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Thank you!","agentName":"SBS Genetech","agentTitle":"","agentProfilePictureUrl":"\/\/custom-images.strikinglycdn.com\/res\/hrscywv4p\/image\/upload\/c_limit,fl_lossy,h_200,w_200,f_auto,q_auto\/2311560\/61544_357646.jpeg","enableDesktopNotifications":null,"colorTheme":"#1a468d","autoPopup":10,"hasUploadAvatar":true,"emailOption":0,"showStrikinglyLogo":false,"requiredFields":["email"],"enableGoogleAdsConversionTracking":null,"googleAdsConversionName":"submit_lead_form","enableRecaptcha":false,"blockDisposableEmails":false},"showNav":null,"hideNewBlogTips":true,"connectedSites":[{"label":"English","siteId":13239339,"countryCode":"en","publicUrl":"https:\/\/www.sbsgenetech.com\/"},{"label":"\u7b80\u4f53\u4e2d\u6587","siteId":13243898,"countryCode":"zh-CN","publicUrl":"https:\/\/www.sbsgenetech.cn\/"}]},"content":{"type":"Blog.BlogData","id":"f_ca83cf09-4255-4bbe-b14c-8b2b37e3c992","showComments":true,"header":{"type":"Blog.Header","id":"f_6b78f948-ff44-440b-8dba-c180a8433457","title":{"type":"Blog.Text","id":"f_dd2744fd-ba3e-4077-b600-8da03b14c69c","defaultValue":false,"value":"\u003cdiv class=\"s-rich-text-wrapper\" style=\"display: block;\"\u003e\u003cp class=\"s-rich-text-wrapper s-rich-text-wrapper\"\u003e\u003cstrong\u003eCongratulations to Our Customer for Published in Bioactive Materials (IF: 18)!\u003c\/strong\u003e\u003c\/p\u003e\u003c\/div\u003e","version":1},"subTitle":{"type":"Blog.Text","id":"f_6985a157-f822-4cb1-b4e8-7fe9ef75b24d","defaultValue":false,"value":"\u003cdiv class=\"s-rich-text-wrapper\" style=\"display: block;\"\u003e\u003cp class=\"s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper\" style=\"font-size: 80%;\"\u003eThis study presents a nanoengineered peptide PROTACs (NP-PROTACs) strategy that simultaneously degrades \u03b2-catenin and STAT3 to inhibit colorectal cancer growth and improve the immune microenvironment.\u003c\/p\u003e\u003c\/div\u003e","version":1},"backgroundImage":{"type":"Blog.BackgroundImage","id":"f_5e2d2b91-318c-42f1-ade5-e3397ddd8756","defaultValue":false,"url":"!","textColor":"overlay","sizing":"cover","userClassName":"","videoHtml":"","storageKey":"2311560\/776368_807265","storage":"s","format":"png","h":1024,"w":1024,"s":2260907,"useImage":true,"focus":null}},"footer":{"type":"Blog.Footer","id":"f_8e3f3e0f-a257-4cc8-bb58-bda98801dca8","comment":{"type":"Blog.Comment","id":"f_ce9e1546-8c3b-4e14-b44e-4343f7fc7d6f","shortName":""},"shareButtons":{"type":"Blog.ShareButtons","id":"f_e59c607e-5467-4460-817d-bfafefad34e6","defaultValue":false,"list_type":"link","button_list":[{"type":"Facebook","id":"f_62332d45-fb6a-4f25-9e16-d3bf86e7851a","url":"","show_button":true},{"type":"LinkedIn","id":"f_87fec1ca-d308-42fd-9e61-823638e6668b","url":"","show_button":true},{"type":"Twitter","id":"f_5c4a0a2a-daa5-4b96-8751-c5dd39bd9039","url":"","show_button":true},{"type":"Pinterest","id":"f_9afa1287-dc55-46a9-8c4b-571b3fc56853","url":"","show_button":false}]}},"sections":[{"type":"Blog.Section","id":"19dd2a56-a168-4a15-be0c-bc99e3f6a673","defaultValue":null,"component":{"type":"RichText","id":"52c26665-f9b2-4dc0-850c-aa3ddc406161","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003eOn Sep 25th, research team from Fudan University published a groundbreaking research paper titled \"Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy\" in the journal \"Bioactive Materials\" \u003cspan style=\"color: #444444;\"\u003e(impact factor: 18.0).\u003c\/span\u003e\u0026nbsp;\u003c\/p\u003e","backupValue":null,"version":1,"wrapperClass":"s-narrow-margin"}},{"type":"Blog.Section","id":"19dd2a56-a168-4a15-be0c-bc99e3f6a673","defaultValue":null,"component":{"type":"RichText","id":"a9c3fb18-b0c2-4a12-ab52-5219c9a5be4a","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003eIn colorectal cancer (CRC) research, \u03b2-catenin and STAT3 have been identified as key drivers of cancer growth, progression, and immune evasion. Their co-overexpression is strongly associated with poor prognosis in patients. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and \u03b2-catenin.\u003c\/p\u003e","backupValue":null,"version":1,"wrapperClass":"s-narrow-margin"}},{"type":"Blog.Section","id":"df80ebc8-cd6b-4a51-8f8a-3534bf63e77a","defaultValue":null,"component":{"type":"RichText","id":"012bc8bf-9e95-4cb6-a7a8-dd0e15aca5bc","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003eInspired by the PROteolysis TArgeting Chimera (PROTAC), researchers have developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to simultaneously degrade \u03b2-catenin and STAT3. This novel treatment method involves coupling peptide PROTACs with DSPE-PEG via disulfide bonds and self-assembling into nanoparticles, thereby achieving effective degradation of both proteins.