Recombinant Human Latent TGF-beta 1 Protein 299-LT-005: R&D Systems

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class="ds_title_table"> <h1 class="ds_title">Recombinant Human Latent TGF-beta 1 Protein </h1> <div class="dsSprite_rnd ds_brand_logo ds_rnd_logo"></div> </div> <div class="product_meta"> <span class="category_number">Catalog #: 299-LT</span> <br/> <span class="citations"> <a href="#product-citations" id="citation_count" class="jump_to" data-tab="3" data-tabname="product-citations"> 19 Citations </a> </span> <span class="reviews review_stars_5"> <a href="#product-reviews" id="product_reviews" class="jump_to" data-tab="6" data-tabname="product-reviews"> 3 Reviews </a> </span> <a href="/reviews/299-LT" rel="nofollow"><span class="submit_review"><button class="btn btn-quaternary">Submit a Review</button></span></a> <span class="datasheet_link"> <a href="#product-datasheets">Datasheet / COA / SDS</a> </span> </div> <div class="product_info">Soon to be discontinued. New Cat# will be 299-LTB</div>  <div class="product_wrapper row"> <div class="product_ordering_wrapper col-xs-12 col-md-8 col-md-push-4"> <div class="product_ordering"> <form action="/products/recombinant-human-latent-tgf-beta-1-protein_299-lt" method="post" id="atc-datasheet-form" accept-charset="UTF-8"><div><div id="atc_datasheet_block">  <div class="atc_datasheet_table_container"> <p class="protein-cf-subtitle">Carrier Free <span class="icon-information-outline2 ml-1" data-toggle="tooltip" data-placement="right" title="No added BSA"></span></p> <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th class="ds_availability_column mobile-hide">Availability</th> <th class="ds_size_price_column">Size / Price</th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="299-LT-005/CF"> <td class="dat_catalog_column">299-LT-005/CF</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-299-lt-0052fcf form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-299-lt-0052fcf" name="catnum-299-LT-005%2FCF" value="" size="5" maxlength="3" /></div></td> </tr> <tr class="et_atc_product" data-sku="299-LT-025/CF"> <td class="dat_catalog_column">299-LT-025/CF</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-299-lt-0252fcf form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-299-lt-0252fcf" name="catnum-299-LT-025%2FCF" value="" size="5" maxlength="3" /></div></td> </tr> </tbody> </table> </div> <div class="atc_datasheet_table_container"> <p class="protein-cf-subtitle">With Carrier <span class="icon-information-outline2 ml-1" data-toggle="tooltip" data-placement="right" title="Formulated with BSA to improve stability"></span></p> <table class="add_to_cart"> <thead> <tr> <th class="ds_catalog">Catalog #</th> <th class="ds_availability_column mobile-hide">Availability</th> <th class="ds_size_price_column">Size / Price</th> <th class="ds_quantity_column">Qty</th> </tr> </thead> <tbody> <tr class="et_atc_product" data-sku="299-LT-005"> <td class="dat_catalog_column">299-LT-005</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-299-lt-005 form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-299-lt-005" name="catnum-299-LT-005" value="" size="5" maxlength="3" /></div></td> </tr> <tr class="et_atc_product" data-sku="299-LT-025"> <td class="dat_catalog_column">299-LT-025</td> <td class="et_atc_results" colspan="2"></td> <td class="ds_quantity ds_quantity_column"><div class="form-item form-item-catnum-299-lt-025 form-type-textfield form-group"><input class="atc_quantity atc_hidden atc_qty form-control form-text" placeholder="0" style="display:none;" type="text" id="edit-catnum-299-lt-025" name="catnum-299-LT-025" value="" size="5" maxlength="3" /></div></td> </tr> </tbody> </table> </div>    <div class="ds_atc_pre_buttons"></div> <div class="ds_atc_buttons"> <a href="/quote/instruments/ella-automated-immunoassay-system" class="btn btn-secondary atc_request_quote_simple_plex_assay" style="display:none" rel="nofollow">Request a Quote</a> <a href="/services/bulk-quote-request?catnum=299-LT&product=Recombinant Human Latent TGF-beta 1 Protein" class="btn btn-secondary atc_hidden bulk_btn" style="display:none;" rel="nofollow" title="Competitive discounts on products purchased in bulk quantities">Bulk Orders</a> <button class="btn btn-primary atc_hidden atc_btn form-submit icon-before" style="display:none;" title="Enter quantities above and click to add to cart" type="submit" id="edit-add-to-cart" name="add_to_cart_btn" value="Add to Cart"><span class="icon glyphicon glyphicon-plus" aria-hidden="true"></span> Add to Cart</button> </div> <div class="ds_atc_post_buttons"></div> </div> <input type="hidden" name="form_build_id" value="form-9BhCrQnj5aqecQ4xhoWgU8a6vgEKZHB_KLcfjaOC6HY" /> <input type="hidden" name="form_id" value="atc_datasheet_form" /> </div></form> </div> </div> <div class="product_image_wrapper col-xs-12 col-md-4 col-md-pull-8"> <div class="product_image"> <span class="product_image_label"> </span> <a class="ds-image overview-images" data-toggle="lightbox" data-gallery="overview-images" onClick="event.preventDefault();" data-title="Recombinant