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href="/research/beacons/">Research beacons</a> <ul class="sectionMenu"> <li><a href="/research/beacons/advanced-materials/">Advanced materials</a></li> <li><span><a href="/research/beacons/biotechnology/">Biotechnology</a></span></li> <li><a href="/research/beacons/cancer/">Cancer</a></li> <li><a href="/research/beacons/energy/">Energy</a></li> <li><a href="/research/beacons/global-inequalities/">Global inequalities</a></li> </ul> </li> </ul> </nav> </div> </div> </div>  </header>  <article class="contentContainer">   <div class="banner-block highlights" id="d.en.930856" tabindex="-1"> <picture> <source srcset="/research/beacons/biotechnology/research-beacons-biotechnology-section-image-banner-dt.jpg" media="(min-width: 800px)" /> <img src="/research/beacons/biotechnology/research-beacons-biotechnology-section-image-banner-mobile.jpg" alt="Some alt text" /> </picture> <div class="padding"> <div class="copy-panels"> <div class="copy"> <h1>Biotechnology</h1> </div> <div role="tablist" class="panels-nav"> <span><button id="panel-1-button" type="button" role="tab" aria-selected="true" aria-controls="panel-1" data-contenttype="Tabs - banner highlights">At a glance</button></span> <span><button id="panel-2-button" type="button" role="tab" aria-selected="false" aria-controls="panel-2" tabindex="-1" data-contenttype="Tabs - banner highlights">Local and global impact</button></span> <span><button id="panel-3-button" type="button" role="tab" aria-selected="false" aria-controls="panel-3" tabindex="-1" data-contenttype="Tabs - banner highlights">Key projects</button></span> </div> <div class="panels-content"> <div id="panel-1" role="tabpanel" aria-labelledby="panel-1-button" class="panel"> <div class="highlight"> <div class="heading-copy"> <div class="heading">400+</div> <div class="copy"><p>Dedicated researchers across three Faculties. </p></div> </div> </div> <div class="highlight"> <div class="heading-copy"> <div class="heading">12</div> <div class="copy"><p>Major spin-out companies from our research.</p></div> </div> </div> <div class="highlight"> <div class="heading-copy"> <div class="heading">2019</div> <div class="copy"><p><a href="https://www.manchester.ac.uk/discover/news/mib-receives-queens-anniversary-prize-at-buckingham-palace-ceremony/">Queen's Anniversary Prize</a> for supporting strategic development of biotechnology in the UK.</p></div> </div> </div> </div> <div id="panel-2" role="tabpanel" aria-labelledby="panel-2-button" class="panel" hidden> <div class="highlight"> <div class="heading-copy"> <div class="heading">Uniquely brewed</div> <div class="copy"><p>Bringing science and artisanal brewing together to create a <a href="https://www.manchester.ac.uk/discover/news/tales-from-the-future---a-new-way-forward-for-beer-brewing/">University beer with Cloudwater Brew Co</a>. </p></div> </div> </div> <div class="highlight"> <div class="heading-copy"> <div class="heading">Access to medicine</div> <div class="copy"><p>Working with the Bill and Melinda Gates Foundation to create <a href="https://www.manchester.ac.uk/discover/magazine/opinion/equitable-access-to-medicines/">fairer access to life-saving medicines</a> across the globe. </p></div> </div> </div> </div> <div id="panel-3" role="tabpanel" aria-labelledby="panel-3-button" class="panel" hidden> <div class="highlight"> <div class="heading-copy"> <div class="heading">Innovation catalyst</div> <div class="copy"><p>Creating a supportive ecosystem for biotechnology innovation in the north-west through the <a href="https://www.manchester.ac.uk/discover/news/ibic-to-drive-economic-growth-in-northwest/">Industrial Biotechnology Innovation Catalyst</a>.</p></div> </div> </div> <div class="highlight"> <div class="heading-copy"> <div class="heading">Scaling-up</div> <div class="copy"><p>Working to scale-up sustainable manufacturing of <a href="https://www.manchester.ac.uk/discover/news/researchers-develop-a-new-approach-to-scale-up-manufacturing-of-life-saving-oligonucleotide-therapeutics/">oligonuclides to support making human therapeutics</a>. </p></div> </div> </div> <div class="highlight"> <div class="heading-copy"> <div class="heading">Stable ecosystems</div> <div class="copy"><p>Investigating how healthy <a href="https://www.manchester.ac.uk/discover/news/the-university-of-manchester-secures-major-bioscience-funding-to-harness-the-activity-of-microbiomes-for-a-more-sustainable-future/">microbial communities</a> can help maintain stable ecosystems and reach net zero.