Caffeine from four cups of coffee protects the heart with the help of mitochondria -- ScienceDaily

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headlines</a></strong>!</div> </div> </div>  </header><div id="contents" class="container white"> <div class="row">  <div class="col-sm-8 main less-padding-right hyphenate">  <div class="head no-print"> <div class="pull-left head-left">Science News</div> <div class="pull-right head-right">from research organizations</div> </div> <div class="clearfix"></div> <hr class="head-rule no-print"/> <h1 id="headline" class="headline">Caffeine from four cups of coffee protects the heart with the help of mitochondria</h1> <dl class="dl-horizontal dl-custom"> <dt>Date:</dt> <dd id="date_posted">June 21, 2018</dd> <dt>Source:</dt> <dd id="source">PLOS</dd> <dt>Summary:</dt> <dd id="abstract">A new study shows that a caffeine concentration equivalent to four cups of coffee promotes the movement of a regulatory protein into mitochondria, enhancing their function and protecting cardiovascular cells from damage. </dd> <dt class="no-print">Share:</dt> <dd class="no-print"> <div id="share_top"> <div data-url="https://web.archive.org/web/20180630132632oe_/https://www.sciencedaily.com/releases/2018/06/180621141008.htm" class="ssk-sm ssk-group"> <a class="ssk ssk-icon ssk-facebook"></a> <a class="ssk ssk-icon ssk-twitter"></a> <a class="ssk ssk-icon ssk-google-plus"></a> <a class="ssk ssk-icon ssk-pinterest"></a> <a class="ssk ssk-icon ssk-linkedin"></a> <a class="ssk ssk-icon ssk-email"></a> </div> </div> </dd> </dl> <div class="row"> <div class="col-md-8 col-md-push-4"> <div class="fullstory">FULL STORY</div> <hr class="hr-fullstory"/> <div id="story_photo" class="hyphenate"> <div class="photo-image"><img class="img-responsive center-block" src="/web/20180630132632im_/https://www.sciencedaily.com/images/2018/06/180621141008_1_540x360.jpg" width="" height="" title="Click to enlarge" alt="" data-toggle="modal" data-target="#myModal"/></div> <div class="photo-caption">Coffee with caffeine.</div> <div class="photo-credit"><em>Credit: © Romolo Tavani / Fotolia</em></div> <div class="clearfix"></div>  <div class="modal fade" id="myModal" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" aria-hidden="true"> <div class="modal-dialog modal-lg"> <div class="modal-content modal-content-custom"> <div class="modal-image"><img class="img-responsive center-block" src="/web/20180630132632im_/https://www.sciencedaily.com/images/2018/06/180621141008_1_900x600.jpg" width="900" height="449"/></div> <div class="modal-text"> <div class="modal-caption">Coffee with caffeine.</div> <div class="modal-credit"><em>Credit: © Romolo Tavani / Fotolia</em></div> <div class="modal-close"><button type="button" class="btn btn-default" data-dismiss="modal">Close</button></div> <div class="clearfix"></div> </div> </div> </div> </div> </div>  <div class="clearfix"></div> <div id="story_text" class="hyphenate"> <p id="first" class="lead">Caffeine consumption has been associated with lower risks for multiple diseases, including type II diabetes, heart disease, and stroke, but the mechanism underlying these protective effects has been unclear. A new study now shows that caffeine promotes the movement of a regulatory protein into mitochondria, enhancing their function and protecting cardiovascular cells from damage. The work, publishing 21 June in the open access journal <em>PLOS Biology</em>, by Judith Haendeler and Joachim Altschmied of the Medical Faculty, Heinrich-Heine-University and the IUF-Leibniz Research Institute for Environmental Medicine in Duesseldorf, Germany, and colleagues, found that the protective effect was reached at a concentration equivalent to consumption of four cups of coffee, suggesting the effect may be physiologically relevant.</p> <div class="mobile-top-rectangle hidden-md hidden-lg"> <div class="textrule"> <span>advertisement</span> </div>  <div id="adslot-mobile-top-rectangle"> <script type="text/javascript"> googletag.cmd.push(function() { deployads.push(function() { deployads.gpt.display("adslot-mobile-top-rectangle") }); }); </script> </div> <hr class="hrrule"/> </div> <div id="text"> <p>The authors have previously shown that at physiologically relevant concentrations (i.e. levels reached after four or more cups of coffee) caffeine improved the functional capacity of endothelial cells, which line the interior of blood vessels, and that the effect involved mitochondria, the cell's energy powerhouses.