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href="/SahapatBarusrux/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Thailand Professor in Medical Science and  Natural product<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="12754608" href="https://www.academia.edu/Documents/in/Multidisciplinary"><div id="js-react-on-rails-context" style="display:none" 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class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) ce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) cell line</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96111211"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96111211, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } 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$a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96110855"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96110855/Melatonin_induces_apoptosis_through_biomolecular_changes_in_SK_LU_1_human_lung_adenocarcinoma_cells"><img alt="Research paper thumbnail of Melatonin induces apoptosis through biomolecular changes, in SK-LU-1 human lung adenocarcinoma cells" class="work-thumbnail" src="https://attachments.academia-assets.com/98100174/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96110855/Melatonin_induces_apoptosis_through_biomolecular_changes_in_SK_LU_1_human_lung_adenocarcinoma_cells">Melatonin induces apoptosis through biomolecular changes, in SK-LU-1 human lung adenocarcinoma cells</a></div><div class="wp-workCard_item"><span>Cell Proliferation</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="69db8b4fd23dc7d82e5fb395e199f7ff" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98100174,"asset_id":96110855,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98100174/download_file?st=MTczMjk3OTkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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Thus, we investigated its induction of apoptosis through biomolecular changes (lipid, protein and nucleic acid/DNA) in the SK-LU-1 human lung cancer cell line. Materials and methods: We used Fourier transform infrared (FTIR) microspectroscopy, and conventional methods, to confirm changes in lipid (annexin V/PI staining for membrane alteration), protein (caspase-3/7 protein activity) and DNA (DAPI staining for DNA fragmentation). Results: We observed from FTIR data that melatonin increased lipid content and reduced intensity of nucleic acid/DNA, confirmed by annexin V/PI and DAPI respectively. Secondary protein structure at 1656 cm À1 (a-helix) was reduced and peak position of b-sheet structure (1637 cm À1) was shifted to lower frequency. Alteration in apoptotic proteins was demonstrated via caspase-3/7 activity induction. Conclusions: High melatonin concentration exerted anti-cancer effects by changing biomolecular structure of lipids, nucleic acids and proteins, supporting its enhancement of apoptotic induction.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Cell Proliferation","grobid_abstract_attachment_id":98100174},"translated_abstract":null,"internal_url":"https://www.academia.edu/96110855/Melatonin_induces_apoptosis_through_biomolecular_changes_in_SK_LU_1_human_lung_adenocarcinoma_cells","translated_internal_url":"","created_at":"2023-02-01T06:54:31.840-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98100174,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98100174/thumbnails/1.jpg","file_name":"cpr.1214020230201-1-1sdvlz6.pdf","download_url":"https://www.academia.edu/attachments/98100174/download_file?st=MTczMjk3OTkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Melatonin_induces_apoptosis_through_biom.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98100174/cpr.1214020230201-1-1sdvlz6-libre.pdf?1675269310=\u0026response-content-disposition=attachment%3B+filename%3DMelatonin_induces_apoptosis_through_biom.pdf\u0026Expires=1732983517\u0026Signature=LcSizO6OnqB4SfuC4J4HQ6QbBwwPyHtfLZFZetGzrYdJW47maiSCYELcL1hZ0Z8LfcNV3Wb3FOPkWzXDYFhDtzrQg3hPtBjbpv~HgAk-uBH0GBB5qdzzILzhMkb-~3t-8e9G6kZszpyBqRhPYNni-twbyLe2MGV~llE~J~egflwQC5Ik1CyZtSfAr4SsWnmmHX7JWGw0BG9PvGjv2EAauGwSwMSYZSPDusrSp5fv8oLKi~QOuS552gmHuKf58W6vL63qRrBbnpjN61yPBGM5cCqp1QkjrlFlXBcrQr8Q2c-e5JVkliUPdoErzQu3Xi2Bldk7U-FFfDMwApN8nGcy2w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Melatonin_induces_apoptosis_through_biomolecular_changes_in_SK_LU_1_human_lung_adenocarcinoma_cells","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[{"id":98100174,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98100174/thumbnails/1.jpg","file_name":"cpr.1214020230201-1-1sdvlz6.pdf","download_url":"https://www.academia.edu/attachments/98100174/download_file?st=MTczMjk3OTkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Melatonin_induces_apoptosis_through_biom.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98100174/cpr.1214020230201-1-1sdvlz6-libre.pdf?1675269310=\u0026response-content-disposition=attachment%3B+filename%3DMelatonin_induces_apoptosis_through_biom.pdf\u0026Expires=1732983517\u0026Signature=LcSizO6OnqB4SfuC4J4HQ6QbBwwPyHtfLZFZetGzrYdJW47maiSCYELcL1hZ0Z8LfcNV3Wb3FOPkWzXDYFhDtzrQg3hPtBjbpv~HgAk-uBH0GBB5qdzzILzhMkb-~3t-8e9G6kZszpyBqRhPYNni-twbyLe2MGV~llE~J~egflwQC5Ik1CyZtSfAr4SsWnmmHX7JWGw0BG9PvGjv2EAauGwSwMSYZSPDusrSp5fv8oLKi~QOuS552gmHuKf58W6vL63qRrBbnpjN61yPBGM5cCqp1QkjrlFlXBcrQr8Q2c-e5JVkliUPdoErzQu3Xi2Bldk7U-FFfDMwApN8nGcy2w__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51570,"name":"Melatonin","url":"https://www.academia.edu/Documents/in/Melatonin"},{"id":219007,"name":"Pi","url":"https://www.academia.edu/Documents/in/Pi"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":1235612,"name":"DAPI","url":"https://www.academia.edu/Documents/in/DAPI"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1727314,"name":"Nucleic Acid","url":"https://www.academia.edu/Documents/in/Nucleic_Acid"},{"id":2256666,"name":"DNA fragmentation","url":"https://www.academia.edu/Documents/in/DNA_fragmentation"},{"id":3101476,"name":"Annexin","url":"https://www.academia.edu/Documents/in/Annexin"}],"urls":[{"id":28593975,"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcpr.12140"}]}, dispatcherData: dispatcherData }); 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The common hepatitis viruses that are transmitted through blood transfusion are hepatitis B and hepatitis C viruses. The objective of this study is to investigate the prevalence of hepatitis B and C virus infections in the first donating blood donor in the YALA province from January 2001 to December 2005 by retrospective analysis of data from laboratory record of the YALA regional hospital. The total number of the first time blood donors was 11,611. Amongst these, hepatitis B virus infected donors were 310 (2.67%) consisting of 262 males (2.78%) and 48 females (2.17%). The prevalence of hepatitis C virus infected donors was 183 (1.58%) with 164 males (1.74%) and 19 females (0.86%). Hepatitis B virus infections were mostly found in age ranging of 36-45 years old (2.92%) where as hepatitis C virus infections were mostly found in 26-35 years of age (2.21%)....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d42f899111e3f1938c791af4735d7ca3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91435998,"asset_id":87140538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91435998/download_file?st=MTczMjk3OTkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140538; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140538]").text(description); $(".js-view-count[data-work-id=87140538]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140538; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140538']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140538, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d42f899111e3f1938c791af4735d7ca3" } } $('.js-work-strip[data-work-id=87140538]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140538,"title":"Prevalence of hepatitis virus infections in the first donating blood donors at the Regional YALA Hospital during 2001-2005","translated_title":"","metadata":{"abstract":"The screening tests for donor blood samples in blood bank are important to prevent the recipients from blood transmitted diseases. 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F. Muell. var. Crustacean" class="work-thumbnail" src="https://attachments.academia-assets.com/91435999/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87140537/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean">Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean</a></div><div class="wp-workCard_item"><span>Walailak Journal of Science and Technology (WJST)</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lindernia crustacea (L.) F. Muell. var. crustacean or “Ya Kap Hoi: YKH” was misunderstood as “Ya ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lindernia crustacea (L.) F. Muell. var. crustacean or “Ya Kap Hoi: YKH” was misunderstood as “Ya Yad Nam Kang” and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC50 concentrations of the YKH ethanolic extrac...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e0854db9ffd9fb85d9e0ba02594da3b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91435999,"asset_id":87140537,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91435999/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140537"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140537"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140537; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140537]").text(description); $(".js-view-count[data-work-id=87140537]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140537; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140537']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140537, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e0854db9ffd9fb85d9e0ba02594da3b8" } } $('.js-work-strip[data-work-id=87140537]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140537,"title":"Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean","translated_title":"","metadata":{"abstract":"Lindernia crustacea (L.) F. Muell. var. crustacean or “Ya Kap Hoi: YKH” was misunderstood as “Ya Yad Nam Kang” and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140536"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87140536/Immunomodulatory_effect_of_melatonin_in_SK_LU_1_human_lung_adenocarcinoma_cells_co_cultured_with_peripheral_blood_mononuclear_cells"><img alt="Research paper thumbnail of Immunomodulatory effect of melatonin in SK-LU-1 human lung adenocarcinoma cells co-cultured with peripheral blood mononuclear cells" class="work-thumbnail" src="https://attachments.academia-assets.com/91436042/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87140536/Immunomodulatory_effect_of_melatonin_in_SK_LU_1_human_lung_adenocarcinoma_cells_co_cultured_with_peripheral_blood_mononuclear_cells">Immunomodulatory effect of melatonin in SK-LU-1 human lung adenocarcinoma cells co-cultured with peripheral blood mononuclear cells</a></div><div class="wp-workCard_item"><span>Cell proliferation</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The anti-cancer potential of melatonin has been examined using a variety of experimental approach...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The anti-cancer potential of melatonin has been examined using a variety of experimental approaches. Melatonin immunomodulatory action was evaluated against the lung cancer cell line SK-LU-1, in co-culture with human peripheral blood mononuclear cells (PBMC). Melatonin was tested on the cell line only after 24 h incubation (direct effect), and on the co-culture system of SK-LU-1 and PBMC to investigate any indirect effect. Apoptotic induction of the cancer cells was assessed using annexin V/PI staining with flow cytometric analysis for membrane alteration. Intracellular superoxide anion (O2 (•-) ) and hydrogen peroxide (H2 O2 ) for intracellular oxidative stress and glutathione (GSH) for intracellular anti-oxidation were measured with specific fluorescence probes. DNA fractions were measured employing propidium iodide (PI) fluorescence staining. High doses of melatonin were directly toxic to SK-LU-1 cells, while PBMC-mediated indirect effect occurred after moderate doses (1 μm). Und...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e1780fc8a564c838f9364c24a26a3823" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91436042,"asset_id":87140536,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91436042/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140536"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140536"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140536; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140536]").text(description); $(".js-view-count[data-work-id=87140536]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140536; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140536']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140536, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e1780fc8a564c838f9364c24a26a3823" } } $('.js-work-strip[data-work-id=87140536]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140536,"title":"Immunomodulatory effect of melatonin in SK-LU-1 human lung adenocarcinoma cells co-cultured with peripheral blood mononuclear cells","translated_title":"","metadata":{"abstract":"The anti-cancer potential of melatonin has been examined using a variety of experimental approaches. Melatonin immunomodulatory action was evaluated against the lung cancer cell line SK-LU-1, in co-culture with human peripheral blood mononuclear cells (PBMC). Melatonin was tested on the cell line only after 24 h incubation (direct effect), and on the co-culture system of SK-LU-1 and PBMC to investigate any indirect effect. Apoptotic induction of the cancer cells was assessed using annexin V/PI staining with flow cytometric analysis for membrane alteration. Intracellular superoxide anion (O2 (•-) ) and hydrogen peroxide (H2 O2 ) for intracellular oxidative stress and glutathione (GSH) for intracellular anti-oxidation were measured with specific fluorescence probes. DNA fractions were measured employing propidium iodide (PI) fluorescence staining. High doses of melatonin were directly toxic to SK-LU-1 cells, while PBMC-mediated indirect effect occurred after moderate doses (1 μm). Und...