Human Latent TGF-beta 1 Protein Bioactivity" data-footer="Recombinant Human Latent TGF-beta 1 Protein Bioactivity" title="Cat. No. 299-LT - Recombinant Human Latent TGF-beta 1 Protein" href="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2083.jpg"> <img fetchpriority="high" src="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2083.jpg" class="img-fluid" alt="Recombinant Human Latent TGF-beta 1 Protein Bioactivity" title="Recombinant Human Latent TGF-beta 1 Protein Bioactivity"> </a> <div class="search_image_other_count"> <span class="search_more_images">2 Images</span> </div> </div> </div> <div id="extra_images overview-images" class="hidden"> <a class="ds-image" data-toggle="lightbox" data-gallery="overview-images" data-footer="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE" data-title="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE" title="Cat. No. 299-LT - Recombinant Human Latent TGF-beta 1 Protein" onClick="event.preventDefault();" href="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2084.jpg"> <img src="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2084.jpg" class="img-fluid" loading="lazy" alt="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE" title="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE"> </a> </div> </div> <div class="product_info_wrapper"> </div> <div id="view-more-target" class="datasheet_section_element"> <a href="/target/tgf-beta-1?category=Proteins and Enzymes" class="btn btn-secondary">All TGF-beta 1 Proteins and Enzymes</a> </div> </div> <div class="tabbed_content" id="rnd_protein"> <div id="ds_tabs" class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="product-details" id="dsTabs_product-details"> <span>Product Details</span> </div> <div class="tab tab_3" data-tab="3" data-tabname="product-citations" id="dsTabs_product-citations"> <span>Citations (19)</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="faqs" id="dsTabs_faqs"> <span>FAQs</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="product-reviews" id="dsTabs_product-reviews"> <span> Reviews (3) </span> </div> </div> <div class="tab_content tab_1 tab_open" data-tab="1" data-tabname="product-details" id="product-details"> <div class="datasheet_section_element"> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_summary" id="product-anchor-ds_summary">Summary</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_datasheets" id="product-anchor-ds_datasheets">Product Datasheets</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_carrier_free" id="product-anchor-ds_carrier_free">Carrier Free</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_data_examples" id="product-anchor-ds_data_examples">Data Images</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_calculator" id="product-anchor-ds_calculator">Reconstitution Calculator</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_background" id="product-anchor-ds_background">Background</a> <a class="btn btn-quaternary scroll_to anchor-link" href="#ds_related_research_areas" id="product-anchor-ds_related_research_areas">Related Research Areas</a> </div> <div id="ds_summary" class="datasheet_section"> <h2>Recombinant Human Latent TGF-beta 1 Protein Summary</h2> <div class="what-statement-container"> </div> <div class="why-statement-container"> </div> <h4 class="mt-3">Product Specifications</h4> <div class="ds_table summary_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Purity</div> <div class="ds_table_cell summary_table_data">>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Endotoxin Level</div> <div class="ds_table_cell summary_table_data"><0.10 EU per 1 μg of the protein by the LAL method.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Activity</div> <div class="ds_table_cell summary_table_data">Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. <EM>et al</EM>. (1995) Cytokine <STRONG>7</STRONG>:389. The ED<sub>50</sub> for this effect is 10-70 ng/mL before acid activation and 0.15‑0.9 ng/mL after acid activation.</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Source</div> <div class="ds_table_cell summary_table_data">Chinese Hamster Ovary cell line, CHO-derived human TGF-beta 1 protein<br />Leu30-Ser390</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Accession #</div> <div class="ds_table_cell summary_table_data"><a href="http://www.ncbi.nlm.nih.gov/protein/P01137" target="_blank" rel="noreferrer nofollow">P01137</a></div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">N-terminal Sequence<br />Analysis</div> <div class="ds_table_cell summary_table_data">Leu30 (LAP) & Ala279 (Mature)<br></div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">Predicted Molecular Mass</div> <div class="ds_table_cell summary_table_data">28.5 kDa (LAP) & 12.8 kDa (Mature), Monomer</div> </div> <div class="ds_table_row"> <div class="ds_table_cell summary_table_name">SDS-PAGE</div> <div class="ds_table_cell summary_table_data">36-42 kDa & 11 kDa, reducing conditions<br>80-95 