\u003c\/p\u003e","backupValue":null,"version":1,"wrapperClass":"s-narrow-margin"}},{"type":"Blog.Section","id":"69220403-ad2c-4324-8ed1-ec4abe5f0385","defaultValue":null,"component":{"type":"RichText","id":"23837717-eaac-4d2d-bac3-ffd630cd33c9","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003eStudies have shown that the dual degradation of \u03b2-catenin and STAT3 mediated by NP-PROTACs exhibits a stronger synergistic antitumor effect compared to single-target treatments. This dual-target approach not only inhibits cancer cell growth and progression but also significantly enhances the infiltration of CD103+ dendritic cells and the cytotoxicity of T cells, alleviating the immunosuppressive microenvironment induced by \u03b2-catenin\/STAT3 in CRC.\u003c\/p\u003e","backupValue":null,"version":1,"wrapperClass":"s-narrow-margin"}},{"type":"Blog.Section","id":"19dd2a56-a168-4a15-be0c-bc99e3f6a673","defaultValue":null,"component":{"type":"RichText","id":"0833796a-4078-4f74-94b0-e8786c94d1ef","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003eThe successful application of NP-PROTACs offers a new avenue for cancer therapy. By simultaneously degrading two pathogenic proteins, this strategy has the potential to overcome the limitations of current treatments and provide more effective therapeutic outcomes. As research progresses, NP-PROTACs are expected to become a new hope for the treatment of colorectal cancer and other types of cancer.\u003c\/p\u003e","backupValue":null,"version":1,"wrapperClass":"s-narrow-margin"}},{"type":"Blog.Section","id":"409355d3-f5cb-4a7f-a23e-266f39d5d197","defaultValue":null,"component":{"type":"RichText","id":"c6f55a2f-cd0c-48ee-89e0-56ebadebf5fa","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"display: inline-block\"\u003e\u0026nbsp;\u003c\/span\u003e\u003c\/p\u003e","backupValue":null,"version":1,"wrapperClass":"s-narrow-margin"}},{"type":"Blog.Section","id":"2012493e-5342-43e5-8d88-5f681685e701","defaultValue":null,"component":{"type":"Image","id":"efdd4f57-f5fc-449d-b285-b168d4121aab","defaultValue":null,"link_url":"","thumb_url":"!","url":"!","caption":"","description":"","storageKey":"2311560\/975597_3938","storage":"s","storagePrefix":null,"format":"png","h":1196,"w":1472,"s":518647,"new_target":true,"focus":null}},{"type":"Blog.Section","id":"409355d3-f5cb-4a7f-a23e-266f39d5d197","defaultValue":null,"component":{"type":"RichText","id":"76f51cd5-d2d0-47cf-8ce1-0ae83b11ae22","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"display: inline-block\"\u003e\u0026nbsp;\u003c\/span\u003e\u003c\/p\u003e","backupValue":null,"version":1,"wrapperClass":"s-narrow-margin"}},{"type":"Blog.Section","id":"409355d3-f5cb-4a7f-a23e-266f39d5d197","defaultValue":null,"component":{"type":"RichText","id":"0ce1e6e8-72e2-4510-821d-d18ed7341b28","defaultValue":false,"value":"\u003cp style=\"text-align: justify;\"\u003eIn conjunction with the research study, the DNA transfection reagent is supplied by SBS Genetech. Since 2000, \u003ca href=\"https:\/\/www.sbsgenetech.com\/\" data-type=\"undefined\" target=\"_blank\"\u003eSBS Genetech\u003c\/a\u003e has been at the forefront of providing solutions in life sciences. We offer safer, superior quality, and more cost-effective products to preeminent researchers in more than 60 countries, empowering them to make new discoveries in biology. Our products have been widely utilized in academic research, with results often published in leading academic journals like \u003cem\u003eScience\u003c\/em\u003e, \u003cem\u003eCell\u003c\/em\u003e, \u003cem\u003eCancer Cell\u003c\/em\u003e, and \u003cem\u003eCell Metabolism\u003c\/em\u003e. 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At our core, we specialize in standard oligo synthesis, delivering reliable and high-quality DNA sequences. But that's not all. We go above and beyond to meet your diverse research needs. Our scientific research services extend to long oligo synthesis, phosphorothioate oligo (S-Oligo) synthesis, modified oligo synthesis, fluorescent oligo synthesis, and real-time quantitative PCR probes. Furthermore, our commitment to excellence extends to the provision of top-tier DNA synthesis products. From phosphoramidites to controlled pore glass and molecular sieves, our range of high-quality products has successfully empowered researchers across various molecular biology fields. 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At our core, we prioritize quality and reliability. Each of our peptides is accompanied by robust HPLC and mass spectrometry data, ensuring the utmost confidence in their purity and integrity. Our detailed synthesis reports provide comprehensive information, and the peptides are conveniently delivered in a lyophilized state for ease of use. With our experienced team of professionals, we offer more than just synthesis services. We are here to assist you in designing peptide chains and provide tailored recommendations to meet your specific needs. 