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class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Sadržaj</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">sakrij</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Početak</div> </a> </li> <li id="toc-Pregled" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pregled"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Pregled</span> </div> </a> <ul id="toc-Pregled-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Avonex" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Avonex"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Avonex</span> </div> </a> <ul id="toc-Avonex-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Rebif" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Rebif"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Rebif</span> </div> </a> <ul id="toc-Rebif-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-CinnoVex" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#CinnoVex"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>CinnoVex</span> </div> </a> <ul id="toc-CinnoVex-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Srodni_lekovi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Srodni_lekovi"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Srodni lekovi</span> </div> </a> <ul id="toc-Srodni_lekovi-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Povezano" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Povezano"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Povezano</span> </div> </a> <ul id="toc-Povezano-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Spoljašnje veze</span> </div> </a> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sadržaj" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Prikaži/sakrij sadržaj" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Prikaži/sakrij sadržaj</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading" lang="sh-Latn" dir="ltr"><span class="mw-page-title-main">Interferon beta-1a</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Prijedi na druge jezične varijante članka. Dostupno je na 15 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-15" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">15 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%AA%D8%B1%D9%81%D9%8A%D8%B1%D9%88%D9%86_%D8%A8%D9%8A%D8%AA%D8%A7_1-%D8%A3%D9%84%D9%81%D8%A7" title="إنترفيرون بيتا 1-ألفا — Arapski" lang="ar" hreflang="ar" data-title="إنترفيرون بيتا 1-ألفا" data-language-autonym="العربية" data-language-local-name="Arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%81%D8%B1%D9%88%D9%86_%D8%A8%D8%AA%D8%A7-%DB%B1%D8%A7%DB%8C" title="اینترفرون بتا-۱ای — South Azerbaijani" lang="azb" hreflang="azb" data-title="اینترفرون بتا-۱ای" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Interfer%C3%B3_beta_1a" title="Interferó beta 1a — Katalonski" lang="ca" hreflang="ca" data-title="Interferó beta 1a" data-language-autonym="Català" data-language-local-name="Katalonski" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Interferon_beta-1a" title="Interferon beta-1a — Češki" lang="cs" hreflang="cs" data-title="Interferon beta-1a" data-language-autonym="Čeština" data-language-local-name="Češki" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Interferon_beta-1a" title="Interferon beta-1a — Engleski" lang="en" hreflang="en" data-title="Interferon beta-1a" data-language-autonym="English" data-language-local-name="Engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%81%D8%B1%D9%88%D9%86_%D8%A8%D8%AA%D8%A7-%DB%B1%D8%A7%DB%8C" title="اینترفرون بتا-۱ای — Persijski" lang="fa" hreflang="fa" data-title="اینترفرون بتا-۱ای" data-language-autonym="فارسی" data-language-local-name="Persijski" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Interf%C3%A9ron_b%C3%AAta-1a" title="Interféron bêta-1a — Francuski" lang="fr" hreflang="fr" data-title="Interféron bêta-1a" data-language-autonym="Français" data-language-local-name="Francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%99%D7%A0%D7%98%D7%A8%D7%A4%D7%A8%D7%95%D7%9F_%D7%91%D7%98%D7%90_1a" title="אינטרפרון בטא 1a — Hebrejski" lang="he" hreflang="he" data-title="אינטרפרון בטא 1a" data-language-autonym="עברית" data-language-local-name="Hebrejski" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Interferone_beta-1a" title="Interferone beta-1a — Italijanski" lang="it" hreflang="it" data-title="Interferone beta-1a" data-language-autonym="Italiano" data-language-local-name="Italijanski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Interferonum_beta_1a" title="Interferonum beta 1a — Latinski" lang="la" hreflang="la" data-title="Interferonum beta 1a" data-language-autonym="Latina" data-language-local-name="Latinski" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Interferon_b%C3%A8ta-1a" title="Interferon bèta-1a — Holandski" lang="nl" hreflang="nl" data-title="Interferon bèta-1a" data-language-autonym="Nederlands" data-language-local-name="Holandski" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interfer%C3%A3o_beta-1a" title="Interferão beta-1a — Portugalski" lang="pt" hreflang="pt" data-title="Interferão beta-1a" data-language-autonym="Português" data-language-local-name="Portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D1%84%D0%B5%D1%80%D0%BE%D0%BD_%D0%B1%D0%B5%D1%82%D0%B0-1a" title="Интерферон бета-1a — Ruski" lang="ru" hreflang="ru" data-title="Интерферон бета-1a" data-language-autonym="Русский" data-language-local-name="Ruski" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Interferon_beta-1a" title="Interferon beta-1a — Srpski" lang="sr" hreflang="sr" data-title="Interferon beta-1a" data-language-autonym="Српски / srpski" data-language-local-name="Srpski" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Interferon_beta-1a" title="Interferon beta-1a — Vijetnamski" lang="vi" hreflang="vi" data-title="Interferon beta-1a" data-language-autonym="Tiếng Việt" data-language-local-name="Vijetnamski" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q2450337#sitelinks-wikipedia" title="Uredi