kDa & 24 kDa, non-reducing conditions</div> </div> </div> </div> </div> <div id="customer_also_purchased_block" class="loader" data-catalogId="299-LT"></div> <div class="datasheet_section" id="product-datasheets"> <h2 id="ds_datasheets">Product Datasheets</h2> <div class="product_datasheets"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <h2>299-LT (with carrier)</h2> <div class="ds_document"> <a id="cfpdf" href="//resources.rndsystems.com/pdfs/datasheets/299-lt.pdf?v=20241123" class="datasheets-link " target="_blank" rel="noreferrer nofollow">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/recombinant-human-latent-tgf-beta-1-protein_299-lt">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_non_cf datasheets-link non_cf_download_link" target="_blank" rel="noreferrer" data-path="//aero.bio-techne.com/sds/pdf/299-lt?v=20241123">SDS</a> </div> </div> <div class="product_datasheets" style="margin-top: 15px;"> <span class="sds-message hide"> <p class="sds-label">You must select a language.</p> <span class="close_sds_message">x</span> </span> <h2>299-LT/CF (carrier free)</h2> <div class="ds_document"> <a id="cfpdf" href="//resources.rndsystems.com/pdfs/datasheets/299-lt_cf.pdf?v=20241123" class="datasheets-link " target="_blank" rel="noreferrer">Product Datasheet</a> </div> <div class="ds_document"> <div class="ds_pdfData"><a class="datasheets-link" href="https://www.rndsystems.com/cofas/recombinant-human-latent-tgf-beta-1-protein_299-lt">COA</a> </div> </div> <div class="ds_document sds_link"> <a class="sds_cf datasheets-link cf_download_link" target="_blank" rel="noreferrer" data-path="//aero.bio-techne.com/sds/pdf/299-lt/cf?v=20241123">SDS</a> </div> </div> </div> <div id="ds_carrier_free" class="datasheet_section"> <h2>Carrier Free</h2> <div class="highlight">What does CF mean?</div> <p>CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA. </p> <div class="highlight">What formulation is right for me?</div> <p>In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere. </p> <div class="cf_tables row"> <div class="cf_table_1 col-xs-12 col-md-6"> <h4 class="cf_table_name">299-LT</h4> <table class="ds_table_html carrier_free_table"> <tbody> <tr> <td class="cf_key_name">Formulation</td> <td>Supplied as a 0.2 μm filtered solution in PBS and Glycerol with BSA as a carrier protein.</td> </tr> <tr> <td class="cf_key_name">Shipping</td> <td>The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="cf_key_name">Stability & Storage:</td> <td><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles.</b><UL><LI>12 months from date of receipt, -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after opening.</LI><LI>3 months, ≤ -20 °C under sterile conditions after opening.</LI></UL></td> </tr> </tbody> </table> </div> <div class="cf_table_2 col-xs-12 col-md-6"> <h4 class="cf_table_name">299-LT/CF</h4> <table class="ds_table_html carrier_free_table"> <tbody> <tr> <td class="cf_key_name">Formulation</td> <td>Supplied as a 0.2 μm filtered solution in PBS and Glycerol.</td> </tr> <tr> </tr> <tr> <td class="cf_key_name">Shipping</td> <td>The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="cf_key_name">Stability & Storage:</td> <td><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles.</b><UL><LI>12 months from date of receipt, -70 °C as supplied.</LI><LI>1 month, 2 to 8 °C under sterile conditions after opening.</LI><LI>3 months, ≤ -20 °C under sterile conditions after opening.</LI></UL></td> </tr> </tbody> </table> </div> </div> </div> <div id="ds_scientific_data" class="datasheet_section"> <div id="ds_data_examples"> <h2>Scientific Data</h2> <div id="data_examples"> <div class="row data_ex_row"> <a id="ds_image_0" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> Bioactivity </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-0" data-title="Recombinant Human Latent TGF-beta 1 Protein Bioactivity" data-footer="Recombinant Human Latent TGF-beta 1 Protein Bioactivity" title="Cat. No. - Recombinant Human Latent TGF-beta 1 Protein Bioactivity" href="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2083.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2083.jpg" class="img-fluid" alt="Recombinant Human Latent TGF-beta 1 Protein Bioactivity" title="Recombinant Human Latent TGF-beta 1 Protein Bioactivity"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> Recombinant Human Latent TGF-beta beta 1 (Catalog # 299-LT) after acid activation inhibits Recombinant Mouse IL-4 (Catalog # <a class="NoLineLink" href="https://www.rndsystems.com/products/recombinant-mouse-il-4-protein_404-ml">404-ML</a>) induced cell proliferation in the HT-2 mouse T cell line. The ED<sub>50</sub> for this effect is 0.15-0.9 ng/mL after acid activation. </p> </div> </div> <div class="row data_ex_row"> <a id="ds_image_1" class="pageAnchor"></a> <div class="data_ex_image_wrapper col-xs-12 col-sm-5 col-md-4"> <div class="data_ex_image"> <span class="data_ex_image_label"> SDS-PAGE </span> <a class="ds-image overview-images