</p></div> </div> </div> </div> </div> </div> </div> </div> <div id="breadcrumb-share-container" class="row showAtDesktop">  <nav class="breadcrumbNav showAtDesktop" data-menutype="Breadcrumbs" aria-label="Breadcrumb"> <ul itemprop="breadcrumb"><li><a href="/">Home</a></li><li><a href="/research/">Research</a></li><li><a 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id="d.en.930378"></span> <h2 class="OutlineElement Ltr SCXW62194283 BCX8">Engineering biology for a sustainable world</h2> <p class="OutlineElement Ltr SCXW62194283 BCX8">As we look for ways to protect our environment and support the health of billions across the globe, we turn to nature’s own processes to provide the answers.</p> <p class="OutlineElement Ltr SCXW62194283 BCX8">Biotechnology is enabling us to find new and more sustainable ways to produce chemicals, materials, and everyday products, by understanding and harnessing biological processes and applying them at industrial scales.</p> <p class="OutlineElement Ltr SCXW62194283 BCX8">By engineering biology, we can create more environmentally friendly agricultural products, produce human therapeutics quickly and at a lower cost, and reduce carbon emissions from key industries while also divesting those industries from petrochemical feedstocks. </p> <p class="OutlineElement Ltr SCXW62194283 BCX8">Supported by the internationally recognised Manchester Institute of Biotechnology, our 400+ experts are innovating solutions to key challenges in environmental sustainability, clean energy, health, and sustainable manufacturing.  </p> <span id="d.en.930385"></span> <h2>Our research covers</h2> <div class="accordion upgrade"> <div class="accordion-item" id="d.en.930387"> <h2><button class="accordion-item-button" id="accordion-item-930387-button" aria-controls="accordion-item-930387" aria-expanded="false" data-contenttype="Accordion"><span class="text">Environmental biotechnology</span><span class="icon"></span></button></h2> <div class="accordion-item-content" id="accordion-item-930387" aria-labelledby="accordion-item-930387-button" hidden> <ul class="BulletListStyle1 SCXW43422791 BCX8"> <li class="OutlineElement Ltr SCXW43422791 BCX8" data-aria-level="1" data-aria-posinset="1" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-listid="40">Sustainable farming and managing waste safely and efficiently.  </li> <li class="OutlineElement Ltr SCXW43422791 BCX8" data-aria-level="1" data-aria-posinset="2" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-listid="40">Exploring sustainable agricultural practices in food production and the use of fertilisers and pesticides.   </li> <li class="OutlineElement Ltr SCXW43422791 BCX8" data-aria-level="1" data-aria-posinset="3" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-listid="40">Utilising bioremediation to help manage environmental pollutants and maintain a healthy world. </li> </ul> <p class="SCXW7903430 BCX8"><a href="https://www.manchester.ac.uk/research/beacons/research-highlights/?beacon=biotechnology">Discover research highlights</a></p> </div> </div> <div class="accordion-item" id="d.en.930388"> <h2><button class="accordion-item-button" id="accordion-item-930388-button" aria-controls="accordion-item-930388" aria-expanded="false" data-contenttype="Accordion"><span class="text">Industrial biotechnology</span><span class="icon"></span></button></h2> <div class="accordion-item-content" id="accordion-item-930388" aria-labelledby="accordion-item-930388-button" hidden> <ul class="BulletListStyle1 SCXW223088421 BCX8"> <li class="OutlineElement Ltr SCXW223088421 BCX8" data-aria-level="1" data-aria-posinset="4" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-listid="41">Harnessing natural processes to develop new energy sources to replace fossil fuels.   </li> <li class="OutlineElement Ltr SCXW223088421 BCX8" data-aria-level="1" data-aria-posinset="5" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-listid="41">Using waste as a feedstock to produce sustainable fuels and mitigate harmful GHG emissions.   </li> <li class="OutlineElement Ltr SCXW223088421 BCX8" data-aria-level="1" data-aria-posinset="6" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-listid="41">Supporting the government, businesses and our communities in divesting from fossil fuels.   </li> </ul> <p><a href="https://www.manchester.ac.uk/research/beacons/research-highlights/?beacon=biotechnology">Discover research highlights</a></p> </div> </div> <div class="accordion-item" id="d.en.930389"> <h2><button class="accordion-item-button" id="accordion-item-930389-button" aria-controls="accordion-item-930389" aria-expanded="false" data-contenttype="Accordion"><span class="text">Life sciences and health</span><span class="icon"></span></button></h2> <div class="accordion-item-content" id="accordion-item-930389" aria-labelledby="accordion-item-930389-button" hidden> <ul class="BulletListStyle1 SCXW141314499 BCX8"> <li class="OutlineElement Ltr SCXW141314499 BCX8" data-aria-level="1" data-aria-posinset="1" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="49">Producing medicines more efficiently without the need for harmful chemicals. </li> <li class="OutlineElement Ltr SCXW141314499 BCX8" data-aria-level="1" data-aria-posinset="2" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="49">Identifying new ways to recognise disease, accelerate diagnosis and improve patient outcomes.   </li> <li class="OutlineElement Ltr SCXW141314499 BCX8" data-aria-level="1" data-aria-posinset="3" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="49">Working collaboratively across life sciences and health communities to understand and develop new ways to improve health across the world.  </li> </ul> <p><a href="https://www.manchester.ac.uk/research/beacons/research-highlights/?beacon=biotechnology">Discover research highlights</a></p> </div> </div> <div class="accordion-item" id="d.en.930390"> <h2><button class="accordion-item-button" id="accordion-item-930390-button" aria-controls="accordion-item-930390" aria-expanded="false" data-contenttype="Accordion"><span class="text">Microbial biotechnology</span><span class="icon"></span></button></h2> <div class="accordion-item-content" id="accordion-item-930390" aria-labelledby="accordion-item-930390-button" hidden> <ul class="BulletListStyle1 SCXW229019540 BCX8"> <li class="OutlineElement Ltr SCXW229019540 BCX8" data-aria-level="1" data-aria-posinset="4" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="51">Developing sustainable, efficient and cheaper production methods for everyday products. </li> <li class="OutlineElement Ltr SCXW229019540 BCX8" data-aria-level="1" data-aria-posinset="5" data-font="Symbol" data-leveltext="" data-list-defn-props="{"335552541":1,"335559684":-2,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-listid="51">Using nature’s own mechanisms to uncover new manufacturing techniques and reduce our reliance on solvents and high energy-use processes. </li> </ul> <p><a href="https://www.manchester.ac.uk/research/beacons/research-highlights/?beacon=biotechnology">Discover research highlights</a></p> </div> </div> </div> <div class="extend-content"> <span id="d.en.930403"></span> <h2>Key institutes</h2> <div class="grid-expanding-cards columns-4 with-indicators variant-light"> <div class="cards"> <div class="card is-collapsed" id="card-930405"> <button class="card-inner js-expander" id="expander-930405-button" aria-controls="expander-930405" aria-expanded="false" data-contenttype="Grid of expanding cards"> <div class="copy"> <p class="title">Manchester Institute of Biotechnology</p> <p class="description">Interdisciplinary research institute helping to feed, fuel and heal the world</p> </div> <img class="grid-image-border" src="/research/beacons/biotechnology/MIB-about_BannerImage1400x400-(1).jpg" alt="Manchester Institute of Biotechnology" /> <div class="expand"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 13 8"><polygon class="chevron-arrow-down" points="13 1.6 11.4 0 6.5 4.8 1.6 0 0 1.6 4.9 6.4 4.9 6.4 6.5 7.9 8.1 6.4 8.1 6.4 13 1.6"/></svg></div> </button> <div class="card-expander small-image-padding" id="expander-930405" hidden>  <button class="js-collapser" tabindex="-1" aria-controls="collapser-930405" aria-expanded="false" id="collasper-930405-button"> <img src="https://assets.manchester.ac.uk/corporate/images/design/icon-close-white.svg" alt="Close" /> </button> <div class="card-expander-content reverse-row"> <img src="/research/beacons/biotechnology/Manchester-Institute-of-Biotechnology-expanded.jpg" alt="Manchester Institute of Biotechnology" class= "large-image"/> <div class="copy "> <h3>Manchester Institute of Biotechnology</h3> <ul> <li>Home to more than 40 research groups leading pioneering projects to advance our knowledge and use of biotechnology.  </li> <li>Our academics work closely and actively with businesses to solve real-world problems.  </li> <li>Our research supports strategies for the future, as well as solutions for today’s manufacturing processes.  </li> </ul> <p><a href="https://www.mib.manchester.ac.uk/">Discover more</a></p> </div> </div> </div> </div><div class="card is-collapsed" id="card-930406"> <button class="card-inner js-expander" id="expander-930406-button" aria-controls="expander-930406" aria-expanded="false" data-contenttype="Grid of expanding cards"> <div class="copy"> <p class="title">Henry Royce Institute</p> <p class="description">Challenging and stimulating innovation in advanced materials research</p> </div> <img class="grid-image-border" src="/research/beacons/biotechnology/henry-royce-institute-500x500-(1).jpg" alt="Henry Royce Institute" /> <div class="expand"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 13 8"><polygon class="chevron-arrow-down" points="13 1.6 11.4 0 6.5 4.8 1.6 0 0 1.6 4.9 6.4 4.9 6.4 6.5 7.9 8.1 6.4 8.1 6.4 13 1.6"/></svg></div> </button> <div class="card-expander small-image-padding" id="expander-930406" hidden>  <button class="js-collapser" tabindex="-1" aria-controls="collapser-930406" aria-expanded="false" id="collasper-930406-button"> <img src="https://assets.manchester.ac.uk/corporate/images/design/icon-close-white.svg" alt="Close" /> </button> <div class="card-expander-content reverse-row"> <img src="/research/beacons/biotechnology/henry-royce-expanded.jpg" alt="Henry Royce Institute" class= "large-image"/> <div class="copy "> <h3>Henry Royce Institute</h3> <ul> <li>Enabling advanced materials research collaboration and strategy.  </li> <li>Driving industrial collaboration and providing access to the latest facilities.</li> <li>Fostering material science skills development, training and outreach.  </li> </ul> <p><a href="https://www.royce.ac.uk/">Discover more</a></p> </div> </div> </div> </div><div class="card is-collapsed" id="card-930407"> <button class="card-inner js-expander" id="expander-930407-button" aria-controls="expander-930407" aria-expanded="false" data-contenttype="Grid of expanding cards"> <div class="copy"> <p class="title">The Firs Environmental Research Station</p> <p class="description">State-of-the-art facilities for environmental research and monitoring</p> </div> <img class="grid-image-border" src="/research/beacons/biotechnology/firs-(1).jpg" alt="Firs Environmental Research Station" /> <div class="expand"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 13 8"><polygon class="chevron-arrow-down" points="13 1.6 11.4 0 6.5 4.8 1.6 0 0 1.6 4.9 6.4 4.9 6.4 6.5 7.9 8.1 6.4 8.1 6.4 13 1.6"/></svg></div> </button> <div class="card-expander small-image-padding" id="expander-930407" hidden>  <button class="js-collapser" tabindex="-1" aria-controls="collapser-930407" aria-expanded="false" id="collasper-930407-button"> <img src="https://assets.manchester.ac.uk/corporate/images/design/icon-close-white.svg" alt="Close" /> </button> <div class="card-expander-content reverse-row"> <img src="/research/beacons/biotechnology/Firs-Environmental-Research-Station-expanded.jpg" alt="Firs Environmental Research Station" class= "large-image"/> <div class="copy "> <h3>The Firs Environmental Research Station</h3> <ul> <li>Gives our researchers access to 14 climate controlled growing compartments.</li> <li>Produces a range of different environments from tropical to sub-arctic.</li> <li>Helps to replicate conditions from around the world and conditions resulting from climate change.</li> </ul> <p><a href="https://www.ees.manchester.ac.uk/research/facilities/firs-environmental-research-station/">Discover more</a></p> </div> </div> </div> </div><div class="card is-collapsed" id="card-943840"> <button class="card-inner js-expander" id="expander-943840-button" aria-controls="expander-943840" aria-expanded="false" data-contenttype="Grid of expanding cards"> <div class="copy"> <p class="title">Manchester Environmental Research Institute</p> <p class="description">Multi-disciplinary research facility to address key environmental challenges</p> </div> <img class="grid-image-border" src="/research/beacons/biotechnology/Events_ImagePromo500x298-(2).jpg" alt="Manchester Environmental Research Institute event" /> <div class="expand"><svg version="1.1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 13 8"><polygon class="chevron-arrow-down" points="13 1.6 11.4 0 6.5 4.8 1.6 0 0 1.6 4.9 6.4 4.9 6.4 6.5 7.9 