Nature Reviews Cancer

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data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush c-card--major" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00769-5/MediaObjects/41568_2024_769_Fig1_HTML.png?as=webp 290w, https://media.springernature.com/w485h264/springer-static/image/art%3A10.1038%2Fs41568-024-00769-5/MediaObjects/41568_2024_769_Fig1_HTML.png?as=webp 485w" sizes=" (max-width: 768px) 290px, (max-width: 1200px) 485px, 485px"> <img src="https://media.springernature.com/w485h264/springer-static/image/art%3A10.1038%2Fs41568-024-00769-5/MediaObjects/41568_2024_769_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00769-5" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Chromothripsis in cancer</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16" itemprop="description"> <p>Chromothripsis is an extreme form of chromosome instability that causes the acquisition of multiple genomic aberrations. Simovic-Lorenz and Ernst discuss mechanistic models of chromothripsis and outline its role in cancer development and tumour evolution. Vulnerabilities of chromothriptic tumours that could be therapeutically exploited are also discussed.</p> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Milena Simovic-Lorenz</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Aurélie Ernst</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-11-15" itemprop="datePublished">15 Nov 2024</time> </div> </div> </div> </article> </div> </li> <li class="app-reviews-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41568-024-00768-6/MediaObjects/41568_2024_768_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00768-6/MediaObjects/41568_2024_768_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00768-6/MediaObjects/41568_2024_768_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00768-6" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>In this Review, Wang and Zhang summarize the major findings of genetic and epigenetic association studies performed on cohorts of survivors of childhood cancer, which provide insights into the long-term adverse effects related to cancer therapy, and present suggestions for a future survivorship research strategy to inform precision survivorship care.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Zhaoming Wang</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Jinghui Zhang</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-11-07" itemprop="datePublished">07 Nov 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41568-024-00763-x/MediaObjects/41568_2024_763_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00763-x/MediaObjects/41568_2024_763_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00763-x/MediaObjects/41568_2024_763_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00763-x" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">The present and future of the Cancer Dependency Map</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The Cancer Dependency Map (DepMap) is a data repository and research platform that can be utilized to systematically identify cancer vulnerabilities. Here Arafeh, Shibue et al. outline the current limitations and future strategies to enhance the DepMap project.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Rand Arafeh</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Tsukasa Shibue</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Francisca Vazquez</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Perspective</span></span><time class="c-meta__item" datetime="2024-10-28" itemprop="datePublished">28 Oct 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41568-024-00760-0/MediaObjects/41568_2024_760_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00760-0/MediaObjects/41568_2024_760_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00760-0/MediaObjects/41568_2024_760_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00760-0" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Stemness in solid malignancies: coping with immune attack</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Immunotherapy shows promise in treating cancers by engineering T cells or using antibodies to activate them. However, cancer stem cells (CSCs) resist immunotherapies and drive cancer relapse. In this Review, Agudo and Miao highlight the mechanisms through which normal stem cells and CSCs in solid tumours achieve immune resistance, offering insights for the development of more effective cancer treatments.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Judith Agudo</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yuxuan Miao</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-10-25" itemprop="datePublished">25 Oct 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41568-024-00761-z/MediaObjects/41568_2024_761_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00761-z/MediaObjects/41568_2024_761_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41568-024-00761-z/MediaObjects/41568_2024_761_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00761-z" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Convergent inducers and effectors of T cell paralysis in the tumour microenvironment</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>In this Review, Hanahan et al. discuss how, in response to tumorigenesis, nearly all cell types in the tumour microenvironment can be programmed to mediate — as functionally distinct subtypes — immunosuppressive programmes that result in the inhibition of antitumour T cell activity and the evasion of immune destruction.