhancing and inhibiting hormonal influences thus can be viewed as a <a href="/wiki/Hepatokine" title="Hepatokine">hepatokine</a>. It decreases with high levels of <a href="/wiki/Insulin" title="Insulin">insulin</a>, <a href="/wiki/Growth_hormone" title="Growth hormone">growth hormone</a>, <a href="/wiki/Insulin-like_growth_factor_1" title="Insulin-like growth factor 1">insulin-like growth factor 1</a> (IGF-1), <a href="/wiki/Androgen" title="Androgen">androgens</a>, <a href="/wiki/Prolactin" title="Prolactin">prolactin</a> and <a href="/wiki/Transcortin" title="Transcortin">transcortin</a>. High <a href="/wiki/Estrogen" title="Estrogen">estrogen</a> and <a href="/wiki/Thyroxine" class="mw-redirect" title="Thyroxine">thyroxine</a> levels cause it to increase. </p><p>In an effort to explain obesity-related reductions in SHBG, recent evidence suggests sugar or monosaccharide-induced <a href="/wiki/Liver" title="Liver">hepatic</a> lipogenesis, hepatic lipids in general, and cytokines like TNF-alpha and Interleukin reduce SHBG, whereas insulin does not. As an example anti-psoriatic drugs that inhibit <a href="/wiki/TNF-alpha" class="mw-redirect" title="TNF-alpha">TNF-alpha</a> cause an increase in SHBG. The common downstream mechanism for all of these, including the effect of thyroid hormones<sup id="cite_ref-pmid19336534_22-0" class="reference"><a href="#cite_note-pmid19336534-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> was downregulation of HNF4, hepatocyte nuclear factor 4.<sup id="cite_ref-Sugar_23-0" class="reference"><a href="#cite_note-Sugar-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid22902540_24-0" class="reference"><a href="#cite_note-pmid22902540-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid22210320_25-0" class="reference"><a href="#cite_note-pmid22210320-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid23066943_26-0" class="reference"><a href="#cite_note-pmid23066943-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Blood_values">Blood values</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=10" title="Edit section: Blood values"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Reference_ranges_for_blood_tests" title="Reference ranges for blood tests">Reference ranges for blood tests</a> for SHBG have been developed:<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p> <table class="wikitable"> <tbody><tr> <th>Population</th> <th>Range </th></tr> <tr> <td>Adult female, premenopausal</td> <td>40–120 nmol/L </td></tr> <tr> <td>Adult female, postmenopausal</td> <td>28–112 nmol/L </td></tr> <tr> <td>Adult male</td> <td>20–60 nmol/L </td></tr> <tr> <td>Infant (1–23 months)</td> <td>60–252 nmol/L </td></tr> <tr> <td>Prepubertal (2 years–8 years)</td> <td>72–220 nmol/L </td></tr> <tr> <td>Pubertal female</td> <td>36–125 nmol/L </td></tr> <tr> <td>Pubertal male</td> <td>16–100 nmol/L </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=11" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="High_or_low_levels">High or low levels</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=12" title="Edit section: High or low levels"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Estrogen,_progesterone,_testosterone,_and_SHBG_levels_during_pregnancy_in_women.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/83/Estrogen%2C_progesterone%2C_testosterone%2C_and_SHBG_levels_during_pregnancy_in_women.png/400px-Estrogen%2C_progesterone%2C_testosterone%2C_and_SHBG_levels_during_pregnancy_in_women.png" decoding="async" width="400" height="234" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/83/Estrogen%2C_progesterone%2C_testosterone%2C_and_SHBG_levels_during_pregnancy_in_women.png/600px-Estrogen%2C_progesterone%2C_testosterone%2C_and_SHBG_levels_during_pregnancy_in_women.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/83/Estrogen%2C_progesterone%2C_testosterone%2C_and_SHBG_levels_during_pregnancy_in_women.png/800px-Estrogen%2C_progesterone%2C_testosterone%2C_and_SHBG_levels_during_pregnancy_in_women.png 2x" data-file-width="2048" data-file-height="1196" /></a><figcaption>Levels of sex hormones and SHBG during pregnancy in women.<sup id="cite_ref-pmid8137527_29-0" class="reference"><a href="#cite_note-pmid8137527-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></figcaption></figure> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Sex_hormone-binding_globulin_(SHBG)_and_estradiol_levels_during_pregnancy_in_women.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Sex_hormone-binding_globulin_%28SHBG%29_and_estradiol_levels_during_pregnancy_in_women.png/400px-Sex_hormone-binding_globulin_%28SHBG%29_and_estradiol_levels_during_pregnancy_in_women.png" decoding="async" width="400" height="250" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Sex_hormone-binding_globulin_%28SHBG%29_and_estradiol_levels_during_pregnancy_in_women.png/600px-Sex_hormone-binding_globulin_%28SHBG%29_and_estradiol_levels_during_pregnancy_in_women.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/13/Sex_hormone-binding_globulin_%28SHBG%29_and_estradiol_levels_during_pregnancy_in_women.png/800px-Sex_hormone-binding_globulin_%28SHBG%29_and_estradiol_levels_during_pregnancy_in_women.png 2x" data-file-width="2582" data-file-height="1614" /></a><figcaption>Levels of SHBG and estradiol during pregnancy in women.<sup id="cite_ref-pmid1827758_30-0" class="reference"><a href="#cite_note-pmid1827758-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> For SHBG the lines are the mean and 95th percentile levels while the points are individual measurements.<sup id="cite_ref-pmid1827758_30-1" class="reference"><a href="#cite_note-pmid1827758-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> For estradiol the line is the mean level.<sup id="cite_ref-pmid1827758_30-2" class="reference"><a href="#cite_note-pmid1827758-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> The dashed parts of the lines are extrapolated.<sup id="cite_ref-pmid1827758_30-3" class="reference"><a href="#cite_note-pmid1827758-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup></figcaption></figure> <figure class="mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/File:Sex_hormone-binding_globulin_binding_capacity_during_pregnancy_in_women.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Sex_hormone-binding_globulin_binding_capacity_during_pregnancy_in_women.png/400px-Sex_hormone-binding_globulin_binding_capacity_during_pregnancy_in_women.png" decoding="async" width="400" height="254" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Sex_hormone-binding_globulin_binding_capacity_during_pregnancy_in_women.png/600px-Sex_hormone-binding_globulin_binding_capacity_during_pregnancy_in_women.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Sex_hormone-binding_globulin_binding_capacity_during_pregnancy_in_women.png/800px-Sex_hormone-binding_globulin_binding_capacity_during_pregnancy_in_women.png 2x" data-file-width="2483" data-file-height="1575" /></a><figcaption>SHBG binding capacity during pregnancy in women.<sup id="cite_ref-pmid561671_31-0" class="reference"><a href="#cite_note-pmid561671-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>SHBG levels are <i>decreased</i> by androgens, administration of <a href="/wiki/Anabolic_steroid" title="Anabolic steroid">anabolic steroids</a>,<sup id="cite_ref-pmid3160892_32-0" class="reference"><a href="#cite_note-pmid3160892-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Polycystic_ovary_syndrome" title="Polycystic ovary syndrome">polycystic ovary syndrome</a>, <a href="/wiki/Hypothyroidism" title="Hypothyroidism">hypothyroidism</a>, <a href="/wiki/Obesity" title="Obesity">obesity</a>, <a href="/wiki/Cushing%27s_syndrome" title="Cushing's syndrome">Cushing's syndrome</a>, and <a href="/wiki/Acromegaly" title="Acromegaly">acromegaly</a>. Low SHBG levels increase the probability of <a href="/wiki/Type_2_Diabetes" class="mw-redirect" title="Type 2 Diabetes">Type 2 Diabetes</a>.<sup id="cite_ref-Ding2009_33-0" class="reference"><a href="#cite_note-Ding2009-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> SHBG levels <i>increase</i> with estrogenic states (<a href="/wiki/Oral_contraceptive" class="mw-redirect" title="Oral contraceptive">oral contraceptives</a>), <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a>, <a href="/wiki/Hyperthyroidism" title="Hyperthyroidism">hyperthyroidism</a>, <a href="/wiki/Cirrhosis" title="Cirrhosis">cirrhosis</a>, <a href="/wiki/Anorexia_nervosa" title="Anorexia nervosa">anorexia nervosa</a>, and certain <a href="/wiki/Drug" title="Drug">drugs</a>. Long-term <a href="/wiki/Calorie_restriction" title="Calorie restriction">calorie restriction</a> increases SHBG in rodents and men, while lowering free and total testosterone and estradiol and having no effect on <a href="/wiki/DHEA-S" class="mw-redirect" title="DHEA-S">DHEA-S</a>, which lacks affinity for SHBG.<sup id="cite_ref-pmid20096034_34-0" class="reference"><a href="#cite_note-pmid20096034-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Polycystic_Ovarian_Syndrome" class="mw-redirect" title="Polycystic Ovarian Syndrome">Polycystic Ovarian Syndrome</a> is associated with insulin resistance and excess insulin lowers SHBG, which increases free testosterone levels.<sup id="cite_ref-pmid4040924_35-0" class="reference"><a href="#cite_note-pmid4040924-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> </p><p>In the womb the human fetus has a low level of SHBG allowing increased activity of sex hormones. After birth, the SHBG level rises and remains at a high level throughout childhood. At puberty the SHBG level halves in girls and goes down to a quarter in boys.<sup id="cite_ref-Hammond2011_7-7" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> The change at puberty is triggered by <a href="/wiki/Growth_hormone" title="Growth hormone">growth hormone</a>, and its pulsatility differs in boys and girls.<sup class="noprint Inline-Template" style="margin-left:0.1em; white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Please_clarify" title="Wikipedia:Please clarify"><span title="(September 2019)">clarification needed</span></a></i>]</sup> In pregnant women in the third trimester of pregnancy the SHBG level escalates to five to ten times the usual level for a woman.<sup id="cite_ref-Hammond2011_7-8" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hammond2017_9-7" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> A hypothesis is that this protects against the effect of hormone produced by the fetus.<sup id="cite_ref-Hammond2011_7-9" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Obese girls are more likely to have an early <a href="/wiki/Menarche" title="Menarche">menarche</a> due to lower levels of SHBG.<sup id="cite_ref-Hammond2011_7-10" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Anorexia or a lean physique in women leads to higher SHBG levels, which in turn can lead to <a href="/wiki/Amenorrhea" title="Amenorrhea">amenorrhea</a>.<sup id="cite_ref-Hammond2011_7-11" class="reference"><a href="#cite_note-Hammond2011-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Type_2_diabetes">Type 2 diabetes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=13" title="Edit section: Type 2 diabetes"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Reduced levels of SHBG and also certain <a href="/wiki/Gene_polymorphism" title="Gene polymorphism">polymorphisms</a> of the SHBG gene are implicated in the development of <a href="/wiki/Insulin_resistance" title="Insulin resistance">insulin resistance</a> and <a href="/wiki/Type_2_diabetes" title="Type 2 diabetes">type 2 diabetes</a>.<sup id="cite_ref-Le12_36-0" class="reference"><a href="#cite_note-Le12-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> Such effects apparently involve direct action at the cellular level where it became apparent that cell membranes of certain tissues contain specific high-affinity SHBG receptors.<sup id="cite_ref-Rosner10_37-0" class="reference"><a href="#cite_note-Rosner10-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Coagulation">Coagulation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=14" title="Edit section: Coagulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SHBG is a useful correlate and indirect marker of estrogen-induced procoagulation and by extension <a href="/wiki/Thrombosis" title="Thrombosis">thrombosis</a>, for instance with <a href="/wiki/Birth_control_pill" class="mw-redirect" title="Birth control pill">birth control pills</a>.<sup id="cite_ref-pmid20163835_38-0" class="reference"><a href="#cite_note-pmid20163835-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12047300_39-0" class="reference"><a href="#cite_note-pmid12047300-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid34956081_40-0" class="reference"><a href="#cite_note-pmid34956081-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Medications">Medications</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=15" title="Edit section: Medications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Oral_contraceptive" class="mw-redirect" title="Oral contraceptive">Oral contraceptives</a> containing <a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">ethinylestradiol</a> can increase SHBG levels by 2- to 4-fold and decrease free testosterone concentrations by 40 to 80% in women.<sup id="cite_ref-HumansOrganization2007_41-0" class="reference"><a href="#cite_note-HumansOrganization2007-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> They can be used to treat <a href="/wiki/Symptom" class="mw-redirect" title="Symptom">symptoms</a> of <a href="/wiki/Hyperandrogenism" title="Hyperandrogenism">hyperandrogenism</a> like <a href="/wiki/Acne" title="Acne">acne</a> and <a href="/wiki/Hirsutism" title="Hirsutism">hirsutism</a>.<sup id="cite_ref-HumansOrganization2007_41-1" class="reference"><a href="#cite_note-HumansOrganization2007-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hammond2017_9-8" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Some oral contraceptives, namely those containing high doses of ethinylestradiol (which have been discontinued and are no longer marketed), can increase SHBG levels by as much as 5- to 10-fold.<sup id="cite_ref-Hammond2017_9-9" class="reference"><a href="#cite_note-Hammond2017-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Some medications, such as certain <a href="/wiki/Anabolic_steroid" title="Anabolic steroid">anabolic steroids</a> like <a href="/wiki/Mesterolone" title="Mesterolone">mesterolone</a> and <a href="/wiki/Danazol" title="Danazol">danazol</a> and certain <a href="/wiki/Progestin" class="mw-redirect" title="Progestin">progestins</a> like <a href="/wiki/Levonorgestrel" title="Levonorgestrel">levonorgestrel</a> and <a href="/wiki/Norethisterone" title="Norethisterone">norethisterone</a>, have high affinity for SHBG and can bind to it and displace <a href="/wiki/Endogenous" class="mw-redirect" title="Endogenous">endogenous</a> <a href="/wiki/Steroid" title="Steroid">steroids</a> from it, thereby increasing free concentrations of these endogenous steroids.<sup id="cite_ref-pmid7195405_42-0" class="reference"><a href="#cite_note-pmid7195405-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid6539197_43-0" class="reference"><a href="#cite_note-pmid6539197-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16112947_44-0" class="reference"><a href="#cite_note-pmid16112947-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> It has been estimated that therapeutic levels of danazol, <a href="/wiki/Methyltestosterone" title="Methyltestosterone">methyltestosterone</a>, <a href="/wiki/Fluoxymesterone" title="Fluoxymesterone">fluoxymesterone</a>, levonorgestrel, and norethisterone would respectively occupy or displace from testosterone 83–97%, 48–69%, 42–64%, 16–47%, and 4–39% of SHBG binding sites, while others with low affinity for SHBG such as <a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">ethinylestradiol</a>, <a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">cyproterone acetate</a>, and <a href="/wiki/Medroxyprogesterone_acetate" title="Medroxyprogesterone acetate">medroxyprogesterone acetate</a> would occupy or displace from testosterone 1% or fewer SHBG binding sites.<sup id="cite_ref-pmid7195405_42-1" class="reference"><a href="#cite_note-pmid7195405-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7200170_45-0" class="reference"><a href="#cite_note-pmid7200170-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Selective_androgen_receptor_modulators" class="mw-redirect" title="Selective androgen receptor modulators">Selective androgen receptor modulators</a> (SARMs) also reduce SHBG.<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> </p> <table class="wikitable center sortable mw-collapsible mw-collapsed" style="width:675px; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption class="nowrap">Affinities of 70 medications for SHBG and CBG<sup id="cite_ref-pmid7195405_42-2" class="reference"><a href="#cite_note-pmid7195405-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Compound</th> <th>Structure</th> <th data-sort-type="number">SHBG<br /><abbr title="Relative binding affinity">RBA</abbr> (%)</th> <th data-sort-type="number">SHBG<br />K (10<sup>6</sup> M<sup>−1</sup>)</th> <th data-sort-type="number">CBG<br /><abbr title="Relative binding affinity">RBA</abbr> (%)</th> <th data-sort-type="number">CBG<br />K (10<sup>6</sup> M<sup>−1</sup>) </th></tr> <tr> <td><a href="/wiki/Aminoglutethimide" title="Aminoglutethimide">Aminoglutethimide</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Androstanolone" title="Androstanolone">Androstanolone</a></td> <td>Steroidal</td> <td>220</td> <td>5500</td> <td>1.3</td> <td>0.83 </td></tr> <tr> <td><a href="/wiki/Betamethasone" title="Betamethasone">Betamethasone</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Cholecalciferol" title="Cholecalciferol">Cholecalciferol</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Cimetidine" title="Cimetidine">Cimetidine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Clomifene" title="Clomifene">Clomifene</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Hydrocortisone" title="Hydrocortisone">Cortisol (hydrocortisone)</a></td> <td>Steroidal</td> <td>0.13</td> <td>1.6</td> <td>100</td> <td>76 </td></tr> <tr> <td><a href="/wiki/Cortisone_acetate" title="Cortisone acetate">Cortisone acetate</a></td> <td>Steroidal</td> <td>0.10</td> <td>1.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">Cyproterone acetate</a></td> <td>Steroidal</td> <td>0.10</td> <td>1.