Cracking the Code of Life: An Interview with Stef van Grieken, CEO of Cradle, on AI-Driven Protein Engineering

<!DOCTYPE html> <html lang="en"> <head> <meta charset="UTF-8"> <title> Cracking the Code of Life: An Interview with Stef van Grieken, CEO of Cradle, on AI-Driven Protein Engineering </title> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="canonical" href="https://www.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/" />  <script async src="https://www.googletagmanager.com/gtag/js?id=G-YK7FCK71TD"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-YK7FCK71TD'); </script> <meta name="description" content="" /> <meta name="keywords" content="" />  <meta name="twitter:card" content="summary_large_image"> <meta name="twitter:title" content="Cracking the Code of Life: An Interview with Stef van Grieken, CEO of Cradle, on AI-Driven Protein Engineering"> <meta name="twitter:description" content=""> <meta name="twitter:image" content="https://www.biopharmatrend.com/files/blog/social/bpt_interviews_stef_van_grieken_soc.jpg">  <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/" /> <meta property="og:title" content="Cracking the Code of Life: An Interview with Stef van Grieken, CEO of Cradle, on AI-Driven Protein Engineering" /> <meta property="og:description" content="" /> <meta property="article:published_time" content="2024-04-26T23:25:39+00:00"> <meta property="article:modified_time" content="2024-04-26T23:25:39+00:00"> <meta name="author" content="Andrii Buvailo, PhD"> <meta property="og:image" content="https://www.biopharmatrend.com/files/blog/social/bpt_interviews_stef_van_grieken_soc.jpg"> <script type="application/ld+json">{ "@context": "https://schema.org", "@type": "Article", "headline": "Cracking the Code of Life: An Interview with Stef van Grieken, CEO of Cradle, on AI-Driven Protein Engineering", "datePublished": "2024-04-26T23:25:39+00:00", "dateModified": "2024-04-26T23:25:39+00:00", "description": "The integration of artificial intelligence (AI) in biotech is not just enhancing the efficiency of processes but is also enabling the discovery of novel biological insights that were once beyond reach. As the industry seeks to meet the increasing demand for protein-based products across various sectors, including pharmaceuticals, agriculture, and food, the role of AI becomes increasingly important.\nIn this context, our conversation with\nStef van Grieken\n, Co-founder and CEO of\nCradle\n, provides a glimpse into how cutting-edge AI technologies and strategic collaborations are accelerating the pace of innovation in protein engineering.\nStef shares the intriguing story behind Cradle's partnership with Ginkgo Bioworks, highlighting their shared vision and the synergistic combination of Cradle\u2019s generative AI software and Ginkgo's robust experimental capabilities.\nThis interview delves into the growing impact\u00a0of AI on biotechnological processes,\u00a0the challenges currently faced by R&D teams, and how Cradle's unique approach is contributing to the protein engineering landscape.", "image": 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src="/static/img/linkedin_icon_50x50.71dcf83d1029.png" class="author-linkein-icon" /> </a>  </span>    <span style="white-space: nowrap;"> <span class="glyphicon glyphicon-folder-open"></span>   Interview </span> <div class="tooltip-text"> <div class="tooltip-close" onclick="this.parentElement.parentElement.classList.toggle('tooltip-show');"></div> <p><b>Disclaimer</b>: All opinions expressed by Contributors are their own and do not represent those of their employers, or BiopharmaTrend.com. <br> Contributors are fully responsible for assuring they own any required copyright for any content they submit to BiopharmaTrend.com. This website and its owners shall not be liable for neither information and content submitted for publication by Contributors, nor its accuracy.</p> </div> </div> <div> <span class="glyphicon glyphicon-calendar" title="Published on"></span> <time datetime="2024-04-26">April 26, 2024</time>    </em> </div> <div class="tags"> <b>Topics: </b> <a href="/topic/ai-digital/">AI & Digital</a>    </div> <div> <strong>Share: </strong>   <a target="_blank" rel="nofollow" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in LinkedIn" src="/static/img/soc-in.7bc286fd757e.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.reddit.com/submit?url=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in Reddit" src="/static/img/soc-reddit.342e87a07115.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in X" src="/static/img/soc-x.3c80e8291cba.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://news.ycombinator.com/submitlink?u=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in Hacker News" src="/static/img/soc-y.587f16a5f3f3.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/&display=page"> <img alt="Share in Facebook" src="/static/img/soc-fb.3031a5a810f0.png" width="28" height="28" /></a>  <a target="_blank" rel="nofollow" href="mailto:?subject=Biopharmatrend.com&body=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Send by email" src="/static/img/soc-mail.41ce3608f438.png" width="28" height="28"></a> </div> </footer> <section> <p>The integration of artificial intelligence (AI) in biotech is not just enhancing the efficiency of processes but is also enabling the discovery of novel biological insights that were once beyond reach. As the industry seeks to meet the increasing demand for protein-based products across various sectors, including pharmaceuticals, agriculture, and food, the role of AI becomes increasingly important.