data_ex_image_link" data-toggle="lightbox" data-gallery="overview-images-1" data-title="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE" data-footer="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE" title="Cat. No. - Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE" href="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2084.jpg"> <img loading="lazy" src="https://resources.rndsystems.com/images/datasheets/protein/TGFbeta_1_299LT_2084.jpg" class="img-fluid" alt="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE" title="Recombinant Human Latent TGF-beta 1 Protein SDS-PAGE"> <span class="data_ex_image_larger">View Larger</span> </a> </div> </div> <div class="data_ex_description col-xs-12 col-sm-7 col-md-8"> <p> 1 μg/lane of Recombinant Human Latent TGF‑ beta 1 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silverstaining, showing bands at 11, 36-42 kDa (R) and 24, 80-95 kDa (NR). </p> </div> </div> </div> </div> </div> <div id="ds_calculator" class="datasheet_section"> <div id="btn_calculator_wrapper"><div class="datasheet_calculator_toggle btn btn-secondary" id="btn_reconstitution">Reconstitution Calculator</div></div><div id="datasheet_calculators"><div id="btn_reconstitution_calc" class="datasheet_calculator"><h2>Reconstitution Calculator</h2><div id="reconstitution_calculator" class="calculator"> <form id="recCalc"> <div class="reconstitution_calculator_text" id="reconstitution_calculator_instructions"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> </div> <div class="calc_section"> <label for="reconstitution_calculator_volume" class="calculator_label">Volume (to add to vial)</label> <input id="reconstitution_calculator_volume" name="reconstitution_calculator_volume" type="text" maxlength="16" placeholder="volume" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_volume_unit" class="calculator_input calculator_select"> <option value="ml">ml</option> <option value="ul" selected="selected">ul</option> </select> </span> </div> <span class="calculator_equals calculator_operator">=</span> <div class="calc_section"> <label for="reconstitution_calculator_mass" class="calculator_label">Mass (in vial)</label> <input id="reconstitution_calculator_mass" name="reconstitution_calculator_mass" type="text" maxlength="16" placeholder="mass" class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_mass_unit" class="calculator_input calculator_select"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </span> </div> <span class="calculator_divide calculator_operator">÷</span> <div class="calc_section"> <label for="reconstitution_calculator_concentration" class="calculator_label">Desired Reconstitution Concentration</label> <input id="reconstitution_calculator_concentration" name="reconstitution_calculator_concentration" type="text" maxlength="16" placeholder="conc." class="calculator_input calculator_text"/> <span class="select_wrapper"> <select id="reconstitution_calculator_concentration_unit" class="calculator_input calculator_select"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">ug/ml</option> <option value="ng/ml">ng/ml</option> </select> </span> </div> <div id="reconstitution_foot" class="calc_section"> <input type="submit" value="Calculate" id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-secondary"/> </div> </form> </div> </div></div> </div> <div id="ds_background" class="datasheet_section"> <h2>Background: TGF-beta 1</h2> <p><P>TGF-  beta 1 (transforming growth factor beta 1) and the closely related TGF-beta 2 and -3 are members of the large TGF-beta  superfamily. TGF-  beta proteins are highly pleiotropic cytokines that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1-3). Human TGF-beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (4). A furin-like convertase processes the proprotein within the trans-Golgi to generate an N‑terminal 249 aa latency-associated peptide (LAP) and a C-terminal 112 aa mature TGF-beta 1 (4-6). Disulfide-linked homodimers of LAP and TGF-beta 1 remain non‑covalently associated after secretion, forming the small latent TGF-beta 1 complex (4-8). Purified LAP is also capable of associating with active TGF-beta with high affinity, and can neutralize TGF-beta activity (9). Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (5-7). TGF-beta activation from latency is controlled both spatially and temporally, by multiple pathways that include actions of proteases such as plasmin and MMP9, and/or by thrombospondin 1 or selected integrins (5, 8). The LAP portion of human TGF-beta 1 shares 91%, 92%, 85%, 86% and 88% aa identity with porcine, canine, mouse, rat and equine TGF-beta 1 LAP, respectively, while the mature human TGF-beta 1 portion shares 100% aa identity with procine, canine and bovine TGF-beta 1, and 99% aa identity with mouse, rat and equine TGF-beta 1. Although different isoforms of TGF-beta are naturally associated with their own distinct LAPs, the TGF-beta 1 LAP is capable of complexing with, and inactivating, all other human TGF-beta isoforms and those of most other species (9). Mutations within the LAP are associated with Camurati-Engelmann disease, a rare sclerosing bone dysplasia characterized by inappropriate presence of active TGF-beta 1 (10).