međujezične poveznice" class="wbc-editpage">Uredi veze</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interferon_beta-1a" title="Vidi stranicu sadržaja [c]" accesskey="c"><span>Stranica</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Razgovor:Interferon_beta-1a" rel="discussion" title="Razgovarajte o sadržini ove stranice [t]" accesskey="t"><span>Razgovor</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown " lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Promijeni jezičnu varijantu" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Latinica</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-varlang-0" class="selected ca-variants-sh-Latn mw-list-item"><a href="/w/index.php?title=Interferon_beta-1a&variant=sh-latn" lang="sh-Latn" hreflang="sh-Latn"><span>Latinica</span></a></li><li id="ca-varlang-1" class="ca-variants-sh-Cyrl mw-list-item"><a href="/w/index.php?title=Interferon_beta-1a&variant=sh-cyrl" lang="sh-Cyrl" hreflang="sh-Cyrl"><span>Ћирилица</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Teme"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" lang="sh-Latn" dir="ltr"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Interferon_beta-1a"><span>Prikaži</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interferon_beta-1a&action=edit" title="Uredite izvorni kod ove stranice [e]" accesskey="e"><span>Uredi kod</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Interferon_beta-1a&action=history" title="Pogledajte prethodne verzije ove stranice [h]" accesskey="h"><span>Historija</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Pomagala"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" lang="sh-Latn" dir="ltr"> <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Alatke" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Alatke</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Alati</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">premjesti na bočnu traku</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">sakrij</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Više mogućnosti" lang="sh-Latn" dir="ltr"> <div class="vector-menu-heading"> Radnje </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Interferon_beta-1a"><span>Prikaži</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit" title="Uredite ovu stranicu [v]" accesskey="v"><span>Uredi</span></a></li><li id="ca-more-edit" 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src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/1AU1_Human_Interferon-Beta01.png/250px-1AU1_Human_Interferon-Beta01.png" decoding="async" width="250" height="174" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/1AU1_Human_Interferon-Beta01.png/375px-1AU1_Human_Interferon-Beta01.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/fb/1AU1_Human_Interferon-Beta01.png/500px-1AU1_Human_Interferon-Beta01.png 2x" data-file-width="2400" data-file-height="1673" /></a></span> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">(<a href="/wiki/IUPAC" class="mw-redirect" title="IUPAC">IUPAC</a>) ime </th></tr> <tr> <td colspan="2" style="text-align: center; vertical-align: top; background-color: #eee"><span style="font-size:11px">Human interferon beta</span> </td></tr> <tr> <th colspan="2" style="background-color: #ddd; text-align: center"><b>Klinički podaci</b> </th></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd"><b>Identifikatori</b> </th></tr> <tr> <td style="background-color: #def"><a href="/wiki/CAS_registarski_broj" title="CAS registarski broj">CAS broj</a> </td> <td style="background-color: #eee"><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?term=145258-61-3&rn=1">145258-61-3</a></span> </td></tr> <tr> <td style="background-color: #def; width: 90px"><a href="/wiki/Anatomsko_Terapeutsko_Hemijsko_Klasifikacioni_Sistem" class="mw-redirect" title="Anatomsko Terapeutsko Hemijsko Klasifikacioni Sistem">ATC kod</a> </td> <td style="background-color: #eee"><a href="/wiki/ATC_kod_L03" title="ATC kod L03">L03</a><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=L03AB07">AB07</a></span> </td></tr> <tr> <td style="background-color: #def"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a> </td> <td style="background-color: #eee"><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.drugbank.ca/cgi-bin/show_drug.cgi?CARD=BTD00093">BTD00093</a></span> </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd">Hemijski podaci </th></tr> <tr> <td style="background-color: #def"><a href="/wiki/Hemijska_formula" class="mw-redirect" title="Hemijska formula">Formula</a> </td> <td style="background-color: #eee"><a href="/wiki/Ugljenik" title="Ugljenik"><span style="color: rgb(000,000,000); font-weight: bold;">C</span></a><sub>908</sub><a href="/wiki/Vodonik" class="mw-redirect" title="Vodonik"><span style="color: rgb(77,77,77); font-weight: bold;">H</span></a><sub>1408</sub><a href="/wiki/Azot" class="mw-redirect" title="Azot"><span style="color: rgb(0,0,128); font-weight: bold;">N</span></a><sub>246</sub><a href="/wiki/Kiseonik" title="Kiseonik"><span style="color: rgb(116,35,35); font-weight: bold;">O</span></a><sub>252</sub><a href="/wiki/Sumpor" title="Sumpor"><span style="color: rgb(114,97,31); font-weight: bold;">S</span></a><sub>7</sub><sup> </sup> </td></tr> <tr> <td style="background-color: #def"><a href="/wiki/Molarna_masa" title="Molarna masa">Mol. masa</a> </td> <td style="background-color: #eee">20027.0 g/mol </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd"><a href="/wiki/(L)ADME(R)_sistem" class="mw-redirect" title="(L)ADME(R) sistem">Farmakokinetički</a> podaci </th></tr> <tr> <td style="vertical-align: top; background-color: #def"><a href="/wiki/Poluvreme_eliminacije" title="Poluvreme eliminacije">Poluvreme eliminacije</a> </td> <td style="background-color: #eee">10 časa </td></tr> <tr> <th colspan="2" style="text-align: center; background-color: #ddd"><b>Farmakoinformacioni