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Cho</title> <meta name="description" content="Search results for: Satoshi Cho"> <meta name="keywords" content="Satoshi Cho"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Satoshi Cho" name="q" aria-label="Search"> <button class="btn btn-light my-2 my-sm-0" type="submit"><i class="fas fa-search"></i></button> </form> </div> <div class="collapse navbar-collapse mt-1" id="navbarMenu"> <ul class="navbar-nav ml-auto align-items-center" id="mainNavMenu"> <li class="nav-item"> <a class="nav-link" href="https://waset.org/conferences" title="Conferences in 2024/2025/2026">Conferences</a> </li> <li class="nav-item"> <a class="nav-link" href="https://waset.org/disciplines" title="Disciplines">Disciplines</a> </li> <li 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Satoshi Cho"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 23</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Satoshi Cho</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">23</span> Cell-Cell Interactions in Diseased Conditions Revealed by Three Dimensional and Intravital Two Photon Microscope: From Visualization to Quantification</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Nishimura">Satoshi Nishimura</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Although much information has been garnered from the genomes of humans and mice, it remains difficult to extend that information to explain physiological and pathological phenomena. This is because the processes underlying life are by nature stochastic and fluctuate with time. Thus, we developed novel "in vivo molecular imaging" method based on single and two-photon microscopy. We visualized and analyzed many life phenomena, including common adult diseases. We integrated the knowledge obtained, and established new models that will serve as the basis for new minimally invasive therapeutic approaches. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=two%20photon%20microscope" title="two photon microscope">two photon microscope</a>, <a href="https://publications.waset.org/abstracts/search?q=intravital%20visualization" title=" intravital visualization"> intravital visualization</a>, <a href="https://publications.waset.org/abstracts/search?q=thrombus" title=" thrombus"> thrombus</a>, <a href="https://publications.waset.org/abstracts/search?q=artery" title=" artery"> artery</a> </p> <a href="https://publications.waset.org/abstracts/9828/cell-cell-interactions-in-diseased-conditions-revealed-by-three-dimensional-and-intravital-two-photon-microscope-from-visualization-to-quantification" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9828.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">373</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">22</span> Recurrence of Papillary Thyroid Cancer with an Interval of 40 Years. Report of an Autopsy Case</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Furukawa">Satoshi Furukawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Satomu%20Morita"> Satomu Morita</a>, <a href="https://publications.waset.org/abstracts/search?q=Katsuji%20Nishi"> Katsuji Nishi</a>, <a href="https://publications.waset.org/abstracts/search?q=Masahito%20Hitosugi"> Masahito Hitosugi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A 75-year-old woman took thyroidectomy forty years previously. Enlarged masses were seen at autopsy just above and below the left clavicle. We proved the diagnosis of papillary thyroid cancer (PTC) and lung metastasis by histological examinations. The prognosis of PTC is excellent; the 10-year survival rate ranges between 85 and 99%. Lung metastases may be found in 10% of the patients with PTC. We report an unusual case of recurrence of PTC with metastasis to the lung. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=papillary%20thyroid%20cancer" title="papillary thyroid cancer">papillary thyroid cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=lung%20metastasis" title=" lung metastasis"> lung metastasis</a>, <a href="https://publications.waset.org/abstracts/search?q=autopsy" title=" autopsy"> autopsy</a>, <a href="https://publications.waset.org/abstracts/search?q=histopathological%20findings" title=" histopathological findings "> histopathological findings </a> </p> <a href="https://publications.waset.org/abstracts/13909/recurrence-of-papillary-thyroid-cancer-with-an-interval-of-40-years-report-of-an-autopsy-case" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13909.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">341</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">21</span> Free to Select vTuber Avatar eLearning Video for University Ray Tracing Course</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rex%20Hsieh">Rex Hsieh</a>, <a href="https://publications.waset.org/abstracts/search?q=Kosei%20Yamamura"> Kosei Yamamura</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Cho"> Satoshi Cho</a>, <a href="https://publications.waset.org/abstracts/search?q=Hisashi%20Sato"> Hisashi Sato</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This project took place in the fall semester of 2019 from September 2019 to February 2020. It improves upon the design of a previous vTuber based eLearning video system by correcting criticisms from students and enhancing the positive aspects of the previous system. The transformed audio which has proven to be ineffective in previous experiments was not used in this experiment. The result is videos featuring 3 avatars covering different Ray Tracing subject matters being released weekly. Students are free to pick which videos they want to watch and can also re-watch any videos they want. The students' subjective impressions of each video is recorded and analysed to help further improve the system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=vTuber" title=" vTuber"> vTuber</a>, <a href="https://publications.waset.org/abstracts/search?q=eLearning" title=" eLearning"> eLearning</a>, <a href="https://publications.waset.org/abstracts/search?q=Ray%20Tracing" title=" Ray Tracing"> Ray Tracing</a>, <a href="https://publications.waset.org/abstracts/search?q=Avatar" title=" Avatar"> Avatar</a> </p> <a href="https://publications.waset.org/abstracts/118303/free-to-select-vtuber-avatar-elearning-video-for-university-ray-tracing-course" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/118303.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">188</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">20</span> Utility Analysis of API Economy Based on Multi-Sided Platform Markets Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mami%20Sugiura">Mami Sugiura</a>, <a href="https://publications.waset.org/abstracts/search?q=Shinichi%20Arakawa"> Shinichi Arakawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Masayuki%20Murata"> Masayuki Murata</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Imai"> Satoshi Imai</a>, <a href="https://publications.waset.org/abstracts/search?q=Toru%20Katagiri"> Toru Katagiri</a>, <a href="https://publications.waset.org/abstracts/search?q=Motoyoshi%20Sekiya"> Motoyoshi Sekiya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> API (Application Programming Interface) economy, where many participants join/interact and form the economy, is expected to increase collaboration between information services through API, and thereby, it is expected to increase market value from the service collaborations. In this paper, we introduce API evaluators, which are the activator of API economy by reviewing and/or evaluating APIs, and develop a multi-sided API economy model that formulates interactions among platform provider, API developers, consumers, and API evaluators. By obtaining the equilibrium that maximizes utility of all participants, the impact of API evaluators on the utility of participants in the API economy is revealed. Numerical results show that, with the existence of API evaluators, the number of developers and consumers increase by 1.5% and the utility of platformer increases by 2.3%. We also discuss the strategies of platform provider to maximize its utility under the existence of API evaluators. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=API%20economy" title="API economy">API economy</a>, <a href="https://publications.waset.org/abstracts/search?q=multi-sided%20markets" title=" multi-sided markets"> multi-sided markets</a>, <a href="https://publications.waset.org/abstracts/search?q=API%20evaluator" title=" API evaluator"> API evaluator</a>, <a href="https://publications.waset.org/abstracts/search?q=platform" title=" platform"> platform</a>, <a href="https://publications.waset.org/abstracts/search?q=platform%20provider" title=" platform provider"> platform provider</a> </p> <a href="https://publications.waset.org/abstracts/121189/utility-analysis-of-api-economy-based-on-multi-sided-platform-markets-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/121189.