</P></p> <div class="ds_table background_table"> <div class="ds_table_body"> <div class="ds_table_row"> <div class="ds_table_cell background_table_name"><a id="reftop"></a>References</div> <div class="ds_table_cell background_table_data"><OL> <LI>Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. <STRONG>267</STRONG>:6982.</LI> <LI>Wahl, S.M. (2006) Immunol. Rev. <STRONG>213</STRONG>:213.</LI> <LI>Chang, H. <EM>et al.</EM> (2002) Endocr. Rev. <STRONG>23</STRONG>:787.</LI> <LI>Derynck, R. <EM>et al</EM>. (1985) Nature <STRONG>316</STRONG>:701.</LI> <LI>Dabovic, B. and D.B. Rifkin (2008) “TGF-beta Bioavailability” in <EM>The TGF-beta Family.</EM> Derynck, R. and K. Miyazono (eds): Cold Spring Harbor Laboratory Press, p. 179.</LI> <LI>Brunner, A.M. <EM>et al.</EM> (1989) J. Biol. Chem. <STRONG>264</STRONG>:13660.</LI> <LI>Miyazono, K. <EM>et al.</EM> (1991) EMBO J. <STRONG>10</STRONG>:1091.</LI> <LI>Oklu, R. and R. Hesketh (2000) Biochem. J. <STRONG>352</STRONG>:601.</LI> <LI>Miller, D.M. <EM>et al.</EM> (1992) Mol. Endocrinol. <STRONG>6</STRONG>:694.</LI> <LI>Janssens, K. <EM>et al.</EM> (2003) J. Biol. Chem. <STRONG>278</STRONG>:7718.</LI></OL></div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Long Name</div> <div class="ds_table_cell background_table_data">Transforming Growth Factor beta 1</div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Entrez Gene IDs</div> <div class="ds_table_cell background_table_data">7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine)</div> </div> <div class="ds_table_row"> <div class="ds_table_cell background_table_name">Alternate Names</div> <div class="ds_table_cell background_table_data">CEDLAP; DPD1; latency-associated peptide; TGF beta; TGF beta1; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1</div> </div> </div> </div> </div> <div id="ds_related_research_areas" class="datasheet_section"> <h2>Related Research Areas</h2> <ul class="ds_details"> <li> <a href="/research-area/airway-inflammation-and-remodeling">Airway Inflammation and Remodeling</a> </li> <li> <a href="/research-area/alpha-granule-soluble-molecules">Alpha Granule Soluble Molecules</a> </li> <li> <a href="/research-area/cancer-biomarkers">Cancer Biomarkers</a> </li> <li> <a href="/research-area/cytokines-and-receptors-in-allergy-and-asthma">Cytokines and Receptors in Allergy and Asthma</a> </li> <li> <a href="/research-area/cytokines-and-receptors-in-angiogenesis">Cytokines and Receptors in Angiogenesis</a> </li> <li> <a href="/research-area/early-mesodermal-lineage-markers">Early Mesodermal Lineage Markers</a> </li> <li> <a href="/research-area/emt-induction">EMT Induction</a> </li> <li> <a href="/research-area/hif-transcription-factors">HIF Transcription Factors</a> </li> <li> <a href="/research-area/inflammatory-mediators">Inflammatory Mediators</a> </li> <li> <a href="/research-area/microglia-activation-markers">Microglia Activation Markers</a> </li> <li> <a href="/research-area/microglia-homeostasis">Microglia Homeostasis</a> </li> <li> <a href="/research-area/myeloid--derived-suppressor-cells--mdsc">Myeloid-derived Suppressor Cells (MDSC)</a> </li> <li> <a href="/research-area/neuroinflammatory-factors">Neuroinflammatory Factors</a> </li> <li> <a href="/research-area/preeclampsia">Preeclampsia</a> </li> <li> <a href="/research-area/regulatory-t-cells--tregs">Regulatory T Cells (Tregs)</a> </li> <li> <a href="/research-area/search-cytokine-and-growth-factor-products">Search Cytokine and Growth Factor Products</a> </li> <li> <a href="/research-area/tgf--beta-family">TGF-beta Family</a> </li> <li> <a href="/research-area/tgf--beta-family-ligands">TGF-beta Family Ligands</a> </li> </ul> </div> </div> <div class="tab_content tab_3" data-tab="3" data-tabname="product-citations" id="citations"> <a id="citations_section"></a> <h2><span class="citations">Citations for Recombinant Human Latent TGF-beta 1 Protein</h2> <div id="citation"> <a id="dsTabCitations"></a> <p> R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. </p> <p> <strong><span id="maxcitations">19</span> Citations: Showing <span id="showfrom">1</span> - <span id="showto">10</span> </strong> <br/><strong>Filter your results:</strong> </p> <div class="row"> <div class="col-sm-12"> <div class="citations_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper filter_select"> <select id="selSpecies" title="Species"> <option value="All">All Species</option> <option class="citation_filterRadio" value="species" data-filter="Human"> Human </option> <option class="citation_filterRadio" value="species" data-filter="Mouse"> Mouse </option> <option class="citation_filterRadio" value="species" data-filter="NA"> N/A </option> <option class="citation_filterRadio" value="species" data-filter="Porcine"> Porcine </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selAntibody" title="Applications"> <option value="All">All Applications</option> <option