Cultrex BME | Extracellular Matrix

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paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:h1_2_2_text_to_media:field_indv_h1"> <div><h1>Cultrex Extracellular Matrices for 2-D & 3-D Cell Culture</h1></div> </div> <div class="field_block:paragraph:h1_2_2_text_to_media:field_lg_sngl_frmtd_text_global"> <div><p>Cultrex™ extracellular matrices and purified matrix proteins are known for their <strong>performance, quality, low endotoxin levels, reliable supply, lot-to-lot consistency,</strong> and are designed to meet the specific needs of a diverse range of fields. </p></div> </div> <div class="field_block:paragraph:h1_2_2_text_to_media:field_call_to_action_global"> <a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/sample-request" class="btn btn-primary" type="link"> Request an Extracellular 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</li> <li> Cultrex BME </li> </ol> </nav> </div> </div> </div> </div> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <article> <div> <div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins#background">Background Information</a> | <a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins#feature">Featured ECM</a> | <a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins#portfolio">ECM Portfolio</a> | <a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins#related">Related Products</a> | <a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins#resources">ECM Resources</a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="background"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--full-page-text-with-media mb-4 paragraph--view-mode--default"> <div><h2>What is a Basement Membrane Extract or Extracellular Matrix?</h2></div> <div><p>Cultrex Basement Membrane Extracts (BME) are solubilized extracellular matrices (ECM) purified from the Englebreth-Holm-Swarm (EHS) murine tumor and are rich in extracellular matrix proteins, such as laminin, collagen IV, entactin, and heparan sulfate proteoglycans. Polymerizing at 37 °C, they provide structural support for cells, plus play an important role in establishing tissue organization by influencing cell adhesion, proliferation, migration, and differentiation. Basement membranes are used to promote and maintain a differentiated phenotype in endothelial cells, epithelial cells, smooth muscle cells, glandular cells, and neurons, and are also used for angiogenesis assays, cell invasion assays, neurite outgrowth assays, and <em>in vivo</em> tumorigenicity assays. Multiple different formats of Cultrex Basement Membrane Extract have been qualified for specific 2-D and 3-D cell culture applications. Most formulations are also available with reduced growth factor content and with or without phenol red. Purified extracellular matrix proteins are also available.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="feature"></a></p></div> </div> </div> <div> <section class="paragraph paragraph--type--full-width-banner-with-image mb-4 paragraph--view-mode--default paragraph-background-color--dark"> <div class="banner_background_image" data-bgimage="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/organoids5-img-bg.jpg" style="background-repeat: no-repeat;"> <div> <div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/organoids5-img.png" alt="Organoids cultured in Cultrex UltiMatrix" loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div><h2>Featured Extracellular Matrix:<br>Cultrex UltiMatrix RGF BME </h2></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Cultrex UltiMatrix has been meticulously crafted to cater to the evolving demands of cell culture. With its enhanced consistency and quality, UltiMatrix is rapidly emerging as the hydrogel of choice, offering remarkable efficacy across various applications including organoid cell culture, spheroid formation, induced pluripotent stem cell expansion and differentiation, and more.