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Danazol" title="Danazol">Danazol</a></td> <td>Steroidal</td> <td>18</td> <td>240</td> <td>10</td> <td>6.5 </td></tr> <tr> <td><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Diazoxide" title="Diazoxide">Diazoxide</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Diethylstilbestrol" title="Diethylstilbestrol">Diethylstilbestrol</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Digitoxin" title="Digitoxin">Digitoxin</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Digoxin" title="Digoxin">Digoxin</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Dihydroxyphenylalanine" title="Dihydroxyphenylalanine"><span style="font-size:85%;">DL</span>-DOPA</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Dopamine_(medication)" title="Dopamine (medication)">Dopamine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Enclomiphene" class="mw-redirect" title="Enclomiphene">Enclomiphene</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Epinephrine_(medication)" title="Epinephrine (medication)">Epinephrine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Estradiol_(medication)" title="Estradiol (medication)">Estradiol</a></td> <td>Steroidal</td> <td>49</td> <td>680</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Estradiol_benzoate" title="Estradiol benzoate">Estradiol benzoate</a></td> <td>Steroidal</td> <td>0.70</td> <td>8.6</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">Ethinylestradiol</a></td> <td>Steroidal</td> <td>0.80</td> <td>9.9</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Ethisterone" title="Ethisterone">Ethisterone</a></td> <td>Steroidal</td> <td>55</td> <td>780</td> <td>0.33</td> <td>0.21 </td></tr> <tr> <td><a href="/wiki/Fludrocortisone" title="Fludrocortisone">Fludrocortisone</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td>0.74</td> <td>0.47 </td></tr> <tr> <td><a href="/wiki/Fluoxymesterone" title="Fluoxymesterone">Fluoxymesterone</a></td> <td>Steroidal</td> <td>4.8</td> <td>60</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Flutamide" title="Flutamide">Flutamide</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Homovanillic_acid" title="Homovanillic acid">Homovanillic acid</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Hydrocortisone_hemisuccinate" title="Hydrocortisone hemisuccinate">Hydrocortisone hemisuccinate</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td>8.7</td> <td>5.6 </td></tr> <tr> <td><a href="/wiki/Indometacin" title="Indometacin">Indometacin</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Levonorgestrel" title="Levonorgestrel">Levonorgestrel</a></td> <td>Steroidal</td> <td>31</td> <td>420</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Medroxyprogesterone" title="Medroxyprogesterone">Medroxyprogesterone</a></td> <td>Steroidal</td> <td>0.15</td> <td>1.9</td> <td>13</td> <td>8.1 </td></tr> <tr> <td><a href="/wiki/Medroxyprogesterone_acetate" title="Medroxyprogesterone acetate">Medroxyprogesterone acetate</a></td> <td>Steroidal</td> <td>0.08</td> <td>1.0</td> <td>6.5</td> <td>4.2 </td></tr> <tr> <td><a href="/wiki/Melatonin" title="Melatonin">Melatonin</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Mesterolone" title="Mesterolone">Mesterolone</a></td> <td>Steroidal</td> <td>180</td> <td>3600</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Mestranol" title="Mestranol">Mestranol</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Methoxytryptophol" class="mw-redirect" title="Methoxytryptophol">Methoxytryptophol</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Methyldopa" title="Methyldopa">Methyldopa</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Methylserotonin" title="Methylserotonin">Methylserotonin</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Methyltestosterone" title="Methyltestosterone">Methyltestosterone</a></td> <td>Steroidal</td> <td>39</td> <td>530</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Metiamide" title="Metiamide">Metiamide</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Metribolone" title="Metribolone">Metribolone</a></td> <td>Steroidal</td> <td>1.7</td> <td>21</td> <td>0.36</td> <td>0.23 </td></tr> <tr> <td><a href="/wiki/Metyrapone" title="Metyrapone">Metyrapone</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Mexrenone" title="Mexrenone">Mexrenone</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Nafoxidine" title="Nafoxidine">Nafoxidine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Nandrolone" title="Nandrolone">Nandrolone</a></td> <td>Steroidal</td> <td>5.8</td> <td>72</td> <td>0.10</td> <td>0.63 </td></tr> <tr> <td><a href="/wiki/Norepinephrine_(medication)" title="Norepinephrine (medication)">Norepinephrine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Norethisterone" title="Norethisterone">Norethisterone</a></td> <td>Steroidal</td> <td>11</td> <td>140</td> <td>0.28</td> <td>0.18 </td></tr> <tr> <td><a href="/wiki/Noretynodrel" title="Noretynodrel">Noretynodrel</a></td> <td>Steroidal</td> <td>1.3</td> <td>16</td> <td>0.16</td> <td>0.10 </td></tr> <tr> <td><a href="/wiki/Normetanephrine" title="Normetanephrine">Normetanephrine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Potassium_canrenoate" title="Potassium canrenoate">Potassium canrenoate</a></td> <td>Steroidal</td> <td>0.18</td> <td>2.2</td> <td>0.83</td> <td>0.53 </td></tr> <tr> <td><a href="/wiki/Prednisolone" title="Prednisolone">Prednisolone</a></td> <td>Steroidal</td> <td>0.04</td> <td>0.49</td> <td>59</td> <td>41 </td></tr> <tr> <td><a href="/wiki/Prednisone" title="Prednisone">Prednisone</a></td> <td>Steroidal</td> <td>0.17</td> <td>2.1</td> <td>5.0</td> <td>3.2 </td></tr> <tr> <td><a href="/wiki/Progesterone_(medication)" title="Progesterone (medication)">Progesterone</a></td> <td>Steroidal</td> <td>0.71</td> <td>8.8</td> <td>36</td> <td>24 </td></tr> <tr> <td><a href="/wiki/Promegestone" title="Promegestone">Promegestone</a></td> <td>Steroidal</td> <td>0.007</td> <td>0.09</td> <td>0.40</td> <td>0.25 </td></tr> <tr> <td><a href="/wiki/Prorenone" title="Prorenone">Prorenone</a></td> <td>Steroidal</td> <td>8.2</td> <td>100</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Reserpine" title="Reserpine">Reserpine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Rifampin" class="mw-redirect" title="Rifampin">Rifampin</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Serotonin" title="Serotonin">Serotonin</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Spironolactone" title="Spironolactone">Spironolactone</a></td> <td>Steroidal</td> <td>0.03</td> <td>0.37</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Tamoxifen" title="Tamoxifen">Tamoxifen</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Testolactone" title="Testolactone">Testolactone</a></td> <td>Steroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">Testosterone</a></td> <td>Steroidal</td> <td>100</td> <td>1600</td> <td>8.3</td> <td>5.3 </td></tr> <tr> <td><a href="/wiki/Testosterone_enanthate" title="Testosterone enanthate">Testosterone enanthate</a></td> <td>Steroidal</td> <td>0.007</td> <td>0.086</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td data-sort-value="Thioprogesterone, 7α-"><a href="/wiki/7%CE%B1-Thioprogesterone" title="7α-Thioprogesterone">7α-Thioprogesterone</a></td> <td>Steroidal</td> <td>0.06</td> <td>0.74</td> <td>36</td> <td>24 </td></tr> <tr> <td data-sort-value="Thiospironolactone, 7α-"><a href="/wiki/7%CE%B1-Thiospironolactone" title="7α-Thiospironolactone">7α-Thiospironolactone</a></td> <td>Steroidal</td> <td>0.59</td> <td>7.3</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Thyroxine" class="mw-redirect" title="Thyroxine">Thyroxine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Triiodothyronine" title="Triiodothyronine">Triiodothyronine</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Trimethyltrienolone" title="Trimethyltrienolone">Trimethyltrienolone</a></td> <td>Steroidal</td> <td>0.90</td> <td>11</td> <td>0.11</td> <td>0.07 </td></tr> <tr> <td><a href="/wiki/Vanillylmandelic_acid" title="Vanillylmandelic acid">Vanillylmandelic acid</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Zuclomifene" title="Zuclomifene">Zuclomifene</a></td> <td>Nonsteroidal</td> <td><0.01</td> <td><0.2</td> <td><0.1</td> <td><0.1 </td></tr> <tr class="sortbottom"> <td colspan="6" style="width: 1px;">The reference <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligands</a> (100%) for the <a href="/wiki/Relative_binding_affinity" class="mw-redirect" title="Relative binding affinity"><abbr title="relative binding affinity">RBA</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip relative binding affinity</span> (%) values were <a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">testosterone</a> for SHBG and <a href="/wiki/Hydrocortisone" title="Hydrocortisone">cortisol</a> for <a href="/wiki/Corticosteroid-binding_globulin" class="mw-redirect" title="Corticosteroid-binding globulin"><abbr title="corticosteroid-binding globulin">CBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip corticosteroid-binding globulin</span>. </td></tr></tbody></table> <table class="wikitable center sortable mw-collapsible mw-collapsed" style="width:425px; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption class="nowrap">Affinities of 21 progestins for SHBG and CBG<sup id="cite_ref-pmid16112947_44-1" class="reference"><a href="#cite_note-pmid16112947-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BerginkLoonen1985_47-0" class="reference"><a href="#cite_note-BerginkLoonen1985-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Progestogen</th> <th data-sort-type="number">SHBG (%)</th> <th data-sort-type="number">CBG (%) </th></tr> <tr> <td><a href="/wiki/17%CE%B1-Allyl-19-nortestosterone" title="17α-Allyl-19-nortestosterone">17α-Allyl-19-nortestosterone</a></td> <td><1</td> <td>? </td></tr> <tr> <td><a href="/wiki/Allylestrenol" title="Allylestrenol">Allylestrenol</a></td> <td><1</td> <td>? </td></tr> <tr> <td><a href="/wiki/Chlormadinone_acetate" title="Chlormadinone acetate">Chlormadinone acetate</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">Cyproterone acetate</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Desogestrel" title="Desogestrel">Desogestrel</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Dienogest" title="Dienogest">Dienogest</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Drospirenone" title="Drospirenone">Drospirenone</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Etonogestrel" title="Etonogestrel">Etonogestrel</a></td> <td>15</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Gestodene" title="Gestodene">Gestodene</a></td> <td>40</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Levonorgestrel" title="Levonorgestrel">Levonorgestrel</a></td> <td>50</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Medroxyprogesterone_acetate" title="Medroxyprogesterone acetate">Medroxyprogesterone acetate</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Megestrol_acetate" title="Megestrol acetate">Megestrol acetate</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Nomegestrol_acetate" title="Nomegestrol acetate">Nomegestrol acetate</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Norelgestromin" title="Norelgestromin">Norelgestromin</a></td> <td><1</td> <td>? </td></tr> <tr> <td><a href="/wiki/Norethisterone" title="Norethisterone">Norethisterone</a></td> <td>16</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Noretynodrel" title="Noretynodrel">Noretynodrel</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Norgestimate" title="Norgestimate">Norgestimate</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Progesterone_(medication)" title="Progesterone (medication)">Progesterone</a></td> <td><1</td> <td>36 </td></tr> <tr> <td><a href="/wiki/Promegestone" title="Promegestone">Promegestone</a></td> <td><1</td> <td><1 </td></tr> <tr> <td><a href="/wiki/Segesterone_acetate" title="Segesterone acetate">Segesterone acetate</a></td> <td><1</td> <td>? </td></tr> <tr> <td><a href="/wiki/%CE%944-Tibolone" title="Δ4-Tibolone">Δ<sup>4</sup>-Tibolone</a></td> <td>1</td> <td><1 </td></tr> <tr class="sortbottom"> <td colspan="3" style="width: 1px;">Values are <a href="/wiki/Relative_binding_affinities" class="mw-redirect" title="Relative binding affinities"><abbr title="relative binding affinities">RBAs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip relative binding affinities</span> (%). The reference <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a> (100%) for SHBG was <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a> and for <a href="/wiki/Corticosteroid-binding_globulin" class="mw-redirect" title="Corticosteroid-binding globulin"><abbr title="corticosteroid-binding globulin">CBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip corticosteroid-binding globulin</span> was <a href="/wiki/Cortisol" title="Cortisol">cortisol</a>. </td></tr></tbody></table> <table class="wikitable center sortable mw-collapsible mw-collapsed" style="width:300px; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption class="nowrap">Affinities of 14 <abbr title="androgens/anabolic steroids">AAS</abbr> for SHBG<sup id="cite_ref-pmid6539197_43-1" class="reference"><a href="#cite_note-pmid6539197-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Compound</th> <th data-sort-type="number">SHBG (%) </th></tr> <tr> <td><a href="/wiki/5%CE%B1-Androstane-3%CE%B2,17%CE%B2-diol" class="mw-redirect" title="5α-Androstane-3β,17β-diol">5α-Androstane-3β,17β-diol</a></td> <td>17 </td></tr> <tr> <td><a href="/wiki/5%CE%B2-Androstane-3%CE%B1,17%CE%B2-diol" class="mw-redirect" title="5β-Androstane-3α,17β-diol">5β-Androstane-3α,17β-diol</a></td> <td>5 </td></tr> <tr> <td><a href="/wiki/Androstanolone" title="Androstanolone">Dihydrotestosterone</a></td> <td>100 </td></tr> <tr> <td><a href="/wiki/Ethylestrenol" title="Ethylestrenol">Ethylestrenol</a></td> <td><1 </td></tr> <tr> <td><a href="/wiki/Fluoxymesterone" title="Fluoxymesterone">Fluoxymesterone</a></td> <td><1 </td></tr> <tr> <td><a href="/wiki/Mesterolone" title="Mesterolone">Mesterolone</a></td> <td>440 </td></tr> <tr> <td><a href="/wiki/Metandienone" title="Metandienone">Metandienone</a></td> <td>2 </td></tr> <tr> <td><a href="/wiki/Metenolone" title="Metenolone">Metenolone</a></td> <td>3 </td></tr> <tr> <td><a href="/wiki/Methyltestosterone" title="Methyltestosterone">Methyltestosterone</a></td> <td>5 </td></tr> <tr> <td><a href="/wiki/Metribolone" title="Metribolone">Metribolone</a></td> <td><1 </td></tr> <tr> <td><a href="/wiki/Nandrolone" title="Nandrolone">Nandrolone</a></td> <td>1 </td></tr> <tr> <td><a href="/wiki/Oxymetholone" title="Oxymetholone">Oxymetholone</a></td> <td><1 </td></tr> <tr> <td><a href="/wiki/Stanozolol" title="Stanozolol">Stanozolol</a></td> <td>1 </td></tr> <tr> <td><a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">Testosterone</a></td> <td>19 </td></tr> <tr class="sortbottom"> <td colspan="2" style="width: 1px;">Values are <a href="/wiki/Relative_binding_affinities" class="mw-redirect" title="Relative binding affinities"><abbr title="relative binding affinities">RBAs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip relative binding affinities</span> (%). The reference <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a> (100%) for SHBG was <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a>. </td></tr></tbody></table> <table class="wikitable center sortable mw-collapsible mw-collapsed" style="width:300px; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption class="nowrap">Affinities of 41 steroids for SHBG<sup id="cite_ref-pmid7197818_48-0" class="reference"><a href="#cite_note-pmid7197818-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Compound</th> <th data-sort-type="number">SHBG (%) </th></tr> <tr> <td><a href="/wiki/3%CE%B2-Androstanediol" title="3β-Androstanediol">3β-Androstanediol</a></td> <td>100 </td></tr> <tr> <td><a href="/wiki/Androstenediol" title="Androstenediol">Androstenediol</a></td> <td>77 </td></tr> <tr> <td><a href="/wiki/Bolandiol" title="Bolandiol">Bolandiol</a></td> <td>24 </td></tr> <tr> <td><a href="/wiki/5%CE%B1-Dihydroethisterone" title="5α-Dihydroethisterone">Dihydroethisterone</a></td> <td>100 </td></tr> <tr> <td><a href="/w/index.php?title=5%CE%B1-Dihydroethyltestosterone&action=edit&redlink=1" class="new" title="5α-Dihydroethyltestosterone (page does not exist)">Dihydroethyltestosterone</a></td> <td>18–21 </td></tr> <tr> <td><a href="/w/index.php?title=5%CE%B1-Dihydromethylandrostenediol&action=edit&redlink=1" class="new" title="5α-Dihydromethylandrostenediol (page does not exist)">Dihydromethylandrostenediol</a></td> <td>77 </td></tr> <tr> <td><a href="/wiki/5%CE%B1-Dihydronandrolone" title="5α-Dihydronandrolone">Dihydronandrolone</a></td> <td>44 </td></tr> <tr> <td><a href="/wiki/Androstanolone" title="Androstanolone">Dihydrotestosterone</a></td> <td>100 </td></tr> <tr> <td><a href="/w/index.php?title=5%CE%B1-Dihydrotrestolone&action=edit&redlink=1" class="new" title="5α-Dihydrotrestolone (page does not exist)">Dihydrotrestolone</a></td> <td>47 </td></tr> <tr> <td><a href="/w/index.php?title=4,17%CE%B1-Dimethyltestosterone&action=edit&redlink=1" class="new" title="4,17α-Dimethyltestosterone (page does not exist)">4,17α-Dimethyltestosterone</a></td> <td>97 </td></tr> <tr> <td><a href="/wiki/Drostanolone" title="Drostanolone">Drostanolone</a></td> <td>39 </td></tr> <tr> <td><a href="/wiki/Ethisterone" title="Ethisterone">Ethisterone</a></td> <td>92 </td></tr> <tr> <td><a href="/wiki/Fluoxymesterone" title="Fluoxymesterone">Fluoxymesterone</a></td> <td>3 </td></tr> <tr> <td><a href="/wiki/11-Ketodihydrotestosterone" title="11-Ketodihydrotestosterone">11-Ketodihydrotestosterone</a></td> <td>0 </td></tr> <tr> <td><a href="/wiki/Medroxyprogesterone_acetate" title="Medroxyprogesterone acetate">Medroxyprogesterone acetate</a></td> <td>16 </td></tr> <tr> <td><a href="/wiki/Megestrol_acetate" title="Megestrol acetate">Megestrol acetate</a></td> <td>0 </td></tr> <tr> <td><a href="/wiki/Mestanolone" title="Mestanolone">Mestanolone</a></td> <td>84 </td></tr> <tr> <td><a href="/wiki/Methasterone" title="Methasterone">Methasterone</a></td> <td>58 </td></tr> <tr> <td><a href="/wiki/Methyl-1-testosterone" title="Methyl-1-testosterone">Methyl-1-testosterone</a></td> <td>69 </td></tr> <tr> <td><a href="/wiki/Methylandrostenediol" class="mw-redirect" title="Methylandrostenediol">Methylandrostenediol</a></td> <td>40 </td></tr> <tr> <td><a href="/wiki/Methyltestosterone" title="Methyltestosterone">Methyltestosterone</a></td> <td>64 </td></tr> <tr> <td><a href="/wiki/Mibolerone" title="Mibolerone">Mibolerone</a></td> <td>6 </td></tr> <tr> <td><a href="/wiki/Nandrolone" title="Nandrolone">Nandrolone</a></td> <td>16 </td></tr> <tr> <td><a href="/wiki/Nandrolone_decanoate" title="Nandrolone decanoate">Nandrolone decanoate</a></td> <td>0 </td></tr> <tr> <td><a href="/wiki/Nandrolone_phenylpropionate" title="Nandrolone phenylpropionate">Nandrolone phenylpropionate</a></td> <td>0 </td></tr> <tr> <td><a href="/wiki/Norethandrolone" title="Norethandrolone">Norethandrolone</a></td> <td>3 </td></tr> <tr> <td><a href="/wiki/Norethisterone" title="Norethisterone">Norethisterone</a></td> <td>21 </td></tr> <tr> <td><a href="/wiki/Normethandrone" title="Normethandrone">Normethandrone</a></td> <td>7 </td></tr> <tr> <td><a href="/wiki/Oxandrolone" title="Oxandrolone">Oxandrolone</a></td> <td>0 </td></tr> <tr> <td><a href="/wiki/Oxymetholone" title="Oxymetholone">Oxymetholone</a></td> <td>3 </td></tr> <tr> <td><a href="/wiki/Progesterone_(medication)" title="Progesterone (medication)">Progesterone</a></td> <td>13 </td></tr> <tr> <td><a href="/wiki/Stanozolol" title="Stanozolol">Stanozolol</a></td> <td>36 </td></tr> <tr> <td><a href="/wiki/1-Testosterone" title="1-Testosterone">1-Testosterone</a></td> <td>98 </td></tr> <tr> <td><a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">Testosterone</a></td> <td>82 </td></tr> <tr> <td><a href="/wiki/Testosterone_benzoate" title="Testosterone benzoate">Testosterone benzoate</a></td> <td>8 </td></tr> <tr> <td><a href="/wiki/Testosterone_cypionate" title="Testosterone cypionate">Testosterone cypionate</a></td> <td>6 </td></tr> <tr> <td><a href="/wiki/Testosterone_enanthate" title="Testosterone enanthate">Testosterone enanthate</a></td> <td>9 </td></tr> <tr> <td><a href="/wiki/%CE%944-Tibolone" title="Δ4-Tibolone">Δ<sup>4</sup>-Tibolone</a></td> <td>8 </td></tr> <tr> <td><a href="/wiki/Trestolone" title="Trestolone">Trestolone</a></td> <td>12 </td></tr> <tr> <td><a href="/wiki/Trestolone_enanthate" title="Trestolone enanthate">Trestolone enanthate</a></td> <td>12 </td></tr> <tr> <td><a href="/wiki/Vinyltestosterone" title="Vinyltestosterone">Vinyltestosterone</a></td> <td>36 </td></tr> <tr class="sortbottom"> <td colspan="2" style="width: 1px;">Values are <a href="/wiki/Relative_binding_affinities" class="mw-redirect" title="Relative binding affinities"><abbr title="relative binding