podaci</b> </th></tr> <tr> <td style="vertical-align: top; background-color: #def"><a href="/wiki/Trudno%C4%87a" title="Trudnoća">Trudnoća</a> </td> <td style="background-color: #eee">? </td></tr> <tr> <td style="vertical-align: top; background-color: #def"><a href="/wiki/Regulacija_terapeutskih_dobara" title="Regulacija terapeutskih dobara">Pravni status</a> </td> <td style="background-color: #eee"> </td></tr> <tr> <td style="vertical-align: top; background-color: #def"><a href="/wiki/Na%C4%8Din_primene_leka" title="Način primene leka">Način primene</a> </td> <td style="background-color: #eee">Supkutano ili <a href="/w/index.php?title=IM&action=edit&redlink=1" class="new" title="IM (stranica ne postoji)">IM</a> </td></tr> </tbody></table> <p><b>Interferon beta-1a</b> je <a href="/wiki/Lek" class="mw-redirect" title="Lek">lek</a> u <a href="/wiki/Interferon" title="Interferon">interferon</a> familiji koja se koristi za tretiranje <a href="/wiki/Multipla_skleroza" title="Multipla skleroza">multiple skleroze</a> (MS).<sup id="cite_ref-pmid16207073_1-0" class="reference"><a href="#cite_note-pmid16207073-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Ovaj lek se proizvodi u ćelijama sisara, za razliku od <a href="/wiki/Interferon_beta-1b" title="Interferon beta-1b">Interferona beta-1b</a> koji se proizvodi u modifikovanim <a href="/wiki/E%C5%A1erihija_koli" class="mw-redirect" title="Ešerihija koli">E. coli</a> ćelijama. Za interferone je bilo pokazano da uzrokuju 18-38% umanjenje u stopi <a href="/wiki/Multipla_skleroza" title="Multipla skleroza">MS</a> relapsa, i da usporavaju progresiju invalidnosti kod MS pacijenata<sup id="cite_ref-About.com_2-0" class="reference"><a href="#cite_note-About.com-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>. Nijedan od proizvoda na tržištu ne može da iskoreni bolest, ali pacijenti koji pravovremeno počnu da koriste interferone magu da povoljno promenu prirodini tok bolesti. </p><p>Postoje dva glavna konkurenta na tržištu za ovaj lek, kao i jedan sličan proizvod: </p> <ul><li><b>Avonex</b> (<a href="/w/index.php?title=Biogen_Idec&action=edit&redlink=1" class="new" title="Biogen Idec (stranica ne postoji)">Biogen Idec</a>)</li> <li><b>Rebif</b> (<a href="/wiki/EMD_Serono" class="mw-redirect" title="EMD Serono">EMD Serono</a>)</li> <li><b>CinnoVex</b><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> (CinnaGen)</li></ul> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Pregled">Pregled</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=1" title="Uredi odjeljak Pregled" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=1" title="Uredi kôd odjeljka Pregled"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Veruje se da interferon beta bazirani lekovi ostvaruju njihove blagotvorne efekte na MS progresiju putem njihovih <a href="/wiki/Inflamacija" class="mw-disambig" title="Inflamacija">antiinflamatornih</a> osobina. Studije su utvrdile da interferon beta poboljšava integritet <a href="/wiki/Krvno-mo%C5%BEdana_barijera" title="Krvno-moždana barijera">krvno-moždane barijere</a> (BBB), koja je generalno oštećena kod <a href="/wiki/MS" class="mw-disambig" title="MS">MS</a> pacijenata, što omogućava povećanim količinama nepoželjnih supstanci da dođu u kontakt sa mozgom. Ovo <a href="/wiki/Krvno-mo%C5%BEdana_barijera" title="Krvno-moždana barijera">BBB</a> pojačavanje može biti dopunski faktor korisnim efektima interferona beta. Ove studije su sprovedene <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i>, tako da se ne zna u kojoj meri su ovi rezultati primenljivi kod ljudi. </p><p>Najčešće prijavljene nuspojave su poremećaji na mestu injekcije, simptomi <a href="/wiki/Grip#Simptomi" class="mw-redirect" title="Grip">slični gripu</a>, slabi rezultati na testu funkcije <a href="/wiki/Jetra" title="Jetra">jetre</a>, i abnormaliteti <a href="/wiki/Crvena_krvna_zrnca" class="mw-redirect" title="Crvena krvna zrnca">ćelija krvi</a>. U ozbiljnije nuspojave spadaju <a href="/wiki/Klini%C4%8Dka_depresija" title="Klinička depresija">depresija</a>, <a href="/wiki/Epilepsija" title="Epilepsija">epileptički napadi</a>, i problem <a href="/wiki/Jetra" title="Jetra">jetre</a>. </p><p>Dve glavne nuspojave su simptomi <a href="/wiki/Grip#Simptomi" class="mw-redirect" title="Grip">slični gripu</a> i reakcija na mestu injekcije. Simptomi poput gripa teže da se ispolje odmah nakon injekcije i traju negde oko pola dana.<sup id="cite_ref-SubcutaneousInjection_4-0" class="reference"><a href="#cite_note-SubcutaneousInjection-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Avonex_5-0" class="reference"><a href="#cite_note-Avonex-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Kod mnogih pacijenata, ovi simptomi su umanjeni s vremenom, dok neki pacijenti nastavljaju da se suočavaju sa ovim problemom u toku dužeg vremenskog perioda. Moguće je ublažiti ove simptome putem korišćenja doza koje sa manjom frekvencijom davanja i putem uzimanja lekova pre spavanja. Reakcije na mestu injekcije se mogu umanjiti rotiranjem strane ili upotrebom jedne od medikacija koje zahtevaju manje frekventne injekcije. Nuspojave su često dovoljno tegobni da mnogi pacijenti na kraju prekinu sa upotrebom interferona (ili <a href="/wiki/Glatiramer_acetat" title="Glatiramer acetat">glatiramer acetata</a>, uporedive bolest-modifikujuće terapije koja zahteva regularne injekcije). </p><p>Dok ovi lekovi poboljšavaju određene rezultate dijagnostičkih testova oni ne iskorenjuju <a href="/wiki/MS" class="mw-disambig" title="MS">MS</a>, i mnogi pacijenti smatraju da nema primetnog poboljšanja i ozbiljne nuspojave koji značajno umanjuju kvalitet života. Tokom vremena, <a href="/wiki/Fiziolo%C5%A1ka_tolerancija" class="mw-redirect" title="Fiziološka tolerancija">fiziološka tolerancija</a> i umanjena efektivnost se mogu javiti usled razvoja <a href="/wiki/Antitelo" title="Antitelo">antitela</a> za lekove. Nuspojave mogu trajati čak i nakon prestanka tretmana. Mesečna doza lekova