</p> </div> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Douglas Hanahan</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Olivier Michielin</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Mikael J. Pittet</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-10-24" itemprop="datePublished">24 Oct 2024</time> </div> </article> </div> </li> </ul> </li> <li> <ul class="app-reviews-row__side"> <li class="app-reviews-row__side-item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00754-y" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Emerging strategies to investigate the biology of early cancer</a> </h3> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Ran Zhou</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xiwen Tang</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Yuan Wang</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-10-21" itemprop="datePublished">21 Oct 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__side-item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00757-9" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Epigenomic heterogeneity as a source of tumour evolution</a> </h3> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Marthe Laisné</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Mathieu Lupien</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Céline Vallot</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-10-16" itemprop="datePublished">16 Oct 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__side-item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00755-x" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">New horizons in our understanding of precursor multiple myeloma and early interception</a> </h3> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">David M. Cordas dos Santos</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Rosa Toenges</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Irene M. Ghobrial</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-10-16" itemprop="datePublished">16 Oct 2024</time> </div> </article> </div> </li> <li class="app-reviews-row__side-item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00752-0" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells</a> </h3> </div> </div> <div class="c-card__section c-meta"> <div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Nicolas Rabas</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Rute M. 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Ferreira</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Ilaria Malanchi</span></li> </ul> </div> <span class="c-meta__item" data-test="article.type"><span class="c-meta__type">Review Article</span></span><time class="c-meta__item" datetime="2024-10-10" itemprop="datePublished">10 Oct 2024</time> </div> </article> </div> </li> </ul> </li> </ul> </div> </section> <section id="news-comment" class="u-mb-48 u-mt-24" data-track-component="news comment grid"> <div class="u-container"> <div class="c-section-heading" data-test="title"> <h2 class="u-ma-0"> <a href="/nrc/news-and-comment" class="c-section-heading__link" data-track="click" data-track-action="view all" data-track-label="button"> News & Comment <svg class="c-section-heading__icon" aria-hidden="true" focusable="false" height="16" width="16"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-chevron-right"></use></svg> </a> </h2> </div> <ul class="app-article-list-row"> <li class="app-article-list-row__item"> <div class="u-full-height" data-native-ad-placement="false"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41568-024-00777-5" class="c-card__link u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Dedicated centres and multinational platforms to improve patient care and address early-onset cancers</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>In this Comment, Ben-Aharon et al. advocate for the creation of designated OncoYoung programs to address the unique needs of individuals with early-onset cancer, as well as multinational platforms with dedicated funding to investigate the aetiology of this disease and to develop preventive measures.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Irit Ben-Aharon</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Elizabeth Smyth</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Anna D. 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Thus, it contributes ...</p> <p class="u-ma-0 u-mt-8">Dortmund, Nordrhein-Westfalen (DE)</p> <p class="u-ma-0 u-mt-8">Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V.</p> </div> </div> <div class="u-hide u-show-at-sm" style="max-width: 150px;"> <img src="https://www.nature.com/naturecareers/getasset/ef4d1262-f338-4e69-aa11-197ea7e48e74/" alt="" class="u-ml-8" loading="lazy"> </div> </li> <li class="c-list-group__item u-display-flex"> <div class="u-display-flex u-flex-direction-column"> <h4 class="u-mb-8 u-mt-0"><a href="https://www.nature.com/naturecareers/job/12832439/assistant-professor-tenure-track-group-leader-in-molecular-medicine-at-wcmm/?TrackID=3463&utm_source=widget&utm_medium=referral&utm_campaign=3463" class="u-link-inherit" data-track="click" data-track-action="Rank:(3)" data-track-category="job-list" data-track-label="12832439">Assistant professor (tenure track, group leader) in molecular medicine at WCMM</a></h4> <div class="u-mt-auto c-meta"> <p class="u-ma-0">Assistant professor with tenure track, group leader position in molecular medicine at Wallenberg Centre for Molecular Medicine (WCMM).</p> <p class="u-ma-0 u-mt-8">Umeå, Sweden</p> <p class="u-ma-0 u-mt-8">Umeå University (KBC)</p> </div> </div> <div class="u-hide u-show-at-sm" style="max-width: 150px;"> <img src="https://www.nature.com/naturecareers/getasset/750d3845-9c76-45bf-b28d-ce2d978a542b/" alt="" class="u-ml-8" loading="lazy"> </div> </li> <li class="c-list-group__item u-display-flex"> <div class="u-display-flex u-flex-direction-column"> <h4 class="u-mb-8 u-mt-0"><a href="https://www.nature.com/naturecareers/job/12832391/phd-candidate-m-f-d-analysis-of-microscopic-biomedical-images-ambiom-/?TrackID=3463&utm_source=widget&utm_medium=referral&utm_campaign=3463" class="u-link-inherit" data-track="click" data-track-action="Rank:(4)" data-track-category="job-list" data-track-label="12832391">PhD Candidate (m/f/d): Analysis of Microscopic BIOMedical Images (AMBIOM)</a></h4> <div class="u-mt-auto c-meta"> <p class="u-ma-0">The Leibniz-Institut für Analytische Wissenschaften - ISAS - e. V. develops efficient analytical methods for health research. 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