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Cell proliferation"},"translated_abstract":"The anti-cancer potential of melatonin has been examined using a variety of experimental approaches. Melatonin immunomodulatory action was evaluated against the lung cancer cell line SK-LU-1, in co-culture with human peripheral blood mononuclear cells (PBMC). Melatonin was tested on the cell line only after 24 h incubation (direct effect), and on the co-culture system of SK-LU-1 and PBMC to investigate any indirect effect. Apoptotic induction of the cancer cells was assessed using annexin V/PI staining with flow cytometric analysis for membrane alteration. Intracellular superoxide anion (O2 (•-) ) and hydrogen peroxide (H2 O2 ) for intracellular oxidative stress and glutathione (GSH) for intracellular anti-oxidation were measured with specific fluorescence probes. DNA fractions were measured employing propidium iodide (PI) fluorescence staining. High doses of melatonin were directly toxic to SK-LU-1 cells, while PBMC-mediated indirect effect occurred after moderate doses (1 μm). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140535"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87140535/210_Effect_of_sesamin_sesamolin_and_sesamol_on_P_glycoprotein_mediated_efflux"><img alt="Research paper thumbnail of 210: Effect of sesamin, sesamolin and sesamol on P-glycoprotein mediated efflux" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87140535/210_Effect_of_sesamin_sesamolin_and_sesamol_on_P_glycoprotein_mediated_efflux">210: Effect of sesamin, sesamolin and sesamol on P-glycoprotein mediated efflux</a></div><div class="wp-workCard_item"><span>European Journal of Cancer</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140535"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140535"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140535; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140535]").text(description); $(".js-view-count[data-work-id=87140535]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140535; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140535']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140535, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140534"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87140534/Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection"><img alt="Research paper thumbnail of Abstract 2344: Soluble MICA in cervical cancer is in a deglycosylated form: Implication for soluble MICA detection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87140534/Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection">Abstract 2344: Soluble MICA in cervical cancer is in a deglycosylated form: Implication for soluble MICA detection</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules are expressed as transmembrane proteins. They are ligands recognized by the natural killer cell receptor group (NKG)2D, an activating receptor on NK cells, gamma delta T cells and activated CD8 T cells. Up-regulated MICA expression was reported in many tumors. Shedding of MICA from tumor cells as soluble MICA (sMICA) is a mechanism for immune evasion. MICA proteins could be presented in various sizes from 43 to 75 kDa depending on degree of glycosylation. Eight potential N-glycosylation sites in a MICA molecule were reported. This study aimed to investigate the size of sMICA in sera of cervical cancer patients and women blood donors by western blot technique. Methods: The sMICA*009 plasmid DNA was transfected to COS7 cells for recombinant sMICA protein production in culture supernatant. The recombinant sMICA protein was harvested and validated with mouse monoclonal anti-MICA antibody (WW6B...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140534"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140534"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140534; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140534]").text(description); $(".js-view-count[data-work-id=87140534]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140534; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140534']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140534, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87140534]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140534,"title":"Abstract 2344: Soluble MICA in cervical cancer is in a deglycosylated form: Implication for soluble MICA detection","translated_title":"","metadata":{"abstract":"Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules are expressed as transmembrane proteins. 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The recombinant sMICA protein was harvested and validated with mouse monoclonal anti-MICA antibody (WW6B...","publisher":"American Association for Cancer Research (AACR)","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Cancer Research"},"translated_abstract":"Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules are expressed as transmembrane proteins. They are ligands recognized by the natural killer cell receptor group (NKG)2D, an activating receptor on NK cells, gamma delta T cells and activated CD8 T cells. Up-regulated MICA expression was reported in many tumors. Shedding of MICA from tumor cells as soluble MICA (sMICA) is a mechanism for immune evasion. MICA proteins could be presented in various sizes from 43 to 75 kDa depending on degree of glycosylation. Eight potential N-glycosylation sites in a MICA molecule were reported. This study aimed to investigate the size of sMICA in sera of cervical cancer patients and women blood donors by western blot technique. Methods: The sMICA*009 plasmid DNA was transfected to COS7 cells for recombinant sMICA protein production in culture supernatant. The recombinant sMICA protein was harvested and validated with mouse monoclonal anti-MICA antibody (WW6B...","internal_url":"https://www.academia.edu/87140534/Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection","translated_internal_url":"","created_at":"2022-09-23T05:10:56.722-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"}],"urls":[{"id":24093226,"url":"https://aacrjournals.org/cancerres/article/70/8_Supplement/2344/562727/Abstract-2344-Soluble-MICA-in-cervical-cancer-is"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79506327"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79506327/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells"><img alt="Research paper thumbnail of Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells" class="work-thumbnail" src="https://attachments.academia-assets.com/86198216/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79506327/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells">Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells</a></div><div class="wp-workCard_item"><span>Cell Prolif., 2015, 48, 67–77</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Materials and methods: Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 lM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (DΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Results: Melatonin or cisplatin alone had 50% (IC 50) cytotoxicity at 5 mM or 34 lM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC 50 to 11 and 4 lM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. Conclusion: These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2b6f8723c5ecc3822dff59e51c3fbd75" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86198216,"asset_id":79506327,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86198216/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79506327"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79506327"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79506327; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79506327]").text(description); $(".js-view-count[data-work-id=79506327]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79506327; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79506327']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79506327, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2b6f8723c5ecc3822dff59e51c3fbd75" } } $('.js-work-strip[data-work-id=79506327]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79506327,"title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells","translated_title":"","metadata":{"doi":"10.1111/cpr.12158","abstract":"Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Materials and methods: Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 lM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (DΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Results: Melatonin or cisplatin alone had 50% (IC 50) cytotoxicity at 5 mM or 34 lM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC 50 to 11 and 4 lM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. Conclusion: These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Cell Prolif., 2015, 48, 67–77"},"translated_abstract":"Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Materials and methods: Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 lM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (DΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Results: Melatonin or cisplatin alone had 50% (IC 50) cytotoxicity at 5 mM or 34 lM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC 50 to 11 and 4 lM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. Conclusion: These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","internal_url":"https://www.academia.edu/79506327/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_internal_url":"","created_at":"2022-05-20T03:25:12.032-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":38258531,"work_id":79506327,"tagging_user_id":12754608,"tagged_user_id":181630633,"co_author_invite_id":null,"email":"n***a@kku.ac.th","affiliation":"Khon Kaen University","display_order":1,"name":"Natthida Weerapreeyakul","title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells"},{"id":38258532,"work_id":79506327,"tagging_user_id":12754608,"tagged_user_id":83452784,"co_author_invite_id":null,"email":"p***e@gmail.com","display_order":3,"name":"Preeyaporn Plaimee","title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells"},{"id":38258533,"work_id":79506327,"tagging_user_id":12754608,"tagged_user_id":null,"co_author_invite_id":4350044,"email":"p***a@kku.ac.th","display_order":4,"name":"Nutjaree Pratheepawanit Johns","title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells"}],"downloadable_attachments":[{"id":86198216,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86198216/thumbnails/1.jpg","file_name":"2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN.pdf","download_url":"https://www.academia.edu/attachments/86198216/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Melatonin_potentiates_cisplatin_induced.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86198216/2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN-libre.pdf?1653044302=\u0026response-content-disposition=attachment%3B+filename%3DMelatonin_potentiates_cisplatin_induced.pdf\u0026Expires=1732983518\u0026Signature=L70r-r14aJjgbX8CxFhERiDGZAB38SzBIK3zVoelTbmPfuRefVlwu2H8xupQQ2WyE2Oc8fUgskYwsJJuQjPExmN11Mu4oUWRjTDYv7yuMJotCsuYfE5wfh22H7HUq67w3cv88aKRoKxTBZzmjomxUWWEaLIXDQ0AWuiQiERk3dwiSq0wyQy7gywgyvmdW7iSvoNDltWbhd4O0~kEUZr1Swfj2L6zrg01vE0hui8XDlDqgLNi5Cy9uUz0UQrDWAqm2dqVgf08ZOwfJ5FmYPPAFwhWSVcRi1xxfyQY2o-10nLaV3CShoqJvrUPjyAlVu5iFYrwAf5kBYOxrDAwuGJChw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[{"id":86198216,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86198216/thumbnails/1.jpg","file_name":"2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN.pdf","download_url":"https://www.academia.edu/attachments/86198216/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Melatonin_potentiates_cisplatin_induced.