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Within our comprehensive product portfolio, you will find Synthesis Columns for ABI 3900, MerMade, Dr. Oligos, OligoMaker, ASM-2000, and more. We also provide Universal Support-CPG, Standard Support-CPG, DNA Phosphoramidites, LNA Phosphoramidites, Modified Amidites \u0026amp; CPG, Molecular Sieves, and other essential components for DNA synthesis. Whether you are performing routine DNA synthesis or exploring cutting-edge research, our products are designed to meet your specific needs. 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At the heart of our platform lies our Bst DNA\/RNA Polymerase, a powerful combination of Bst polymerase and exceptionally thermostable reverse transcriptase. This unique enzyme serves as the foundation for our PrimeIamp\u003csup\u003eTM\u003c\/sup\u003e series. These ready-to-use master mixes have been meticulously developed to streamline your workflow, allowing for direct isothermal amplification upon addition of templates and primers. Besides, as part of our commitment to continuous improvement, we now introduce the Bst P DNA\/RNA Polymerase, an upgraded version of our Bst DNA\/RNA Polymerase. This enhanced enzyme further elevates the performance and reliability of our isothermal amplification solutions. Furthermore, with our innovative freeze-drying technology, these master mixes are transformed into solid microbeads, ensuring convenient transport and storage at room temperature. 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It emits green fluorescence when bound to DNA or RNA. This new stain has two fluorescence excitation maxima when bound to nucleic acid, one centered at 268 nm and the other at 294 nm. In addition, it has one visible excitation at 491 nm. The Fluorescence emission of GoodView bound to DNA is centered at 530 nm.\u003c\/span\u003e Our GoodView\u2122 Nucleic Acid Stain has been featured in the esteemed New Products section of the renowned Science Journal (January 11, 2019 edition). 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At our disposal, we offer a diverse selection of DNA polymerases, including Taq, Bst, and Pfu, each tailored to meet your specific needs. Our PCR premixes are designed to deliver exceptional performance, whether you require high fidelity, high specificity, or rapid amplification. To ensure reliable and accurate results, we also provide high-quality dNTPs and NTPs in convenient sets or mixes. These essential components guarantee optimal PCR performance, allowing you to focus on your research without compromise. 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While DNA and RNA share a common nucleotide chain assembly, RNA distinguishes itself by existing as single-stranded folds, setting it apart from its double-stranded DNA counterpart. At our core, we offer a complete solution for RNA research. Our high-quality NTPs, RNasin (RNase inhibitor), and M-MLV reverse transcriptase form the backbone of your RNA studies, ensuring reliable and accurate results. From transcription to reverse transcription, we have you covered. For the isolation of viral RNA\/DNA or bacterial DNA, our VirusMag\u2122 series provides optimized solutions that guarantee efficiency and accuracy. Streamline your workflows and extract valuable genetic material effortlessly. 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Our products include affinity gels, magnetic beads, gel filtration media, and inhibitors. Affinity gels and magnetic beads are used for capturing and purifying target proteins. Our protein purification media have high binding capacity and can efficiently purify specific proteins. Additionally, we provide various protease inhibitors to protect proteins from degradation. We also offer assay kits and labeling reagents for protein quantification and analysis. These products assist scientists in studying and understanding protein function and interactions. 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Peptides are short-chain proteins composed of amino acids and possess diverse biological activities and functions. Among them, Amyloid \u03b2 Peptide is an important protein associated with neurodegenerative diseases like Alzheimer's disease. We provide Amyloid \u03b2 Peptides in different lengths and variants to facilitate in-depth research on their roles. Additionally, we offer other peptide products such as Oxytocin, Somatostatin, Thyrotropin-Releasing Hormone (TRH), Desmopressin, and more. These peptides play crucial roles in regulating physiological functions, neuroregulation, and growth control, making them ideal tools for research. Our peptide products undergo rigorous quality control and validation to ensure their purity and activity. 