affinities">RBAs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip relative binding affinities</span> (%). The reference <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a> (100%) for SHBG was <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a>. </td></tr></tbody></table> <table class="wikitable center sortable mw-collapsible mw-collapsed" style="width:300px; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption class="nowrap">Affinities of 11 steroids for SHBG and CBG<sup id="cite_ref-pmid359134_49-0" class="reference"><a href="#cite_note-pmid359134-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Compound</th> <th><a class="mw-selflink selflink"><abbr title="Sex hormone-binding globulin">SHBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Sex hormone-binding globulin</span> (%)</th> <th><a href="/wiki/Corticosteroid_binding_globulin" class="mw-redirect" title="Corticosteroid binding globulin"><abbr title="Corticosteroid binding globulin">CBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Corticosteroid binding globulin</span> (%) </th></tr> <tr> <td><a href="/wiki/Aldosterone" title="Aldosterone">Aldosterone</a></td> <td><0.2</td> <td>6.0 </td></tr> <tr> <td><a href="/wiki/Corticosterone" title="Corticosterone">Corticosterone</a></td> <td><0.2</td> <td>107 </td></tr> <tr> <td><a href="/wiki/Hydrocortisone" title="Hydrocortisone">Cortisol</a></td> <td><0.2</td> <td>100 </td></tr> <tr> <td><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></td> <td><0.2</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Androstanolone" title="Androstanolone">Dihydrotestosterone</a></td> <td>100</td> <td>0.8 </td></tr> <tr> <td><a href="/wiki/Estradiol_(medication)" title="Estradiol (medication)">Estradiol</a></td> <td>8.7</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Metribolone" title="Metribolone">Metribolone</a></td> <td>0.2</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Moxestrol" title="Moxestrol">Moxestrol</a></td> <td><0.2</td> <td><0.1 </td></tr> <tr> <td><a href="/wiki/Progesterone_(medication)" title="Progesterone (medication)">Progesterone</a></td> <td><0.2</td> <td>25 </td></tr> <tr> <td><a href="/wiki/Promegestone" title="Promegestone">Promegestone</a></td> <td><0.2</td> <td>0.9 </td></tr> <tr> <td><a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">Testosterone</a></td> <td>26</td> <td>3 </td></tr> <tr class="sortbottom"> <td colspan="9" style="width: 1px;">Values are <a href="/wiki/Relative_binding_affinities" class="mw-redirect" title="Relative binding affinities"><abbr title="relative binding affinities">RBAs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip relative binding affinities</span> (%). The reference <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a> (100%) for SHBG was <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a> and for <a href="/wiki/Corticosteroid-binding_globulin" class="mw-redirect" title="Corticosteroid-binding globulin"><abbr title="corticosteroid-binding globulin">CBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip corticosteroid-binding globulin</span> was <a href="/wiki/Cortisol" title="Cortisol">cortisol</a>. </td></tr></tbody></table> <table class="wikitable sortable mw-collapsible mw-collapsed" style="width:500px; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption class="nowrap">Affinities of 9 estrogens for SHBG<sup id="cite_ref-pmid16112947_44-2" class="reference"><a href="#cite_note-pmid16112947-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-LemkeWilliams2008_50-0" class="reference"><a href="#cite_note-LemkeWilliams2008-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <th>Compound</th> <th data-sort-type="number"><a href="/wiki/Relative_binding_affinity" class="mw-redirect" title="Relative binding affinity"><abbr title="Relative binding affinity">RBA</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Relative binding affinity</span> to<br /><a class="mw-selflink selflink"><abbr title="sex hormone-binding globulin">SHBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip sex hormone-binding globulin</span> (%)</th> <th data-sort-type="number">Bound to<br /><abbr title="sex hormone-binding globulin">SHBG</abbr> (%)</th> <th data-sort-type="number">Bound to<br /><a href="/wiki/Human_serum_albumin" title="Human serum albumin">albumin</a> (%) </th></tr> <tr> <td><a href="/wiki/Estradiol_(medication)" title="Estradiol (medication)">17β-Estradiol</a></td> <td>50</td> <td>37</td> <td>61 </td></tr> <tr> <td><a href="/wiki/Estrone_(medication)" title="Estrone (medication)">Estrone</a></td> <td>12</td> <td>16</td> <td>80 </td></tr> <tr> <td><a href="/wiki/Estriol_(medication)" title="Estriol (medication)">Estriol</a></td> <td>0.3</td> <td>1</td> <td>91 </td></tr> <tr> <td><a href="/wiki/Estrone_sulfate_(medication)" title="Estrone sulfate (medication)">Estrone sulfate</a></td> <td>0</td> <td>0</td> <td>99 </td></tr> <tr> <td><a href="/wiki/17%CE%B2-Dihydroequilin" title="17β-Dihydroequilin">17β-Dihydroequilin</a></td> <td>30</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Equilin" title="Equilin">Equilin</a></td> <td>8</td> <td>26</td> <td>13 </td></tr> <tr> <td><a href="/wiki/17%CE%B2-Dihydroequilin_sulfate" class="mw-redirect" title="17β-Dihydroequilin sulfate">17β-Dihydroequilin sulfate</a></td> <td>0</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/Equilin_sulfate" class="mw-redirect" title="Equilin sulfate">Equilin sulfate</a></td> <td>0</td> <td>?</td> <td>? </td></tr> <tr> <td><a href="/wiki/8,9-Dehydroestrone" title="8,9-Dehydroestrone">Δ<sup>8</sup>-Estrone</a></td> <td>?</td> <td>?</td> <td>? </td></tr> <tr class="sortbottom"> <td colspan="4" style="width: 1px;">The reference <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a> (100%) for the SHBG <a href="/wiki/Relative_binding_affinity" class="mw-redirect" title="Relative binding affinity"><abbr title="relative binding affinity">RBA</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip relative binding affinity</span> (%) values was <a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">testosterone</a>. </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Endogenous_steroids">Endogenous steroids</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=16" title="Edit section: Endogenous steroids"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Measurement">Measurement</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=17" title="Edit section: Measurement"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>When checking serum estradiol or testosterone, a total level that includes free and bound fractions can be assayed, or the free portion may be measured alone. Sex hormone-binding globulin can be measured separately from the total fraction of testosterone. </p><p>A <a href="/wiki/Free_androgen_index" title="Free androgen index">free androgen index</a> expresses the ratio of testosterone to SHBG and can be used to summarize the activity of free testosterone. </p> <div class="mw-heading mw-heading3"><h3 id="Affinity_and_binding">Affinity and binding</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=18" title="Edit section: Affinity and binding"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <table class="wikitable center sortable mw-collapsible mw-collapsed" style="width:100%; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption class="nowrap"><span style="font-size:105%;">Affinities of endogenous steroids for SHBG and plasma protein binding<sup id="cite_ref-pmid7195404_51-0" class="reference"><a href="#cite_note-pmid7195404-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup></span> </caption> <tbody><tr> <th rowspan="2">Steroid</th> <th colspan="2">SHBG affinity</th> <th colspan="5">Plasma protein binding in men</th> <th colspan="5">Plasma protein binding in women (follicular phase) </th></tr> <tr> <th><abbr title="Relative binding affinity">RBA</abbr> (%)</th> <th>K (10<sup>6</sup> M<sup>−1</sup>)</th> <th>Total (nM)</th> <th>Unbound (%)</th> <th>SHBG (%)</th> <th>CBG (%)</th> <th>Albumin (%)</th> <th>Total (nM)</th> <th>Unbound (%)</th> <th>SHBG (%)</th> <th>CBG (%)</th> <th>Albumin (%) </th></tr> <tr> <td><a href="/wiki/Aldosterone" title="Aldosterone">Aldosterone</a></td> <td>0.017</td> <td>0.21</td> <td>0.35</td> <td>37.1</td> <td>0.10</td> <td>21.2</td> <td>41.6</td> <td>0.24</td> <td>36.8</td> <td>0.23</td> <td>21.9</td> <td>41.2 </td></tr> <tr> <td data-sort-value="Androstanediol, 3α-"><a href="/wiki/3%CE%B1-Androstanediol" title="3α-Androstanediol">3α-Androstanediol</a></td> <td>82</td> <td>1300</td> <td>0.41</td> <td>0.85</td> <td>13.7</td> <td data-sort-value="0"><0.1</td> <td>85.5</td> <td>0.068</td> <td>0.71</td> <td>27.9</td> <td data-sort-value="0"><0.1</td> <td>71.4 </td></tr> <tr> <td><a href="/wiki/Androstenediol" title="Androstenediol">Androstenediol</a></td> <td>97</td> <td>1500</td> <td>4.3</td> <td>3.24</td> <td>60.4</td> <td data-sort-value="0"><0.1</td> <td>36.3</td> <td>2.4</td> <td>1.73</td> <td>78.8</td> <td data-sort-value="0"><0.1</td> <td>19.4 </td></tr> <tr> <td><a href="/wiki/Androstenedione" title="Androstenedione">Androstenedione</a></td> <td>2.3</td> <td>29</td> <td>4.1</td> <td>7.85</td> <td>2.82</td> <td>1.37</td> <td>88.0</td> <td>5.4</td> <td>7.54</td> <td>6.63</td> <td>1.37</td> <td>84.5 </td></tr> <tr> <td><a href="/wiki/Androsterone" title="Androsterone">Androsterone</a></td> <td>1.1</td> <td>14</td> <td>2.0</td> <td>4.22</td> <td>0.73</td> <td>0.52</td> <td>94.5</td> <td>1.5</td> <td>4.18</td> <td>1.77</td> <td>0.54</td> <td>93.5 </td></tr> <tr> <td><a href="/wiki/Corticosterone" title="Corticosterone">Corticosterone</a></td> <td>0.18</td> <td>2.2</td> <td>12</td> <td>3.39</td> <td>0.09</td> <td>77.5</td> <td>19.0</td> <td>7.0</td> <td>3.28</td> <td>0.22</td> <td>78.1</td> <td>18.4 </td></tr> <tr> <td><a href="/wiki/Cortisol" title="Cortisol">Cortisol</a></td> <td>0.13</td> <td>1.6</td> <td>400</td> <td>3.91</td> <td>0.08</td> <td>89.5</td> <td>6.57</td> <td>400</td> <td>3.77</td> <td>0.18</td> <td>89.7</td> <td>6.33 </td></tr> <tr> <td><a href="/wiki/Cortisone" title="Cortisone">Cortisone</a></td> <td>0.22</td> <td>2.7</td> <td>72</td> <td>16.2</td> <td>0.54</td> <td>38.0</td> <td>45.3</td> <td>54</td> <td>15.8</td> <td>1.30</td> <td>38.6</td> <td>44.3 </td></tr> <tr> <td><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">Dehydroepiandrosterone</a></td> <td>5.3</td> <td>66</td> <td>24</td> <td>4.13</td> <td>3.38</td> <td data-sort-value="0"><0.1</td> <td>92.4</td> <td>17</td> <td>3.93</td> <td>7.88</td> <td data-sort-value="0"><0.1</td> <td>88.1 </td></tr> <tr> <td data-sort-value="Deoxycorticosterone, 11-"><a href="/wiki/11-Deoxycorticosterone" title="11-Deoxycorticosterone">11-Deoxycorticosterone</a></td> <td>1.9</td> <td>24</td> <td>0.20</td> <td>2.69</td> <td>0.80</td> <td>36.4</td> <td>60.1</td> <td>0.12</td> <td>2.62</td> <td>1.91</td> <td>36.9</td> <td>58.6 </td></tr> <tr> <td data-sort-value="Deoxycortisol, 11-"><a href="/wiki/11-Deoxycortisol" title="11-Deoxycortisol">11-Deoxycortisol</a></td> <td>1.3</td> <td>16</td> <td>1.4</td> <td>3.37</td> <td>0.67</td> <td>77.1</td> <td>18.9</td> <td>0.60</td> <td>3.24</td> <td>1.57</td> <td>77.1</td> <td>18.1 </td></tr> <tr> <td><a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">Dihydrotestosterone</a></td> <td>220</td> <td>5500</td> <td>1.7</td> <td>0.88</td> <td>59.7</td> <td>0.22</td> <td>39.2</td> <td>0.65</td> <td>0.47</td> <td>78.4</td> <td>0.12</td> <td>21.0 </td></tr> <tr> <td><a href="/wiki/Estradiol" title="Estradiol">Estradiol</a></td> <td>49</td> <td>680</td> <td>0.084</td> <td>2.32</td> <td>19.6</td> <td data-sort-value="0"><0.1</td> <td>78.0</td> <td>0.29</td> <td>1.81</td> <td>37.3</td> <td data-sort-value="0"><0.1</td> <td>60.8 </td></tr> <tr> <td><a href="/wiki/Estriol" title="Estriol">Estriol</a></td> <td>0.35</td> <td>4.3</td> <td>0.037</td> <td>8.15</td> <td>0.44</td> <td data-sort-value="0"><0.2</td> <td>91.3</td> <td>0.10</td> <td>8.10</td> <td>1.06</td> <td data-sort-value="0"><0.2</td> <td>90.7 </td></tr> <tr> <td><a href="/wiki/Estrone" title="Estrone">Estrone</a></td> <td>12</td> <td>150</td> <td>0.081</td> <td>3.96</td> <td>7.37</td> <td data-sort-value="0"><0.1</td> <td>88.6</td> <td>0.23</td> <td>3.58</td> <td>16.3</td> <td data-sort-value="0"><0.1</td> <td>80.1 </td></tr> <tr> <td><a href="/wiki/Etiocholanolone" title="Etiocholanolone">Etiocholanolone</a></td> <td>0.11</td> <td>1.4</td> <td>1.3</td> <td>8.15</td> <td>0.14</td> <td>0.44</td> <td>91.3</td> <td>1.2</td> <td>8.13</td> <td>0.35</td> <td>0.46</td> <td>91.1 </td></tr> <tr> <td><a href="/wiki/Pregnenolone" title="Pregnenolone">Pregnenolone</a></td> <td>1.1</td> <td>14</td> <td>2.4</td> <td>2.87</td> <td>0.50</td> <td>0.16</td> <td>96.5</td> <td>2.2</td> <td>2.85</td> <td>1.21</td> <td>0.16</td> <td>95.8 </td></tr> <tr> <td data-sort-value="Pregnenolone, 17α-Hydroxy"><a href="/wiki/17%CE%B1-Hydroxypregnenolone" title="17α-Hydroxypregnenolone">17α-Hydroxypregnenolone</a></td> <td>0.19</td> <td>2.3</td> <td>5.4</td> <td>4.27</td> <td>0.12</td> <td data-sort-value="0"><0.1</td> <td>95.5</td> <td>3.5</td> <td>4.26</td> <td>0.30</td> <td data-sort-value="0"><0.1</td> <td>95.4 </td></tr> <tr> <td><a href="/wiki/Progesterone" title="Progesterone">Progesterone</a></td> <td>0.71</td> <td>8.8</td> <td>0.57</td> <td>2.39</td> <td>0.26</td> <td>17.2</td> <td>80.1</td> <td>0.65</td> <td>2.36</td> <td>0.63</td> <td>17.7</td> <td>79.3 </td></tr> <tr> <td data-sort-value="Progesterone, 17α-Hydroxy"><a href="/wiki/17%CE%B1-Hydroxyprogesterone" title="17α-Hydroxyprogesterone">17α-Hydroxyprogesterone</a></td> <td>0.8</td> <td>9.9</td> <td>5.4</td> <td>2.50</td> <td>0.31</td> <td>41.3</td> <td>55.9</td> <td>1.8</td> <td>2.44</td> <td>0.73</td> <td>42.1</td> <td>54.7 </td></tr> <tr> <td><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></td> <td>100</td> <td>1600</td> <td>23</td> <td>2.23</td> <td>44.3</td> <td>3.56</td> <td>49.9</td> <td>1.3</td> <td>1.36</td> <td>66.0</td> <td>2.26</td> <td>30.4 </td></tr> <tr class="sortbottom"> <td colspan="13" style="width: 1px;">In men, the concentrations of SHBG, CBG, and albumin were 28 nM, 0.7 μM, and 0.56 mM, respectively. In women, the concentrations of SHBG, CBG, and albumin were 37 nM, 0.7 μM, and 0.56 mM, respectively. </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Synonyms">Synonyms</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=19" title="Edit section: Synonyms"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>SHBG has been known under a variety of different names including:<sup id="cite_ref-GeneCards_52-0" class="reference"><a href="#cite_note-GeneCards-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Westphal2012_53-0" class="reference"><a href="#cite_note-Westphal2012-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AcademicPress1994_54-0" class="reference"><a href="#cite_note-AcademicPress1994-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup> </p> <ul><li>Sex hormone-binding globulin (SHBG)</li> <li>Sex steroid-binding globulin (SSBG, SBG)</li> <li>Sex steroid-binding protein (SBP, SSBP)</li> <li>Androgen-binding protein (ABP)</li> <li>Estradiol-binding-protein (EBP)</li> <li>Testosterone–estradiol binding globulin (TeBG, TEBG)</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=20" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist 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Lippincott Williams & Wilkins. pp. 1306–. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-7817-6879-5" title="Special:BookSources/978-0-7817-6879-5"><bdi>978-0-7817-6879-5</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Foye%27s+Principles+of+Medicinal+Chemistry&rft.pages=1306-&rft.pub=Lippincott+Williams+%26+Wilkins&rft.date=2008&rft.isbn=978-0-7817-6879-5&rft.aulast=Lemke&rft.aufirst=TL&rft.au=Williams%2C+DA&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DR0W1ErpsQpkC%26pg%3DPA1306&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASex+hormone-binding+globulin" class="Z3988"></span></span> </li> <li id="cite_note-pmid7195404-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid7195404_51-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDunnNisulaRodbard1981" class="citation journal cs1">Dunn JF, Nisula BC, Rodbard D (July 1981). "Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma". <i>J. Clin. Endocrinol. Metab</i>. <b>53</b> (1): 58–68. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fjcem-53-1-58">10.1210/jcem-53-1-58</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7195404">7195404</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J.+Clin.+Endocrinol.+Metab.&rft.atitle=Transport+of+steroid+hormones%3A+binding+of+21+endogenous+steroids+to+both+testosterone-binding+globulin+and+corticosteroid-binding+globulin+in+human+plasma&rft.volume=53&rft.issue=1&rft.pages=58-68&rft.date=1981-07&rft_id=info%3Adoi%2F10.1210%2Fjcem-53-1-58&rft_id=info%3Apmid%2F7195404&rft.aulast=Dunn&rft.aufirst=JF&rft.au=Nisula%2C+BC&rft.au=Rodbard%2C+D&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASex+hormone-binding+globulin" class="Z3988"></span></span> </li> <li id="cite_note-GeneCards-52"><span class="mw-cite-backlink"><b><a href="#cite_ref-GeneCards_52-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SHBG">"SHBG"</a>. <i>GeneCards</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=GeneCards&rft.atitle=SHBG&rft_id=https%3A%2F%2Fwww.genecards.org%2Fcgi-bin%2Fcarddisp.pl%3Fgene%3DSHBG&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASex+hormone-binding+globulin" class="Z3988"></span></span> </li> <li id="cite_note-Westphal2012-53"><span class="mw-cite-backlink"><b><a href="#cite_ref-Westphal2012_53-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://books.google.com/books?id=3DD6CAAAQBAJ&pg=PA198">"Sex Steroid-Binding Protein"</a>. <i>Steroid-Protein Interactions II</i>. Springer Science & Business Media. 6 December 2012. p. 198. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-3-642-82486-9" title="Special:BookSources/978-3-642-82486-9"><bdi>978-3-642-82486-9</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Sex+Steroid-Binding+Protein&rft.btitle=Steroid-Protein+Interactions+II&rft.pages=198&rft.pub=Springer+Science+%26+Business+Media&rft.date=2012-12-06&rft.isbn=978-3-642-82486-9&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3D3DD6CAAAQBAJ%26pg%3DPA198&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASex+hormone-binding+globulin" class="Z3988"></span></span> </li> <li id="cite_note-AcademicPress1994-54"><span class="mw-cite-backlink"><b><a href="#cite_ref-AcademicPress1994_54-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLitwackWestphal1994" class="citation book cs1">Litwack G, Westphal U, eds. (12 December 1994). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=ZBUjEoJu1MIC&pg=PA200">"Structure, Function, and Regulation of Androgen-Binding Protein?Sex Hormone-Binding Globulin"</a>. <i>Vitamins and Hormones: Steroids</i>. Academic Press. p. 200. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-08-086646-8" title="Special:BookSources/978-0-08-086646-8"><bdi>978-0-08-086646-8</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Structure%2C+Function%2C+and+Regulation+of+Androgen-Binding+Protein%3FSex+Hormone-Binding+Globulin&rft.btitle=Vitamins+and+Hormones%3A+Steroids&rft.pages=200&rft.pub=Academic+Press&rft.date=1994-12-12&rft.isbn=978-0-08-086646-8&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DZBUjEoJu1MIC%26pg%3DPA200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASex+hormone-binding+globulin" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=21" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 33em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRosnerHrybKhanNakhla1999" class="citation journal cs1">Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA (1999). "Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane". <i>The Journal of Steroid Biochemistry and Molecular Biology</i>. <b>69</b> (1–6): 481–5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0960-0760%2899%2900070-9">10.1016/S0960-0760(99)00070-9</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10419028">10419028</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6499033">6499033</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Steroid+Biochemistry+and+Molecular+Biology&rft.atitle=Sex+hormone-binding+globulin+mediates+steroid+hormone+signal+transduction+at+the+plasma+membrane&rft.volume=69&rft.issue=1%E2%80%936&rft.pages=481-5&rft.date=1999&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6499033%23id-name%3DS2CID&rft_id=info%3Apmid%2F10419028&rft_id=info%3Adoi%2F10.1016%2FS0960-0760%2899%2900070-9&rft.aulast=Rosner&rft.aufirst=W&rft.au=Hryb%2C+DJ&rft.au=Khan%2C+MS&rft.au=Nakhla%2C+AM&rft.au=Romas%2C+NA&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASex+hormone-binding+globulin" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPowerBocchinfusoPallesenWarmels-Rodenhiser1992" class="citation journal cs1">Power SG, Bocchinfuso WP, Pallesen M, Warmels-Rodenhiser S, Van Baelen H, Hammond GL (October 1992). 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Retrieved <span class="nowrap">13 July</span> 2014</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=SHBG+-+SNPedia&rft.date=2011&rft.au=Trkiehl&rft_id=http%3A%2F%2Fwww.snpedia.com%2Findex.php%2FSHBG&rfr_id=info%3Asid%2Fen.wikipedia.org%3ASex+hormone-binding+globulin" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Sex_hormone-binding_globulin&action=edit&section=22" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P04278">P04278</a></i> (Sex hormone-binding globulin) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Androgen-Binding+Protein">Androgen-Binding+Protein</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a> <a href="/wiki/Gene" title="Gene">Gene</a> <small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000129214">ref</a></small> <a href="/wiki/Protein" title="Protein">Protein</a> <small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/protview?db=core;peptide=ENSG00000129214">ref</a></small></li></ul> <div class="navbox-styles"><style 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nochecker" style="line-height:130%"> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1d2s_EBI.jpg" class="mw-file-description" title="1d2s: CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE"><img alt="1d2s: CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/PDB_1d2s_EBI.jpg/180px-PDB_1d2s_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/PDB_1d2s_EBI.jpg/270px-PDB_1d2s_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/91/PDB_1d2s_EBI.jpg/360px-PDB_1d2s_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1d2s</b>: CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1f5f_EBI.jpg" class="mw-file-description" title="1f5f: CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC"><img alt="1f5f: CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/27/PDB_1f5f_EBI.jpg/180px-PDB_1f5f_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/27/PDB_1f5f_EBI.jpg/270px-PDB_1f5f_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/27/PDB_1f5f_EBI.jpg/360px-PDB_1f5f_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1f5f</b>: CRYSTAL STRUCTURE OF THE N-TERMINAL G-DOMAIN OF SHBG IN COMPLEX WITH ZINC</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1kdk_EBI.jpg" class="mw-file-description" title="1kdk: THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA"><img alt="1kdk: THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PDB_1kdk_EBI.jpg/180px-PDB_1kdk_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PDB_1kdk_EBI.jpg/270px-PDB_1kdk_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ec/PDB_1kdk_EBI.jpg/360px-PDB_1kdk_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1kdk</b>: THE STRUCTURE OF THE N-TERMINAL LG DOMAIN OF SHBG IN CRYSTALS SOAKED WITH EDTA</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1kdm_EBI.jpg" class="mw-file-description" title="1kdm: THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM)"><img alt="1kdm: THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PDB_1kdm_EBI.jpg/180px-PDB_1kdm_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PDB_1kdm_EBI.jpg/270px-PDB_1kdm_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PDB_1kdm_EBI.jpg/360px-PDB_1kdm_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1kdm</b>: THE CRYSTAL STRUCTURE OF THE HUMAN SEX HORMONE-BINDING GLOBULIN (TETRAGONAL CRYSTAL FORM)</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1lhn_EBI.jpg" class="mw-file-description" title="1lhn: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL"><img alt="1lhn: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/PDB_1lhn_EBI.jpg/180px-PDB_1lhn_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/01/PDB_1lhn_EBI.jpg/270px-PDB_1lhn_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/01/PDB_1lhn_EBI.jpg/360px-PDB_1lhn_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1lhn</b>: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17ALPHA-DIOL</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1lho_EBI.jpg" class="mw-file-description" title="1lho: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL"><img alt="1lho: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_1lho_EBI.jpg/180px-PDB_1lho_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_1lho_EBI.jpg/270px-PDB_1lho_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_1lho_EBI.jpg/360px-PDB_1lho_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1lho</b>: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 5ALPHA-ANDROSTANE-3BETA,17BETA-DIOL</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1lhu_EBI.jpg" class="mw-file-description" title="1lhu: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL"><img alt="1lhu: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/PDB_1lhu_EBI.jpg/180px-PDB_1lhu_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/PDB_1lhu_EBI.jpg/270px-PDB_1lhu_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e4/PDB_1lhu_EBI.jpg/360px-PDB_1lhu_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1lhu</b>: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH ESTRADIOL</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1lhv_EBI.jpg" class="mw-file-description" title="1lhv: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH NORGESTREL"><img alt="1lhv: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH NORGESTREL" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/PDB_1lhv_EBI.jpg/180px-PDB_1lhv_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/PDB_1lhv_EBI.jpg/270px-PDB_1lhv_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/ca/PDB_1lhv_EBI.jpg/360px-PDB_1lhv_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1lhv</b>: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH NORGESTREL</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1lhw_EBI.jpg" class="mw-file-description" title="1lhw: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL"><img alt="1lhw: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cb/PDB_1lhw_EBI.jpg/180px-PDB_1lhw_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cb/PDB_1lhw_EBI.jpg/270px-PDB_1lhw_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cb/PDB_1lhw_EBI.jpg/360px-PDB_1lhw_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1lhw</b>: CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Proteins:_carrier_proteins" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Carrier_proteins" title="Template:Carrier proteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Carrier_proteins" title="Template talk:Carrier proteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Carrier_proteins" title="Special:EditPage/Template:Carrier proteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Proteins:_carrier_proteins" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Proteins</a>: <a href="/wiki/Carrier_protein" class="mw-redirect" title="Carrier protein">carrier proteins</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Fatty_acid-binding_protein" title="Fatty acid-binding protein">Fatty acid</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FABP1" title="FABP1">FABP1</a></li> <li><a href="/wiki/FABP2" title="FABP2">FABP2</a></li> <li><a href="/wiki/Heart-type_fatty_acid_binding_protein" title="Heart-type fatty acid binding protein">FABP3</a></li> <li><a href="/wiki/Adipocyte_protein_2" title="Adipocyte protein 2">FABP4</a></li> <li><a href="/wiki/FABP5" title="FABP5">FABP5</a></li> <li><a href="/wiki/FABP6" title="FABP6">FABP6</a></li> <li><a href="/wiki/FABP7" title="FABP7">FABP7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Hormone</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Peptide_hormone" title="Peptide hormone">peptide hormone</a>: <a href="/wiki/Follistatin" title="Follistatin">Follistatin</a></li> <li><a href="/wiki/Growth_hormone-binding_protein" title="Growth hormone-binding protein">Growth hormone binding protein</a></li> <li><a href="/wiki/Insulin-like_growth_factor-binding_protein" title="Insulin-like growth factor-binding protein">Insulin-like growth factor binding protein</a> <ul><li><a href="/wiki/IGFBP1" title="IGFBP1">IGFBP1</a></li> <li><a href="/wiki/IGFBP2" title="IGFBP2">IGFBP2</a></li> <li><a href="/wiki/IGFBP3" title="IGFBP3">IGFBP3</a></li> <li><a href="/wiki/IGFBP4" title="IGFBP4">IGFBP4</a></li> <li><a href="/wiki/IGFBP5" title="IGFBP5">IGFBP5</a></li> <li><a href="/wiki/IGFBP6" title="IGFBP6">IGFBP6</a></li> <li><a href="/wiki/IGFBP7" title="IGFBP7">IGFBP7</a></li></ul></li> <li><a href="/wiki/Neurophysins" title="Neurophysins">Neurophysins</a> <ul><li><a href="/wiki/Neurophysin_I" title="Neurophysin I">Neurophysin I</a></li> <li><a href="/wiki/Neurophysin_II" title="Neurophysin II">II</a></li></ul></li></ul> <ul><li><a href="/wiki/Steroid_hormone" title="Steroid hormone">steroid hormone</a>: <a class="mw-selflink selflink">Sex hormone binding globulin</a>/<a href="/wiki/Androgen-binding_protein" class="mw-redirect" title="Androgen-binding protein">Androgen binding protein</a></li> <li><a href="/wiki/Transcortin" title="Transcortin">Transcortin</a></li> <li><a href="/wiki/Thyroxine-binding_globulin" title="Thyroxine-binding globulin">Thyroxine-binding globulin</a></li> <li><a href="/wiki/Transthyretin" title="Transthyretin">Transthyretin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Metal/element</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>calcium</i> <ul><li><a href="/wiki/Calcium-binding_protein" title="Calcium-binding protein">Calcium-binding protein</a></li> <li><a href="/wiki/Calmodulin-binding_proteins" title="Calmodulin-binding proteins">Calmodulin-binding proteins</a></li></ul></li> <li><i>copper</i> <ul><li><a href="/wiki/Ceruloplasmin" title="Ceruloplasmin">Ceruloplasmin</a></li></ul></li> <li><i>iron</i> <ul><li><a href="/wiki/Iron-binding_proteins" title="Iron-binding proteins">Iron-binding proteins</a></li> <li><a href="/wiki/Transferrin_receptor" title="Transferrin receptor">Transferrin receptor</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Vitamin</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinol_binding_protein" class="mw-redirect" title="Retinol binding protein">Retinol binding protein</a> <ul><li><a href="/wiki/RBP1" title="RBP1">1</a></li> <li><a href="/wiki/RBP2" title="RBP2">2</a></li> <li><a href="/wiki/RBP3" title="RBP3">3</a></li> <li><a href="/wiki/Retinol_binding_protein_4" title="Retinol binding protein 4">4</a></li></ul></li> <li><a href="/wiki/Transcobalamin" title="Transcobalamin">Transcobalamin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Biological_pigment" title="Biological pigment">Pigment</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Light-harvesting_complexes_of_green_plants" title="Light-harvesting complexes of green plants">Plant Light-Harvesting Complex</a></li> <li><a href="/wiki/Orange_carotenoid_N-terminal_domain" title="Orange carotenoid N-terminal domain">Orange Carotenoid Protein</a></li> <li><a href="/wiki/Phycobiliprotein" title="Phycobiliprotein">Phycobiliprotein</a></li> <li><a href="/wiki/Photosynthetic_reaction_centre_protein_family" title="Photosynthetic reaction centre protein family">Photosynthetic Reaction Centers</a></li> <li><a href="/wiki/Phytochrome" title="Phytochrome">Phytochrome</a></li> <li><a href="/wiki/Rhodopsin" title="Rhodopsin">Rhodopsin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acyl_carrier_protein" title="Acyl carrier protein">Acyl carrier protein</a></li> <li><a href="/wiki/Signal_transducing_adaptor_protein" title="Signal transducing adaptor protein">Adaptor protein</a></li> <li><a href="/wiki/Cholesterylester_transfer_protein" class="mw-redirect" title="Cholesterylester transfer protein">Cholesterylester transfer protein</a></li> <li><a href="/wiki/F-box_protein" title="F-box protein">F-box protein</a></li> <li><a href="/wiki/G_protein" title="G protein">GTP-binding protein</a></li> <li><a href="/wiki/Latent_TGF-beta_binding_protein" title="Latent TGF-beta binding protein">Latent TGF-beta binding protein</a></li> <li><a href="/wiki/Major_urinary_proteins" title="Major urinary proteins">Major urinary proteins</a></li> <li><a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">Membrane transport protein</a></li> <li><a href="/wiki/Odorant_binding_protein" class="mw-redirect" title="Odorant binding protein">Odorant binding protein</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style></div><div role="navigation" class="navbox" aria-labelledby="Globular_proteins" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Globular_proteins" title="Template:Globular proteins"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Globular_proteins" title="Template talk:Globular proteins"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Globular_proteins" title="Special:EditPage/Template:Globular proteins"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Globular_proteins" style="font-size:114%;margin:0 4em"><a href="/wiki/Globular_protein" title="Globular protein">Globular proteins</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Blood_plasma" title="Blood plasma">Serum</a> <a href="/wiki/Globulin" title="Globulin">globulins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Alpha_globulin" title="Alpha globulin">Alpha globulins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><span class="nobold"><a href="/wiki/Serpin" title="Serpin">serpins</a>:</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha_globulin#Alpha_1_globulins" title="Alpha globulin">alpha-1</a> (<a href="/wiki/Alpha_1-antichymotrypsin" title="Alpha 1-antichymotrypsin">Alpha 1-antichymotrypsin</a>, <a href="/wiki/Alpha_1-antitrypsin" class="mw-redirect" title="Alpha 1-antitrypsin">Alpha 1-antitrypsin</a>)</li> <li><a href="/wiki/Alpha_globulin#Alpha_2_globulins" title="Alpha globulin">alpha-2</a> (<a href="/wiki/Alpha_2-antiplasmin" title="Alpha 2-antiplasmin">Alpha 2-antiplasmin</a>)</li> <li><a href="/wiki/Antithrombin" title="Antithrombin">Antithrombin</a> (<a href="/wiki/Heparin_cofactor_II" title="Heparin cofactor II">Heparin cofactor II</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><span class="nobold"><a href="/wiki/Carrier_protein" class="mw-redirect" title="Carrier protein">carrier proteins</a>:</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>alpha-1 (<a href="/wiki/Transcortin" title="Transcortin">Transcortin</a>)</li> <li>alpha-2 (<a href="/wiki/Ceruloplasmin" title="Ceruloplasmin">Ceruloplasmin</a>)</li> <li><a href="/wiki/Retinol_binding_protein" class="mw-redirect" title="Retinol binding protein">Retinol binding protein</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><span class="nobold">other:</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>alpha-1 (<a href="/wiki/Orosomucoid" title="Orosomucoid">Orosomucoid</a>)</li> <li>alpha-2 (<a href="/wiki/Alpha-2-Macroglobulin" title="Alpha-2-Macroglobulin">alpha-2-Macroglobulin</a>, <a href="/wiki/Haptoglobin" title="Haptoglobin">Haptoglobin</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Beta_globulins" class="mw-redirect" title="Beta globulins">Beta globulins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><span class="nobold"><a href="/wiki/Carrier_protein" class="mw-redirect" title="Carrier protein">carrier proteins</a>:</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Sex hormone-binding globulin</a></li> <li><a href="/wiki/Transferrin" title="Transferrin">Transferrin</a><br /></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><span class="nobold">other:</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Angiostatin" title="Angiostatin">Angiostatin</a></li> <li><a href="/wiki/Hemopexin" title="Hemopexin">Hemopexin</a></li> <li><a href="/wiki/Beta-2_microglobulin" title="Beta-2 microglobulin">Beta-2 microglobulin</a></li> <li><a href="/wiki/Factor_H" title="Factor H">Factor H</a></li> <li><a href="/wiki/Plasmin" title="Plasmin">Plasminogen</a></li> <li><a href="/wiki/Properdin" title="Properdin">Properdin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Gamma_globulin" title="Gamma globulin">Gamma globulin</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Antibody" title="Antibody">Immunoglobulins</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibronectin" title="Fibronectin">Fibronectin</a> (fFN: <a href="/wiki/Fetal_fibronectin" title="Fetal fibronectin">Fetal fibronectin</a>)</li> <li><a href="/wiki/Macroglobulin" title="Macroglobulin">Macroglobulin</a>/<a href="/wiki/Microglobulin" title="Microglobulin">Microglobulin</a></li> <li><a href="/wiki/Transcobalamin" title="Transcobalamin">Transcobalamin</a></li> <li><a href="/wiki/Edestin" title="Edestin">Edestin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other globulins</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beta-lactoglobulin" class="mw-redirect" title="Beta-lactoglobulin">Beta-lactoglobulin</a> <ul><li><a href="/wiki/Lactoferrin" title="Lactoferrin">Lactoferrin</a></li></ul></li> <li><a href="/wiki/Thyroglobulin" title="Thyroglobulin">Thyroglobulin</a></li> <li><a href="/wiki/Alpha-lactalbumin" class="mw-redirect" title="Alpha-lactalbumin">Alpha-lactalbumin</a></li> <li><a href="/wiki/11S_globulin_family" title="11S globulin family">11S globulin family</a></li> <li><a href="/w/index.php?title=7S_seed_storage_protein&action=edit&redlink=1" class="new" title="7S seed storage protein (page does not exist)">7S seed storage protein</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Albumin" title="Albumin">Albumins</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Egg_white" title="Egg white">Egg white</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Conalbumin" class="mw-redirect" title="Conalbumin">Conalbumin</a></li> <li><a href="/wiki/Ovalbumin" title="Ovalbumin">Ovalbumin</a></li> <li><a href="/wiki/Avidin" title="Avidin">Avidin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Serum_albumin" title="Serum albumin">Serum albumin</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Human_serum_albumin" title="Human serum albumin">Human serum albumin</a></li> <li><a href="/wiki/Bovine_serum_albumin" title="Bovine serum albumin">Bovine serum albumin</a></li> <li><a href="/wiki/Transthyretin" title="Transthyretin">Prealbumin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C-reactive_protein" title="C-reactive protein">C-reactive protein</a></li> <li><a href="/wiki/Lactalbumin" title="Lactalbumin">Lactalbumin</a> (<a href="/wiki/Alpha-lactalbumin" class="mw-redirect" title="Alpha-lactalbumin">Alpha-lactalbumin</a>)</li> <li><a href="/wiki/Parvalbumin" title="Parvalbumin">Parvalbumin</a></li> <li><a