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86198216/2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN-libre.pdf?1653044302=\u0026response-content-disposition=attachment%3B+filename%3DMelatonin_potentiates_cisplatin_induced.pdf\u0026Expires=1732983518\u0026Signature=L70r-r14aJjgbX8CxFhERiDGZAB38SzBIK3zVoelTbmPfuRefVlwu2H8xupQQ2WyE2Oc8fUgskYwsJJuQjPExmN11Mu4oUWRjTDYv7yuMJotCsuYfE5wfh22H7HUq67w3cv88aKRoKxTBZzmjomxUWWEaLIXDQ0AWuiQiERk3dwiSq0wyQy7gywgyvmdW7iSvoNDltWbhd4O0~kEUZr1Swfj2L6zrg01vE0hui8XDlDqgLNi5Cy9uUz0UQrDWAqm2dqVgf08ZOwfJ5FmYPPAFwhWSVcRi1xxfyQY2o-10nLaV3CShoqJvrUPjyAlVu5iFYrwAf5kBYOxrDAwuGJChw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="77651314"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/77651314/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells"><img alt="Research paper thumbnail of Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/77651314/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells">Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells</a></div><div class="wp-workCard_item"><span>Cell Proliferation</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 μM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (ΔΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Melatonin or cisplatin alone had 50% (IC50 ) cytotoxicity at 5 mM or 34 μM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC50 to 11 and 4 μM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="77651314"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="77651314"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 77651314; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=77651314]").text(description); $(".js-view-count[data-work-id=77651314]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 77651314; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='77651314']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 77651314, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=77651314]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":77651314,"title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells","translated_title":"","metadata":{"abstract":"Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 μM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (ΔΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Melatonin or cisplatin alone had 50% (IC50 ) cytotoxicity at 5 mM or 34 μM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC50 to 11 and 4 μM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Cell Proliferation"},"translated_abstract":"Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 μM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (ΔΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Melatonin or cisplatin alone had 50% (IC50 ) cytotoxicity at 5 mM or 34 μM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC50 to 11 and 4 μM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","internal_url":"https://www.academia.edu/77651314/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_internal_url":"","created_at":"2022-04-26T02:45:13.214-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51570,"name":"Melatonin","url":"https://www.academia.edu/Documents/in/Melatonin"},{"id":276781,"name":"Cisplatin","url":"https://www.academia.edu/Documents/in/Cisplatin"},{"id":574882,"name":"Cell cycle checkpoints","url":"https://www.academia.edu/Documents/in/Cell_cycle_checkpoints"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1745478,"name":"Adenocarcinoma","url":"https://www.academia.edu/Documents/in/Adenocarcinoma"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267620"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/69267620/Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults"><img alt="Research paper thumbnail of Effect of ABCB1 3435C>T transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/69267620/Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults">Effect of ABCB1 3435C>T transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults</a></div><div class="wp-workCard_item"><span>Asian Pacific Journal of Tropical Medicine</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with HIV-1. Methods: A single nucleotide polymorphism of ABCB1 3435C&gt;T (rs1045642) in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz treatment. Plasma concentrations of efavirenz were measured by high-performance liquid chromatography 12 hr after administration. The relationship between plasma efavirenz concentrations and ABCB1 3435C&gt;T polymorphisms was analyzed. Results: Logistic regression analysis showed no significant predictors of high plasma efavirenz concentration in relation to age, gender, body weight, CD4 count and plasma HIV-1 RNA, blood biochemical parameters, antiretroviral duration or ABCB1 3435C&gt;T polymorphisms, except for height (OR=0.902, 95% CI: 0.835-0.973) (P&lt;0.05). The minor allele frequency of ABCB1 3435C&gt;T was 0.446. The frequency of the heterozyg...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267620"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267620"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267620; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267620]").text(description); $(".js-view-count[data-work-id=69267620]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267620; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267620']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267620, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=69267620]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267620,"title":"Effect of ABCB1 3435C\u003eT transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults","translated_title":"","metadata":{"abstract":"Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with HIV-1. Methods: A single nucleotide polymorphism of ABCB1 3435C\u0026gt;T (rs1045642) in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz treatment. Plasma concentrations of efavirenz were measured by high-performance liquid chromatography 12 hr after administration. The relationship between plasma efavirenz concentrations and ABCB1 3435C\u0026gt;T polymorphisms was analyzed. Results: Logistic regression analysis showed no significant predictors of high plasma efavirenz concentration in relation to age, gender, body weight, CD4 count and plasma HIV-1 RNA, blood biochemical parameters, antiretroviral duration or ABCB1 3435C\u0026gt;T polymorphisms, except for height (OR=0.902, 95% CI: 0.835-0.973) (P\u0026lt;0.05). The minor allele frequency of ABCB1 3435C\u0026gt;T was 0.446. The frequency of the heterozyg...","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Asian Pacific Journal of Tropical Medicine"},"translated_abstract":"Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with HIV-1. Methods: A single nucleotide polymorphism of ABCB1 3435C\u0026gt;T (rs1045642) in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz treatment. Plasma concentrations of efavirenz were measured by high-performance liquid chromatography 12 hr after administration. The relationship between plasma efavirenz concentrations and ABCB1 3435C\u0026gt;T polymorphisms was analyzed. Results: Logistic regression analysis showed no significant predictors of high plasma efavirenz concentration in relation to age, gender, body weight, CD4 count and plasma HIV-1 RNA, blood biochemical parameters, antiretroviral duration or ABCB1 3435C\u0026gt;T polymorphisms, except for height (OR=0.902, 95% CI: 0.835-0.973) (P\u0026lt;0.05). The minor allele frequency of ABCB1 3435C\u0026gt;T was 0.446. The frequency of the heterozyg...","internal_url":"https://www.academia.edu/69267620/Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults","translated_internal_url":"","created_at":"2022-01-23T10:20:00.826-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267618"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267618/Antioxidant_antimelanogenic_and_skin_protective_effect_of_sesamol"><img alt="Research paper thumbnail of Antioxidant, antimelanogenic, and skin-protective effect of sesamol" class="work-thumbnail" src="https://attachments.academia-assets.com/79428386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267618/Antioxidant_antimelanogenic_and_skin_protective_effect_of_sesamol">Antioxidant, antimelanogenic, and skin-protective effect of sesamol</a></div><div class="wp-workCard_item"><span>Journal of cosmetic science</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sesame contains high nutritional value and important bioactive lignans which are good for health-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH·) radical with an IC50 value &lt; 14.48 µM. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 µM was 189.88 ± 17.56 µM FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 ± 0.2 µM. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 µM and an inhibition of cellular tyrosinase with 23.55 ± 8.25% inhibition at a concentration of 217.2 µM. Sesamol exhibited hi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c95b3d9a59d72abb53a4c4c1cc60f57" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79428386,"asset_id":69267618,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79428386/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267618"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267618"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267618; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267618]").text(description); $(".js-view-count[data-work-id=69267618]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267618; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267618']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267618, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1c95b3d9a59d72abb53a4c4c1cc60f57" } } $('.js-work-strip[data-work-id=69267618]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267618,"title":"Antioxidant, antimelanogenic, and skin-protective effect of sesamol","translated_title":"","metadata":{"abstract":"Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH·) radical with an IC50 value \u0026lt; 14.48 µM. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 µM was 189.88 ± 17.56 µM FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 ± 0.2 µM. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 µM and an inhibition of cellular tyrosinase with 23.55 ± 8.25% inhibition at a concentration of 217.2 µM. Sesamol exhibited hi...","publisher":"Journal of cosmetic science","ai_title_tag":"Sesamol: Antioxidant and Skin-Protective Properties","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of cosmetic science"},"translated_abstract":"Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH·) radical with an IC50 value \u0026lt; 14.48 µM. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 µM was 189.88 ± 17.56 µM FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 ± 0.2 µM. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 µM and an inhibition of cellular tyrosinase with 23.55 ± 8.25% inhibition at a concentration of 217.2 µM. Sesamol exhibited hi...","internal_url":"https://www.academia.edu/69267618/Antioxidant_antimelanogenic_and_skin_protective_effect_of_sesamol","translated_internal_url":"","created_at":"2022-01-23T10:19:59.960-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":79428386,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79428386/thumbnails/1.jpg","file_name":"Antioxidant_antimelanogenic_and_skin-pro20220123-3462-2dc4dn.pdf","download_url":"https://www.academia.edu/attachments/79428386/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Antioxidant_antimelanogenic_and_skin_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79428386/Antioxidant_antimelanogenic_and_skin-pro20220123-3462-2dc4dn.pdf?1642962067=\u0026response-content-disposition=attachment%3B+filename%3DAntioxidant_antimelanogenic_and_skin_pro.pdf\u0026Expires=1732966575\u0026Signature=JEfEiCiKvai-VkJjB4pd3O1INSWeON0edgjuL73nfMd83SZbH~UaW8OugVbVPoTBFblnQuFd1qKuzQSnR7MgL2qAFmt9Q7kIpGeowMC7bBa7K-zaiA6U8xKf~4M60ggF61eDRy1z37-N2BEezQwsAJHkIdyYVVaiX1ExXDciePvUeoDn9N9sZKOxJv-rFnUJ2flvBBysGViYSEqYh7SGbWHMmeR6RKf7cxRVvfcAts6Ici1YfLZYx1U3Pus1UgjxAHfEJY9cQD58ixmAdet3xihzTBYi2PDgJZsnnqAj77BvzE3aSg0W4HOzIRE9QmDgJTDgMPzcPYPPR7sLg3U31Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Antioxidant_antimelanogenic_and_skin_protective_effect_of_sesamol","translated_slug":"","page_count":12,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[{"id":79428386,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79428386/thumbnails/1.jpg","file_name":"Antioxidant_antimelanogenic_and_skin-pro20220123-3462-2dc4dn.pdf","download_url":"https://www.academia.edu/attachments/79428386/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Antioxidant_antimelanogenic_and_skin_pro.