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Whether you are involved in cell culture, cell separation, cell analysis, or cell detection, our product line is designed to meet your requirements. Our product line includes MycoErase\u2122 for removing mycoplasma, efficient TurboTryp\u2122 enzymes, peripheral blood lymphocyte separation kits (for rabbits, mice, rats, and humans), apoptosis detection kits, luciferase reporter gene analysis kits, cell viability assay kits, and cell counting kits. By choosing our cell-related product line, you will gain access to exceptional quality and reliable performance, empowering you to make breakthroughs in your cell research. 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The success of any RNA experiment depends on high-quality siRNA and effective transfection reagent. With chemical modification, our \u003ca target=\"_blank\" href=\"https:\/\/www.sbsgenetech.com\/store\/products\/chemically-modified-sirna\"\u003echemically modified siRNA\u003c\/a\u003e has much higher stability than the common siRNA. The chemical modification not only enhances the life span of siRNA in serum and cell culture but also enhances its activity \u003cem\u003ein vitro\u003c\/em\u003e. As for transfection reagent, our ready-to-use siRNA transfection reagent, \u003ca target=\"_blank\" href=\"https:\/\/www.sbsgenetech.com\/store\/products\/sirnafectamine-transfection-reagent\"\u003eSirnafectamine\u003c\/a\u003e, can be used for a wide range of cell lines, with minimal cytotoxicity and the best cell state after transfection. As Sirnafectamine will protect RNA during the whole process, a very low concentration of siRNA can produce high gene silencing efficiency.\u003c\/p\u003e","backupValue":null,"version":1}}},{"type":"RepeatableItem","id":"f_4a5f3aea-3f36-41a9-a82f-09848101a6b8","defaultValue":null,"components":{"button1":{"type":"Button","id":"f_e1bc2abe-ab2a-4b11-a6e0-a9ce2cb68357","defaultValue":true,"text":"","link_type":null,"page_id":null,"section_id":null,"url":"","new_target":null},"media1":{"type":"Media","id":"f_58605c02-15c6-48c1-837d-3ca0c408694f","defaultValue":true,"video":{"type":"Video","id":"f_799f0719-2298-4d56-9378-6f6e27cba04f","defaultValue":true,"html":"","url":"https:\/\/vimeo.com\/18150336","thumbnail_url":null,"maxwidth":700,"description":null},"image":{"type":"Image","id":"f_451564ba-42c5-4a89-8c99-89683543ba91","defaultValue":true,"link_url":"https:\/\/www.sbsgenetech.com\/nucleic-acid-purification","thumb_url":"!","url":"!","caption":"Nucleic Acid Purification\u200b - SBS Genetech","description":"","storageKey":"2311560\/365481_960148","storage":"s","storagePrefix":null,"format":"png","h":686,"w":716,"s":374662,"new_target":true,"noCompression":null,"cropMode":null,"focus":null},"current":"image"},"text1":{"type":"RichText","id":"f_ac67cd3d-ac17-496f-afdb-4b267c972cfe","defaultValue":false,"value":"\u003cdiv class=\"s-rich-text-wrapper\" style=\"display: block;\"\u003e\u003ch3 class=\"s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-rich-text-wrapper\" style=\"font-size: 24px;\"\u003e\u003cspan style=\"color: #1a478e;\"\u003e\u003ca style=\"color: #1a478e;\" href=\"https:\/\/www.sbsgenetech.com\/nucleic-acid-purification\" data-type=\"\" target=\"_blank\"\u003e\u003cstrong\u003eNucleic Acid Purification\u200b\u003c\/strong\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/h3\u003e\u003c\/div\u003e","backupValue":null,"version":1},"text2":{"type":"RichText","id":"f_634f5fca-88c1-473e-bcfe-373bc32fcbce","defaultValue":false,"value":"","backupValue":null,"version":1},"text3":{"type":"RichText","id":"f_6efa2ad3-adb6-4119-b19c-08f06a14b4f4","defaultValue":false,"value":"\u003cp style=\"font-size: 100%; text-align: justify;\"\u003eNucleic acid purification is an important component of molecular biology and has a wide range of applications in medicine and biological sciences. Our nucleic acid purification kit uses first-class silica gel column technology (\u003ca target=\"_blank\" href=\"https:\/\/www.sbsgenetech.com\/store\/products\/397711\"\u003eSiMax\u2122 Spin Column\u003c\/a\u003e) and magnetic beads technology (\u003ca target=\"_blank\" href=\"https:\/\/www.sbsgenetech.com\/store\/products\/454659\"\u003eVSep\u2122 Magnetic Separators\u003c\/a\u003e, \u003ca target=\"_blank\" href=\"https:\/\/www.sbsgenetech.com\/store\/products\/419414\"\u003eVirusMag\u2122 One-Step DNA\/RNA Isolation Kit\u003c\/a\u003e, \u003ca target=\"_blank\" href=\"https:\/\/www.sbsgenetech.com\/store\/products\/412721\"\u003eVirusMag\u2122 DNA\/RNA Isolation Kit\u003c\/a\u003e), which can purify DNA\/RNA from various sources quickly and reliably. 