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Proteomics | SPT Labtech
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class="srch-inpt" placeholder="Search">--> </div> </div> </div> </div> </header> <!--Header--></div> <div class="container-fluid m-0 p-0"> <div class="row-fluid-wrapper"> <div class="row-fluid"> <div class="span12 widget-span widget-type-cell " style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-1 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-2 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1629798268172" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="application-banner image" style="background-image: url('https://www.sptlabtech.com/hubfs/Proteomics%20Protein%20Banner%20.png')"> <div class="overlay"> <div class="grey-overlay"> <div class="container"> <div class="breadcrumb-container"> <ol class="breadcrumb custom-breadcrumb"> <li class="breadcrumb-item" data="2"><a href="/">Home</a></li> <li class="breadcrumb-item"> <a href="/drug-discovery"> Application </a> </li> <li class="breadcrumb-item"> Proteomics </li> </ol> </div> </div> <div class="container"> <div class="flex"> <div class="application-bnr-text medium"> <div class="text-block"> <h1 class="title-symbol">Proteomics</h1> <div id="hs_cos_wrapper_widget_1629798268172_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="banner_content.description"><p><span>The analysis of all proteins produced by an organism allows researchers to study their role on a functional level. This can be done for various reasons, such as screening for markers of disease, examining the role of post-translational modifications, investigating protein-protein interactions, and monitoring dynamic changes in protein expression over time</span></p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-3 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module widget_1625497891256-hidden" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <span id="hs_cos_wrapper_widget_1625497891256" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><!-- custom widget definition not found (portalId: null, path: null, moduleId: null) --></span> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-4 main_area-row-2-max-width-section-centering main_area-row-2-padding main_area-row-2-margin dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708428468592" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1708428468592_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p>Proteomics plays a vital role in understanding disease mechanisms and advancing <a href="https://www.sptlabtech.com/applications/drug-discovery">drug discovery</a> by providing detailed insights into protein function, post-translational modifications and protein-protein interactions. Its ability to identify disease biomarkers, elucidate pathogenic processes, validate drug targets and personalize treatment regimens makes it an indispensable tool in the quest for more effective and safer therapies.</p> <p>Proteins are the primary targets for the majority of drugs, however, comprehensive, system-wide approaches to monitor protein activity and function are still not fully leveraged in <a href="https://www.sptlabtech.com/applications/drug-discovery">drug discovery</a> and clinical research.</p></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430725766" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><!--CTA to Download And Book a Demo Module--> <div class="download-and-book-block" id="download-and-book-block"> <div class="container bullet-list-points"> <div class="cta-download-block"> <div class="tab-content"> <div class="tab-pane in active"> <div class="product-detail-block"> <div class="product-img"> <img src="https://www.sptlabtech.com/hubfs/Reusable-Assets/Protein_ANXA5_PDB_1a8a.png" alt="Protein_ANXA5_PDB_1a8a" loading="lazy" style="max-width: 100%; height: auto;"> </div> <div class="product-info"> <h2>Proteomics: Revolutionizing Drug Discovery and Protein Research</h2> <h2 id="singlecellingenomicsexplained" style="font-size: 48px;"></h2> <p>The analysis of all proteins produced by an organism allows researchers to study their role on a functional level. This can be done for various reasons, such as screening for markers of disease, examining the role of post-translational modifications, investigating protein-protein interactions, and monitoring dynamic changes in protein expression over time. Often used in conjunction with other functional genomics approaches, proteomics plays a crucial role in understanding disease mechanisms and the validation of targets. Our proven miniaturization technology bolsters high-throughput protein biomarker discovery with the <a href="/proven-miniaturization-technology-to-bolster-high-throughput-protein-biomarker-discovery" rel="noopener">Olink Explore platform.</a></p> </div> </div> </div> </div> </div> </div> </div> <!