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79428386/Antioxidant_antimelanogenic_and_skin-pro20220123-3462-2dc4dn.pdf?1642962067=\u0026response-content-disposition=attachment%3B+filename%3DAntioxidant_antimelanogenic_and_skin_pro.pdf\u0026Expires=1732966575\u0026Signature=JEfEiCiKvai-VkJjB4pd3O1INSWeON0edgjuL73nfMd83SZbH~UaW8OugVbVPoTBFblnQuFd1qKuzQSnR7MgL2qAFmt9Q7kIpGeowMC7bBa7K-zaiA6U8xKf~4M60ggF61eDRy1z37-N2BEezQwsAJHkIdyYVVaiX1ExXDciePvUeoDn9N9sZKOxJv-rFnUJ2flvBBysGViYSEqYh7SGbWHMmeR6RKf7cxRVvfcAts6Ici1YfLZYx1U3Pus1UgjxAHfEJY9cQD58ixmAdet3xihzTBYi2PDgJZsnnqAj77BvzE3aSg0W4HOzIRE9QmDgJTDgMPzcPYPPR7sLg3U31Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51711,"name":"Antioxidants","url":"https://www.academia.edu/Documents/in/Antioxidants"},{"id":57570,"name":"Cercopithecus aethiops","url":"https://www.academia.edu/Documents/in/Cercopithecus_aethiops"},{"id":99023,"name":"Melanoma","url":"https://www.academia.edu/Documents/in/Melanoma"},{"id":347988,"name":"Phenols","url":"https://www.academia.edu/Documents/in/Phenols"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance"},{"id":1116601,"name":"Cosmetic Science","url":"https://www.academia.edu/Documents/in/Cosmetic_Science"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1292080,"name":"Vero cells","url":"https://www.academia.edu/Documents/in/Vero_cells"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267615/Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines"><img alt="Research paper thumbnail of Antiproliferative Effect of Raphanus sativus L. var. caudatus Alef in Human Breast MCF-7 and Human Lung SK-LU1 Adenocarcinoma Cell Lines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267615/Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines">Antiproliferative Effect of Raphanus sativus L. var. caudatus Alef in Human Breast MCF-7 and Human Lung SK-LU1 Adenocarcinoma Cell Lines</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai rat-tail radish—Raphanus sativus L. var. caudatus Alef or RS—the Thai indigenous plant in the same family as broccoli and cabbage. The isothiocyanates (ITCs) have been well-pronounced as the chemopreventive compound found in Brassicaceae plant. Methods: In this study, pod and stem of RS were extracted by dichloromethane via liquid-liquid extraction. Pure ITCs compounds—sulforaphane and sulforaphene—were used as the standards and positive controls. The crude extracts were inve stigated for their antiproliferation assay in the human lung cancer (SK-LU1) and human breast cancer (MCF-7) in comparable with the normal Vero cell line. Results: The results showed that only extract of RS pod showed antiproliferative effect. The SK-LU1 cells were most sensitive to sulforaphane (IC50 = 8.10±0.62 μg/ml), sulforaphene (IC50 = 17.05±0.18 μg/ml) and the RS pods extract (IC50 = 84.22±2.39 μg/ml) than tho...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267615; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267615]").text(description); $(".js-view-count[data-work-id=69267615]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267615; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267615']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267615, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=69267615]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267615,"title":"Antiproliferative Effect of Raphanus sativus L. var. caudatus Alef in Human Breast MCF-7 and Human Lung SK-LU1 Adenocarcinoma Cell Lines","translated_title":"","metadata":{"abstract":"Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai rat-tail radish—Raphanus sativus L. var. caudatus Alef or RS—the Thai indigenous plant in the same family as broccoli and cabbage. The isothiocyanates (ITCs) have been well-pronounced as the chemopreventive compound found in Brassicaceae plant. Methods: In this study, pod and stem of RS were extracted by dichloromethane via liquid-liquid extraction. Pure ITCs compounds—sulforaphane and sulforaphene—were used as the standards and positive controls. The crude extracts were inve stigated for their antiproliferation assay in the human lung cancer (SK-LU1) and human breast cancer (MCF-7) in comparable with the normal Vero cell line. Results: The results showed that only extract of RS pod showed antiproliferative effect. The SK-LU1 cells were most sensitive to sulforaphane (IC50 = 8.10±0.62 μg/ml), sulforaphene (IC50 = 17.05±0.18 μg/ml) and the RS pods extract (IC50 = 84.22±2.39 μg/ml) than tho...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai rat-tail radish—Raphanus sativus L. var. caudatus Alef or RS—the Thai indigenous plant in the same family as broccoli and cabbage. The isothiocyanates (ITCs) have been well-pronounced as the chemopreventive compound found in Brassicaceae plant. Methods: In this study, pod and stem of RS were extracted by dichloromethane via liquid-liquid extraction. Pure ITCs compounds—sulforaphane and sulforaphene—were used as the standards and positive controls. The crude extracts were inve stigated for their antiproliferation assay in the human lung cancer (SK-LU1) and human breast cancer (MCF-7) in comparable with the normal Vero cell line. Results: The results showed that only extract of RS pod showed antiproliferative effect. The SK-LU1 cells were most sensitive to sulforaphane (IC50 = 8.10±0.62 μg/ml), sulforaphene (IC50 = 17.05±0.18 μg/ml) and the RS pods extract (IC50 = 84.22±2.39 μg/ml) than tho...","internal_url":"https://www.academia.edu/69267615/Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines","translated_internal_url":"","created_at":"2022-01-23T10:19:59.258-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267613"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267613/Torquetenovirus_infection_among_northeastern_Thai_blood_donors"><img alt="Research paper thumbnail of Torquetenovirus infection among northeastern Thai blood donors" class="work-thumbnail" src="https://attachments.academia-assets.com/79428349/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267613/Torquetenovirus_infection_among_northeastern_Thai_blood_donors">Torquetenovirus infection among northeastern Thai blood donors</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Semi-nested polymerase chain reaction technique was used to detect Torquetenovirus (TTV) DNA in 2...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Semi-nested polymerase chain reaction technique was used to detect Torquetenovirus (TTV) DNA in 234 healthy blood donors in northeast Thailand. The incidence of TTV was 28% in 101 healthy blood donors negative for HBsAg and anti-HCV antibody, 25% in 71 HBsAg carriers and 29% among 62 with anti-HCV antibody. No association of TTV infection was found with gender, age, and HBV or HCV infection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b66f31d86e84c2e7966b6ddee09f8497" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79428349,"asset_id":69267613,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79428349/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267613"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267613"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267613; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267613]").text(description); $(".js-view-count[data-work-id=69267613]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267613; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267613']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267613, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b66f31d86e84c2e7966b6ddee09f8497" } } $('.js-work-strip[data-work-id=69267613]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267613,"title":"Torquetenovirus infection among northeastern Thai blood donors","translated_title":"","metadata":{"abstract":"Semi-nested polymerase chain reaction technique was used to detect Torquetenovirus (TTV) DNA in 234 healthy blood donors in northeast Thailand. The incidence of TTV was 28% in 101 healthy blood donors negative for HBsAg and anti-HCV antibody, 25% in 71 HBsAg carriers and 29% among 62 with anti-HCV antibody. No association of TTV infection was found with gender, age, and HBV or HCV infection.","publisher":"The Southeast Asian journal of tropical medicine and public health","publication_date":{"day":null,"month":null,"year":2007,"errors":{}}},"translated_abstract":"Semi-nested polymerase chain reaction technique was used to detect Torquetenovirus (TTV) DNA in 234 healthy blood donors in northeast Thailand. The incidence of TTV was 28% in 101 healthy blood donors negative for HBsAg and anti-HCV antibody, 25% in 71 HBsAg carriers and 29% among 62 with anti-HCV antibody. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267606"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/69267606/150_High_selective_cytotoxic_activity_of_sesamol_induced_mitochondrialmediated_apoptosis_pathway_in_lung_adenocarcinoma_cells"><img alt="Research paper thumbnail of 150: High selective cytotoxic activity of sesamol induced mitochondrialmediated apoptosis pathway in lung adenocarcinoma cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/69267606/150_High_selective_cytotoxic_activity_of_sesamol_induced_mitochondrialmediated_apoptosis_pathway_in_lung_adenocarcinoma_cells">150: High selective cytotoxic activity of sesamol induced mitochondrialmediated apoptosis pathway in lung adenocarcinoma cells</a></div><div class="wp-workCard_item"><span>European Journal of Cancer</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267606"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267606"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267606; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267446"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267446/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean_1"><img alt="Research paper thumbnail of Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean †1" class="work-thumbnail" src="https://attachments.academia-assets.com/79428303/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267446/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean_1">Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean †1</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lindernia crustacea (L.) F. Muell. var. crustacean or &quot;Ya Kap Hoi: YKH&quot; was misundersto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lindernia crustacea (L.) F. Muell. var. crustacean or &quot;Ya Kap Hoi: YKH&quot; was misunderstood as &quot;Ya Yad Nam Kang&quot; and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC 50 concentrations of the...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bdf05fb1789241ebc8fcfa91f20ebb58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79428303,"asset_id":69267446,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79428303/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267446"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267446"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267446; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267446]").text(description); $(".js-view-count[data-work-id=69267446]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267446; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267446']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267446, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bdf05fb1789241ebc8fcfa91f20ebb58" } } $('.js-work-strip[data-work-id=69267446]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267446,"title":"Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean †1","translated_title":"","metadata":{"abstract":"Lindernia crustacea (L.) F. Muell. var. crustacean or \u0026quot;Ya Kap Hoi: YKH\u0026quot; was misunderstood as \u0026quot;Ya Yad Nam Kang\u0026quot; and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC 50 concentrations of the..."},"translated_abstract":"Lindernia crustacea (L.) F. Muell. var. crustacean or \u0026quot;Ya Kap Hoi: YKH\u0026quot; was misunderstood as \u0026quot;Ya Yad Nam Kang\u0026quot; and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC 50 concentrations of the...","internal_url":"https://www.academia.edu/69267446/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean_1","translated_internal_url":"","created_at":"2022-01-23T10:17:24.235-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":79428303,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79428303/thumbnails/1.jpg","file_name":"982.pdf","download_url":"https://www.academia.edu/attachments/79428303/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Investigation_of_Anticancer_Activity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79428303/982-libre.pdf?1642965495=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_Anticancer_Activity_of.pdf\u0026Expires=1732966575\u0026Signature=Gr1ZpfxGipEDy18R2x5t9LBlT3yOT8lVMpKRiYD1lLsvSxSyl0vzbhHQwkGmeAO5Kbs19wgsx1AlM-mxEo~BDVaVCu26jd0TSSOGZmrdxmrfwo7JeDK7-QzOfBTx4wrYKZfch9CAJzE4oQBDEVT~np8jMTAyCZ6SHd9-OAiOG~dtHifTjE2uQXyTSmIYAf-2yBUh1sGAx~lguOPb1kJCmmvUaOmgP0Kp1s5kscDwvmNepRx5HI2SNZOeK-Yfw8K9-5SeRJEETH5G0DQzGFZRYNmSPMJZFkUPS8luYSBVQuS4DOUlac4YuAaSZ8o~T0bzOY8QmLM9ZOn~VW6kQOlADg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean_1","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[{"id":79428303,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/79428303/thumbnails/1.jpg","file_name":"982.pdf","download_url":"https://www.academia.edu/attachments/79428303/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Investigation_of_Anticancer_Activity_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/79428303/982-libre.pdf?1642965495=\u0026response-content-disposition=attachment%3B+filename%3DInvestigation_of_Anticancer_Activity_of.pdf\u0026Expires=1732966575\u0026Signature=Gr1ZpfxGipEDy18R2x5t9LBlT3yOT8lVMpKRiYD1lLsvSxSyl0vzbhHQwkGmeAO5Kbs19wgsx1AlM-mxEo~BDVaVCu26jd0TSSOGZmrdxmrfwo7JeDK7-QzOfBTx4wrYKZfch9CAJzE4oQBDEVT~np8jMTAyCZ6SHd9-OAiOG~dtHifTjE2uQXyTSmIYAf-2yBUh1sGAx~lguOPb1kJCmmvUaOmgP0Kp1s5kscDwvmNepRx5HI2SNZOeK-Yfw8K9-5SeRJEETH5G0DQzGFZRYNmSPMJZFkUPS8luYSBVQuS4DOUlac4YuAaSZ8o~T0bzOY8QmLM9ZOn~VW6kQOlADg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"}],"urls":[]}, dispatcherData: dispatcherData }); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "69db8b4fd23dc7d82e5fb395e199f7ff" } } $('.js-work-strip[data-work-id=96110855]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96110855,"title":"Melatonin induces apoptosis through biomolecular changes, in SK-LU-1 human lung adenocarcinoma cells","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Objectives: Anti-cancer effects of melatonin (Nacetyl-5-methoxytryptamine, an indole-amine), have been widely reported, however, little has been known, regarding its mechanism(s) of action in lung cancer. Thus, we investigated its induction of apoptosis through biomolecular changes (lipid, protein and nucleic acid/DNA) in the SK-LU-1 human lung cancer cell line. Materials and methods: We used Fourier transform infrared (FTIR) microspectroscopy, and conventional methods, to confirm changes in lipid (annexin V/PI staining for membrane alteration), protein (caspase-3/7 protein activity) and DNA (DAPI staining for DNA fragmentation). Results: We observed from FTIR data that melatonin increased lipid content and reduced intensity of nucleic acid/DNA, confirmed by annexin V/PI and DAPI respectively. Secondary protein structure at 1656 cm À1 (a-helix) was reduced and peak position of b-sheet structure (1637 cm À1) was shifted to lower frequency. Alteration in apoptotic proteins was demonstrated via caspase-3/7 activity induction. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140538"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87140538/Prevalence_of_hepatitis_virus_infections_in_the_first_donating_blood_donors_at_the_Regional_YALA_Hospital_during_2001_2005"><img alt="Research paper thumbnail of Prevalence of hepatitis virus infections in the first donating blood donors at the Regional YALA Hospital during 2001-2005" class="work-thumbnail" src="https://attachments.academia-assets.com/91435998/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87140538/Prevalence_of_hepatitis_virus_infections_in_the_first_donating_blood_donors_at_the_Regional_YALA_Hospital_during_2001_2005">Prevalence of hepatitis virus infections in the first donating blood donors at the Regional YALA Hospital during 2001-2005</a></div><div class="wp-workCard_item"><span>Journal of medical technology</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The screening tests for donor blood samples in blood bank are important to prevent the recipients...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The screening tests for donor blood samples in blood bank are important to prevent the recipients from blood transmitted diseases. The common hepatitis viruses that are transmitted through blood transfusion are hepatitis B and hepatitis C viruses. The objective of this study is to investigate the prevalence of hepatitis B and C virus infections in the first donating blood donor in the YALA province from January 2001 to December 2005 by retrospective analysis of data from laboratory record of the YALA regional hospital. The total number of the first time blood donors was 11,611. Amongst these, hepatitis B virus infected donors were 310 (2.67%) consisting of 262 males (2.78%) and 48 females (2.17%). The prevalence of hepatitis C virus infected donors was 183 (1.58%) with 164 males (1.74%) and 19 females (0.86%). Hepatitis B virus infections were mostly found in age ranging of 36-45 years old (2.92%) where as hepatitis C virus infections were mostly found in 26-35 years of age (2.21%)....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d42f899111e3f1938c791af4735d7ca3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91435998,"asset_id":87140538,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91435998/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxNyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140538"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140538"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140538; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140538]").text(description); $(".js-view-count[data-work-id=87140538]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140538; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140538']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140538, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d42f899111e3f1938c791af4735d7ca3" } } $('.js-work-strip[data-work-id=87140538]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140538,"title":"Prevalence of hepatitis virus infections in the first donating blood donors at the Regional YALA Hospital during 2001-2005","translated_title":"","metadata":{"abstract":"The screening tests for donor blood samples in blood bank are important to prevent the recipients from blood transmitted diseases. The common hepatitis viruses that are transmitted through blood transfusion are hepatitis B and hepatitis C viruses. The objective of this study is to investigate the prevalence of hepatitis B and C virus infections in the first donating blood donor in the YALA province from January 2001 to December 2005 by retrospective analysis of data from laboratory record of the YALA regional hospital. The total number of the first time blood donors was 11,611. Amongst these, hepatitis B virus infected donors were 310 (2.67%) consisting of 262 males (2.78%) and 48 females (2.17%). The prevalence of hepatitis C virus infected donors was 183 (1.58%) with 164 males (1.74%) and 19 females (0.86%). Hepatitis B virus infections were mostly found in age ranging of 36-45 years old (2.92%) where as hepatitis C virus infections were mostly found in 26-35 years of age (2.21%)....","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Journal of medical technology"},"translated_abstract":"The screening tests for donor blood samples in blood bank are important to prevent the recipients from blood transmitted diseases. The common hepatitis viruses that are transmitted through blood transfusion are hepatitis B and hepatitis C viruses. The objective of this study is to investigate the prevalence of hepatitis B and C virus infections in the first donating blood donor in the YALA province from January 2001 to December 2005 by retrospective analysis of data from laboratory record of the YALA regional hospital. The total number of the first time blood donors was 11,611. Amongst these, hepatitis B virus infected donors were 310 (2.67%) consisting of 262 males (2.78%) and 48 females (2.17%). The prevalence of hepatitis C virus infected donors was 183 (1.58%) with 164 males (1.74%) and 19 females (0.86%). Hepatitis B virus infections were mostly found in age ranging of 36-45 years old (2.92%) where as hepatitis C virus infections were mostly found in 26-35 years of age (2.21%)....","internal_url":"https://www.academia.edu/87140538/Prevalence_of_hepatitis_virus_infections_in_the_first_donating_blood_donors_at_the_Regional_YALA_Hospital_during_2001_2005","translated_internal_url":"","created_at":"2022-09-23T05:10:57.434-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":91435998,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91435998/thumbnails/1.jpg","file_name":"54034.pdf","download_url":"https://www.academia.edu/attachments/91435998/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prevalence_of_hepatitis_virus_infections.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91435998/54034-libre.pdf?1663943242=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_of_hepatitis_virus_infections.pdf\u0026Expires=1732983517\u0026Signature=RaleDBxwLh14O56X5kKHt2B0WFlA3B2jQxPJ3XCyEKM83vxeV51TqFH5fvZQVGXDZqJoDo7Eg8AqNh9qBvlpQ2rjR8J2L4pK3jdsPzLCPPUG36QJL3WpK5kHe2eQdzm9MbW7OdVMakdIenosy~RNMZPKGIrYjZ6KtMIcr~qP5PFWtGTU3WvaWlYsOHGxvcvUs1z88h82eM~8SAsqhTSUtw4VMTdTCRgwLG7Dj7TcSBWFgW33vDmgK4Z6BtWQyt7Ap2IuKzbnKwNqG1tHcNCvdQOF0xFTbfDGc8yavr~3RAZ6~fQjteJRTxSb0toGwUz8R5INSNznm1eDy1ANCTPc~A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Prevalence_of_hepatitis_virus_infections_in_the_first_donating_blood_donors_at_the_Regional_YALA_Hospital_during_2001_2005","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[{"id":91435998,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91435998/thumbnails/1.jpg","file_name":"54034.pdf","download_url":"https://www.academia.edu/attachments/91435998/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxNyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Prevalence_of_hepatitis_virus_infections.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91435998/54034-libre.pdf?1663943242=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_of_hepatitis_virus_infections.pdf\u0026Expires=1732983517\u0026Signature=RaleDBxwLh14O56X5kKHt2B0WFlA3B2jQxPJ3XCyEKM83vxeV51TqFH5fvZQVGXDZqJoDo7Eg8AqNh9qBvlpQ2rjR8J2L4pK3jdsPzLCPPUG36QJL3WpK5kHe2eQdzm9MbW7OdVMakdIenosy~RNMZPKGIrYjZ6KtMIcr~qP5PFWtGTU3WvaWlYsOHGxvcvUs1z88h82eM~8SAsqhTSUtw4VMTdTCRgwLG7Dj7TcSBWFgW33vDmgK4Z6BtWQyt7Ap2IuKzbnKwNqG1tHcNCvdQOF0xFTbfDGc8yavr~3RAZ6~fQjteJRTxSb0toGwUz8R5INSNznm1eDy1ANCTPc~A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":73396,"name":"Medical Technology","url":"https://www.academia.edu/Documents/in/Medical_Technology"}],"urls":[{"id":24093228,"url":"https://he01.tci-thaijo.org/index.php/ams/article/download/66092/54034/"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140537"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87140537/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean"><img alt="Research paper thumbnail of Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean" class="work-thumbnail" src="https://attachments.academia-assets.com/91435999/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87140537/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean">Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean</a></div><div class="wp-workCard_item"><span>Walailak Journal of Science and Technology (WJST)</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lindernia crustacea (L.) F. Muell. var. crustacean or “Ya Kap Hoi: YKH” was misunderstood as “Ya ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lindernia crustacea (L.) F. Muell. var. crustacean or “Ya Kap Hoi: YKH” was misunderstood as “Ya Yad Nam Kang” and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC50 concentrations of the YKH ethanolic extrac...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e0854db9ffd9fb85d9e0ba02594da3b8" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91435999,"asset_id":87140537,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91435999/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140537"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140537"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140537; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140537]").text(description); $(".js-view-count[data-work-id=87140537]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140537; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140537']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140537, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e0854db9ffd9fb85d9e0ba02594da3b8" } } $('.js-work-strip[data-work-id=87140537]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140537,"title":"Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean","translated_title":"","metadata":{"abstract":"Lindernia crustacea (L.) F. Muell. var. crustacean or “Ya Kap Hoi: YKH” was misunderstood as “Ya Yad Nam Kang” and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC50 concentrations of the YKH ethanolic extrac...","publisher":"College of Graduate Studies, Walailak University","publication_date":{"day":null,"month":null,"year":2018,"errors":{}},"publication_name":"Walailak Journal of Science and Technology (WJST)"},"translated_abstract":"Lindernia crustacea (L.) F. Muell. var. crustacean or “Ya Kap Hoi: YKH” was misunderstood as “Ya Yad Nam Kang” and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140536"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87140536/Immunomodulatory_effect_of_melatonin_in_SK_LU_1_human_lung_adenocarcinoma_cells_co_cultured_with_peripheral_blood_mononuclear_cells"><img alt="Research paper thumbnail of Immunomodulatory effect of melatonin in SK-LU-1 human lung adenocarcinoma cells co-cultured with peripheral blood mononuclear cells" class="work-thumbnail" src="https://attachments.academia-assets.com/91436042/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87140536/Immunomodulatory_effect_of_melatonin_in_SK_LU_1_human_lung_adenocarcinoma_cells_co_cultured_with_peripheral_blood_mononuclear_cells">Immunomodulatory effect of melatonin in SK-LU-1 human lung adenocarcinoma cells co-cultured with peripheral blood mononuclear cells</a></div><div class="wp-workCard_item"><span>Cell proliferation</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The anti-cancer potential of melatonin has been examined using a variety of experimental approach...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The anti-cancer potential of melatonin has been examined using a variety of experimental approaches. Melatonin immunomodulatory action was evaluated against the lung cancer cell line SK-LU-1, in co-culture with human peripheral blood mononuclear cells (PBMC). Melatonin was tested on the cell line only after 24 h incubation (direct effect), and on the co-culture system of SK-LU-1 and PBMC to investigate any indirect effect. Apoptotic induction of the cancer cells was assessed using annexin V/PI staining with flow cytometric analysis for membrane alteration. Intracellular superoxide anion (O2 (•-) ) and hydrogen peroxide (H2 O2 ) for intracellular oxidative stress and glutathione (GSH) for intracellular anti-oxidation were measured with specific fluorescence probes. DNA fractions were measured employing propidium iodide (PI) fluorescence staining. High doses of melatonin were directly toxic to SK-LU-1 cells, while PBMC-mediated indirect effect occurred after moderate doses (1 μm). Und...