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">186</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">19</span> Difference in the Expression of CIRBP, RBM3 and HSP70 in the Myocardium and Cerebellum after Death by Hypothermi a and Carbon Monoxide Poisoning</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Furukawa">Satoshi Furukawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Satomu%20Morita"> Satomu Morita</a>, <a href="https://publications.waset.org/abstracts/search?q=Lisa%20Wingenfeld"> Lisa Wingenfeld</a>, <a href="https://publications.waset.org/abstracts/search?q=Katsuji%20Nishi"> Katsuji Nishi</a>, <a href="https://publications.waset.org/abstracts/search?q=Masahito%20Hitosugi"> Masahito Hitosugi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We studied the expression of hypoxia-related antigens (e.g., cold-inducible antigens and apoptotic antigens) in the myocardium and the cerebellumthat were obtained from individuals after death by carbon monoxide or hypothermia. The immunohistochemistry results revealed that expression of cold-inducible RNA binding protein (CIRBP) and RNA-binding protein 3 (RBM3) may be associated with hpyothermic and the hypoxic conditions. The expression of CIRBP and RBM3 in the myocardium was different from their expression in the cerebellum, especially in the Purkinje cells. The results indicate that agonal duration influences antigen expression. In the hypothermic condition, the myocardium uses more ATP since the force of the excitation-contraction coupling of the myocardium increases by more than 400% when the experimental temperature is reduced from 35°C to 25°C. The results obtained in this study indicate that physicians should pay attention to the myocardium when cooling the patient’s body to protect the brain. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carbon%20monoxide%20death" title="carbon monoxide death">carbon monoxide death</a>, <a href="https://publications.waset.org/abstracts/search?q=cerebellum" title=" cerebellum"> cerebellum</a>, <a href="https://publications.waset.org/abstracts/search?q=CIRBP" title=" CIRBP"> CIRBP</a>, <a href="https://publications.waset.org/abstracts/search?q=hypothermic%20death" title=" hypothermic death"> hypothermic death</a>, <a href="https://publications.waset.org/abstracts/search?q=myocardium" title=" myocardium"> myocardium</a>, <a href="https://publications.waset.org/abstracts/search?q=RBM3" title=" RBM3"> RBM3</a> </p> <a href="https://publications.waset.org/abstracts/13000/difference-in-the-expression-of-cirbp-rbm3-and-hsp70-in-the-myocardium-and-cerebellum-after-death-by-hypothermi-a-and-carbon-monoxide-poisoning" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13000.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">363</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">18</span> An Autopsy Case of Blunt Chest Trauma from a Traffic Accident Complicated by Chest Compression Due to Resuscitation Attempts</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Furukawa">Satoshi Furukawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Satomu%20Morita"> Satomu Morita</a>, <a href="https://publications.waset.org/abstracts/search?q=Katsuji%20Nishi"> Katsuji Nishi</a>, <a href="https://publications.waset.org/abstracts/search?q=Masahito%20Hitosugi"> Masahito Hitosugi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Coronary artery dissection leading to acute myocardial infarction after blunt chest trauma is extremely rare. A 67-year-old woman suffered blunt chest trauma following a traffic accident. The electrocardiogram revealed acute posterior ST-segment elevation and myocardial infarction and coronary angiography demonstrated acute right coronary artery dissection. Following the death of the victim an autopsy was performed after cardiopulmonary support had been carried out. In this case report, we describe the case of a woman with blunt chest trauma, who developed an acute myocardial infarction secondary to right coronary artery dissection. Although there was additional the blunt chest trauma due to chest compression, we confirmed the injury at autopsy and by histological findings. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blunt%20chest%20trauma" title="blunt chest trauma">blunt chest trauma</a>, <a href="https://publications.waset.org/abstracts/search?q=right%20coronary%20artery%20dissection" title=" right coronary artery dissection"> right coronary artery dissection</a>, <a href="https://publications.waset.org/abstracts/search?q=coronary%20angiography" title=" coronary angiography"> coronary angiography</a>, <a href="https://publications.waset.org/abstracts/search?q=autopsy" title=" autopsy"> autopsy</a>, <a href="https://publications.waset.org/abstracts/search?q=histological%20examination" title=" histological examination "> histological examination </a> </p> <a href="https://publications.waset.org/abstracts/13624/an-autopsy-case-of-blunt-chest-trauma-from-a-traffic-accident-complicated-by-chest-compression-due-to-resuscitation-attempts" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13624.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">635</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">17</span> The Role of Initiator in the Synthesis of Poly(Methyl Methacrylate)-Layered Silicate Nanocomposites through Bulk Polymerization</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tsung-Yen%20Tsai">Tsung-Yen Tsai</a>, <a href="https://publications.waset.org/abstracts/search?q=Naveen%20Bunekar"> Naveen Bunekar</a>, <a href="https://publications.waset.org/abstracts/search?q=Ming%20Hsuan%20Chang"> Ming Hsuan Chang</a>, <a href="https://publications.waset.org/abstracts/search?q=Wen-Kuang%20Wang"> Wen-Kuang Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Onda"> Satoshi Onda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The structure-property relationship and initiator effect on bulk polymerized poly(methyl methacrylate) (PMMA)–oragnomodified layered silicate nanocomposites was investigated. In this study, we used 2, 2'-azobis (4-methoxy-2,4-dimethyl valeronitrile and benzoyl peroxide initiators for bulk polymerization. The bulk polymerized nanocomposites’ morphology was investigated by X-ray diffraction and transmission electron microscopy. The type of initiator strongly influences the physiochemical properties of the polymer nanocomposite. The thermal degradation of PMMA in the presence of nanofiller was studied. 5 wt% weight loss temperature (T5d) increased as compared to pure PMMA. The peak degradation temperature increased for the nanocomposites. Differential scanning calorimetry and dynamic mechanical analysis were performed to investigate the glass transition temperature and the nature of the constrained region as the reinforcement mechanism respectively. Furthermore, the optical properties such as UV-Vis and Total Luminous Transmission of nanocomposites are examined. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=initiator" title="initiator">initiator</a>, <a href="https://publications.waset.org/abstracts/search?q=bulk%20polymerization" title=" bulk polymerization"> bulk polymerization</a>, <a href="https://publications.waset.org/abstracts/search?q=layered%20silicates" title=" layered silicates"> layered silicates</a>, <a href="https://publications.waset.org/abstracts/search?q=methyl%20methacrylate" title=" methyl methacrylate"> methyl methacrylate</a> </p> <a href="https://publications.waset.org/abstracts/94517/the-role-of-initiator-in-the-synthesis-of-polymethyl-methacrylate-layered-silicate-nanocomposites-through-bulk-polymerization" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/94517.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">292</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Instability of H2-O2-CO2 Premixed Flames on Flat Burner </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kaewpradap%20Amornrat">Kaewpradap Amornrat</a>, <a href="https://publications.waset.org/abstracts/search?q=Endo%20Takahiro"> Endo Takahiro</a>, <a href="https://publications.waset.org/abstracts/search?q=Kadowaki%20Satoshi"> Kadowaki Satoshi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The combustion of hydrogen-oxygen (H2-O2) mixtures was investigated to consider the reduction of carbon dioxide (CO2) and nitrogen oxide (NOx) as the greenhouse emission. Normally, the flame speed of combustion H2-O2 mixtures are very fast thus it is necessary to control the limit of mixtures with CO2 addition as H2-O2-CO2 combustion. The limit of hydrogen was set and replaced by CO2 with O2:CO2 ratio as 1:3.76, 1:4 and 1:5 for this study. In this study, the combustion of H2-O2 -CO2 on flat burner at equivalence ratio =0.5 was investigated for 10, 15 and 20 L/min of flow rate mixtures. When the ratio of CO2 increases, the power spectral density is lower, the size of attractor and cellular flame become larger because the decrease of hydrogen replaced by CO2 affects the diffusive-thermal instability. Moreover, the flow rate mixtures increases, the power spectral density increases, the size of reconstructed attractor and cell size become smaller due to decreasing of instability. The results show that the variation of CO2 and mixture flow rate affects the instability of cellular premixed flames on flat burner. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=instability" title="instability">instability</a>, <a href="https://publications.waset.org/abstracts/search?q=H2-O2-CO2%20combustion" title=" H2-O2-CO2 combustion"> H2-O2-CO2 combustion</a>, <a href="https://publications.waset.org/abstracts/search?q=flat%20burner" title=" flat burner"> flat burner</a>, <a href="https://publications.waset.org/abstracts/search?q=diffusive-thermal%20instability" title=" diffusive-thermal instability"> diffusive-thermal instability</a> </p> <a href="https://publications.waset.org/abstracts/17224/instability-of-h2-o2-co2-premixed-flames-on-flat-burner" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17224.