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vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Fonction_dans_les_protéines"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Fonction dans les protéines</span> </div> </a> <ul id="toc-Fonction_dans_les_protéines-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Autres_rôles" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Autres_rôles"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Autres rôles</span> </div> </a> <button aria-controls="toc-Autres_rôles-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Autres rôles</span> </button> <ul id="toc-Autres_rôles-sublist" class="vector-toc-list"> <li id="toc-Purification_par_chromatographie_d'affinité_métallique" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Purification_par_chromatographie_d'affinité_métallique"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Purification par chromatographie d'affinité métallique</span> </div> </a> <ul id="toc-Purification_par_chromatographie_d'affinité_métallique-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dérivés_de_l'histidine" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dérivés_de_l'histidine"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Dérivés de l'histidine</span> </div> </a> <ul id="toc-Dérivés_de_l'histidine-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Présence_dans_le_corps_humain" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Présence_dans_le_corps_humain"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Présence dans le corps humain</span> </div> </a> <ul id="toc-Présence_dans_le_corps_humain-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Propriétés_chimiques_et_physiques" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Propriétés_chimiques_et_physiques"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Propriétés chimiques et physiques</span> </div> </a> <ul id="toc-Propriétés_chimiques_et_physiques-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Notes_et_références" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Notes_et_références"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Notes et références</span> </div> </a> <ul id="toc-Notes_et_références-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liens_externes" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Liens_externes"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Liens externes</span> </div> </a> <ul id="toc-Liens_externes-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sommaire" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Basculer la table des matières" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Basculer la table des matières</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Histidine</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 60 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-60" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">60 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%87%D8%B3%D8%AA%D9%8A%D8%AF%D9%8A%D9%86" title="هستيدين – arabe" lang="ar" hreflang="ar" data-title="هستيدين" data-language-autonym="العربية" data-language-local-name="arabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%87%DB%8C%D8%B3%D8%AA%DB%8C%D8%AF%DB%8C%D9%86" title="هیستیدین – South Azerbaijani" lang="azb" hreflang="azb" data-title="هیستیدین" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%93%D1%96%D1%81%D1%82%D1%8B%D0%B4%D1%8B%D0%BD" title="Гістыдын – biélorusse" lang="be" hreflang="be" data-title="Гістыдын" data-language-autonym="Беларуская" data-language-local-name="biélorusse" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Хистидин – bulgare" lang="bg" hreflang="bg" data-title="Хистидин" data-language-autonym="Български" data-language-local-name="bulgare" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Histidin" title="Histidin – bosniaque" lang="bs" hreflang="bs" data-title="Histidin" data-language-autonym="Bosanski" data-language-local-name="bosniaque" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Histidina" title="Histidina – catalan" lang="ca" hreflang="ca" data-title="Histidina" data-language-autonym="Català" data-language-local-name="catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Histidin" title="Histidin – tchèque" lang="cs" hreflang="cs" data-title="Histidin" data-language-autonym="Čeština" data-language-local-name="tchèque" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Histidin" title="Histidin – danois" lang="da" hreflang="da" data-title="Histidin" data-language-autonym="Dansk" data-language-local-name="danois" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Histidin" title="Histidin – allemand" lang="de" hreflang="de" data-title="Histidin" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%99%CF%83%CF%84%CE%B9%CE%B4%CE%AF%CE%BD%CE%B7" title="Ιστιδίνη – grec" lang="el" hreflang="el" data-title="Ιστιδίνη" data-language-autonym="Ελληνικά" data-language-local-name="grec" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Histidine" title="Histidine – anglais" lang="en" hreflang="en" data-title="Histidine" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Histidino" title="Histidino – espéranto" lang="eo" hreflang="eo" data-title="Histidino" data-language-autonym="Esperanto" data-language-local-name="espéranto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Histidina" title="Histidina – espagnol" lang="es" hreflang="es" data-title="Histidina" data-language-autonym="Español" data-language-local-name="espagnol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Histidiin" title="Histidiin – estonien" lang="et" hreflang="et" data-title="Histidiin" data-language-autonym="Eesti" data-language-local-name="estonien" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Histidina" title="Histidina – basque" lang="eu" hreflang="eu" data-title="Histidina" data-language-autonym="Euskara" data-language-local-name="basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%87%DB%8C%D8%B3%D8%AA%DB%8C%D8%AF%DB%8C%D9%86" title="هیستیدین – persan" lang="fa" hreflang="fa" data-title="هیستیدین" data-language-autonym="فارسی" data-language-local-name="persan" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Histidiini" title="Histidiini – finnois" lang="fi" hreflang="fi" data-title="Histidiini" data-language-autonym="Suomi" data-language-local-name="finnois" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Histidina" title="Histidina – galicien" lang="gl" hreflang="gl" data-title="Histidina" data-language-autonym="Galego" data-language-local-name="galicien" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%94%D7%99%D7%A1%D7%98%D7%99%D7%93%D7%99%D7%9F" title="היסטידין – hébreu" lang="he" hreflang="he" data-title="היסטידין" data-language-autonym="עברית" data-language-local-name="hébreu" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%B9%E0%A4%BF%E0%A4%B8%E0%A5%8D%E0%A4%9F%E0%A4%BF%E0%A4%A1%E0%A4%BF%E0%A4%A8" title="हिस्टिडिन – hindi" lang="hi" hreflang="hi" data-title="हिस्टिडिन" data-language-autonym="हिन्दी" data-language-local-name="hindi" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Histidin" title="Histidin – croate" lang="hr" hreflang="hr" data-title="Histidin" data-language-autonym="Hrvatski" data-language-local-name="croate" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Hisztidin" title="Hisztidin – hongrois" lang="hu" hreflang="hu" data-title="Hisztidin" data-language-autonym="Magyar" data-language-local-name="hongrois" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%80%D5%AB%D5%BD%D5%BF%D5%AB%D5%A4%D5%AB%D5%B6" title="Հիստիդին – arménien" lang="hy" hreflang="hy" data-title="Հիստիդին" data-language-autonym="Հայերեն" data-language-local-name="arménien" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Histidina" title="Histidina – indonésien" lang="id" hreflang="id" data-title="Histidina" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonésien" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Istidina" title="Istidina – italien" lang="it" hreflang="it" data-title="Istidina" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%92%E3%82%B9%E3%83%81%E3%82%B8%E3%83%B3" title="ヒスチジン – japonais" lang="ja" hreflang="ja" data-title="ヒスチジン" data-language-autonym="日本語" data-language-local-name="japonais" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%B0%E1%83%98%E1%83%A1%E1%83%A2%E1%83%98%E1%83%93%E1%83%98%E1%83%9C%E1%83%98" title="ჰისტიდინი – géorgien" lang="ka" hreflang="ka" data-title="ჰისტიდინი" data-language-autonym="ქართული" data-language-local-name="géorgien" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%93%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Гистидин – kazakh" lang="kk" hreflang="kk" data-title="Гистидин" data-language-autonym="Қазақша" data-language-local-name="kazakh" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%ED%9E%88%EC%8A%A4%ED%8B%B0%EB%94%98" title="히스티딘 – coréen" lang="ko" hreflang="ko" data-title="히스티딘" data-language-autonym="한국어" data-language-local-name="coréen" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-lb mw-list-item"><a href="https://lb.wikipedia.org/wiki/Histidin" title="Histidin – luxembourgeois" lang="lb" hreflang="lb" data-title="Histidin" data-language-autonym="Lëtzebuergesch" data-language-local-name="luxembourgeois" class="interlanguage-link-target"><span>Lëtzebuergesch</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Histidinas" title="Histidinas – lituanien" lang="lt" hreflang="lt" data-title="Histidinas" data-language-autonym="Lietuvių" data-language-local-name="lituanien" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Histid%C4%ABns" title="Histidīns – letton" lang="lv" hreflang="lv" data-title="Histidīns" data-language-autonym="Latviešu" data-language-local-name="letton" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Хистидин – macédonien" lang="mk" hreflang="mk" data-title="Хистидин" data-language-autonym="Македонски" data-language-local-name="macédonien" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Histidina" title="Histidina – malais" lang="ms" hreflang="ms" data-title="Histidina" data-language-autonym="Bahasa Melayu" data-language-local-name="malais" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Histidine" title="Histidine – néerlandais" lang="nl" hreflang="nl" data-title="Histidine" data-language-autonym="Nederlands" data-language-local-name="néerlandais" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Histidin" title="Histidin – norvégien nynorsk" lang="nn" hreflang="nn" data-title="Histidin" data-language-autonym="Norsk nynorsk" data-language-local-name="norvégien nynorsk" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Histidin" title="Histidin – norvégien bokmål" lang="nb" hreflang="nb" data-title="Histidin" data-language-autonym="Norsk bokmål" data-language-local-name="norvégien bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Istidina" title="Istidina – occitan" lang="oc" hreflang="oc" data-title="Istidina" data-language-autonym="Occitan" data-language-local-name="occitan" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Histydyna" title="Histydyna – polonais" lang="pl" hreflang="pl" data-title="Histydyna" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D9%87%D8%B3%D9%BC%D8%A7%D9%8A%DA%89%D9%8A%D9%86" title="هسټايډين – pachto" lang="ps" hreflang="ps" data-title="هسټايډين" data-language-autonym="پښتو" data-language-local-name="pachto" class="interlanguage-link-target"><span>پښتو</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Histidina" title="Histidina – portugais" lang="pt" hreflang="pt" data-title="Histidina" data-language-autonym="Português" data-language-local-name="portugais" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Histidin%C4%83" title="Histidină – roumain" lang="ro" hreflang="ro" data-title="Histidină" data-language-autonym="Română" data-language-local-name="roumain" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%93%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Гистидин – russe" lang="ru" hreflang="ru" data-title="Гистидин" data-language-autonym="Русский" data-language-local-name="russe" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-scn mw-list-item"><a href="https://scn.wikipedia.org/wiki/Istidina" title="Istidina – sicilien" lang="scn" hreflang="scn" data-title="Istidina" data-language-autonym="Sicilianu" data-language-local-name="sicilien" class="interlanguage-link-target"><span>Sicilianu</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Histidin" title="Histidin – serbo-croate" lang="sh" hreflang="sh" data-title="Histidin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Histidine" title="Histidine – Simple English" lang="en-simple" hreflang="en-simple" data-title="Histidine" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Histid%C3%ADn" title="Histidín – slovaque" lang="sk" hreflang="sk" data-title="Histidín" data-language-autonym="Slovenčina" data-language-local-name="slovaque" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Histidin" title="Histidin – slovène" lang="sl" hreflang="sl" data-title="Histidin" data-language-autonym="Slovenščina" data-language-local-name="slovène" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%A5%D0%B8%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Хистидин – serbe" lang="sr" hreflang="sr" data-title="Хистидин" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-su mw-list-item"><a href="https://su.wikipedia.org/wiki/Histidin" title="Histidin – soundanais" lang="su" hreflang="su" data-title="Histidin" data-language-autonym="Sunda" data-language-local-name="soundanais" class="interlanguage-link-target"><span>Sunda</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Histidin" title="Histidin – suédois" lang="sv" hreflang="sv" data-title="Histidin" data-language-autonym="Svenska" data-language-local-name="suédois" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%B9%E0%AE%BF%E0%AE%B8%E0%AF%8D%E0%AE%9F%E0%AE%BF%E0%AE%9F%E0%AE%BF%E0%AE%A9%E0%AF%8D" title="ஹிஸ்டிடின் – tamoul" lang="ta" hreflang="ta" data-title="ஹிஸ்டிடின்" data-language-autonym="தமிழ்" data-language-local-name="tamoul" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Histidin" title="Histidin – turc" lang="tr" hreflang="tr" data-title="Histidin" data-language-autonym="Türkçe" data-language-local-name="turc" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%93%D1%96%D1%81%D1%82%D0%B8%D0%B4%D0%B8%D0%BD" title="Гістидин – ukrainien" lang="uk" hreflang="uk" data-title="Гістидин" data-language-autonym="Українська" data-language-local-name="ukrainien" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Gistidin" title="Gistidin – ouzbek" lang="uz" hreflang="uz" data-title="Gistidin" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="ouzbek" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Histidin" title="Histidin – vietnamien" lang="vi" hreflang="vi" data-title="Histidin" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamien" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E7%BB%84%E6%B0%A8%E9%85%B8" title="组氨酸 – wu" lang="wuu" hreflang="wuu" data-title="组氨酸" data-language-autonym="吴语" data-language-local-name="wu" class="interlanguage-link-target"><span>吴语</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%B5%84%E6%B0%A8%E9%85%B8" title="組氨酸 – chinois" lang="zh" hreflang="zh" data-title="組氨酸" data-language-autonym="中文" data-language-local-name="chinois" class="interlanguage-link-target"><span>中文</span></a></li><li class="interlanguage-link interwiki-zh-min-nan mw-list-item"><a href="https://zh-min-nan.wikipedia.org/wiki/Histidin" title="Histidin – minnan" lang="nan" hreflang="nan" data-title="Histidin" data-language-autonym="閩南語 / Bân-lâm-gú" data-language-local-name="minnan" class="interlanguage-link-target"><span>閩南語 / Bân-lâm-gú</span></a></li><li class="interlanguage-link interwiki-zh-yue mw-list-item"><a href="https://zh-yue.wikipedia.org/wiki/%E7%B5%84%E6%B0%A8%E9%85%B8" title="組氨酸 – cantonais" lang="yue" hreflang="yue" data-title="組氨酸" data-language-autonym="粵語" data-language-local-name="cantonais" class="interlanguage-link-target"><span>粵語</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span 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<table class="infobox_v2 infobox infobox--frwiki noarchive"> <tbody><tr> <td colspan="2" class="entete defaut" style="background-color:#FFDEAD;color:black;">Histidine </td></tr> <tr><td colspan="2" style="display:none;"> </td></tr> <tr> <td colspan="2" style="text-align:center;"><span typeof="mw:File"><a href="/wiki/Fichier:L-Histidin_-_L-Histidine.svg" class="mw-file-description" title="L-Histidine"><img alt="L-Histidine" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/L-Histidin_-_L-Histidine.svg/175px-L-Histidin_-_L-Histidine.svg.png" decoding="async" width="175" height="96" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/L-Histidin_-_L-Histidine.svg/263px-L-Histidin_-_L-Histidine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/18/L-Histidin_-_L-Histidine.svg/350px-L-Histidin_-_L-Histidine.svg.png 2x" data-file-width="229" data-file-height="125" /></a></span><br /><b>L ou <i>S</i>(–)-histidine</b><br /><br /><span typeof="mw:File"><a href="/wiki/Fichier:D-Histidine.svg" class="mw-file-description" title="D-Histidine"><img alt="D-Histidine" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/D-Histidine.svg/175px-D-Histidine.svg.png" decoding="async" width="175" height="102" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/D-Histidine.svg/263px-D-Histidine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/D-Histidine.svg/350px-D-Histidine.svg.png 2x" data-file-width="222" data-file-height="130" /></a></span><br /><b>D ou <i>R</i>(+)-histidine</b></td> </tr><tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Identification</th></tr> <tr> <th scope="row"><a href="/wiki/Nomenclature_de_l%27UICPA" title="Nomenclature de l'UICPA">Nom UICPA</a> </th> <td><small>acide 2-amino-3-(1H-imidazol-4-yl)propanoïque</small> </td> </tr> <tr> <th scope="row"><a href="/wiki/Synonymie" title="Synonymie">Synonymes</a> </th> <td> <p>H, His </p> </td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CAS" title="Numéro CAS">N<sup>o</sup> CAS</a> </th> <td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=4998-57-6&language=fr&title=Histidine">4998-57-6</a></span></span> (racémique)<br /><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=71-00-1&language=fr&title=Histidine">71-00-1</a></span></span> (L) ou <i>S</i>(–)<br /><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="//tools.wmflabs.org/magnustools/cas.php?cas=351-50-8&language=fr&title=Histidine">351-50-8</a></span></span> (D) ou <i>R</i>(+) </td> </tr> <tr> <th scope="row"> N<sup>o</sup> <a href="/wiki/Agence_europ%C3%A9enne_des_produits_chimiques" title="Agence européenne des produits chimiques">ECHA</a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.000.678">100.000.678</a></span></span></td> </tr> <tr> <th scope="row"><a href="/wiki/Num%C3%A9ro_CE" title="Numéro CE">N<sup>o</sup> CE</a> </th> <td>200-745-3<br />206-513-8 (D) </td> </tr> <tr> <th scope="row"><a href="/wiki/GRAS" class="mw-redirect" title="GRAS"><span title="Flavor and Extract Manufacturers Association">FEMA</span></a> </th> <td><span class="plainlinks"><span