</p></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_call_to_action_global"> <a href="/p/cell-culture/cultrex-ultimatrix-reduced-growth-factor-basement-membrane-extract_bme001-05" class="btn btn-primary" type="link"> Learn More About Cultrex UltiMatrix </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p><a name="portfolio"></a></p></div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default"> <div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Select the ECM Optimized for Your Research</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>For additional help selecting or learning how to use Cultrex ECM products, visit the <a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/cell-culture-matrix-for-your-research">Cultrex ECM Selection and Use Guide</a>.</p> <h3> </h3> <h3>Cultrex Basement Membrane Extracts</h3> <figure class="responsive-figure-table"><table class="table table-striped"> <tbody> <tr> <td><a href="/p/cell-culture/cultrex-ultimatrix-reduced-growth-factor-basement-membrane-extract_bme001-05">UltiMatrix BME</a></td> <td><a href="/p/cell-culture/cultrex-basement-membrane-extract-pathclear_3432-010-01">BME</a> (<a href="/p/cell-culture/cultrex-basement-membrane-extract-pathclear-with-phenol-red_3432-010-01p">With Phenol Red</a>)</td> <td><a href="/p/cell-culture/cultrex-reduced-growth-factor-basement-membrane-extract-pathclear_3433-010-01">RGF BME</a> (<a href="/p/cell-culture/cultrex-reduced-growth-factor-basement-membrane-extract-pathclear-with-phenol-red_3433-010-01p">With Phenol Red</a>)</td> </tr> <tr> <td><a href="/p/cell-culture/cultrex-basement-membrane-extract-type-2-pathclear_3532-010-02">BME, Type 2</a> (<a href="/p/cell-culture/cultrex-basement-membrane-extract-type-2-pathclear-with-phenol-red_3532-010-02p">With Phenol Red</a>)</td> <td><a href="/p/cell-culture/cultrex-reduced-growth-factor-basement-membrane-extract-type-2-pathclear_3533-010-02">RGF BME, Type 2</a> (<a href="/p/cell-culture/cultrex-reduced-growth-factor-basement-membrane-extract-type-2-pathclear-with-phenol-red_3533-010-02p">With Phenol Red</a>)</td> <td><a href="/p/cell-culture/cultrex-reduced-growth-factor-basement-membrane-extract-type-2-select_3536-005-02">RGF BME, Type 2, Select</a></td> </tr> <tr> <td><a href="/p/cell-culture/cultrex-basement-membrane-extract-type-3-pathclear_3632-010-02">BME, Type 3</a> (<a href="/p/cell-culture/cultrex-basement-membrane-extract-type-3-pathclear-with-phenol-red_3632-010-02p">With Phenol Red</a>)</td> <td><a href="/p/cell-culture/cultrex-3-d-culture-matrix-reduced-growth-factor-basement-membrane-extract-pathclear_3445-010-01">3-D Culture Matrix RGF BME</a></td> <td><a href="/p/cell-culture/cultrex-reduced-growth-factor-basement-membrane-extract-type-r1_3433-010-r1">RGF BME, Type R1</a></td> </tr> <tr> <td><a href="/p/cell-culture/cultrex-stem-cell-qualified-reduced-growth-factor-basement-membrane-extract_3434-010-02">Stem Cell Qualified RGF BME</a></td> <td><a href="/p/cell-culture/cultrex-readybme-stem-cell-qualified-reduced-growth-factor_3434-050-rtu">ReadyBME, Stem Cell Qualified, RGF</a></td> <td> </td> </tr> </tbody> </table></figure> <h3>Cultrex ECM Proteins</h3> <figure class="responsive-figure-table"><table class="table table-striped"> <tbody> <tr> <td><a href="/search?keywords=vitronectin&category_attr=Proteins%20and%20Enzymes&common_name=Vitronectin">Vitronectin</a></td> <td><a href="/p/cell-culture/cultrex-rat-collagen-i_3440-100-01">Rat Collagen I</a></td> <td><a href="/p/cell-culture/cultrex-rat-collagen-i-lower-viscosity_3443-100-01">Rat Collagen I, Low Viscosity</a></td> <td><a href="/p/cell-culture/cultrex-3-d-culture-matrix-rat-collagen-i_3447-020-01">Rat Collagen I, 3-D Culture Extract</a></td> </tr> <tr> <td><a href="/search?keywords=mouse%20laminin%20i&common_name=Laminin-1&sub_category=Basement%20Membrane%20Extracts">Mouse Laminin I</a></td> <td><a href="/p/cell-culture/cultrex-3-d-culture-matrix-laminin-i_3446-005-01">Laminin I, 3-D Culture Extract</a></td> <td><a href="/p/cell-culture/cultrex-mouse-collagen-iv_3410-010-02">Mouse Collagen IV</a></td> <td> </td> </tr> </tbody> </table></figure></div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-3-media-to-text paragraph--view-mode--default mb-4 p-3"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--25-75"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_indv_media"> <div> <a href="https://www.bio-techne.com/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/sample-request" title="Request a Cultrex ECM Sample" > <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/bme-in-ice-525x315.jpg" alt="extracellular matrix products in ice" loading="lazy" > </a> </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:1_3_media_to_text:field_header_2_global"> <div><h2>Experience the Quality of Cultrex Before You Buy!