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">361</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> A Method for Consensus Building between Teachers and Learners in a Value Co-Creative Learning Service</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ryota%20Sugino">Ryota Sugino</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Mizoguchi"> Satoshi Mizoguchi</a>, <a href="https://publications.waset.org/abstracts/search?q=Koji%20Kimita"> Koji Kimita</a>, <a href="https://publications.waset.org/abstracts/search?q=Keiichi%20Muramatsu"> Keiichi Muramatsu</a>, <a href="https://publications.waset.org/abstracts/search?q=Tatsunori%20Matsui"> Tatsunori Matsui</a>, <a href="https://publications.waset.org/abstracts/search?q=Yoshiki%20Shimomura"> Yoshiki Shimomura</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Improving added value and productivity of services entails improving both value-in-exchange and value-in-use. Value-in-use is realized by value co-creation, where providers and receivers create value together. In higher education services, value-in-use comes from learners achieving learning outcomes (e.g., knowledge and skills) that are consistent with their learning goals. To enhance the learning outcomes of a learner, it is necessary to enhance and utilize the abilities of the teacher along with the abilities of the learner. To do this, however, the learner and the teacher need to build a consensus about their respective roles. Teachers need to provide effective learning content; learners need to choose the appropriate learning strategies by using the learning content through consensus building. This makes consensus building an important factor in value co-creation. However, methods to build a consensus about their respective roles may not be clearly established, making such consensus difficult. In this paper, we propose some strategies for consensus building between a teacher and a learner in value co-creation. We focus on a teacher and learner co-design and propose an analysis method to clarify a collaborative design process to realize value co-creation. We then analyze some counseling data obtained from a university class. This counseling aimed to build a consensus for value-in-use, learning outcomes, and learning strategies between the teacher and the learner. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=consensus%20building" title="consensus building">consensus building</a>, <a href="https://publications.waset.org/abstracts/search?q=value%20co-creation" title=" value co-creation"> value co-creation</a>, <a href="https://publications.waset.org/abstracts/search?q=higher%20education" title=" higher education"> higher education</a>, <a href="https://publications.waset.org/abstracts/search?q=learning%20service" title=" learning service"> learning service</a> </p> <a href="https://publications.waset.org/abstracts/38414/a-method-for-consensus-building-between-teachers-and-learners-in-a-value-co-creative-learning-service" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38414.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">303</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Autopsy-Based Study of Abdominal Traffic Trauma Death after Emergency Room Arrival</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Furukawa">Satoshi Furukawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Satomu%20Morita"> Satomu Morita</a>, <a href="https://publications.waset.org/abstracts/search?q=Katsuji%20Nishi"> Katsuji Nishi</a>, <a href="https://publications.waset.org/abstracts/search?q=Masahito%20Hitosugi"> Masahito Hitosugi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We experience the autopsy cases that the deceased was alive in emergency room on arrival. Bleeding is the leading cause of preventable death after injury. This retrospective study aimed to characterize opportunities for performance improvement identified in patients who died from traffic trauma and were considered by the quality improvement of education system. The Japan Advanced Trauma Evaluation and Care (JATEC) education program was introduced in 2002. We focused the abdominal traffic trauma injury. An autopsy-based cross-sectional study conducted. A purposive sampling technique was applied to select the study sample of 41 post-mortems of road traffic accident between April 1999 and March 2014 subjected to medico-legal autopsy at the department of Forensic Medicine, Shiga University of Medical Science. 16 patients (39.0%) were abdominal trauma injury. The mean period of survival after meet with accident was 13.5 hours, compared abdominal trauma death was 27.4 hours longer. In road traffic accidents, the most injured abdominal organs were liver followed by mesentery. We thought delayed treatment was associated with immediate diagnostic imaging, and so expected to expand trauma management examination. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=abdominal%20traffic%20trauma" title="abdominal traffic trauma">abdominal traffic trauma</a>, <a href="https://publications.waset.org/abstracts/search?q=preventable%20death" title=" preventable death"> preventable death</a>, <a href="https://publications.waset.org/abstracts/search?q=autopsy" title=" autopsy"> autopsy</a>, <a href="https://publications.waset.org/abstracts/search?q=emergency%20medicine" title=" emergency medicine"> emergency medicine</a> </p> <a href="https://publications.waset.org/abstracts/14459/autopsy-based-study-of-abdominal-traffic-trauma-death-after-emergency-room-arrival" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14459.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">453</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> The Social Conflicts and Evaluation of Times Square, Middletown Manhattan District in Development Since the Inceptive Point</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Seung%20Oh">Seung Oh</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Okada"> Satoshi Okada</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study is information-intensive research that provides insight from the factual history, social perception, and robust ideas derived from the social conflict in the most progressively thriving district in the world, Times Square. The case study provides the socio-environmental setup since the Inceptive Point of the development, the Great Depression, the history archives, and evaluation based on the master-level journals as standard. The Great Depression invited macro-sized changes, including financial systems, to raise fluidity by gutting off the debt limit by the gold value, organizing the labor, and social problems in the major cities. The locality of Times Square was implemented by the socio-political changes, overturning ownerships of properties, including theaters, delocalizing tourism, and re-entering the labors with organizations through infrastructure projects and civil activities for minorities and preservations amid the progressive developments over time. Naturally, chasing the media for factual research before and after Inceptive Points. Times Square is understood not just the ‘tower with subway’ progression but also social conflicts raised for adjustment for civil rights, preservations, and progression to deliver the environmental background to trigger the 42nd Street Development (42DP) in the 1990s. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=development" title="development">development</a>, <a href="https://publications.waset.org/abstracts/search?q=district" title=" district"> district</a>, <a href="https://publications.waset.org/abstracts/search?q=progressive" title=" progressive"> progressive</a>, <a href="https://publications.waset.org/abstracts/search?q=preservation" title=" preservation"> preservation</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20conflict" title=" social conflict"> social conflict</a>, <a href="https://publications.waset.org/abstracts/search?q=value%20chasing" title=" value chasing"> value chasing</a> </p> <a href="https://publications.waset.org/abstracts/184354/the-social-conflicts-and-evaluation-of-times-square-middletown-manhattan-district-in-development-since-the-inceptive-point" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184354.