--CTA to Download And Book a Demo Module--></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708430628119" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1708430628119_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><div data-message-author-role="assistant" data-message-id="8ccf7adb-cad4-4ec0-a35b-1e5b72a8dabf"><br> <h3><strong>Recent Innovations in Proteomics</strong></h3> <p>Recent innovations in biochemical methodologies and advancements in instrumentation have significantly advanced proteomics, moving beyond traditional techniques like immunohistochemistry (IHC) staining, western blotting, and enzyme-linked immunosorbent assay (ELISA). Modern approaches now include:</p> <ul> <li>mass spectrometry (MS)-based methods, in which the proteomic content of the cell is digested and analyzed,</li> <li>antibody- and aptamer-based methods that target predefined proteins,</li> <li>imaging-based methods capable of detecting and providing the spatial context of proteins,</li> <li>single-molecule sequencing methods, which offer unprecedented detail at the individual protein level.</li> </ul> </div></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1708428856139" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="block"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/04%20-%20Structural%20Biology/Protein-techniques-hero---crystals.jpg" data-speed="-1.5" class="img-parallax"> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-9 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1710265006637" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1710265006637_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p> </p> <h3><strong>Challenges in Protein Sample Preparation and Analysis</strong></h3> <p>While proteomics brings us closer to understanding the phenotype than genomics or transcriptomics alone, it has yet to achieve the same level of throughput as RNA and DNA sequencing. It is largely due to intrinsic challenges in protein sample preparation and analysis. The human proteome, estimated to consist of around 20,000 to 25,000 protein-coding genes, is further diversified by alternative splicing and post-translational modifications, resulting in hundreds of thousands of protein variants.</p> <p>Unlike nucleic acids, proteins cannot be amplified through techniques like PCR, so proteomic analyses must work directly with the native content, encompassing both low- and high-abundance proteins, which limits method sensitivity.</p> <p>Manual handling in protein sample preparation is a complex and labor-intensive process that demands precision, skill, and careful attention to detail. From extraction and quantification to fractionation and quality control, each step must be performed meticulously to ensure that the obtained results are reproducible and accurately reflect the protein content of the sample.</p> <p>Finally, proteomics typically incurs higher costs per sample compared to the more standardized and scalable processes in genomics, limiting its adoption.</p> <p> </p></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1709894955852" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="block"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/02%20-%20Drug%20Discovery/3d-illustration-protein-or-enzyme.jpg" data-speed="-1.5" class="img-parallax"> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-11 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1710265132569" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1710265132569_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p style="font-size: 48px;"> </p> <h3><strong>Driving the Proteomics Field Forward</strong></h3> <p>Despite these hurdles, ongoing innovations are driving the field forward. Advances in liquid handling automation, analytical instrumentation and the development of sophisticated chemistries are progressively enhancing the throughput, sensitivity, and reliability of proteomics studies.</p> <p>Affinity-based proteomic technologies are receiving increasing attention, particularly in plasma proteomics. The proximity extension assay (PEA) developed by Olink Proteomics is prime examples, using pairs of oligonucleotide-labeled antibodies that bind to adjacent epitopes on target proteins. The proximity of these labels allows for DNA amplification, which is then quantified to determine protein levels. PEA’s remarkable sensitivity enables the detection of low-abundance proteins that might be missed by other techniques. This enables the simultaneous analysis of thousands of proteins from a minute amount of sample, making large-scale studies more feasible. Our proven <a href="https://www.sptlabtech.com/proven-miniaturization-technology-to-bolster-high-throughput-protein-biomarker-discovery">miniaturization technology</a> bolsters high-throughput protein biomarker discovery and population-scale proteogenomics with the Olink Explore platform (<strong>ref 1-2</strong>).</p> <p>Over the past decade, Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) MS has achieved laser scanning speeds of under one second per sample, dramatically reducing acquisition times. MALDI-TOF MS requires very small sample volumes, facilitating assay miniaturization and cost reduction. When combined with automated low-volume liquid handling systems, such as <a href="https://www.sptlabtech.com/products/mosquito/mosquito-lv">mosquito LV</a>, these features make MALDI-TOF MS assays particularly well-suited for robust high-throughput screening (HTS) (<strong>ref 3-4</strong>).