class="noarchive"><a rel="nofollow" class="external text" href="http://www.fao.org/ag/agn/jecfa-flav/results.html?flavName=&groupName=-1&searchBy=fema&jecfa=&fema=3694&cas1=&cas2=&cas3="><span title="laevo-histidine">3694</span></a></span></span> </td> </tr> <tr> <th scope="row"><a href="/wiki/Simplified_Molecular_Input_Line_Entry_System" title="Simplified Molecular Input Line Entry System">SMILES</a> </th> <td><div class="NavFrame" title="[Afficher]/[Masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;">NC(Cc1cncn1)C(=O)O <br /><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/search/?smarts=NC%28Cc1cncn1%29C%28%3DO%29O">PubChem</a></span>, <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=Histidine&model=NC%28Cc1cncn1%29C%28%3DO%29O">vue 3D</a></span></div></div> </td> </tr> <tr> <th scope="row"><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a> </th> <td><div class="NavFrame" title="[Afficher]/[Masquer]" style="border: none; padding: 0;"><div class="NavContent" style="display: none; text-align: left;"><b>InChI :</b> <span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://chemapps.stolaf.edu/jmol/jmol.php?title=Histidine&model=InChI%3D1%2FC6H9N3O2%2Fc7-5%286%2810%2911%291-4-2-8-3-9-4%2Fh2-3%2C5H%2C1%2C7H2%2C%28H%2C8%2C9%29%28H%2C10%2C11%29">vue 3D</a></span> <br />InChI=1/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11) <br /></div></div> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Propriétés chimiques</th></tr> <tr> <th scope="row"><a href="/wiki/Formule_chimique" title="Formule chimique">Formule</a> </th> <td><a href="/wiki/Carbone" title="Carbone">C</a><sub>6</sub><a href="/wiki/Hydrog%C3%A8ne" title="Hydrogène">H</a><sub>9</sub><a href="/wiki/Azote" title="Azote">N</a><sub>3</sub><a href="/wiki/Oxyg%C3%A8ne" title="Oxygène">O</a><sub>2</sub>  <span class="page_h"><a href="/wiki/C6H9N3O2" class="mw-redirect" title="C6H9N3O2"><small>[Isomères]</small></a></span><br /> </td> </tr> <tr> <th scope="row"><a href="/wiki/Masse_molaire" title="Masse molaire">Masse molaire</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup> </th> <td>155,154 6 ± 0,006 6 <a href="/wiki/Gramme" title="Gramme">g</a>/<a href="/wiki/Mole_(unit%C3%A9)" title="Mole (unité)">mol</a> <br /><small>C 46,45 %,  H 5,85 %,  N 27,08 %,  O 20,62 %,  </small> </td> </tr> <tr> <th scope="row"><a href="/wiki/Constante_d%27acidit%C3%A9" title="Constante d'acidité">p<i>K</i><sub>a</sub></a> </th> <td>1,70<br />6,04<br />9,09 </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#f7efa8; color:#000000">Propriétés physiques</th></tr> <tr> <th scope="row"><a href="/wiki/Point_de_fusion" title="Point de fusion"><abbr class="abbr" title="Température">T°</abbr> fusion</a> </th> <td><span title="548,6 °F ou 560,2 K">287 </span><abbr class="abbr" title="degré Celsius">°C</abbr> </td> </tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#FFDEAD; color:#000000">Propriétés biochimiques</th></tr> <tr> <th scope="row"><a href="/wiki/Code_g%C3%A9n%C3%A9tique#Codons" title="Code génétique">Codons</a> </th> <td><a href="/wiki/Codon" title="Codon">CAU</a>, <a href="/wiki/Codon" title="Codon">CAC</a> </td> </tr> <tr> <th scope="row"><a href="/wiki/Point_iso%C3%A9lectrique" title="Point isoélectrique">pH isoélectrique</a> </th> <td>7,59<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup> </td> </tr> <tr> <th scope="row"><a href="/wiki/Acide_amin%C3%A9_essentiel" title="Acide aminé essentiel">Acide aminé essentiel</a> </th> <td>oui </td></tr><tr><th style="padding: 2px 0px;">Occurrence chez les <a href="/wiki/Vert%C3%A9br%C3%A9s" title="Vertébrés">vertébrés</a></th><td>2,9 %<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup></td></tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#ffb4b4; color:#000000">Précautions</th></tr> <tr> <th colspan="2" style="padding:4px; text-align:center; background-color:#eeeeee; color:#000000"><a href="/wiki/Syst%C3%A8me_d%27information_sur_les_mati%C3%A8res_dangereuses_utilis%C3%A9es_au_travail" title="Système d'information sur les matières dangereuses utilisées au travail">SIMDUT</a><sup id="cite_ref-Reptox_4-0" class="reference"><a href="#cite_note-Reptox-4"><span class="cite_crochet">[</span>4<span class="cite_crochet">]</span></a></sup></th></tr> <tr> <td colspan="2" style="text-align:center;"><br />Produit non contrôlé<div class="NavFrame" title="[+]/[–]" style="border:none; padding: 0;"><div class="NavContent" style="display:none; text-align:left;">Ce produit n'est pas contrôlé selon les critères de classification du SIMDUT.</div></div></td> </tr><tr> <td colspan="2"><hr style="height:2px; background-color:#FFDEAD;" /></td></tr> <tr> <td colspan="2" style="text-align:center;">Unités du <a href="/wiki/Syst%C3%A8me_international_d%27unit%C3%A9s" title="Système international d'unités">SI</a> et <a href="/wiki/Conditions_normales_de_temp%C3%A9rature_et_de_pression" title="Conditions normales de température et de pression"><abbr title="conditions normales de température et de pression">CNTP</abbr></a>, sauf indication contraire.</td> </tr><tr> <td class="navigation-only" colspan="2" style="border-top: 2px #FFDEAD solid; font-size: 80%; background:inherit; text-align: right;"><span class="plainlinks" style="float:left;"><a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Histidine&action=edit&section=0"><span class="infodoc">modifier</span></a></span> <span typeof="mw:File"><a href="/wiki/Mod%C3%A8le:Infobox_Chimie" title="Consultez la documentation du modèle"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></td> </tr> </tbody></table> <p>L'<b>histidine</b> (abréviations <a href="/wiki/Union_internationale_de_chimie_pure_et_appliqu%C3%A9e" title="Union internationale de chimie pure et appliquée">IUPAC</a>-<a href="/wiki/Union_internationale_de_biochimie_et_de_biologie_mol%C3%A9culaire" title="Union internationale de biochimie et de biologie moléculaire">IUBMB</a> : <b>His</b> et <b>H</b>), du <a href="/wiki/Grec_ancien" title="Grec ancien">grec ancien</a> <span class="lang-grc" lang="grc">ἱστός</span>, <span class="lang-grc" lang="grc">ἱστίον</span> (« <i>mât de navire</i> », « <i>métier à tisser</i> », « <i>voile de navire</i> »<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite_crochet">[</span>5<span class="cite_crochet">]</span></a></sup>)<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite_crochet">[</span>6<span class="cite_crochet">]</span></a></sup>, est