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At the forefront of this innovation, we proudly offer a diverse range of high-quality microspheres that exhibit batch-to-batch consistency, laying a solid foundation for large-scale production. Our extensive product portfolio includes magnetic microspheres, latex microspheres, dyed microspheres, fluorescent microspheres, flow cytometry microspheres, and standard microspheres. 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We offer a wide range of molecular weight standards for different fragment lengths. Our markers undergo separate purification, surpassing industry standards, ensuring exceptional quality. With our markers, you can confidently achieve accurate and reliable gel electrophoresis results. 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The gene-editing technology based on this system has a wide variety of applications. Here, we provide various \u003ca href=\"http:\/\/www.sbsgenetech.com\/crispr-gene-editing\" data-type=\"\" target=\"_blank\"\u003eCas nucleases\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/portfolio\/items\/synthetic-sgrnas\" data-type=\"\" target=\"_blank\"\u003esynthetic sgRNAs\u003c\/a\u003e, and \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/t7-endonuclease-i\" data-type=\"\" target=\"_blank\"\u003eT7 Endonuclease I\u003c\/a\u003e of high quality to improve the accuracy and efficiency of your experiments. We also offer t\u003cspan style=\"color: #50555c;\"\u003ehe \u003c\/span\u003e\u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/cas13a-nuclease-lyophilized\" data-type=\"web\" target=\"_blank\"\u003eCas13a Nuclease (Lyophilized)\u003c\/a\u003e\u003cspan style=\"color: #50555c;\"\u003e and \u003c\/span\u003e\u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/cas12a-nuclease-lyophilized\" data-type=\"web\" target=\"_blank\"\u003eCas12a Nuclease (Lyophilized)\u003c\/a\u003e that \u003cspan style=\"color: #50555c;\"\u003ecan be transported at room temperature, saving the high cost of dry ice transportation. \u003c\/span\u003eBy choosing our high-quality CRISPR products, you gain access to exceptional gene editing tools that empower you to conduct cutting-edge genetic research and biotechnological applications. We are dedicated to providing you with premium products and professional technical support to drive breakthroughs in scientific research.\u003c\/p\u003e\u003c\/div\u003e","backupValue":null,"version":1}}},{"type":"RepeatableItem","id":"f_e7d848af-6e66-4463-a846-f78e90c9332a","defaultValue":null,"components":{"button1":{"type":"Button","id":"f_e885f283-2d91-48da-9286-d66020e69845","defaultValue":true,"text":"","link_type":null,"page_id":null,"section_id":null,"url":"","new_target":null},"media1":{"type":"Media","id":"f_d7ab5495-9daf-4f9a-9b23-56795f6c46c2","defaultValue":true,"video":{"type":"Video","id":"f_799f0719-2298-4d56-9378-6f6e27cba04f","defaultValue":true,"html":"","url":"https:\/\/vimeo.com\/18150336","thumbnail_url":null,"maxwidth":700,"description":null},"image":{"type":"Image","id":"f_451564ba-42c5-4a89-8c99-89683543ba91","defaultValue":true,"link_url":"https:\/\/www.sbsgenetech.com\/biochemicals","thumb_url":"!","url":"!","caption":"Biochemicals\u200b - SBS Genetech","description":"","storageKey":"2311560\/200875_206429","storage":"s","storagePrefix":null,"format":"png","h":686,"w":718,"s":415168,"new_target":true,"noCompression":null,"cropMode":null,"focus":null},"current":"image"},"text1":{"type":"RichText","id":"f_44df6325-85f7-4c28-a667-e166f94b710b","defaultValue":false,"value":"\u003cdiv class=\"s-rich-text-wrapper\" style=\"display: block;\"\u003e\u003ch3 class=\"s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper\" style=\"font-size: 24px;\"\u003e\u003cspan style=\"color: #1a478e;\"\u003e\u003ca style=\"color: #1a478e;\" href=\"https:\/\/www.sbsgenetech.com\/biochemicals\" data-type=\"\" target=\"_blank\"\u003e\u003cstrong\u003eBiochemicals\u200b\u003c\/strong\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/h3\u003e\u003c\/div\u003e","backupValue":null,"version":1},"text2":{"type":"RichText","id":"f_87471581-164e-4243-a771-942056badd7a","defaultValue":false,"value":"","backupValue":null,"version":1},"text3":{"type":"RichText","id":"f_970e0955-3510-4d06-afdc-1a3da9d30f89","defaultValue":false,"value":"\u003cdiv class=\"s-rich-text-wrapper\" style=\"display: block;\"\u003e\u003cp class=\"s-rich-text-wrapper s-rich-text-wrapper\" style=\"text-align: justify; font-size: 100%;\"\u003eBiochemistry, the fascinating field that unravels the chemical processes within living organisms, holds the key to understanding the intricacies of life itself. At our disposal, we proudly offer an extensive range of exceptional biochemical reagents designed to support your research endeavors. Our selection includes remarkable products like\u0026nbsp;\u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/458004\" data-type=\"\" target=\"_blank\"\u003eProteinase