</p> <p>Cryo-electron microscopy (<a href="https://www.sptlabtech.com/applications/structural-biology/cryo-em">cryo-EM</a>) has also ushered in a new era of scientific discovery, offering increasingly higher-resolution structural information. Advances in both hardware and software for both sample preparation and analysis have now opened up the technique to more widespread adoption in basic research and drug discovery (<strong>ref 5-6</strong>).</p> <h3><strong>Related products</strong></h3> <p>Our suite of automated liquid handling solutions, mosquito, firefly, dragonfly and chameleon, enhances the reliability and efficiency of proteomics research:</p></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-12 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1628177031915" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="product-card-module anchor-point" id="product-card-module"> <div class="container bullet-list-points"> <div class="text-module bullet-list-points"> <h2></h2> </div> <div class="p-card-module-inr"> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3><strong>firefly<sup>®</sup></strong></h3> <p>Innovative all-in-one liquid handling brings together multiple technologies within a single compact design for more efficient library and sample preparation. Underpinned by powerful, intuitive software, firefly unlocks the potential of automation for all to accelerate single-cell research.</p> <a class="btn" href="https://www.sptlabtech.com/products/firefly"> Explore firefly </a> </div> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=450&height=700&name=firefly-right.png" alt="firefly-right" loading="lazy" width="450" height="700" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=225&height=350&name=firefly-right.png 225w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=450&height=700&name=firefly-right.png 450w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=675&height=1050&name=firefly-right.png 675w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=900&height=1400&name=firefly-right.png 900w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=1125&height=1750&name=firefly-right.png 1125w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/03%20-%20Genomics/02%20-%20NGS/firefly-right.png?width=1350&height=2100&name=firefly-right.png 1350w" sizes="(max-width: 450px) 100vw, 450px"> </div> </div> <div class="product-card d-flex align-items-center"> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=451&height=650&name=dragonfly-product-dfdiscovery---text-block-1.png" alt="dragonfly-product-dfdiscovery---text-block-1" loading="lazy" width="451" height="650" srcset="https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=226&height=325&name=dragonfly-product-dfdiscovery---text-block-1.png 226w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=451&height=650&name=dragonfly-product-dfdiscovery---text-block-1.png 451w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=677&height=975&name=dragonfly-product-dfdiscovery---text-block-1.png 677w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=902&height=1300&name=dragonfly-product-dfdiscovery---text-block-1.png 902w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=1128&height=1625&name=dragonfly-product-dfdiscovery---text-block-1.png 1128w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/02%20-%20dragonfly/01%20-%20dragonfly%20Discovery/dragonfly-product-dfdiscovery---text-block-1.png?width=1353&height=1950&name=dragonfly-product-dfdiscovery---text-block-1.png 1353w" sizes="(max-width: 451px) 100vw, 451px"> </div> <div class="product-card-text pad-l75"> <h3>dragonfly<sup>®</sup> discovery</h3> <p>dragonfly discovery delivers fast and reliable non-contact dispensing for all liquid types thanks to its positive displacement technology. Highly accurate low volume dispensing and ultra-low dead volumes allow researchers to minimize reagent costs, save time and standardize protocols.</p> <a class="btn" href="https://www.sptlabtech.com/products/dragonfly/dragonfly-discovery"> Explore dragonfly discovery </a> </div> </div> <div class="product-card left-card d-flex align-items-center"> <div class="product-card-text pad-r75"> <h3><strong>mosquito<sup>®</sup> LV Genomics</strong></h3> <p>mosquito's ability to handle nanoliter volumes with precision using true positive displacement technology drives down the high costs of single-cell workflows. Harnessing the power of miniaturization enables researchers to drastically improve productivity and reduce cost per sample.