un <a href="/wiki/Acide_amin%C3%A9" title="Acide aminé">acide <span class="nowrap">α-aminé</span></a> dont l'<a href="/wiki/%C3%89nantiom%C3%A9rie" title="Énantiomérie">énantiomère</a> <small>L</small> est l'un des <a href="/wiki/Acide_amin%C3%A9_prot%C3%A9inog%C3%A8ne" title="Acide aminé protéinogène">22 acides aminés protéinogènes</a>, l'un des <a href="/wiki/Acide_amin%C3%A9_essentiel" title="Acide aminé essentiel">9 acides aminés essentiels</a> et fait partie des acides aminés glucoformateur. Elle est <a href="/wiki/Code_g%C3%A9n%C3%A9tique" title="Code génétique">encodée</a> sur les <a href="/wiki/Acide_ribonucl%C3%A9ique_messager" title="Acide ribonucléique messager">ARN messagers</a> par les <a href="/wiki/Codon" title="Codon">codons</a> CAU et CAC. Elle est caractérisée par la présence d'un <a href="/wiki/Compos%C3%A9_cyclique" title="Composé cyclique">cycle</a> <a href="/wiki/Imidazole" title="Imidazole">imidazole</a> qui confère une nature <a href="/wiki/Base_(chimie)" title="Base (chimie)">basique</a> aux <a href="/wiki/R%C3%A9sidu_(biochimie)" title="Résidu (biochimie)">résidus</a> d'histidine dans les <a href="/wiki/Prot%C3%A9ine" title="Protéine">protéines</a>. Son <a href="/wiki/Rayon_de_van_der_Waals" title="Rayon de van der Waals">rayon de van der Waals</a> est égal à <span class="nowrap"><span title="11,8 nm">118</span> <span title="Ångström">Å</span></span>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Biosynthèse"><span id="Biosynth.C3.A8se"></span>Biosynthèse</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=1" title="Modifier la section : Biosynthèse" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=1" title="Modifier le code source de la section : Biosynthèse"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="bandeau-container bandeau-section metadata bandeau-niveau-information"><div class="bandeau-cell bandeau-icone"><span class="mw-valign-text-top noviewer" typeof="mw:File"><a href="/wiki/Fichier:Fairytale_warning.png" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/Fairytale_warning.png/17px-Fairytale_warning.png" decoding="async" width="17" height="17" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/Fairytale_warning.png/26px-Fairytale_warning.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/87/Fairytale_warning.png/34px-Fairytale_warning.png 2x" data-file-width="64" data-file-height="64" /></a></span></div><div class="bandeau-cell">Cette section est vide, insuffisamment détaillée ou incomplète. <a href="/wiki/Sp%C3%A9cial:EditPage/Histidine" title="Spécial:EditPage/Histidine">Votre aide</a> est la bienvenue ! <a href="/wiki/Aide:Comment_modifier_une_page" title="Aide:Comment modifier une page">Comment faire ?</a></div></div> <p>Contrairement aux <a href="/wiki/Micro-organisme" title="Micro-organisme">micro-organismes</a> et aux <a href="/wiki/Plante" title="Plante">plantes</a> qui sont capables de synthétiser l'histidine, les animaux en sont incapables. Leur seul moyen de s'en procurer se situe dans leur alimentation. Qualifiée chez l'humain adulte, comme étant un acide aminé semi-indispensable, il devient cependant indispensable chez l'enfant car l'histidine intervient dans les processus de croissance biologique<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite_crochet">[</span>7<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Fonction_dans_les_protéines"><span id="Fonction_dans_les_prot.C3.A9ines"></span>Fonction dans les protéines</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=2" title="Modifier la section : Fonction dans les protéines" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=2" title="Modifier le code source de la section : Fonction dans les protéines"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>L'histidine est un acide aminé qui remplit des fonctions importantes dans la <a href="/wiki/Structure_des_prot%C3%A9ines" title="Structure des protéines">structure</a> et la fonction des <a href="/wiki/Prot%C3%A9ine" title="Protéine">protéines</a>. Le noyau imidazole de l'histidine dispose d'un atome d'<a href="/wiki/Azote" title="Azote">azote</a> pouvant capter un <a href="/wiki/Proton" title="Proton">proton</a>, avec un <a href="/wiki/Constante_d%27%C3%A9quilibre" title="Constante d'équilibre">pKa</a> proche de la neutralité (pKa~6.8) et donc des conditions physiologiques. Cette propriété est cruciale pour la fonction de certaines protéines : </p> <ul><li>elle permet à certains résidus d'histidine présents dans les sites actifs d'<a href="/wiki/Enzyme" title="Enzyme">enzymes</a> d'intervenir dans des réactions de transfert de proton, dans les conditions physiologiques du <a href="/wiki/Cytoplasme" title="Cytoplasme">cytoplasme</a> (<a href="/wiki/Potentiel_hydrog%C3%A8ne" title="Potentiel hydrogène">pH</a>~7) ;</li> <li>dans l'<a href="/wiki/H%C3%A9moglobine" title="Hémoglobine">hémoglobine</a>, les histidines présentes dans la protéine participent au maintien du <a href="/wiki/Potentiel_hydrog%C3%A8ne" title="Potentiel hydrogène">pH</a> sanguin en agissant comme <a href="/wiki/Mol%C3%A9cule" title="Molécule">molécule</a> <a href="/wiki/Solution_tampon" title="Solution tampon">tampon</a>.</li></ul> <p>L'azote du cycle imidazole des histidines peut également former des <a href="/wiki/Liaison_chimique" title="Liaison chimique">liaisons</a> de coordination avec des ions métalliques comme Zn<sup>2+</sup>, Co<sup>2+</sup>, Fe<sup>2+</sup> ou Ni<sup>2+</sup>. Ces liaisons sont importantes pour la fixation de ces ions dans des <a href="/wiki/M%C3%A9talloprot%C3%A9ine" title="Métalloprotéine">métalloprotéines</a>, où la complexation du métal est requise pour l'activité de la protéine. On trouve par exemple une histidine comme ligand axial du <a href="/wiki/Fer" title="Fer">fer</a> dans la <a href="/wiki/Myoglobine" title="Myoglobine">myoglobine</a> et l'<a href="/wiki/H%C3%A9moglobine" title="Hémoglobine">hémoglobine</a> et deux histidines dans la complexation du <a href="/wiki/Zinc" title="Zinc">zinc</a> présent dans la <a href="/wiki/Collag%C3%A9nase" title="Collagénase">collagénase</a>, une <a href="/wiki/Prot%C3%A9ase" class="mw-redirect" title="Protéase">protéase</a> qui dégrade le <a href="/wiki/Collag%C3%A8ne" title="Collagène">collagène</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Autres_rôles"><span id="Autres_r.C3.B4les"></span>Autres rôles</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=3" title="Modifier