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">72</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Developing Value Chain of Synthetic Methane for Net-zero Carbon City Gas Supply in Japan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ryota%20Kuzuki">Ryota Kuzuki</a>, <a href="https://publications.waset.org/abstracts/search?q=Mitsuhiro%20Kohara"> Mitsuhiro Kohara</a>, <a href="https://publications.waset.org/abstracts/search?q=Noboru%20Kizuki"> Noboru Kizuki</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Yoshida"> Satoshi Yoshida</a>, <a href="https://publications.waset.org/abstracts/search?q=Hidetaka%20Hirai"> Hidetaka Hirai</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuta%20Nezasa"> Yuta Nezasa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> About fifty years have passed since Japan's gas supply industry became the first in the world to switch from coal and oil to LNG as a city gas feedstock. Since the Japanese government target of net-zero carbon emission in 2050 was announced in October 2020, it has now entered a new era of challenges to commit to the requirement for decarbonization. This paper describes the situation that synthetic methane, produced from renewable energy-derived hydrogen and recycled carbon, is a promising national policy of transition toward net-zero society. In November 2020, the Japan Gas Association announced the 'Carbon Neutral Challenge 2050' as a vision to contribute to the decarbonization of society by converting the city gas supply to carbon neutral. The key technologies is methanation. This paper shows that methanation is a realistic solution to contribute to the decarbonization of the whole country at a lower social cost, utilizing the supply chain that already exists, from LNG plants to burner chips. The challenges during the transition period (2030-2050), as CO2 captured from exhaust of thermal power plants and industrial factories are expected to be used, it is proposed that a system of guarantee of origin (GO) for H2 and CO2 should be established and harmonize international rules for calculating and allocating greenhouse gas emissions in the supply chain, a platform is also needed to manage tracking information on certified environmental values. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=synthetic%20methane" title="synthetic methane">synthetic methane</a>, <a href="https://publications.waset.org/abstracts/search?q=recycled%20carbon%20fuels" title=" recycled carbon fuels"> recycled carbon fuels</a>, <a href="https://publications.waset.org/abstracts/search?q=methanation" title=" methanation"> methanation</a>, <a href="https://publications.waset.org/abstracts/search?q=transition%20period" title=" transition period"> transition period</a>, <a href="https://publications.waset.org/abstracts/search?q=environmental%20value%20transfer%20platform" title=" environmental value transfer platform"> environmental value transfer platform</a> </p> <a href="https://publications.waset.org/abstracts/153723/developing-value-chain-of-synthetic-methane-for-net-zero-carbon-city-gas-supply-in-japan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153723.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">108</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Path-Tracking Controller for Tracked Mobile Robot on Rough Terrain</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Toshifumi%20Hiramatsu">Toshifumi Hiramatsu</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Morita"> Satoshi Morita</a>, <a href="https://publications.waset.org/abstracts/search?q=Manuel%20Pencelli"> Manuel Pencelli</a>, <a href="https://publications.waset.org/abstracts/search?q=Marta%20Niccolini"> Marta Niccolini</a>, <a href="https://publications.waset.org/abstracts/search?q=Matteo%20Ragaglia"> Matteo Ragaglia</a>, <a href="https://publications.waset.org/abstracts/search?q=Alfredo%20Argiolas"> Alfredo Argiolas</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Automation technologies for agriculture field are needed to promote labor-saving. One of the most relevant problems in automated agriculture is represented by controlling the robot along a predetermined path in presence of rough terrain or incline ground. Unfortunately, disturbances originating from interaction with the ground, such as slipping, make it quite difficult to achieve the required accuracy. In general, it is required to move within 5-10 cm accuracy with respect to the predetermined path. Moreover, lateral velocity caused by gravity on the incline field also affects slipping. In this paper, a path-tracking controller for tracked mobile robots moving on rough terrains of incline field such as vineyard is presented. The controller is composed of a disturbance observer and an adaptive controller based on the kinematic model of the robot. The disturbance observer measures the difference between the measured and the reference yaw rate and linear velocity in order to estimate slip. Then, the adaptive controller adapts “virtual” parameter of the kinematics model: Instantaneous Centers of Rotation (ICRs). Finally, target angular velocity reference is computed according to the adapted parameter. This solution allows estimating the effects of slip without making the model too complex. Finally, the effectiveness of the proposed solution is tested in a simulation environment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=the%20agricultural%20robot" title="the agricultural robot">the agricultural robot</a>, <a href="https://publications.waset.org/abstracts/search?q=autonomous%20control" title=" autonomous control"> autonomous control</a>, <a href="https://publications.waset.org/abstracts/search?q=path-tracking%20control" title=" path-tracking control"> path-tracking control</a>, <a href="https://publications.waset.org/abstracts/search?q=tracked%20mobile%20robot" title=" tracked mobile robot"> tracked mobile robot</a> </p> <a href="https://publications.waset.org/abstracts/98362/path-tracking-controller-for-tracked-mobile-robot-on-rough-terrain" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98362.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">172</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Effect of Retention Time on Kitchen Wastewater Treatment Using Mixed Algal-Bacterial Consortia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Keerthi%20Katam">Keerthi Katam</a>, <a href="https://publications.waset.org/abstracts/search?q=Abhinav%20B.%20Tirunaghari"> Abhinav B. Tirunaghari</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinod%20Vadithya"> Vinod Vadithya</a>, <a href="https://publications.waset.org/abstracts/search?q=Toshiyuki%20Shimizu"> Toshiyuki Shimizu</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Soda"> Satoshi Soda</a>, <a href="https://publications.waset.org/abstracts/search?q=Debraj%20Bhattacharyya"> Debraj Bhattacharyya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Researchers worldwide are increasingly focusing on the removal of carbon and nutrient from wastewater using algal-bacterial hybrid systems. Algae produce oxygen during photosynthesis, which is taken up by heterotrophic bacteria for mineralizing organic carbon to carbon dioxide. This phenomenon reduces the net mechanical aeration requirement of aerobic biological wastewater treatment processes. Consequently, the treatment cost is also reduced. Microalgae also participate in the treatment process by taking up nutrient (N, P) from wastewater. Algal biomass, if harvested, can generate value-added by-products. The aim of the present study was to compare the performance of two systems - System A (mixed microalgae and bacteria) and System B (diatoms and bacteria) in treating kitchen wastewater (KWW). The test reactors were operated at five different solid retention times (SRTs) -2, 4, 6, 8, and 10-days in draw-and-fill mode. The KWW was collected daily from the dining hall-kitchen area of the Indian Institute of Technology Hyderabad. The influent and effluent samples were analyzed for total organic carbon (TOC), total nitrogen (TN) using TOC-L analyzer. A colorimetric method was used to analyze anionic surfactant. Phosphorus (P) and chlorophyll were measured by following standard methods. The TOC, TN, and P of KWW were in the range of 113.5 to 740 mg/L, 2 to 22.8 mg/L, and 1 to 4.5 mg/L, respectively. Both the systems gave similar results with 85% of TOC removal and 60% of TN removal at 10-d SRT. However, the anionic surfactant removal in System A was 99% and 60% in System B. The chlorophyll concentration increased with an increase in SRT in both the systems. At 2-d SRT, no chlorophyll was observed in System B, whereas 0.5 mg/L was observed in System A. At 10-d SRT, the chlorophyll concentration in System A was 7.5 mg/L, whereas it was 4.5 mg/L in System B. Although both the systems showed similar performance in treatment, the increase in chlorophyll concentration suggests that System A demonstrated a better algal-bacterial symbiotic relationship in treating KWW than System B. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diatoms" title="diatoms">diatoms</a>, <a href="https://publications.waset.org/abstracts/search?q=microalgae" title=" microalgae"> microalgae</a>, <a href="https://publications.waset.org/abstracts/search?q=retention%20time" title=" retention time"> retention time</a>, <a href="https://publications.waset.org/abstracts/search?q=wastewater%20treatment" title=" wastewater treatment"> wastewater treatment</a> </p> <a href="https://publications.waset.org/abstracts/117873/effect-of-retention-time-on-kitchen-wastewater-treatment-using-mixed-algal-bacterial-consortia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/117873.