</h2></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_lg_sngl_frmtd_text_global"> <div><p>Discover your new favorite matrix today! Experience how Cultrex Basement Membrane Extracts can enhance the performance of your cell cultures. </p></div> </div> <div class="field_block:paragraph:1_3_media_to_text:field_call_to_action_global"> <a href="/reagents/cell-culture-reagents/cultrex-bme-and-ecm-proteins/sample-request" class="btn btn-primary" type="link"> Request a Cultrex ECM Sample </a> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--section paragraph--view-mode--default mb-4"> <div> <div> <div class="paragraph paragraph--type--header"> <div> <div><h2>Choose Cultrex: An Extracellular Matrix That Prioritizes Quality</h2></div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><p>When you choose Cultrex BME matrices, you are choosing a quality reagent. Being able to trust in the efficacy of your starting materials gives your experiments the best chance of success. Cultrex's rigorous quality testing enables you to obtain results that are dependable, representative, and consistent. See the data examples below and have confidence when you choose Cultrex as your cellular matrix.</p></div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/graphs/Concentration-and-Endotoxin-by-Lot.jpg" alt="Plot shows consistently low endotoxin levels and high protein concentrations across 20 lots of Cultrex UltiMatrix." loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><h4> </h4> <h4>Consistent Endotoxin Levels and Protein Concentrations</h4> <p> </p> <p>This graph shows consistently low levels of endotoxin across 20 lots of Cultrex UltiMatrix. The graph also demonstrates the consistency of protein concentration from lot to lot, highlighting the product's ability to maintain higher, constant protein levels. Cultrex UltiMatrix is designed to provide consistent protein concentration for reliable experimental outcomes.</p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/graphs/Cultrex-UltiMatrix-Displays-Optimized-Tensile-Strength-in-3D-Culture-Applications.png" alt="UltiMatrix displays consistent gelling rates and high tensile strength compared to competitor ECM." loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><h4> </h4> <h4> </h4> <p> </p> <h4>Cultrex UltiMatrix Displays Optimized Tensile Strength in 3D Culture Applications</h4> <p> </p> <p>Cultrex UltiMatrix displays consistent gelling rates and tensile strength (storage modulus) compared to competitor ECM.</p></div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--_-2-media-to-text mb-4 paragraph--view-mode--default"> <div class="container-fluid container-wide"> <div class="layout layout--twocol-section layout--twocol-section--50-50"> <div class="layout__region layout__region--first"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_indv_media"> <div> <img src="https://resources.bio-techne.com/bio-techne-assets/images/products/protein-composition-graph.png" alt="SDS-PAGE shows that protein composition is consistent across lots when compared with competitors." loading="lazy" > </div> </div> </div> </div> <div class="layout__region layout__region--second"> <div class="hero-content-wrap"> <div class="field_block:paragraph:2_2_media_to_text:field_header_2_global"> <div></div> </div> <div class="field_block:paragraph:2_2_media_to_text:field_lg_sngl_frmtd_text_global"> <div><h4> </h4> <h4>Protein Composition is Consistent Across Lots</h4> <p> </p> <p>Entactin, Laminin, and Collagen are the three major ECM components of Cultrex UltiMatrix, at 13.3%, 38.8%, and 44.6%, respectively. Samples were run using a WES 66-440 KDa 25 capillary cartridge separation module. Expression of component proteins is more consistent across lots compared with competitors.