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e1780fc8a564c838f9364c24a26a3823" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91436042,"asset_id":87140536,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91436042/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140536"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140536"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140536; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140536]").text(description); $(".js-view-count[data-work-id=87140536]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140536; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140536']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140536, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e1780fc8a564c838f9364c24a26a3823" } } $('.js-work-strip[data-work-id=87140536]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140536,"title":"Immunomodulatory effect of melatonin in SK-LU-1 human lung adenocarcinoma cells co-cultured with peripheral blood mononuclear cells","translated_title":"","metadata":{"abstract":"The anti-cancer potential of melatonin has been examined using a variety of experimental approaches. Melatonin immunomodulatory action was evaluated against the lung cancer cell line SK-LU-1, in co-culture with human peripheral blood mononuclear cells (PBMC). Melatonin was tested on the cell line only after 24 h incubation (direct effect), and on the co-culture system of SK-LU-1 and PBMC to investigate any indirect effect. Apoptotic induction of the cancer cells was assessed using annexin V/PI staining with flow cytometric analysis for membrane alteration. Intracellular superoxide anion (O2 (•-) ) and hydrogen peroxide (H2 O2 ) for intracellular oxidative stress and glutathione (GSH) for intracellular anti-oxidation were measured with specific fluorescence probes. DNA fractions were measured employing propidium iodide (PI) fluorescence staining. High doses of melatonin were directly toxic to SK-LU-1 cells, while PBMC-mediated indirect effect occurred after moderate doses (1 μm). Und...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Cell proliferation"},"translated_abstract":"The anti-cancer potential of melatonin has been examined using a variety of experimental approaches. Melatonin immunomodulatory action was evaluated against the lung cancer cell line SK-LU-1, in co-culture with human peripheral blood mononuclear cells (PBMC). Melatonin was tested on the cell line only after 24 h incubation (direct effect), and on the co-culture system of SK-LU-1 and PBMC to investigate any indirect effect. Apoptotic induction of the cancer cells was assessed using annexin V/PI staining with flow cytometric analysis for membrane alteration. Intracellular superoxide anion (O2 (•-) ) and hydrogen peroxide (H2 O2 ) for intracellular oxidative stress and glutathione (GSH) for intracellular anti-oxidation were measured with specific fluorescence probes. DNA fractions were measured employing propidium iodide (PI) fluorescence staining. High doses of melatonin were directly toxic to SK-LU-1 cells, while PBMC-mediated indirect effect occurred after moderate doses (1 μm). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140534"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87140534/Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection"><img alt="Research paper thumbnail of Abstract 2344: Soluble MICA in cervical cancer is in a deglycosylated form: Implication for soluble MICA detection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87140534/Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection">Abstract 2344: Soluble MICA in cervical cancer is in a deglycosylated form: Implication for soluble MICA detection</a></div><div class="wp-workCard_item"><span>Cancer Research</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules ar...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules are expressed as transmembrane proteins. They are ligands recognized by the natural killer cell receptor group (NKG)2D, an activating receptor on NK cells, gamma delta T cells and activated CD8 T cells. Up-regulated MICA expression was reported in many tumors. Shedding of MICA from tumor cells as soluble MICA (sMICA) is a mechanism for immune evasion. MICA proteins could be presented in various sizes from 43 to 75 kDa depending on degree of glycosylation. Eight potential N-glycosylation sites in a MICA molecule were reported. This study aimed to investigate the size of sMICA in sera of cervical cancer patients and women blood donors by western blot technique. Methods: The sMICA*009 plasmid DNA was transfected to COS7 cells for recombinant sMICA protein production in culture supernatant. The recombinant sMICA protein was harvested and validated with mouse monoclonal anti-MICA antibody (WW6B...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140534"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140534"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140534; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87140534]").text(description); $(".js-view-count[data-work-id=87140534]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87140534; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87140534']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 87140534, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87140534]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87140534,"title":"Abstract 2344: Soluble MICA in cervical cancer is in a deglycosylated form: Implication for soluble MICA detection","translated_title":"","metadata":{"abstract":"Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules are expressed as transmembrane proteins. They are ligands recognized by the natural killer cell receptor group (NKG)2D, an activating receptor on NK cells, gamma delta T cells and activated CD8 T cells. Up-regulated MICA expression was reported in many tumors. Shedding of MICA from tumor cells as soluble MICA (sMICA) is a mechanism for immune evasion. MICA proteins could be presented in various sizes from 43 to 75 kDa depending on degree of glycosylation. Eight potential N-glycosylation sites in a MICA molecule were reported. This study aimed to investigate the size of sMICA in sera of cervical cancer patients and women blood donors by western blot technique. Methods: The sMICA*009 plasmid DNA was transfected to COS7 cells for recombinant sMICA protein production in culture supernatant. The recombinant sMICA protein was harvested and validated with mouse monoclonal anti-MICA antibody (WW6B...","publisher":"American Association for Cancer Research (AACR)","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Cancer Research"},"translated_abstract":"Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules are expressed as transmembrane proteins. They are ligands recognized by the natural killer cell receptor group (NKG)2D, an activating receptor on NK cells, gamma delta T cells and activated CD8 T cells. Up-regulated MICA expression was reported in many tumors. Shedding of MICA from tumor cells as soluble MICA (sMICA) is a mechanism for immune evasion. MICA proteins could be presented in various sizes from 43 to 75 kDa depending on degree of glycosylation. Eight potential N-glycosylation sites in a MICA molecule were reported. This study aimed to investigate the size of sMICA in sera of cervical cancer patients and women blood donors by western blot technique. Methods: The sMICA*009 plasmid DNA was transfected to COS7 cells for recombinant sMICA protein production in culture supernatant. The recombinant sMICA protein was harvested and validated with mouse monoclonal anti-MICA antibody (WW6B...","internal_url":"https://www.academia.edu/87140534/Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection","translated_internal_url":"","created_at":"2022-09-23T05:10:56.722-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Abstract_2344_Soluble_MICA_in_cervical_cancer_is_in_a_deglycosylated_form_Implication_for_soluble_MICA_detection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer"}],"urls":[{"id":24093226,"url":"https://aacrjournals.org/cancerres/article/70/8_Supplement/2344/562727/Abstract-2344-Soluble-MICA-in-cervical-cancer-is"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87140501"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87140501/Hepatitis_B_viral_infection_non_Treponemal_Test_seropositive_among_Thai_Throng_Dum_etnic_group_Blood_donors"><img alt="Research paper thumbnail of Hepatitis B viral infection, non-Treponemal Test seropositive among Thai Throng-Dum etnic group Blood donors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87140501/Hepatitis_B_viral_infection_non_Treponemal_Test_seropositive_among_Thai_Throng_Dum_etnic_group_Blood_donors">Hepatitis B viral infection, non-Treponemal Test seropositive among Thai Throng-Dum etnic group Blood donors</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87140501"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87140501"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87140501; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79506327"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79506327/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells"><img alt="Research paper thumbnail of Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells" class="work-thumbnail" src="https://attachments.academia-assets.com/86198216/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79506327/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells">Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells</a></div><div class="wp-workCard_item"><span>Cell Prolif., 2015, 48, 67–77</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Materials and methods: Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 lM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (DΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Results: Melatonin or cisplatin alone had 50% (IC 50) cytotoxicity at 5 mM or 34 lM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC 50 to 11 and 4 lM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. Conclusion: These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2b6f8723c5ecc3822dff59e51c3fbd75" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86198216,"asset_id":79506327,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86198216/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79506327"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79506327"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79506327; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79506327]").text(description); $(".js-view-count[data-work-id=79506327]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79506327; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79506327']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79506327, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2b6f8723c5ecc3822dff59e51c3fbd75" } } $('.js-work-strip[data-work-id=79506327]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79506327,"title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells","translated_title":"","metadata":{"doi":"10.1111/cpr.12158","abstract":"Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Materials and methods: Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 lM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (DΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Results: Melatonin or cisplatin alone had 50% (IC 50) cytotoxicity at 5 mM or 34 lM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC 50 to 11 and 4 lM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. Conclusion: These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Cell Prolif., 2015, 48, 67–77"},"translated_abstract":"Objectives: Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Materials and methods: Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 lM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (DΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Results: Melatonin or cisplatin alone had 50% (IC 50) cytotoxicity at 5 mM or 34 lM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC 50 to 11 and 4 lM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. Conclusion: These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","internal_url":"https://www.academia.edu/79506327/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_internal_url":"","created_at":"2022-05-20T03:25:12.032-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":38258531,"work_id":79506327,"tagging_user_id":12754608,"tagged_user_id":181630633,"co_author_invite_id":null,"email":"n***a@kku.ac.th","affiliation":"Khon Kaen University","display_order":1,"name":"Natthida Weerapreeyakul","title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells"},{"id":38258532,"work_id":79506327,"tagging_user_id":12754608,"tagged_user_id":83452784,"co_author_invite_id":null,"email":"p***e@gmail.com","display_order":3,"name":"Preeyaporn Plaimee","title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells"},{"id":38258533,"work_id":79506327,"tagging_user_id":12754608,"tagged_user_id":null,"co_author_invite_id":4350044,"email":"p***a@kku.ac.th","display_order":4,"name":"Nutjaree Pratheepawanit Johns","title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells"}],"downloadable_attachments":[{"id":86198216,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86198216/thumbnails/1.jpg","file_name":"2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN.pdf","download_url":"https://www.academia.edu/attachments/86198216/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Melatonin_potentiates_cisplatin_induced.