la section : Autres rôles" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=3" title="Modifier le code source de la section : Autres rôles"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Purification_par_chromatographie_d'affinité_métallique"><span id="Purification_par_chromatographie_d.27affinit.C3.A9_m.C3.A9tallique"></span>Purification par chromatographie d'affinité métallique</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=4" title="Modifier la section : Purification par chromatographie d'affinité métallique" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=4" title="Modifier le code source de la section : Purification par chromatographie d'affinité métallique"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La propriété de fixation des ions métalliques par l'histidine est à la base d'une technologie de <a href="/wiki/Purification_des_prot%C3%A9ines" title="Purification des protéines">purification des protéines</a> recombinantes appelée <a href="/wiki/Chromatographie" title="Chromatographie">chromatographie</a> d'affinité pour ions métalliques immobilisés (<b>(en)</b> IMAC, pour <i>immobilized metal affinity chromatography</i>). </p><p>Le principe de cette méthode est le suivant : par <a href="/wiki/G%C3%A9nie_g%C3%A9n%C3%A9tique" title="Génie génétique">génie génétique</a>, on ajoute à la protéine une séquence contenant au moins six histidines consécutives (étiquette polyhistidine). Cette étiquette est capable d'interagir fortement avec des ions métalliques. On utilise cette propriété pour fixer la protéine ainsi étiquetée sur une résine chromatographique sur laquelle est <a href="/wiki/Ch%C3%A9lation" title="Chélation">chélaté</a> un ion métallique. Après lavage des protéines non retenues, la protéine est ensuite éluée par une solution d'<a href="/wiki/Imidazole" title="Imidazole">imidazole</a> qui déplace la protéine de l'ion métallique par compétition. </p> <div class="mw-heading mw-heading3"><h3 id="Dérivés_de_l'histidine"><span id="D.C3.A9riv.C3.A9s_de_l.27histidine"></span>Dérivés de l'histidine</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=5" title="Modifier la section : Dérivés de l'histidine" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=5" title="Modifier le code source de la section : Dérivés de l'histidine"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Par méthylation de l'histidine en 1, ou en 3, on obtient des acides aminés méthylés présents dans l'urine de l'homme. Cet acide aminé également est un précurseur de la <a href="/wiki/Biosynth%C3%A8se" title="Biosynthèse">biosynthèse</a> de l'<a href="/wiki/Histamine" title="Histamine">histamine</a> (<a href="/wiki/Vasodilatateur" title="Vasodilatateur">vasodilatateur</a>) et de la <a href="/wiki/Carnosine" title="Carnosine">carnosine</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Présence_dans_le_corps_humain"><span id="Pr.C3.A9sence_dans_le_corps_humain"></span>Présence dans le corps humain</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=6" title="Modifier la section : Présence dans le corps humain" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=6" title="Modifier le code source de la section : Présence dans le corps humain"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>En mesure BDC (<i><a href="/wiki/Binary_coded_decimal" class="mw-redirect" title="Binary coded decimal">Binary coded decimal</a></i> ) un taux normal d'Histidine dans le corps est compris entre 391 et 547 selon la méthode turbidimétrique réalisée sur Olympus AU640<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite_crochet">[</span>8<span class="cite_crochet">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Propriétés_chimiques_et_physiques"><span id="Propri.C3.A9t.C3.A9s_chimiques_et_physiques"></span>Propriétés chimiques et physiques</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=7" title="Modifier la section : Propriétés chimiques et physiques" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=7" title="Modifier le code source de la section : Propriétés chimiques et physiques"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>En utilisant le sel d'histidine comme exemple, une interaction <a href="/wiki/Anion" title="Anion">anion</a>-anion du type anion carboxylate-tétroxyde a été découverte pour la première fois<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite_crochet">[</span>9<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=8" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=8" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references-small decimal" style="column-width:30em;"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink noprint"><a href="#cite_ref-1">↑</a> </span><span class="reference-text">Masse molaire calculée d’après <span class="ouvrage">« <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iupac/AtWt/"><cite style="font-style:normal;"><span class="lang-en" lang="en">Atomic weights of the elements 2007</span></cite></a> », sur <span class="italique">www.chem.qmul.ac.uk</span></span>.</span> </li> <li id="cite_note-2"><span class="mw-cite-backlink noprint"><a href="#cite_ref-2">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="Carey2014"><span class="ouvrage" id="Francis_A._Carey2014"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Francis A. Carey, « <a rel="nofollow" class="external text" href="http://www.chem.ucalgary.ca/courses/351/Carey5th/Ch27/ch27-1-4-2.html"><cite style="font-style:normal;" lang="en">Table of pKa and pI values</cite></a> », sur <span class="italique">Département de chimie de l'<a href="/wiki/Universit%C3%A9_de_Calgary" title="Université de Calgary">université de Calgary</a></span>, <time>2014</time> <small style="line-height:1em;">(consulté le <time class="nowrap" datetime="2015-07-26" data-sort-value="2015-07-26">26 juillet 2015</time>)</small></span></span>.</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink noprint"><a href="#cite_ref-3">↑</a> </span><span class="reference-text"> <span class="ouvrage" id="Beals,_L._Gross,_S._Harrell"><span class="ouvrage" id="M._Beals,_L._Gross,_S._Harrell"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> M. Beals, L. Gross, S. Harrell, « <a rel="nofollow" class="external text" href="http://www.tiem.utk.edu/~gross/bioed/webmodules/aminoacid.htm"><cite style="font-style:normal;" lang="en">Amino Acid Frequency</cite></a> », sur <span class="italique">The Institute for Environmental Modeling (TIEM) à l'<a href="/wiki/Universit%C3%A9_du_Tennessee" title="Université du Tennessee">université du Tennessee</a></span> <small style="line-height:1em;">(consulté le <time class="nowrap" datetime="2015-07-26" data-sort-value="2015-07-26">26 juillet 2015</time>)</small></span></span>.