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ENZYME - 2.4.2.43 lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
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property="schema:alternateName">2.4.2.43</span></h1><div class="main-elmt" style="justify-self:center;"> <table class="type-1"> <tr><th colspan="2">Accepted Name</th></tr> <tr><td colspan="2"><strong property="schema:name">lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase </strong></td></tr> <tr><th colspan="2">Alternative Name(s)</th></tr> <tr><td colspan="2"><strong property="schema:alternateName">4-amino-4-deoxy-L-arabinose lipid A transferase</strong></td></tr> <tr><td colspan="2"><strong property="schema:alternateName">lipid A 4-amino-4-deoxy-L-arabinosyltransferase</strong></td></tr> <tr><td colspan="2"><strong property="schema:alternateName">polymyxin resistance protein PmrK</strong></td></tr> <tr><td colspan="2"><strong property="schema:alternateName">undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase</strong></td></tr> <tr><td colspan="2"><strong property="schema:alternateName">undecaprenyl phosphate-alpha-L-Ara4N transferase</strong></td></tr> <tr><th colspan="2">Reaction catalysed</th></tr> <tr><td colspan="2">4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate<span class="color_d2"> + </span>lipid IVA<span class="color_d2"> = </span>lipid IIA<span class="color_d2"> + </span>di-trans,octa-cis-undecaprenyl phosphate</td></tr> <tr><th colspan="2">Comment(s)</th></tr> <tr><td colspan="2"><ul class="cc"><li>Integral membrane protein present in the inner membrane of certain Gram negative endobacteria. </li><li>In strains that do not produce 3-deoxy-D-manno-octulosonic acid (Kdo), the enzyme adds a single arabinose unit to the 1-phosphate moiety of the tetra-acylated lipid A precursor, lipid IVA. </li><li>In the presence of a Kdo disaccharide, the enzyme primarily adds an arabinose unit to the 4-phosphate of lipid A molecules. </li><li>The Salmonella typhimurium enzyme can add arabinose units to both positions. </li><li>Formerly EC 2.4.2.n1. </li></ul></td></tr> <tr><th colspan="2">Cross-references</th></tr> <tr><td>BRENDA</td><td><a href="http://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.43">2.4.2.43</a></td></tr> <tr><td>EC2PDB</td><td><a href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=2.4.2.43">2.4.2.43</a></td></tr> <tr><td>ExplorEnz</td><td><a href="http://www.enzyme-database.org/query.php?ec=2.4.2.43">2.4.2.43</a></td></tr> <tr><td>KEGG Ligand Database for Enzyme Nomenclature</td><td><a href="http://www.genome.ad.jp/dbget-bin/www_bget?ec:2.4.2.43">2.4.2.43</a></td></tr> <tr><td>IUBMB Enzyme Nomenclature</td><td><a href="https://www.qmul.ac.uk/sbcs/iubmb/enzyme/EC2/4/2/43.html">2.4.2.43</a></td></tr> <tr><td>MEDLINE</td><td><a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=PureSearch&db=PubMed&details_term=2.4.2.43[EC/RN%20Number]">Find literature relating to 2.4.2.43</a></td></tr> <tr><td>MetaCyc</td><td><a href="https://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-2.4.2.43">2.4.2.43</a></td></tr> <tr><td>Rhea expert-curated reactions</td><td><a href="https://www.rhea-db.org/rhea?query=ec%3A2.4.2.43">2.4.2.43</a></td></tr> <tr><td>UniProtKB/Swiss-Prot</td><td><table> <tr><td><a href="https://www.uniprot.org/uniprot/B4EUL1">B4EUL1</a>, ARNT1_PROMH</td><td><a href="https://www.uniprot.org/uniprot/Q4KC80">Q4KC80</a>, ARNT1_PSEF5</td><td><a href="https://www.uniprot.org/uniprot/Q3KCC9">Q3KCC9</a>, ARNT1_PSEPF</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q2NWA9">Q2NWA9</a>, ARNT1_SODGM</td><td><a