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<!DOCTYPE html> <html> <head> <meta name="viewport" content="width=device-width" /> <title>Baishideng Publishing Group</title> <link href="/Content/css?v=rb26yubA8f-T2hXbl5_Lk0hga4CBdoXSmzfqDaG2x281" rel="stylesheet"/> <script src="/bundles/modernizr?v=wBEWDufH_8Md-Pbioxomt90vm6tJN2Pyy9u9zHtWsPo1"></script> <script src="/bundles/jquery?v=FVs3ACwOLIVInrAl5sdzR2jrCDmVOWFbZMY6g6Q0ulE1"></script> <script type="text/javascript"> $(function () { $("#statisticFrame").attr("src", "/ManuscriptChart"); }); $(function () { var iFrames = $("#statisticFrame"); iFrames.load(function () { this.style.height = (this.contentWindow.document.body.offsetHeight - 30) + 'px'; }); }); </script> </head> <body> <div class="siteBody"> <div class="index-main cl"> <div class="left fl"> <div class="mnavbar"> <div> <a href="https://www.f6publishing.com/" target="_blank">Submit a Manuscript</a> </div> </div> <div class="mnavbox"> <div class="navselect"> <select id="main_list_1"> <option value="0|https://www.wjgnet.com/bpg/gerinfo/242">Article Processing Charge</option> <option value="1|https://www.wjgnet.com/bpg/GerList/1">General Information</option> <option value="2|https://www.wjgnet.com/bpg/gerinfo/204">Guidelines for Authors</option> <option value="3|https://www.wjgnet.com/bpg/gerinfo/316">Guidelines for Manuscript Decision</option> <option value="4|https://www.wjgnet.com/bpg/GerInfo/287">Guidelines for Manuscript Type and Related Ethics Documents</option> <option value="5|https://www.wjgnet.com/bpg/gerinfo/240">Language Editing Process for Manuscripts Submitted by Non-Native Speakers of English</option> <option value="6|https://www.wjgnet.com/bpg/gerinfo/241">Peer-Review Process</option> <option value="7|https://www.wjgnet.com/bpg/gerinfo/288">Publication Ethics</option> <option value="8|http://www.wjgnet.com/bpg/GerInfo/239">Steps for Submitting Manuscripts</option> <option value="9|https://www.f6publishing.com">Submit a Manuscript</option> <option value="10|https://www.wjgnet.com/1009-3079/Nav/458">世界华人消化杂志手稿出版费缴纳指南</option> <option value="11|https://www.baishideng.com">世界华人消化杂志在线投稿</option> <option value="12|https://www.wjgnet.com/1009-3079/Nav/36">世界华人消化杂志作者投稿指南</option> </select> </div> <div class="gobtn"> <button type="button" class="btn btn-primary" onclick="nav('main_list_1');">Go</button> </div> </div> <div class="mnavbar"> <div> <a href="https://www.f6publishing.com" target="_blank">F6Publishing</a> </div> </div> <div class="mnavbox"> <a href="https://www.f6publishing.com" target="_blank"> <img style="width:100%;" src="https://bsdwebstorage.blob.core.windows.net/journalqrcodes/e6950aac-b0ce-4ede-ba7a-3456aff9351a.png" /> </a> </div> <div class="mnavbar"> <div> Publisher Login </div> </div> <div class="mnavbox"> <a href="https://admin.f6publishing.com/" target="_blank"> <img style="width:100%;margin-bottom:5px;" src="https://bsdwebstorage.blob.core.windows.net/journalqrcodes/2b965753-d859-4f2b-8521-c5f4c18e2383.png" /> </a> <a href="https://referencecitationanalysis.com/forms/admin/login" target="_blank"> <img style="width:100%;" src="https://bsdwebstorage.blob.core.windows.net/journalqrcodes/34593440-275e-4989-afdb-4de6008f6b0e.png" /> </a> </div> <div class="mnavbar"> <div> Manuscript Statistics </div> </div> <div class="mnavbox"> <div class="framepart cl"> <iframe id="statisticFrame" name="statisticFrame" src="" height="790" marginheight="0" marginwidth="0" width="100%" scrolling="no" frameborder="0"></iframe> </div> </div> <div class="mnavbar"> <div> <a href="https://www.f6publishing.com/ArticlesInPress" target="_blank">Articles In Press</a> </div> </div> <div class="mnavbox"> <div class="articlelist cl"> <div class="articleitem cl"> <div class="num fl"> 1 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=100312" target="_blank"> Yi F, Wu H, Zhao HK. Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage. <i>World J Clin Cases</i> 2024; In press </a> </div> <div class="count"> 2024-11-27 | Browse: 1 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 2 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=102273" target="_blank"> Shi J, Zhu X, Yang JB. Advances and challenges in molecular understanding, early detection, and targeted treatment of liver cancer. <i>World J Hepatol</i> 2024; In press </a> </div> <div class="count"> 2024-11-27 | Browse: 1 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 3 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=97406" target="_blank"> Siddiqi AK, Shafiq A, Ahmed M, Anwer A, Maniya MT, Ahmed A, Chachar MA, Hasibuzzaman MA. Therapeutic use of music listening in patients undergoing invasive coronary procedures: A meta-analysis. <i>World J Cardiol</i> 2024; In press </a> </div> <div class="count"> 2024-11-27 | Browse: 5 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 4 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=99332" target="_blank"> Yang TF, Kong MW. Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma. <i>World J Gastrointest Oncol</i> 2024; In press </a> </div> <div class="count"> 2024-11-27 | Browse: 2 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 5 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=101769" target="_blank"> Al-Beltagi M, Choueiry E, Alahmadi N, Demerdash Z, Helmi Ayesh W, Al-Said K, Al-Haddad F, Shaaban SY, Tawfik E. Diet fortification for mild and moderate picky eating in typically developed children: Opinion review of Middle East consensus. <i>World J Clin Pediatr</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 10 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 6 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=101350" target="_blank"> Yang JM, Wang Y, Zhang YQ, Zhang HL, Bo ZY. Bo’s abdominal acupuncture treatment for adult-onset Still's disease: A case report. <i>World J Clin Cases</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 14 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 7 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=101115" target="_blank"> Govindarajan KK. Relevance of epidemiology data in trauma management. <i>World J Clin Cases</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 11 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 8 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=99848" target="_blank"> Pellegrino R, Palladino G, Izzo M, De Costanzo I, Landa F, Federico A, Gravina AG. Water-assisted colonoscopy in inflammatory bowel diseases: From technical implications to diagnostic and therapeutic potentials. <i>World J Gastrointest Endosc</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 13 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 9 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=99663" target="_blank"> Abhilash KPP, Nellimootil MV, Chacko B, Hazra D, Coelho V, Jesudasan JE, Gunasekaran K, Thomas L, Ramchandra MA, Melchizedek J, Gunaraj HM, Moorthy M, Peter JV. Risk of COVID-19 infection among frontline healthcare workers during the COVID-19 pandemic. <i>World J Virol</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 12 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 10 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=99421" target="_blank"> Luo M, Lu XX, Meng DY, Hu J. Small cell lung cancer with peripheral neuropathy as the first symptom: Two case reports. <i>World J Clin Cases</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 12 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 11 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=99286" target="_blank"> Ghandour S, Lebedev A, Tung WS, Semianov K, Semjanow A, DiGiovanni CW, Ashkani-Esfahani S, Pineda LB. Utilization of artificial intelligence in the diagnosis of pes planus and pes cavus with a smartphone camera. <i>World J Orthop</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 14 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 12 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=98379" target="_blank"> Musharaf I, Nashwan AJ. Association of interleukin-6 with acute lung injury risk and disease severity in sepsis. World J Clinical Cases 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 10 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 13 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=99053" target="_blank"> Wang D, Wang YS, Zhao HM, Lu P, Li M, Li W, Cui HT, Zhang ZY, Lv SQ. Plantamajoside improves type 2 diabetes mellitus pancreatic β-cell damage by inhibiting endoplasmic reticulum stress through Dnajc1 up-regulation. <i>World J Diabetes</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 19 | Download: 22 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 14 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=98359" target="_blank"> <p>Varama A. Revisiting dexamethasone dosage in COVID-19 management. <i><i>World J Virol</i></i> 2025; 14(1): 98359</p> </a> </div> <div class="count"> 2024-11-26 | Browse: 10 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 15 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=98897" target="_blank"> Fei SJ, Luo JY, Wang WH, Guo LX, Pan Q. Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2 diabetes mellitus. <i>World J Diabetes</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 12 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 16 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=100371" target="_blank"> Tang SS, Zhao XF, An XD, Sun WJ, Kang XM, Sun YT, Jiang LL, Gao Q, Li ZH, Ji HY, Lian FM. Classification and identification of risk factors for type 2 diabetes. <i>World J Diabetes</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 9 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 17 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=99122" target="_blank"> Wang L, Zhang SM, Chen XQ. Early identification and multidisciplinary management of immune checkpoint inhibitors associated colitis can improve patient outcomes. <i>World J Gastrointest Surg</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 14 | Download: 0 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 18 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=95871" target="_blank"> Min HC, Zhang CY, Wang FY, Yu XH, Tang SH, Zhu HW, Zhao YG, Liu JL, Wang J, Guo JH, Zhang XM, Yang YS. Prevalence of Helicobacter pylori infection in Chinese military personnel: A cross-sectional, multicenter-based study. <i>World J Gastroenterol</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 54 | Download: 31 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 19 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=97239" target="_blank"> Niu JW, Zhang GC, Ning W, Liu HB, Yang H, Li CF. Clinical effects of phospholipase D2 in attenuating acute pancreatitis. <i>World J Gastroenterol</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 29 | Download: 30 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 20 </div> <div class="item fl"> <div class="title"> <a href="https://www.f6publishing.com/ArticleInPressPubDetail?id=97963" target="_blank"> Albuquerque A, Rao SSC. Controversies in fecal incontinence. <i>World J Gastroenterol</i> 2024; In press </a> </div> <div class="count"> 2024-11-26 | Browse: 15 | Download: 0 </div> </div> </div> <div class="more"> <span>385 items</span>  <a href="https://www.f6publishing.com/ArticlesInPress" target="_blank">Read more >></a> </div> </div> </div> <div class="mnavbar"> <div> <a href="https://www.f6publishing.com/AuthorReviews" target="_blank">Author Reviews</a> </div> </div> <div class="mnavbox"> <div class="articlelist cl"> <div class="articleitem cl"> <div class="num fl"> 1 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/101901.htm" class="author-comment" target="_blank"> "I believed that an editing certificate for non-native authors was unnecessary, especially since the editing institute made only minimal ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/101901.htm" target="_blank" class="author-comment"> "I believed that an editing certificate for non-native authors was unnecessary, especially since the editing institute made only minimal corrections in my case, which did not affect the content. Additionally, the limited revision time posed a challenge. It was somewhat inconvenient to choose an editing institute because a longer revision period was required by the institute. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Tsang HY, Yong CC, Wang HP. Mesenteric ischemia with intrasplenic gas: A case report. <em>World J Clin Cases</em> 2025; 13(7): 101901 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 2 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5055.htm" class="author-comment" target="_blank"> "We appreciate the thoroughness of your editorial team and the timely communication at each stage. The online submission process of ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5055.htm" target="_blank" class="author-comment"> "We appreciate the thoroughness of your editorial team and the timely communication at each stage. The online submission process of WJG is convenient and fast, the publication rules are standardized, and the review cycle is satisfactory. Thank you for your detailed comments and for providing valuable insights throughout the review process. Your constructive feedback has significantly enhanced the quality and clarity of our manuscript.The professionalism and rigor of the publishing process were exemplary, ensuring a smooth and collaborative experience. The peer reviewers are professional, the review report is detailed, and the content of the review report is fair and objective. Article editing and typesetting quality is high. WJG has strong credibility. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Wang LL, Lu YM, Wang YH, Wang YF, Fang RF, Sai WL, Yao DF, Yao M. Carnitine palmitoyltransferase-II inactivity promotes malignant progression of metabolic dysfunction-associated fatty liver disease <i>via</i> liver cancer stem cell activation. <em>World J Gastroenterol</em> 2024; 30(47): 5055-5069 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 3 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/4983.htm" class="author-comment" target="_blank"> "Dear Editorial Team of World Journal of Gastroenterology We would like to express our sincere gratitude for the professional and ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/4983.htm" target="_blank" class="author-comment"> "Dear Editorial Team of World Journal of Gastroenterology We would like to express our sincere gratitude for the professional and dedicated approach of your journal throughout the process. We are thoroughly satisfied with the experience and collaboration. We hope to have more opportunities to contribute to the journal in the future, not only by submitting manuscripts but also by participating in peer-review activities. Thank you once again for your support and professionalism. Best regards, " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Luong TV, Nguyen NVD, Le LD, Nguyen Hoang Minh H, Dang HNN. Enhancing global hepatocellular carcinoma management: Bridging Eastern and Western perspectives on dexamethasone and N-acetylcysteine before transarterial chemoembolization. <em>World J Gastroenterol</em> 2024; 30(47): 4983-4990 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 4 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5092.htm" class="author-comment" target="_blank"> "We would like to express our sincere gratitude for the professional and dedicated approach of your journal throughout the process. ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5092.htm" target="_blank" class="author-comment"> "We would like to express our sincere gratitude for the professional and dedicated approach of your journal throughout the process. We are thoroughly satisfied with the experience and collaboration. We hope to have more opportunities to contribute to the journal in the future, not only by submitting manuscripts but also by participating in peer-review activities. Thank you once again for your support and professionalism. Best regards, Hai Nguyen Ngoc Dang " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Nguyen NTY, Luong TV, Nguyen DX, Le LD, Dang HNN. Understanding gastric metastasis of small cell lung carcinoma: Insights from case reports and clinical implications. <em>World J Gastroenterol</em> 2024; 30(47): 5092-5096 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 5 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/4991.htm" class="author-comment" target="_blank"> "Our manuscript was accepted 2 months after submission. The speed is satisfactory. The detailed process of review and editing is ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/4991.htm" target="_blank" class="author-comment"> "Our manuscript was accepted 2 months after submission. The speed is satisfactory. The detailed process of review and editing is transparent, which offered great help for authors to track the status of the manuscript. The help desk and editors would respond to our inquiry in time. Thanks for the publication of our manuscript! We are looking forward to the future cooperation with your journal! " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Yao SY, Li XM, Cai T, Li Y, Liang LX, Liu XM, Lei YF, Zhu Y, Wang F. <i>Helicobacter pylori</i> infection is associated with the risk and phenotypes of cholelithiasis: A multi-center study and meta-analysis. <em>World J Gastroenterol</em> 2024; 30(47): 4991-5006 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 6 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/683.htm" class="author-comment" target="_blank"> "I feel that the unbiased peer review report improved the quality of the manuscript after my revision based on the peer reviewer's ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/683.htm" target="_blank" class="author-comment"> "I feel that the unbiased peer review report improved the quality of the manuscript after my revision based on the peer reviewer's input. Overall, my experience was good, with robust editorial process. I am particularly impressed with the new "References relativities check" which ensures all references are relevant and prevents unnecessary self-citation. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Sunder T. Thoughts on recent articles on cardiopulmonary resuscitation. <em>World J Cardiol</em> 2024; 16(12): 683-688 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 7 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2384.htm" class="author-comment" target="_blank"> "Overall, the process of the submition and peer review process is good. Overall, the process of the submition and peer review process ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2384.htm" target="_blank" class="author-comment"> "Overall, the process of the submition and peer review process is good. Overall, the process of the submition and peer review process is good. Overall, the process of the submition and peer review process is good. Overall, the process of the submition and peer review process is good. Overall, the process of the submition and peer review process is good. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Chen LH, Ran XW. Relevance of macrophages in the wound healing process among individuals afflicted with diabetic foot ulcers. <em>World J Diabetes</em> 2024; 15(12): 2384-2386 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 8 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/720.htm" class="author-comment" target="_blank"> "The overall process from submission to publication of the article is satisfactory. However, for authors from non-native ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/720.htm" target="_blank" class="author-comment"> "The overall process from submission to publication of the article is satisfactory. However, for authors from non-native English-speaking countries, it is advisable to approach the requirement of using third-party language editing services with more flexibility. It is recommended to retain certain subtle formatting details in the table, such as bolding those key data. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Guo ZK, Chen PG, Li YX, Jiao H, Kong XH, Bai S, Li XF, Liu AJ, Wang GL. Independent prognostic value of lipocalin-2 in congenital heart disease-associated pulmonary artery hypertension. <em>World J Cardiol</em> 2024; 16(12): 720-730 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 9 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5070.htm" class="author-comment" target="_blank"> "I would like to express my sincere gratitude to the editors who worked on my manuscript. However, I must note that the initial ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5070.htm" target="_blank" class="author-comment"> "I would like to express my sincere gratitude to the editors who worked on my manuscript. However, I must note that the initial peer-review process took 2.5 months. Given that my manuscript focuses on pediatric gastroenterology, I can understand the delay in the peer-review process. Unfortunately, the delay in completing the peer-review contributed to my manuscript being shifted from an editorial to a letter to the editor, as other manuscripts that were accepted earlier were prioritized for the editorial section. I feel this outcome was not entirely fair. That said, I deeply appreciate the editors’ efforts and dedication in handling my manuscript, and I thank them sincerely for their support. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Yodoshi T. Exploring non-invasive diagnostics and non-imaging approaches for pediatric metabolic dysfunction-associated steatotic liver disease. <em>World J Gastroenterol</em> 2024; 30(47): 5070-5075 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 10 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/707.htm" class="author-comment" target="_blank"> "Thank you for your detailed comments and for providing valuable insights throughout the review process. Your constructive feedback ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/707.htm" target="_blank" class="author-comment"> "Thank you for your detailed comments and for providing valuable insights throughout the review process. Your constructive feedback has significantly enhanced the quality and clarity of our manuscript. We appreciate the thoroughness of your editorial team and the timely communication at each stage. The professionalism and rigor of the publishing process were exemplary, ensuring a smooth and collaborative experience. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Hassan M, Vinagolu-Baur J, Li V, Frasier K, Herrick G, Scotto T, Rankin E. E-cigarettes and arterial health: A review of the link between vaping and atherosclerosis progression. <em>World J Cardiol</em> 2024; 16(12): 707-719 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 11 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/944.htm" class="author-comment" target="_blank"> "The online submission process of the journal is convenient and fast, the publication rules are standardized, and the review cycle ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/944.htm" target="_blank" class="author-comment"> "The online submission process of the journal is convenient and fast, the publication rules are standardized, and the review cycle is satisfactory. The peer reviewers are professional, the review report is detailed, and the content of the review report is fair and objective. Article editing and typesetting quality is high. The journal has strong credibility. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Xiao KZ, Liao G, Huang GY, Huang YL, Gu RH. Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice. <em>World J Stem Cells</em> 2024; 16(11): 944-955 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 12 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/673.htm" class="author-comment" target="_blank"> "Only concern during the publication was the delay in peer review. Apart from this everything else was flawless and hassle free as ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1949-8462/full/v16/i12/673.htm" target="_blank" class="author-comment"> "Only concern during the publication was the delay in peer review. Apart from this everything else was flawless and hassle free as always. The review report otherwise was straightforward, relevant and helpful in improving the overall quality of the manuscript. Perhaps the journal could find some way to circumvent the delay in allocation of expert peer reviewers. perhaps make a pool of the best and experienced reviewers and periodically keep inviting them instead of recruiting newer reviewers who may not always be able to provide a quality review in a timely manner. Thank you very much for the overall journey. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Niyogi SG, Batta A, Mohan B. Balancing bleeding, thrombosis and myocardial injury: A call for balance and precision medicine for aspirin in neurosurgery. <em>World J Cardiol</em> 2024; 16(12): 673-676 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 13 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/900.htm" class="author-comment" target="_blank"> "It was really good opportunity for me to have the chance to work with World Journal of Stem cells. The review process was very ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/900.htm" target="_blank" class="author-comment"> "It was really good opportunity for me to have the chance to work with World Journal of Stem cells. The review process was very satisfied. And the revision request from editor and reviewers was so helpful, which I think make this specific manuscript been improved. I hope that I can contribute another article publication next time. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Park SH. Potential of ginsenoside Rg1 to treat aplastic anemia <i>via</i> mitogen activated protein kinase pathway in cyclophosphamide-induced myelosuppression mouse model. <em>World J Stem Cells</em> 2024; 16(11): 900-905 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 14 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/985.htm" class="author-comment" target="_blank"> "The Grading of peer reviewers should not be published online because grading is arbitrary and can vary between reviewers. For example, ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/985.htm" target="_blank" class="author-comment"> "The Grading of peer reviewers should not be published online because grading is arbitrary and can vary between reviewers. For example, publishing "C" category puts a negative image in the mind of the reader while the paper may be very good in the eyes of the reader. This grading adds bias in the mind of the reader " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Haider KH. Melatonin-based priming of stem cells to alleviate oxidative stress. <em>World J Stem Cells</em> 2024; 16(11): 985-989 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 15 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/906.htm" class="author-comment" target="_blank"> "I am very satisfied with the whole submission process, once again thank the editors for their hard work and dedication.My paper was ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i11/906.htm" target="_blank" class="author-comment"> "I am very satisfied with the whole submission process, once again thank the editors for their hard work and dedication.My paper was received and published at the right time.I hope I can have the honor of being the reviewer of the magazine, to repay all the hard work of the editors. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Zhang WY, Wang HB, Deng CY. Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells. <em>World J Stem Cells</em> 2024; 16(11): 906-925 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 16 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4950.htm" class="author-comment" target="_blank"> "We greatly appreciate the time and effort dedicated into our manuscript by the Editor-in-Chief, Associate Editor, Science Editor, ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4950.htm" target="_blank" class="author-comment"> "We greatly appreciate the time and effort dedicated into our manuscript by the Editor-in-Chief, Associate Editor, Science Editor, Reviewer, Editorial Director, Language Editor, and Production Editor. Thank you again for your support and for the opportunity to publish in the World Journal of Gastroenterology. It has been a pleasure to collaborate with your publishing house. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Emelyanova MA, Ikonnikova AY. Utilization of molecular genetic approaches for colorectal cancer screening. <em>World J Gastroenterol</em> 2024; 30(46): 4950-4957 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 17 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4880.htm" class="author-comment" target="_blank"> "We greatly appreciate quality comments from the editorial team. All comments are important to help us improve the manuscript. In ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4880.htm" target="_blank" class="author-comment"> "We greatly appreciate quality comments from the editorial team. All comments are important to help us improve the manuscript. In addition, we would like to comment on the time to go online, which needs to be guaranteed as announced, because this step is very important for us to complete projects as planned. Best Regards. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Nguyen TT, Ho TC, Bui HTT, Tran VK, Nguyen TT. Multi-clustering study on the association between human leukocyte antigen<i>-DP-DQ</i> and hepatitis B virus-related hepatocellular carcinoma and cirrhosis in Viet Nam. <em>World J Gastroenterol</em> 2024; 30(46): 4880-4903 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 18 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5086.htm" class="author-comment" target="_blank"> "We are satisfied with the online submission system and peer review report. The assistant editor, peer reviewers, language editor, ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5086.htm" target="_blank" class="author-comment"> "We are satisfied with the online submission system and peer review report. The assistant editor, peer reviewers, language editor, and production team provided valuable feedback, ensuring the manuscript was of high quality. The submission procedure is both efficient and pleasant. The feedback from editors and reviewers is beneficial and conducted in a professional manner. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Ramoni D, Liberale L, Montecucco F. Inflammatory biomarkers as cost-effective predictive tools in metabolic dysfunction-associated fatty liver disease. <em>World J Gastroenterol</em> 2024; 30(47): 5086-5091 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 19 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5097.htm" class="author-comment" target="_blank"> "I found the submission process at F6Publishing to be user-friendly, with clear guidelines and an intuitive interface. The manuscript ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i47/5097.htm" target="_blank" class="author-comment"> "I found the submission process at F6Publishing to be user-friendly, with clear guidelines and an intuitive interface. The manuscript submission steps were straightforward, and I encountered no technical issues. Response times from the editorial team were prompt, and communication was professional throughout the process. The platform's support team was responsive and helpful, providing timely assistance when needed. Overall, F6Publishing provides a well-organized platform that simplifies the submission and review process for authors, enhancing the overall publishing experience. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Deng ZH, Li X, Liu L, Zeng HM, Chen BF, Peng J. Role of gut microbiota and <i>Helicobacter pylori</i> in inflammatory bowel disease through immune-mediated synergistic actions. <em>World J Gastroenterol</em> 2024; 30(47): 5097-5103 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 20 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4947.htm" class="author-comment" target="_blank"> "I would like to extend my heartfelt gratitude to the editorial team of the World Journal of Gastroenterology. Their professionalism, ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4947.htm" target="_blank" class="author-comment"> "I would like to extend my heartfelt gratitude to the editorial team of the World Journal of Gastroenterology. Their professionalism, efficient processes, and constructive feedback greatly facilitate the publication experience. The transparent communication and dedication to upholding high academic standards are truly commendable. I appreciate their efforts in advancing scientific knowledge and fostering collaboration, and I look forward to future opportunities to work with the journal. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Huang W, Huang YQ, Yang GL. Limitations and suggestions for type 2 diabetes mellitus and pancreatic neuroendocrine tumors based on meta-analysis. <em>World J Gastroenterol</em> 2024; 30(46): 4947-4949 </div> </div> </div> <div class="more"> <span>17061 items</span>  <a href="https://www.f6publishing.com/AuthorReviews" target="_blank">Read more >></a> </div> </div> </div> <div class="mnavbar"> <div> <a href="https://www.f6publishing.com/ArticleQualityTrackings" target="_blank">Article Quality Tracking-Peer-Review</a> </div> </div> <div class="mnavbox"> <div class="articlelist cl"> <div class="articleitem cl"> <div class="num fl"> 1 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2338.htm" class="author-comment" target="_blank"> "This is a study that validates the effect of plant-based medicine in promoting the healing of diabetic wounds through basic research. ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2338.htm" target="_blank" class="author-comment"> "This is a study that validates the effect of plant-based medicine in promoting the healing of diabetic wounds through basic research. The study has significant clinical implications. In traditional Chinese medicine, Zi Cao is used to treat burns and scalds. The abstract of this study suggests that Shikonin is a natural remedy effective in treating diabetic wounds. However, this lacks support from clinical literature. I recommend further exploration of its clinical effects and reporting in future clinical practice. Additionally, it is worth researching the additional benefits of plant-based antidiabetic medications in treating difficult-to-heal wounds (Phytomedicine. 2024 Nov;134:155990)." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Cen LS, Cao Y, Zhou YM, Guo J, Xue JW. Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds. <em>World J Diabetes</em> 2024; 15(12): 2338-2352 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 2 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2338.htm" class="author-comment" target="_blank"> "Overall, the manuscript presented scientific findings with clarity and precision. The ethical approval form provided by the author ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2338.htm" target="_blank" class="author-comment"> "Overall, the manuscript presented scientific findings with clarity and precision. The ethical approval form provided by the author meets the requirements. However, I still found some drawbacks. It is very difficult to understand these a P < 0.05, b P < 0.01, c P < 0.001 in figure legend of Figures 1,4 and 5 due to missing the group comparison information. It is well reported that the phosphorylated AMPK performs the metabolism regulation, the authors should evaluate the protein level of P-AMPK when measuring AMPK. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Cen LS, Cao Y, Zhou YM, Guo J, Xue JW. Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds. <em>World J Diabetes</em> 2024; 15(12): 2338-2352 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 3 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/95004.htm" class="author-comment" target="_blank"> "1. Inclusion of pediatric patients - would this skew the data and interpretation as meniscal injury repair timing in a child and adult ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/95004.htm" target="_blank" class="author-comment"> "1. Inclusion of pediatric patients - would this skew the data and interpretation as meniscal injury repair timing in a child and adult may not be comparable 2. Type of injury such as anterior / posterior/ extrusion may have an impact on the timing of management and may be a confounding factor 3. The surgery type may also influence the timing of management and act as a confounding factor" </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Javid K, Akins X, Lemaster NG, Ahmad A, Stone AV. Impact of time between meniscal injury and isolated meniscus repair on post-operative outcomes: A systematic review. <em>World J Clin Cases</em> 2025; 13(7): 95004 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 4 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/95430.htm" class="author-comment" target="_blank"> "1. Exclusion criteria is not exhaustive as certain conditions like tumor lysis syndrome can cause hypernatremia causing confounding ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/95430.htm" target="_blank" class="author-comment"> "1. Exclusion criteria is not exhaustive as certain conditions like tumor lysis syndrome can cause hypernatremia causing confounding bias 2. How reliable are the serum sodium values - samples from central lines with concurrent fluid infusion, samples not obtained from free flow of peripheral veins, etc can be false positive, with difficulty in analysis 3. Surgical causes such as post procedure related elevated sodium, necrotising fasciitis, tissue debridement may also need to be looked into. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Shi MQ, Chen J, Ji FH, Zhou H, Peng K, Wang J, Fan CL, Wang X, Wang Y. Prognostic impact of hypernatremia for septic shock patients in the intensive care unit. <em>World J Clin Cases</em> 2025; 13(7): 95430 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 5 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/98000.htm" class="author-comment" target="_blank"> "1. "we will briefly discuss the more frequent late effects of childhood cancer and the main preventive strategies". The manuscript ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i7/98000.htm" target="_blank" class="author-comment"> "1. "we will briefly discuss the more frequent late effects of childhood cancer and the main preventive strategies". The manuscript covers the late effects in details, but the prevention aspect could be included. 2. Screening of vulnerable individuals at the appropriate time intervals is another strategy in the child cancer survivor group. This also includes risk based screening. 3. Tranistional care is another important aspect of child cancer survivors." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Roganovic J. Late effects of the treatment of childhood cancer. <em>World J Clin Cases</em> 2025; 13(7): 98000 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 6 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-5204/full/v16/i12/4537.htm" class="author-comment" target="_blank"> "The authors highlighted the application of the controlled nutritional status (CONUT) score in the prognostic assessment of patients ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-5204/full/v16/i12/4537.htm" target="_blank" class="author-comment"> "The authors highlighted the application of the controlled nutritional status (CONUT) score in the prognostic assessment of patients with colorectal cancer (CRC) and analyzed its potential usage in predicting immunonutrition. The authors first discussed the importance of nutritional status in CRC treatment and prognosis. Then, the authors underlined the CONUT score as a low-cost, easy-to-use tool, which helps in personalized treatment for CRC patients. The authors cited abundant literatures, combined with a variety of nutrition and inflammation-related indicators. In particular, CONUT was compared and analyzed with tumor-node-metastasis (TNM) stage and muscle mass index (SMI), further confirming the predictive value of CONUT in clinical practice. The language in this Editorial is concise, with a logical flow and no noticeable grammatical or spelling errors. Although other prognostic tools such as neutrophil-to-lymphocyte ratio (NLR), and Glasgow prognostic score (GPS) are mentioned, a more in-depth comparative analysis could potentially clarify the advantages of CONUT in specific clinical scenarios. Furthermore, the connection between CONUT and immune checkpoint inhibitors (ICI) can be strengthened by mechanistic insights or specific examples. Overall, the authors provide valuable insights into the clinical potential of the CONUT score and its future application. Further studies on the applicability of the CONUT score in different patient subgroups and its synergy with other nutritional or inflammatory markers are necessary to fully promote its clinical application. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Berardi R, Chiariotti R, Mentrasti G. Is nutritional status a new indicator to use in clinical practice for colorectal cancer patients? <em>World J Gastrointest Oncol</em> 2024; 16(12): 4537-4542 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 7 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4950.htm" class="author-comment" target="_blank"> "The authors underscored the significance of molecular genetic approaches in colorectal cancer (CRC) screening. The article outlines ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4950.htm" target="_blank" class="author-comment"> "The authors underscored the significance of molecular genetic approaches in colorectal cancer (CRC) screening. The article outlines the current landscape of CRC screening, highlighting the shift from conventional, invasive methods to non-invasive, molecular-based techniques. The emphasis on the non-invasive nature of these methods and their potential to personalize screening programs based on individual risk assessment is particularly well stressed. Furthermore, the authors highlighted the necessity for ongoing research to refine these molecular genetic techniques, given the current limitations in sensitivity and specificity, especially in detecting precancerous lesions. For example, a better understanding of the genetic and epigenetic alterations in CRC development is crucial for early detection of colorectal cancer. Notably, this Letter focuses on the integration of molecular genetic approaches with traditional screening methods to enhance early detection rates. The discussion on the combination of liquid biopsy and multi-omics strategies to improve screening accuracy is particularly enlightening. The references cited are appropriate. The language in this Letter is concise with no noticeable grammatical or spelling errors. In conclusion, the author provides an insightful overview of the clinical potential of molecular genetic approaches in CRC screening and advocates for future research to uncover deeper mechanistic insights. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Emelyanova MA, Ikonnikova AY. Utilization of molecular genetic approaches for colorectal cancer screening. <em>World J Gastroenterol</em> 2024; 30(46): 4950-4957 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 8 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i11/1772.htm" class="author-comment" target="_blank"> "The adolescent years, characterized by profound physical and psychological changes, can be a time of both excitement and significant ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i11/1772.htm" target="_blank" class="author-comment"> "The adolescent years, characterized by profound physical and psychological changes, can be a time of both excitement and significant mental health challenges. Depression has emerged as a prevalent issue among adolescents globally, necessitating a comprehensive approach to its multifaceted etiology. A recent study examining the relationships among negative life events, dysfunctional attitudes, social support, and depressive symptoms in Chinese adolescents provides valuable insights into the complex interplay of factors contributing to adolescent depression. Utilizing a moderated mediation model, the authors explore how these factors interact and contribute to depression onset. This article delves into the study's key findings, emphasizing the need for interventions that enhance social support, address dysfunctional attitudes, and offer coping strategies for negative life events. Such insights are crucial for informing clinical practices and policies aimed at improving adolescent mental health." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Zhang Y, Hei MY, Wang MZ, Zhang JG, Wang S. Unraveling the complexities of adolescent depression: A call for action. <em>World J Psychiatry</em> 2024; 14(11): 1772-1778 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 9 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i11/1766.htm" class="author-comment" target="_blank"> "The article, "Holistic Approaches to Mitigating Psychological Distress in Gynecological Cancer Patients" by Haewon Byeon, explores ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i11/1766.htm" target="_blank" class="author-comment"> "The article, "Holistic Approaches to Mitigating Psychological Distress in Gynecological Cancer Patients" by Haewon Byeon, explores the profound psychological impacts faced by patients with gynecological malignancies and proposes comprehensive strategies to enhance their quality of life (QoL). Building on existing analyses, the study emphasizes the exacerbating role of anxiety and depression in these patients and highlights promising interventions such as physical exercise and digital health solutions. By advocating for a holistic care model that integrates both physical and emotional support, the article underscores the importance of training healthcare providers to recognize psychological distress and improving access to specialist care through streamlined diagnostic pathways. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Byeon H. Holistic approaches to mitigating psychological distress in gynecological cancer patients. <em>World J Psychiatry</em> 2024; 14(11): 1766-1771 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 10 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i11/1779.htm" class="author-comment" target="_blank"> "The article, "Enhancing Adolescent Mental Health through Cognitive and Social Support: Insights from a Study on Depression in Chinese ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i11/1779.htm" target="_blank" class="author-comment"> "The article, "Enhancing Adolescent Mental Health through Cognitive and Social Support: Insights from a Study on Depression in Chinese Adolescents," provides a timely and relevant exploration of adolescent mental health, a topic of increasing global concern. By examining cognitive and social support mechanisms, the study contributes valuable insights into interventions that can enhance mental well-being. The research is underpinned by a robust methodological framework, involving experienced researchers from Inje University's Department of Digital Anti-aging Healthcare and Medical Big Data Research Center, which ensures the reliability and impact of its findings. Additionally, the focus on Chinese adolescents offers targeted insights into a demographic often underrepresented in global studies, enriching the understanding of mental health challenges within this group. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Okpete UE, Byeon H. Enhancing adolescent mental health through cognitive and social support: Insights from study on depression in Chinese adolescents. <em>World J Psychiatry</em> 2024; 14(11): 1779-1782 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 11 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4964.htm" class="author-comment" target="_blank"> "The author effectively highlighted both the benefits and limitations of Fanlian Huazhuo Formula (FLHZF) in suppressing the development ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4964.htm" target="_blank" class="author-comment"> "The author effectively highlighted both the benefits and limitations of Fanlian Huazhuo Formula (FLHZF) in suppressing the development of metabolic dysfunction-associated steatotic liver disease (MASLD). In addition, the author emphasized the need for further mechanistic studies to elucidate the metabolic perturbations induced by FLHZF. Strikingly, the importance of investigating phenotypic and mechanistic effects in female mice was stressed, given the exclusive use of male mice as animal models in the original research. The references cited appear to include the latest and most relevant studies in MASLD, lipogenesis, and herbal pharmacotherapy. The language in this Letter is clear and concise, with a logical flow and no noticeable grammatical or spelling errors. Overall, the author provides a comprehensive summary of the therapeutic potential of FLHZF in MASLD and effectively calls for future studies to gain deeper mechanistic insights and broaden the applicability of these findings." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Singla B. Fanlian Huazhuo Formula: A promising herbal preparation for metabolic liver disease. <em>World J Gastroenterol</em> 2024; 30(46): 4964-4968 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 12 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2311.htm" class="author-comment" target="_blank"> "The ethical approval form provided by the author meets the requirement. The methods are effective and can be repeated by fellow ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2311.htm" target="_blank" class="author-comment"> "The ethical approval form provided by the author meets the requirement. The methods are effective and can be repeated by fellow researchers. The results of this study are authentic, reliable and validate the initial hypothesis. Only one mistake should be corrected. Paragraph 4 was repeated and should be deleted. The tables, graphs, and figures were constructed and annotated well. The biostatistics data was generally right and had no mistakes. However, one suggestion should be mentioned, and I hope the authors consider it. The data on D1, D15, and M6 can be seen as time series data. The treatment can be seen as a fixed effect factor. In order to find out how the three-week exercise program affects muscle strength and joint mobility in DPN patients, the linear mixed-effects models (LME) for time series data are strongly suggested. The calculated results should be added and discussed further. The authors have scientifically and reasonably cited the lasted references in the field that are important and relevant to the scientific questions and research hypotheses addressed in this study. The language in the article is generally correct, clear, and concise in expressing the message that the authors are trying to convey." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Novaković-Bursać S, Talić G, Tomić N, Škrbić R, Soldatovic I. Effect of three-week exercise program on muscle strength and joint mobility in patients with diabetic polyneuropathy: Randomized controlled trial. <em>World J Diabetes</em> 2024; 15(12): 2311-2321 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 13 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i45/4859.htm" class="author-comment" target="_blank"> "The paper is well written, easy to read and well structured. There are no grammatical or spelling errors throughtout the text. ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i45/4859.htm" target="_blank" class="author-comment"> "The paper is well written, easy to read and well structured. There are no grammatical or spelling errors throughtout the text. Considering the importance of acute pancreatitis diagnosis, treatment and severe complications, along with the increasing incidence of metabolic syndrome (a modern disease), I think this paper is welcomed and relevant for medical daily practice. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Quan Y, Yang XJ. Metabolic syndrome and acute pancreatitis: Current status and future prospects. <em>World J Gastroenterol</em> 2024; 30(45): 4859-4863 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 14 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i5/95183.htm" class="author-comment" target="_blank"> "1. Title does not indicate the type of study. The manuscript type (randomised control trial) can be included in the title. 2. What ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i5/95183.htm" target="_blank" class="author-comment"> "1. Title does not indicate the type of study. The manuscript type (randomised control trial) can be included in the title. 2. What were the literacy levels / sugar control / medication dosages before entering the trial? 3. The groups appear heterogeneous in terms of the type of nursing care given. This appears to introduce bias, which is a study limitation. 4. Blinding could have been included" </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Shi H, Liu C, Luo HY. Impact of community public health care on treatment effect, health cognition, and self-management in patients with type 2 diabetes. <em>World J Clin Cases</em> 2025; 13(5): 95183 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 15 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i5/95879.htm" class="author-comment" target="_blank"> "1. Title has a language error. "How often do we think off in clinical practice?" Typographic error 'off' to be corrected 2. "By ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i5/95879.htm" target="_blank" class="author-comment"> "1. Title has a language error. "How often do we think off in clinical practice?" Typographic error 'off' to be corrected 2. "By addressing the primary conditions causing secondary diabetes, such as excising pituitary adenomas, providing glucocorticoid supplementation, and implementing symptomatic treatments, patients can experience a significant decrease in blood glucose levels" Requires rephrasing to convey the correct meaning. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Reddy KS, Morya AK, Gaur A, Varatharajan S. Importance of etiologies of secondary diabetes: How often do we think off in clinical practice? <em>World J Clin Cases</em> 2025; 13(5): 95879 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 16 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i5/101306.htm" class="author-comment" target="_blank"> "1. Title does not mention the article type. Suggested to include the nature of the manuscript as descriptive review 2. Are the ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i5/101306.htm" target="_blank" class="author-comment"> "1. Title does not mention the article type. Suggested to include the nature of the manuscript as descriptive review 2. Are the expenditure involved in setting up and training included in the discussion? A short review about the cost / training issues involved can be added 3. Conclusion can be brief with a preceding summary to include the overall sum up." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Abdalla MMI, Mohanraj J. Revolutionizing diabetic retinopathy screening and management: The role of artificial intelligence and machine learning. <em>World J Clin Cases</em> 2025; 13(5): 101306 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 17 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2220-315x/full/v14/i4/98005.htm" class="author-comment" target="_blank"> "The work is very interesting and very useful. The introduction is rather short, I would have expanded with some details on the ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2220-315x/full/v14/i4/98005.htm" target="_blank" class="author-comment"> "The work is very interesting and very useful. The introduction is rather short, I would have expanded with some details on the prevalence values and geographical distribution. A "Material and Methods" session is missing. Although narrative as a review, it is important to at least declare the keywords used and search engines. The Results are well described and the table is quite clear. I would have added some graphs to clarify the percentages and prevalence of maxillary and mandibular bone lesions in these syndromes. The literature cited is relevant and recent." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Schuch LF, Silveira FM, Pereira-Prado V, Sicco E, Pandiar D, Villarroel-Dorrego M, Bologna-Molina R. Clinicopathological and molecular insights into odontogenic tumors associated with syndromes: A comprehensive review. <em>World J Exp Med</em> 2024; 14(4): 98005 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 18 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i11/1056.htm" class="author-comment" target="_blank"> "**Review Comments** This study explores the effects of mesenchymal stem cells (MSCs) and hyaluronic acid (HA) on inflammatory ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i11/1056.htm" target="_blank" class="author-comment"> "**Review Comments** This study explores the effects of mesenchymal stem cells (MSCs) and hyaluronic acid (HA) on inflammatory markers and antioxidant defense mechanisms in experimental osteoarthritis (OA). The findings indicate that BMMSCs and HA exhibit significant anti-inflammatory, antioxidative, and anti-arthritic effects in Wistar rats with monosodium iodoacetate (MIA)-induced OA. While the results highlight the therapeutic potential of BMMSCs and HA in OA management, the study lacks experimental evidence elucidating the specific pathways or mechanisms through which these agents confer their protective effects against MIA-induced OA. Addressing this gap would substantially enhance the scientific depth of the manuscript. To strengthen the study's impact and provide continuity for future research, I suggest the following: 1. **Investigation of Cellular and Molecular Mechanisms**: Incorporating data on the signaling pathways or molecular mechanisms involved in the protective effects of BMMSCs and HA would be invaluable. For instance, exploring their roles in modulating inflammatory cytokines, oxidative stress pathways, or cartilage regeneration processes could offer greater insight into the underlying biology. 2. **Extension of Experimental Design**: In future experiments, the authors could consider validating their findings with additional assays, such as gene expression profiling, protein analysis, or pathway inhibition studies. This would not only reinforce the study's conclusions but also provide a foundation for potential therapeutic applications of BMMSCs and HA in OA treatment. By addressing these aspects, the manuscript would offer a more comprehensive understanding of the mechanisms of action and further solidify its contributions to the field of osteoarthritis research." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Hagag UI, Halfaya FM, Al-Muzafar HM, Al-Jameel SS, Amin KA, Abou El-Kheir W, Mahdi EA, Hassan GANR, Ahmed OM. Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis. <em>World J Orthop</em> 2024; 15(11): 1056-1074 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 19 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i11/1075.htm" class="author-comment" target="_blank"> "**Review Comments** This study investigates the effects of local administration of melatonin at various concentrations, either ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i11/1075.htm" target="_blank" class="author-comment"> "**Review Comments** This study investigates the effects of local administration of melatonin at various concentrations, either alone or in combination with recombinant human bone morphogenetic protein-2 (rhBMP-2), on enhancing bone regeneration in surgically induced defects. The authors demonstrate that the combination of melatonin (1 μg) with rhBMP-2 (5 μg) exhibits a measurable impact on bone repair in critical-sized cranial defects in rats, primarily through guided bone regeneration mechanisms. The use of animal models to test the proposed hypothesis provides valuable insights into the potential therapeutic applications of melatonin in bone defect repair. To further enhance the scientific rigor and impact of the manuscript, the following suggestions are offered: 1. **Incorporation of Histological or Cellular and Molecular Biology Evidence**: While the study presents the group differences using statistical graphs, incorporating representative histological images or molecular biology data would significantly enrich the discussion. Such visual evidence would provide a clearer understanding of the mechanisms underlying bone regeneration and validate the experimental findings more robustly. 2. **Elaboration on Mechanistic Insights**: Beyond statistical comparisons, a deeper exploration of the cellular pathways and molecular mechanisms through which melatonin and rhBMP-2 synergistically promote bone healing would elevate the manuscript’s academic value. For instance, highlighting their effects on osteoblast differentiation, angiogenesis, or inflammatory modulation could add a more comprehensive perspective. By addressing these points, the manuscript could provide a more thorough and impactful contribution to the field of bone defect repair and regenerative medicine." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Paulini MR, Montarele LF, Pitol DL, Giannocco G, Pereira BF, Buchaim DV, Reis CHB, Buchaim RL, Mardegan Issa JP. Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling. <em>World J Orthop</em> 2024; 15(11): 1075-1087 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 20 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i11/1001.htm" class="author-comment" target="_blank"> "**Review Comments** This manuscript primarily provides a comprehensive review focusing on the application of adipose-derived ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i11/1001.htm" target="_blank" class="author-comment"> "**Review Comments** This manuscript primarily provides a comprehensive review focusing on the application of adipose-derived stem cells (ADSCs) in the treatment of knee osteoarthritis (KOA). The authors effectively highlight the advantages of ADSCs over bone marrow-derived mesenchymal stem cells (BMSCs), such as their higher yield in adipose tissue and ease of extraction. Overall, the manuscript is well-structured, and the inclusion of the abstract figure enhances readability for a broader audience. However, to further strengthen the manuscript and improve its impact, I recommend the following recommendations: 1. **Detailed Discussion on Molecular Mechanisms**: While the authors present the general advantages of ADSCs, the review would significantly benefit from a more in-depth discussion of the specific molecular mechanisms through which ADSCs exert therapeutic effects in KOA. This could include signaling pathways, cytokine interactions, and their role in cartilage regeneration or inflammation modulation. Providing such details would not only increase the article's scientific rigor but also broaden its appeal to researchers seeking to understand the translational potential of ADSCs. 2. **Addressing Limitations of ADSC Therapy**: The manuscript underrepresents the limitations and challenges associated with ADSC-based treatments for KOA. A more thorough discussion of issues such as potential risks, variability in therapeutic outcomes, regulatory hurdles, and the lack of large-scale clinical validation would enrich the review. Addressing these aspects is crucial, as overcoming these limitations could pave the way for more significant advancements and applications of ADSC therapy in the future. Incorporating these suggestions will enhance the manuscript's scientific depth and ensure it serves as a valuable resource for researchers and clinicians in the field." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> de Sousa EB, Gabbi Filho JPA, Gameiro VS, Baptista LS. Adipose-derived stem cells and knee osteoarthritis: New perspectives, old concerns. <em>World J Orthop</em> 2024; 15(11): 1001-1006 </div> </div> </div> <div class="more"> <span>14995 items</span>  <a href="https://www.f6publishing.com/ArticleQualityTrackings" target="_blank">Read more >></a> </div> </div> </div> <div class="mnavbar"> <div> Peer-Reviewers and Manuscript Statistics </div> </div> <div class="mnavbox"> <div class="reviewstat cl"> <dl> <dt>Editorial board members</dt> <dd><a 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Beyond statistical significance: Embracing minimal clinically important difference for better patient care. <i><i>World J Methodol</i></i> 2025; 15(1): 97814</p> </a> </div> <div class="count"> 2025-03-20 | Browse: 1570 | Download: 186 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 6 </div> <div class="item fl"> <div class="title"> <a href="/2222-0682/full/v15/i1/97512.htm" target="_blank"> <p>Fatakhova K, Inayat F, Ali H, Patel P, Rehman AU, Afzal A, Sarfraz M, Sarfraz S, Nawaz G, Chaudhry A, Dhillon R, Dilibe A, Glazebnik B, Jones L, Glazer E. Gender disparities and woman-specific trends in Barrett’s esophagus in the United States: An 11-year nationwide population-based study. <i><i>World J Methodol</i></i> 2025; 15(1): 97512</p> </a> </div> <div class="count"> 2025-03-20 | Browse: 2663 | Download: 199 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 7 </div> <div class="item fl"> <div class="title"> <a href="/2222-0682/full/v15/i1/97374.htm" target="_blank"> <p>Deniz HA, Polat Balkan E, İncebeyaz B, Kamburoğlu K. Evaluation of the effect of gamification applications on the success of dentistry students. <i><i>World J Methodol</i></i> 2025; 15(1): 97374</p> </a> </div> <div class="count"> 2025-03-20 | Browse: 2246 | Download: 282 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 8 </div> <div class="item fl"> <div class="title"> <a href="/2222-0682/full/v15/i1/97171.htm" target="_blank"> <p>Prakash S, Vadodaria V, Chawda N, Shah CS, Prakash A. 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Reevaluating health metrics: Unraveling the limitations of disability-adjusted life years as an indicator in disease burden assessment. <i><i>World J Methodol</i></i> 2025; 15(1): 95796</p> </a> </div> <div class="count"> 2025-03-20 | Browse: 1434 | Download: 180 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 13 </div> <div class="item fl"> <div class="title"> <a href="/2222-0682/full/v15/i1/94833.htm" target="_blank"> <p>Jeyaraman M, Jeyaraman N, Ramasubramanian S, Balaji S. Navigating the ethical terrain: Off-label and experimental treatments in medical case reports. <i><i>World J Methodol</i></i> 2025; 15(1): 94833</p> </a> </div> <div class="count"> 2025-03-20 | Browse: 1240 | Download: 172 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 14 </div> <div class="item fl"> <div class="title"> <a href="/2222-0682/full/v15/i1/92943.htm" target="_blank"> <p>Stifter S, McCaffrey J, Nichols T, Ozcan Edeer A, Ward J. 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Expanding role of antibodies in kidney transplantation. <i><i>World J Transplant</i></i> 2025; 15(1): 99220</p> </a> </div> <div class="count"> 2025-03-18 | Browse: 86 | Download: 19 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 20 </div> <div class="item fl"> <div class="title"> <a href="/2220-3230/full/v15/i1/99004.htm" target="_blank"> <p>Garas MG, Calzadilla-Bertot L, Smith BW, Delriviere L, Jaques B, Mou L, Adams LA, MacQuillan GC, Garas G, Jeffrey GP, Wallace MC. 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onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v13/i6/100673.htm" class="author-comment" target="_blank"> "since the patient also had general anesthesia, it should be clairifed to whihc degree analgesics given for the procedure prevented the patient from experienceing severe pain xxxx xx x x x x x x x x x x x x x x x x x x x x x x xx x x x x x xx " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Chen KH, Kang MY, Chang YT, Huang SY, Wu YS. Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report. <em>World J Clin Cases</em> 2025; 13(6): 100673 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 2 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2285.htm" class="author-comment" target="_blank"> "The novelty of the topic is very important, suitable for fine rather than too broad content. The interpretation of statistical results ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i12/2285.htm" class="author-comment" target="_blank"> "The novelty of the topic is very important, suitable for fine rather than too broad content. The interpretation of statistical results needs to be rigorous, correlation does not mean causation, and the HR presented may be inaccurate. The discussion needs to be tightly focused on the results and not extend to other unwarranted conclusions. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Chen DQ, Wu YX, Zhang YX, Yang HL, Huang HH, Lv JY, Xiao Q. Sarcopenia-associated factors and their bone mineral density levels in middle-aged and elderly male type 2 diabetes patients. <em>World J Diabetes</em> 2024; 15(12): 2285-2292 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 3 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4969.htm" class="author-comment" target="_blank"> "I would like to commend the authors for their comprehensive analysis of the complex interplay between gut microbiota, mesenteric ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i46/4969.htm" class="author-comment" target="_blank"> "I would like to commend the authors for their comprehensive analysis of the complex interplay between gut microbiota, mesenteric adipose tissue (MAT), and creeping fat (CF) in the context of Crohn’s disease (CD). The manuscript provides a valuable contribution to the field. The article meticulously elucidates the profound clinical significance of the interplay between the gut microbiota and MAT/CF. The authors have not only reviewed the current body of knowledge but have also contributed novel insights into the role of MAT and CF in shaping CD phenotypes and treatment strategies.The structure of the letter is well-organized, making it easy to follow the authors' line of reasoning. The abstract succinctly captures the essence of the study, and the core tip effectively highlights the main takeaways for the reader.The exploration of fecal microbiota transplantation (FMT) as a therapeutic strategy is both timely and relevant. The authors have successfully linked the current understanding of microbial imbalances to potential clinical applications, which could influence future treatment protocols for CD. In conclusion, Hasnaoui et al. have provided a thought-provoking analysis of the role of gut microbiota and MAT/CF in CD. Their work not only advances our understanding of the disease but also offers promising avenues for therapeutic intervention. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Hasnaoui A, Trigui R, Giuffrida M. Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease. <em>World J Gastroenterol</em> 2024; 30(46): 4969-4976 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 4 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i45/4836.htm" class="author-comment" target="_blank"> "The author suggests to use in all diabetic patients an interesting technique, the” body surface gastric mapping” (BSGM), to detect ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i45/4836.htm" class="author-comment" target="_blank"> "The author suggests to use in all diabetic patients an interesting technique, the” body surface gastric mapping” (BSGM), to detect the onset of gastric dysmotility precursor of gastroparesis, instead of invasive procedures, as gastroscopy, manometry, emptying of radiopaque markers or radioactive bolus and breath tests . The idea is interesting , but there are some observations to make. First of all the author forgot a simple, not invasive, physiologic and reliable method to measure gastric emptying, that is real-time ultrasonography, which allows the use of a normal solid–liquid meal and gives an immediate result (1). Furthermore the author did not take into account the fact that, as indicated in figure 1 of ref. 4, the cause of delayed gastric emptying in gastroparesis may be also due, not only to antral dysmotility detectable with BSGM, but also to impaired pyloric relaxation upon arrival of antral peristalsis (pylorospasm) and, sometimes, to dysmotility of duodenum, which does not accept the bolus coming from the stomach. The pylorospasm, which was observed in 14 of 24 diabetics, by Mearin et al (2) forms part of the widespread disruption of gut motility that affects some patients with diabetes. Unfortunately these pyloric and duodenal motor abnormalities are not detected by the technique of BSGM, which could find a normal antral motility, giving the impression that everything is OK, while the gastric emptying is already delayed. Therefore I would suggest to monitor the diabetic patients with the real-time ultrasonography, which is able to detect also a minimal delay in gastric emptying harbinger of gastroparesis, and, if the gastric emptying is delayed, then perform the BSGM, to see if the cause of the slowing is due to antral dysmotility. If the latter examination is negative, then the cause of delayed gastric emptying shoul be pylorospasm or duodenal dysmotility. REFERENCES 1) Bolondi L, Bortolotti M, Santi V, Calletti T, Gaiani S, Labò G. Measurement of gastric emptying time by real-time ultrasonography. Gastroenterology. 1985 Oct; 89(4):752-9.PMID:3896910. 2) Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology. 1986 Jun;90(6):1919-25. doi: 10.1016/0016-5085(86)90262-3. PMID: 3699409 " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Mori H. Early detection and intervention in diabetic gastroparesis: Role of body surface gastric mapping. <em>World J Gastroenterol</em> 2024; 30(45): 4836-4838 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 5 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-5190/full/v16/i11/617.htm" class="author-comment" target="_blank"> "This article presents a case report of air embolism occurring during endoscopic retrograde cholangiopancreatography (ERCP), ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-5190/full/v16/i11/617.htm" class="author-comment" target="_blank"> "This article presents a case report of air embolism occurring during endoscopic retrograde cholangiopancreatography (ERCP), emphasizing the necessity for gastroenterologists to maintain a high level of vigilance regarding this potential complication during such procedures. While ERCP is a widely used and effective diagnostic and therapeutic technique, air embolism represents a serious complication that can significantly jeopardize patient health. Consequently, this article not only reviews pertinent cases and analyzes the mechanisms, clinical manifestations, and countermeasures associated with air embolism but also underscores the importance of preventive measures that medical staff should implement to minimize the incidence of such complications during ERCP. The aim of this article is to provide a comprehensive overview of relevant knowledge, thereby enabling medical professionals to better understand and address this issue, ultimately enhancing the safety and effectiveness of clinical operations. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Li JH, Luo ZK, Zhang Y, Lu TT, Deng Y, Shu RT, Yu H. Systemic air embolism associated with endoscopic retrograde cholangiopancreatography: A case report. <em>World J Gastrointest Endosc</em> 2024; 16(11): 617-622 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 6 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i11/2203.htm" class="author-comment" target="_blank"> "Exercise during pregnancy improve organ development in offspring with gestational diabetes mellitus Shengju Chen, Hangming Fan, Yu ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i11/2203.htm" class="author-comment" target="_blank"> "Exercise during pregnancy improve organ development in offspring with gestational diabetes mellitus Shengju Chen, Hangming Fan, Yu Chen Abstract In this commentary, we discuss the study by Tang et al., “Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus”. Gestational diabetes mellitus (GDM), defined as ‘glucose intolerance with onset or first recognition during pregnancy’, impacts millions of women worldwide and poses significant health risks. Exercise during pregnancy has been shown to improve offspring health outcomes in obese mothers, potentially reducing epigenetic changes associated with maternal high-fat diets and minimizing abnormalities in lipid and glucose metabolism. However, while prenatal exercise’s impact on metabolic disorders in GDM offspring has been explored, its effects on organ growth remain insufficiently understood. Tang et al. identified GLUT1 and HIF1 as key regulators influencing the development of the heart, liver, and kidney in GDM offspring. Their study demonstrates that exercise during pregnancy supports organ development by inhibiting placental GLUT1 and HIF1 expression in GDM. This work contributes to understanding the role of GLUT1 and HIF1 in moderating the effects of prenatal exercise on organ development in GDM-affected offspring, supporting the idea that maternal exercise is an important intervention for improving offspring outcomes in GDM pregnancies and warrants further investigation in future epigenetic research. Introduction Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, affecting approximately 20.9 million pregnant women and their newborns worldwide as of 2020. GDM is associated with a range of adverse pregnancy outcomes, including preeclampsia, polyhydramnios, and fetal organomegaly (Pettitt et al., 1980). Additionally, GDM poses several short-term risks to offspring, such as neonatal respiratory distress, metabolic complications (Ferrara et al., 2007), and increased perinatal mortality rates. The GDM quintet management model recommends five core interventions to mitigate these risks, exercise, dietary regulation, maternal education, pharmacological treatment, and fetal health evaluation (Association, 2003). Pathophysiologically, GDM is characterized by hyperglycemia, glucose intolerance, and insulin resistance, typically manifesting in the late second to early third trimester of pregnancy (Buchanan et al., 2012, Jovanovic and Pettitt, 2001, Pereira et al., 2015). Several mechanisms have been proposed to explain these outcomes, including chronic fetal hyperinsulinemia, impaired oxygenation due to elevated metabolic rates, and metabolic acidosis (Freinkel, 1980). In this commentary, we discuss the article by Tang et al., recently published in the recent issue of the World Journal of Diabetes, which explores the impact of maternal exercise during pregnancy on organ development in offspring of mothers with GDM. Risks and complications associated with GDM In a healthy pregnancy, insulin sensitivity decreases to allow more glucose availability for the fetus; however, normoglycemia is typically maintained through increased insulin production by pancreatic β-cells. In cases of GDM, the pancreas may fail to produce sufficient insulin, resulting in elevated blood glucose levels and the onset of GDM (Freinkel, 1980). GDM pregnancies can lead to additional complications that negatively impact maternal and fetal health (Poston et al., 2011). Immediate complications in offspring of overweight women with GDM include macrosomia, the most severe of which is shoulder dystocia; other neonatal complications such as hypoglycemia and hyperbilirubinemia have also been reported (Kaaja and Rönnemaa, 2008, Lecomte et al., 2017). Long-term exposure to GDM increases the risk of obesity, type 2 diabetes, and cardiovascular diseases (CVD) as offspring age (Capobianco et al., 2016). Epigenetic studies indicate that the intrauterine environment significantly influences offspring organ development, and exposure to elevated maternal blood levels can impair fetal health. Maintaining a healthy uterine environment is thus essential to promoting favorable health outcomes in offspring. Exercise, as a non-pharmacological intervention without side effects, is widely used in diabetes prevention and management. Given that pregnancy is a period when non-pharmacological interventions are especially favored by medical staff and patients, exercise is particularly promising for managing GDM. Benefits of exercise during pregnancy Eight national guidelines on exercise during pregnancy recommend 60-150 minutes of aerobic exercise per week for healthy pregnant women (Savvaki et al., 2018). The benefits of exercise for pregnant women include improved overall health, better weight management, reduced risk of GDM and gestational hypertension (Davenport et al., 2018, Yu et al., 2018). For women with GDM, moderate aerobic or combined exercise has been shown to enhance postprandial blood glucose control (Walter and Klaus, 2014), although the optimal duration and intensity remain unclear. Moderate exercise during pregnancy can improve maternal insulin sensitivity, reduce placental lipid accumulation in both male and female fetuses, and alleviate hypoxia, positively influencing the intrauterine environment and fetal growth (Laker et al., 2014). Exercise during pregnancy also promotes healthier liver glucose production, helps maintain liver triglycerides levels, and prevents the expression of liver enzymes and genes in offspring caused by maternal high-fat diet, thereby improving the offspring’s metabolic profile. These findings suggest that maternal exercise can mitigate modifications linked to a high-fat diet, protecting offspring from future metabolic diseases. Regulation of GLUT1 by maternal exercise and offspring health outcomes in GDM The placenta is responsible for transporting essential nutrients and oxygen from maternal to fetal circulation, as fetal gluconeogenesis is minimal (Kalhan and Parimi, 2000). GDM disrupts placental function, leading to various morphological (Treesh and Khair, 2015) and vascular changes (Aldahmash et al., 2022, El Sawy et al., 2018) and including fetal vascular changes and DNA methylation (Song et al., 2022). Placental transport proteins, such as glucose transporters, facilitate nutrient transfer from the mother to the fetus. Glucose is the primary energy source for both placental and fetal growth (Stanirowski et al., 2017), with GLUT1 and GLUT3 serving as the main placental glucose transport proteins in humans. GLUT1 is expressed in syncytiotrophoblast microvilli and the basal membrane, as well as in vascular endothelium and cell layers (Brown et al., 2011, Jansson et al., 1993). Research on GDM in humans and mice shows increased placental GLUT1 expression, likely due to increased glucose availability in maternal circulation, which enhances placental glucose consumption (Muralimanoharan et al., 2016). This increase in GLUT1 may contribute to the higher rates of macrosomia observed in GDM pregnancies (Stanirowski et al., 2022). Moreover, GDM leads to placental hypoxia, elevated hypoxia-inducible (HIF) levels, and glial cell missing 1 degradation, inhibiting trophoblast migration and invasion. Exercise during pregnancy can significantly reduce placental GLUT1 expression and alleviate hypoxia. Silencing GLUT1 can partially counteract the reduced trophoblast migration caused by hyperglycemia and hypoxia. Beyond energy metabolism, GLUT1 is also related to the development of the heart, liver, and kidneys. Zhang et al. investigated the relationship between GLUT1 expression in these organs and their structural and pathological changes, examining how exercise influences growth and development in offspring with GDM. In a neonatal GLUT1 transgenic heart model, increased glucose metabolism can stimulate hyperplastic growth after cardiac injury (Fajardo et al., 2021). Maternal exercise during pregnancy has been shown to lower hepatic GLUT1 expression, reduce inflammatory infiltration, and decrease the risk of liver disease in adult offspring (Baker and Friedman, 2018). In the kidney, GLUT1 functions vary by cell type; elevated GLUT1 in mesangial cells can impair kidney structure, while in podocytes, it may reduce mesangial expansion and fibronectin accumulation (Chen et al., 2024). Future research is recommended to clarify the specific mechanisms by which exercise benefits renal structure and function in GDM offspring. Directions for future studies The specific mechanisms by which maternal exercise during pregnancy improves health outcomes in diabetic offspring remain under investigation, with multiple synergistic pathways likely involved. Given its role in glucose metabolism, GLUT1 is of particular interest as a regulatory factor in mitigating adverse outcomes in offspring of mothers with GDM through exercise. This underscores the significant influence of exercise on glucose metabolism, which enhances the intrauterine environment and supports offspring health. Improved placental GLUT1 expression appears to regulate the GLUT1 levels in offspring organs, positively impacting organ development. These findings extend our understanding of exercise-related epigenetics modifications, yet further research is essential to clarify the pathways through which maternal exercise regulates placental GLUT1, thereby promoting healthy organ development in offspring and underscoring the benefits of prenatal exercise. Conclusion GDM can lead to adverse outcomes for both the mother and their offspring. Maternal exercise during pregnancy improves the intrauterine environment and enhances offspring health. Elevated maternal blood glucose can cause fetal hyperinsulinemia, hypoxia, and metabolic acidosis. Exercise enhances glucose metabolism, reduces high blood sugar levels, and supports a healthier intrauterine environment, thereby decreasing the risk of metabolic diseases in offspring. The study by Tang et al. confirms the association between elevated placental GLUT1 expression in GDM and abnormal offspring organ development related to hypoxia. Their research demonstrates that exercise during pregnancy can improve placental glucose transport and reduce hypoxia, mitigating adverse developmental outcomes in offspring organs at various stages. These findings validate, across human, animal, and cellular models, the molecular mechanisms through which maternal exercise enhances organ development in offspring affected by GDM. This contributes to clinical application and emphasizes the role of epigenetics in promoting offspring health. As research in epigenetic progresses, the pathways through exercise benefits GDM-affected offspring will become clearer, with GLUT1 as a central regulator of glucose metabolism. Further investigation into these mechanisms will advance our understanding of how maternal exercise supports healthier outcomes for GDM offspring. Aldahmash, W.M., Alwasel, S.H., Aljerian, K., 2022. Gestational diabetes mellitus induces placental vasculopathies. Environ Sci Pollut Res Int 29 (13), 19860-19868. Association, A.D., 2003. Gestational diabetes mellitus. Diabetes Care 26 Suppl 1, S103-105. Baker, P.R., 2nd, Friedman, J.E., 2018. Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. J Clin Invest 128 (9), 3692-3703. Brown, K., Heller, D.S., Zamudio, S., Illsley, N.P., 2011. Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation. Placenta 32 (12), 1041-1049. Buchanan, T.A., Xiang, A.H., Page, K.A., 2012. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol 8 (11), 639-649. Capobianco, E., Fornes, D., Linenberg, I., Powell, T.L., Jansson, T., Jawerbaum, A., 2016. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol 422, 221-232. Chen, Y., Bai, X., Chen, J., Huang, M., Hong, Q., Ouyang, Q., Sun, X., Zhang, Y., Liu, J., Wang, X., Wu, L., Chen, X., 2024. Pyruvate kinase M2 regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease. Cell Prolif 57 (2), e13548. Davenport, M.H., Ruchat, S.M., Poitras, V.J., Jaramillo Garcia, A., Gray, C.E., Barrowman, N., Skow, R.J., Meah, V.L., Riske, L., Sobierajski, F., James, M., Kathol, A.J., Nuspl, M., Marchand, A.A., Nagpal, T.S., Slater, L.G., Weeks, A., Adamo, K.B., Davies, G.A., Barakat, R., Mottola, M.F., 2018. Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis. Br J Sports Med 52 (21), 1367-1375. El Sawy, N.A., Iqbal, M.S., Alkushi, A.G., EL Sawy, N., Iqbal, M., Alkushi, A., 2018. Histomorphological study of placenta in gestational diabetes mellitus. Int. J. Morphol 36 (2), 687-692. Fajardo, V.M., Feng, I., Chen, B.Y., Perez-Ramirez, C.A., Shi, B., Clark, P., Tian, R., Lien, C.L., Pellegrini, M., Christofk, H., Nakano, H., Nakano, A., 2021. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep 11 (1), 8669. Ferrara, A., Weiss, N.S., Hedderson, M.M., Quesenberry, C.P., Jr., Selby, J.V., Ergas, I.J., Peng, T., Escobar, G.J., Pettitt, D.J., Sacks, D.A., 2007. Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia. Diabetologia 50 (2), 298-306. Freinkel, N., 1980. Banting Lecture 1980. Of pregnancy and progeny. Diabetes 29 (12), 1023-1035. Jansson, T., Wennergren, M., Illsley, N.P., 1993. Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. J Clin Endocrinol Metab 77 (6), 1554-1562. Jovanovic, L., Pettitt, D.J., 2001. Gestational diabetes mellitus. Jama 286 (20), 2516-2518. Kaaja, R., Rönnemaa, T., 2008. Gestational diabetes: pathogenesis and consequences to mother and offspring. Rev Diabet Stud 5 (4), 194-202. Kalhan, S., Parimi, P., 2000. Gluconeogenesis in the fetus and neonate. Semin Perinatol 24 (2), 94-106. Laker, R.C., Lillard, T.S., Okutsu, M., Zhang, M., Hoehn, K.L., Connelly, J.J., Yan, Z., 2014. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes 63 (5), 1605-1611. Lecomte, V., Maloney, C.A., Wang, K.W., Morris, M.J., 2017. Effects of paternal obesity on growth and adiposity of male rat offspring. Am J Physiol Endocrinol Metab 312 (2), E117-e125. Muralimanoharan, S., Maloyan, A., Myatt, L., 2016. Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus: role of miR-143. Clin Sci (Lond) 130 (11), 931-941. Pereira, T.J., Moyce, B.L., Kereliuk, S.M., Dolinsky, V.W., 2015. Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence. Biochem Cell Biol 93 (5), 438-451. Pettitt, D.J., Knowler, W.C., Baird, H.R., Bennett, P.H., 1980. Gestational diabetes: infant and maternal complications of pregnancy in relation to third-trimester glucose tolerance in the Pima Indians. Diabetes Care 3 (3), 458-464. Poston, L., Harthoorn, L.F., Van Der Beek, E.M., 2011. Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement. Pediatr Res 69 (2), 175-180. Savvaki, D., Taousani, E., Goulis, D.G., Tsirou, E., Voziki, E., Douda, H., Nikolettos, N., Tokmakidis, S.P., 2018. Guidelines for exercise during normal pregnancy and gestational diabetes: a review of international recommendations. Hormones (Athens) 17 (4), 521-529. Song, J.Y., Lee, K.E., Byeon, E.J., Choi, J., Kim, S.J., Shin, J.E., 2022. Maternal Gestational Diabetes Influences DNA Methylation in the Serotonin System in the Human Placenta. Life (Basel) 12 (11). Stanirowski, P.J., Szukiewicz, D., Majewska, A., Wątroba, M., Pyzlak, M., Bomba-Opoń, D., Wielgoś, M., 2022. Placental expression of glucose transporters GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in pregnancies complicated by gestational and type 1 diabetes mellitus. J Diabetes Investig 13 (3), 560-570. Stanirowski, P.J., Szukiewicz, D., Pyzlak, M., Abdalla, N., Sawicki, W., Cendrowski, K., 2017. Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 in human term placenta. Endocrine 55 (3), 799-808. Treesh, S.A., Khair, N.S.B., 2015. Histological Changes of the Human Placenta in Pregnancies Complicated with Diabetes. Journal of Cytology and Histology 6, 1-7. Walter, I., Klaus, S., 2014. Maternal high-fat diet consumption impairs exercise performance in offspring. J Nutr Sci 3, e61. Yu, Y., Xie, R., Shen, C., Shu, L., 2018. Effect of exercise during pregnancy to prevent gestational diabetes mellitus: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 31 (12), 1632-1637. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Tang YB, Wang LS, Wu YH, Zhang LX, Hu LY, Wu Q, Zhou ML, Liang ZX. Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus. <em>World J Diabetes</em> 2024; 15(11): 2203-2219 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 7 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-5190/full/v16/i11/587.htm" class="author-comment" target="_blank"> "I would love to congratulate the authors for writing this excellent editorial about malignant gastric outlet obstruction. The authors ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-5190/full/v16/i11/587.htm" class="author-comment" target="_blank"> "I would love to congratulate the authors for writing this excellent editorial about malignant gastric outlet obstruction. The authors have given an overview of the changing spectrum of therapeutic modalities from surgery to endoscopic stenting to the latest EUS-guided interventions. There was an enlightening discussion about the potential benefit of stomach-partitioning gastrojejunostomy to reduce the rate of delayed gastric emptying. The authors have rightly advocated the need for a holistic approach to treat patients with malignant gastric outlet obstructions, keeping in mind their nutritional and clinical status. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Jiang L, Chen XP. Treatment of choice for malignant gastric outlet obstruction: More than clearing the road. <em>World J Gastrointest Endosc</em> 2024; 16(11): 587-594 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 8 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-5190/full/v16/i11/617.htm" class="author-comment" target="_blank"> "I would like to congratulate the authors for reporting a rare but potentially treatable complication of ERCP. The authors have clearly ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-5190/full/v16/i11/617.htm" class="author-comment" target="_blank"> "I would like to congratulate the authors for reporting a rare but potentially treatable complication of ERCP. The authors have clearly stated the scenarios when air embolism should be suspected in a patient undergoing ERCP. The authors have beautifully shown the relevant images showing air embolism. They have also discussed in detail about the timing and efficacy of hyperbaric oxygen therapy for such patients. As GI endoscopists doing regular ERCP, we should be aware of all the potential complications of ERCP, their manifestations, how to diagnose them early and the readily available treatment modalities and availability. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Li JH, Luo ZK, Zhang Y, Lu TT, Deng Y, Shu RT, Yu H. Systemic air embolism associated with endoscopic retrograde cholangiopancreatography: A case report. <em>World J Gastrointest Endosc</em> 2024; 16(11): 617-622 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 9 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i10/1573.htm" class="author-comment" target="_blank"> "Re-evaluating the clinical impact of functional regulatory variants Ying Ming, Yun-Ling Du, Meng-Na Zhang Ying Ming, Molecular ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2220-3206/full/v14/i10/1573.htm" class="author-comment" target="_blank"> "Re-evaluating the clinical impact of functional regulatory variants Ying Ming, Yun-Ling Du, Meng-Na Zhang Ying Ming, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Yun-Ling Du, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Meng-Na Zhang, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Meng-Na Zhang, Hebei Key Laboratory of Panvascular Diseases, Chengde, 067000, China ORCID number: Ying Ming (0009-0006-2161-8207) , Yun-Ling Du (0000-0001-7624-3226) , Meng-Na Zhang (0000-0001-7624-3226) Author contributions: Ying Ming contributed to the initial drafting of the work; Yun-Ling Du contributed to the drafting process; Meng-Na Zhang contributed to the initial drafting and provided overall supervision to the drafting process; All authors have read and approved the final version of the manuscript. Conflict-of-interest statement: The authors declare that they have no conflict of interest. Corresponding author: Meng-Na Zhang, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, China zhangmengna2014@sina.com Abstract Serotonin 1A receptor polymorphism (5-HTR1A) C-1019G polymorphism (rs6295) is a functional regulatory variants reported to be related with multiple phenotypes including major depression, suicidal behavior and antidepressant response. However, clinical studies investigating this variant and its potential phenotypes had incongruous findings. Molecular studies on this variant showed it does regulate HTR1A expression but meta-analysis showed it had negative relationship with antidepressant drug response in major depressive disorder (MDD), as reported by Wu et al. in the lasted issue of the World Journal of Psychiatry. This suggested the importance of re-evaluating the clinical impact of functional regulatory variants. Key words: regulatory variants, snp-meta, snp-phenotype association Core Tip: Functional regulatory variants might have negative relationship with putative phenotypes even it do regulate gene expression. Single nucleotide polymorphism (SNP) meta analysis helps to identify a more robust SNP-phenotype relationship. We carefully read the article titled “Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis” published in the World Journal of Psychiatry by Wu et al.[1]. In this study the authors reviewed 11 clinical studies about serotonin 1A receptor polymorphism (5-HTR1A) C-1019G polymorphism (rs6295) and antidepressant response. Though reported to be related with major depression[2], suicidal behavior[3] and antidepressant response[4], rs6295 did not show significant association with antidepressant drug response in major depressive disorder (MDD) in this meta-analysis. Genome-wide association studies (GWAS) show to be a useful tool to investigate the effect of polymorphism on clinical phenotypes. Most disease-associated variants are non-coding variants. Researchers have developed multiple methods to identify functional regulatory variants from putative regulatory regions and their cis-regulated genes, like massively parallel reporter assays (MPRAs) and expression quantitative trait loci (eQTL)[5,6]. The 5-HTR1A C-1019G polymorphism (rs6295) reviewed by Wu et al. [1] is a functional upstream variant that affects HTR1A expression but not associates with antidepressant response in patients with MDD, though the 5-HT1A receptor is a primary target for most antidepressant drugs. This variant has been reported to influence HTR1A expression in numerous molecular studies. The C-allele of this variant is capable of interacting with transcription factors (TFs) such as Hes1, Hes5, and Deaf1, whereas the G-allele fails to bind these TFs [7]. Although these three TFs are typically regarded as repressors, the activity of Deaf1 at the 5-HT1A promoter exhibits opposing effects in presynaptic versus postsynaptic neuronal cells [7]. In the human prefrontal cortex, the G-allele demonstrates a lower expression level compared to the C-allele; however, this pattern does not hold true for the midbrain and hippocampus [8]. In a humanized mouse model, subjects with GG genotype exhibited higher levels of HTR1A mRNA and protein than those with CC genotype in a line-dependent manner [9]. Furthermore, in 5-HT1A-expressing neuronal cells, the G-allele was found to downregulate 5-HT1A expression [10]. These showed the complexity of regulatory variant function. Clinical researches on rs6295 had incongruous findings, raising the need for a SNP-based meta analysis. A single variant approach is a classical method to ascertain the relationship between a variant and putative phenotypes. Selective serotonin re-uptake Inhibitors (SSRIs) like fluoxetine, paroxetine, sertraline, citalopram, and fluvoxamine were included in this meta analysis, however, the result showed no significant correlation between this variation and antidepressant drug efficacy in MDD in the dominant model (CG vs CC), recessive model (GG vs CC), and combined dominant model (CG+GG vs CC). The 11 clinical studies collected in their meta analysis included multiple populations from over 10 countries with low to moderate heterogeneity and were scored 7-9 according to the Newcastle-Ottawa Scale (NOS), suggesting a result with higher confidence. The negative correlation might due to gene-gene interactions or gene-environment interactions in MDD and its treatment. A genome-wide linkage analysis for MDD showed that association of LHPP SNPs to MDD were depended on HTR1A -1019G allele [11]. Single variant approaches are limited by lower statistical detection power because most phenotypes result from the influence of many genetic variants in many genes and pathways[12]. This limitation is particularly pronounced in pharmacogenetics and multigenic diseases like MDD. Large-scale meta-analysis of GWAS might overcome this disadvantage. However, phenotype analysis involving rs6295 through GWAS is inherently limited due to its ambiguous nature (C/G). It is challenging to distinguish which complementary allele serves as the effect allele. Furthermore, the minor allele frequency (MAF) of rs6295 is G=0.483 in gnomAD and C=0.458 in 1000G, making it impossible to solve the problem by allele frequency. Ambiguous SNPs with allele frequencies close to 0.5 are usually removed in GWAS [13]. Therefore, a SNP meta-analysis remains a viable option for investigating rs6295. The clinical impacts of regulatory variants in monogenic Mendelian diseases have also been noticed. Many bioinformatic tools were developed to predict TF binding of regulatory variants like SNEEP [14]. Many of them use eQTL datasets as training and validation sets. In rs6295’s case, the variant had different functions in different brain regions, and showed negative significance to putative related phenotype. This suggested a limitation of using these tools to predict clinical candidate variants. However, there are few clinical curated regulatory variants databases available. There are only hundreds of regulatory variants in Clinvar database classified as pathogenic/likely pathogenic/benign/likely benign (data not shown). That’s not enough to feed a complex model. Overall, the negative relationship between the functional regulatory variant rs6295 and antidepressant response underscores the importance of re-evaluating the clinical significance of functional regulatory variants. Both positive and negative meta-analyses are essential for establishing robust relationships between polymorphisms and phenotypes. References [1] Wu HN, Zhu SY, Zhang LN, Shen BH, Xu LL. Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis. World J Psychiatry 2024; 14(10): 1573-1582 [2]Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci. 2003 Sep 24;23(25):8788-99 [3]Hernández-Díaz, Y., Tovilla-Zárate, C. A., Castillo-Avila, R. G., Juárez-Rojop, I. E., Genis-Mendoza, A. D., López-Narváez, M. L., Villar-Juárez, G. E., & González-Castro, T. B. (2023). Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis. European archives of psychiatry and clinical neuroscience, 273(1), 5–14 [4]Lemonde S, Du L, Bakish D, Hrdina P, Albert PR. Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. Int J Neuropsychopharmacol. 2004 Dec;7(4):501-6 [5]Abell NS, DeGorter MK, Gloudemans MJ, Greenwald E, Smith KS, He Z, Montgomery SB. Multiple causal variants underlie genetic associations in humans. Science. 2022 Mar 18;375(6586):1247-1254 [6]Umans BD, Battle A, Gilad Y. Where Are the Disease-Associated eQTLs? Trends Genet. 2021 Feb;37(2):109-124 [7]Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci. 2006 Feb 8;26(6):1864-71 [8]Donaldson ZR, le Francois B, Santos TL, Almli LM, Boldrini M, Champagne FA, Arango V, Mann JJ, Stockmeier CA, Galfalvy H, Albert PR, Ressler KJ, Hen R. The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription. Transl Psychiatry. 2016 Mar 1;6(3):e746 [9]Cunningham AM, Santos TL, Gutzeit VA, Hamilton H, Hen R, Donaldson ZR. Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model. ACS Chem Neurosci. 2019 Jul 17;10(7):3197-3206 [10]Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci. 2006 Feb 8;26(6):1864-71 [11]Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA. Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression. Mol Psychiatry. 2009 Jun;14(6):621-30 [12]Defo J, Awany D, Ramesar R. From SNP to pathway-based GWAS meta-analysis: do current meta-analysis approaches resolve power and replication in genetic association studies? Brief Bioinform. 2023 Jan 19;24(1):bbac600 [13]Ndong Sima, C.A.A., Step, K., Swart, Y. et al. Methodologies underpinning polygenic risk scores estimation: a comprehensive overview. Hum. Genet. 143, 1265–1280 (2024) [14]Baumgarten N, Rumpf L, Kessler T, Schulz MH. A statistical approach for identifying single nucleotide variants that affect transcription factor binding. iScience. 2024 Apr 18;27(5):109765 " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Wu HN, Zhu SY, Zhang LN, Shen BH, Xu LL. Association between <i>5-HTR1A</i> gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis. <em>World J Psychiatry</em> 2024; 14(10): 1573-1582 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 10 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i39/4295.htm" class="author-comment" target="_blank"> "This study provides valuable insights into the treatment of Helicobacter pylori infection. The comparison between low - dose and ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i39/4295.htm" class="author-comment" target="_blank"> "This study provides valuable insights into the treatment of Helicobacter pylori infection. The comparison between low - dose and standard - dose tetracycline in combination with amoxicillin quadruple therapy is well - designed and the results are significant.The research is comprehensive, considering factors such as eradication rates and adverse events. It offers a potential alternative treatment option with better safety profiles, which is beneficial for patients. Also, there still exist some questions to be considered. 1. Regarding the article structure • When introducing the research background, various antibiotic resistance rates against Helicobacter pylori are listed in detail. However, could this part be presented more concisely and focused more on the resistance situations of tetracycline and amoxicillin directly related to this study? • In the research methods section, could the description of the patient inclusion and exclusion criteria be more focused on the key points and avoid being interfered by too many irrelevant details? For example, the emphasis could be placed on those factors that may have a crucial impact on the research results. • In the results presentation part, could the comparison results of different groups be shown in a clearer structure? For example, the main results of all groups could be presented first, and then the situations of each subgroup (such as the primary treatment group and the rescue treatment group) could be elaborated in detail respectively, which would make it easier for readers to grasp the overall logic. 2. Regarding the article content • When discussing the advantages of low - dose tetracycline, besides comparing the eradication rates and adverse events with the standard - dose tetracycline, could the possible mechanism of action be further explored? This would help readers understand the research results more in - depth. • Some factors affecting the Helicobacter pylori eradication rate are mentioned in the article, such as patient compliance, smoking history, etc. However, could a more in - depth analysis of the interactions between these factors be carried out? For example, does smoking affect the eradication rate by influencing compliance? • Regarding the content of the gut microbiota, although it is mentioned in the limitations that the impact of the low - dose tetracycline regimen on the gut microbiota has not been studied, could the future research directions be more specifically elaborated on how to design relevant studies to explore this issue? 3. Regarding the charts • There is a lot of data in the tables in the article, and some abbreviations in the tables may confuse readers. Could more detailed explanations be given below the tables or where the abbreviations first appear? • Could the titles of the charts more clearly reflect the core content of the charts? For example, some chart titles only simply describe the variables involved in the charts without highlighting the main conclusions or trends. • Could some more charts be considered to present the key information in the research more intuitively? For example, charts could be used to show the occurrence trends of adverse events in different tetracycline dose groups during the treatment process, or to present the relative magnitudes of the impacts of different factors on the eradication rate. 4.Further study • It would be interesting to see if the results hold true in different populations and geographical regions. • The study could have included a more detailed analysis of the long - term effectiveness and potential recurrence of H. pylori infection after treatment. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Zhao YR, Wang XJ, Zhu MJ, Chen AL, Zhang D, Du Q, Kim JJ, Hu WL. Efficacy and safety of low-dose tetracycline, amoxicillin quadruple therapy in <i>Helicobacter pylori</i> infection: A retrospective single center study. <em>World J Gastroenterol</em> 2024; 30(39): 4295-4304 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 11 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-5204/full/v16/i11/4468.htm" class="author-comment" target="_blank"> "This paper conducts an in-depth study on the effects of invigorating-spleen and anticancer prescription (ISAP) in a mice model of ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-5204/full/v16/i11/4468.htm" class="author-comment" target="_blank"> "This paper conducts an in-depth study on the effects of invigorating-spleen and anticancer prescription (ISAP) in a mice model of colon cancer, providing valuable experimental data and analysis. Here are some of my comments on the paper: 1. Clear research background: The paper begins with a detailed introduction to the epidemiological data of colon cancer, emphasizing the severity of the disease and the limitations of existing treatment methods, providing a good background for the necessity of the study. 2. Reasonable experimental design: The study established a mice model of colon cancer and divided it into several experimental groups (including a control group and groups with different doses of ISAP), a design that effectively compares the effects of different doses of ISAP on tumor suppression. 3. Detailed data analysis: The paper provides detailed data on the measurement of mice weight, tumor inhibition rate, and related protein expression levels, with clear and understandable results. These data provide empirical support for the anti-tumor mechanism of ISAP. 4. In-depth mechanism exploration: By analyzing key proteins in the ERK/MAPK signaling pathway, the paper explores the potential mechanism of action of ISAP, providing new ideas for subsequent research. 5. Clinical significance: Although the study has achieved positive results in the mice model, the effectiveness and safety of ISAP still need to be verified in clinical trials. This point can be further emphasized in the discussion section. 6. Language and structure: The language of the paper is relatively fluent, with a clear structure, making it easy for readers to understand. However, the explanation of some professional terms could be more detailed, for the understanding of non-professional readers. Overall, this paper provides strong support for the potential of ISAP in the treatment of colon cancer, looking forward to seeing more clinical research results in the future. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Wang W, Wang J, Ren XX, Yue HL, Li Z. Effects of invigorating-spleen and anticancer prescription on extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in colon cancer mice model. <em>World J Gastrointest Oncol</em> 2024; 16(11): 4468-4476 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 12 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i10/873.htm" class="author-comment" target="_blank"> "The original article by Wang FD et al., "Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i10/873.htm" class="author-comment" target="_blank"> "The original article by Wang FD et al., "Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischaemia-reperfusion injury via TXNIP regulation," is very good. GABA-induced miR-21-5p-loaded EVs utilise a unique mechanism to lessen myocardial ischaemia-reperfusion injury (MIRI) and present a novel method for managing MIRI through oxidative stress modulation. The study reported that miR-21-5p exerts its effects through a direct interaction with TXNIP in cardiomyocytes, thereby triggering oxidative stress and elucidating related molecular mechanisms. Furthermore, this work systematically employs in vivo, in vitro, and a variety of imaging methods with gene knockout models to provide comprehensive methodological proofs. Considering myocardial ischaemia is a common clinical condition, this study has high translational relevance. But there are few queries: The experiment only evaluates its EV source in inguinal ADSCs and could miss other potential beneficial configurations of EV. It is still unclear whether these short-term therapeutic effects are sustainable or if they interfere with repeated dosing against MIRI, despite the study's lack of a long-term assessment. The process of producing, standardizing, and ensuring the safety of EVs for human use could potentially complicate the clinical translation of the latter strategy. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Wang FD, Ding Y, Zhou JH, Zhou E, Zhang TT, Fan YQ, He Q, Zhang ZQ, Mao CY, Zhang JF, Zhou J. Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury <i>via</i> TXNIP regulation. <em>World J Stem Cells</em> 2024; 16(10): 873-895 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 13 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i10/950.htm" class="author-comment" target="_blank"> "The theme of this article is very practical and a common problem that troubles elderly women, and the conclusion is very meaningful. ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2218-5836/full/v15/i10/950.htm" class="author-comment" target="_blank"> "The theme of this article is very practical and a common problem that troubles elderly women, and the conclusion is very meaningful. It can help alleviate the pain of many women. The abundant scientific data and clear images fully demonstrate the role of exercise therapy, providing methods and ideas for further research.As a reader, I really enjoy this article as it allows me to quickly gain knowledge about this topic. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Dai ZQ, Gong XY, Zhang R, Jin MQ, Lu W, Wen W, Chen J, Lu FJ, Yang YF, Wang L, He XJ. Research trends in exercise therapy for the treatment of pain in postmenopausal osteoporosis over the past decade: A bibliometric analysis. <em>World J Orthop</em> 2024; 15(10): 950-964 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 14 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i38/4242.htm" class="author-comment" target="_blank"> "This article is interesting, but does not provide any novelties nor scientific approaches in diagnostics of IBD, it is based on ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1007-9327/full/v30/i38/4242.htm" class="author-comment" target="_blank"> "This article is interesting, but does not provide any novelties nor scientific approaches in diagnostics of IBD, it is based on "defending" physicians and minorizing their role in detecting Crohn's disease. I could agree with main conclusion of this article, that providing a diagnose of Crohn's disease is multifactorial, and it depends not only on physicians but on patients itself, time frame, diagnostic abilities. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Zeng Y, Zhang JW, Yang J. Physician-dependent diagnosis delay in Crohn's disease: A pseudo-proposition or not? <em>World J Gastroenterol</em> 2024; 30(38): 4242-4245 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 15 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i10/2058.htm" class="author-comment" target="_blank"> "1. This study lacks an ethics statement. It is advisable to include an ethics statement within the methods section. 2. The ROC curve ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-9358/full/v15/i10/2058.htm" class="author-comment" target="_blank"> "1. This study lacks an ethics statement. It is advisable to include an ethics statement within the methods section. 2. The ROC curve presented in the results suggests that the sample size may be relatively insufficient. It is recommended that researchers increase the sample size in further studies and conduct prospective investigations to validate these findings. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Lin BS, Liu ZG, Chen DR, Yang YL, Yang DZ, Yan JH, Zeng LY, Yang XB, Xu W. Relationship between hemoglobin glycation index and risk of hypoglycemia in type 2 diabetes with time-in-range in target. <em>World J Diabetes</em> 2024; 15(10): 2058-2069 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 16 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2218-4333/full/v15/i11/1428.htm" class="author-comment" target="_blank"> "Title: A Study on the Deterioration of Intracranial Epidermoid Cysts through Whole Exome Sequencing Dear Editors and Authors, First ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2218-4333/full/v15/i11/1428.htm" class="author-comment" target="_blank"> "Title: A Study on the Deterioration of Intracranial Epidermoid Cysts through Whole Exome Sequencing Dear Editors and Authors, First and foremost, I would like to congratulate the authors on the publication of this high-quality case report on the malignant transformation of intracranial epidermoid cysts (IEC) into squamous cell carcinoma (SCC) in the "World Journal of Clinical Oncology." This study not only provides valuable insights into the molecular mechanisms underlying the transformation of IEC to SCC but also reveals two potential disease-related gene mutations: GJB2 (c.257C>T) and TLR2 (c.1039A>G) through whole exome sequencing (WES). Comment Content: Innovation and Importance of the Study: The innovation of this study lies in providing the first clinical evidence for the potential role of GJB2 and TLR2 in the development and treatment of IEC. This is significant for guiding future research directions and potential therapeutic targets. Rigorous Study Design: The authors have employed WES technology, which is efficient and cost-effective for processing large amounts of data quickly. This method is highly applicable for screening genetic variants related to rare and complex diseases, demonstrating the rigor and forward-thinking of the study design. Detailed Case Report: The article provides a very detailed description of the case, including the patient's clinical symptoms, medical history, laboratory test results, and imaging examination results. These details help readers to fully understand the case and provide valuable data for future research. In-Depth Analysis of Genetic Variants: The authors not only identified two risk variants but also conducted an in-depth analysis of their impact on protein structure and function. This in-depth analysis helps to understand how these variants affect the occurrence and development of the disease. Comprehensive Treatment and Follow-Up: The article describes the patient's treatment process and follow-up results in detail, providing valuable references for clinical doctors and demonstrating the effectiveness of comprehensive treatment in controlling the condition. Suggestions for Improvement: Increase the Sample Size: Although this is a report on a rare case, increasing the sample size will help to verify the association between these gene mutations and the deterioration of IEC and improve the generalizability and reliability of the study's results. Functional Validation Experiments: The authors mentioned plans for functional validation experiments in future studies. These experiments will help further confirm the role of GJB2 and TLR2 in the development of IEC and how these mutations affect protein function. Long-Term Follow-Up Data: Long-term follow-up data will help assess the long-term effects of treatment and the patient's quality of life, which is crucial for evaluating treatment outcomes and formulating treatment guidelines. Conclusion: This article is an important contribution to the study of the mechanisms underlying the malignant transformation of IEC. It not only enhances our understanding of the genetic basis of this rare disease but also provides new ideas for future treatments. The authors' work is commendable, and I look forward to their future research bringing more breakthrough " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Song ZN, Cheng Y, Wang DD, Li MJ, Zhao XR, Li FW, Liu Z, Zhu XR, Jia XD, Wang YF, Liang FF. Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration: A case report. <em>World J Clin Oncol</em> 2024; 15(11): 1428-1434 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 17 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2218-4333/full/v15/i11/1404.htm" class="author-comment" target="_blank"> "The combination of Astragalus polysaccharide and gimeracil oteracil potassium capsule (S-1) in the treatment of pancreatic cancer ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2218-4333/full/v15/i11/1404.htm" class="author-comment" target="_blank"> "The combination of Astragalus polysaccharide and gimeracil oteracil potassium capsule (S-1) in the treatment of pancreatic cancer can effectively improve the efficacy, reduce side effects, and increase long-term survival rates, which has significant clinical value.In the future, we can further validate its efficacy by conducting prospective, large-scale, multi-center studies and provide more guiding recommendations for clinical practice. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Li GY, Jiang J. Recent efficacy and long-term survival of <i>Astragalus</i> polysaccharide combined with gemcitabine and S-1 in pancreatic cancer. <em>World J Clin Oncol</em> 2024; 15(11): 1404-1411 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 18 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-5182/full/v16/i9/1269.htm" class="author-comment" target="_blank"> "Commentary: Predictors of survival in autoimmune liver disease overlap syndromes Jian-Guo Zhang,Biao Wen Jian-Guo Zhang,Biao ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-5182/full/v16/i9/1269.htm" class="author-comment" target="_blank"> "Commentary: Predictors of survival in autoimmune liver disease overlap syndromes Jian-Guo Zhang,Biao Wen Jian-Guo Zhang,Biao Wen,Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China Author contributions:Jian-Guo Zhang wrote the original draft; Biao Wen contributed to conceptualization, writing, reviewing and editing; Jian-Guo Zhang and Biao Wen participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. ORCID number：0000-0001-5226-5981 Corresponding author:Biao Wen,MD, PhD,Assistant Professor,Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College,No. 312, Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com We perused the article authored by Jayabalan et al[1]with considerable interest and extend our congratulations to the authors for their commendable endeavor. The authors have reported a prospective investigation into the predictors of survival in patients with autoimmune liver disease overlap syndromes (AILDOS)[1]. The study's conclusion suggests that the LOS holds potential as a predictive tool for liver-related mortality in individuals with autoimmune hepatitis and primary biliary cholangitis overlap (AIH-PBC)[1]. However, several aspects of this study merit further scrutiny and discussion. Firstly, a critical exclusion criterion for the study was the prior performance of a liver transplant prior to enrollment[1]. Upon consideration, we postulated the possibility that a portion of the enrolled patients might harbor coexisting liver pathology stemming from disparate causes (including, but not limited to, alcoholic liver disease or viral hepatitis), which could introduce bias and complicate the interpretation of our results. Therefore, we advised the authors to implement rigorous exclusion criteria for such patients to uphold the accuracy and reliability of our findings. Secondly, the diagnoses of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC) were established in accordance with the criteria stipulated by the International Autoimmune Hepatitis Group, the European Association for the Study of the Liver Clinical Practice Guidelines, and the American College of Gastroenterology Clinical Guidelines, respectively[1-4]. It is noteworthy that these diagnostic criteria originate from disparate geographical regions, and the progression of research concerning each disease varies across these regions. Consequently, such variability may potentially impact the precision of the study's findings. In light of this, we propose that the authors consider adopting diagnostic criteria from a uniform geographical region. Therefore, we recommend the uniform application of diagnostic guidelines or consensus recommendations established by reputable institutions in the United States for the purposes of disease ascertainment. Such standardization is poised to substantially elevate the reliability and validity of the research findings, thereby reinforcing the scientific rigor and credibility of the conducted studies.[4-6]. Thirdly, the authors confined their analysis solely to the occurrence or absence of liver-related mortality, while neglecting to account for the medical interventions undergone by the patients during the follow-up period[1]. It is imperative to elucidate the potential impact of these interventions on the study's findings. A comprehensive assessment of the medical interventions received by the patients is crucial for ensuring the accuracy and robustness of the study's conclusions. Ultimately, as highlighted by the authors, the primary limitation of this study is the relatively modest sample size[1]. Consequently, it is imperative that future research endeavors incorporate larger sample populations and adopt a multicenter design to validate the findings of the present study and further elucidate the pertinence to patients with AIH-PSC. Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported. REFERENCES 1 Jayabalan D, Huang Y, Calzadilla-Bertot L, Janjua M, de Boer B, Joseph J, Cheng W, Hazeldine S, Smith BW, MacQuillan GC, Wallace MC, Garas G, Adams LA, Jeffrey GP. Predictors of survival in autoimmune liver disease overlap syndromes. World J Hepatol 2024; 16: 1269-1277. [PMID:39351512 DOI: 10.4254/wjh.v16.i9.1269] 2 European Association for the Study of the Liver. EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. J Hepatol 2017; 67: 145-172. [PMID: 28427765 DOI: 10.1016/j.jhep.2017.03.022] 3 Czaja AJ. Diagnosis and Management of Autoimmune Hepatitis: Current Status and Future Directions. Gut Liver 2016; 10: 177-203. [PMID:26934884 DOI: 10.5009/gnl15352] 4 Lindor KD, Kowdley KV, Harrison ME. ACG Clinical Guideline: Primary Sclerosing Cholangitis. Am J Gastroenterol 2015; 110: 646-659, 660. [PMID: 25869391 DOI: 10.1038/ajg.2015.112] 5 Mack CL, Adams D, Assis DN, Kerkar N, Manns MP, Mayo MJ, Vierling JM, Alsawas M, Murad MH, Czaja AJ. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology 2020; 72: 671-722. [PMID: 31863477 DOI: 10.1002/hep.31065] 6 Lindor KD, Bowlus CL, Boyer J, Levy C, Mayo M. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology 2019; 69: 394-419. [PMID:30070375 DOI: 10.1002/hep.30145] " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Jayabalan D, Huang Y, Calzadilla-Bertot L, Janjua M, de Boer B, Joseph J, Cheng W, Hazeldine S, Smith BW, MacQuillan GC, Wallace MC, Garas G, Adams LA, Jeffrey GP. Predictors of survival in autoimmune liver disease overlap syndromes. <em>World J Hepatol</em> 2024; 16(9): 1269-1277 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 19 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i9/827.htm" class="author-comment" target="_blank"> "Comment on “Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool” Shuang Wu, Hong Cai* ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/1948-0210/full/v16/i9/827.htm" class="author-comment" target="_blank"> "Comment on “Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool” Shuang Wu, Hong Cai* Corresponding author: Hong Cai, Department of Dermatology, Air Force Medical Center, PLA, Beijing, 100142, P. R. China. ch1031@163.com Affiliation: Department of Dermatology, Department of Dermatology, Air Force Medical Center, PLA. No.30 of Fucheng Road. Beijing 100142, China. Key Words: Bibliometric analysis; Mesenchymal stem cells; Wound healing; To the Editor: We read the editorial by Vera et al [1]with great interest. In this editorial, the author conducted a keyword comparison and analysis of basic research published in BPG from 2023 to 2024, utilizing the bibliometric analysis approach of Shi et al[2]. This emphasizes the effectiveness of bibliometric analysis as a research tool. Additionally, the author examined several other articles on BPG, excluding WJSC, that were not included in Shi et al.'s bibliometric analysis. The findings indicate that although the application of bibliometric analysis in basic research remains limited, it can help identify key research directions and challenges in the field, advance the application of MSCs in the treatment of chronic wounds, and facilitate comprehensive analysis of related literature to better understand the current state of research and future development potential. First, the author conducted a keyword analysis of basic research on diabetic foot published in BPG, utilizing the bibliometric analysis by Shi et al. to highlight the value of bibliometric analysis in this field, which can provide clear directions for research hotspots. However, while Shi et al. used the Web of Science Core Collection database, the author of this article relied solely on the database affiliated with BPG for keyword comparisons. This discrepancy might introduce potential biases in the analysis results due to differences in research directions and acceptance criteria between journals[3,4]. Second, the author also pointed out limitations in Shi et al.'s bibliometric analysis: the analysis primarily focused on journals related to diabetic foot, while literature from other relevant fields was excluded from the search. This implies that some articles pertaining to stem cell therapy for diabetic foot may not have been incorporated, underscoring the necessity of expanding the search scope in future bibliometric analyses. Third, the author specifically analyzed literature on stem cell therapy for diabetic foot published in BPG during 2023-2024, while Shi et al.'s bibliometric analysis covered related literature from 2000 to 2023, thereby including a broader time span and a more extensive range of keywords. As basic research evolves, there may be past hotspot keywords that are now rarely used, or new research hotspots published in BPG that were not included in Shi et al.'s bibliometric analysis[5]. In summary, this is an editorial that employs bibliometric analysis to conduct a keyword analysis of relevant papers published in BPG from 2023 to 2024, elucidating the role of bibliometric analysis in basic research. If the analysis were to consider the acceptance criteria of different journals and the issue of timeliness more extensively, the conclusions could potentially be more compelling. References 1 Voinova VV, Vasina DV, Bonartsev AP. Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool. World J Stem Cells 2024; 16: 827–831. [PMID: 39351262 DOI: 10.4252/wjsc.v16.i9.827] 2 Shi H-S, Yuan X, Wu F-F, Li X-Y, Fan W-J, Yang X, Hu X-M, Liu G-B. Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives. World J Stem Cells 2024; 16: 33–53. [PMID: 38292441 DOI: 10.4252/wjsc.v16.i1.33] 3 Frank E. Authors’ Criteria for Selecting Journals. JAMA 1994; 272: 163–164. [DOI: 10.1001/jama.1994.03520020089026] 4 Garfield E. The History and Meaning of the Journal Impact Factor. JAMA 2006; 295: 90–93. [DOI: 10.1001/jama.295.1.90] 5 Tversky A, Kahneman D. Judgment under Uncertainty: Heuristics and Biases. Science 1974; 185: 1124–1131. [DOI: 10.1126/science.185.4157.1124] " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Voinova VV, Vasina DV, Bonartsev AP. Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool. <em>World J Stem Cells</em> 2024; 16(9): 827-831 </div> </div> </div> <div class="articleitem cl"> <div class="num fl"> 20 </div> <div class="item fl"> <div class="title authorreview-cropped inline"> <a href="https://www.wjgnet.com/2307-8960/full/v12/i33/6604.htm" class="author-comment" target="_blank"> "The article by Shen et al. offers important insights into the need for better screening practices for primary nasal tuberculosis (TB) ..." </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-cropped').toggleClass('inline').next('.authorreview-full').toggleClass('inline'); return false;">  [Read more] </a> </div> <div class="title authorreview-full"> <a href="https://www.wjgnet.com/2307-8960/full/v12/i33/6604.htm" class="author-comment" target="_blank"> "The article by Shen et al. offers important insights into the need for better screening practices for primary nasal tuberculosis (TB) in patients receiving tumor necrosis factor inhibitor (TNFi) therapy. The rarity of primary nasal TB, due to the nasal mucosa's natural defenses, along with the identified risk factors like diabetes, minimally invasive nasal surgery, and HIV, is well highlighted. We completely agree with the authors about the importance of early detection, especially in high-risk individuals. Their suggestion to increase screening frequency using the Interferon Gamma Release Assay (IGRA) makes sense. However, it’s also worth considering how practical this approach is in areas with lower TB prevalence. In regions with fewer resources, a more targeted strategy based on local TB rates and individual patient risk might be more appropriate. Another point to consider is how clinicians can best decide on the timing of these screenings. While IGRA testing is key, decisions on how often to test should also factor in a patient’s specific history, immune status, and any symptoms they might be experiencing. A one-size-fits-all approach may not work, so a more flexible screening schedule, tailored to both the patient’s needs and the region’s TB prevalence, could be even more effective. We look forward to further research in this area which will help shape future guidelines for managing TB risk in this patient group. " </a> <a href="javascript:void(0);" class="readmore" onclick="$(this).parents('.authorreview-full').toggleClass('inline').prev('.authorreview-cropped').toggleClass('inline'); return false;">  [Collapse] </a> </div> <div class="count"> Shen DX, Wang YW, Lin ZM, Jin D, Ying ZH, Li C. Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors. <em>World J Clin Cases</em> 2024; 12(33): 6604-6607 </div> </div> </div> <div class="more"> <span>872 items</span>  <a href="https://www.f6publishing.com/ReaderComments" target="_blank">Read more >></a> </div> </div> </div> </div> </div> <div class="down cl"> <div class="helpdesk cl"> <a href="https://www.f6publishing.com/HelpDesk" target="_blank">Write to the Help Desk</a> </div> <div class="subfooter cl"> <ul> <li> <b>ALL AUTHOR RESOURCES</b> </li> <li> <a href="https://www.wjgnet.com/bpg/GerInfo/312" target="_blank">Appeals and Complaints</a> </li> <li> <a 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