</span> </li> <li id="cite_note-Reptox-4"><span class="mw-cite-backlink noprint"><a href="#cite_ref-Reptox_4-0">↑</a> </span><span class="reference-text">« <a rel="nofollow" class="external text" href="http://www.reptox.csst.qc.ca/DetailSimdut.asp?no_produit=46144&langue=F">Histidine (l-)</a> » dans la base de données de produits chimiques <i>Reptox</i> de la <a href="/wiki/Commission_de_la_sant%C3%A9_et_de_la_s%C3%A9curit%C3%A9_du_travail" title="Commission de la santé et de la sécurité du travail">CSST</a> (organisme québécois responsable de la sécurité et de la santé au travail), consulté le 25 avril 2009</span> </li> <li id="cite_note-5"><span class="mw-cite-backlink noprint"><a href="#cite_ref-5">↑</a> </span><span class="reference-text"><a rel="nofollow" class="external text" href="http://home.scarlet.be/tabularium/bailly/441.htm">Abrégé du dictionnaire grec-français</a> A. Bailly, <abbr class="abbr" title="page">p.</abbr> 441.</span> </li> <li id="cite_note-6"><span class="mw-cite-backlink noprint"><a href="#cite_ref-6">↑</a> </span><span class="reference-text"><a rel="nofollow" class="external text" href="http://georges.dolisi.free.fr/Terminologie/H/histo.htm">Terminologie médicale</a>, par Georges Dolisi</span> </li> <li id="cite_note-7"><span class="mw-cite-backlink noprint"><a href="#cite_ref-7">↑</a> </span><span class="reference-text"><span class="ouvrage" id="MoroToméSchmidelyDemersay2020"><span class="ouvrage" id="Joanna_MoroDaniel_ToméPhilippe_SchmidelyTristan-Chalvon_Demersay2020"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Joanna <span class="nom_auteur">Moro</span>, Daniel <span class="nom_auteur">Tomé</span>, Philippe <span class="nom_auteur">Schmidely</span> et Tristan-Chalvon <span class="nom_auteur">Demersay</span>, « <cite style="font-style:normal" lang="en">Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species</cite> », <i><span class="lang-en" lang="en">Nutrients</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 12, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 5,‎ <time class="nowrap" datetime="2020-05-14" data-sort-value="2020-05-14">14 mai 2020</time>, <abbr class="abbr" title="page">p.</abbr> 1414 <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/2072-6643">2072-6643</a></span>, <a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/32423010">32423010</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284872">PMC7284872</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.3390/nu12051414">10.3390/nu12051414</a></span>, <a rel="nofollow" class="external text" href="https://www.mdpi.com/2072-6643/12/5/1414">lire en ligne</a>, consulté le <time class="nowrap" datetime="2022-02-08" data-sort-value="2022-02-08">8 février 2022</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Histidine%3A+A+Systematic+Review+on+Metabolism+and+Physiological+Effects+in+Human+and+Different+Animal+Species&rft.jtitle=Nutrients&rft.issue=5&rft.aulast=Moro&rft.aufirst=Joanna&rft.au=Tom%C3%A9%2C+Daniel&rft.au=Schmidely%2C+Philippe&rft.au=Demersay%2C+Tristan-Chalvon&rft.date=2020-05-14&rft.volume=12&rft.pages=1414&rft.issn=2072-6643&rft_id=info%3Adoi%2F10.3390%2Fnu12051414&rft_id=info%3Apmid%2F32423010&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AHistidine"></span></span></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink noprint"><a href="#cite_ref-8">↑</a> </span><span class="reference-text">laboratoire d'analyses CEIA Bruxelles</span> </li> <li id="cite_note-9"><span class="mw-cite-backlink noprint"><a href="#cite_ref-9">↑</a> </span><span class="reference-text"><span class="ouvrage" id="NovikovSafonovGermanGrigoriev2023"><span class="ouvrage" id="Anton_P._NovikovAlexey_V._SafonovKonstantin_E._GermanMikhail_S._Grigoriev2023"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Anton P. <span class="nom_auteur">Novikov</span>, Alexey V. <span class="nom_auteur">Safonov</span>, Konstantin E. <span class="nom_auteur">German</span> et Mikhail S. <span class="nom_auteur">Grigoriev</span>, « <cite style="font-style:normal" lang="en">What kind of interactions we may get moving from zwitter to “dritter” ions: C–O⋯Re(O4) and Re–O⋯Re(O4) anion⋯anion interactions make structural difference between L-histidinium perrhenate and pertechnetate</cite> », <i><span class="lang-en" lang="en">CrystEngComm</span></i>,‎ <time class="nowrap" datetime="2023-12-01" data-sort-value="2023-12-01"><abbr class="abbr" title="premier">1<sup>er</sup></abbr> décembre 2023</time> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1466-8033">1466-8033</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1039/D3CE01164J">10.1039/D3CE01164J</a></span>, <a rel="nofollow" class="external text" href="https://pubs.rsc.org/en/content/articlelanding/2024/ce/d3ce01164j">lire en ligne</a>, consulté le <time class="nowrap" datetime="2023-12-09" data-sort-value="2023-12-09">9 décembre 2023</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=What+kind+of+interactions+we+may+get+moving+from+zwitter+to+%E2%80%9Cdritter%E2%80%9D+ions%3A+C%E2%80%93O%E2%8B%AFRe%28O4%29+and+Re%E2%80%93O%E2%8B%AFRe%28O4%29+anion%E2%8B%AFanion+interactions+make+structural+difference+between+L-histidinium+perrhenate+and+pertechnetate&rft.jtitle=CrystEngComm&rft.aulast=Novikov&rft.aufirst=Anton+P.&rft.au=Safonov%2C+Alexey+V.&rft.au=German%2C+Konstantin+E.&rft.au=Grigoriev%2C+Mikhail+S.