Search results for: NF-魏B

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NF-魏B</title> <meta name="description" content="Search results for: NF-魏B"> <meta name="keywords" content="NF-魏B"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="NF-魏B"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: NF-魏B</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Risk Factors and Biomarkers for the Recurrence of Ovarian Endometrioma: About the Immunoreactivity of Progesterone Receptor Isoform B and Nuclear Factor Kappa B.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ae%20Ra%20Han">Ae Ra Han</a>, <a href="https://publications.waset.org/abstracts/search?q=Taek%20Hoo%20Lee"> Taek Hoo Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Sun%20Zoo%20Kim"> Sun Zoo Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Hwa%20Young%20%20Lee"> Hwa Young Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Ovarian endometrioma is one of the important causes of poor ovarian reserve and up to half of them have recurred. However, the treatment for recurrence prevention has limited efficiency and repeated surgical management makes worsen the ovarian reserve. To find better management for recurrence prevention, we investigated risk factors and biomarkers for the recurrence of ovarian endometrioma. Methods: The medical records of women with the history of surgical dissection for ovarian endometrioma were collected. After exclusion of the cases with concurrent hysterectomy, been menopaused during follow-up, incomplete medical record, and loss of follow-up, a total of 134 women were enrolled. Immunohistochemical staining for progesterone receptor isoform B (PR-B) and nuclear factor kappa B (NF魏B) was done with the fixed tissue blocks of their endometriomas which were collected at the time of surgery. Results: Severity of dysmenorrhea and co-existence of adenomyosis had significant correlation with recurrence of endometrioma. Increased PR-B (P = .041) and decreased NF魏B (P = .036) immunoreactivity were found in recurrent group. Serum CA-125 level at the time of recurrence was higher than the highest level of CA-125 during follow-up in unrecurred group (55.6 vs. 21.3 U/mL, P = .014). Conclusion: We found that the severity of dysmenorrhea and coexistence of adenomyosis are risk factors for recurrence of ovarian endometrioma, and serial follow-up of CA-125 is effective to detect and prevent the recurrence. However, to determine the possibility of immunoreactivity of PR-B and NF魏B as biomarkers for ovarian endometrioma, further studies of various races and large numbers with prospective design are needed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=endometriosis" title="endometriosis">endometriosis</a>, <a href="https://publications.waset.org/abstracts/search?q=recurrence" title=" recurrence"> recurrence</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarker" title=" biomarker"> biomarker</a>, <a href="https://publications.waset.org/abstracts/search?q=risk%20factor" title=" risk factor"> risk factor</a> </p> <a href="https://publications.waset.org/abstracts/50727/risk-factors-and-biomarkers-for-the-recurrence-of-ovarian-endometrioma-about-the-immunoreactivity-of-progesterone-receptor-isoform-b-and-nuclear-factor-kappa-b" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50727.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">553</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Bioactive Rare Acetogenins from the Red Alga Laurencia obtusa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20A.%20Ghandourah">Mohamed A. Ghandourah</a>, <a href="https://publications.waset.org/abstracts/search?q=Walied%20M.%20Alarif"> Walied M. Alarif</a>, <a href="https://publications.waset.org/abstracts/search?q=Nahed%20O.%20Bawakid"> Nahed O. Bawakid</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Halogenated cyclic enynes and terpenoids are commonly identified among secondary metabolites of the genus Laurencia. Laurencian acetogenins are entirly C15 non-terpenoid haloethers with different carbocyclic nuclei; a specimen of the Red Sea red alga L. obtusa was investigated for its acetogenin content. The dichloromethane extract of the air-dried red algal material was fractionated on aluminum oxide column preparative thin-layer chromatography. Three new rare C12 acetogenin derivatives (1-3) were isolated from the organic extract obtained from Laurencia obtusa, collected from the territorial Red Sea water of Saudi Arabia. The structures of the isolated metabolites were established by means of spectroscopical data analyses. Examining the isolated compounds in activated human peripheral blood mononuclear cells (PBMC) revealed potent Anti-inflammatory activity as evidenced by inhibition of NF魏B and release of other inflammatory mediators like TNF-伪, IL-1尾 and IL-6. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Red%20Sea" title="Red Sea">Red Sea</a>, <a href="https://publications.waset.org/abstracts/search?q=red%20algae" title=" red algae"> red algae</a>, <a href="https://publications.waset.org/abstracts/search?q=fatty%20acids" title=" fatty acids"> fatty acids</a>, <a href="https://publications.waset.org/abstracts/search?q=spectroscopy" title=" spectroscopy"> spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-inflammatory" title=" anti-inflammatory"> anti-inflammatory</a> </p> <a href="https://publications.waset.org/abstracts/85016/bioactive-rare-acetogenins-from-the-red-alga-laurencia-obtusa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85016.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">149</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Let-7 Mirnas Regulate Inflammatory Cytokine Production in Bovine Endometrial Cells after Lipopolysaccharide Challenge by Targeting TNF伪</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Ibrahim">S. Ibrahim</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Salilew-Wondim"> D. Salilew-Wondim</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Hoelker"> M. Hoelker</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Looft"> C. Looft</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Tholen"> E. Tholen</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Grosse-Brinkhaus"> C. Grosse-Brinkhaus</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20Schellander"> K. Schellander</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Neuhoff"> C. Neuhoff</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Tesfaye"> D. Tesfaye</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bovine endometrial cells appear to have a key role in innate immune defense of the female genital tract. A better understanding of molecular changes in microRNAs (miRNAs) and their target genes expression may identify reliable prognostic indicators for cows that will resolve inflammation and resume cyclicity. In the current study, we hypothesized that let-7 miRNAs family has a primary role in the innate immune defence of the endometrium tissue against bacterial infection, which is partly achieved via regulating mRNA stability of pro-inflammatory cytokines at the post-transcriptional level. Therefore, we conducted two experiments. In the first experiment, primary bovine endometrial cells were challenged with clinical (3.0 渭g/ml) and sub-clinical (0.5 渭g/ml) doses of lipopolysaccharide (LPS) for 24h. In the 2nd experiment, we have investigated the potential role of let-7 miRNAs (let-7a and let-7f) using gain and loss of function approaches. Additionally, tumor necrosis factor alpha (TNF伪), transforming growth factor beta 1 induced transcript 1 (TGFB1I1) and serum deprivation response (SDPR) genes were validated using reporter assay. Here we addressed for the first time that let-7 miRNAs have a precise role in bovine endometrium, where LPS dysregulated let-7 miRNAs family expression was associated with an increased pro-inflammatory cytokine level by directly/indirectly targeting the TNF伪, interleukin 6 (IL6), nuclear factor kappa-light-chain enhancer of activated B cells (NF魏B), TGF尾1I1 and SDPR genes. To our knowledge, this is the first study showing that TNF伪, TGF尾1I1 and SDPR were identified and validated as novel let-7 miRNAs targets and could have a distinct role in inflammatory immune response of LPS challenged bovine endometrial cells. Our data represent a new finding by which uterine homeostasis is maintained through functional regulation of let-7a by down-regulation of pro-inflammatory cytokines expression (TNF伪 and IL6) at the mRNA and protein levels. These findings suggest that LPS serves as a negative regulator of let-7 miRNAs expression and provides a mechanism for the persistent pro-inflammatory phenotype, which is a hallmark of bovine subclinical endometritis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bovine%20endometrial%20cells" title="bovine endometrial cells">bovine endometrial cells</a>, <a href="https://publications.waset.org/abstracts/search?q=let-7" title=" let-7"> let-7</a>, <a href="https://publications.waset.org/abstracts/search?q=lipopolysaccharide" title=" lipopolysaccharide"> lipopolysaccharide</a>, <a href="https://publications.waset.org/abstracts/search?q=pro-inflammatory%20cytokines" title=" pro-inflammatory cytokines"> pro-inflammatory cytokines</a> </p> <a href="https://publications.waset.org/abstracts/38494/let-7-mirnas-regulate-inflammatory-cytokine-production-in-bovine-endometrial-cells-after-lipopolysaccharide-challenge-by-targeting-tnfa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38494.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">380</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div 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Search results for: NF-魏B