href="https://www.uniprot.org/uniprot/B4ETL9">B4ETL9</a>, ARNT2_PROMH</td><td><a href="https://www.uniprot.org/uniprot/Q4K884">Q4K884</a>, ARNT2_PSEF5</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q3KCB9">Q3KCB9</a>, ARNT2_PSEPF</td><td><a href="https://www.uniprot.org/uniprot/Q2NRV9">Q2NRV9</a>, ARNT2_SODGM</td><td><a href="https://www.uniprot.org/uniprot/A0KGY4">A0KGY4</a>, ARNT_AERHH</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/A4SQX1">A4SQX1</a>, ARNT_AERS4</td><td><a href="https://www.uniprot.org/uniprot/A7ZP75">A7ZP75</a>, ARNT_ECO24</td><td><a href="https://www.uniprot.org/uniprot/B7UFR9">B7UFR9</a>, ARNT_ECO27</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B7MG24">B7MG24</a>, ARNT_ECO45</td><td><a href="https://www.uniprot.org/uniprot/B7LAS2">B7LAS2</a>, ARNT_ECO55</td><td><a href="https://www.uniprot.org/uniprot/Q8XDZ1">Q8XDZ1</a>, ARNT_ECO57</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B5YXQ0">B5YXQ0</a>, ARNT_ECO5E</td><td><a href="https://www.uniprot.org/uniprot/B7NNT6">B7NNT6</a>, ARNT_ECO7I</td><td><a href="https://www.uniprot.org/uniprot/B7MXT9">B7MXT9</a>, ARNT_ECO81</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B7M5T9">B7M5T9</a>, ARNT_ECO8A</td><td><a href="https://www.uniprot.org/uniprot/B1X8X0">B1X8X0</a>, ARNT_ECODH</td><td><a href="https://www.uniprot.org/uniprot/A8A2C4">A8A2C4</a>, ARNT_ECOHS</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/A1ADA9">A1ADA9</a>, ARNT_ECOK1</td><td><a href="https://www.uniprot.org/uniprot/Q0TFI5">Q0TFI5</a>, ARNT_ECOL5</td><td><a href="https://www.uniprot.org/uniprot/Q8FFL9">Q8FFL9</a>, ARNT_ECOL6</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B1IXT0">B1IXT0</a>, ARNT_ECOLC</td><td><a href="https://www.uniprot.org/uniprot/P76473">P76473</a>, ARNT_ECOLI</td><td><a href="https://www.uniprot.org/uniprot/B7N5M2">B7N5M2</a>, ARNT_ECOLU</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B6I7K0">B6I7K0</a>, ARNT_ECOSE</td><td><a href="https://www.uniprot.org/uniprot/B1LLL1">B1LLL1</a>, ARNT_ECOSM</td><td><a href="https://www.uniprot.org/uniprot/Q1R9F8">Q1R9F8</a>, ARNT_ECOUT</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/C5BDQ8">C5BDQ8</a>, ARNT_EDWI9</td><td><a href="https://www.uniprot.org/uniprot/A4WAM1">A4WAM1</a>, ARNT_ENT38</td><td><a href="https://www.uniprot.org/uniprot/B2VBI7">B2VBI7</a>, ARNT_ERWT9</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B7LM74">B7LM74</a>, ARNT_ESCF3</td><td><a href="https://www.uniprot.org/uniprot/B5XTL1">B5XTL1</a>, ARNT_KLEP3</td><td><a href="https://www.uniprot.org/uniprot/A6TF96">A6TF96</a>, ARNT_KLEP7</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q6D2F3">Q6D2F3</a>, ARNT_PECAS</td><td><a href="https://www.uniprot.org/uniprot/C6DAW3">C6DAW3</a>, ARNT_PECCP</td><td><a href="https://www.uniprot.org/uniprot/Q7N3Q9">Q7N3Q9</a>, ARNT_PHOLL</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q48HY9">Q48HY9</a>, ARNT_PSE14</td><td><a href="https://www.uniprot.org/uniprot/A6V1N8">A6V1N8</a>, ARNT_PSEA7</td><td><a href="https://www.uniprot.org/uniprot/B7VBN0">B7VBN0</a>, ARNT_PSEA8</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q02R27">Q02R27</a>, ARNT_PSEAB</td><td><a href="https://www.uniprot.org/uniprot/Q9HY61">Q9HY61</a>, ARNT_PSEAE</td><td><a href="https://www.uniprot.org/uniprot/Q4ZSZ0">Q4ZSZ0</a>, ARNT_PSEU2</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B5EZI0">B5EZI0</a>, ARNT_SALA4</td><td><a href="https://www.uniprot.org/uniprot/A9MJC5">A9MJC5</a>, ARNT_SALAR</td><td><a