</p> <p>In this context, our conversation with <a href="https://www.linkedin.com/in/stefvangrieken/">Stef van Grieken</a>, Co-founder and CEO of <a href="https://www.biopharmatrend.com/m/company/cradle/">Cradle</a>, provides a glimpse into how cutting-edge AI technologies and strategic collaborations are accelerating the pace of innovation in protein engineering.</p> <p>Stef shares the intriguing story behind Cradle's partnership with Ginkgo Bioworks, highlighting their shared vision and the synergistic combination of Cradle’s generative AI software and Ginkgo's robust experimental capabilities.</p> <p>This interview delves into the growing impact of AI on biotechnological processes, the challenges currently faced by R&D teams, and how Cradle's unique approach is contributing to the protein engineering landscape. </p> <div style="overflow: hidden;"><p>聽</p><h4><u>Andrii</u>: Stef, could you share the story behind the partnership between Cradle and Ginkgo Bioworks? What were the key factors or shared visions that led to this collaboration?</h4><p><img alt="" class="post-image" src="/files/uploads/2024/04/15/bpt_interviews_stef_van_grieken_img1.webp"/><u><strong>Stef: </strong></u>There is a significantly rising demand for more protein-based products to come to market across pharma, chemicals, food and agriculture. Cradle was invited to be one of the founding members of the Ginkgo Technology Network to provide software that allows any R&D team to engineer better proteins using generative AI across enzymes, antibodies, cytokines, vaccines and peptides.聽</p><p>We are excited to work with Ginkgo, who has some of the best large-scale experimental capabilities that cover a broad range of applications. This partnership is geared towards customers who want to leverage Cradle鈥檚 generative ML for protein engineering, but who do not have the capacity to quickly validate designed proteins in a high-throughput wet lab. Taking enzyme engineering as an example, Cradle & Ginkgo can provide on-demand multi-property optimization of enzyme activity, thermal stability, pH tolerance, solvent stability, secretion, and expression in common hosts.聽</p><p>What we believe is unique about this partnership is that teams of scientists can now work together on optimising a protein from the comfort of their browser. With high throughput & high quality experimental data made available for further ML optimization in just 6 weeks, R&D teams can bring protein-based products to market faster without ever having to step into a lab. Both Cradle and Ginkgo have a mission to enable any team in the industry to bring bio-based products to the market in record time and we feel our capabilities are very complementary, which is why we decided to partner.</p><p>聽</p></div> <div class="access-premium text-center"> <h3>Continue reading</h3> <p><big>This content available exclusively for BPT Mebmers</big></p> <div><a href="/membership/?success_page=/post/784-interview-with-stef-van-grieken-from-cradle/&utm_source=website&utm_medium=post&utm_campaign=post_784" class="btn btn-bpt-white"> BPT Membership </a></div> <div><button type="button" onclick="document.getElementById('login-popup').classList.toggle('hidden')" class="btn btn-link" style="color:white; vertical-align: middle;"> Sign in </button></div> </div> <p> <b>Topics: </b> <a href="/topic/ai-digital/">AI & Digital</a>    </p> </section> </article> <div style="margin: 1em 0 2em; padding: 0.5em 0;"> <strong>Share: </strong>   <a target="_blank" rel="nofollow" href="https://www.linkedin.com/sharing/share-offsite/?url=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in LinkedIn" src="/static/img/soc-in.7bc286fd757e.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.reddit.com/submit?url=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in Reddit" src="/static/img/soc-reddit.342e87a07115.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in X" src="/static/img/soc-x.3c80e8291cba.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://news.ycombinator.com/submitlink?u=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Share in Hacker News" src="/static/img/soc-y.587f16a5f3f3.png" width="28" height="28"></a>  <a target="_blank" rel="nofollow" href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/&display=page"> <img alt="Share in Facebook" src="/static/img/soc-fb.3031a5a810f0.png" width="28" height="28" /></a>  <a target="_blank" rel="nofollow" href="mailto:?subject=Biopharmatrend.com&body=https%3A%2F%2Fwww.biopharmatrend.com/post/784-interview-with-stef-van-grieken-from-cradle/"> <img alt="Send by email" src="/static/img/soc-mail.41ce3608f438.png" width="28" height="28"></a> </div> <div class="subscribe-block"> <div class="subscribe-inner"> <h3 style="line-height:1.5; 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Cracking the Code of Life: An Interview with Stef van Grieken, CEO of Cradle, on AI-Driven Protein Engineering