K\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/398887\" data-type=\"\" target=\"_blank\"\u003eMutant Proteinase K\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/398886\" data-type=\"\" target=\"_blank\"\u003eBesta\u2122 LE Agarose\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/398893\" data-type=\"\" target=\"_blank\"\u003eIPTG\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/398896\" data-type=\"\" target=\"_blank\"\u003eX-Gal\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/481322\" data-type=\"\" target=\"_blank\"\u003eDNase I (RNase Free)\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/497126\" data-type=\"\" target=\"_blank\"\u003eEnterokinase\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/497194\" data-type=\"\" target=\"_blank\"\u003eSUMO Protease\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/497196\" data-type=\"\" target=\"_blank\"\u003eTEV Protease\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/497205\" data-type=\"\" target=\"_blank\"\u003ePreScission Protease (PSP)\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/552941\" data-type=\"\" target=\"_blank\"\u003eBovine Serum Albumin\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/497107\" data-type=\"\" target=\"_blank\"\u003eT4 DNA Ligase\u003c\/a\u003e, , and many more. Each of these reagents has been meticulously crafted to deliver exceptional performance, reliability, and reproducibility.\u003c\/p\u003e\u003c\/div\u003e","backupValue":null,"version":1}}},{"type":"RepeatableItem","id":"f_61738af2-7239-4af9-9e50-bcb973011d43","defaultValue":null,"components":{"button1":{"type":"Button","id":"f_e544abff-d9c3-4178-acdb-dc4d7235e8c9","defaultValue":true,"text":"","link_type":null,"page_id":null,"section_id":null,"url":"","new_target":null},"media1":{"type":"Media","id":"f_8a81373d-17a0-486e-85cc-9cbf03af7168","defaultValue":true,"video":{"type":"Video","id":"f_799f0719-2298-4d56-9378-6f6e27cba04f","defaultValue":true,"html":"","url":"https:\/\/vimeo.com\/18150336","thumbnail_url":null,"maxwidth":700,"description":null},"image":{"type":"Image","id":"f_451564ba-42c5-4a89-8c99-89683543ba91","defaultValue":true,"link_url":"https:\/\/www.sbsgenetech.com\/nuclease","thumb_url":"!","url":"!","caption":"Nuclease - SBS Genetech","description":"","storageKey":"2311560\/425007_55539","storage":"s","storagePrefix":null,"format":"png","h":685,"w":718,"s":417795,"new_target":true,"noCompression":null,"cropMode":null,"focus":null},"current":"image"},"text1":{"type":"RichText","id":"f_55e17a34-6a79-4482-8e05-f6a5cf6ddda6","defaultValue":false,"value":"\u003cdiv class=\"s-rich-text-wrapper\" style=\"display: block;\"\u003e\u003ch3 class=\"s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-text-color-custom1 s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper\" style=\"font-size: 24px;\"\u003e\u003cspan style=\"color: #1a478e;\"\u003e\u003ca style=\"color: #1a478e;\" href=\"https:\/\/www.sbsgenetech.com\/nuclease\" data-type=\"\" target=\"_blank\"\u003e\u003cstrong\u003eNuclease\u003c\/strong\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/h3\u003e\u003c\/div\u003e","backupValue":null,"version":1},"text2":{"type":"RichText","id":"f_d7119bee-b542-4a4f-ab6e-76b76744a231","defaultValue":false,"value":"","backupValue":null,"version":1},"text3":{"type":"RichText","id":"f_df269feb-02c3-45a1-8e31-1ec025b3de8d","defaultValue":false,"value":"\u003cdiv class=\"s-rich-text-wrapper\" style=\"display: block;\"\u003e\u003cp class=\"s-rich-text-wrapper\" style=\"text-align: justify;\"\u003eNucleases are powerful enzymes that can precisely cleave the phosphodiester bonds within nucleic acids. They have the ability to induce both single- and double-stranded breaks in their target molecules. At our disposal, we proudly offer an array of exceptional nucleases to cater to your research needs. Among our remarkable selection, you will find renowned nucleases such as \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511753\" data-type=\"\" target=\"_blank\"\u003eRNase A\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/412371\" data-type=\"\" target=\"_blank\"\u003eRNase H\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511760\" data-type=\"\" target=\"_blank\"\u003eThermostable RNase H\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511639\" data-type=\"\" target=\"_blank\"\u003eBenzonase Nuclease\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511661\" data-type=\"\" target=\"_blank\"\u003eUracil N-Glycosylase\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511728\" data-type=\"\" target=\"_blank\"\u003eT7 Endonuclease I\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511740\" data-type=\"\" target=\"_blank\"\u003eT5 Exonuclease\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511776\" data-type=\"\" target=\"_blank\"\u003eShrimp Alkaline Phosphatase\u003c\/a\u003e, \u003ca href=\"https:\/\/www.sbsgenetech.com\/store\/products\/511805\" data-type=\"\" target=\"_blank\"\u003eTerminal Transferase\u003c\/a\u003e, , and more. 