</p> <p> </p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div> <div class="thin-banner banner_wrapper"> <div class="banner-dark"> <div> <div><h2>Learn Reliable Organoid Culturing Techniques</h2></div> <a href="/resources/webinars/culturing-organoids-and-spheroids" > <button type="button" class="btn btn-primary"> Watch Organoid Webinar </button> </a> </div> </div> </div> </div> <div> <div class="testimonial"> <div > <div class="row"> <div class="col-md-4"> <div class="left-title"> <h2>Customer Success Stories</h2> </div> </div> <div class="col-md-8"> <div class="right-card bg-white border rounded p-5 mb-4"> <div class="carousel slide" id="carouselIndicators" data-ride="carousel"> <div class="row"> <div class="col-md-12"> <div class="carousel-inner"> <div class="carousel-item active">  <div class="paragraph paragraph--type--individual-testimonial individual-testimonial paragraph--view-mode--default"> <div class="testimonial-info-group"> <div class="row"> <div class="col-lg-3 offset-lg-1 col-sm-12"> <div class="text-center text-lg-left"> <div class="individual-testimonial__headshot"> <div class="blazy blazy--field blazy--field-indv-img blazy--field-indv-img--default" data-blazy=""> <div data-b-token="b-51feda6cf48" class="media media--blazy media--rendered media--resourcesbio-techne media--bundle--remote-image"><img src='https://resources.bio-techne.com/bio-techne-assets/images/brands/iconuser230.png' alt='Testimonials Profile Placeholder Image'> </div> </div> </div> </div> </div> <div class="col-10 offset-1 col-sm-10 offset-sm-1 col-md-8 offset-md-2 col-lg-6 offset-lg-0"> <div class="testimonial-info"> <div class="individual-testimonial__info"> <span class="individual-testimonial__name"> Brett M. Hall </span><br/> <span class="individual-testimonial__position"> Asst. Prof. of Pediatrics at the OSU School of Medicine </span><br/> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-2 quote-column text-center"> <img class="quote" loading="lazy" src="/themes/custom/bio_techne_global/images/testimonials-quote.svg"/> </div> </div> </div> <div class="row"> <div class="col-10 offset-1 col-md-10 offset-md-1 col-sm-10"> <div class="individual-testimonial__testimonial"> "After comparing head-to-head Cultrex™ BME and BD Biosciences Matrigel™ BME, the Cultrex equaled or exceeded BD's Matrigel BME product in our 3D Tumor Growth Assay (TGA). Cultrex BME has a higher average BME concentration, and superior lot-to-lot consistency with respect to tumor cell growth in the 3D TGA".     </div> </div> </div> </div> </div> <div class="carousel-item">  <div class="paragraph paragraph--type--individual-testimonial individual-testimonial paragraph--view-mode--default"> <div class="testimonial-info-group"> <div class="row"> <div class="col-lg-3 offset-lg-1 col-sm-12"> <div class="text-center text-lg-left"> <div class="individual-testimonial__headshot"> <div class="blazy blazy--field blazy--field-indv-img blazy--field-indv-img--default" data-blazy=""> <div data-b-token="b-51feda6cf48" class="media media--blazy media--rendered media--resourcesbio-techne media--bundle--remote-image"><img src='https://resources.bio-techne.com/bio-techne-assets/images/brands/iconuser230.png' alt='Testimonials Profile Placeholder Image'> </div> </div> </div> </div> </div> <div class="col-10 offset-1 col-sm-10 offset-sm-1 col-md-8 offset-md-2 col-lg-6 offset-lg-0"> <div class="testimonial-info"> <div class="individual-testimonial__info"> <span class="individual-testimonial__name"> Henry Lopez </span><br/> <span class="individual-testimonial__position"> CSO of MuriGenics Inc. </span><br/> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-2 quote-column text-center"> <img class="quote" loading="lazy" src="/themes/custom/bio_techne_global/images/testimonials-quote.svg"/> </div> </div> </div> <div class="row"> <div class="col-10 offset-1 col-md-10 offset-md-1 col-sm-10"> <div class="individual-testimonial__testimonial"> "We have used Cultrex in all of our in vitro (endothelial cell tube formation, stem cell differentiation), ex vivo (aortic explant outgrowth, salivary gland organ differentiation), and in vivo assays (subcutaneous angiogenesis, tumor growth promotion) where it has worked well with highly reproducible findings".       </div> </div> </div> </div> </div> <div class="carousel-item">  <div class="paragraph paragraph--type--individual-testimonial individual-testimonial paragraph--view-mode--default"> <div class="testimonial-info-group"> <div class="row"> <div class="col-lg-3 offset-lg-1 col-sm-12"> <div class="text-center text-lg-left"> <div class="individual-testimonial__headshot"> <div class="blazy blazy--field blazy--field-indv-img blazy--field-indv-img--default" data-blazy=""> <div data-b-token="b-51feda6cf48" class="media media--blazy media--rendered media--resourcesbio-techne media--bundle--remote-image"><img src='https://resources.bio-techne.com/bio-techne-assets/images/brands/iconuser230.png' alt='Testimonials Profile Placeholder Image'> </div> </div> </div> </div> </div> <div class="col-10 offset-1 col-sm-10 offset-sm-1 col-md-8 offset-md-2 col-lg-6 offset-lg-0"> <div class="testimonial-info"> <div class="individual-testimonial__info"> <span class="individual-testimonial__name"> Robert Barratt </span><br/> <span class="individual-testimonial__position"> F. Widjaja Foundation-IBIRI | Cedars-Sanai Medical Center </span><br/> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-2 quote-column text-center"> <img class="quote" loading="lazy" src="/themes/custom/bio_techne_global/images/testimonials-quote.svg"/> </div> </div> </div> <div class="row"> <div class="col-10 offset-1 col-md-10 offset-md-1 col-sm-10"> <div class="individual-testimonial__testimonial"> "I used UltiMatrix to culture iPSC-derived human intestinal organoids, and the organoids looked absolutely fantastic in it! I’ve been very pleased with the product - it’s very consistent and I’ve had no problems with it." </div> </div> </div> </div> </div> <div class="carousel-item">  <div class="paragraph paragraph--type--individual-testimonial individual-testimonial paragraph--view-mode--default"> <div class="testimonial-info-group"> <div class="row"> <div class="col-lg-3 offset-lg-1 col-sm-12"> <div class="text-center text-lg-left"> <div class="individual-testimonial__headshot"> <div class="blazy blazy--field blazy--field-indv-img blazy--field-indv-img--default" data-blazy=""> <div data-b-token="b-51feda6cf48" class="media media--blazy media--rendered media--resourcesbio-techne media--bundle--remote-image"><img src='https://resources.bio-techne.com/bio-techne-assets/images/brands/iconuser230.png' alt='Testimonials Profile Placeholder Image'> </div> </div> </div> </div> </div> <div class="col-10 offset-1 col-sm-10 offset-sm-1 col-md-8 offset-md-2 col-lg-6 offset-lg-0"> <div class="testimonial-info"> <div class="individual-testimonial__info"> <span class="individual-testimonial__name"> Dr. Amar M. Singh </span><br/> <span class="individual-testimonial__position"> University of Georgia </span><br/> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-2 quote-column text-center"> <img class="quote" loading="lazy" src="/themes/custom/bio_techne_global/images/testimonials-quote.svg"/> </div> </div> </div> <div class="row"> <div class="col-10 offset-1 col-md-10 offset-md-1 col-sm-10"> <div class="individual-testimonial__testimonial"> “Cultrex ReadyBME has worked very well for our lab. H9 hESCs (WA09) were grown on Cultrex ReadyBME and was directly compared side-by-side to our normal basement membrane. So far, I’ve grown the cells for more than 5 passages and haven’t observed any changes in proliferation rate, viability, cell morphology or the increased appearance of differentiated cells.”     </div> </div> </div> </div> </div> <div class="carousel-item">  <div class="paragraph paragraph--type--individual-testimonial individual-testimonial paragraph--view-mode--default"> <div class="testimonial-info-group"> <div class="row"> <div class="col-lg-3 offset-lg-1 col-sm-12"> <div class="text-center text-lg-left"> <div class="individual-testimonial__headshot"> <div class="blazy blazy--field blazy--field-indv-img blazy--field-indv-img--default" data-blazy=""> <div data-b-token="b-51feda6cf48" class="media media--blazy media--rendered media--resourcesbio-techne media--bundle--remote-image"><img src='https://resources.bio-techne.com/bio-techne-assets/images/brands/iconuser230.png' alt='Testimonials Profile Placeholder Image'> </div> </div> </div> </div> </div> <div class="col-10 offset-1 col-sm-10 offset-sm-1 col-md-8 offset-md-2 col-lg-6 offset-lg-0"> <div class="testimonial-info"> <div class="individual-testimonial__info"> <span class="individual-testimonial__name"> Michael K. Dame </span><br/> <span class="individual-testimonial__position"> Associate Director | Translational Tissue Modeling Institute </span><br/> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-2 quote-column text-center"> <img class="quote" loading="lazy" src="/themes/custom/bio_techne_global/images/testimonials-quote.svg"/> </div> </div> </div> <div class="row"> <div class="col-10 offset-1 col-md-10 offset-md-1 col-sm-10"> <div class="individual-testimonial__testimonial"> “Ultimatrix is unique in its ability to bead up to form a droplet at even low concentrations. We have found that preparing protein concentrations below 8 mg/mL for other commercial ECMs causes 3-dimensional tissues, such as intestinal organoids, to sink to the plastic leading to differentiation and cell death, while UltiMatrix supports healthy normal growth.”   </div> </div> </div> </div> </div> <div class="carousel-item">  <div class="paragraph paragraph--type--individual-testimonial individual-testimonial paragraph--view-mode--default"> <div class="testimonial-info-group"> <div class="row"> <div class="col-lg-3 offset-lg-1 col-sm-12"> <div class="text-center text-lg-left"> <div class="individual-testimonial__headshot"> <div class="blazy blazy--field blazy--field-indv-img blazy--field-indv-img--default" data-blazy=""> <div data-b-token="b-809833d41b6" class="media media--blazy media--rendered media--resourcesbio-techne media--bundle--remote-image"><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/ken-diffenderfer-final.jpg' alt='Photograph of Ken Diffenderfer, Director of the Stem Cell Core Facility at the Salk Institute in La Jolla, CA, USA'> </div> </div> </div> </div> </div> <div class="col-10 offset-1 col-sm-10 offset-sm-1 col-md-8 offset-md-2 col-lg-6 offset-lg-0"> <div class="testimonial-info"> <div class="individual-testimonial__info"> <span class="individual-testimonial__name"> Ken Diffenderfer </span><br/> <span class="individual-testimonial__position"> Director of the Stem Cell Core Facility | Salk Institute </span><br/> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-2 quote-column text-center"> <img class="quote" loading="lazy" src="/themes/custom/bio_techne_global/images/testimonials-quote.svg"/> </div> </div> </div> <div class="row"> <div class="col-10 offset-1 col-md-10 offset-md-1 col-sm-10"> <div class="individual-testimonial__testimonial"> “In 2015, we started to evaluate Cultrex BME as an alternative to Matrigel<sup>®</sup>. At that time, we pursued some rigorous quality control testing comparing Cultrex to Matrigel. And in that, we tested 10 cell lines for over 20 passages through various functional assays, and found it to be an incredibly stable and consistent product. Since that time, we have been lot testing Cultrex BME for individual lot purchases, as we consume that reagent. And we have tested approximately 20 lots of Cultrex BME in that time. Through those 20 lots, not a single one has failed our internal QC paradigm.” </div> </div> </div> </div> </div> <div class="carousel-item">  <div class="paragraph paragraph--type--individual-testimonial individual-testimonial paragraph--view-mode--default"> <div class="testimonial-info-group"> <div class="row"> <div class="col-lg-3 offset-lg-1 col-sm-12"> <div class="text-center text-lg-left"> <div class="individual-testimonial__headshot"> <div class="blazy blazy--field blazy--field-indv-img blazy--field-indv-img--default" data-blazy=""> <div data-b-token="b-2c3c5e63245" class="media media--blazy media--rendered media--resourcesbio-techne media--bundle--remote-image"><img src='https://resources.bio-techne.com/bio-techne-assets/images/research-areas/jens-photo-final-v5.jpg' alt='Photograph of Jens Pushof from the Hans Clevers lab