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86198216/2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN-libre.pdf?1653044302=\u0026response-content-disposition=attachment%3B+filename%3DMelatonin_potentiates_cisplatin_induced.pdf\u0026Expires=1732983518\u0026Signature=L70r-r14aJjgbX8CxFhERiDGZAB38SzBIK3zVoelTbmPfuRefVlwu2H8xupQQ2WyE2Oc8fUgskYwsJJuQjPExmN11Mu4oUWRjTDYv7yuMJotCsuYfE5wfh22H7HUq67w3cv88aKRoKxTBZzmjomxUWWEaLIXDQ0AWuiQiERk3dwiSq0wyQy7gywgyvmdW7iSvoNDltWbhd4O0~kEUZr1Swfj2L6zrg01vE0hui8XDlDqgLNi5Cy9uUz0UQrDWAqm2dqVgf08ZOwfJ5FmYPPAFwhWSVcRi1xxfyQY2o-10nLaV3CShoqJvrUPjyAlVu5iFYrwAf5kBYOxrDAwuGJChw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[{"id":86198216,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86198216/thumbnails/1.jpg","file_name":"2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN.pdf","download_url":"https://www.academia.edu/attachments/86198216/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Melatonin_potentiates_cisplatin_induced.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86198216/2015_CPR_Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells_EN-libre.pdf?1653044302=\u0026response-content-disposition=attachment%3B+filename%3DMelatonin_potentiates_cisplatin_induced.pdf\u0026Expires=1732983518\u0026Signature=L70r-r14aJjgbX8CxFhERiDGZAB38SzBIK3zVoelTbmPfuRefVlwu2H8xupQQ2WyE2Oc8fUgskYwsJJuQjPExmN11Mu4oUWRjTDYv7yuMJotCsuYfE5wfh22H7HUq67w3cv88aKRoKxTBZzmjomxUWWEaLIXDQ0AWuiQiERk3dwiSq0wyQy7gywgyvmdW7iSvoNDltWbhd4O0~kEUZr1Swfj2L6zrg01vE0hui8XDlDqgLNi5Cy9uUz0UQrDWAqm2dqVgf08ZOwfJ5FmYPPAFwhWSVcRi1xxfyQY2o-10nLaV3CShoqJvrUPjyAlVu5iFYrwAf5kBYOxrDAwuGJChw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="77651314"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/77651314/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells"><img alt="Research paper thumbnail of Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/77651314/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells">Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells</a></div><div class="wp-workCard_item"><span>Cell Proliferation</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 μM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (ΔΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Melatonin or cisplatin alone had 50% (IC50 ) cytotoxicity at 5 mM or 34 μM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC50 to 11 and 4 μM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="77651314"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="77651314"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 77651314; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=77651314]").text(description); $(".js-view-count[data-work-id=77651314]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 77651314; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='77651314']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 77651314, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=77651314]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":77651314,"title":"Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells","translated_title":"","metadata":{"abstract":"Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 μM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (ΔΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Melatonin or cisplatin alone had 50% (IC50 ) cytotoxicity at 5 mM or 34 μM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC50 to 11 and 4 μM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","publisher":"Wiley-Blackwell","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Cell Proliferation"},"translated_abstract":"Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer treatment. The study described here has evaluated effects of melatonin on cytotoxicity, apoptosis and cell cycle arrest induced with the chemotherapeutic agent cisplatin, in human lung adenocarcinoma cisplatin-sensitive cell line (SK-LU-1), which previously had only limit data. Cells of the SK-LU-1 line were treated with melatonin alone at 1-5 mM concentration or cisplatin alone 10-200 μM, for 48 h in culture. Cytotoxicity was measured by MTT reduction assay. Apoptosis induction was detected by annexin V/PI staining using flow cytometric analysis and DAPI nuclear staining. Change in mitochondrial membrane potential (ΔΨm) was quantified using DiOC6(3) reagent and activities of caspases-3/7 were also investigated. DNA fractions were measured using propidium iodide (PI) staining. Melatonin or cisplatin alone had 50% (IC50 ) cytotoxicity at 5 mM or 34 μM concentrations respectively. Combination of 1 or 2 mM melatonin and cisplatin significantly augmented cytotoxicity of cisplatin by reducing its IC50 to 11 and 4 μM, respectively. Consistently, combined treatment increased population of apoptotic cells by elevating mitochondrial membrane depolarization, activating caspases-3/7 and inducing cell cycle arrest in the S phase, compared to treatment with cisplatin alone. These data demonstrate that melatonin enhanced cisplatin-induced cytotoxicity and apoptosis in SK-LU-1 lung cancer cells. SK-LU-1 cell population growth inhibition was mediated by cell cycle arrest in the S phase. These findings suggest that melatonin has the potential to be used for NSCLC treatment in combination with a chemotherapeutic agent such as cisplatin.","internal_url":"https://www.academia.edu/77651314/Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_internal_url":"","created_at":"2022-04-26T02:45:13.214-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Melatonin_potentiates_cisplatin_induced_apoptosis_and_cell_cycle_arrest_in_human_lung_adenocarcinoma_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51570,"name":"Melatonin","url":"https://www.academia.edu/Documents/in/Melatonin"},{"id":276781,"name":"Cisplatin","url":"https://www.academia.edu/Documents/in/Cisplatin"},{"id":574882,"name":"Cell cycle checkpoints","url":"https://www.academia.edu/Documents/in/Cell_cycle_checkpoints"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":1745478,"name":"Adenocarcinoma","url":"https://www.academia.edu/Documents/in/Adenocarcinoma"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267620"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/69267620/Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults"><img alt="Research paper thumbnail of Effect of ABCB1 3435C>T transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/69267620/Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults">Effect of ABCB1 3435C>T transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults</a></div><div class="wp-workCard_item"><span>Asian Pacific Journal of Tropical Medicine</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz i...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with HIV-1. Methods: A single nucleotide polymorphism of ABCB1 3435C&gt;T (rs1045642) in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz treatment. Plasma concentrations of efavirenz were measured by high-performance liquid chromatography 12 hr after administration. The relationship between plasma efavirenz concentrations and ABCB1 3435C&gt;T polymorphisms was analyzed. Results: Logistic regression analysis showed no significant predictors of high plasma efavirenz concentration in relation to age, gender, body weight, CD4 count and plasma HIV-1 RNA, blood biochemical parameters, antiretroviral duration or ABCB1 3435C&gt;T polymorphisms, except for height (OR=0.902, 95% CI: 0.835-0.973) (P&lt;0.05). The minor allele frequency of ABCB1 3435C&gt;T was 0.446. The frequency of the heterozyg...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267620"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267620"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267620; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267620]").text(description); $(".js-view-count[data-work-id=69267620]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267620; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267620']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267620, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=69267620]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267620,"title":"Effect of ABCB1 3435C\u003eT transporter gene polymorphism on plasma efavirenz concentration in HIV-1 infected Thai adults","translated_title":"","metadata":{"abstract":"Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with HIV-1. Methods: A single nucleotide polymorphism of ABCB1 3435C\u0026gt;T (rs1045642) in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz treatment. Plasma concentrations of efavirenz were measured by high-performance liquid chromatography 12 hr after administration. The relationship between plasma efavirenz concentrations and ABCB1 3435C\u0026gt;T polymorphisms was analyzed. Results: Logistic regression analysis showed no significant predictors of high plasma efavirenz concentration in relation to age, gender, body weight, CD4 count and plasma HIV-1 RNA, blood biochemical parameters, antiretroviral duration or ABCB1 3435C\u0026gt;T polymorphisms, except for height (OR=0.902, 95% CI: 0.835-0.973) (P\u0026lt;0.05). The minor allele frequency of ABCB1 3435C\u0026gt;T was 0.446. The frequency of the heterozyg...","publication_date":{"day":null,"month":null,"year":2020,"errors":{}},"publication_name":"Asian Pacific Journal of Tropical Medicine"},"translated_abstract":"Objective: To investigate the influence of ABCB1 polymorphisms on the plasma level of efavirenz in Thai adult cases infected with HIV-1. Methods: A single nucleotide polymorphism of ABCB1 3435C\u0026gt;T (rs1045642) in the gene encoding ABCB1 was genotyped using real-time PCR-based alleles in 149 HIV-infected Thai adults receiving efavirenz treatment. Plasma concentrations of efavirenz were measured by high-performance liquid chromatography 12 hr after administration. The relationship between plasma efavirenz concentrations and ABCB1 3435C\u0026gt;T polymorphisms was analyzed. Results: Logistic regression analysis showed no significant predictors of high plasma efavirenz concentration in relation to age, gender, body weight, CD4 count and plasma HIV-1 RNA, blood biochemical parameters, antiretroviral duration or ABCB1 3435C\u0026gt;T polymorphisms, except for height (OR=0.902, 95% CI: 0.835-0.973) (P\u0026lt;0.05). The minor allele frequency of ABCB1 3435C\u0026gt;T was 0.446. The frequency of the heterozyg...","internal_url":"https://www.academia.edu/69267620/Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults","translated_internal_url":"","created_at":"2022-01-23T10:20:00.826-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_ABCB1_3435C_T_transporter_gene_polymorphism_on_plasma_efavirenz_concentration_in_HIV_1_infected_Thai_adults","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267618"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267618/Antioxidant_antimelanogenic_and_skin_protective_effect_of_sesamol"><img alt="Research paper thumbnail of Antioxidant, antimelanogenic, and skin-protective effect of sesamol" class="work-thumbnail" src="https://attachments.academia-assets.com/79428386/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267618/Antioxidant_antimelanogenic_and_skin_protective_effect_of_sesamol">Antioxidant, antimelanogenic, and skin-protective effect of sesamol</a></div><div class="wp-workCard_item"><span>Journal of cosmetic science</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sesame contains high nutritional value and important bioactive lignans which are good for health-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH·) radical with an IC50 value &lt; 14.48 µM. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 µM was 189.88 ± 17.56 µM FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 ± 0.2 µM. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 µM and an inhibition of cellular tyrosinase with 23.55 ± 8.25% inhibition at a concentration of 217.2 µM. Sesamol exhibited hi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c95b3d9a59d72abb53a4c4c1cc60f57" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79428386,"asset_id":69267618,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79428386/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267618"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267618"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267618; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267618]").text(description); $(".js-view-count[data-work-id=69267618]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267618; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267618']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267618, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1c95b3d9a59d72abb53a4c4c1cc60f57" } } $('.js-work-strip[data-work-id=69267618]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267618,"title":"Antioxidant, antimelanogenic, and skin-protective effect of sesamol","translated_title":"","metadata":{"abstract":"Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH·) radical with an IC50 value \u0026lt; 14.48 µM. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 µM was 189.88 ± 17.56 µM FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 ± 0.2 µM. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 µM and an inhibition of cellular tyrosinase with 23.55 ± 8.25% inhibition at a concentration of 217.2 µM. Sesamol exhibited hi...","publisher":"Journal of cosmetic science","ai_title_tag":"Sesamol: Antioxidant and Skin-Protective Properties","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Journal of cosmetic science"},"translated_abstract":"Sesame contains high nutritional value and important bioactive lignans which are good for health-promoting effects including sesamol. Sesamol is found in trace amounts in sesame. The biological action from the trace amounts of sesamol found might indicate its efficacy. This paper presents a systematic study of the antimelanogenic and skin-protective effects (antioxidant) of sesamol and positive compounds. The results showed that sesamol had the most scavenging 2,2-Diphenyl-1-picrylhydrazyl hydrate (DPPH·) radical with an IC50 value \u0026lt; 14.48 µM. The antioxidant power (Ferric reducing antioxidant power value) of sesamol at a concentration of 0.1129 µM was 189.88 ± 17.56 µM FeSO4. Sesamol inhibited lipid peroxidation with an IC50 value of 6.15 ± 0.2 µM. Moreover, sesamol possessed a whitening effect by inhibition of mushroom tyrosinase at an IC50 value of 1.6 µM and an inhibition of cellular tyrosinase with 23.55 ± 8.25% inhibition at a concentration of 217.2 µM. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267615"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267615/Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines"><img alt="Research paper thumbnail of Antiproliferative Effect of Raphanus sativus L. var. caudatus Alef in Human Breast MCF-7 and Human Lung SK-LU1 Adenocarcinoma Cell Lines" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267615/Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines">Antiproliferative Effect of Raphanus sativus L. var. caudatus Alef in Human Breast MCF-7 and Human Lung SK-LU1 Adenocarcinoma Cell Lines</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai r...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai rat-tail radish—Raphanus sativus L. var. caudatus Alef or RS—the Thai indigenous plant in the same family as broccoli and cabbage. The isothiocyanates (ITCs) have been well-pronounced as the chemopreventive compound found in Brassicaceae plant. Methods: In this study, pod and stem of RS were extracted by dichloromethane via liquid-liquid extraction. Pure ITCs compounds—sulforaphane and sulforaphene—were used as the standards and positive controls. The crude extracts were inve stigated for their antiproliferation assay in the human lung cancer (SK-LU1) and human breast cancer (MCF-7) in comparable with the normal Vero cell line. Results: The results showed that only extract of RS pod showed antiproliferative effect. The SK-LU1 cells were most sensitive to sulforaphane (IC50 = 8.10±0.62 μg/ml), sulforaphene (IC50 = 17.05±0.18 μg/ml) and the RS pods extract (IC50 = 84.22±2.39 μg/ml) than tho...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267615"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267615"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267615; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267615]").text(description); $(".js-view-count[data-work-id=69267615]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267615; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267615']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267615, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=69267615]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267615,"title":"Antiproliferative Effect of Raphanus sativus L. var. caudatus Alef in Human Breast MCF-7 and Human Lung SK-LU1 Adenocarcinoma Cell Lines","translated_title":"","metadata":{"abstract":"Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai rat-tail radish—Raphanus sativus L. var. caudatus Alef or RS—the Thai indigenous plant in the same family as broccoli and cabbage. The isothiocyanates (ITCs) have been well-pronounced as the chemopreventive compound found in Brassicaceae plant. Methods: In this study, pod and stem of RS were extracted by dichloromethane via liquid-liquid extraction. Pure ITCs compounds—sulforaphane and sulforaphene—were used as the standards and positive controls. The crude extracts were inve stigated for their antiproliferation assay in the human lung cancer (SK-LU1) and human breast cancer (MCF-7) in comparable with the normal Vero cell line. Results: The results showed that only extract of RS pod showed antiproliferative effect. The SK-LU1 cells were most sensitive to sulforaphane (IC50 = 8.10±0.62 μg/ml), sulforaphene (IC50 = 17.05±0.18 μg/ml) and the RS pods extract (IC50 = 84.22±2.39 μg/ml) than tho...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Introduction: This study was aimed to investigate the in vitro antiproliferative effect of Thai rat-tail radish—Raphanus sativus L. var. caudatus Alef or RS—the Thai indigenous plant in the same family as broccoli and cabbage. The isothiocyanates (ITCs) have been well-pronounced as the chemopreventive compound found in Brassicaceae plant. Methods: In this study, pod and stem of RS were extracted by dichloromethane via liquid-liquid extraction. Pure ITCs compounds—sulforaphane and sulforaphene—were used as the standards and positive controls. The crude extracts were inve stigated for their antiproliferation assay in the human lung cancer (SK-LU1) and human breast cancer (MCF-7) in comparable with the normal Vero cell line. Results: The results showed that only extract of RS pod showed antiproliferative effect. The SK-LU1 cells were most sensitive to sulforaphane (IC50 = 8.10±0.62 μg/ml), sulforaphene (IC50 = 17.05±0.18 μg/ml) and the RS pods extract (IC50 = 84.22±2.39 μg/ml) than tho...","internal_url":"https://www.academia.edu/69267615/Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines","translated_internal_url":"","created_at":"2022-01-23T10:19:59.258-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":12754608,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antiproliferative_Effect_of_Raphanus_sativus_L_var_caudatus_Alef_in_Human_Breast_MCF_7_and_Human_Lung_SK_LU1_Adenocarcinoma_Cell_Lines","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":12754608,"first_name":"Sahapat","middle_initials":null,"last_name":"Barusrux","page_name":"SahapatBarusrux","domain_name":"independent","created_at":"2014-06-08T12:46:32.086-07:00","display_name":"Sahapat Barusrux","url":"https://independent.academia.edu/SahapatBarusrux"},"attachments":[],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267613"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267613/Torquetenovirus_infection_among_northeastern_Thai_blood_donors"><img alt="Research paper thumbnail of Torquetenovirus infection among northeastern Thai blood donors" class="work-thumbnail" src="https://attachments.academia-assets.com/79428349/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267613/Torquetenovirus_infection_among_northeastern_Thai_blood_donors">Torquetenovirus infection among northeastern Thai blood donors</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Semi-nested polymerase chain reaction technique was used to detect Torquetenovirus (TTV) DNA in 2...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Semi-nested polymerase chain reaction technique was used to detect Torquetenovirus (TTV) DNA in 234 healthy blood donors in northeast Thailand. The incidence of TTV was 28% in 101 healthy blood donors negative for HBsAg and anti-HCV antibody, 25% in 71 HBsAg carriers and 29% among 62 with anti-HCV antibody. No association of TTV infection was found with gender, age, and HBV or HCV infection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b66f31d86e84c2e7966b6ddee09f8497" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79428349,"asset_id":69267613,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79428349/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267613"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267613"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267613; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267613]").text(description); $(".js-view-count[data-work-id=69267613]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267613; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267613']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267613, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b66f31d86e84c2e7966b6ddee09f8497" } } $('.js-work-strip[data-work-id=69267613]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267613,"title":"Torquetenovirus infection among northeastern Thai blood donors","translated_title":"","metadata":{"abstract":"Semi-nested polymerase chain reaction technique was used to detect Torquetenovirus (TTV) DNA in 234 healthy blood donors in northeast Thailand. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267606"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/69267606/150_High_selective_cytotoxic_activity_of_sesamol_induced_mitochondrialmediated_apoptosis_pathway_in_lung_adenocarcinoma_cells"><img alt="Research paper thumbnail of 150: High selective cytotoxic activity of sesamol induced mitochondrialmediated apoptosis pathway in lung adenocarcinoma cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/69267606/150_High_selective_cytotoxic_activity_of_sesamol_induced_mitochondrialmediated_apoptosis_pathway_in_lung_adenocarcinoma_cells">150: High selective cytotoxic activity of sesamol induced mitochondrialmediated apoptosis pathway in lung adenocarcinoma cells</a></div><div class="wp-workCard_item"><span>European Journal of Cancer</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267606"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267606"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267606; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="69267446"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/69267446/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean_1"><img alt="Research paper thumbnail of Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean †1" class="work-thumbnail" src="https://attachments.academia-assets.com/79428303/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/69267446/Investigation_of_Anticancer_Activity_of_Lindernia_crustacea_L_F_Muell_var_Crustacean_1">Investigation of Anticancer Activity of Lindernia crustacea (L.) F. Muell. var. Crustacean †1</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Lindernia crustacea (L.) F. Muell. var. crustacean or &quot;Ya Kap Hoi: YKH&quot; was misundersto...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Lindernia crustacea (L.) F. Muell. var. crustacean or &quot;Ya Kap Hoi: YKH&quot; was misunderstood as &quot;Ya Yad Nam Kang&quot; and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. The YKH aqueous extract was inactive against all cancer cells tested. Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC 50 concentrations of the...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bdf05fb1789241ebc8fcfa91f20ebb58" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":79428303,"asset_id":69267446,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/79428303/download_file?st=MTczMjk3OTkxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="69267446"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="69267446"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 69267446; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=69267446]").text(description); $(".js-view-count[data-work-id=69267446]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 69267446; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='69267446']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 69267446, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bdf05fb1789241ebc8fcfa91f20ebb58" } } $('.js-work-strip[data-work-id=69267446]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":69267446,"title":"Investigation of Anticancer Activity of Lindernia crustacea (L.) 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Interestingly, YKH ethanolic extract caused cancer cell death in HCT116 colon cancer, HepG2 liver cancer, and Jurkat leukemic cancer cell lines in the concentration dependent manner. The following IC 50 concentrations of the..."},"translated_abstract":"Lindernia crustacea (L.) F. Muell. var. crustacean or \u0026quot;Ya Kap Hoi: YKH\u0026quot; was misunderstood as \u0026quot;Ya Yad Nam Kang\u0026quot; and cancer curative. This study aimed to investigate anticancer activity by the analysis of chemical constituent in extracts and in vitro screening of biological activities of the extract in several aspects such as cancer cell lines cytotoxic activity, immune cell proliferating activity, reducing power activity, alkylation activity. The HPLC analysis showed the absence of plumbagin peak observed in the HPLC chromatograms of both YKH aqueous and YKH ethanolic extracts. The YKH ethanolic extract yielded more chemical constituents than that of the YKH aqueous extract. 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