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Proteases are enzymes that catalyze the hydrolysis of proteins and find extensive applications in various fields, including biochemistry, molecular biology, and biopharmaceuticals. Our protease series encompasses a variety of types and variants, including Recombinant Aprotinin, Recombinant Kex2 Protease, Sequencing Grade Recombinant Carboxypeptidase B, Sequencing Grade Modified Recombinant Trypsin, and more. These products offer diverse characteristics and functions to suit different experimental requirements. Whether you need protein sequencing, protein digestion, or protein degradation, our products can meet your demands. Additionally, we offer proteases specifically targeting certain substrates, such as IdeZ Protease (IgG-specific) and Recombinant Active Human BACE1 (His-Tag). 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This series covers various enzyme classes, including Simvastatin Acyltransferase, Acetolactate Synthase, D-Amino Acid Oxidase, L-Glutamate Oxidase, L-Leucine Dehydrogenase, and more. Our Biochemical Enzyme series not only exhibits efficient catalytic properties but also holds great potential for a wide range of applications. These enzyme products can be used in studies of metabolic pathways, protein engineering, enzyme-catalyzed reactions, pharmaceutical research, and more. Whether in academic research or industrial applications, these enzyme products can provide reliable experimental results and data support. 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These products can help researchers better understand the mechanisms of intracellular signal transduction and provide important support for disease treatment and drug development. 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These high-quality magnetic beads find wide-ranging applications in protein purification, nucleic acid extraction, immunoprecipitation, protein-protein interaction studies, and more. We offer a variety of specifications and functionalities to suit different experimental needs. 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Our products exhibit high purity, strong reliability, and are suitable for a wide range of experimental designs and applications. 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Our Quick-Dissolve Pellets are designed to simplify the preparation of various buffers and solutions commonly used in biological, biochemical, and molecular biology experiments. These high-quality pellets are meticulously formulated to provide ease of use, consistency, and efficiency, allowing you to focus on your research rather than time-consuming buffer preparations. 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data-react-style="{&quot;backgroundRepeat&quot;:&quot;no-repeat&quot;,&quot;backgroundSize&quot;:&quot;cover&quot;,&quot;backgroundColor&quot;:&quot;transparent&quot;,&quot;backgroundPosition&quot;:&quot;50% 50%&quot;}"><style data-emotion="css 1tnf9eu">.css-1tnf9eu{position:absolute;top:0;left:0;width:100%;height:100%;line-height:1;-webkit-backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);backdrop-filter:blur(10px);-webkit-transition:all ease-in 0.2s;transition:all ease-in 0.2s;}.css-1tnf9eu.loaded{-webkit-backdrop-filter:blur(0px);-webkit-backdrop-filter:blur(0px);backdrop-filter:blur(0px);visibility:hidden;}</style><div class="blurred-layer css-1tnf9eu css-8mif150"></div><div class="waypoint"></div><a target="_self" href="https://www.sbsgenetech.com/_blog#_blog" class="s-blog-back-link s-font-body s-blog-body"><span class="left-arrow entypo-left-open-big"></span>Return to site</a><div class="table-row-wrap"><div class="container"><div class="sixteen columns"><a target="_self" href="https://www.sbsgenetech.com/_blog#_blog" class="s-blog-back-link"><span class="left-arrow entypo-left-open-big"></span>Return to site</a></div></div></div><div class="s-blog-header-content s-blog-padding s-edit-dark"><div class="container"><div class="sixteen columns"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-title s-blog-title" style="white-space:pre-wrap"><h1><div class="s-rich-text-wrapper" style="display: block;"><p class="s-rich-text-wrapper s-rich-text-wrapper"><strong>Congratulations to Our Customer for Published in Bioactive Materials (IF: 18)!</strong></p></div></h1></div></div></div><div class="s-blog-subtitle-wrapper"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-heading s-blog-subtitle" style="white-space:pre-wrap"><div class="s-rich-text-wrapper" style="display: block;"><p class="s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper s-rich-text-wrapper" style="font-size: 80%;">This study presents a nanoengineered peptide PROTACs (NP-PROTACs) strategy that simultaneously degrades β-catenin and STAT3 to inhibit colorectal cancer growth and improve the immune microenvironment.