</p> <p>Here, they showed that a protein called p27, known mainly as an inhibitor of the cell cycle, was present in mitochondria in the major cell types of the heart. In these cells, mitochondrial p27 promoted migration of endothelial cells, protected heart muscle cells from cell death, and triggered the conversion of fibroblasts into cells containing contractile fibers -- all crucial for repair of heart muscle after myocardial infarction. They found that caffeine induced the movement of p27 into mitochondria, setting off this beneficial chain of events, and did so at a concentration that is reached in humans by drinking four cups of coffee. Caffeine was protective against heart damage in pre-diabetic, obese mice, and in aged mice.</p> <p>"Our results indicate a new mode of action for caffeine," said Haendeler, "one that promotes protection and repair of heart muscle through the action of mitochondrial p27. These results should lead to better strategies for protecting heart muscle from damage, including consideration of coffee consumption or caffeine as an additional dietary factor in the elderly population. Furthermore, enhancing mitochondrial p27 could serve as a potential therapeutic strategy not only in cardiovascular diseases but also in improving healthspan."</p> </div> <div class="mobile-middle-rectangle hidden-md hidden-lg"> <div class="textrule"> <span>advertisement</span> </div>  <div id="adslot-mobile-middle-rectangle"> <script type="text/javascript"> googletag.cmd.push(function() { deployads.push(function() { deployads.gpt.display("adslot-mobile-middle-rectangle") }); }); </script> </div> <hr class="hrrule"/> </div> <hr class="hidden-sm hidden-xs"/> <div id="story_source"> <p><strong>Story Source:</strong></p> <p>Materials provided by <a href="https://web.archive.org/web/20180630132632/http://www.plos.org/" rel="nofollow" target="_blank"><strong>PLOS</strong></a>. <em>Note: Content may be edited for style and length.</em></p> </div>  <hr/> <div id="journal_references"><p><strong>Journal Reference</strong>:</p> <ol class="journal"> <li>Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Ioakim Spyridopoulos, Stefanie Gonnissen, Nadine Dyballa-Rukes, Karin Aufenvenne, Florian von Ameln, Mark Zurek, Tim Spannbrucker, Olaf Eckermann, Sascha Jakob, Simone Gorressen, Marcel Abrams, Maria Grandoch, Jens W. Fischer, Karl Köhrer, René Deenen, Klaus Unfried, Joachim Altschmied, Judith Haendeler. <strong>CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine</strong>. <em>PLOS Biology</em>, 2018; 16 (6): e2004408 DOI: <a href="https://web.archive.org/web/20180630132632/http://dx.doi.org/10.1371/journal.pbio.2004408" rel="nofollow" target="_blank">10.1371/journal.pbio.2004408</a> </li> </ol> <hr/> </div>  <div id="citations"> <div role="tabpanel" class="right-tabs clearfix"> <p class="pull-left"><strong>Cite This Page</strong>:</p>  <ul class="nav nav-tabs" role="tablist"> <li role="presentation" class="active"><a href="#citation_mla" aria-controls="citation_mla" role="tab" data-toggle="tab">MLA</a></li> <li role="presentation"><a href="#citation_apa" aria-controls="citation_apa" role="tab" data-toggle="tab">APA</a></li> <li role="presentation"><a href="#citation_chicago" aria-controls="citation_chicago" role="tab" data-toggle="tab">Chicago</a></li> </ul> <div class="tab-content tab-citations"> <div role="tabpanel" class="tab-pane active" id="citation_mla">PLOS. "Caffeine from four cups of coffee protects the heart with the help of mitochondria." ScienceDaily. ScienceDaily, 21 June 2018. <www.sciencedaily.com/releases/2018/06/180621141008.htm>.</div> <div role="tabpanel" class="tab-pane" id="citation_apa">PLOS. (2018, June 21). Caffeine from four cups of coffee protects the heart with the help of mitochondria. <em>ScienceDaily</em>. Retrieved June 30, 2018 from www.sciencedaily.com/releases/2018/06/180621141008.htm</div> <div role="tabpanel" class="tab-pane" id="citation_chicago">PLOS. "Caffeine from four cups of coffee protects the heart with the help of mitochondria." 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