href="/wiki/Ricin" title="Ricin">Ricin</a></li> <li><a href="/wiki/Vitamin_D-binding_protein" title="Vitamin D-binding protein">Vitamin D-binding protein</a></li> <li><a href="/wiki/Extracellular_matrix_protein_1" title="Extracellular matrix protein 1">Extracellular matrix protein 1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><div class="plainlist"> <ul><li><i>see also</i> <a href="/wiki/Template:Disorders_of_globin_and_globulin_proteins" title="Template:Disorders of globin and globulin proteins">disorders of globin and globulin proteins</a></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Androgen_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Androgen_receptor_modulators" title="Template:Androgen receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Androgen_receptor_modulators" title="Template talk:Androgen receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Androgen_receptor_modulators" title="Special:EditPage/Template:Androgen receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Androgen_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Androgen_receptor" title="Androgen receptor">Androgen receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Androgen_receptor" title="Androgen receptor"><abbr title="Androgen receptor">AR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Androgen receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Testosterone derivatives:</i> <a href="/wiki/4-Androstenediol" title="4-Androstenediol">4-Androstenediol</a></li> <li><a href="/wiki/4-Dehydroepiandrosterone" title="4-Dehydroepiandrosterone">4-Dehydroepiandrosterone (4-DHEA)</a></li> <li><a href="/wiki/4-Hydroxytestosterone" title="4-Hydroxytestosterone">4-Hydroxytestosterone</a></li> <li><a href="/w/index.php?title=4,17%CE%B1-Dimethyltestosterone&action=edit&redlink=1" class="new" title="4,17α-Dimethyltestosterone (page does not exist)">4,17α-Dimethyltestosterone</a></li> <li><a href="/wiki/5-Androstenedione" title="5-Androstenedione">5-Androstenedione</a></li> <li><a href="/wiki/11-Ketotestosterone" title="11-Ketotestosterone">11-Ketotestosterone</a></li> <li><a href="/wiki/11%CE%B2-Hydroxyandrostenedione" title="11β-Hydroxyandrostenedione">11β-Hydroxyandrostenedione</a></li> <li><a href="/wiki/Adrenosterone" title="Adrenosterone">Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione)</a></li> <li><a href="/wiki/5-Androstenediol" class="mw-redirect" title="5-Androstenediol">Androstenediol (5-androstenediol)</a> <ul><li><a href="/wiki/Androstenediol_3%CE%B2-acetate" title="Androstenediol 3β-acetate">Androstenediol 3β-acetate</a></li> <li><a href="/wiki/Androstenediol_17%CE%B2-acetate" title="Androstenediol 17β-acetate">Androstenediol 17β-acetate</a></li> <li><a href="/wiki/Androstenediol_diacetate" title="Androstenediol diacetate">Androstenediol diacetate</a></li> <li><a href="/wiki/Androstenediol_dipropionate" title="Androstenediol dipropionate">Androstenediol dipropionate</a></li></ul></li> <li><a href="/wiki/4-Androstenedione" class="mw-redirect" title="4-Androstenedione">Androstenedione (4-androstenedione)</a></li> <li><a href="/wiki/Atamestane" title="Atamestane">Atamestane</a></li> <li><a href="/wiki/Boldenone" title="Boldenone">Boldenone</a> <ul><li><a href="/wiki/Boldenone_undecylenate" title="Boldenone undecylenate">Boldenone undecylenate</a></li></ul></li> <li><a href="/wiki/Boldione" title="Boldione">Boldione (1,4-androstadienedione)</a></li> <li><a href="/wiki/Clostebol" title="Clostebol">Clostebol</a> <ul><li><a href="/wiki/Clostebol_acetate" title="Clostebol acetate">Clostebol acetate</a></li> <li><a href="/wiki/Clostebol_caproate" title="Clostebol caproate">Clostebol caproate</a></li> <li><a href="/wiki/Clostebol_propionate" title="Clostebol propionate">Clostebol propionate</a></li></ul></li> <li><a href="/wiki/Cloxotestosterone" title="Cloxotestosterone">Cloxotestosterone</a> <ul><li><a href="/wiki/Cloxotestosterone_acetate" title="Cloxotestosterone acetate">Cloxotestosterone acetate</a></li></ul></li> <li><a href="/wiki/Dehydroandrosterone" title="Dehydroandrosterone">Dehydroandrosterone</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA (androstenolone, prasterone; 5-DHEA)</a> <ul><li><a href="/wiki/Prasterone_enanthate" title="Prasterone enanthate">DHEA enanthate (prasterone enanthate)</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA sulfate</a></li></ul></li> <li><a href="/wiki/Exemestane" title="Exemestane">Exemestane</a></li> <li><a href="/wiki/Formestane" title="Formestane">Formestane</a></li> <li><a href="/wiki/Plomestane" title="Plomestane">Plomestane</a></li> <li><a href="/wiki/Quinbolone" title="Quinbolone">Quinbolone</a></li> <li><a href="/wiki/Silandrone" title="Silandrone">Silandrone</a></li> <li><a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">Testosterone</a><sup>#</sup> (<a href="/wiki/Testosterone/dutasteride" title="Testosterone/dutasteride">+dutasteride</a>) <ul><li><a href="/wiki/List_of_androgen_esters#Testosterone_esters" title="List of androgen esters">Testosterone esters</a></li> <li><a href="/wiki/Polytestosterone_phloretin_phosphate" title="Polytestosterone phloretin phosphate">Polytestosterone phloretin phosphate</a></li></ul></li></ul> <ul><li><i>5α-Dihydrotestosterone derivatives:</i> <a href="/wiki/1-Androstenediol" title="1-Androstenediol">1-Androstenediol</a></li> <li><a href="/wiki/1-Androstenedione" title="1-Androstenedione">1-Androstenedione</a></li> <li><a href="/wiki/1-Androsterone" title="1-Androsterone">1-Androsterone (1-andro, 1-DHEA)</a></li> <li><a href="/wiki/1-Testosterone" title="1-Testosterone">1-Testosterone</a></li> <li><a href="/wiki/3%CE%B1-Androstanediol" title="3α-Androstanediol">3α-Androstanediol</a></li> <li><a href="/wiki/5%CE%B1-Androst-2-en-17-one" class="mw-redirect" title="5α-Androst-2-en-17-one">5α-Androst-2-en-17-one</a></li> <li><a href="/wiki/7%CE%B2-Hydroxyepiandrosterone" title="7β-Hydroxyepiandrosterone">7β-Hydroxyepiandrosterone</a></li> <li><a href="/wiki/11-Ketodihydrotestosterone" title="11-Ketodihydrotestosterone">11-Ketodihydrotestosterone</a></li> <li><a href="/wiki/Androsterone" title="Androsterone">Androsterone</a></li> <li><a href="/wiki/Bolazine" title="Bolazine">Bolazine</a> <ul><li><a href="/wiki/Bolazine_capronate" title="Bolazine capronate">Bolazine capronate</a></li></ul></li> <li><a href="/w/index.php?title=Dihydroethyltestosterone&action=edit&redlink=1" class="new" title="Dihydroethyltestosterone (page does not exist)">Dihydroethyltestosterone</a></li> <li><a href="/wiki/Dihydrofluoxymesterone" title="Dihydrofluoxymesterone">Dihydrofluoxymesterone</a></li> <li><a href="/w/index.php?title=Dihydromethylandrostenediol&action=edit&redlink=1" class="new" title="Dihydromethylandrostenediol (page does not exist)">Dihydromethylandrostenediol</a></li> <li><a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">Dihydrotestosterone (DHT)</a> (<a href="/wiki/Androstanolone" title="Androstanolone">androstanolone, stanolone</a>) <ul><li><a href="/wiki/List_of_androgen_esters#Dihydrotestosterone_esters" title="List of androgen esters">Dihydrotestosterone esters</a></li></ul></li> <li><a href="/wiki/Drostanolone" title="Drostanolone">Drostanolone</a> <ul><li><a href="/wiki/Drostanolone_propionate" title="Drostanolone propionate">Drostanolone propionate</a></li></ul></li> <li><a href="/wiki/Epiandrosterone" title="Epiandrosterone">Epiandrosterone</a></li> <li><a href="/wiki/Epitiostanol" title="Epitiostanol">Epitiostanol</a></li> <li><a href="/wiki/Mepitiostane" title="Mepitiostane">Mepitiostane</a></li> <li><a href="/wiki/Mesabolone" title="Mesabolone">Mesabolone</a></li> <li><a href="/wiki/Mesterolone" title="Mesterolone">Mesterolone</a> <ul><li><a href="/wiki/Mesterolone_cipionate" title="Mesterolone cipionate">Mesterolone cipionate</a></li></ul></li> <li><a href="/wiki/Methyldiazinol" title="Methyldiazinol">Methyldiazinol</a></li> <li><a href="/wiki/Nisterime" title="Nisterime">Nisterime</a> <ul><li><a href="/wiki/Nisterime_acetate" title="Nisterime acetate">Nisterime acetate</a></li></ul></li> <li><a href="/wiki/Prostanozol" title="Prostanozol">Prostanozol</a></li> <li><a href="/wiki/Stenbolone" title="Stenbolone">Stenbolone</a> <ul><li><a href="/wiki/Stenbolone_acetate" title="Stenbolone acetate">Stenbolone acetate</a></li></ul></li> <li><a href="/wiki/Testifenon" title="Testifenon">Testifenon (testiphenon, testiphenone)</a></li></ul> <ul><li><i>19-Nortestosterone derivatives:</i> <a href="/wiki/7%CE%B1-Methyl-19-norandrostenedione" title="7α-Methyl-19-norandrostenedione">7α-Methyl-19-norandrostenedione (MENT dione, trestione)</a></li> <li><a href="/wiki/11%CE%B2-Methyl-19-nortestosterone" title="11β-Methyl-19-nortestosterone">11β-Methyl-19-nortestosterone</a> <ul><li><a href="/wiki/11%CE%B2-Methyl-19-nortestosterone_dodecylcarbonate" title="11β-Methyl-19-nortestosterone dodecylcarbonate">11β-Methyl-19-nortestosterone dodecylcarbonate</a></li></ul></li> <li><a href="/wiki/19-Nor-5-androstenediol" title="19-Nor-5-androstenediol">19-Nor-5-androstenediol</a></li> <li><a href="/wiki/19-Nor-5-androstenedione" title="19-Nor-5-androstenedione">19-Nor-5-androstenedione</a></li> <li><a href="/wiki/19-Nordehydroepiandrosterone" title="19-Nordehydroepiandrosterone">19-Nordehydroepiandrosterone</a></li> <li><a href="/wiki/Bolandiol" title="Bolandiol">Bolandiol</a> <ul><li><a href="/wiki/Bolandiol_dipropionate" title="Bolandiol dipropionate">Bolandiol dipropionate</a></li></ul></li> <li><a href="/wiki/Bolandione" title="Bolandione">Bolandione (19-nor-4-androstenedione)</a></li> <li><a href="/wiki/Bolmantalate" title="Bolmantalate">Bolmantalate (nandrolone adamantoate)</a></li> <li><a href="/wiki/Dienedione" title="Dienedione">Dienedione</a></li> <li><a href="/wiki/Dienolone" title="Dienolone">Dienolone</a></li> <li><a href="/wiki/Dimethandrolone" title="Dimethandrolone">Dimethandrolone</a> <ul><li><a href="/wiki/Dimethandrolone_buciclate" title="Dimethandrolone buciclate">Dimethandrolone buciclate</a></li> <li><a href="/wiki/Dimethandrolone_dodecylcarbonate" title="Dimethandrolone dodecylcarbonate">Dimethandrolone dodecylcarbonate</a></li> <li><a href="/wiki/Dimethandrolone_undecanoate" title="Dimethandrolone undecanoate">Dimethandrolone undecanoate</a></li></ul></li> <li><a href="/wiki/LS-1727" title="LS-1727">LS-1727 (nandrolone 17β-<i>N</i>-(2-chloroethyl)-<i>N</i>-nitrosocarbamate)</a></li> <li><a href="/wiki/Methoxydienone" title="Methoxydienone">Methoxydienone (methoxygonadiene)</a></li> <li><a href="/wiki/Nandrolone" title="Nandrolone">Nandrolone</a> <ul><li><a href="/wiki/List_of_androgen_esters#Nandrolone_esters" title="List of androgen esters">Nandrolone esters</a></li></ul></li> <li><a href="/wiki/Norclostebol" title="Norclostebol">Norclostebol</a> <ul><li><a href="/wiki/Norclostebol_acetate" title="Norclostebol acetate">Norclostebol acetate</a></li></ul></li> <li><a href="/wiki/Normethandrone" title="Normethandrone">Normethandrone (methylestrenolone, normethisterone)</a></li> <li><a href="/wiki/Oxabolone" title="Oxabolone">Oxabolone</a> <ul><li><a href="/wiki/Oxabolone_cipionate" title="Oxabolone cipionate">Oxabolone cipionate (oxabolone cypionate)</a></li></ul></li> <li><a href="/wiki/Trenbolone" title="Trenbolone">Trenbolone</a> <ul><li><a href="/wiki/Trenbolone_acetate" title="Trenbolone acetate">Trenbolone acetate</a></li> <li><a href="/wiki/Trenbolone_enanthate" title="Trenbolone enanthate">Trenbolone enanthate</a></li> <li><a href="/wiki/Trenbolone_hexahydrobenzylcarbonate" title="Trenbolone hexahydrobenzylcarbonate">Trenbolone hexahydrobenzylcarbonate</a></li> <li><a href="/wiki/Trenbolone_undecanoate" title="Trenbolone undecanoate">Trenbolone undecanoate</a></li></ul></li> <li><a href="/wiki/Trendione" title="Trendione">Trendione</a></li> <li><a href="/wiki/Trestolone" title="Trestolone">Trestolone (MENT)</a> <ul><li><a href="/wiki/Trestolone_acetate" title="Trestolone acetate">Trestolone acetate</a></li> <li><a href="/wiki/Trestolone_enanthate" title="Trestolone enanthate">Trestolone enanthate</a></li></ul></li></ul> <ul><li><i>5α-Dihydro-19-nortestosterone derivatives:</i> <a href="/wiki/5%CE%B1-Dihydronandrolone" title="5α-Dihydronandrolone">5α-Dihydronandrolone</a></li> <li><a href="/w/index.php?title=5%CE%B1-Dihydrotrestolone&action=edit&redlink=1" class="new" title="5α-Dihydrotrestolone (page does not exist)">5α-Dihydrotrestolone</a></li> <li><a href="/wiki/19-Norandrosterone" title="19-Norandrosterone">19-Norandrosterone</a></li></ul> <ul><li><i>17α-Alkylated testosterone derivatives:</i> <a href="/wiki/Bolasterone" title="Bolasterone">Bolasterone</a></li> <li><a href="/wiki/Calusterone" title="Calusterone">Calusterone</a></li> <li><a href="/wiki/Chlorodehydromethylandrostenediol" title="Chlorodehydromethylandrostenediol">Chlorodehydromethylandrostenediol (CDMA)</a></li> <li><a href="/wiki/Chlorodehydromethyltestosterone" title="Chlorodehydromethyltestosterone">Chlorodehydromethyltestosterone (CDMT)</a></li> <li><a href="/wiki/Chloromethylandrostenediol" title="Chloromethylandrostenediol">Chloromethylandrostenediol (CMA)</a></li> <li><a href="/wiki/Enestebol" title="Enestebol">Enestebol</a></li> <li><a href="/wiki/Ethyltestosterone" title="Ethyltestosterone">Ethyltestosterone</a></li> <li><a href="/wiki/Fluoxymesterone" title="Fluoxymesterone">Fluoxymesterone</a></li> <li><a href="/wiki/Formebolone" title="Formebolone">Formebolone</a></li> <li><a href="/wiki/Hydroxystenozole" title="Hydroxystenozole">Hydroxystenozole</a></li> <li><a href="/wiki/Metandienone" title="Metandienone">Metandienone (methandrostenolone)</a></li> <li><a href="/wiki/Methandriol" title="Methandriol">Methandriol (methylandrostenediol)</a> <ul><li><a href="/wiki/Methandriol_bisenanthoyl_acetate" title="Methandriol bisenanthoyl acetate">Methandriol bisenanthoyl acetate</a></li> <li><a href="/wiki/Methandriol_diacetate" title="Methandriol diacetate">Methandriol diacetate</a></li> <li><a href="/wiki/Methandriol_dipropionate" title="Methandriol dipropionate">Methandriol dipropionate</a></li> <li><a href="/wiki/Methandriol_propionate" title="Methandriol propionate">Methandriol propionate</a></li></ul></li> <li><a href="/wiki/Methylclostebol" title="Methylclostebol">Methylclostebol (chloromethyltestosterone)</a></li> <li><a href="/wiki/Methyltestosterone" title="Methyltestosterone">Methyltestosterone</a> (<a href="/wiki/Esterified_estrogens/methyltestosterone" title="Esterified estrogens/methyltestosterone">+esterified estrogens</a>) <ul><li><a href="/wiki/Methyltestosterone_3-hexyl_ether" title="Methyltestosterone 3-hexyl ether">Methyltestosterone 3-hexyl ether</a></li></ul></li> <li><a href="/wiki/Oxymesterone" title="Oxymesterone">Oxymesterone</a></li> <li><a href="/wiki/Penmesterol" title="Penmesterol">Penmesterol</a></li> <li><a href="/wiki/Tiomesterone" title="Tiomesterone">Tiomesterone</a></li></ul> <ul><li><i>17α-Alkylated 5α-dihydrotestosterone derivatives:</i> <a href="/wiki/Androisoxazole" title="Androisoxazole">Androisoxazole</a></li> <li><a href="/wiki/Desoxymethyltestosterone" title="Desoxymethyltestosterone">Desoxymethyltestosterone</a></li> <li><a href="/wiki/Furazabol" title="Furazabol">Furazabol</a></li> <li><a href="/wiki/Mebolazine" title="Mebolazine">Mebolazine (dimethazine)</a></li> <li><a href="/wiki/Mestanolone" title="Mestanolone">Mestanolone</a></li> <li><a href="/wiki/Metenolone" title="Metenolone">Metenolone</a> <ul><li><a href="/wiki/Metenolone_acetate" title="Metenolone acetate">Metenolone acetate</a></li> <li><a href="/wiki/Metenolone_enanthate" title="Metenolone enanthate">Metenolone enanthate</a></li></ul></li> <li><a href="/wiki/Methasterone" title="Methasterone">Methasterone</a></li> <li><a href="/wiki/Methyl-1-testosterone" title="Methyl-1-testosterone">Methyl-1-testosterone</a></li> <li><a href="/wiki/Methylepitiostanol" title="Methylepitiostanol">Methylepitiostanol</a></li> <li><a href="/wiki/Methylstenbolone" title="Methylstenbolone">Methylstenbolone</a></li> <li><a href="/wiki/Oxandrolone" title="Oxandrolone">Oxandrolone</a></li> <li><a href="/wiki/Oxymetholone" title="Oxymetholone">Oxymetholone</a></li> <li><a href="/wiki/Stanozolol" title="Stanozolol">Stanozolol</a></li></ul> <ul><li><i>17α-Alkylated 19-nortestosterone derivatives:</i> <a href="/wiki/Bolenol" title="Bolenol">Bolenol</a></li> <li><a href="/wiki/Dimethyldienolone" title="Dimethyldienolone">Dimethyldienolone</a></li> <li><a href="/wiki/Dimethyltrienolone" title="Dimethyltrienolone">Dimethyltrienolone</a></li> <li><a href="/wiki/Ethyldienolone" title="Ethyldienolone">Ethyldienolone</a></li> <li><a href="/wiki/Ethylestrenol" title="Ethylestrenol">Ethylestrenol</a></li> <li><a href="/wiki/Methyldienolone" title="Methyldienolone">Methyldienolone</a></li> <li><a href="/wiki/Methylhydroxynandrolone" title="Methylhydroxynandrolone">Methylhydroxynandrolone (MOHN, MHN)</a></li> <li><a href="/wiki/Metribolone" title="Metribolone">Metribolone</a></li> <li><a href="/wiki/Mibolerone" title="Mibolerone">Mibolerone</a></li> <li><a href="/wiki/Norboletone" title="Norboletone">Norboletone</a></li> <li><a href="/wiki/Norethandrolone" title="Norethandrolone">Norethandrolone</a></li> <li><a href="/wiki/Propetandrol" title="Propetandrol">Propetandrol</a></li> <li><a href="/wiki/RU-2309" title="RU-2309">RU-2309</a></li> <li><a href="/wiki/Tetrahydrogestrinone" title="Tetrahydrogestrinone">Tetrahydrogestrinone</a></li></ul> <ul><li><i>17α-Alkylated 5α-dihydro-19-nortestosterone derivatives:</i> <a href="/wiki/5%CE%B1-Dihydronorethandrolone" title="5α-Dihydronorethandrolone">5α-Dihydronorethandrolone</a></li> <li><a href="/wiki/5%CE%B1-Dihydronormethandrone" title="5α-Dihydronormethandrone">5α-Dihydronormethandrone</a></li></ul> <ul><li><i>17α-Vinyltestosterone derivatives:</i> <a href="/wiki/Norvinisterone" title="Norvinisterone">Norvinisterone (vinylnortestosterone)</a></li></ul> <ul><li><i>17α-Vinyl-19-nortestosterone derivatives:</i> <a href="/wiki/Vinyltestosterone" title="Vinyltestosterone">Vinyltestosterone</a></li></ul> <ul><li><i>17α-Ethynyltestosterone derivatives:</i> <a href="/wiki/Danazol" title="Danazol">Danazol</a></li> <li><a href="/wiki/Ethinylandrostenediol" title="Ethinylandrostenediol">Ethinylandrostenediol</a> <ul><li><a href="/wiki/Ethandrostate" title="Ethandrostate">Ethandrostate</a></li></ul></li> <li><a href="/wiki/Ethisterone" title="Ethisterone">Ethisterone (ethynyltestosterone)</a></li></ul> <ul><li><i>5α-Dihydro-17α-ethynyltestosterone derivatives:</i> <a href="/wiki/17%CE%B1-Ethynyl-3%CE%B1-androstanediol" title="17α-Ethynyl-3α-androstanediol">17α-Ethynyl-3α-androstanediol</a></li> <li><a href="/wiki/17%CE%B1-Ethynyl-3%CE%B2-androstanediol" title="17α-Ethynyl-3β-androstanediol">17α-Ethynyl-3β-androstanediol</a></li> <li><a href="/wiki/Dihydroethisterone" class="mw-redirect" title="Dihydroethisterone">Dihydroethisterone</a></li></ul> <ul><li><i>17α-Ethynyl-19-nortestosterone derivatives:</i> <a href="/wiki/%CE%944-Tibolone" title="Δ4-Tibolone">Δ<sup>4</sup>-Tibolone</a></li> <li><a href="/wiki/Desogestrel" title="Desogestrel">Desogestrel</a></li> <li><a href="/wiki/Etonogestrel" title="Etonogestrel">Etonogestrel</a></li> <li><a href="/wiki/Etynodiol" title="Etynodiol">Etynodiol</a> <ul><li><a href="/wiki/Etynodiol_diacetate" title="Etynodiol diacetate">Etynodiol diacetate</a></li></ul></li> <li><a href="/wiki/Gestodene" title="Gestodene">Gestodene</a></li> <li><a href="/wiki/Gestrinone" title="Gestrinone">Gestrinone</a></li> <li><a href="/wiki/Levonorgestrel" title="Levonorgestrel">Levonorgestrel</a></li> <li><a href="/wiki/Levonorgestrel_ester" class="mw-redirect" title="Levonorgestrel ester">Levonorgestrel esters</a> (e.g., <a href="/wiki/Levonorgestrel_butanoate" title="Levonorgestrel butanoate">levonorgestrel butanoate</a>)</li> <li><a