class="citation_filterRadio" value="application" data-filter="Activation"> Activation </option> <option class="citation_filterRadio" value="application" data-filter="Binding Assay"> Binding Assay </option> <option class="citation_filterRadio" value="application" data-filter="Bioassay"> Bioassay </option> <option class="citation_filterRadio" value="application" data-filter="Cell Culture"> Cell Culture </option> <option class="citation_filterRadio" value="application" data-filter="Surface Plasmon Resonance"> Surface Plasmon Resonance </option> <option class="citation_filterRadio" value="application" data-filter="Western Blot"> Western Blot </option> </select> </div> <div class="select_wrapper filter_select"> <select id="selSampleType" title="Sample Types"> <option value="All">All Sample Types</option> <option class="citation_filterRadio" value="sampletype" data-filter="In Vivo"> In Vivo </option> <option class="citation_filterRadio" value="sampletype" data-filter="NA"> N/A </option> <option class="citation_filterRadio" value="sampletype" data-filter="Protein"> Protein </option> <option class="citation_filterRadio" value="sampletype" data-filter="Recombinant Protein"> Recombinant Protein </option> <option class="citation_filterRadio" value="sampletype" data-filter="Whole Cells"> Whole Cells </option> </select> </div> </div> </div> </div> <div class="row"> <ol id="citations" class="col-xs-12" data-expandall="false" data-max-citations="19" data-max-show="10"> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/37099426"> Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells </a> </span><br/> Authors: T Fukaya, T Uto, S Mitoma, H Takagi, Y Nishikawa, M Tominaga, N Choijookhu, Y Hishikawa, K Sato<br/> Cell Reports, 2023-04-25;42(5):112431.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/36730267"> High glucose promotes regulatory T cell differentiation </a> </span><br/> Authors: E Pitmon, EV Meehan, E Ahmadi, AJ Adler, K Wang<br/> PLoS ONE, 2023-02-02;18(2):e0280916.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="In Vivo"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/35406764"> TGF-beta1 Reduces Neutrophil Adhesion and Prevents Acute Vaso-Occlusive Processes in Sickle Cell Disease Mice </a> </span><br/> Authors: LS Torres, H Chweih, FCZ Fabris, EMF Gotardo, FC Leonardo, STO Saad, FF Costa, N Conran<br/> Cells, 2022-04-02;11(7):.<br/> Species: Mouse<br/> Sample Types: In Vivo<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/32393780"> Immune modulation by complement receptor 3-dependent human monocyte TGF-beta1-transporting vesicles </a> </span><br/> Authors: LD Halder, EAH Jo, MZ Hasan, M Ferreira-G, T Krüger, M Westermann, DI Palme, G Rambach, N Beyersdorf, C Speth, ID Jacobsen, O Kniemeyer, B Jungnickel, PF Zipfel, C Skerka<br/> Nat Commun, 2020-05-11;11(1):2331.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="" data-application="Surface Plasmon Resonance" data-sampletype=""> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/32144206"> Inter-&alpha-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation </a> </span><br/> Authors: DC Briggs, AWW Langford-S, HL Birchenoug, TA Jowitt, CM Kielty, JJ Enghild, C Baldock, CM Milner, AJ Day<br/> J. Biol. Chem., 2020-03-06;0(0):.<br/> Applications: Surface Plasmon Resonance </li> <li class="top-lined" data-species="NA" data-application="Surface Plasmon Resonance" data-sampletype="Protein"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/31988245"> Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1 </a> </span><br/> Authors: TJ Broekelman, NK Bodmer, RP Mecham<br/> J. Biol. Chem., 2020-01-27;0(0):.<br/> Species: N/A<br/> Sample Types: Protein<br/> Applications: Surface Plasmon Resonance </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/30271438"> D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion </a> </span><br/> Authors: L Guo, Y Hou, L Song, S Zhu, F Lin, Y Bai<br/> Stem Cells Int, 2018-09-09;2018(0):7168231.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/28376277"> Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis </a> </span><br/> Authors: F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai<br/> Scand. J. Immunol., 2017-06-01;0(0):.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Human" data-application="Surface Plasmon Resonance" data-sampletype="Protein"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/27389696"> PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-?1 Pathway </a> </span><br/> PLoS ONE, 2016-07-07;11(7):e0158050.<br/> Species: Human<br/> Sample Types: Protein<br/> Applications: Surface Plasmon Resonance </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25658916"> A cationic-independent mannose 6-phosphate receptor inhibitor (PXS64) ameliorates kidney fibrosis by inhibiting activation of transforming growth factor-beta1. </a> </span><br/> Authors: Zhang J, Wong M, Wong M, Gross S, Chen J, Pollock C, Saad S<br/> PLoS ONE, 2015-02-06;10(2):e0116888.