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">129</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> The Revival of Asakusa Entertainment Streets and Social Conflicts Since Its Inceptive Point, the Post-war Time</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Seung%20Oh">Seung Oh</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Okada"> Satoshi Okada</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Today, religious organizations that have long existed alongside local people are being challenged by social changes in the districts they control. The influence of religious organizations is declining everywhere as locals seeking diversity and economic benefits become more interested in developing projects that attract investors and increase market value instead of opting for conservation. Religions whose moral and philosophical stance rejects materialism have a limited capacity to act as agents of local development in modern society. However, in Tokyo, the city’s oldest temple, Senso-Ji played a vital role in the local development of Asakusa, as an entertainment district while nevertheless retaining the area’s traditional character, despite almost complete destruction caused by the Tokyo air raids. The temple played a vigorous role as a mediator between the community and the Tokyo Metropolitan Government as a spokesman for common interests. This research, therefore, examines the social conflicts that Senso-Ji has confronted with regard to the pressures of development of Asakusa on the one hand, and the legitimacy of perpetuating its traditional religious and cultural role in local society on the other. First, this article examines Senso-Ji’s place in society based on its location in the history of Japanese Buddhism, which existed to offer spiritual and practical help to the ordinary people, and to investigate its social legitimacy as a local stakeholder and historical institution. Second, this paper considers the impact of the social changes that Asakusa had undergone during the Meiji and Taisho eras, by examining the social conflicts and changes in the Asakusa entertainment district, taking the Tokyo Air Raids as the Inceptive Point (IP). Third, it reconsiders how Senso-Ji responded to today’s growth-oriented local developments, as proposed by Tokyo’s Metropolitan planning authorities along lines commonly seen in all cities. Studying the role of Senso-Ji in the development of Asakusa can serve as a case study to justify the involvement of religious institutions in local issues and as a useful and practical example of progressive development which nevertheless permitted conservation of traditional features, as a result of pressure from social groups in a way that may be useful for other places facing similar problems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Architecture" title="Architecture">Architecture</a>, <a href="https://publications.waset.org/abstracts/search?q=Urban%20Design" title=" Urban Design"> Urban Design</a>, <a href="https://publications.waset.org/abstracts/search?q=Urban%20Planning" title=" Urban Planning"> Urban Planning</a>, <a href="https://publications.waset.org/abstracts/search?q=Preservation" title=" Preservation"> Preservation</a>, <a href="https://publications.waset.org/abstracts/search?q=Conservation" title=" Conservation"> Conservation</a>, <a href="https://publications.waset.org/abstracts/search?q=Social%20Science" title=" Social Science"> Social Science</a> </p> <a href="https://publications.waset.org/abstracts/190736/the-revival-of-asakusa-entertainment-streets-and-social-conflicts-since-its-inceptive-point-the-post-war-time" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/190736.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">24</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Control of Biofilm Formation and Inorganic Particle Accumulation on Reverse Osmosis Membrane by Hypochlorite Washing</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Masaki%20Ohno">Masaki Ohno</a>, <a href="https://publications.waset.org/abstracts/search?q=Cervinia%20Manalo"> Cervinia Manalo</a>, <a href="https://publications.waset.org/abstracts/search?q=Tetsuji%20Okuda"> Tetsuji Okuda</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Nakai"> Satoshi Nakai</a>, <a href="https://publications.waset.org/abstracts/search?q=Wataru%20Nishijima"> Wataru Nishijima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reverse osmosis (RO) membranes have been widely used for desalination to purify water for drinking and other purposes. Although at present most RO membranes have no resistance to chlorine, chlorine-resistant membranes are being developed. Therefore, direct chlorine treatment or chlorine washing will be an option in preventing biofouling on chlorine-resistant membranes. Furthermore, if particle accumulation control is possible by using chlorine washing, expensive pretreatment for particle removal can be removed or simplified. The objective of this study was to determine the effective hypochlorite washing condition required for controlling biofilm formation and inorganic particle accumulation on RO membrane in a continuous flow channel with RO membrane and spacer. In this study, direct chlorine washing was done by soaking fouled RO membranes in hypochlorite solution and fluorescence intensity was used to quantify biofilm on the membrane surface. After 48 h of soaking the membranes in high fouling potential waters, the fluorescence intensity decreased to 0 from 470 using the following washing conditions: 10 mg/L chlorine concentration, 2 times/d washing interval, and 30 min washing time. The chlorine concentration required to control biofilm formation decreased as the chlorine concentration (0.5–10 mg/L), the washing interval (1–4 times/d), or the washing time (1–30 min) increased. For the sample solutions used in the study, 10 mg/L chlorine concentration with 2 times/d interval, and 5 min washing time was required for biofilm control. The optimum chlorine washing conditions obtained from soaking experiments proved to be applicable also in controlling biofilm formation in continuous flow experiments. Moreover, chlorine washing employed in controlling biofilm with suspended particles resulted in lower amounts of organic (0.03 mg/cm<sup>2</sup>) and inorganic (0.14 mg/cm<sup>2</sup>) deposits on the membrane than that for sample water without chlorine washing (0.14 mg/cm<sup>2</sup> and 0.33 mg/cm<sup>2</sup>, respectively). The amount of biofilm formed was 79% controlled by continuous washing with 10 mg/L of free chlorine concentration, and the inorganic accumulation amount decreased by 58% to levels similar to that of pure water with kaolin (0.17 mg/cm<sup>2</sup>) as feed water. These results confirmed the acceleration of particle accumulation due to biofilm formation, and that the inhibition of biofilm growth can almost completely reduce further particle accumulation. In addition, effective hypochlorite washing condition which can control both biofilm formation and particle accumulation could be achieved. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=reverse%20osmosis" title="reverse osmosis">reverse osmosis</a>, <a href="https://publications.waset.org/abstracts/search?q=washing%20condition%20optimization" title=" washing condition optimization"> washing condition optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=hypochlorous%20acid" title=" hypochlorous acid"> hypochlorous acid</a>, <a href="https://publications.waset.org/abstracts/search?q=biofouling%20control" title=" biofouling control"> biofouling control</a> </p> <a href="https://publications.waset.org/abstracts/36473/control-of-biofilm-formation-and-inorganic-particle-accumulation-on-reverse-osmosis-membrane-by-hypochlorite-washing" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36473.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">352</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Controlling Shape and Position of Silicon Micro-nanorolls Fabricated using Fine Bubbles during Anodization</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yodai%20Ashikubo">Yodai Ashikubo</a>, <a href="https://publications.waset.org/abstracts/search?q=Toshiaki%20Suzuki"> Toshiaki Suzuki</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Kouya"> Satoshi Kouya</a>, <a href="https://publications.waset.org/abstracts/search?q=Mitsuya%20Motohashi"> Mitsuya Motohashi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Functional microstructures such as wires, fins, needles, and rolls are currently being applied to variety of high-performance devices. Under these conditions, a roll structure (silicon micro-nanoroll) was formed on the surface of the silicon substrate via fine bubbles during anodization using an extremely diluted hydrofluoric acid (HF + H₂O). The as-formed roll had a microscale length and width of approximately 1 µm. The number of rolls was 3-10 times and the thickness of the film forming the rolls was about 10 nm. Thus, it is promising for applications as a distinct device material. These rolls functioned as capsules and/or pipelines. To date, number of rolls and roll length have been controlled by anodization conditions. In general, controlling the position and roll winding state is required for device applications. However, it has not been discussed. Grooves formed on silicon surface before anodization might be useful control the bubbles. In this study, we investigated the effect of the grooves on the position and shape of the roll. The surfaces of the silicon wafers were anodized. The starting material was p-type (100) single-crystalline silicon wafers. The resistivity of the wafer is 5-20 ∙ cm. Grooves were formed on the surface of the