href="/wiki/Lynestrenol" title="Lynestrenol">Lynestrenol</a> <ul><li><a href="/wiki/Lynestrenol_phenylpropionate" title="Lynestrenol phenylpropionate">Lynestrenol phenylpropionate</a></li></ul></li> <li><a href="/wiki/Norethisterone" title="Norethisterone">Norethisterone</a></li> <li><a href="/wiki/Norethisterone_ester" class="mw-redirect" title="Norethisterone ester">Norethisterone esters</a> (e.g., <a href="/wiki/Norethisterone_acetate" title="Norethisterone acetate">norethisterone acetate</a>, <a href="/wiki/Norethisterone_enanthate" title="Norethisterone enanthate">norethisterone enanthate</a>)</li> <li><a href="/wiki/Norgestrel" title="Norgestrel">Norgestrel</a></li> <li><a href="/wiki/Norgestrienone" title="Norgestrienone">Norgestrienone</a></li> <li><a href="/wiki/Quingestanol" title="Quingestanol">Quingestanol</a> <ul><li><a href="/wiki/Quingestanol_acetate" title="Quingestanol acetate">Quingestanol acetate</a></li></ul></li> <li><a href="/wiki/Tibolone" title="Tibolone">Tibolone</a></li></ul> <ul><li><i>5α-Dihydro-17α-ethynyl-19-nortestosterone derivatives:</i> <a href="/wiki/5%CE%B1-Dihydrolevonorgestrel" title="5α-Dihydrolevonorgestrel">5α-Dihydrolevonorgestrel</a></li> <li><a href="/wiki/5%CE%B1-Dihydronorethisterone" title="5α-Dihydronorethisterone">5α-Dihydronorethisterone</a></li></ul> <ul><li><i>Progesterone derivatives:</i> <a href="/wiki/6%CE%B1-Methylprogesterone" title="6α-Methylprogesterone">6α-Methylprogesterone</a></li> <li><a href="/wiki/Medroxyprogesterone_acetate" title="Medroxyprogesterone acetate">Medroxyprogesterone acetate</a></li> <li><a href="/wiki/Megestrol_acetate" title="Megestrol acetate">Megestrol acetate</a></li></ul> <ul><li><i>Others/unsorted:</i> <a href="/wiki/3-Keto-5%CE%B1-abiraterone" title="3-Keto-5α-abiraterone">3-Keto-5α-abiraterone</a></li> <li><a href="/wiki/5%CE%B1-Androstane" class="mw-redirect" title="5α-Androstane">5α-Androstane</a></li> <li><a href="/wiki/Alternariol" title="Alternariol">Alternariol</a></li> <li><a href="/wiki/Cl-4AS-1" title="Cl-4AS-1">Cl-4AS-1</a></li> <li><a href="/wiki/Drupanol" title="Drupanol">Drupanol</a></li> <li><a href="/wiki/Trilostane" title="Trilostane">Trilostane</a></li> <li><a href="/wiki/ZM-182345" title="ZM-182345">ZM-182345</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center"><a href="/wiki/Selective_androgen_receptor_modulator" title="Selective androgen receptor modulator"><abbr title="Selective androgen receptor modulator">SARMs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Selective androgen receptor modulator</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Nonsteroidal:</i> <a href="/w/index.php?title=198RL26&action=edit&redlink=1" class="new" title="198RL26 (page does not exist)">198RL26</a></li> <li><a href="/wiki/ACP-105" title="ACP-105">ACP-105</a></li> <li><a href="/wiki/AC-262,536" title="AC-262,536">AC-262,536</a></li> <li><a href="/wiki/Acetothiolutamide" title="Acetothiolutamide">Acetothiolutamide</a></li> <li><a href="/wiki/Acetoxolutamide" title="Acetoxolutamide">Acetoxolutamide</a></li> <li><a href="/wiki/Andarine" title="Andarine">Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4)</a></li> <li><a href="/wiki/BMS-564,929" title="BMS-564,929">BMS-564,929</a></li> <li><a href="/w/index.php?title=DTIB&action=edit&redlink=1" class="new" title="DTIB (page does not exist)">DTIB</a></li> <li><a href="/wiki/Enobosarm" title="Enobosarm">Enobosarm (ostarine, MK-2866, GTx-024, S-22)</a></li> <li><a href="/w/index.php?title=FTBU-1&action=edit&redlink=1" class="new" title="FTBU-1 (page does not exist)">FTBU-1</a></li> <li><a href="/wiki/GLPG-0492" title="GLPG-0492">GLPG-0492</a></li> <li><a href="/wiki/GSK2881078" title="GSK2881078">GSK2881078</a></li> <li><a href="/wiki/GSK-4336A" title="GSK-4336A">GSK-4336A</a></li> <li><a href="/w/index.php?title=GSK-8698&action=edit&redlink=1" class="new" title="GSK-8698 (page does not exist)">GSK-8698</a></li> <li><a href="/wiki/LG121071" title="LG121071">LG121071 (LGD-121071)</a></li> <li><a href="/wiki/LGD-2226" title="LGD-2226">LGD-2226</a></li> <li><a href="/wiki/LGD-2941" title="LGD-2941">LGD-2941 (LGD-122941)</a></li> <li><a href="/wiki/LGD-3303" title="LGD-3303">LGD-3303</a></li> <li><a href="/wiki/LGD-4033" class="mw-redirect" title="LGD-4033">LGD-4033</a></li> <li><a href="/wiki/LY305" title="LY305">LY305</a></li> <li><a href="/wiki/JNJ-26146900" title="JNJ-26146900">JNJ-26146900</a></li> <li><a href="/wiki/JNJ-28330835" title="JNJ-28330835">JNJ-28330835</a></li> <li><a href="/wiki/JNJ-37654032" title="JNJ-37654032">JNJ-37654032</a></li> <li><a href="/wiki/OPK-88004" title="OPK-88004">OPK-88004 (LY-2452473, TT-701)</a></li> <li><a href="/w/index.php?title=ORM-11984&action=edit&redlink=1" class="new" title="ORM-11984 (page does not exist)">ORM-11984</a></li> <li><a href="/wiki/PF-06260414" title="PF-06260414">PF-06260414</a></li> <li><a href="/w/index.php?title=R-1_(drug)&action=edit&redlink=1" class="new" title="R-1 (drug) (page does not exist)">R-1</a></li> <li><a href="/wiki/RU-59063" title="RU-59063">RU-59063</a></li> <li><a href="/w/index.php?title=S-1_(drug)&action=edit&redlink=1" class="new" title="S-1 (drug) (page does not exist)">S-1</a></li> <li><a href="/wiki/S-23_(drug)" title="S-23 (drug)">S-23</a></li> <li><a href="/wiki/S-40503" title="S-40503">S-40503</a></li> <li><a href="/w/index.php?title=S-101479&action=edit&redlink=1" class="new" title="S-101479 (page does not exist)">S-101479</a></li> <li><a href="/wiki/Vosilasarm" title="Vosilasarm">Vosilasarm</a></li></ul> <ul><li><i>Steroidal:</i> <a href="/w/index.php?title=EM-9017&action=edit&redlink=1" class="new" title="EM-9017 (page does not exist)">EM-9017</a></li> <li><a href="/wiki/MK-0773" title="MK-0773">MK-0773</a></li> <li><a href="/wiki/TFM-4AS-1" title="TFM-4AS-1">TFM-4AS-1</a></li> <li><a href="/wiki/YK-11" title="YK-11">YK-11</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Steroidal:</i> <a href="/wiki/7%CE%B1-Thioprogesterone" title="7α-Thioprogesterone">7α-Thioprogesterone</a></li> <li><a href="/wiki/7%CE%B1-Thiospironolactone" title="7α-Thiospironolactone">7α-Thiospironolactone</a></li> <li><a href="/wiki/7%CE%B1-Thiomethylspironolactone" title="7α-Thiomethylspironolactone">7α-Thiomethylspironolactone</a></li> <li><a href="/wiki/11%CE%B1-Hydroxyprogesterone" title="11α-Hydroxyprogesterone">11α-Hydroxyprogesterone</a></li> <li><a href="/wiki/15%CE%B2-Hydroxycyproterone_acetate" title="15β-Hydroxycyproterone acetate">15β-Hydroxycyproterone acetate</a></li> <li><a href="/wiki/Abiraterone" class="mw-redirect" title="Abiraterone">Abiraterone</a></li> <li><a href="/wiki/Abiraterone_acetate" title="Abiraterone acetate">Abiraterone acetate</a></li> <li><a href="/wiki/Allyltestosterone" title="Allyltestosterone">Allyltestosterone</a></li> <li><a href="/wiki/Benorterone" title="Benorterone">Benorterone</a></li> <li><a href="/wiki/BOMT" title="BOMT">BOMT</a></li> <li><a href="/wiki/Canrenoic_acid" title="Canrenoic acid">Canrenoic acid</a></li> <li><a href="/wiki/Canrenone" title="Canrenone">Canrenone</a></li> <li><a href="/wiki/Chlormadinone_acetate" title="Chlormadinone acetate">Chlormadinone acetate</a></li> <li><a href="/wiki/Clascoterone" title="Clascoterone">Clascoterone</a></li> <li><a href="/wiki/Clometerone" title="Clometerone">Clometerone</a></li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/Cyproterone" title="Cyproterone">Cyproterone</a></li> <li><a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">Cyproterone acetate</a></li> <li><a href="/wiki/Delanterone" title="Delanterone">Delanterone</a></li> <li><a href="/wiki/Delmadinone_acetate" title="Delmadinone acetate">Delmadinone acetate</a></li> <li><a href="/wiki/Dicirenone" title="Dicirenone">Dicirenone</a></li> <li><a href="/wiki/Dienogest" title="Dienogest">Dienogest</a></li> <li><a href="/wiki/Drospirenone" title="Drospirenone">Drospirenone</a></li> <li><a href="/wiki/DU-41165" title="DU-41165">DU-41165</a></li> <li><a href="/wiki/Edogestrone" title="Edogestrone">Edogestrone</a></li> <li><a href="/w/index.php?title=EM-4350&action=edit&redlink=1" class="new" title="EM-4350 (page does not exist)">EM-4350</a></li> <li><a href="/wiki/EM-5854" title="EM-5854">EM-5854</a></li> <li><a href="/w/index.php?title=EM-5855&action=edit&redlink=1" class="new" title="EM-5855 (page does not exist)">EM-5855</a></li> <li><a href="/w/index.php?title=EM-6537&action=edit&redlink=1" class="new" title="EM-6537 (page does not exist)">EM-6537</a></li> <li><a href="/wiki/Epitestosterone" title="Epitestosterone">Epitestosterone</a></li> <li><a href="/wiki/Galeterone" title="Galeterone">Galeterone</a></li> <li><a href="/wiki/Guggulsterone" title="Guggulsterone">Guggulsterone</a></li> <li><a href="/w/index.php?title=Ludaterone&action=edit&redlink=1" class="new" title="Ludaterone (page does not exist)">Ludaterone</a></li> <li><a href="/wiki/Medrogestone" title="Medrogestone">Medrogestone</a></li> <li><a href="/wiki/Megestrol_acetate" title="Megestrol acetate">Megestrol acetate</a></li> <li><a href="/wiki/Mespirenone" title="Mespirenone">Mespirenone</a></li> <li><a href="/wiki/Metogest" title="Metogest">Metogest</a></li> <li><a href="/wiki/Mexrenone" title="Mexrenone">Mexrenone</a></li> <li><a href="/wiki/Mifepristone" title="Mifepristone">Mifepristone</a></li> <li><a href="/wiki/Nomegestrol_acetate" title="Nomegestrol acetate">Nomegestrol acetate</a></li> <li><a href="/wiki/Nordinone" title="Nordinone">Nordinone</a></li> <li><a href="/wiki/Osaterone" title="Osaterone">Osaterone</a></li> <li><a href="/wiki/Osaterone_acetate" title="Osaterone acetate">Osaterone acetate</a></li> <li><a href="/wiki/Oxendolone" title="Oxendolone">Oxendolone</a></li> <li><a href="/wiki/Potassium_canrenoate" title="Potassium canrenoate">Potassium canrenoate</a></li> <li><a href="/wiki/Promegestone" title="Promegestone">Promegestone</a></li> <li><a href="/wiki/Prorenone" title="Prorenone">Prorenone</a></li> <li><a href="/wiki/Rosterolone" title="Rosterolone">Rosterolone</a></li> <li><a href="/w/index.php?title=RU-15328&action=edit&redlink=1" class="new" title="RU-15328 (page does not exist)">RU-15328</a></li> <li><a href="/wiki/SC-5233" title="SC-5233">SC-5233 (spirolactone)</a></li> <li><a href="/wiki/Spironolactone" title="Spironolactone">Spironolactone</a></li> <li><a href="/wiki/Spirorenone" title="Spirorenone">Spirorenone</a></li> <li><a href="/wiki/Spiroxasone" title="Spiroxasone">Spiroxasone</a></li> <li><a href="/wiki/Topterone" title="Topterone">Topterone</a></li> <li><a href="/wiki/Trimegestone" title="Trimegestone">Trimegestone</a></li> <li><a href="/wiki/Trimethyltrienolone" title="Trimethyltrienolone">Trimethyltrienolone (R-2956)</a></li> <li><a href="/wiki/Zanoterone" title="Zanoterone">Zanoterone</a></li></ul> <ul><li><i>Nonsteroidal:</i> <a href="/wiki/5N-Bicalutamide" title="5N-Bicalutamide">5<i>N</i>-Bicalutamide</a></li> <li><a href="/wiki/AA560" title="AA560">AA560</a></li> <li><a href="/w/index.php?title=Antarlide&action=edit&redlink=1" class="new" title="Antarlide (page does not exist)">Antarlides</a></li> <li><a href="/w/index.php?title=Arabilin&action=edit&redlink=1" class="new" title="Arabilin (page does not exist)">Arabilin</a></li> <li><a href="/wiki/Apalutamide" title="Apalutamide">Apalutamide</a></li> <li><a href="/wiki/Atraric_acid" title="Atraric acid">Atraric acid</a></li> <li><a href="/w/index.php?title=AZD-3514&action=edit&redlink=1" class="new" title="AZD-3514 (page does not exist)">AZD-3514</a></li> <li><a href="/wiki/Bakuchiol" title="Bakuchiol">Bakuchiol</a></li> <li><a href="/wiki/Bavdegalutamide" title="Bavdegalutamide">Bavdegalutamide</a></li> <li><a href="/w/index.php?title=BAY-1024767&action=edit&redlink=1" class="new" title="BAY-1024767 (page does not exist)">BAY-1024767</a></li> <li><a href="/wiki/Bicalutamide" title="Bicalutamide">Bicalutamide</a></li> <li><a href="/wiki/Bisphenol" title="Bisphenol">Bisphenols</a> (e.g., <a href="/wiki/Bisphenol_A_diglycidyl_ether" title="Bisphenol A diglycidyl ether">BADGE</a>, <a href="/w/index.php?title=Bisphenol_F_diglycidyl_ether&action=edit&redlink=1" class="new" title="Bisphenol F diglycidyl ether (page does not exist)">BFDGE</a>, <a href="/wiki/Bisphenol_A" title="Bisphenol A">bisphenol A</a>, <a href="/wiki/Bisphenol_F" title="Bisphenol F">bisphenol F</a>, <a href="/wiki/Bisphenol_S" title="Bisphenol S">bisphenol S</a>)</li> <li><a href="/w/index.php?title=BMS-501949&action=edit&redlink=1" class="new" title="BMS-501949 (page does not exist)">BMS-501949</a></li> <li><a href="/w/index.php?title=BMS-570511&action=edit&redlink=1" class="new" title="BMS-570511 (page does not exist)">BMS-570511</a></li> <li><a href="/wiki/BMS-641988" title="BMS-641988">BMS-641988</a></li> <li><a href="/w/index.php?title=CH5137291&action=edit&redlink=1" class="new" title="CH5137291 (page does not exist)">CH5137291</a></li> <li><a href="/wiki/Cimetidine" title="Cimetidine">Cimetidine</a></li> <li><a href="/wiki/Cioteronel" title="Cioteronel">Cioteronel</a></li> <li><a href="/wiki/Cyanonilutamide" title="Cyanonilutamide">Cyanonilutamide</a></li> <li><a href="/wiki/Darolutamide" title="Darolutamide">Darolutamide</a></li> <li><a href="/wiki/DDT" title="DDT">DDT</a> (via metabolite <a href="/wiki/Dichlorodiphenyldichloroethylene" title="Dichlorodiphenyldichloroethylene">p,p’-DDE</a>)</li> <li><a href="/wiki/Dieldrin" title="Dieldrin">Dieldrin</a></li> <li><a href="/wiki/DIMP_(antiandrogen)" title="DIMP (antiandrogen)">DIMP</a></li> <li><a href="/wiki/Endosulfan" title="Endosulfan">Endosulfan</a></li> <li><a href="/wiki/Enzalutamide" title="Enzalutamide">Enzalutamide</a></li> <li><a href="/wiki/EPI-001" title="EPI-001">EPI-001</a></li> <li><a href="/wiki/Fenarimol" title="Fenarimol">Fenarimol</a></li> <li><a href="/wiki/Flutamide" title="Flutamide">Flutamide</a></li> <li><a href="/wiki/Hydroxyflutamide" title="Hydroxyflutamide">Hydroxyflutamide</a></li> <li><a href="/wiki/Inocoterone" title="Inocoterone">Inocoterone</a></li> <li><a href="/wiki/Inocoterone_acetate" title="Inocoterone acetate">Inocoterone acetate</a></li> <li><a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a></li> <li><a href="/wiki/Ketodarolutamide" title="Ketodarolutamide">Ketodarolutamide</a></li> <li><a href="/wiki/Lavender_oil" title="Lavender oil">Lavender oil</a></li> <li><a href="/w/index.php?title=LG-105&action=edit&redlink=1" class="new" title="LG-105 (page does not exist)">LG-105</a></li> <li><a href="/wiki/LG-120907" title="LG-120907">LG-120907</a></li> <li><a href="/w/index.php?title=LGD-1331&action=edit&redlink=1" class="new" title="LGD-1331 (page does not exist)">LGD-1331</a></li> <li><a href="/wiki/Linuron" title="Linuron">Linuron</a></li> <li><a href="/wiki/Masofaniten" title="Masofaniten">Masofaniten</a></li> <li><a href="/wiki/Methiocarb" title="Methiocarb">Methiocarb</a></li> <li><a href="/w/index.php?title=N-Butylbenzenesulfonamide&action=edit&redlink=1" class="new" title="N-Butylbenzenesulfonamide (page does not exist)"><i>N</i>-Butylbenzenesulfonamide</a></li> <li><a href="/wiki/N-Desmethylapalutamide" title="N-Desmethylapalutamide"><i>N</i>-Desmethylapalutamide</a></li> <li><a href="/wiki/N-Desmethylenzalutamide" title="N-Desmethylenzalutamide"><i>N</i>-Desmethylenzalutamide</a></li> <li><a href="/wiki/Nilutamide" title="Nilutamide">Nilutamide</a></li> <li><a href="/w/index.php?title=ONC1-13B&action=edit&redlink=1" class="new" title="ONC1-13B (page does not exist)">ONC1-13B</a></li> <li><a href="/wiki/Pentomone" title="Pentomone">Pentomone</a></li> <li><a href="/w/index.php?title=PF-998425&action=edit&redlink=1" class="new" title="PF-998425 (page does not exist)">PF-998425</a></li> <li><a href="/wiki/Phenothrin" title="Phenothrin">Phenothrin</a></li> <li><a href="/wiki/Prochloraz" title="Prochloraz">Prochloraz</a></li> <li><a href="/wiki/Procymidone" title="Procymidone">Procymidone</a></li> <li><a href="/wiki/Proxalutamide" title="Proxalutamide">Proxalutamide</a></li> <li><a href="/wiki/Pyrilutamide" title="Pyrilutamide">Pyrilutamide</a></li> <li><a href="/wiki/Ralaniten" title="Ralaniten">Ralaniten (EPI-002)</a></li> <li><a href="/wiki/Ralaniten_acetate" title="Ralaniten acetate">Ralaniten acetate (EPI-506)</a></li> <li><a href="/wiki/RD-162" title="RD-162">RD-162</a></li> <li><a href="/wiki/Rezvilutamide" title="Rezvilutamide">Rezvilutamide</a></li> <li><a href="/w/index.php?title=Ro_2-7239&action=edit&redlink=1" class="new" title="Ro 2-7239 (page does not exist)">Ro 2-7239</a></li> <li><a href="/w/index.php?title=Ro_5-2537&action=edit&redlink=1" class="new" title="Ro 5-2537 (page does not exist)">Ro 5-2537</a></li> <li><a href="/wiki/RU-22930" title="RU-22930">RU-22930</a></li> <li><a href="/wiki/RU-56187" title="RU-56187">RU-56187</a></li> <li><a href="/wiki/RU-57073" title="RU-57073">RU-57073</a></li> <li><a href="/wiki/RU-58642" title="RU-58642">RU-58642</a></li> <li><a href="/wiki/RU-58841" title="RU-58841">RU-58841</a></li> <li><a href="/wiki/Seviteronel" title="Seviteronel">Seviteronel</a></li> <li><a href="/wiki/Thalidomide" title="Thalidomide">Thalidomide</a></li> <li><a href="/wiki/Topilutamide" title="Topilutamide">Topilutamide (fluridil)</a></li> <li><a href="/wiki/Valproic_acid" class="mw-redirect" title="Valproic acid">Valproic acid</a></li> <li><a href="/wiki/Vinclozolin" title="Vinclozolin">Vinclozolin</a></li> <li><a href="/w/index.php?title=YM-580&action=edit&redlink=1" class="new" title="YM-580 (page does not exist)">YM-580</a></li> <li><a href="/w/index.php?title=YM-92088&action=edit&redlink=1" class="new" title="YM-92088 (page does not exist)">YM-92088</a></li> <li><a href="/w/index.php?title=YM-175735&action=edit&redlink=1" class="new" title="YM-175735 (page does not exist)">YM-175735</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GPRC6A" title="GPRC6A">GPRC6A</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cation" class="mw-redirect" title="Cation">Cations</a> (incl. <a href="/wiki/Aluminium" title="Aluminium">aluminium</a>, <a href="/wiki/Calcium" title="Calcium">calcium</a>, <a href="/wiki/Gadolinium" title="Gadolinium">gadolinium</a>, <a href="/wiki/Magnesium" title="Magnesium">magnesium</a>, <a href="/wiki/Strontium" title="Strontium">strontium</a>, <a href="/wiki/Zinc" title="Zinc">zinc</a>)</li> <li><a href="/wiki/Dehydroandrosterone" title="Dehydroandrosterone">Dehydroandrosterone</a></li> <li><a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">Dihydrotestosterone</a></li> <li><a href="/wiki/Estradiol" title="Estradiol">Estradiol</a></li> <li><a href="/wiki/Amino_acid" title="Amino acid"><small>L</small>-α-Amino acids</a> (incl. <a href="/wiki/Arginine" title="Arginine"><small>L</small>-arginine</a>, <a href="/wiki/Lysine" title="Lysine"><small>L</small>-lysine</a>, <a href="/wiki/Ornithine" title="Ornithine"><small>L</small>-ornithine</a>)</li> <li><a href="/wiki/Osteocalcin" title="Osteocalcin">Osteocalcin</a></li> <li><a class="mw-selflink selflink"><abbr title="Sex hormone-binding globulin">SHBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Sex hormone-binding globulin</span></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></dd> <dd><a href="/wiki/Template:Androgens_and_antiandrogens" title="Template:Androgens and antiandrogens">Androgens and antiandrogens</a></dd> <dd><a href="/wiki/Template:Estrogen_receptor_modulators" title="Template:Estrogen receptor modulators">Estrogen receptor modulators</a></dd> <dd><a href="/wiki/Template:Progesterone_receptor_modulators" title="Template:Progesterone receptor modulators">Progesterone receptor modulators</a></dd> <dd><a href="/wiki/List_of_androgens_and_anabolic_steroids" title="List of androgens and anabolic steroids">List of androgens and anabolic steroids</a></dd></dl> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Estrogen_receptor_modulators" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Estrogen_receptor_modulators" title="Template:Estrogen receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Estrogen_receptor_modulators" title="Template talk:Estrogen receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Estrogen_receptor_modulators" title="Special:EditPage/Template:Estrogen receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Estrogen_receptor_modulators" style="font-size:114%;margin:0 4em"><a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Estrogen_receptor" title="Estrogen receptor"><abbr title="Estrogen receptor">ER</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Estrogen receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Steroidal:</i> <a href="/wiki/2-Hydroxyestradiol" title="2-Hydroxyestradiol">2-Hydroxyestradiol</a></li> <li><a href="/wiki/2-Hydroxyestrone" title="2-Hydroxyestrone">2-Hydroxyestrone</a></li> <li><a href="/wiki/3-Methyl-19-methyleneandrosta-3,5-dien-17%CE%B2-ol" title="3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol">3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol</a></li> <li><a href="/wiki/3%CE%B1-Androstanediol" title="3α-Androstanediol">3α-Androstanediol</a></li> <li><a href="/w/index.php?title=3%CE%B1,5%CE%B1-Dihydrolevonorgestrel&action=edit&redlink=1" class="new" title="3α,5α-Dihydrolevonorgestrel (page does not exist)">3α,5α-Dihydrolevonorgestrel</a></li> <li><a href="/w/index.php?title=3%CE%B2,5%CE%B1-Dihydrolevonorgestrel&action=edit&redlink=1" class="new" title="3β,5α-Dihydrolevonorgestrel (page does not exist)">3β,5α-Dihydrolevonorgestrel</a></li> <li><a href="/wiki/3%CE%B1-Hydroxytibolone" title="3α-Hydroxytibolone">3α-Hydroxytibolone</a></li> <li><a href="/wiki/3%CE%B2-Hydroxytibolone" title="3β-Hydroxytibolone">3β-Hydroxytibolone</a></li> <li><a href="/wiki/3%CE%B2-Androstanediol" title="3β-Androstanediol">3β-Androstanediol</a></li> <li><a href="/wiki/4-Androstenediol" title="4-Androstenediol">4-Androstenediol</a></li> <li><a href="/wiki/4-Androstenedione" class="mw-redirect" title="4-Androstenedione">4-Androstenedione</a></li> <li><a href="/wiki/4-Fluoroestradiol" title="4-Fluoroestradiol">4-Fluoroestradiol</a></li> <li><a href="/wiki/4-Hydroxyestradiol" title="4-Hydroxyestradiol">4-Hydroxyestradiol</a></li> <li><a href="/wiki/4-Hydroxyestrone" title="4-Hydroxyestrone">4-Hydroxyestrone</a></li> <li><a href="/wiki/4-Methoxyestradiol" title="4-Methoxyestradiol">4-Methoxyestradiol</a></li> <li><a href="/wiki/4-Methoxyestrone" title="4-Methoxyestrone">4-Methoxyestrone</a></li> <li><a href="/wiki/5-Androstenediol" class="mw-redirect" title="5-Androstenediol">5-Androstenediol</a></li> <li><a href="/wiki/7-Keto-DHEA" title="7-Keto-DHEA">7-Oxo-DHEA</a></li> <li><a href="/wiki/7%CE%B1-Hydroxy-DHEA" title="7α-Hydroxy-DHEA">7α-Hydroxy-DHEA</a></li> <li><a href="/wiki/7%CE%B1-Methylestradiol" title="7α-Methylestradiol">7α-Methylestradiol</a></li> <li><a href="/wiki/7%CE%B2-Hydroxyepiandrosterone" title="7β-Hydroxyepiandrosterone">7β-Hydroxyepiandrosterone</a></li> <li><a href="/wiki/8,9-Dehydroestradiol" title="8,9-Dehydroestradiol">8,9-Dehydroestradiol</a></li> <li><a href="/wiki/8,9-Dehydroestrone" title="8,9-Dehydroestrone">8,9-Dehydroestrone</a></li> <li><a href="/wiki/8%CE%B2-VE2" title="8β-VE2">8β-VE2</a></li> <li><a href="/wiki/10%CE%B2,17%CE%B2-Dihydroxyestra-1,4-dien-3-one" title="10β,17β-Dihydroxyestra-1,4-dien-3-one">10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)</a></li> <li><a href="/wiki/11%CE%B2-Chloromethylestradiol" title="11β-Chloromethylestradiol">11β-Chloromethylestradiol</a></li> <li><a href="/wiki/11%CE%B2-Methoxyestradiol" title="11β-Methoxyestradiol">11β-Methoxyestradiol</a></li> <li><a href="/wiki/15%CE%B1-Hydroxyestradiol" title="15α-Hydroxyestradiol">15α-Hydroxyestradiol</a></li> <li><a href="/wiki/16-Ketoestradiol" title="16-Ketoestradiol">16-Ketoestradiol</a></li> <li><a href="/wiki/16-Ketoestrone" title="16-Ketoestrone">16-Ketoestrone</a></li> <li><a href="/wiki/16%CE%B1-Fluoroestradiol" class="mw-redirect" title="16α-Fluoroestradiol">16α-Fluoroestradiol</a></li> <li><a href="/wiki/16%CE%B1-Hydroxy-DHEA" title="16α-Hydroxy-DHEA">16α-Hydroxy-DHEA</a></li> <li><a href="/wiki/16%CE%B1-Hydroxyestrone" title="16α-Hydroxyestrone">16α-Hydroxyestrone</a></li> <li><a href="/wiki/16%CE%B1-Iodoestradiol" class="mw-redirect" title="16α-Iodoestradiol">16α-Iodoestradiol</a></li> <li><a href="/wiki/16%CE%B1-LE2" title="16α-LE2">16α-LE2</a></li> <li><a href="/wiki/16%CE%B2-Hydroxyestrone" title="16β-Hydroxyestrone">16β-Hydroxyestrone</a></li> <li><a href="/wiki/16%CE%B2,17%CE%B1-Epiestriol" title="16β,17α-Epiestriol">16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)</a></li> <li><a href="/wiki/17%CE%B1-Estradiol" title="17α-Estradiol">17α-Estradiol</a> (<a href="/wiki/Alfatradiol" title="Alfatradiol">alfatradiol</a>)</li> <li><a href="/wiki/17%CE%B1-Dihydroequilenin" title="17α-Dihydroequilenin">17α-Dihydroequilenin</a></li> <li><a href="/wiki/17%CE%B1-Dihydroequilin" title="17α-Dihydroequilin">17α-Dihydroequilin</a></li> <li><a href="/wiki/17%CE%B1-Epiestriol" title="17α-Epiestriol">17α-Epiestriol (16α-hydroxy-17α-estradiol)</a></li> <li><a href="/wiki/17%CE%B1-Ethynyl-3%CE%B1-androstanediol" title="17α-Ethynyl-3α-androstanediol">17α-Ethynyl-3α-androstanediol</a></li> <li><a href="/wiki/17%CE%B1-Ethynyl-3%CE%B2-androstanediol" title="17α-Ethynyl-3β-androstanediol">17α-Ethynyl-3β-androstanediol</a></li> <li><a href="/wiki/17%CE%B2-Dihydroequilenin" title="17β-Dihydroequilenin">17β-Dihydroequilenin</a></li> <li><a href="/wiki/17%CE%B2-Dihydroequilin" title="17β-Dihydroequilin">17β-Dihydroequilin</a></li> <li><a href="/wiki/17%CE%B2-Methyl-17%CE%B1-dihydroequilenin" title="17β-Methyl-17α-dihydroequilenin">17β-Methyl-17α-dihydroequilenin</a></li> <li><a href="/wiki/Abiraterone" class="mw-redirect" title="Abiraterone">Abiraterone</a></li> <li><a href="/wiki/Abiraterone_acetate" title="Abiraterone acetate">Abiraterone acetate</a></li> <li><a href="/wiki/Alestramustine" title="Alestramustine">Alestramustine</a></li> <li><a href="/wiki/Almestrone" title="Almestrone">Almestrone</a></li> <li><a href="/wiki/Anabolic_steroid" title="Anabolic steroid">Anabolic steroids</a> (e.g., <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> and <a href="/wiki/List_of_androgen_esters#Testosterone_esters" title="List of androgen esters">esters</a>, <a href="/wiki/Methyltestosterone" title="Methyltestosterone">methyltestosterone</a>, <a href="/wiki/Metandienone" title="Metandienone">metandienone (methandrostenolone)</a>, <a href="/wiki/Nandrolone" title="Nandrolone">nandrolone</a> and <a href="/wiki/List_of_androgen_esters#Nandrolone_esters" title="List of androgen esters">esters</a>, many others; via estrogenic metabolites)</li> <li><a href="/wiki/Atrimustine" title="Atrimustine">Atrimustine</a></li> <li><a href="/wiki/Bolandiol" title="Bolandiol">Bolandiol</a></li> <li><a href="/wiki/Bolandiol_dipropionate" title="Bolandiol dipropionate">Bolandiol dipropionate</a></li> <li><a href="/wiki/Butolame" title="Butolame">Butolame</a></li> <li><a href="/wiki/Clomestrone" title="Clomestrone">Clomestrone</a></li> <li><a href="/wiki/Cloxestradiol" title="Cloxestradiol">Cloxestradiol</a> <ul><li><a href="/wiki/Cloxestradiol_acetate" title="Cloxestradiol acetate">Cloxestradiol acetate</a></li></ul></li> <li><a href="/wiki/Conjugated_estriol" title="Conjugated estriol">Conjugated estriol</a></li> <li><a href="/wiki/Conjugated_estrogens" title="Conjugated estrogens">Conjugated estrogens</a></li> <li><a href="/wiki/Cyclodiol" title="Cyclodiol">Cyclodiol</a></li> <li><a href="/wiki/Cyclotriol" title="Cyclotriol">Cyclotriol</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA-S</a></li> <li><a href="/wiki/Ent-Estradiol" title="Ent-Estradiol"><i>ent</i>-Estradiol</a></li> <li><a href="/wiki/Epiestriol" title="Epiestriol">Epiestriol (16β-epiestriol, 16β-hydroxy-17β-estradiol)</a></li> <li><a href="/wiki/Epimestrol" title="Epimestrol">Epimestrol</a></li> <li><a href="/wiki/Equilenin" title="Equilenin">Equilenin</a></li> <li><a href="/wiki/Equilin" title="Equilin">Equilin</a></li> <li><a href="/wiki/ERA-63" title="ERA-63">ERA-63 (ORG-37663)</a></li> <li><a href="/wiki/Esterified_estrogens" title="Esterified estrogens">Esterified estrogens</a></li> <li><a href="/wiki/Estetrol" title="Estetrol">Estetrol</a></li> <li><a href="/wiki/Estradiol" title="Estradiol">Estradiol</a> <ul><li><a href="/wiki/List_of_estrogen_esters#Estradiol_esters" title="List of estrogen esters">Estradiol esters</a></li> <li><a href="/wiki/Lipoidal_estradiol" title="Lipoidal estradiol">Lipoidal estradiol</a></li> <li><a href="/wiki/Polyestradiol_phosphate" title="Polyestradiol phosphate">Polyestradiol phosphate</a></li></ul></li> <li><a href="/wiki/Estramustine" title="Estramustine">Estramustine</a></li> <li><a href="/wiki/Estramustine_phosphate" title="Estramustine phosphate">Estramustine phosphate</a></li> <li><a href="/wiki/Estrapronicate" title="Estrapronicate">Estrapronicate</a></li> <li><a href="/wiki/Estrazinol" title="Estrazinol">Estrazinol</a></li> <li><a href="/wiki/Estriol" title="Estriol">Estriol</a> <ul><li><a href="/wiki/List_of_estrogen_esters#Estriol_esters" title="List of estrogen esters">Estriol esters</a></li> <li><a href="/wiki/Polyestriol_phosphate" title="Polyestriol phosphate">Polyestriol phosphate</a></li></ul></li> <li><a href="/wiki/Estrofurate" title="Estrofurate">Estrofurate</a></li> <li><a href="/wiki/Estrogenic_substances" title="Estrogenic substances">Estrogenic substances</a></li> <li><a href="/wiki/Estromustine" title="Estromustine">Estromustine</a></li> <li><a href="/wiki/Estrone" title="Estrone">Estrone</a> <ul><li><a href="/wiki/List_of_estrogen_esters#Estrone_esters" title="List of estrogen esters">Estrone esters</a></li> <li><a href="/wiki/Estrone_methyl_ether" title="Estrone methyl ether">Estrone methyl ether</a></li> <li><a href="/wiki/Estropipate" title="Estropipate">Estropipate</a></li></ul></li> <li><a href="/wiki/Etamestrol" title="Etamestrol">Etamestrol (eptamestrol)</a></li> <li><a href="/wiki/Ethinylandrostenediol" title="Ethinylandrostenediol">Ethinylandrostenediol</a> <ul><li><a href="/wiki/Ethandrostate" title="Ethandrostate">Ethandrostate</a></li></ul></li> <li><a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">Ethinylestradiol</a> <ul><li><a href="/wiki/Ethinylestradiol_3-benzoate" class="mw-redirect" title="Ethinylestradiol 3-benzoate">Ethinylestradiol 3-benzoate</a></li> <li><a href="/wiki/Ethinylestradiol_sulfonate" title="Ethinylestradiol sulfonate">Ethinylestradiol sulfonate</a></li></ul></li> <li><a href="/wiki/Ethinylestriol" title="Ethinylestriol">Ethinylestriol</a></li> <li><a href="/wiki/Ethylestradiol" title="Ethylestradiol">Ethylestradiol</a></li> <li><a href="/wiki/Etynodiol" title="Etynodiol">Etynodiol</a></li> <li><a href="/wiki/Etynodiol_diacetate" title="Etynodiol diacetate">Etynodiol diacetate</a></li> <li><a href="/wiki/Hexolame" title="Hexolame">Hexolame</a></li> <li><a href="/wiki/Hippulin" title="Hippulin">Hippulin</a></li> <li><a href="/wiki/Hydroxyestrone_diacetate" title="Hydroxyestrone diacetate">Hydroxyestrone diacetate</a></li> <li><a href="/wiki/Lynestrenol" title="Lynestrenol">Lynestrenol</a></li> <li><a href="/wiki/Lynestrenol_phenylpropionate" title="Lynestrenol phenylpropionate">Lynestrenol phenylpropionate</a></li> <li><a href="/wiki/Mestranol" title="Mestranol">Mestranol</a></li> <li><a href="/wiki/Methylestradiol" title="Methylestradiol">Methylestradiol</a></li> <li><a href="/wiki/Moxestrol" title="Moxestrol">Moxestrol</a></li> <li><a href="/wiki/Mytatrienediol" title="Mytatrienediol">Mytatrienediol</a></li> <li><a href="/wiki/Nilestriol" title="Nilestriol">Nilestriol</a></li> <li><a href="/wiki/Norethisterone" title="Norethisterone">Norethisterone</a></li> <li><a href="/wiki/Noretynodrel" title="Noretynodrel">Noretynodrel</a></li> <li><a href="/wiki/Orestrate" title="Orestrate">Orestrate</a></li> <li><a href="/wiki/Pentolame" title="Pentolame">Pentolame</a></li> <li><a href="/wiki/Prodiame" title="Prodiame">Prodiame</a></li> <li><a href="/wiki/Prolame" title="Prolame">Prolame</a></li> <li><a href="/wiki/Promestriene" title="Promestriene">Promestriene</a></li> <li><a href="/wiki/RU-16117" title="RU-16117">RU-16117</a></li> <li><a href="/wiki/Quinestradol" title="Quinestradol">Quinestradol</a></li> <li><a href="/wiki/Quinestrol" title="Quinestrol">Quinestrol</a></li> <li><a href="/wiki/Tibolone" title="Tibolone">Tibolone</a></li></ul> <ul><li><i>Nonsteroidal:</i> <a href="/wiki/(R,R)-Tetrahydrochrysene" title="(R,R)-Tetrahydrochrysene">(R,R)-THC</a></li> <li><a href="/wiki/(S,S)-Tetrahydrochrysene" title="(S,S)-Tetrahydrochrysene">(S,S)-THC</a></li> <li><a href="/wiki/2,8-Dihydroxyhexahydrochrysene" title="2,8-Dihydroxyhexahydrochrysene">2,8-DHHHC</a></li> <li><a href="/w/index.php?title=%CE%92-LGND1&action=edit&redlink=1" class="new" title="Β-LGND1 (page does not exist)">β-LGND1</a></li> <li><a href="/wiki/%CE%92-LGND2" title="Β-LGND2">β-LGND2 (GTx-878)</a></li> <li><a href="/w/index.php?title=AC-186&action=edit&redlink=1" class="new" title="AC-186 (page does not exist)">AC-186</a></li> <li><a href="/wiki/Allenestrol" title="Allenestrol">Allenestrol</a></li> <li><a href="/wiki/Allenolic_acid" title="Allenolic acid">Allenolic acid</a></li> <li><a href="/wiki/Benzestrol" title="Benzestrol">Benzestrol</a></li> <li><a href="/wiki/Bifluranol" title="Bifluranol">Bifluranol</a></li> <li><a href="/wiki/Bisdehydrodoisynolic_acid" title="Bisdehydrodoisynolic acid">Bisdehydrodoisynolic acid</a></li> <li><a href="/wiki/Butestrol" title="Butestrol">Butestrol</a></li> <li><a href="/wiki/Carbestrol" title="Carbestrol">Carbestrol</a></li> <li><a href="/wiki/D-15414" title="D-15414">D-15414</a></li> <li><a href="/wiki/DCW234" title="DCW234">DCW234</a></li> <li><a href="/wiki/Diarylpropionitrile" title="Diarylpropionitrile">Diarylpropionitrile</a></li> <li><a href="/wiki/Dienestrol" title="Dienestrol">Dienestrol</a> <ul><li><a href="/wiki/Dienestrol_diacetate" title="Dienestrol diacetate">Dienestrol diacetate</a></li></ul></li> <li><a href="/wiki/Diethylstilbestrol" title="Diethylstilbestrol">Diethylstilbestrol</a> <ul><li><a href="/wiki/List_of_estrogen_esters#Diethylstilbestrol_esters" title="List of estrogen esters">Diethylstilbestrol esters</a></li></ul></li> <li><a href="/wiki/Dimestrol" title="Dimestrol">Dimestrol (dianisylhexene)</a></li> <li><a href="/wiki/Dimethylstilbestrol" title="Dimethylstilbestrol">Dimethylstilbestrol</a></li> <li><a href="/wiki/Doisynoestrol" title="Doisynoestrol">Doisynoestrol (fenocycline)</a></li> <li><a href="/wiki/Doisynolic_acid" title="Doisynolic acid">Doisynolic acid</a></li> <li><a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/Elacestrant" title="Elacestrant">Elacestrant</a></li> <li><a href="/wiki/ERB-196" title="ERB-196">ERB-196 (WAY-202196)</a></li> <li><a href="/wiki/Erteberel" title="Erteberel">Erteberel (SERBA-1, LY-500307)</a></li> <li><a href="/wiki/Estrobin" title="Estrobin">Estrobin (DBE)</a></li> <li><a href="/wiki/Fenestrel" title="Fenestrel">Fenestrel</a></li> <li><a href="/wiki/FERb_033" title="FERb 033">FERb 033</a></li> <li><a href="/wiki/Fosfestrol" title="Fosfestrol">Fosfestrol (diethylstilbestrol diphosphate)</a></li> <li><a href="/wiki/Furostilbestrol" title="Furostilbestrol">Furostilbestrol (diethylstilbestrol difuroate)</a></li> <li><a href="/wiki/GTx-758" title="GTx-758">GTx-758</a></li> <li><a href="/wiki/Hexestrol" title="Hexestrol">Hexestrol</a> <ul><li><a href="/wiki/List_of_estrogen_esters#Hexestrol_esters" title="List of estrogen esters">Hexestrol esters</a></li></ul></li> <li><a href="/wiki/ICI-85966" title="ICI-85966">ICI-85966 (Stilbostat)</a></li> <li><a href="/wiki/M2613" title="M2613">M2613</a></li> <li><a href="/wiki/Meso-Butestrol" title="Meso-Butestrol"><i>meso</i>-Butestrol</a></li> <li><a href="/wiki/Meso-Hexestrol" class="mw-redirect" title="Meso-Hexestrol"><i>meso</i>-Hexestrol</a></li> <li><a href="/wiki/Mestilbol" title="Mestilbol">Mestilbol</a></li> <li><a href="/wiki/Methallenestril" title="Methallenestril">Methallenestril</a></li> <li><a href="/wiki/Methestrol" title="Methestrol">Methestrol</a></li> <li><a href="/wiki/Methestrol_dipropionate" title="Methestrol dipropionate">Methestrol dipropionate</a></li> <li><a href="/wiki/Paroxypropione" title="Paroxypropione">Paroxypropione</a></li> <li><a href="/wiki/Pentafluranol" title="Pentafluranol">Pentafluranol</a></li> <li><a href="/wiki/Phenestrol" title="Phenestrol">Phenestrol</a></li> <li><a href="/wiki/Prinaberel" title="Prinaberel">Prinaberel (ERB-041, WAY-202041)</a></li> <li><a href="/wiki/Propylpyrazoletriol" title="Propylpyrazoletriol">Propylpyrazoletriol</a></li> <li><a href="/wiki/Quadrosilan" title="Quadrosilan">Quadrosilan</a></li> <li><a href="/w/index.php?title=SC-3296&action=edit&redlink=1" class="new" title="SC-3296 (page does not exist)">SC-3296</a></li> <li><a href="/wiki/SC-4289" title="SC-4289">SC-4289</a></li> <li><a href="/wiki/SERBA-2" title="SERBA-2">SERBA-2</a></li> <li><a href="/wiki/SKF-82,958" title="SKF-82,958">SKF-82,958</a></li> <li><a href="/wiki/Terfluranol" title="Terfluranol">Terfluranol</a></li> <li><a href="/wiki/Triphenylbromoethylene" title="Triphenylbromoethylene">Triphenylbromoethylene</a></li> <li><a href="/wiki/Triphenylchloroethylene" title="Triphenylchloroethylene">Triphenylchloroethylene</a></li> <li><a href="/wiki/Triphenyliodoethylene" title="Triphenyliodoethylene">Triphenyliodoethylene</a></li> <li><a href="/wiki/Triphenylmethylethylene" title="Triphenylmethylethylene">Triphenylmethylethylene (triphenylpropene)</a></li> <li><a href="/wiki/WAY-166818" title="WAY-166818">WAY-166818</a></li> <li><a href="/w/index.php?title=WAY-169916&action=edit&redlink=1" class="new" title="WAY-169916 (page does not exist)">WAY-169916</a></li> <li><a href="/wiki/WAY-200070" title="WAY-200070">WAY-200070</a></li> <li><a href="/wiki/WAY-204688" title="WAY-204688">WAY-204688 (SIM-688)</a></li> <li><a href="/wiki/WAY-214156" title="WAY-214156">WAY-214156</a></li></ul> <ul><li><i>Unknown/unsorted:</i> <a href="/wiki/ERB-26" title="ERB-26">ERB-26</a></li> <li><a href="/wiki/ERA-45" title="ERA-45">ERA-45</a></li> <li><a href="/wiki/ERB-79" title="ERB-79">ERB-79</a></li> <li><a href="/wiki/ZK-283197" title="ZK-283197">ZK-283197</a></li></ul> <ul><li><i>Xenoestrogens:</i> <a href="/wiki/Anise" title="Anise">Anise</a>-related (e.g., <a href="/wiki/Anethole" title="Anethole">anethole</a>, <a href="/wiki/Anol" title="Anol">anol</a>, <a href="/wiki/Dianethole" title="Dianethole">dianethole</a>, <a href="/wiki/Dianol" title="Dianol">dianol</a>, <a href="/wiki/Photoanethole" title="Photoanethole">photoanethole</a>)</li> <li><a href="/wiki/Chalconoid" title="Chalconoid">Chalconoids</a> (e.g., <a href="/wiki/Isoliquiritigenin" title="Isoliquiritigenin">isoliquiritigenin</a>, <a href="/wiki/Phloretin" title="Phloretin">phloretin</a>, <a href="/wiki/Phlorizin" title="Phlorizin">phlorizin (phloridzin)</a>, <a href="/wiki/Wedelolactone" title="Wedelolactone">wedelolactone</a>)</li> <li><a href="/wiki/Coumestan" title="Coumestan">Coumestans</a> (e.g., <a href="/wiki/Coumestrol" title="Coumestrol">coumestrol</a>, <a href="/wiki/Psoralidin" title="Psoralidin">psoralidin</a>)</li> <li><a href="/wiki/Flavonoid" title="Flavonoid">Flavonoids</a> (incl. <a href="/wiki/7,8-Dihydroxyflavone" class="mw-redirect" title="7,8-Dihydroxyflavone">7,8-DHF</a>, <a href="/wiki/8-Prenylnaringenin" title="8-Prenylnaringenin">8-prenylnaringenin</a>, <a href="/wiki/Apigenin" title="Apigenin">apigenin</a>, <a href="/wiki/Baicalein" title="Baicalein">baicalein</a>, <a href="/wiki/Baicalin" title="Baicalin">baicalin</a>, <a href="/wiki/Biochanin_A" title="Biochanin A">biochanin A</a>, <a href="/wiki/Calycosin" title="Calycosin">calycosin</a>, <a href="/wiki/Catechin" title="Catechin">catechin</a>, <a