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <div id="ds_extra_cits"> <li class="top-lined" data-species="Human" data-application="Surface Plasmon Resonance" data-sampletype="Protein"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/25548275"> Induction and activation of latent transforming growth factor-beta1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1). </a> </span><br/> Authors: Ballesteros A, Mentink-Kane M, Warren J, Kaplan G, Dveksler G<br/> J Biol Chem, 2014-12-29;290(7):4422-31.<br/> Species: Human<br/> Sample Types: Protein<br/> Applications: Surface Plasmon Resonance </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24727589"> Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-beta signaling. </a> </span><br/> Authors: Tulley S, Chen W<br/> J Biol Chem, 2014-04-13;289(22):15280-96.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24162774"> The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-beta1 production and FcRL4 expression. </a> </span><br/> Authors: Jelicic K, Cimbro R, Nawaz F, Huang D, Zheng X, Yang J, Lempicki R, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang I, Kehrl J, Arthos J, Cicala C, Fauci A<br/> Nat Immunol, 2013-10-27;14(12):1256-65.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Mouse" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/24081879"> Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. </a> </span><br/> Authors: Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N<br/> Circ Res, 2013-09-30;113(12):1331-44.<br/> Species: Mouse<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="Porcine" data-application="Activation" data-sampletype="Protein"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/22005303"> Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. </a> </span><br/> Authors: Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y<br/> J. Clin. Invest., 2011-10-17;121(11):4548-66.<br/> Species: Porcine<br/> Sample Types: Protein<br/> Applications: Activation </li> <li class="top-lined" data-species="Human" data-application="Cell Culture" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/21535875"> IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-beta1 resulting in epithelial to mesenchymal transition. </a> </span><br/> Authors: Walsh L, Damjanovski S<br/> Cell Commun Signal, 2011-05-02;9(1):10.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Cell Culture </li> <li class="top-lined" data-species="Human" data-application="Binding Assay" data-sampletype="Recombinant Protein"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/19750484"> Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. </a> </span><br/> Authors: Stockis J, Colau D, Coulie PG, Lucas S<br/> Eur. J. Immunol., 2009-12-01;39(12):3315-22.<br/> Species: Human<br/> Sample Types: Recombinant Protein<br/> Applications: Binding Assay </li> <li class="top-lined" data-species="Human" data-application="Bioassay" data-sampletype="Whole Cells"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/18199553"> Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. </a> </span><br/> Authors: Van Aarsen LA, Leone DR, Ho S, Dolinski BM, McCoon PE, LePage DJ, Kelly R, Heaney G, Rayhorn P, Reid C, Simon KJ, Horan GS, Tao N, Gardner HA, Skelly MM, Gown AM, Thomas GJ, Weinreb PH, Fawell SE, Violette SM<br/> Cancer Res., 2008-01-15;68(2):561-70.<br/> Species: Human<br/> Sample Types: Whole Cells<br/> Applications: Bioassay </li> <li class="top-lined" data-species="" data-application="Western Blot" data-sampletype="NA"> <span class="ctitle"> <a target="_blank" rel="noreferrer nofollow" class="safe_link" href="//www.ncbi.nlm.nih.gov/pubmed/15100322"> Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. </a> </span><br/> Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ<br/> J. Immunol., 2004-05-01;172(9):5753-64.<br/> Applications: Western Blot </li> </div> </ol> </div> <div class="clearfix"><button class="btn btn-quinary ds_extra_cits pull-right toggle_cits_down" id="toggle_cits"></button></div> </div> </div> <div class="tab_content tab_4" data-tab="4" data-tabname="product-faqs" id="product-faqs"> <h2>FAQs</h2> <div class="row"> <div class="col-xs-12"> <p>No product specific FAQs exist for this product, however you may</p> <a class="btn btn-quinary view_all_faqs_btn" href="/resources/faqs/proteins-and-enzymes"> View all Proteins and Enzyme FAQs </a> </div> </div> </div> <div class="tab_content tab_6" data-tab="6" data-tabname="product-reviews" id="reviews"> <h3>Reviews for Recombinant Human Latent TGF-beta 1 Protein</h3> <div class="row"> <div class="col-xs-12"> <div class="datasheet_section"> <div class="row"> <div class="col-md-6"> <p> Average Rating: 5 <span class="review_stars_5"></span> (Based on 3 Reviews) </p> <div class="review_rating_progress"> <div class="row"> <div class="col-xs-3"> 5 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="100" aria-valuemin="0" aria-valuemax="100" style="width:100%"> </div> </div> </div> <div class="col-xs-3"> 100% </div> </div> <div class="row"> <div class="col-xs-3"> 4 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 