substrate before anodization using sandpaper and diamond pen. The average width and depth of the grooves were approximately 1 µm and 0.1 µm, respectively. The HF concentration {HF/ (HF + C₂H5OH + H₂O)} was 0.001 % by volume. The C2H5OH concentration {C₂H5OH/ (HF + C₂H5OH + H₂O)} was 70 %. A vertical single-tank cell and Pt cathode were used for anodization. The silicon roll was observed by field-emission scanning electron microscopy (FE-SEM; JSM-7100, JEOL). The atomic bonding state of the rolls was evaluated using X-ray photoelectron spectroscopy (XPS; ESCA-3400, Shimadzu). For straight groove, the rolls were formed along the groove. This indicates that the orientation of the rolls can be controlled by the grooves. For lattice-like groove, the rolls formed inside the lattice and along the long sides. In other words, the aspect ratio of the lattice is very important for the roll formation. In addition, many rolls were formed and winding states were not uniform when the lattice size is too large. On the other hand, no rolls were formed for small lattice. These results indicate that there is the optimal size of lattice for roll formation. In the future, we are planning on formation of rolls using groove formed by lithography technique instead of sandpaper and the pen. Furthermore, the rolls included nanoparticles will be formed for nanodevices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=silicon%20roll" title="silicon roll">silicon roll</a>, <a href="https://publications.waset.org/abstracts/search?q=anodization" title=" anodization"> anodization</a>, <a href="https://publications.waset.org/abstracts/search?q=fine%20bubble" title=" fine bubble"> fine bubble</a>, <a href="https://publications.waset.org/abstracts/search?q=microstructure" title=" microstructure"> microstructure</a> </p> <a href="https://publications.waset.org/abstracts/192444/controlling-shape-and-position-of-silicon-micro-nanorolls-fabricated-using-fine-bubbles-during-anodization" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192444.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">20</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Effect of Institutional Structure on Project Managers Performance in Construction Projects: A Case Study in Nigeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ebuka%20Valentine%20Iroha">Ebuka Valentine Iroha</a>, <a href="https://publications.waset.org/abstracts/search?q=Tsunemi%20Watanabe"> Tsunemi Watanabe</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Tsuchiya"> Satoshi Tsuchiya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Project management practices play an important role in construction project performance and are one of project managers' essential key performance indicators. Previous studies have explored the poor performance of the construction industry, with project delays and cost overruns identified to contribute largely to numerous abandoned projects. These challenges are attributed to insufficient project management practices and a lack of utilization of project managers. The actual causes of inadequate project management practices and underutilization of project managers have been rarely discussed. This study tends to bridge the gap by identifying and assessing the actual causes of insufficient project management practices and underutilization of project managers. This study differs from past studies investigating the causes of poor performance by using institutional analysis methods to identify and analyze the factors influencing project management practices and proper utilization of project managers. Based on a comprehensive literature review, this study identified some factors embedded in the construction industry that influence the institutional environment and weaken the laws and regulations. These factors were used as the basis for semi-structured interview questions to investigate their impacts on project management practices and project managers. The data collected were coded into a four-level framework for institutional analysis. This method was used to analyze the interrelationships between the identified embedded factors, institutional laws and regulations, and construction organizations to understand how these influences result in the underutilization of project managers. The study found that the underutilization of project managers consists of two subsystems, including underutilization and lowering commitment. The first subsystem, corruption, political influence, religious and tribal discrimination, and organizational culture, were found to affect the institutional structure. These embedded factors weaken the industry’s governance mechanism, forcing project managers to prioritize corrupt practices over project demands. The ineffectiveness of the existing laws and regulations worsens the situation, supporting unfair working conditions and contributing to the underperformance of project managers. This situation leads to the development of the second subsystem, which is characterized by a lack of opportunities for career development and minimal incentives within construction organizations. The findings provide significant potential for addressing systemic challenges in the construction industry, particularly the underutilization of project managers and enhancing organizational support measures to improve project management practices and mitigate the adverse effects of corruption. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=construction%20industry" title="construction industry">construction industry</a>, <a href="https://publications.waset.org/abstracts/search?q=project%20management" title=" project management"> project management</a>, <a href="https://publications.waset.org/abstracts/search?q=poor%20performance" title=" poor performance"> poor performance</a>, <a href="https://publications.waset.org/abstracts/search?q=embedded%20factors" title=" embedded factors"> embedded factors</a>, <a href="https://publications.waset.org/abstracts/search?q=project%20managers%20underutilization" title=" project managers underutilization"> project managers underutilization</a> </p> <a href="https://publications.waset.org/abstracts/188601/effect-of-institutional-structure-on-project-managers-performance-in-construction-projects-a-case-study-in-nigeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188601.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">39</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Challenges for Competency-Based Learning Design in Primary School Mathematics in Mozambique</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Kusaka">Satoshi Kusaka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The term ‘competency’ is attracting considerable scholarly attention worldwide with the advance of globalization in the 21st century and with the arrival of a knowledge-based society. In the current world environment, familiarity with varied disciplines is regarded to be vital for personal success. The idea of a competency-based educational system was mooted by the ‘Definition and Selection of Competencies (DeSeCo)’ project that was conducted by the Organization for Economic Cooperation and Development (OECD). Further, attention to this topic is not limited to developed countries; it can also be observed in developing countries. For instance, the importance of a competency-based curriculum was mentioned in the ‘2013 Harmonized Curriculum Framework for the East African Community’, which recommends key competencies that should be developed in primary schools. The introduction of such curricula and the reviews of programs are actively being executed, primarily in the East African Community but also in neighboring nations. Taking Mozambique as a case in point, the present paper examines the conception of ‘competency’ as a target of frontline education in developing countries. It also aims to discover the manner in which the syllabus, textbooks and lessons, among other things, in primary-level math education are developed and to determine the challenges faced in the process. This study employs the perspective of competency-based education design to analyze how the term ‘competency’ is defined in the primary-level math syllabus, how it is reflected in the textbooks, and how the lessons are actually developed. ‘Practical competency’ is mentioned in the syllabus, and the description of the term lays emphasis on learners' ability to interactively apply socio-cultural and technical tools, which is one of the key competencies that are advocated in OECD's ‘Definition and Selection of Competencies’ project. However, most of the content of the textbooks pertains to ‘basic academic ability’, and in actual classroom practice, teachers often impart lessons straight from the textbooks. It is clear that the aptitude of teachers and their classroom routines are greatly dependent on the cultivation of their own ‘practical competency’ as it is defined in the syllabus. In other words, there is great divergence between the ‘syllabus’, which is the intended curriculum, and the content of the ‘textbooks’. In fact, the material in the textbooks should serve as the bridge between the syllabus, which forms the guideline, and the lessons, which represent the ‘implemented curriculum’. Moreover, the results obtained from this investigation reveal that the problem can only be resolved through the cultivation of ‘practical competency’ in teachers, which is currently not sufficient. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=competency" title="competency">competency</a>, <a href="https://publications.waset.org/abstracts/search?q=curriculum" title=" curriculum"> curriculum</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematics%20education" title=" mathematics education"> mathematics education</a>, <a href="https://publications.waset.org/abstracts/search?q=Mozambique" title=" Mozambique"> Mozambique</a> </p> <a href="https://publications.waset.org/abstracts/103504/challenges-for-competency-based-learning-design-in-primary-school-mathematics-in-mozambique" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/103504.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">194</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Organic Permeation Properties of Hydrophobic Silica Membranes with Different Functional Groups</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sadao%20Araki">Sadao Araki</a>, <a href="https://publications.waset.org/abstracts/search?q=Daisuke%20Gondo"> Daisuke Gondo</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Imasaka"> Satoshi Imasaka</a>, <a href="https://publications.waset.org/abstracts/search?q=Hideki%20Yamamoto"> Hideki Yamamoto</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The separation of organic compounds from aqueous solutions is a key technology for recycling valuable organic compounds and for the treatment of wastewater. The wastewater from chemical plants often contains organic compounds such as ethyl acetate (EA), methylethyl ketone (MEK) and isopropyl alcohol (IPA). In this study, we prepared hydrophobic silica membranes by a sol-gel method. We used phenyltrimethoxysilane (PhTMS), ethyltrimethoxysilan (ETMS), Propyltrimethoxysilane (PrTMS), N-butyltrimethoxysilane (BTMS), N-Hexyltrimethoxysilane (HTMS) as silica sources to introduce each functional groups on the membrane surface. Cetyltrimethyl ammonium bromide (CTAB) was used as a molecular template to create suitable pore that enable the permeation of organic compounds. These membranes with five different functional groups were characterized by SEM, FT-IR, and permporometry. Thicknesses and pore diameters of silica layer for all membrane were about 1.0 μm and about 1 nm, respectively. In other words, functional groups had an insignificant effect on the membrane thicknesses and the formation of the pore by CTAB. We confirmed the effect of functional groups on the flux and separation factor for ethyl acetate (EA), methyl ethyl ketone, acetone and 1-butanol (1-BtOH) /water mixtures. All membranes showed a high flux for ethyl acetate compared with other compounds. In particular, the hydrophobic silica membrane prepared by using BTMS showed 0.75 kg m-2 h-1 of flux for EA. For all membranes, the fluxes of organic compounds showed the large values in the order corresponding to EA > MEK > acetone > 1-BtOH. On the other hand, carbon chain length of functional groups among ETMS, PrTMS, BTMS, PrTMS and HTMS did not have a major effect on the organic flux. Although we confirmed the relationship between organic fluxes and organic molecular diameters or fugacity of organic compounds, these factors had a low correlation with organic fluxes. It is considered that these factors affect the diffusivity. Generally, permeation through membranes is based on the diffusivity and solubility. Therefore, it is deemed that organic fluxes through these hydrophobic membranes are strongly influenced by solubility. We tried to estimate the organic fluxes by Hansen solubility parameter (HSP). HSP, which is based on the cohesion energy per molar volume and is composed of dispersion forces (δd), intermolecular dipole interactions (δp), and hydrogen-bonding interactions (δh), has recently attracted attention as a means for evaluating the resolution and aggregation behavior. Evaluation of solubility for two substances can be represented by using the Ra [(MPa)1/2] value, meaning the distance of HSPs for both of substances. A smaller Ra value means a higher solubility for each substance. On the other hand, it can be estimated that the substances with large Ra value show low solubility. We established the correlation equation, which was based on Ra, of organic flux at low concentrations of organic compounds and at 295-325 K. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrophobic" title="hydrophobic">hydrophobic</a>, <a href="https://publications.waset.org/abstracts/search?q=membrane" title=" membrane"> membrane</a>, <a href="https://publications.waset.org/abstracts/search?q=Hansen%20solubility%20parameter" title=" Hansen solubility parameter"> Hansen solubility parameter</a>, <a href="https://publications.waset.org/abstracts/search?q=functional%20group" title=" functional group"> functional group</a> </p> <a href="https://publications.waset.org/abstracts/35524/organic-permeation-properties-of-hydrophobic-silica-membranes-with-different-functional-groups" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35524.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">378</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> An Empirical Analysis of Farmers Field Schools and Effect on Tomato Productivity in District Malakand Khyber Pakhtunkhwa-Pakistan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mahmood%20Iqbal">Mahmood Iqbal</a>, <a href="https://publications.waset.org/abstracts/search?q=Khalid%20Nawab"> Khalid Nawab</a>, <a href="https://publications.waset.org/abstracts/search?q=Tachibana%20Satoshi"> Tachibana Satoshi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Farmer Field School (FFS) is constantly aims to assist farmers to determine and learn about field ecology and integrated crop management. The study was conducted to examine the change in productivity of tomato crop in the study area; to determine increase in per acre yield of the crop, and find out reduction in per acre input cost. A study of tomato crop was conducted in ten villages namely Jabban, Bijligar Colony, Palonow, Heroshah, Zara Maira, Deghar Ghar, Sidra Jour, Anar Thangi, Miangano Korona and Wartair of district Malakand. From each village 15 respondents were selected randomly on the basis of identical allocation making sample size of 150 respondents. The research was based on primary as well as secondary data. Primary data was collected from farmers while secondary data were taken from Agriculture Extension Department Dargai, District Malakand. Interview schedule was planned and each farmer was interviewed personally. The study was based on comparison of cost, yield and income of tomato before and after FFS. Paired t-test and Statistical Package for Social Sciences (SPSS) was used for analysis; outcome of the study show that integrated pest management project has brought a positive change in the attitude of farmers of the project area through FFS approach. In district Malakand 66.0% of the respondents were between the age group of 31-50 years, 11.3% of respondents had primary level of education, 12.7% of middle level, 28.7% metric level, 3.3% of intermediate level and 2.0% of graduate level of education while 42.0% of respondents were illiterate and have no education. Average land holding size of farmers was 6.47 acres, cost of seed, crop protection from insect pest and crop protection from diseases was reduced by Rs. 210.67, Rs. 2584.43 and Rs. 3044.16 respectively, the cost of fertilizers and cost of farm yard manure was increased by Rs.1548.87 and Rs. 1151.40 respectively while tomato yield was increased by 1585.03 kg/acre from 7663.87 to 9248.90 kg/acre. The role of FFS initiate by integrated pest management project through department of agriculture extension for the development of agriculture was worth mentioning. It has brought enhancement in crop yield of tomato and their income through FFS approach. On the basis of results of the research studies, integrated pest management project should spread their developmental activities for maximum participation of the complete rural masses through participatory FFS approach. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=agriculture" title="agriculture">agriculture</a>, <a href="https://publications.waset.org/abstracts/search?q=Farmers%20field%20schools" title=" Farmers field schools"> Farmers field schools</a>, <a href="https://publications.waset.org/abstracts/search?q=extension%20education" title=" extension education"> extension education</a>, <a href="https://publications.waset.org/abstracts/search?q=tomato" title=" tomato"> tomato</a> </p> <a href="https://publications.waset.org/abstracts/19680/an-empirical-analysis-of-farmers-field-schools-and-effect-on-tomato-productivity-in-district-malakand-khyber-pakhtunkhwa-pakistan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19680.