href="/wiki/Daidzein" title="Daidzein">daidzein</a>, <a href="/wiki/Daidzin" title="Daidzin">daidzin</a>, <a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a>, <a href="/wiki/Epigallocatechin_gallate" title="Epigallocatechin gallate">EGCG</a>, <a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">epicatechin</a>, <a href="/wiki/Equol" title="Equol">equol</a>, <a href="/wiki/Formononetin" title="Formononetin">formononetin</a>, <a href="/wiki/Glabrene" title="Glabrene">glabrene</a>, <a href="/wiki/Glabridin" title="Glabridin">glabridin</a>, <a href="/wiki/Genistein" title="Genistein">genistein</a>, <a href="/wiki/Genistin" title="Genistin">genistin</a>, <a href="/wiki/Glycitein" title="Glycitein">glycitein</a>, <a href="/wiki/Kaempferol" title="Kaempferol">kaempferol</a>, <a href="/wiki/Liquiritigenin" title="Liquiritigenin">liquiritigenin</a>, <a href="/wiki/Mirificin" title="Mirificin">mirificin</a>, <a href="/wiki/Myricetin" title="Myricetin">myricetin</a>, <a href="/wiki/Naringenin" title="Naringenin">naringenin</a>, <a href="/w/index.php?title=Penduletin&action=edit&redlink=1" class="new" title="Penduletin (page does not exist)">penduletin</a>, <a href="/wiki/Pinocembrin" title="Pinocembrin">pinocembrin</a>, <a href="/wiki/Prunetin" title="Prunetin">prunetin</a>, <a href="/wiki/Puerarin" title="Puerarin">puerarin</a>, <a href="/wiki/Quercetin" title="Quercetin">quercetin</a>, <a href="/wiki/Tectoridin" title="Tectoridin">tectoridin</a>, <a href="/wiki/Tectorigenin" title="Tectorigenin">tectorigenin</a>)</li> <li><a href="/wiki/Lavender_oil" title="Lavender oil">Lavender oil</a></li> <li><a href="/wiki/Lignan" title="Lignan">Lignans</a> (e.g., <a href="/wiki/Enterodiol" title="Enterodiol">enterodiol</a>, <a href="/wiki/Enterolactone" title="Enterolactone">enterolactone</a>, <a href="/wiki/Nyasol" title="Nyasol">nyasol (<i>cis</i>-hinokiresinol)</a>)</li> <li><a href="/wiki/Metalloestrogen" title="Metalloestrogen">Metalloestrogens</a> (e.g., <a href="/wiki/Cadmium" title="Cadmium">cadmium</a>)</li> <li><a href="/wiki/Pesticide" title="Pesticide">Pesticides</a> (e.g., <a href="/wiki/Alternariol" title="Alternariol">alternariol</a>, <a href="/wiki/Dieldrin" title="Dieldrin">dieldrin</a>, <a href="/wiki/Endosulfan" title="Endosulfan">endosulfan</a>, <a href="/wiki/Fenarimol" title="Fenarimol">fenarimol</a>, <a href="/wiki/HPTE" title="HPTE">HPTE</a>, <a href="/wiki/Methiocarb" title="Methiocarb">methiocarb</a>, <a href="/wiki/Methoxychlor" title="Methoxychlor">methoxychlor</a>, <a href="/wiki/Triclocarban" title="Triclocarban">triclocarban</a>, <a href="/wiki/Triclosan" title="Triclosan">triclosan</a>)</li> <li><a href="/wiki/Phytosteroid" title="Phytosteroid">Phytosteroids</a> (e.g., <a href="/wiki/Digitoxin" title="Digitoxin">digitoxin</a> (<a href="/wiki/Digitalis" title="Digitalis">digitalis</a>), <a href="/wiki/Diosgenin" title="Diosgenin">diosgenin</a>, <a href="/wiki/Guggulsterone" title="Guggulsterone">guggulsterone</a>)</li> <li><a href="/wiki/Phytosterol" title="Phytosterol">Phytosterols</a> (e.g., <a href="/wiki/%CE%92-sitosterol" class="mw-redirect" title="Β-sitosterol">β-sitosterol</a>, <a href="/wiki/Campesterol" title="Campesterol">campesterol</a>, <a href="/wiki/Stigmasterol" title="Stigmasterol">stigmasterol</a>)</li> <li><a href="/wiki/Resorcylic_acid_lactone" title="Resorcylic acid lactone">Resorcylic acid lactones</a> (e.g., <a href="/wiki/Zearalanone" title="Zearalanone">zearalanone</a>, <a href="/wiki/%CE%91-zearalenol" class="mw-redirect" title="Α-zearalenol">α-zearalenol</a>, <a href="/wiki/%CE%92-zearalenol" class="mw-redirect" title="Β-zearalenol">β-zearalenol</a>, <a href="/wiki/Zearalenone" title="Zearalenone">zearalenone</a>, <a href="/wiki/Zeranol" title="Zeranol">zeranol (α-zearalanol)</a>, <a href="/wiki/Taleranol" title="Taleranol">taleranol (teranol, β-zearalanol)</a>)</li> <li><a href="/wiki/Steroid" title="Steroid">Steroid</a>-like (e.g., <a href="/wiki/Deoxymiroestrol" class="mw-redirect" title="Deoxymiroestrol">deoxymiroestrol</a>, <a href="/wiki/Miroestrol" title="Miroestrol">miroestrol</a>)</li> <li><a href="/wiki/Stilbenoid" title="Stilbenoid">Stilbenoids</a> (e.g., <a href="/wiki/Resveratrol" title="Resveratrol">resveratrol</a>, <a href="/wiki/Rhaponticin" title="Rhaponticin">rhaponticin</a>)</li> <li><a href="/wiki/Synthetic_xenoestrogen" class="mw-redirect" title="Synthetic xenoestrogen">Synthetic xenoestrogens</a> (e.g., <a href="/wiki/Alkylphenol" title="Alkylphenol">alkylphenols</a>, <a href="/wiki/Bisphenol" title="Bisphenol">bisphenols</a> (e.g., <a href="/wiki/Bisphenol_A" title="Bisphenol A">BPA</a>, <a href="/wiki/Bisphenol_F" title="Bisphenol F">BPF</a>, <a href="/wiki/Bisphenol_S" title="Bisphenol S">BPS</a>), <a href="/wiki/Dichlorodiphenyltrichloroethane" class="mw-redirect" title="Dichlorodiphenyltrichloroethane">DDT</a>, <a href="/wiki/Paraben" title="Paraben">parabens</a>, <a href="/wiki/Polybrominated_biphenyl" title="Polybrominated biphenyl">PBBs</a>, <a href="/wiki/4-hydroxybenzoic_acid" class="mw-redirect" title="4-hydroxybenzoic acid">PHBA</a>, <a href="/wiki/Phthalate" class="mw-redirect" title="Phthalate">phthalates</a>, <a href="/wiki/Polychlorinated_biphenyl" title="Polychlorinated biphenyl">PCBs</a>)</li> <li>Others (e.g., <a href="/wiki/Agnuside" title="Agnuside">agnuside</a>, <a href="/w/index.php?title=Rotundifuran&action=edit&redlink=1" class="new" title="Rotundifuran (page does not exist)">rotundifuran</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Mixed<br />(<a href="/wiki/Selective_estrogen_receptor_modulators" class="mw-redirect" title="Selective estrogen receptor modulators"><abbr title="Selective estrogen receptor modulators">SERMs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Selective estrogen receptor modulators</span>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2-Phenylbenzofuran" title="2-Phenylbenzofuran">2-Phenylbenzofuran</a></li> <li><a href="/w/index.php?title=2-Phenylbenzothiophene&action=edit&redlink=1" class="new" title="2-Phenylbenzothiophene (page does not exist)">2-Phenylbenzothiophene</a></li> <li><a href="/wiki/4%27-Hydroxynorendoxifen" title="4'-Hydroxynorendoxifen">4'-Hydroxynorendoxifen</a></li> <li><a href="/wiki/27-Hydroxycholesterol" title="27-Hydroxycholesterol">27-Hydroxycholesterol</a></li> <li><a href="/wiki/Acefluranol" title="Acefluranol">Acefluranol</a></li> <li><a href="/wiki/Acolbifene" title="Acolbifene">Acolbifene</a></li> <li><a href="/wiki/Afimoxifene" title="Afimoxifene">Afimoxifene</a></li> <li><a href="/wiki/Anordiol" title="Anordiol">Anordiol</a></li> <li><a href="/wiki/Anordrin" title="Anordrin">Anordrin</a></li> <li><a href="/wiki/Arzoxifene" title="Arzoxifene">Arzoxifene</a></li> <li><a href="/wiki/Bazedoxifene" title="Bazedoxifene">Bazedoxifene</a></li> <li><a href="/wiki/Brilanestrant" title="Brilanestrant">Brilanestrant</a></li> <li><a href="/wiki/Broparestrol" title="Broparestrol">Broparestrol</a></li> <li><a href="/wiki/Camizestrant" title="Camizestrant">Camizestrant</a></li> <li><a href="/wiki/Chlorotrianisene" title="Chlorotrianisene">Chlorotrianisene</a></li> <li><a href="/wiki/Clomifene" title="Clomifene">Clomifene</a></li> <li><a href="/wiki/Clomifenoxide" title="Clomifenoxide">Clomifenoxide</a></li> <li><a href="/w/index.php?title=CN-55945-27&action=edit&redlink=1" class="new" title="CN-55945-27 (page does not exist)">CN-55945-27</a></li> <li><a href="/wiki/Cyclofenil" title="Cyclofenil">Cyclofenil</a></li> <li><a href="/w/index.php?title=D-15413&action=edit&redlink=1" class="new" title="D-15413 (page does not exist)">D-15413</a></li> <li><a href="/wiki/Desmethylchlorotrianisene" title="Desmethylchlorotrianisene">Desmethylchlorotrianisene</a></li> <li><a href="/wiki/Droloxifene" title="Droloxifene">Droloxifene</a></li> <li><a href="/wiki/Enclomifene" title="Enclomifene">Enclomifene</a></li> <li><a href="/wiki/Endoxifen" title="Endoxifen">Endoxifen</a></li> <li><a href="/wiki/Etacstil" title="Etacstil">Etacstil (GW-5638, DPC-974)</a></li> <li><a href="/wiki/Ethamoxytriphetol" title="Ethamoxytriphetol">Ethamoxytriphetol (MER-25)</a></li> <li><a href="/wiki/Femarelle" title="Femarelle">Femarelle</a></li> <li><a href="/wiki/Fispemifene" title="Fispemifene">Fispemifene</a></li> <li><a href="/w/index.php?title=GW-7604&action=edit&redlink=1" class="new" title="GW-7604 (page does not exist)">GW-7604</a></li> <li><a href="/wiki/ICI-55548" class="mw-redirect" title="ICI-55548">ICI-55548</a></li> <li><a href="/wiki/Idoxifene" title="Idoxifene">Idoxifene</a></li> <li><a href="/wiki/Lasofoxifene" title="Lasofoxifene">Lasofoxifene</a></li> <li><a href="/wiki/Levormeloxifene" title="Levormeloxifene">Levormeloxifene</a></li> <li><a href="/wiki/LN-1643" class="mw-redirect" title="LN-1643">LN-1643</a></li> <li><a href="/wiki/LN-2299" class="mw-redirect" title="LN-2299">LN-2299</a></li> <li><a href="/w/index.php?title=LY-117018&action=edit&redlink=1" class="new" title="LY-117018 (page does not exist)">LY-117018</a></li> <li><a href="/wiki/Menerba" title="Menerba">Menerba</a></li> <li><a href="/wiki/Miproxifene" title="Miproxifene">Miproxifene</a></li> <li><a href="/wiki/Miproxifene_phosphate" title="Miproxifene phosphate">Miproxifene phosphate</a></li> <li><a href="/w/index.php?title=MRL-37&action=edit&redlink=1" class="new" title="MRL-37 (page does not exist)">MRL-37</a></li> <li><a href="/wiki/Nafoxidine" title="Nafoxidine">Nafoxidine</a></li> <li><a href="/wiki/Nitromifene" title="Nitromifene">Nitromifene</a></li> <li><a href="/wiki/NNC_45-0095" title="NNC 45-0095">NNC 45-0095</a></li> <li><a href="/w/index.php?title=NNC_45-0320&action=edit&redlink=1" class="new" title="NNC 45-0320 (page does not exist)">NNC 45-0320</a></li> <li><a href="/w/index.php?title=NNC_45-0781&action=edit&redlink=1" class="new" title="NNC 45-0781 (page does not exist)">NNC 45-0781</a></li> <li><a href="/w/index.php?title=NNC_45-1506&action=edit&redlink=1" class="new" title="NNC 45-1506 (page does not exist)">NNC 45-1506</a></li> <li><a href="/wiki/Ormeloxifene" title="Ormeloxifene">Ormeloxifene</a></li> <li><a href="/wiki/Ospemifene" title="Ospemifene">Ospemifene</a></li> <li><a href="/wiki/Panomifene" title="Panomifene">Panomifene</a></li> <li><a href="/wiki/Pipendoxifene" title="Pipendoxifene">Pipendoxifene</a></li> <li><a href="/w/index.php?title=Promensil&action=edit&redlink=1" class="new" title="Promensil (page does not exist)">Promensil</a></li> <li><a href="/wiki/Raloxifene" title="Raloxifene">Raloxifene</a></li> <li><a href="/wiki/Rimostil" title="Rimostil">Rimostil (P-081)</a></li> <li><a href="/wiki/Spironolactone" title="Spironolactone">Spironolactone</a></li> <li><a href="/w/index.php?title=SS1010&action=edit&redlink=1" class="new" title="SS1010 (page does not exist)">SS1010</a></li> <li><a href="/wiki/Tamoxifen" title="Tamoxifen">Tamoxifen</a></li> <li><a href="/wiki/TAS-108" title="TAS-108">TAS-108 (SR-16234)</a></li> <li><a href="/wiki/Toremifene" title="Toremifene">Toremifene</a></li> <li><a href="/wiki/Trioxifene" title="Trioxifene">Trioxifene</a></li> <li><a href="/w/index.php?title=TZE-5323&action=edit&redlink=1" class="new" title="TZE-5323 (page does not exist)">TZE-5323</a></li> <li><a href="/w/index.php?title=U-11555A&action=edit&redlink=1" class="new" title="U-11555A (page does not exist)">U-11555A</a></li> <li><a href="/w/index.php?title=U-11634&action=edit&redlink=1" class="new" title="U-11634 (page does not exist)">U-11634</a></li> <li><a href="/w/index.php?title=Y-134&action=edit&redlink=1" class="new" title="Y-134 (page does not exist)">Y-134</a></li> <li><a href="/wiki/Zindoxifene" title="Zindoxifene">Zindoxifene</a></li> <li><a href="/wiki/Zuclomifene" title="Zuclomifene">Zuclomifene</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/(R,R)-Tetrahydrochrysene" title="(R,R)-Tetrahydrochrysene">(R,R)-THC</a></li> <li><a href="/wiki/7%CE%B2-Hydroxy-DHEA" title="7β-Hydroxy-DHEA">7β-Hydroxy-DHEA</a></li> <li><a href="/w/index.php?title=Chloroindazole&action=edit&redlink=1" class="new" title="Chloroindazole (page does not exist)">Chloroindazole</a></li> <li><a href="/wiki/Cytestrol_acetate" title="Cytestrol acetate">Cytestrol acetate</a></li> <li><a href="/w/index.php?title=EM-800&action=edit&redlink=1" class="new" title="EM-800 (page does not exist)">EM-800 (SCH-57050)</a></li> <li><a href="/wiki/Epitiostanol" title="Epitiostanol">Epitiostanol</a></li> <li><a href="/w/index.php?title=ERA-90&action=edit&redlink=1" class="new" title="ERA-90 (page does not exist)">ERA-90</a></li> <li><a href="/w/index.php?title=ERB-88&action=edit&redlink=1" class="new" title="ERB-88 (page does not exist)">ERB-88</a></li> <li><a href="/wiki/Fulvestrant" title="Fulvestrant">Fulvestrant (ICI-182780)</a></li> <li><a href="/wiki/Glyceollin" title="Glyceollin">Glyceollins</a> (<a href="/wiki/Glyceollin_I" title="Glyceollin I">I</a>, <a href="/w/index.php?title=Glyceollin_II&action=edit&redlink=1" class="new" title="Glyceollin II (page does not exist)">II</a>, <a href="/wiki/Glyceollin_III" title="Glyceollin III">III</a>, <a href="/w/index.php?title=Glyceollin_IV&action=edit&redlink=1" class="new" title="Glyceollin IV (page does not exist)">IV</a>)</li> <li><a href="/wiki/ICI-164384" title="ICI-164384">ICI-164384</a></li> <li><a href="/w/index.php?title=MDL-101906&action=edit&redlink=1" class="new" title="MDL-101906 (page does not exist)">MDL-101906</a></li> <li><a href="/wiki/Mepitiostane" title="Mepitiostane">Mepitiostane</a></li> <li><a href="/wiki/Methylepitiostanol" title="Methylepitiostanol">Methylepitiostanol</a></li> <li><a href="/wiki/Methylpiperidinopyrazole" title="Methylpiperidinopyrazole">Methylpiperidinopyrazole</a></li> <li><a href="/wiki/MIBE" title="MIBE">MIBE</a></li> <li><a href="/w/index.php?title=Oxabicycloheptene_sulfonate&action=edit&redlink=1" class="new" title="Oxabicycloheptene sulfonate (page does not exist)">Oxabicycloheptene sulfonate</a></li> <li><a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a></li> <li><a href="/wiki/PHTPP" title="PHTPP">PHTPP</a></li> <li><a href="/wiki/Prochloraz" title="Prochloraz">Prochloraz</a></li> <li><a href="/w/index.php?title=RU-39411&action=edit&redlink=1" class="new" title="RU-39411 (page does not exist)">RU-39411</a></li> <li><a href="/w/index.php?title=RU-58668&action=edit&redlink=1" class="new" title="RU-58668 (page does not exist)">RU-58668</a></li> <li><a href="/w/index.php?title=SS1020&action=edit&redlink=1" class="new" title="SS1020 (page does not exist)">SS1020</a></li> <li><a href="/wiki/TAS-108" title="TAS-108">TAS-108 (SR-16234)</a></li> <li><a href="/wiki/ZB716" title="ZB716">ZB716</a></li> <li><a href="/w/index.php?title=ZK-164015&action=edit&redlink=1" class="new" title="ZK-164015 (page does not exist)">ZK-164015</a></li> <li><a href="/w/index.php?title=ZK-191703&action=edit&redlink=1" class="new" title="ZK-191703 (page does not exist)">ZK-191703</a></li></ul> <ul><li><i>Coregulator-binding modulators:</i> <a href="/wiki/ERX-11" title="ERX-11">ERX-11</a></li></ul> <ul><li><i>Noncompetitive inhibitors:</i> <a href="/wiki/Trilostane" title="Trilostane">Trilostane</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/G_protein-coupled_estrogen_receptor" class="mw-redirect" title="G protein-coupled estrogen receptor"><abbr title="G protein-coupled estrogen receptor">GPER</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip G protein-coupled estrogen receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/2-Methoxyestradiol" title="2-Methoxyestradiol">2-Methoxyestradiol</a></li> <li><a href="/wiki/7%CE%B2-Hydroxyepiandrosterone" title="7β-Hydroxyepiandrosterone">7β-Hydroxyepiandrosterone</a></li> <li><a href="/wiki/Afimoxifene" title="Afimoxifene">Afimoxifene (4-hydroxytamoxifen)</a></li> <li><a href="/wiki/Aldosterone" title="Aldosterone">Aldosterone</a></li> <li><a href="/wiki/Atrazine" title="Atrazine">Atrazine</a></li> <li><a href="/wiki/Bisphenol_A" title="Bisphenol A">Bisphenol A</a></li> <li><a href="/wiki/Daidzein" title="Daidzein">Daidzein</a></li> <li><a href="/wiki/DDT" title="DDT">DDT</a> (<a href="/wiki/P,p%27-DDT" class="mw-redirect" title="P,p'-DDT">p,p'-DDT</a>, <a href="/w/index.php?title=O%27,p%27-DDE&action=edit&redlink=1" class="new" title="O',p'-DDE (page does not exist)">o',p'-DDE</a>)</li> <li><a href="/wiki/Diarylpropionitrile" title="Diarylpropionitrile">Diarylpropionitrile</a></li> <li><a href="/wiki/Equol" title="Equol">Equol</a></li> <li><a href="/wiki/Estradiol" title="Estradiol">Estradiol</a></li> <li><a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">Ethinylestradiol</a></li> <li><a href="/wiki/Fulvestrant" title="Fulvestrant">Fulvestrant (ICI-182780)</a></li> <li><a href="/w/index.php?title=G-1_(drug)&action=edit&redlink=1" class="new" title="G-1 (drug) (page does not exist)">G-1</a></li> <li><a href="/wiki/Genistein" title="Genistein">Genistein</a></li> <li><a href="/w/index.php?title=GPER-L1&action=edit&redlink=1" class="new" title="GPER-L1 (page does not exist)">GPER-L1</a></li> <li><a href="/w/index.php?title=GPER-L2&action=edit&redlink=1" class="new" title="GPER-L2 (page does not exist)">GPER-L2</a></li> <li><a href="/wiki/Hydroxytyrosol" title="Hydroxytyrosol">Hydroxytyrosol</a></li> <li><a href="/wiki/Kepone" class="mw-redirect" title="Kepone">Kepone</a></li> <li><a href="/wiki/Niacin" title="Niacin">Niacin</a></li> <li><a href="/wiki/Niacinamide" class="mw-redirect" title="Niacinamide">Niacinamide</a></li> <li><a href="/wiki/Nonylphenol" title="Nonylphenol">Nonylphenol</a></li> <li><a href="/wiki/Oleuropein" title="Oleuropein">Oleuropein</a></li> <li><a href="/wiki/Polychlorinated_biphenyl" title="Polychlorinated biphenyl">PCBs</a> (<a href="/w/index.php?title=2,2%27,5%27-PCB-4-OH&action=edit&redlink=1" class="new" title="2,2',5'-PCB-4-OH (page does not exist)">2,2',5'-PCB-4-OH</a>)</li> <li><a href="/wiki/Propylpyrazoletriol" title="Propylpyrazoletriol">Propylpyrazoletriol</a></li> <li><a href="/wiki/Quercetin" title="Quercetin">Quercetin</a></li> <li><a href="/wiki/Raloxifene" title="Raloxifene">Raloxifene</a></li> <li><a href="/wiki/Resveratrol" title="Resveratrol">Resveratrol</a></li> <li><a href="/w/index.php?title=STX_(drug)&action=edit&redlink=1" class="new" title="STX (drug) (page does not exist)">STX</a></li> <li><a href="/wiki/Tamoxifen" title="Tamoxifen">Tamoxifen</a></li> <li><a href="/wiki/Tectoridin" title="Tectoridin">Tectoridin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CCL18" title="CCL18">CCL18</a></li> <li><a href="/wiki/Estriol" title="Estriol">Estriol</a></li> <li><a href="/w/index.php?title=G-15_(drug)&action=edit&redlink=1" class="new" title="G-15 (drug) (page does not exist)">G-15</a></li> <li><a href="/w/index.php?title=G-36_(drug)&action=edit&redlink=1" class="new" title="G-36 (drug) (page does not exist)">G-36</a></li> <li><a href="/wiki/MIBE" title="MIBE">MIBE</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Unknown</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Diethylstilbestrol" title="Diethylstilbestrol">Diethylstilbestrol</a></li> <li><a href="/wiki/Zearalenone" title="Zearalenone">Zearalenone</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></dd> <dd><a href="/wiki/Template:Estrogens_and_antiestrogens" title="Template:Estrogens and antiestrogens">Estrogens and antiestrogens</a></dd> <dd><a href="/wiki/Template:Androgen_receptor_modulators" title="Template:Androgen receptor modulators">Androgen receptor modulators</a></dd> <dd><a href="/wiki/Template:Progesterone_receptor_modulators" title="Template:Progesterone receptor modulators">Progesterone receptor modulators</a></dd> <dd><a href="/wiki/List_of_steroidal_estrogens" class="mw-redirect" title="List of steroidal estrogens">List of estrogens</a></dd></dl> </div></td></tr></tbody></table></div>    </div><noscript><img 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