3 Star </div> <div class="col-xs-6"> <div class="progress"> <div class="progress-bar progress-bar-warning" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100" style="width:0%"> </div> </div> </div> <div class="col-xs-3"> 0% </div> </div> <div class="row"> <div class="col-xs-3"> 2 Star </div> <div class="col-xs-6"> <div 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</div> </div> </div> <div class="row"> <div class="col-md-12"> <div class="reviews_filters"> <p style="display:inline;"><b>Filter by:</b></p> <div class="select_wrapper"> <select class="review_filter_rating"> <option value="all">All Ratings</option> <option value="5">5</option> </select> </div> <div class="select_wrapper"> <select class="review_filter_application"> <option value="all">All Applications</option> <option value="Immunoassay Standard"> Immunoassay Standard </option> <option value="In vitro bioactivity in cell culture"> In vitro bioactivity in cell culture </option> <option value="Media additive for protein or antibody production"> Media additive for protein or antibody production </option> </select> </div> </div> </div> </div> <br/> <div class="review_row" data-rating="5" data-species="" data-application="Immunoassay Standard"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Recombinant Human Latent TGF-beta 1 Protein</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 03/29/2019 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> Immunoassay Standard </span> </div> </div> <div class="review_how_used"><p>coated a 96 well plate with 0.5mg/mL of rh LAP-1 to confirm specificity of antibody BAM2462 to LAP-1 and not mature TGF beta 1 or mouse latent TGF beta (from a competitor)</p></div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_299-lt_41981_0.jpg" data-title="Immunoassay Standard Recombinant Human Latent TGF-beta 1 Protein 299-LT" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="Immunoassay Standard Recombinant Human Latent TGF-beta 1 Protein 299-LT" title="Immunoassay Standard Recombinant Human Latent TGF-beta 1 Protein 299-LT" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_299-lt_41981_0.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application="In vitro bioactivity in cell culture"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Recombinant Human Latent TGF-beta 1 Protein</div> <div class="review_date">By <span class="review_reviewer">Denis Streltsov</span> on 11/21/2018 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> In vitro bioactivity in cell culture </span> <br/><span class="ds_review_data"> <strong>Reason for Rating: </strong> consistent and robust response in assay models </span> </div> </div> </div> <div class="col-xs-12 col-sm-2"> <a class="ds-image" data-toggle="lightbox" href="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_299-lt-025_37461_0.jpg" data-title="In vitro bioactivity in cell culture Recombinant Human Latent TGF-beta 1 Protein 299-LT" data-gallery="Review-images"> <img loading="lazy" class="img-fluid review_image" alt="In vitro bioactivity in cell culture Recombinant Human Latent TGF-beta 1 Protein 299-LT" title="In vitro bioactivity in cell culture Recombinant Human Latent TGF-beta 1 Protein 299-LT" src="https://www.rndsystems.com/sites/rndsystems.com/files/reviews/review_299-lt-025_37461_0.jpg"/> </a> </div> </div> <hr/> </div> <div class="review_row" data-rating="5" data-species="" data-application="Media additive for protein or antibody production"> <div class="row"> <div class="col-xs-12 col-sm-10"> <div class="review_title review_stars_5">Recombinant Human Latent TGF-beta 1 Protein</div> <div class="review_date">By <span class="review_reviewer">Anonymous</span> on 01/13/2016 </div> <div class="row"> <div class="review_specifics col-xs-12"> <span class="ds_review_data"> <strong>Application:</strong> Media additive for protein or antibody production </span> <br/><span class="ds_review_data"> <strong>Reason for Rating: </strong> Performed as expected. R&D makes reliable products. </span> </div> </div> </div> </div> <hr/> </div> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="distributor_region"></div> <div class="widget"> <div class="widget_title">Related Products</div> <div class="widget_content" id="related_products_area"> <ul class="ds_details"> <li> <a href="/target/tgf-beta-1"> All Products for TGF-beta 1 </a> </li> <li> <a href="/target/tgf-beta-1?category=Proteins%20and%20Enzymes"> TGF-beta 1 Proteins and Enzymes </a> </li> <li> <a href="/target/tgf-beta-1?category=Primary%20Antibodies"> TGF-beta 1 Primary Antibodies </a> </li> <li> <a href="/target/tgf-beta-1?category=ELISAs"> TGF-beta 1 ELISAs </a> </li> <li> <a href="/target/tgf-beta-1?category=Simple%20Plex%20Assays"> TGF-beta 1 Simple Plex Assays </a> </li> <li> <a href="/target/tgf-beta-1?category=cDNA%20Clones"> TGF-beta 1 cDNA Clones </a> </li> <li> <a href="/target/tgf-beta-1?category=Luminex%20Assays"> 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Recombinant Human Latent TGF-beta 1 Protein 299-LT-005: R&D Systems