8.1 6.4 8.1 6.4 13 1.6"/></svg></div> </button> <div class="card-expander small-image-padding" id="expander-943840" hidden>  <button class="js-collapser" tabindex="-1" aria-controls="collapser-943840" aria-expanded="false" id="collasper-943840-button"> <img src="https://assets.manchester.ac.uk/corporate/images/design/icon-close-white.svg" alt="Close" /> </button> <div class="card-expander-content reverse-row"> <img src="/research/beacons/biotechnology/Manchester-Environmental-Research-Institute-expanded.jpg" alt="Manchester Environmental Research Institute event" class= "large-image"/> <div class="copy "> <h3>Manchester Environmental Research Institute</h3> <ul> <li>Established in 2018 – bringing together experts to innovate solutions to the challenges faced with a changing environment.</li> <li>Research addresses effects of environmental change on healthcare, food security, water resources and energy production.</li> </ul> <p class="ListContainerWrapper SCXW56068592 BCX8"><a href="https://www.meri.manchester.ac.uk/">Discover more</a> </p> </div> </div> </div> </div> </div> </div> <div class="flex-grid"> <div class="grid-cell width-full" id="d.en.952934" tabindex="-1"> <div class="card copy-image"> <div class="padding"> <div class="copy first-heading-h3"> <h3>Tomorrow Labs</h3> <p>Discover our cutting edge facilities where you can access the expertise and equipment you need to address your biotechnology research needs.</p> <p class="cta"> <a class="primary" data-ctatype="Landing page - primary" href="https://www.scieng.manchester.ac.uk/tomorrowlabs/welcome/discover-tomorrow-labs">Find out more<span class="screenreader"> about Tomorrow Labs</span></a> </p> </div> </div> <img class="lazy2" src="data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 500 298'%3E%3C/svg%3E" data-src="/research/beacons/biotechnology/bioprinting.jpg" alt="Tomorrow Labs " /> <noscript><img src="/research/beacons/biotechnology/bioprinting.jpg" width="500" height="298" alt="Tomorrow Labs " /></noscript> </div> </div> </div> <div class="singleVertPadding"> <div class="newsTitleContainer"> <h2><a href="https://www.manchester.ac.uk/about/news/?h=1&t=biotechnology">News</a></h2> <a class="all" href="https://www.manchester.ac.uk/about/news/?h=1&t=biotechnology">See all news</a></div> <div class="carousel-wrapper no-descriptions"> <a href="#" class="carousel-prev" title="Show previous news story"><span class="screenreader">Show previous news story</span></a> <a href="#" class="carousel-next" title="Show next news story"><span class="screenreader">Show next news story</span></a> <div class="carousel"> <div class="slide"> <a href="https://www.manchester.ac.uk/about/news/the-university-of-manchester-partners-in-initiative-to-accelerate-diagnostic-innovation/"> <span class="image-container"> <img class="lazynewsx lazy2" src="data:image/gif;base64,R0lGODlhAQABAIAAAPT09AAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" width="360" height="215" data-original="https://content.presspage.com/uploads/1369/91e51294-ca65-4480-9208-909ba4018e75/500_cadda-stockimage.jpg?10000" data-src="https://content.presspage.com/uploads/1369/91e51294-ca65-4480-9208-909ba4018e75/500_cadda-stockimage.jpg?10000" alt="" /> <noscript><img src="https://content.presspage.com/uploads/1369/91e51294-ca65-4480-9208-909ba4018e75/500_cadda-stockimage.jpg?10000" width="360" height="215" alt="" /></noscript> </span> <div class="carouselContent"> <h3 class="largeTitle">The University of Manchester partners in £8.2 million initiative to accelerate diagnostic innovation</h3> <p class="description">The project, led by the University of Kent, and including The University of Manchester, and University College London (UCL), will address the development gap in the diagnostics innovation ecosystem.Accelerating Innovation in DiagnosticsDiagnostics play a vital role in healthcare, informing approximately 70% of clinical decisions. From detecting diseases to enabling precision medicine, diagnostics have the potential to save lives, reduce healthcare costs, and improve global health outcomes. The COVID-19 pandemic highlighted the importance of rapid diagnostic innovation, showcasing how timely diagnostics can mitigate public health crises and support economic resilience.However, over 80% of UK companies developing diagnostics are small and medium enterprises (SMEs), which often face significant barriers in accessing the technical expertise, resources, and infrastructure