Avonex ili Rebif može koštati od $1,600 do više od $3,000 <a href="/wiki/USD" class="mw-redirect" title="USD">USD</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Avonex">Avonex</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=2" title="Uredi odjeljak Avonex" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=2" title="Uredi kôd odjeljka Avonex"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Avonex je odobren u <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a> <a href="/wiki/1996" title="1996">1996</a> godine, i u <a href="/wiki/Evropa" title="Evropa">Evropi</a> u <a href="/wiki/1997" title="1997">1997</a>. On je registrovan u više od 80 zemalja širom sveta. On je vodeća <a href="/wiki/MS" class="mw-disambig" title="MS">MS</a> terapija u <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a>, sa oko 40% ukupnog tržišta, i u <a href="/wiki/Evropa" title="Evropa">Evropi</a>, sa oko 30% tržišta. Njega proizvodi <a href="/w/index.php?title=Biogen_Idec&action=edit&redlink=1" class="new" title="Biogen Idec (stranica ne postoji)">Biogen Idec</a> <a href="/w/index.php?title=Biotehnogija&action=edit&redlink=1" class="new" title="Biotehnogija (stranica ne postoji)">biotehnološka</a> kompanija, originalno pod zaštitom od konkurencije u <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a> pod <a href="/w/index.php?title=Zakon_za_lekove_retkih_bolesti&action=edit&redlink=1" class="new" title="Zakon za lekove retkih bolesti (stranica ne postoji)">zakonom za lekove retkih bolesti</a> (<a href="/wiki/Engleski_jezik" title="Engleski jezik">engl.</a> <i><span lang="en">Orphan Drug Act</span></i>). </p><p>Avonex se prodaje u dve formulacije, liofilizovani prah koji zahteva rekonstituciju, i unapred pomešana tečnost za injekcije. On se administrira jednom nedeljno putem intramuskularne injekcije. </p> <div class="mw-heading mw-heading2"><h2 id="Rebif">Rebif</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=3" title="Uredi odjeljak Rebif" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=3" title="Uredi kôd odjeljka Rebif"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Rebif je bolest-modifikujući lek (DMD) koje se koristi u tretmanu multiple skleroze u slučajevima klinički izolovanih sindroma kao i kod <a href="/wiki/Multipla_skleroza#Tipovi_bolesti" title="Multipla skleroza">relapsnih formi multiple skleroze</a>. On je sličan interferon beta <a href="/wiki/Protein" title="Protein">proteinu</a> proizvedenom u ljudskom telu. Njega zajedno prodaju <a href="/wiki/Merk_KGaA" title="Merk KGaA">EMD Serono</a> i <a href="/wiki/Pfizer" title="Pfizer">Pfizer</a> u <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a> pod zaštitom <a href="/w/index.php?title=Zakon_za_lekove_retkih_bolesti&action=edit&redlink=1" class="new" title="Zakon za lekove retkih bolesti (stranica ne postoji)">zakona za lekove retkih bolesti</a>. On je odobren u <a href="/wiki/Evropa" title="Evropa">Evropi</a> <a href="/wiki/1998" title="1998">1998</a> godine i u <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a> <a href="/wiki/2002" title="2002">2002</a>. Ovaj lek je registrovan u više od 80 zemalja širom sveta. Rebif se administrira putem supkutane injekcije tri puta nedeljno. On se može čuvati na sobnoj temperaturi do 30 dana. </p> <div class="mw-heading mw-heading2"><h2 id="CinnoVex">CinnoVex</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=4" title="Uredi odjeljak CinnoVex" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=4" title="Uredi kôd odjeljka CinnoVex"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/w/index.php?title=CinnoVex&action=edit&redlink=1" class="new" title="CinnoVex (stranica ne postoji)">CinnoVex</a> je trgovačko ime za rekombinantni interferon beta 1-a, koji se proizvodi kao biogenerični lek u <a href="/wiki/Iran" title="Iran">Iranu</a>. On se proizvodi u liofilizovanom obliku i prodaje u obliku injekcija. </p> <div class="mw-heading mw-heading2"><h2 id="Srodni_lekovi">Srodni lekovi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=5" title="Uredi odjeljak Srodni lekovi" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=5" title="Uredi kôd odjeljka Srodni lekovi"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Blisko srodni lek je <a href="/wiki/Interferon_beta-1b" title="Interferon beta-1b">Interferon beta-1b</a>, koji se takođe koristi u tretmanu <a href="/wiki/Multipla_skleroza" title="Multipla skleroza">multiple skleroze</a>. On ima veoma sličan profil. Interferon beta-1b prodaje <a href="/w/index.php?title=Berlex&action=edit&redlink=1" class="new" title="Berlex (stranica ne postoji)">Berlex</a> i <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a> kao <a href="/w/index.php?title=Betaseron&action=edit&redlink=1" class="new" title="Betaseron (stranica ne postoji)">Betaseron</a> i van <a href="/wiki/SAD" class="mw-redirect" title="SAD">SAD</a> kao <a href="/w/index.php?title=Betaferon&action=edit&redlink=1" class="new" title="Betaferon (stranica ne postoji)">Betaferon</a> (<a href="/w/index.php?title=Schering&action=edit&redlink=1" class="new" title="Schering (stranica ne postoji)">Schering AG</a>). </p><p><a href="/w/index.php?title=Extavia&action=edit&redlink=1" class="new" title="Extavia (stranica ne postoji)">Extavia</a> novi brend interferona beta-1b na tržištu. <a href="/wiki/Novartis" title="Novartis">Novartis</a> je uveo u produju ovaj lek <a href="/wiki/2009" title="2009">2009</a> godine. </p> <div class="mw-heading mw-heading2"><h2 id="Povezano">Povezano</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=6" title="Uredi odjeljak Povezano" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=6" title="Uredi kôd odjeljka Povezano"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Interferon_beta-1b" title="Interferon beta-1b">Interferon beta-1b</a></li> <li><a href="/wiki/Multipla_skleroza" title="Multipla skleroza">Multipla skleroza</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=7" title="Uredi odjeljak Literatura" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=7" title="Uredi kôd odjeljka Literatura"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r41556849">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-pmid16207073-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid16207073_1-0">↑</a></span> <span class="reference-text"> <span class="citation Journal">Murdoch D, Lyseng-Williamson KA (2005). „Spotlight on subcutaneous recombinant interferon-beta-1a (Rebif) in relapsing-remitting multiple sclerosis”. <i>BioDrugs</i> <b>19</b> (5): 323–5. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">DOI</a>:<a rel="nofollow" class="external text" href="https://dx.doi.org/10.2165%2F00063030-200519050-00005">10.2165/00063030-200519050-00005</a>. <a href="/wiki/PubMed_Identifier" class="mw-redirect" title="PubMed Identifier">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/16207073">16207073</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Spotlight+on+subcutaneous+recombinant+interferon-beta-1a+%28Rebif%29+in+relapsing-remitting+multiple+sclerosis&rft.jtitle=BioDrugs&rft.aulast=Murdoch+D%2C+Lyseng-Williamson+KA&rft.au=Murdoch+D%2C+Lyseng-Williamson+KA&rft.date=2005&rft.volume=19&rft.issue=5&rft.pages=323%E2%80%935&rft_id=info:doi/10.2165%2F00063030-200519050-00005&rft_id=info:pmid/16207073&rfr_id=info:sid/en.wikipedia.org:Interferon_beta-1a"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-About.com-2"><span class="mw-cite-backlink"><a href="#cite_ref-About.com_2-0">↑</a></span> <span class="reference-text"> <span class="citation web">Stachowiak PhD., Julie (2008). <a rel="nofollow" class="external text" href="http://ms.about.com/od/treatments/a/AVONEX.htm">„Is Avonex Right for You?”</a><span class="reference-accessdate">. Pristupljeno 7. 5. 2008</span>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Is+Avonex+Right+for+You%3F&rft.atitle=&rft.aulast=Stachowiak+PhD.&rft.aufirst=Julie&rft.au=Stachowiak+PhD.%2C%26%2332%3BJulie&rft.date=2008&rft_id=http%3A%2F%2Fms.about.com%2Fod%2Ftreatments%2Fa%2FAVONEX.htm&rfr_id=info:sid/en.wikipedia.org:Interferon_beta-1a"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="citation web"><a rel="nofollow" class="external text" href="http://www.cinnagen.com">„CinnaGen”</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=CinnaGen&rft.atitle=&rft_id=http%3A%2F%2Fwww.cinnagen.com&rfr_id=info:sid/en.wikipedia.org:Interferon_beta-1a"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-SubcutaneousInjection-4"><span class="mw-cite-backlink"><a href="#cite_ref-SubcutaneousInjection_4-0">↑</a></span> <span class="reference-text"><span class="citation web"><a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/medlineplus/druginfo/meds/a604005.html">„Interferon beta-1a Subcutaneous Injection”</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Interferon+beta-1a+Subcutaneous+Injection&rft.atitle=&rft_id=http%3A%2F%2Fwww.nlm.nih.gov%2Fmedlineplus%2Fdruginfo%2Fmeds%2Fa604005.html&rfr_id=info:sid/en.wikipedia.org:Interferon_beta-1a"><span style="display: none;"> </span></span></span> </li> <li id="cite_note-Avonex-5"><span class="mw-cite-backlink"><a href="#cite_ref-Avonex_5-0">↑</a></span> <span class="reference-text"><span class="citation web"><a rel="nofollow" class="external text" href="http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/TherapeuticBiologicApplications/ucm087012.pdf">„Avonex (Interferon beta-la)”</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.btitle=Avonex+%28Interferon+beta-la%29&rft.atitle=&rft_id=http%3A%2F%2Fwww.fda.gov%2Fdownloads%2FDrugs%2FDevelopmentApprovalProcess%2FHowDrugsareDevelopedandApproved%2FApprovalApplications%2FTherapeuticBiologicApplications%2Fucm087012.pdf&rfr_id=info:sid/en.wikipedia.org:Interferon_beta-1a"><span style="display: none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interferon_beta-1a&veaction=edit&section=8" title="Uredi odjeljak Spoljašnje veze" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interferon_beta-1a&action=edit&section=8" title="Uredi kôd odjeljka Spoljašnje veze"><span>uredi kod</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="noprint tright portal" style="border:solid #aaa 1px;margin:0.5em 0 0.5em 0.5em;"> <table style="background:#f9f9f9; font-size:85%; line-height:110%; max-width:250px;"> <tbody><tr> <td style="text-align: center;"><span typeof="mw:File"><a href="/wiki/Datoteka:Portal.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/32px-Portal.svg.png" decoding="async" width="32" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/47px-Portal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c9/Portal.svg/63px-Portal.svg.png 2x" data-file-width="36" data-file-height="32" /></a></span> </td> <td style="padding: 0 0.2em; vertical-align: middle"><i><b><a href="/w/index.php?title=Portal:Medicina&action=edit&redlink=1" class="new" title="Portal:Medicina (stranica ne postoji)">Portal Medicina </a></b></i> </td></tr> <tr valign="middle"> <td style="text-align: center;"><span typeof="mw:File"><a href="/wiki/Datoteka:P_chemistry.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/P_chemistry.svg/31px-P_chemistry.svg.png" decoding="async" width="31" height="28" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/P_chemistry.svg/47px-P_chemistry.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/ca/P_chemistry.svg/62px-P_chemistry.svg.png 2x" data-file-width="400" data-file-height="360" /></a></span> </td> <td style="padding: 0 0.2em; vertical-align: middle"><i><b><a href="/w/index.php?title=Portal:Hemija&action=edit&redlink=1" class="new" title="Portal:Hemija (stranica ne postoji)">Portal Hemija </a></b></i> </td></tr> </tbody></table></div> <ul><li><a href="/wiki/Medical_Subject_Headings" class="mw-redirect" title="Medical Subject Headings">MeSH</a> <i><a rel="nofollow" class="external text" href="//www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Avonex">Avonex</a></i></li></ul> <ul><li><span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/Cytokines" title="Cytokines"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/12px-Commons-logo.svg.png" decoding="async" width="12" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/18px-Commons-logo.