at the Hubrecht Institute in The Netherlands'> </div> </div> </div> </div> </div> <div class="col-10 offset-1 col-sm-10 offset-sm-1 col-md-8 offset-md-2 col-lg-6 offset-lg-0"> <div class="testimonial-info"> <div class="individual-testimonial__info"> <span class="individual-testimonial__name"> Jens Puschhof </span><br/> <span class="individual-testimonial__position"> Hans Clevers Lab | Hubrecht Institute </span><br/> </div> </div> </div> <div class="col-12 col-sm-12 col-md-12 col-lg-2 quote-column text-center"> <img class="quote" loading="lazy" src="/themes/custom/bio_techne_global/images/testimonials-quote.svg"/> </div> </div> </div> <div class="row"> <div class="col-10 offset-1 col-md-10 offset-md-1 col-sm-10"> <div class="individual-testimonial__testimonial"> “Our research is greatly facilitated by Bio-Techne products. The various organoid systems and co-cultures are all performed in or on R&D Systems Cultrex Reduced Growth Factor BME with great results. Even for more exotic organoids, such as snake venom gland organoids, we could achieve breakthroughs with R&D Systems growth factors and BME as well as spatial visualization of toxin transcripts using ACD’s RNAScope.”   </div> </div> </div> </div> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <ol class="carousel-indicators"> <li data-target="#carouselIndicators" data-slide-to="0" class="active"> </li> <li data-target="#carouselIndicators" data-slide-to="1"> </li> <li data-target="#carouselIndicators" data-slide-to="2"> </li> <li data-target="#carouselIndicators" data-slide-to="3"> </li> <li data-target="#carouselIndicators" data-slide-to="4"> </li> <li data-target="#carouselIndicators" data-slide-to="5"> </li> <li data-target="#carouselIndicators" data-slide-to="6"> </li> </ol> </div> </div> <a class="carousel-control-prev" href="#carouselIndicators" role="button" data-slide="prev"> <span class="carousel-control-prev-icon" aria-hidden="true"></span> <span class="sr-only">Previous</span> </a> <a class="carousel-control-next" href="#carouselIndicators" role="button" data-slide="next"> <span class="carousel-control-next-icon" aria-hidden="true"></span> <span class="sr-only">Next</span> </a> </div> </div> </div> </div> </div> </div> <div> <div class="paragraph paragraph--type--freeform mb-4 paragraph--view-mode--default"> <div><h2> </h2> <h2>Featured Products and Promotions<a name="related"></a></h2></div> </div> </div> <div> <div class="paragraph paragraph--type--card-paragraph paragraph--view-mode--default card-para-default"> <div class="row card_row"> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/reagents/proteins/organoid-culture-proteins" > <div class="teaser-card-image-crop mb-3"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/proteins-teaser-boxes.jpg" alt="Ribon structure of Recombinant Human SCF Protein" loading="lazy" > </div> </a> <a class="card_title_link" href="/reagents/proteins/organoid-culture-proteins" > <h3 class="card_title_htag"> <div>Proteins for Organoid Culture</div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>Enhance your research outcomes by designing tailor-made culture conditions with the addition of carefully selected cytokines and growth factors.</p></div> </div> <div class="card-bottom-link"> <div> <a href="/reagents/proteins/organoid-culture-proteins" > View Organoid Culture Proteins </a> </div> </div> </div> </div> </div> <div class="col-md-4"> <div class="h-100"> <div class="bg-white border rounded flex-column d-flex h-100"> <a href="/research-areas/stem-cells/ipsc" > <div class="teaser-card-image-crop mb-3"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/research-areas/induced-pluripotent-stem-cells-teaser-boxes.jpg" alt="iPSC rendering shows round cell with long cytoplasmic tails" loading="lazy" > </div> </a> <a class="card_title_link" href="/research-areas/stem-cells/ipsc" > <h3 class="card_title_htag"> <div>Induced Pluripotent Stem Cells (iPSC)</div> </h3> </a> <div class="card_description flex-grow-1"> <div><p>iPSCs possess the remarkable ability to differentiate and consequently can provide a foundation for many types of research. 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