needed to bring new products to market. CADDA seeks to address these challenges by fostering a collaborative, multidisciplinary environment that bridges academia, industry, the NHS, and regulatory bodies.A National Effort with Global ImpactThe CADDA initiative will harness the strengths of leading institutions in the North and South of England to ensure benefits are distributed across the UK. By providing SMEs with access to essential knowledge, infrastructure, and resources, CADDA will help overcome the fragmentation in the diagnostics sector that often delays innovation and increases costs.Key stakeholders, including national and local NHS trusts, will be integrated into every aspect of the project to ensure that new diagnostic tools are clinically relevant, ethically sound, and compliant with regulatory standards. This coordinated approach will deliver diagnostics that meet the highest quality standards while addressing urgent healthcare needs.Broader Benefits for Society and the EconomyIn addition to advancing healthcare, CADDA will enhance animal health, strengthen biosecurity, and drive economic benefits for the UK. By enabling SMEs to overcome barriers to innovation, CADDA will support regional growth and position the UK as a global leader in diagnostic development.Professor Mark Smales, from the University of Kent and co-Director of CADDA, highlighted the initiative’s transformative potential: “Through coalescing and harnessing the breadth of world class expertise in the UK across universities and research institutes, industry, SMEs, clinicians/end users, regulators and investors, we will be able to bring high quality innovative diagnostics faster to market; our medical community will be able to diagnose medical issues and save lives; and animal health and security will be enhanced. This will collectively provide wider societal and economic benefits to the UK.”Professor Kathy Kotiadis, also from the University of Kent and co-Director of CADDA, added: “We are excited to support the business development needs of the diagnostics sector. SMEs often face significant barriers to expansion due to limited access to expertise and information, hindering their ability to introduce new diagnostics to the market, a gap CADDA will fill.”</p> </div> </a> </div> <div class="slide"> <a href="https://www.manchester.ac.uk/about/news/innovative-enzyme-breakthrough-could-transform-drug-and-chemical-manufacturing/"> <span class="image-container"> <img class="lazynewsx lazy2" src="data:image/gif;base64,R0lGODlhAQABAIAAAPT09AAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" width="360" height="215" data-original="https://content.presspage.com/uploads/1369/01f34af1-17ab-4dfb-abf1-096e583889be/500_shutterstock-178384334.jpg?10000" data-src="https://content.presspage.com/uploads/1369/01f34af1-17ab-4dfb-abf1-096e583889be/500_shutterstock-178384334.jpg?10000" alt="" /> <noscript><img src="https://content.presspage.com/uploads/1369/01f34af1-17ab-4dfb-abf1-096e583889be/500_shutterstock-178384334.jpg?10000" width="360" height="215" alt="" /></noscript> </span> <div class="carouselContent"> <h3 class="largeTitle">Innovative enzyme breakthrough could transform drug and chemical manufacturing</h3> <p class="description">Published today (15 January 2025) in Nature, this breakthrough centres on a process called nucleophilic aromatic substitution (SNAr), a class of transformation that is widely used across the chemical industries including pharmaceuticals and agrochemicals. This enzymatic process offers a greener, more efficient alternative to traditional chemical synthesis.Catalysing chemistrySNAr reactions are crucial in manufacturing many valuable products such as medicines and agrochemicals. However, conventional methods for carrying out these reactions come with major challenges. They often require harsh conditions like high temperatures and environmentally harmful solvents. Established methods of performing SNAr chemistry often produce compounds as isomeric – two or more compounds that have the same chemical formula but different arrangements of the atoms – mixtures, necessitating the use of expensive and time-consuming purification steps. To overcome these hurdles, a team of researchers, led by Professor Anthony Green and Professor Igor Larrosa, have used directed evolution to develop a new enzyme capable of catalysing SNAr processes. This new enzyme, named SNAr1.3, performs a range of SNAr reactions