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/Commons-logo.svg/24px-Commons-logo.svg.png 2x" data-file-width="1024" data-file-height="1376" /></a></span> <a href="https://commons.wikimedia.org/wiki/Glavna_strana" class="extiw" title="commons:Glavna strana">Vikimedija ostava</a> ima još multimedijalnih fajlova vezanih za: <b><i><a href="https://commons.wikimedia.org/wiki/Category:Cytokines" class="extiw" title="commons:Category:Cytokines">Interferon beta-1a</a></i></b></li></ul> <div style="clear:both;"></div> <div class="navbox-styles nomobile"><style data-mw-deduplicate="TemplateStyles:r41348688">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output 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href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat"><abbr title="Pogledajte šablon" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">p</abbr></a></li><li class="nv-razgovor"><a href="/wiki/Razgovor_o_%C5%A1ablonu:Citokini-lat" title="Razgovor o šablonu:Citokini-lat"><abbr title="Razgovarajte o šablonu" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">r</abbr></a></li><li class="nv-uredi"><a class="external text" href="https://sh.wikipedia.org/w/index.php?title=%C5%A0ablon:Citokini-lat&action=edit"><abbr title="Uredite šablon" style=";background:#e7dcc3;background:none transparent;color:inherit;border:none;box-shadow:none;padding:0;">u</abbr></a></li></ul></div><div id="Ćelijska_komunikacija:_Citokini" style="font-size:114%;margin:0 4em"><a href="/wiki/%C4%86elijska_komunikacija" title="Ćelijska komunikacija">Ćelijska komunikacija</a>: <a href="/wiki/Citokini" class="mw-redirect" title="Citokini">Citokini</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po familiji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-1" class="mw-disambig" title="IL-1">IL-1</a> superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_1" title="Interleukin 1">1</a> (<a href="/wiki/Antagonist_interleukin-1_receptora" title="Antagonist interleukin-1 receptora">1Ra</a>) •  <a href="/wiki/Interleukin_18" title="Interleukin 18">18</a> •  <a href="/wiki/Interleukin_33" title="Interleukin 33">33</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">poput <a href="/wiki/IL-6" class="mw-disambig" title="IL-6">IL-6</a>/<a href="/wiki/Glikoprotein_130" title="Glikoprotein 130">gp130</a> koristeći</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_6" title="Interleukin 6">6</a>  •  <a href="/wiki/Interleukin_11" title="Interleukin 11">11</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_30" title="Interleukin 30">30</a> •  <a href="/wiki/Interleukin_31" title="Interleukin 31">31</a> (+ne IL <a href="/wiki/Onkostatin_M" title="Onkostatin M">Onkostatin M</a>, <a href="/wiki/Inhibitorni_faktor_leukemije" title="Inhibitorni faktor leukemije">Inhibitorni faktor leukemije</a>, <a href="/wiki/Cilijarni_neurotrofni_faktor" title="Cilijarni neurotrofni faktor">Cilijarni neurotrofni faktor</a>, <a href="/wiki/Kardiotrofin_1" title="Kardiotrofin 1">Kardiotrofin 1</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-10" class="mw-disambig" title="IL-10">IL-10</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_10" title="Interleukin 10">10</a> •  <a href="/wiki/Interleukin_19" title="Interleukin 19">19</a> •  <a href="/wiki/Interleukin_20" title="Interleukin 20">20</a> •  <a href="/wiki/Interleukin_22" title="Interleukin 22">22</a> •  <a href="/wiki/Interleukin_24" title="Interleukin 24">24</a> •  <a href="/wiki/Interleukin_26" title="Interleukin 26">26</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">Interferon tip III</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_28" title="Interleukin 28">28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">29</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Zajedni%C4%8Dki_gama_lanac" class="mw-redirect" title="Zajednički gama lanac">Zajednički γ-lanac</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_2" title="Interleukin 2">2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">15</a> •  <a href="/wiki/Interleukin_3" title="Interleukin 3">3</a> •  <a href="/wiki/Interleukin_4" title="Interleukin 4">4</a> •  <a href="/wiki/Interleukin_7" title="Interleukin 7">7</a> •  <a href="/wiki/Interleukin_9" title="Interleukin 9">9</a> •  <a href="/wiki/Interleukin_13" title="Interleukin 13">13</a> •  <a href="/wiki/Interleukin_21" title="Interleukin 21">21</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/IL-12" class="mw-disambig" title="IL-12">IL-12</a> familija</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_12" title="Interleukin 12">12</a> (<a href="/wiki/Interleukin_12B" title="Interleukin 12B">B</a>) •  <a href="/wiki/Interleukin_23" title="Interleukin 23">23</a> •  <a href="/wiki/Interleukin_27" title="Interleukin 27">27</a> •  <a href="/wiki/Interleukin_35" title="Interleukin 35">35</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Drugi</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_5" title="Interleukin 5">5</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/Interleukin_14" title="Interleukin 14">14</a> •  <a href="/wiki/Interleukin_16" title="Interleukin 16">16</a> •  <a href="/wiki/Interleukin_17" title="Interleukin 17">17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">25</a> (<a href="/wiki/Interleukin_17A" title="Interleukin 17A">A</a>) •  <a href="/wiki/Interleukin_32" title="Interleukin 32">32</a>  •  <a href="/wiki/Interleukin_34" title="Interleukin 34">34</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Hemokini" class="mw-redirect" title="Hemokini">Hemokini</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CCL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CCL1" title="CCL1">1</a> •  <a href="/wiki/CCL2" title="CCL2">2</a> •  <a href="/wiki/Makrofagni_inflamatorni_protein" title="Makrofagni inflamatorni protein">3</a> •  <a href="/wiki/CCL4" title="CCL4">4</a> •  <a href="/wiki/CCL5" title="CCL5">5</a> •  <a href="/wiki/CCL6" title="CCL6">6</a> •  <a href="/wiki/CCL7" title="CCL7">7</a> •  <a href="/wiki/CCL8" title="CCL8">8</a> •  <a href="/wiki/CCL9" title="CCL9">9</a> •  <a href="/wiki/CCL9" title="CCL9">10</a> •  <a href="/wiki/CCL11" title="CCL11">11</a> •  <a href="/wiki/CCL12" title="CCL12">12</a> •  <a href="/wiki/CCL13" title="CCL13">13</a> •  <a href="/wiki/CCL14" title="CCL14">14</a> •  <a href="/wiki/CCL15" title="CCL15">15</a> •  <a href="/wiki/CCL16" title="CCL16">16</a> •  <a href="/wiki/CCL17" title="CCL17">17</a> •  <a href="/wiki/CCL18" title="CCL18">18</a> •  <a href="/wiki/CCL19" title="CCL19">19</a> •  <a href="/wiki/CCL20" title="CCL20">20</a> •  <a href="/wiki/CCL21" title="CCL21">21</a> •  <a href="/wiki/CCL22" title="CCL22">22</a> •  <a href="/wiki/CCL23" title="CCL23">23</a> •  <a href="/wiki/CCL24" title="CCL24">24</a> •  <a href="/wiki/CCL25" title="CCL25">25</a> •  <a href="/wiki/CCL26" title="CCL26">26</a> •  <a href="/wiki/CCL27" title="CCL27">27</a> •  <a href="/wiki/CCL28" title="CCL28">28</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CXCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CXCL1" title="CXCL1">1</a> •  <a href="/wiki/CXCL2" title="CXCL2">2</a> •  <a href="/wiki/CXCL3" title="CXCL3">3</a> •  <a href="/wiki/Trombocit_faktor_4" title="Trombocit faktor 4">4</a> •  <a href="/wiki/CXCL5" title="CXCL5">5</a> •  <a href="/wiki/CXCL6" title="CXCL6">6</a> •  <a href="/wiki/CXCL7" title="CXCL7">7</a> •  <a href="/wiki/Interleukin_8" title="Interleukin 8">8</a> •  <a href="/wiki/CXCL9" title="CXCL9">9</a> •  <a href="/wiki/CXCL10" title="CXCL10">10</a> •  <a href="/wiki/CXCL11" title="CXCL11">11</a> •  <a href="/wiki/CXCL12" title="CXCL12">12</a> •  <a href="/wiki/CXCL13" title="CXCL13">13</a> •  <a href="/wiki/CXCL14" title="CXCL14">14</a> •  <a href="/wiki/CXCL15" title="CXCL15">15</a> •  <a href="/wiki/CXCL16" title="CXCL16">16</a> •  <a href="/wiki/CXCL17" title="CXCL17">17</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">CX3CL</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CX3CL1" title="CX3CL1">1</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">XCL</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/XCL1" title="XCL1">1</a> •  <a href="/wiki/XCL2" title="XCL2">2</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Faktori_nekroze_tumora" title="Faktori nekroze tumora">TNF</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">Glavni</div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;">TNF (<a href="/wiki/Ligand_(biohemija)" title="Ligand (biohemija)">ligand</a>) superfamilija</div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/4-1BB_ligand" title="4-1BB ligand">4-1BB ligand</a> •  <a href="/wiki/Faktor_aktivacije_B-%C4%87elija" title="Faktor aktivacije B-ćelija">Faktor aktivacije B-ćelija</a> •  <a href="/wiki/Fas_ligand" title="Fas ligand">FAS ligand</a> •  <a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a> •  <a href="/wiki/OX40L" title="OX40L">OX40L</a> •  <a href="/wiki/RANKL" title="RANKL">RANKL</a> •  <a href="/wiki/TRAIL" title="TRAIL">TRAIL</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Klaster_diferencijacije" title="Klaster diferencijacije">Klaster diferencijacije</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/CD70" title="CD70">CD70</a> •  <a href="/wiki/CD153" title="CD153">CD153</a> •  <a href="/wiki/CD154" title="CD154">CD154</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon" title="Interferon">Interferon</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_I" title="Interferon tip I">I</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">alfa ( <a href="/wiki/Pegilirani_interferon_alfa-2a" title="Pegilirani interferon alfa-2a">Pegilirani 2a</a>, <a href="/wiki/Pegilirani_interferon_alfa-2b" title="Pegilirani interferon alfa-2b">Pegilirani 2b</a>), beta (<a class="mw-selflink selflink">1a</a>, <a href="/wiki/Interferon_beta-1b" title="Interferon beta-1b">1b</a>)</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_II" title="Interferon tip II">II</a></div></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interferon-gama" title="Interferon-gama">Gama</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;padding-left:0em;padding-right:0em;background-color: AntiqueWhite"><div style="padding:0em 0.75em;"><a href="/wiki/Interferon_tip_III" title="Interferon tip III">III</a></div></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Interleukin_28" title="Interleukin 28">IL-28</a> •  <a href="/wiki/Interleukin_29" title="Interleukin 29">IL-29</a></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Drugi</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Monokin" title="Monokin">Monokin</a> •  <a href="/wiki/Limfokin" title="Limfokin">Limfokin</a> (<a href="/wiki/Limfotoksin" title="Limfotoksin">Limfotoksin</a>, <a href="/wiki/Faktor_transfera" title="Faktor transfera">Faktor transfera</a>) •  <a href="/wiki/Faktor_rasta" title="Faktor rasta">Faktor rasta</a> •  <a href="/wiki/Hematopoeza" title="Hematopoeza">Hematopoeza</a> (<a href="/wiki/Faktor_stem_%C4%87elija" title="Faktor stem ćelija">Faktor stem ćelija</a>, <a href="/wiki/Faktor_stimulacije_kolonije" title="Faktor stimulacije kolonije">Faktor stimulacije kolonije</a>) •  <a href="/wiki/GPI_(gen)" title="GPI (gen)">Faktor autokrinog motiliteta</a> •  <a href="/wiki/Osteopontin" title="Osteopontin">Osteopontin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Po funkciji</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><i><a href="/wiki/Proinflamatorni_citokin" title="Proinflamatorni citokin">proinflamatorni citokin</a></i> (<a href="/wiki/Interleukin_1" title="Interleukin 1">IL-1</a>, <a href="/wiki/Faktor_nekroze_tumora-alfa" title="Faktor nekroze