&rft.date=2023-12-01&rft.issn=1466-8033&rft_id=info%3Adoi%2F10.1039%2FD3CE01164J&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AHistidine"></span></span></span></span> </li> </ol> </div> <div class="mw-heading mw-heading2"><h2 id="Liens_externes">Liens externes</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Histidine&veaction=edit&section=9" title="Modifier la section : Liens externes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Histidine&action=edit&section=9" title="Modifier le code source de la section : Liens externes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/His1.html">Histidine biosynthesis (early stages)</a></li> <li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/His2.html">Histidine biosynthesis (later stages)</a></li> <li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a rel="nofollow" class="external text" href="http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/AminoAcid/His3.html">Histidine catabolism</a></li> <li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a rel="nofollow" class="external text" href="http://www.compchemwiki.org/index.php?title=Histidine">Computational Chemistry Wiki</a></li> <li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> <a rel="nofollow" class="external free" href="http://www.chemie.fu-berlin.de/chemistry/bio/aminoacid/histidin_en.html">http://www.chemie.fu-berlin.de/chemistry/bio/aminoacid/histidin_en.html</a></li></ul> <div class="navbox-container" style="clear:both;"> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="3" style=""><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_Acides_amin%C3%A9s" title="Modèle:Palette Acides aminés"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_Acides_amin%C3%A9s&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%"><a href="/wiki/Acide_amin%C3%A9" title="Acide aminé">Acides aminés</a></div></th> </tr> <tr> <th class="navbox-group" style="width:200px;"><a href="/wiki/Acide_amin%C3%A9_prot%C3%A9inog%C3%A8ne" title="Acide aminé protéinogène">Acide aminé protéinogène</a></th> <td class="navbox-list" style=""><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style=""><a href="/wiki/Compos%C3%A9_aliphatique" title="Composé aliphatique">Aliphatique</a></th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Acide_amin%C3%A9_ramifi%C3%A9" title="Acide aminé ramifié">Acide aminé ramifié</a> <ul><li><a href="/wiki/Valine" title="Valine">Valine</a></li> <li><a href="/wiki/Isoleucine" title="Isoleucine">Isoleucine</a></li> <li><a href="/wiki/Leucine" title="Leucine">Leucine</a></li></ul></li> <li><a href="/wiki/M%C3%A9thionine" title="Méthionine">Méthionine</a></li> <li><a href="/wiki/Alanine" title="Alanine">Alanine</a></li> <li><a href="/wiki/Proline" title="Proline">Proline</a></li> <li><a href="/wiki/Glycine_(acide_amin%C3%A9)" title="Glycine (acide aminé)">Glycine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Acide_amin%C3%A9#Acides_aminés_aromatiques" title="Acide aminé">Aromatique</a></th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Ph%C3%A9nylalanine" title="Phénylalanine">Phénylalanine</a></li> <li><a href="/wiki/Tyrosine" title="Tyrosine">Tyrosine</a></li> <li><a href="/wiki/Tryptophane" title="Tryptophane">Tryptophane</a></li> <li><a class="mw-selflink selflink">Histidine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Polarit%C3%A9_(chimie)" title="Polarité (chimie)">Polaire</a>, non chargé</th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Asparagine" title="Asparagine">Asparagine</a></li> <li><a href="/wiki/Glutamine" title="Glutamine">Glutamine</a></li> <li><a href="/wiki/S%C3%A9rine" title="Sérine">Sérine</a></li> <li><a href="/wiki/Thr%C3%A9onine" title="Thréonine">Thréonine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Charge positive (<a href="/wiki/Constante_d%27acidit%C3%A9" title="Constante d'acidité">p<i>K</i><sub>a</sub></a>)</th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Lysine" title="Lysine">Lysine</a> (≈10,8)</li> <li><a href="/wiki/Arginine" title="Arginine">Arginine</a> (≈12,5)</li> <li><a class="mw-selflink selflink">Histidine</a> (≈6.1)</li> <li><a href="/wiki/Pyrrolysine" title="Pyrrolysine">Pyrrolysine</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Charge négative (<a href="/wiki/Constante_d%27acidit%C3%A9" title="Constante d'acidité">p<i>K</i><sub>a</sub></a>)</th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/Acide_aspartique" title="Acide aspartique">Aspartate</a> (≈3,9)</li> <li><a href="/wiki/Acide_glutamique" title="Acide glutamique">Glutamate</a> (≈4,1)</li> <li><a href="/wiki/S%C3%A9l%C3%A9nocyst%C3%A9ine" title="Sélénocystéine">Sélénocystéine</a> (≈5,4)</li> <li><a href="/wiki/Cyst%C3%A9ine" title="Cystéine">Cystéine</a> (≈8,3)</li> <li><a href="/wiki/Tyrosine" title="Tyrosine">Tyrosine</a> (≈10,1)</li></ul> </div></td> </tr> </tbody></table></td> <td class="navbox-image" rowspan="2" style="vertical-align:middle;padding-left:7px"><figure class="mw-halign-right" typeof="mw:File"><a href="/wiki/Fichier:L-amino_acid_any.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/L-amino_acid_any.png/145px-L-amino_acid_any.png" decoding="async" width="145" height="127" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/L-amino_acid_any.png/218px-L-amino_acid_any.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/L-amino_acid_any.png/290px-L-amino_acid_any.png 2x" data-file-width="728" data-file-height="640" /></a><figcaption></figcaption></figure></td> </tr> <tr> <th class="navbox-group" style="width:200px;"><a href="/wiki/Acide_amin%C3%A9_non_prot%C3%A9inog%C3%A8ne" title="Acide aminé non protéinogène">Acide aminé non protéinogène</a></th> <td class="navbox-list navbox-even" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Acide_amin%C3%A9_non_prot%C3%A9inog%C3%A8ne#Acides_aminés_non_protéinogènes_présents_dans_des_protéines" title="Acide aminé non protéinogène">Acides aminés non protéinogènes présents dans des protéines</a></li> <li><a href="/wiki/Acide_amin%C3%A9_non_prot%C3%A9inog%C3%A8ne#Autres_acides_aminés_non_protéinogènes" title="Acide aminé non protéinogène">Autres acides aminés non protéinogènes</a></li></ul> </div></td> </tr> <tr> <td class="navbox-banner" style="" colspan="3"><div class="liste-horizontale"> <ul><li><a href="/wiki/Prot%C3%A9ine" title="Protéine">Protéine</a></li> <li><a href="/wiki/Peptide" title="Peptide">Peptide</a></li> <li><a href="/wiki/Code_g%C3%A9n%C3%A9tique" title="Code génétique">Code génétique</a></li> <li><a href="/wiki/Acide_amin%C3%A9_essentiel" title="Acide aminé essentiel">Acide aminé essentiel</a></li> <li><a href="/wiki/Acide_amin%C3%A9_glucoformateur" title="Acide aminé glucoformateur">Acide aminé glucoformateur</a></li> <li><a href="/wiki/Acide_amin%C3%A9_c%C3%A9toformateur" title="Acide aminé cétoformateur">Acide aminé cétoformateur</a></li> <li><a href="/wiki/Acide_amin%C3%A9#Acides_aminés_non_standard" title="Acide aminé">Acide aminé non standard</a></li></ul> </div></td></tr></tbody></table> </div> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span 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