</p> <a class="btn" href="https://www.sptlabtech.com/products/mosquito#genomics"> Explore mosquito genomics </a> </div> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/01%20-%20mosquito/mosquito-product-category---product-LV.png?width=450&height=700&name=mosquito-product-category---product-LV.png" alt="mosquito-product-category---product-LV" loading="lazy" width="450" height="700" srcset="https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/01%20-%20mosquito/mosquito-product-category---product-LV.png?width=225&height=350&name=mosquito-product-category---product-LV.png 225w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/01%20-%20mosquito/mosquito-product-category---product-LV.png?width=450&height=700&name=mosquito-product-category---product-LV.png 450w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/01%20-%20mosquito/mosquito-product-category---product-LV.png?width=675&height=1050&name=mosquito-product-category---product-LV.png 675w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/01%20-%20mosquito/mosquito-product-category---product-LV.png?width=900&height=1400&name=mosquito-product-category---product-LV.png 900w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/01%20-%20mosquito/mosquito-product-category---product-LV.png?width=1125&height=1750&name=mosquito-product-category---product-LV.png 1125w, https://www.sptlabtech.com/hs-fs/hubfs/Website/06%20-%20Products/01%20-%20mosquito/mosquito-product-category---product-LV.png?width=1350&height=2100&name=mosquito-product-category---product-LV.png 1350w" sizes="(max-width: 450px) 100vw, 450px"> </div> </div> <div class="product-card d-flex align-items-center"> <div class="product-card-img"> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/01%20-%20Home/home-products-listing-chameleon.png?width=400&height=635&name=home-products-listing-chameleon.png" alt="home-products-listing-chameleon" loading="lazy" width="400" height="635" srcset="https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/01%20-%20Home/home-products-listing-chameleon.png?width=200&height=318&name=home-products-listing-chameleon.png 200w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/01%20-%20Home/home-products-listing-chameleon.png?width=400&height=635&name=home-products-listing-chameleon.png 400w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/01%20-%20Home/home-products-listing-chameleon.png?width=600&height=953&name=home-products-listing-chameleon.png 600w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/01%20-%20Home/home-products-listing-chameleon.png?width=800&height=1270&name=home-products-listing-chameleon.png 800w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/01%20-%20Home/home-products-listing-chameleon.png?width=1000&height=1588&name=home-products-listing-chameleon.png 1000w, https://www.sptlabtech.com/hs-fs/hubfs/SPT%20Labtech%20Website/01%20-%20Home/home-products-listing-chameleon.png?width=1200&height=1905&name=home-products-listing-chameleon.png 1200w" sizes="(max-width: 400px) 100vw, 400px"> </div> <div class="product-card-text pad-l75"> <h3><strong>chameleon<sup>®</sup></strong></h3> <p><span>chameleon delivers optimized grid vitrification for cryo-EM by combining next-generation automation, blotless grid technology, and high speed plunging. Thinking beyond existing sample preparation workflows enables routine high resolution structural studies.</span></p> <a class="btn" href="https://www.sptlabtech.com/products/chameleon"> Explore chameleon </a> </div> </div> </div> </div> </div></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <span id="hs_cos_wrapper_main_area-module-7" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><!-- custom widget definition not found (portalId: null, path: null, moduleId: null) --></span> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-15 dnd-section main_area-row-5-padding main_area-row-5-max-width-section-centering"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-16 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_1710348640448" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_module_1710348640448_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><h3>Key Resources</h3></span></div> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> </div><!--end widget-span --> </div><!--end row--> </div><!--end row-wrapper --> <div class="row-fluid-wrapper row-depth-1 row-number-17 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-18 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1710237004996" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <section class="vertical-tabs-section"> <div class="container"> <div class="how_work_flight"> <div class="vert-tab"> <div class="recr-content active" data-index="1"> <h3><div id="hs_cos_wrapper_widget_1710237004996_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="collapsed_card_title">On-demand webinar ➤➤➤</div></h3> <div class="work_items_content"> <div class="vert_tab_image_wrrapeer"> <div class="vert-tab-content"> <h2>01.</h2> <h4>Supercharge your Olink workflow with the right liquid handling tools</h4> <p></p><p><span>In this webinar, discover how to maximize volumetric precision in Olink proteomic technology workflows for improved accuracy and reliability with multi-omic pipelines for full suite service providers.