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">613</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Sugar-Induced Stabilization Effect of Protein Structure </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mitsuhiro%20Hirai">Mitsuhiro Hirai</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Ajito"> Satoshi Ajito</a>, <a href="https://publications.waset.org/abstracts/search?q=Nobutaka%20Shimizu"> Nobutaka Shimizu</a>, <a href="https://publications.waset.org/abstracts/search?q=Noriyuki%20Igarashi"> Noriyuki Igarashi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hiroki%20Iwase"> Hiroki Iwase</a>, <a href="https://publications.waset.org/abstracts/search?q=Shinichi%20Takata"> Shinichi Takata</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sugars and polyols are known to be bioprotectants preventing such as protein denaturation and enzyme deactivation and widely used as a nontoxic additive in various industrial and medical products. The mechanism of their protective actions has been explained by specific bindings between biological components and additives, changes in solvent viscosities, and surface tension and free energy changes upon transfer of those components into additive solutions. On the other hand, some organisms having tolerances against extreme environment produce stress proteins and/or accumulate sugars in cells, which is called cryptobiosis. In particular, trehalose has been drawing attention relevant to cryptobiosis under external stress such as high or low temperature, drying, osmotic pressure, and so on. The function of cryptobiosis by trehalose has been explained relevant to the restriction of the intra-and/or-inter-molecular movement by vitrification or from the replacement of water molecule by trehalose. Previous results suggest that the structure and interaction between sugar and water are a key determinant for understanding cryptobiosis. Recently, we have shown direct evidence that the protein hydration (solvation) and structural stability against chemical and thermal denaturation significantly depend on sugar species and glycerol. Sugar and glycerol molecules tend to be preferentially or weakly excluded from the protein surface and preserved the native protein hydration shell. Due to the protective action of the protein hydration shell by those molecules, the protein structure is stabilized against chemical (guanidinium chloride) and thermal denaturation. The protective action depends on sugar species. To understand the above trend and difference in detail, it is essentially important to clarify the characteristics of solutions containing those additives. In this study, by using wide-angle X-ray scattering technique covering a wide spatial region (~3-120 Å), we have clarified structures of sugar solutions with the concentration from 5% w/w to 65% w/w. The sugars measured in the present study were monosaccharides (glucose, fructose, mannose) and disaccharides (sucrose, trehalose, maltose). Due to observed scattering data with a wide spatial resolution, we have succeeded in obtaining information on the internal structure of individual sugar molecules and on the correlation between them. Every sugar gradually shortened the average inter-molecular distance as the concentration increased. The inter-molecular interaction between sugar molecules was essentially showed an exclusive tendency for every sugar, which appeared as the presence of a repulsive correlation hole. This trend was more weakly seen for trehalose compared to other sugars. The intermolecular distance and spread of individual molecule clearly showed the dependence of sugar species. We will discuss the relation between the characteristic of sugar solution and its protective action of biological materials. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydration" title="hydration">hydration</a>, <a href="https://publications.waset.org/abstracts/search?q=protein" title=" protein"> protein</a>, <a href="https://publications.waset.org/abstracts/search?q=sugar" title=" sugar"> sugar</a>, <a href="https://publications.waset.org/abstracts/search?q=X-ray%20scattering" title=" X-ray scattering"> X-ray scattering</a> </p> <a href="https://publications.waset.org/abstracts/107304/sugar-induced-stabilization-effect-of-protein-structure" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/107304.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">156</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Membrane Permeability of Middle Molecules: A Computational Chemistry Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sundaram%20Arulmozhiraja">Sundaram Arulmozhiraja</a>, <a href="https://publications.waset.org/abstracts/search?q=Kanade%20Shimizu"> Kanade Shimizu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuta%20Yamamoto"> Yuta Yamamoto</a>, <a href="https://publications.waset.org/abstracts/search?q=Satoshi%20Ichikawa"> Satoshi Ichikawa</a>, <a href="https://publications.waset.org/abstracts/search?q=Maenaka%20Katsumi"> Maenaka Katsumi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hiroaki%20Tokiwa"> Hiroaki Tokiwa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Drug discovery is shifting from small molecule based drugs targeting local active site to middle molecules (MM) targeting large, flat, and groove-shaped binding sites, for example, protein-protein interface because at least half of all targets assumed to be involved in human disease have been classified as “difficult to drug” with traditional small molecules. Hence, MMs such as peptides, natural products, glycans, nucleic acids with various high potent bioactivities become important targets for drug discovery programs in the recent years as they could be used for ‘undruggable” intracellular targets. Cell membrane permeability is one of the key properties of pharmacodynamically active MM drug compounds and so evaluating this property for the potential MMs is crucial. Computational prediction for cell membrane permeability of molecules is very challenging; however, recent advancement in the molecular dynamics simulations help to solve this issue partially. It is expected that MMs with high membrane permeability will enable drug discovery research to expand its borders towards intracellular targets. Further to understand the chemistry behind the permeability of MMs, it is necessary to investigate their conformational changes during the permeation through membrane and for that their interactions with the membrane field should be studied reliably because these interactions involve various non-bonding interactions such as hydrogen bonding, -stacking, charge-transfer, polarization dispersion, and non-classical weak hydrogen bonding. Therefore, parameters-based classical mechanics calculations are hardly sufficient to investigate these interactions rather, quantum mechanical (QM) calculations are essential. Fragment molecular orbital (FMO) method could be used for such purpose as it performs ab initio QM calculations by dividing the system into fragments. The present work is aimed to study the cell permeability of middle molecules using molecular dynamics simulations and FMO-QM calculations. For this purpose, a natural compound syringolin and its analogues were considered in this study. Molecular simulations were performed using NAMD and Gromacs programs with CHARMM force field. FMO calculations were performed using the PAICS program at the correlated Resolution-of-Identity second-order Moller Plesset (RI-MP2) level with the cc-pVDZ basis set. The simulations clearly show that while syringolin could not permeate the membrane, its selected analogues go through the medium in nano second scale. These correlates well with the existing experimental evidences that these syringolin analogues are membrane-permeable compounds. Further analyses indicate that intramolecular -stacking interactions in the syringolin analogues influenced their permeability positively. These intramolecular interactions reduce the polarity of these analogues so that they could permeate the lipophilic cell membrane. Conclusively, the cell membrane permeability of various middle molecules with potent bioactivities is efficiently studied using molecular dynamics simulations. Insight of this behavior is thoroughly investigated using FMO-QM calculations. Results obtained in the present study indicate that non-bonding intramolecular interactions such as hydrogen-bonding and -stacking along with the conformational flexibility of MMs are essential for amicable membrane permeation. These results are interesting and are nice example for this theoretical calculation approach that could be used to study the permeability of other middle molecules. This work was supported by Japan Agency for Medical Research and Development (AMED) under Grant Number 18ae0101047. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fragment%20molecular%20orbital%20theory" title="fragment molecular orbital theory">fragment molecular orbital theory</a>, <a href="https://publications.waset.org/abstracts/search?q=membrane%20permeability" title=" membrane permeability"> membrane permeability</a>, <a href="https://publications.waset.org/abstracts/search?q=middle%20molecules" title=" middle molecules"> middle molecules</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics%20simulation" title=" molecular dynamics simulation"> molecular dynamics simulation</a> </p> <a href="https://publications.waset.org/abstracts/100916/membrane-permeability-of-middle-molecules-a-computational-chemistry-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100916.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">189</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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