href="https://www.uniprot.org/uniprot/Q57M54">Q57M54</a>, ARNT_SALCH</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B5FNU1">B5FNU1</a>, ARNT_SALDC</td><td><a href="https://www.uniprot.org/uniprot/B5R274">B5R274</a>, ARNT_SALEP</td><td><a href="https://www.uniprot.org/uniprot/B5RCC6">B5RCC6</a>, ARNT_SALG2</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B4TBG8">B4TBG8</a>, ARNT_SALHS</td><td><a href="https://www.uniprot.org/uniprot/B4SYX3">B4SYX3</a>, ARNT_SALNS</td><td><a href="https://www.uniprot.org/uniprot/Q5PNA8">Q5PNA8</a>, ARNT_SALPA</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/A9N5B0">A9N5B0</a>, ARNT_SALPB</td><td><a href="https://www.uniprot.org/uniprot/C0Q067">C0Q067</a>, ARNT_SALPC</td><td><a href="https://www.uniprot.org/uniprot/B5BCP4">B5BCP4</a>, ARNT_SALPK</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B4TPI4">B4TPI4</a>, ARNT_SALSV</td><td><a href="https://www.uniprot.org/uniprot/Q8Z538">Q8Z538</a>, ARNT_SALTI</td><td><a href="https://www.uniprot.org/uniprot/O52327">O52327</a>, ARNT_SALTY</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/A8GDR9">A8GDR9</a>, ARNT_SERP5</td><td><a href="https://www.uniprot.org/uniprot/A8FRR0">A8FRR0</a>, ARNT_SHESH</td><td><a href="https://www.uniprot.org/uniprot/B2TW40">B2TW40</a>, ARNT_SHIB3</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q31YK0">Q31YK0</a>, ARNT_SHIBS</td><td><a href="https://www.uniprot.org/uniprot/Q32DT1">Q32DT1</a>, ARNT_SHIDS</td><td><a href="https://www.uniprot.org/uniprot/Q0T2M6">Q0T2M6</a>, ARNT_SHIF8</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q83KB6">Q83KB6</a>, ARNT_SHIFL</td><td><a href="https://www.uniprot.org/uniprot/Q3YZU9">Q3YZU9</a>, ARNT_SHISS</td><td><a href="https://www.uniprot.org/uniprot/Q8D339">Q8D339</a>, ARNT_WIGBR</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/A1JPM4">A1JPM4</a>, ARNT_YERE8</td><td><a href="https://www.uniprot.org/uniprot/A7FHH6">A7FHH6</a>, ARNT_YERP3</td><td><a href="https://www.uniprot.org/uniprot/Q1C744">Q1C744</a>, ARNT_YERPA</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B2K5L1">B2K5L1</a>, ARNT_YERPB</td><td><a href="https://www.uniprot.org/uniprot/Q8ZDX9">Q8ZDX9</a>, ARNT_YERPE</td><td><a href="https://www.uniprot.org/uniprot/A9R091">A9R091</a>, ARNT_YERPG</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/Q1CIH9">Q1CIH9</a>, ARNT_YERPN</td><td><a href="https://www.uniprot.org/uniprot/A4TIM6">A4TIM6</a>, ARNT_YERPP</td><td><a href="https://www.uniprot.org/uniprot/Q66A06">Q66A06</a>, ARNT_YERPS</td></tr> <tr><td><a href="https://www.uniprot.org/uniprot/B1JJ32">B1JJ32</a>, ARNT_YERPY</td></table> </td></tr> </table> <br><a property="schema:sameAs" href="/cgi-bin/enzyme/get-enzyme-entry?2.4.2.43">View entry in original ENZYME format</a> <br><a property="schema:sameAs" href="/EC/2.4.2.43.txt">View entry in raw text format (no links)</a><br> <div property="schema:about" typeof="schema:DataSet"><a property="schema:url" href="https://www.uniprot.org/uniprotkb?query=(ec:2.4.2.43)%20AND%20(reviewed:true)">All UniProtKB/Swiss-Prot entries referenced in this entry</a>, with possibility to download in different formats, align etc. </div> All <a href="/EC/2.4.2.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.4.2.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.4.2.-<br> </span><span property="itemListElement" typeof="ListItem">All <a href="/EC/2.4.-.-">ENZYME</a> / <a href="https://www.uniprot.org/uniprotkb?query=(ec:2.4.-.-)%20AND%20(reviewed:true)">UniProtKB/Swiss-Prot</a> entries corresponding to 2.4.-.-<br> All <a href="/EC/2.-.-.-">ENZYME</a> / <a 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