</span></p> <p style="text-align: center;"><a href="/resources/webinar-supercharge-your-olink-workflow-with-the-right-liquid-handling-tools" rel="noopener">Watch Now</a></p><p></p> </div> <img src="https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=400&height=200&name=Olink%20small%20(1).png" alt="Olink small (1)" loading="lazy" width="400" height="200" style="max-width: 100%; height: auto;" srcset="https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=200&height=100&name=Olink%20small%20(1).png 200w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=400&height=200&name=Olink%20small%20(1).png 400w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=600&height=300&name=Olink%20small%20(1).png 600w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=800&height=400&name=Olink%20small%20(1).png 800w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=1000&height=500&name=Olink%20small%20(1).png 1000w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=1200&height=600&name=Olink%20small%20(1).png 1200w" sizes="(max-width: 400px) 100vw, 400px"> </div> </div> </div> <div class="recr-content " data-index="2"> <h3><div id="hs_cos_wrapper_widget_1710237004996_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="collapsed_card_title">On-demand webinar ➤➤➤</div></h3> <div class="work_items_content"> <div class="vert_tab_image_wrrapeer"> <div class="vert-tab-content"> <h2>02.</h2> <h4>Sensitive high-throughput plasma proteomics</h4> <p></p><p><span>Identifying early markers of transitions between human health and disease is a key objective of systems medicine. The strategy involves collecting diverse longitudinal data for each individual, before and after symptoms manifest.</span></p> <p style="text-align: center;"><a href="/resources/webinar-sensitive-high-throughput-plasma-proteomics-register" rel="noopener">Watch Now</a></p><p></p> </div> <img src="https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=400&height=200&name=Olink%20small%20(1).png" alt="Olink small (1)" loading="lazy" width="400" height="200" style="max-width: 100%; height: auto;" srcset="https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=200&height=100&name=Olink%20small%20(1).png 200w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=400&height=200&name=Olink%20small%20(1).png 400w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=600&height=300&name=Olink%20small%20(1).png 600w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=800&height=400&name=Olink%20small%20(1).png 800w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=1000&height=500&name=Olink%20small%20(1).png 1000w, https://www.sptlabtech.com/hs-fs/hubfs/Olink%20small%20(1).png?width=1200&height=600&name=Olink%20small%20(1).png 1200w" sizes="(max-width: 400px) 100vw, 400px"> </div> </div> </div> <div class="recr-content " data-index="3"> <h3><div id="hs_cos_wrapper_widget_1710237004996_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_text" data-hs-cos-field="collapsed_card_title">On-demand webinar ➤➤➤</div></h3> <div class="work_items_content"> <div class="vert_tab_image_wrrapeer"> <div class="vert-tab-content"> <h2>03.</h2> <h4>Making transfers of crystallisation screens more consistent, reliable and reproducible</h4> <p></p><p><span>In this webinar, you will get a practical walk-through of how to make consistent transfers from a deep well block to a crystal screening plate using an automated pipetting system and examine best practice setting up sitting-drop vapour diffusion crystallisation.</span></p> <p style="text-align: center;"><a href="/resources/webinar-making-transfers-of-crystallisation-screens-more-consistent-reliable-and-reproducible" rel="noopener">Watch Now</a></p><p></p> </div> <img src="https://www.sptlabtech.com/hs-fs/hubfs/SPT_Labtech_Cube_RGB(500x500px)%20(1).jpg?width=100&height=100&name=SPT_Labtech_Cube_RGB(500x500px)%20(1).jpg" alt="SPT_Labtech_Cube_RGB(500x500px) (1)" loading="lazy" width="100" height="100" style="max-width: 100%; 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Large-scale plasma proteomics comparisons through genetics and disease associations Nature. 2023; 622 (7982): 348-358. <a href="https://doi.org/10.1038/s41586-023-06563-x">https://doi.org/10.1038/s41586-023-06563-x</a></li> <li>Åkesson J, Hojjati S, Hellberg S, et al. Proteomics reveal biomarkers for diagnosis, disease activity and long-term disability outcomes in multiple sclerosis. Nat Commun. 2023; 14 (1): 6903. <a href="https://doi.org/10.1038/s41467-023-42682-9">https://doi.org/10.1038/s41467-023-42682-9</a></li> <li>Haslam C, Hellicar J, Dunn A, et al. The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond. J Biomol Screen. 2016; 21 (2): 176-186. <a href="https://doi.org/10.1177/1087057115608605">https://doi.org/10.1177/1087057115608605</a></li> <li>Müller L, Burton AK, Tayler CL, et al. A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1. SLAS Discov. 2023; 28 (1): 3-11. <a href="https://doi.org/10.1016/j.slasd.2022.11.002">https://doi.org/10.1016/j.slasd.2022.11.002</a></li> <li>Liang WG, Wijaya J, Wei H, et al. Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun. 2022; 13 (1): 1833. <a href="https://doi.org/10.1038/s41467-022-29322-4">https://doi.org/10.1038/s41467-022-29322-4</a></li> <li>Hickey CM, Digianantonio KM, Zimmermann K, et al. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. 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