with high efficiency and selectivity under mild reaction conditions. Unlike traditional chemical methods, this enzyme operates in water-based solutions at moderate temperatures, reducing the environmental impact and energy required.How It WorksAs there is no known natural enzyme that could catalyse SNAr reactions, the team initially discovered that an enzyme previously developed in their laboratory for a different chemical transformation could also perform SNAr chemistry, albeit with modest efficiency and selectivity. By using automated directed evolution, the researchers were able to further engineer this enzyme to have the desired characteristics. The team evaluated over 4,000 clones before identifying an enzyme SNAr1.3 that contains six mutations and is 160-fold more active than the parent enzyme. This enzyme efficiently promotes a wide variety of SNAr processes and can generate target products in a single mirror-image form, which is crucial for applications in the pharmaceutical sector.The Benefits of SNAr1.3SNAr1.3 has a number of features that make it an attractive option for chemical production:<strong>Efficiency:</strong> the enzyme can perform over 4,000 reaction cycles without losing effectiveness, making it highly productive.<strong>Precision:</strong> it creates molecules in a single mirror-image form, which is critical for the safety and effectiveness of medicines.<strong>Versatility:</strong> SNAr1.3 works with a wide range of chemical building blocks, enabling the creation of complex structures like quaternary carbon centres—a common feature in advanced drugs.<strong>Sustainability:</strong> operating under mild, water-based conditions, the enzyme reduces the need for harmful chemicals and energy-intensive processes, making it an environmentally friendly alternative.The team’s work also sheds light on the enzyme’s inner workings. Using advanced analytic techniques, they uncovered how SNAr1.3’s unique structure allows it to bind and position chemicals precisely, enabling its exceptional performance. These insights provide a blueprint for designing even more powerful enzymes in the future.A Greener Future for IndustryThe development of SNAr1.3 highlights the potential of biocatalysis and provides a template for future development. As the world moves towards net zero, and industry is looking for ways to improve efficiency and reduce their environmental impact, biotechnology could be the answer to these pressing challenges.“This is a landmark achievement in biocatalysis,” said Igor Larrosa, Professor and Chair in Organic Chemistry at The University of Manchester. “It demonstrates how we can harness and even improve on nature’s tools to address some of the toughest challenges in modern chemistry.”What’s Next?While SNAr1.3 is already showing immense promise, the researchers believe this is just the beginning. With further refinement, the enzyme could be adapted for even more complex reactions, making it a valuable tool in drug development, agricultural chemicals, and materials science.“The possibilities are just starting to emerge,” said Anthony. “By combining modern protein design with high-throughput testing, we’re optimistic about creating a new generation of enzymes that can revolutionise SNAr chemistry.”This groundbreaking research offers a glimpse into a future where manufacturing essential products is cleaner, cheaper, and more efficient. For industries looking to reduce their environmental impact while maintaining high standards of quality, SNAr1.3 represents a promising solution.</p> </div> </a> </div> <div class="slide"> <a href="https://www.manchester.ac.uk/about/news/leading-scientists-call-for-global-conversation-about-mirror-bacteria/"> <span class="image-container"> <img class="lazynewsx lazy2" src="data:image/gif;base64,R0lGODlhAQABAIAAAPT09AAAACH5BAAAAAAALAAAAAABAAEAAAICRAEAOw==" width="360" height="215" data-original="https://content.presspage.com/uploads/1369/2b7986cb-6cc6-4f86-8774-bec3b3afac4c/500_profpatrickcai.jpg?10000" data-src="https://content.presspage.com/uploads/1369/2b7986cb-6cc6-4f86-8774-bec3b3afac4c/500_profpatrickcai.jpg?10000" alt="" /> <noscript><img src="https://content.presspage.com/uploads/1369/2b7986cb-6cc6-4f86-8774-bec3b3afac4c/500_profpatrickcai.jpg?10000" width="360" height="215" alt="" /></noscript> </span> <div class="carouselContent"> <h3 class="largeTitle">Leading scientists call 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