</p></div></div></div></div></div></div></div></div></div><div class="s-blog-header-bottom"><div class="container"><div class="sixteen columns"><div class="s-blog-info s-font-body"><span class="dot"> · </span><span class="s-blog-tags"><span class="s-blog-tag ">Publications,</span><span class="s-blog-tag last">News</span></span></div></div></div></div></div><div class="s-blog-body s-blog-padding"><div class="s-repeatable s-block s-component s-mh "><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;">On Sep 25th, research team from Fudan University published a groundbreaking research paper titled "Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy" in the journal "Bioactive Materials" <span style="color: #444444;">(impact factor: 18.0).</span>&nbsp;</p></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;">In colorectal cancer (CRC) research, β-catenin and STAT3 have been identified as key drivers of cancer growth, progression, and immune evasion. Their co-overexpression is strongly associated with poor prognosis in patients. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-catenin.</p></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;">Inspired by the PROteolysis TArgeting Chimera (PROTAC), researchers have developed a strategy of nanoengineered peptide PROTACs (NP-PROTACs) to simultaneously degrade β-catenin and STAT3. This novel treatment method involves coupling peptide PROTACs with DSPE-PEG via disulfide bonds and self-assembling into nanoparticles, thereby achieving effective degradation of both proteins.</p></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;">Studies have shown that the dual degradation of β-catenin and STAT3 mediated by NP-PROTACs exhibits a stronger synergistic antitumor effect compared to single-target treatments. This dual-target approach not only inhibits cancer cell growth and progression but also significantly enhances the infiltration of CD103+ dendritic cells and the cytotoxicity of T cells, alleviating the immunosuppressive microenvironment induced by β-catenin/STAT3 in CRC.</p></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;">The successful application of NP-PROTACs offers a new avenue for cancer therapy. By simultaneously degrading two pathogenic proteins, this strategy has the potential to overcome the limitations of current treatments and provide more effective therapeutic outcomes. As research progresses, NP-PROTACs are expected to become a new hope for the treatment of colorectal cancer and other types of cancer.</p></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;"><span style="display: inline-block">&nbsp;</span></p></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-image"><div><div class="s-component-content"><div class="s-img-wrapper"><div class="s-ratio-box" style="max-width:1472px;max-height:1196px"><div class="s-ratio-fill" style="padding-bottom:81.25%"></div><div class="s-img-wrapper"><img alt="broken image" title="" class="lazyload crop-default" data-description="" data-image-link="javascript:void(0);" width="1472" height="1196" src="//custom-images.strikinglycdn.com/res/hrscywv4p/image/upload/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_1/2311560/975597_3938.png" data-src="//custom-images.strikinglycdn.com/res/hrscywv4p/image/upload/c_limit,fl_lossy,h_9000,w_1200,f_auto,q_auto/2311560/975597_3938.png"/></div></div></div></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;"><span style="display: inline-block">&nbsp;</span></p></div></div></div></div></div></div></div><div class="s-block-item s-repeatable-item s-block-sortable-item s-blog-post-section s-narrow-margin blog-section"><div class="container"><div class="sixteen columns"><div class="s-blog-section-inner"><div class="s-component s-text"><div class=""><div class="s-component-content s-font-body" style="white-space:pre-wrap"><p style="text-align: justify;">In conjunction with the research study, the DNA transfection reagent is supplied by SBS Genetech. Since 2000, <a href="https://www.sbsgenetech.com/" data-type="undefined" target="_blank">SBS Genetech</a> has been at the forefront of providing solutions in life sciences. We offer safer, superior quality, and more cost-effective products to preeminent researchers in more than 60 countries, empowering them to make new discoveries in biology. Our products have been widely utilized in academic research, with results often published in leading academic journals like <em>Science</em>, <em>Cell</em>, <em>Cancer Cell</em>, and <em>Cell Metabolism</em>. 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