tumora-alfa">TNF-alfa</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>1</i></a> (<a href="/wiki/Interferon-gama" title="Interferon-gama">INF-gama</a> i <a href="/wiki/Faktor_nekroze_tumora-beta" class="mw-redirect" title="Faktor nekroze tumora-beta">TNF-beta</a>) •  <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije"><i>T<sub>h</sub>2</i></a> (<a href="/wiki/Interleukin_4" title="Interleukin 4">IL-4</a>, <a href="/wiki/Interleukin_5" title="Interleukin 5">IL-5</a>, <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a>, <a href="/wiki/Interleukin_10" title="Interleukin 10">IL-10</a>, <a href="/wiki/Interleukin_13" title="Interleukin 13">IL-13</a>) •  <a href="/wiki/T_pomo%C4%87ne_17_%C4%87elije" title="T pomoćne 17 ćelije"><i>T<sub>h</sub>17</i></a> (<a href="/wiki/Interleukin_17" title="Interleukin 17">IL-17</a>,<a href="/wiki/Interleukin_22" title="Interleukin 22">IL-22</a>)</div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i><a href="/wiki/%C5%A0ablon:Biohemija_metanavs-lat" title="Šablon:Biohemija metanavs-lat">B</a> <a href="/wiki/%C5%A0ablon:Prenos_signala-lat" title="Šablon:Prenos signala-lat">trdu</a>: <a href="/w/index.php?title=%C5%A0ablon:Intercelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intercelularni signalni peptidi i proteini-lat (stranica ne postoji)">peptidi</a> (<a href="/wiki/%C5%A0ablon:Neuropeptidi-lat" title="Šablon:Neuropeptidi-lat">nrpl</a>/<a href="/wiki/%C5%A0ablon:Faktori_rasta-lat" title="Šablon:Faktori rasta-lat">grfl</a>/<a href="/wiki/%C5%A0ablon:Citokini-lat" title="Šablon:Citokini-lat">cytl</a>/<a href="/wiki/%C5%A0ablon:Hormoni-lat" title="Šablon:Hormoni-lat">horl</a>), <a href="/w/index.php?title=%C5%A0ablon:Receptori_%C4%87elijske_povr%C5%A1ine-lat&action=edit&redlink=1" class="new" title="Šablon:Receptori ćelijske površine-lat (stranica ne postoji)">receptori</a> (<a href="/w/index.php?title=%C5%A0ablon:Ligand-kontrolisani_jonski_kanali-lat&action=edit&redlink=1" class="new" title="Šablon:Ligand-kontrolisani jonski kanali-lat (stranica ne postoji)">lgic</a>, <a href="/w/index.php?title=%C5%A0ablon:Enzim-vezani_receptori-lat&action=edit&redlink=1" class="new" title="Šablon:Enzim-vezani receptori-lat (stranica ne postoji)">enzr</a>, <a href="/wiki/%C5%A0ablon:G_protein_spregnuti_receptori-lat" title="Šablon:G protein spregnuti receptori-lat">gprc</a>, <a href="/wiki/%C5%A0ablon:Imunoglobulinska_superfamilija_imunskih_receptora-lat" title="Šablon:Imunoglobulinska superfamilija imunskih receptora-lat">igsr</a>, <a href="/w/index.php?title=%C5%A0ablon:Integrini-lat&action=edit&redlink=1" class="new" title="Šablon:Integrini-lat (stranica ne postoji)">intg</a>, <a href="/wiki/%C5%A0ablon:Neuropeptidni_receptori-lat" title="Šablon:Neuropeptidni receptori-lat">nrpr</a>/<a href="/wiki/%C5%A0ablon:Receptori_faktora_rasta-lat" title="Šablon:Receptori faktora rasta-lat">grfr</a>/<a href="/wiki/%C5%A0ablon:Citokinski_receptori-lat" class="mw-redirect" title="Šablon:Citokinski receptori-lat">cytr</a>), <a href="/w/index.php?title=%C5%A0ablon:Intracelularni_signalni_peptidi_i_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Intracelularni signalni peptidi i proteini-lat (stranica ne postoji)">itra</a> (<a href="/w/index.php?title=%C5%A0ablon:Adapterski_proteini-lat&action=edit&redlink=1" class="new" title="Šablon:Adapterski proteini-lat (stranica ne postoji)">adap</a>, <a href="/wiki/%C5%A0ablon:Regulatori_GTP-vezuju%C4%87ih_proteina-lat" title="Šablon:Regulatori GTP-vezujućih proteina-lat">gbpr</a>, <a href="/w/index.php?title=%C5%A0ablon:Aktivacija_MAP_kinaze-lat&action=edit&redlink=1" class="new" title="Šablon:Aktivacija MAP kinaze-lat (stranica ne postoji)">mapk</a>), <a href="/w/index.php?title=%C5%A0ablon:Kalcjiumska_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:Kalcjiumska signalizacija-lat (stranica ne postoji)">calc</a>, <a href="/wiki/%C5%A0ablon:Lipidna_signalizacija-lat" title="Šablon:Lipidna signalizacija-lat">lipd</a>, signalni putevi (<a href="/w/index.php?title=%C5%A0ablon:Hedgehog_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hedgehog signalni put-lat (stranica ne postoji)">hedp</a>, <a href="/w/index.php?title=%C5%A0ablon:Wnt_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Wnt signalni put-lat (stranica ne postoji)">wntp</a>, <a href="/w/index.php?title=%C5%A0ablon:TGF_beta_signalizacija-lat&action=edit&redlink=1" class="new" title="Šablon:TGF beta signalizacija-lat (stranica ne postoji)">tgfp</a>+<a href="/wiki/%C5%A0ablon:MAPK_ERK_signalni_put-lat" title="Šablon:MAPK ERK signalni put-lat">mapp</a>, <a href="/w/index.php?title=%C5%A0ablon:Notch_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Notch signalni put-lat (stranica ne postoji)">notp</a>, <a href="/w/index.php?title=%C5%A0ablon:JAK-STAT_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:JAK-STAT signalni put-lat (stranica ne postoji)">jakp</a>, <a href="/wiki/%C5%A0ablon:Apoptozni_signalni_put-lat" title="Šablon:Apoptozni signalni put-lat">fsap</a>, <a href="/w/index.php?title=%C5%A0ablon:Hippo_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:Hippo signalni put-lat (stranica ne postoji)">hipp</a>, <a href="/w/index.php?title=%C5%A0ablon:TLR_signalni_put-lat&action=edit&redlink=1" class="new" title="Šablon:TLR signalni put-lat (stranica ne postoji)">tlrp</a>)</i></div></td></tr></tbody></table></div> <p><a href="/w/index.php?title=%C5%A0ablon:Imunostimulanti&action=edit&redlink=1" class="new" title="Šablon:Imunostimulanti (stranica ne postoji)">Šablon:Imunostimulanti</a> </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="" lang="sh-Latn" dir="ltr">Izvor: <a dir="ltr" href="https://sh.wikipedia.org/w/index.php?title=Interferon_beta-1a&oldid=42171000">https://sh.wikipedia.org/w/index.php?title=Interferon_beta-1a&oldid=42171000</a></div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Posebno:Kategorije" title="Posebno:Kategorije">Kategorije</a>: <ul><li><a href="/wiki/Kategorija:Interleukini" 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