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cl"> <tr> <td> <a href="/" target="_blank" class="white-link">Total Articles</a> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">59</label> <br /> <label style="font-size: 14px;">(from Reference Citation Analysis)</label> <div id="RootHolder_SearchArticlePDFContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithPdf" type="checkbox" id="RootHolder_ArticlesWithPdf" class="ArticlesWithPdf" onclick="SearchArticleWithPDF();" /> <label for="ArticlesWithPdf">Article PDFs (12)</label> </div> <div id="RootHolder_SearchTCContainer" style="padding-top: 1rem;"> <input name="ctl00$RootHolder$ArticlesWithTC" type="checkbox" id="RootHolder_ArticlesWithTC" class="ArticlesWithTC" onclick="SearchArticleWithTC();" /> <label for="ArticlesWithTC">Cited by ≥ 1 (20)</label> </div> </div> <div class="mnavbar" id="SearchedNameTitle"> <div> Searched Name </div> </div> <div class="mnavbox" id="SearchedNameText"> <label 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Tumour necrosis factor inhibitors in Ulcerative colitis: real-world data on Therapeutic drug monitoring and evaluation of current treatment targets (STRIDE II). <em class='incite-journal-name' onclick='ShowInCiteJournal(2141);'>Ann Med</em> 2025;<b>57</b>:2424447. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39757985' target='_blank'>39757985</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721610' target='_blank'>PMC11721610</a> DOI: <a href='https://dx.doi.org/10.1080/07853890.2024.2424447' target='_blank'>10.1080/07853890.2024.2424447</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/07853890.2024.2424447','39757985', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1080/07853890.2024.2424447' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2141);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rp.tandfonline.com/submission/login' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/31/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/07/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv1" value="10.1080/07853890.2024.2424447" /> <div style="display: none" id="articleAbstract1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The benefit of therapeutic drug monitoring (TDM) and implementation of recommendations from the Selection of Therapeutic Targets in Inflammatory Bowel Disease (IBD, STRIDE) are discussed in the IBD community. We report real-world data in ulcerative colitis patients receiving first-line tumour necrosis factor inhibitor (TNFi) treatment followed by TDM, and assess how implementation of the STRIDE II recommendations might affect clinical practice. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Adult, biologically naïve UC patients starting TNFi between 2014 and 2021 at Oslo University Hospital were included in a medical chart review study, and data were collected at three and twelve months after the start of treatment. Target serum drug levels were defined as ≥7.5 mg/L for adalimumab and ≥5 mg/L for infliximab. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Of 141 included patients, 36% were in clinical and biochemical (combined) remission after twelve months. Among 102 treatment persistent patients, 54% were in combined remission after twelve months. Target drug level at three months was associated with clinical remission at twelve months (OR = 2.97, 95% CI [1.24-7.12]) and biochemical remission at twelve months (OR = 2.64, 95% CI [1.03-6.77]). In total, 56% of recorded dosage adjustments were related only to serum drug levels. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Combined remission rates at twelve months for treatment persistent patients suggest that 46% should have been considered for a change of treatment according to the STRIDE II recommendations. A majority of dosage adjustments were made proactively. Target drug level at three months was associated with remission at twelve months and supports the use of proactive TDM. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22STRIDE+II%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">STRIDE II</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Therapeutic+drug+monitoring%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Therapeutic drug monitoring</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ulcerative+colitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ulcerative colitis</a></li></ul> <a href="javascript:ShowArticleKeywords(1);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh1" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/drug therapy</a></li><li><a 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id="citation2" class="article-citation"> <b>Samuels A</b>, Irie K, Mizuno T, Reifenberg J, Punt N, Vinks AA, Minar P. Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(7273);'>Clin Transl Sci</em> 2025;<b>18</b>:e70086. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39985779' target='_blank'>39985779</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846607' target='_blank'>PMC11846607</a> DOI: <a href='https://dx.doi.org/10.1111/cts.70086' target='_blank'>10.1111/cts.70086</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/cts.70086','39985779', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/cts.70086' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7273);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/31/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/10/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/24/2025]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv2" value="10.1111/cts.70086" /> <div style="display: none" id="articleAbstract2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">The use of model-informed precision dosing to personalize infliximab has been shown to improve both the acquisition of concentration targets and clinical outcomes during maintenance. Current iterations of infliximab pharmacokinetic models include time-varying covariates of drug clearance, however, not accounting for the expected improvements in the covariates can lead to indiscriminate use of higher infliximab doses and imprecise drug exposure. The aim was to identify changes in the four biomarkers associated with infliximab clearance (Xiong et al. model) and determine if integration of these dynamic changes would improve model performance during induction and early maintenance. We analyzed two cohorts of children receiving infliximab for Crohn's Disease. The Emax method was used to assess time-varying changes in covariates. Model performance (observed vs. predicted infliximab concentrations) was evaluated using median percentage error (bias) and median absolute percentage error (precision). The combined cohorts included 239 Crohn's disease patients. We found from baseline to dose 4, the maximum changes in weight, albumin, erythrocyte sedimentation rate, and neutrophil CD64 were 4.7%, +11.7%, -62.4%, and -26.5%, respectively. We also found the use of baseline covariates alone to forecast future trough concentration was inferior to the Emax time-varying method with a significant improvement observed in bias (doses 2, 3, and 4) and precision (doses 2 and 4). The integration of the four time-varying biomarkers of drug clearance with pharmacokinetic modeling improved the accuracy and precision of the predictions. This novel strategy may be key to improving drug exposure, minimizing indiscriminate dosing strategies, and reducing healthcare costs. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a 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href="javascript:ShowArticleMeSH(2);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant2" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width: 40px; text-align: center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Khan D</b>, Ahmed N, Muhammad A, Shah KU, Mir M, Rehman AU. A macromolecule infliximab loaded reverse nanomicelles-based transdermal hydrogel: An innovative approach against rheumatoid arthritis. <em>BIOMATERIALS ADVANCES</em> 2025;<b>167</b>:214093. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39492133' target='_blank'>39492133</a> DOI: <a href='https://dx.doi.org/10.1016/j.bioadv.2024.214093' target='_blank'>10.1016/j.bioadv.2024.214093</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.bioadv.2024.214093','39492133', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(3);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.bioadv.2024.214093' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv3" value="10.1016/j.bioadv.2024.214093" /> <div style="display: none" id="articleAbstract3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Infliximab (IFX) is used as a biotherapeutic agent for the treatment of rheumatoid arthritis (RA); however, its biological activity is lost orally because of variations in gastric pH and enzymatic degradation, and reduced bioavailability. The authors have tried to improve the efficacy of macromolecule delivery through transdermal route. Polycaprolactone-Polyethylene glycol-Polycaprolactone (PCL-PEG-PCL) triblock copolymer previously synthesized and was used as an efficient carrier for the preparation of IFX loaded reverse nanomicelles (IFX-RNMs). The RNMs were fabricated via nanoprecipitation technique, characterized and then were incorporated into a Carbopol-based hydrogel with eucalyptus oil (EO) as a penetration enhancer. The optimized RNMs had a particle size of 72.32 nm and an encapsulation efficiency of 83 %. In vitro release, exhibited a sustained pattern of IFX from the prepared carrier system, ex-vivo skin permeation and fluorescence microscopic studies revealed that IFX-RNMs loaded hydrogel with EO markedly improved permeation. An in vivo study was carried out on a CFA-induced RA mice model that revealed significant improvements in the results of behavioral parameters, biochemical assays, histopathological and radiological analysis. Overall, the results concluded that the IFX-RNMs loaded hydrogel can be used as a suitable approach for treating RA. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Macromolecular+delivery%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Macromolecular delivery</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Reverse+nanomicelles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Reverse nanomicelles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rheumatoid arthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transdermal+hydrogel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transdermal hydrogel</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant3" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width: 40px; text-align: center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Iborra M</b>, Caballol B, Garrido A, Huguet JM, Mesonero F, Ponferrada Á, Arias García L, Boscá Watts MM, Fernández Prada SJ, Brunet Mas E, Gutiérrez Casbas A, Cerrillo E, Ordás I, Ruiz L, García de la Filia I, Escobar Ortiz J, Sicilia B, Ricart E, Domènech E, Nos P. Subcutaneous Infliximab Cutoff Points in Patients With Inflammatory Bowel Disease: Data From the ENEIDA Registry. <em class='incite-journal-name' onclick='ShowInCiteJournal(13594);'>J Crohns Colitis</em> 2025;<b>19</b>:jjae127. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39171615' target='_blank'>39171615</a> DOI: <a href='https://dx.doi.org/10.1093/ecco-jcc/jjae127' target='_blank'>10.1093/ecco-jcc/jjae127</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/ecco-jcc/jjae127','39171615', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1093/ecco-jcc/jjae127' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13594);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/ecco-jcc' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv4" value="10.1093/ecco-jcc/jjae127" /> <div style="display: none" id="articleAbstract4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND AIMS</div><div class="abstract-content">Switching from intravenous infliximab (IV-IFX) to subcutaneous biosimilar infliximab (SC-IFX) has been shown to safely maintain clinical remission and increase drug levels in patients with Crohn's disease (CD) and ulcerative colitis (UC). The aim of this study was to evaluate long-term outcomes after switching from IV-IFX to SC-IFX, including the drug concentration thresholds for maintaining remission and other predictors for loss of response after the switch. </div><div class="abstract-label">METHODS</div><div class="abstract-content">This multicenter observational study involved CD and UC patients who were in clinical remission for at least 24 weeks and were scheduled to switch from IV-IFX to SC-IFX. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Two hundred and twenty patients were included (74 UC [34%] and 146 CD [66%]). IV-IFX was administered for 52.5 months (range 25-89). Before switch, 106 (49%) patients were receiving intensified IV-IFX. While SC-IFX levels significantly increased following the switch from IV-IFX to SC-IFX, clinical parameters, C-reactive protein, and fecal calprotectin remained unchanged during follow-up. SC-IFX levels were significantly higher in patients receiving the standard IV-IFX dose than in those receiving the intensified dose. Immunomodulatory therapy at baseline and perianal disease had no effect on IFX trough levels, whereas higher body mass index was associated with increased levels. The suggested optimal SC-IFX cutoff concentration for clinical and biochemical remissions based on receiver operating characteristic analysis was 12.2 μg/mL (area under the curve [AUC]: 0.62) at Week 12 and 13.2 μg/mL (AUC: 0.57) at Week 52. Drug persistence was 92% at Week 52, with a good safety profile. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Switching from IV-IFX to SC-IFX safely maintains long-term remission in patients with CD and UC. 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target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant4" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width: 40px; text-align: center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Hong SN</b>, Song JH, Kim SJ, Park YH, Choi CW, Kim JE, Kim ER, Chang DK, Kim YH. Subcutaneous Infliximab Concentration Thresholds for Mucosal and Transmural Healing in Patients With Crohn's Disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(1676);'>Aliment Pharmacol Ther</em> 2025;<b>61</b>:313-322. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39552401' target='_blank'>39552401</a> DOI: <a href='https://dx.doi.org/10.1111/apt.18354' target='_blank'>10.1111/apt.18354</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/apt.18354','39552401', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(5);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1111/apt.18354' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(1676);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/apt?8' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/22/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/19/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv5" value="10.1111/apt.18354" /> <div style="display: none" id="articleAbstract5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Predose trough concentrations (Ctrough) of intravenous infliximab (IV-IFX) during maintenance therapy are associated with therapeutic outcomes in patients with Crohn's disease (CD). A subcutaneous formulation of infliximab (SC-IFX) has shown high Ctrough values due to its favourable pharmacokinetics. </div><div class="abstract-label">AIMS</div><div class="abstract-content">To evaluate the association of Ctrough of SC-IFX with therapeutic outcomes and the threshold of SC-IFX Ctrough for achieving mucosal healing (MH) and transmural healing (TH) in patients with CD. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We performed this cross-sectional study in patients with CD who had received SC-IFX maintenance therapy for ≥ 6 months. We measured SC-IFX Ctrough immediately before SC-IFX injection. We performed ileocolonoscopy/single-balloon enteroscopy and/or magnetic resonance enterography within 3 months of SC-IFX Ctrough measurement. MH was defined as SES-CD-ulcerated surface subscore of 0. TH was defined as simplified MaRIA score of 0. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">We enrolled 124 patients with MH in 77.9% (74/95) and TH in 36.3% (37/102). SC-IFX Ctrough was significantly higher in patients with MH (24.1 vs.16.9 μg/mL; p = 0.001) and TH (26.0 vs. 20.5 μg/mL; p = 0.007) than in those without. ROC analysis identified that the threshold of SC-IFX Ctrough for MH and TH were 17.5 and 30.3 μg/mL, respectively. Multivariate logistic regression showed that SC-IFX Ctrough was significantly associated with MH (OR 1.16; 95% CI 1.05-1.27; p = 0.002) and TH (OR 1.08; 95% CI 1.02-1.14; p = 0.005). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">SC-IFX Ctrough was positively associated with MH (≥ 18 μg/mL) and TH (≥ 30 μg/mL) in patients with CD, which may guide treatment decisions to optimise therapeutic response in the era of treat-to-target. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn%27s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn's disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mucosal+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mucosal healing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22subcutaneous+infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">subcutaneous infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transmural+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transmural healing</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cross-Sectional+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cross-Sectional Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+Mucosa%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal Mucosa/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Intestinal+Mucosa%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Intestinal Mucosa/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Injections%2c+Subcutaneous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Injections, Subcutaneous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wound+Healing%2fdrug+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wound Healing/drug effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant5" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea+(NRF)+grant+funded+by+the+Korea+government+(MSIP)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">2022R1A2B5B02002092 National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Future+Medicine+20*30+Project+of+the+Samsung+Medical+Center%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SMO122004 Future Medicine 20*30 Project of the Samsung Medical Center</a></li></ul> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width: 40px; text-align: center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>De Sutter PJ</b>, Gasthuys E, Vermeulen A. Comparison of monoclonal antibody disposition predictions using different physiologically based pharmacokinetic modelling platforms. <em class='incite-journal-name' onclick='ShowInCiteJournal(14933);'>J Pharmacokinet Pharmacodyn</em> 2024;<b>51</b>:639-651. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37952005' target='_blank'>37952005</a> DOI: <a href='https://dx.doi.org/10.1007/s10928-023-09894-4' target='_blank'>10.1007/s10928-023-09894-4</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1007%2fs10928-023-09894-4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1007%2fs10928-023-09894-4')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10928-023-09894-4','37952005', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(6);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s10928-023-09894-4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14933);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/14/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv6" value="10.1007/s10928-023-09894-4" /> <div style="display: none" id="articleAbstract6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Physiologically based pharmacokinetic (PBPK) models can be used to leverage physiological and in vitro data to predict monoclonal antibody (mAb) concentrations in serum and tissues. However, it is currently not known how consistent predictions of mAb disposition are across PBPK modelling platforms. In this work PBPK simulations of IgG, adalimumab and infliximab were compared between three platforms (Simcyp, PK-Sim, and GastroPlus). Accuracy of predicted serum and tissue concentrations was assessed using observed data collected from the literature. Physiological and mAb related input parameters were also compared and sensitivity analyses were carried out to evaluate model behavior when input values were altered. Differences in serum kinetics of IgG between platforms were minimal for a dose of 1 mg/kg, but became more noticeable at higher dosages (> 100 mg/kg) and when reference (healthy) physiological input values were altered. Predicted serum concentrations of both adalimumab and infliximab were comparable across platforms, but were noticeably higher than observed values. Tissue concentrations differed remarkably between the platforms, both for total- and interstitial fluid (ISF) concentrations. The accuracy of total tissue concentrations was within a three-fold of observed values for all tissues, except for brain tissue concentrations, which were overpredicted. Predictions of tissue ISF concentrations were less accurate and were best captured by GastroPlus. Overall, these simulations show that the different PBPK platforms generally predict similar mAb serum concentrations, but variable tissue concentrations. Caution is therefore warranted when PBPK models are used to simulate effect site tissue concentrations of mAbs without data to verify the predictions. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adalimumab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adalimumab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biodistribution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biodistribution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IgG%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IgG</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monoclonal+antibodies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monoclonal antibodies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Physiologically+based+pharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Physiologically based pharmacokinetics</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Biological%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Biological</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adalimumab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adalimumab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adalimumab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adalimumab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Distribution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Distribution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computer+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computer Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunoglobulin+G%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunoglobulin G/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant6" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width: 40px; text-align: center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Ferreira AI</b>, Lima Capela T, Arieira C, Xavier S, Cotter J. Subcutaneous versus intravenous infliximab therapy - a real-world study: toward higher drug concentrations. <em class='incite-journal-name' onclick='ShowInCiteJournal(8764);'>Eur J Gastroenterol Hepatol</em> 2024;<b>36</b>:1314-1318. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39166409' target='_blank'>39166409</a> DOI: <a href='https://dx.doi.org/10.1097/meg.0000000000002835' target='_blank'>10.1097/meg.0000000000002835</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1097/meg.0000000000002835','39166409', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1097/meg.0000000000002835' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(8764);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ejgh/mainpage.html' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv7" value="10.1097/meg.0000000000002835" /> <div style="display: none" id="articleAbstract7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Recently, a formula of subcutaneous infliximab (SC-IFX) has been approved for inflammatory bowel disease (IBD), demonstrating a better pharmacokinetic and immunogenic profiles, compared to intravenous infliximab (IV-IFX), with similar efficacy and safety. </div><div class="abstract-label">AIM</div><div class="abstract-content">The aim of this study is to evaluate the clinical, biochemical, and pharmacological outcomes of IBD patients in clinical remission, who switched from IV-IFX to SC-IFX, with a follow-up period of 6 months. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Retrospective cohort study, including IBD patients in clinical remission, previously medicated with IV-IFX, who switched to SC-IFX 120 mg every other week. Biochemical parameters were evaluated before the switch and 6 months after, namely infliximab serum concentrations, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fecal calprotectin. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Included 41 patients in clinical remission, 32 with Crohn's disease (78.0%) and 9 with ulcerative colitis (22.0%). All patients maintained clinical remission during the 6 months after the switch, with a treatment persistence rate of 100%, and no patients requiring corticosteroid therapy, switching back to IV-IFX, or IBD-related hospitalization. The mean infliximab serum concentrations were significantly higher after 6 months of SC-IFX (17.3 ± 6.6 vs. 9.1 ± 5.5 µg/ml, P < 0.001). However, there were no differences between values of ESR, CRP, and fecal calprotectin, before and after the switch ( P = 0.791, P = 0.246, and P = 0.639). Additionally, none of the patients developed antibodies to infliximab. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Switching from IV-IFX to SC-IFX in IBD patients in clinical remission is effective and leads to higher infliximab serum concentrations, regardless of the combination with immunomodulatory therapy. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh7" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/blood</a></li><li><a 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right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width: 40px; text-align: center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Lee B</b>, Kim M, Kim ER, Hong SN, Chang DK, Kim YH. Effectiveness of switching to subcutaneous infliximab in inflammatory bowel disease patients with inadequate biochemical response during intravenous administration. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2024;<b>14</b>:24347. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39420116' target='_blank'>39420116</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487171' target='_blank'>PMC11487171</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-024-75693-7' target='_blank'>10.1038/s41598-024-75693-7</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-024-75693-7','39420116', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(8);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(8);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-024-75693-7' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/08/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv8" value="10.1038/s41598-024-75693-7" /> <div style="display: none" id="articleAbstract8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">Infliximab (IFX) has transformed the management of inflammatory bowel diseases (IBD). While intravenous (IV) IFX has been effective, a subcutaneous (SC) formulation offers advantages in convenience and cost. However, there is lack of evidence regarding the transition from IV to SC-IFX, especially for patients with inadequate responses. This study investigates the effectiveness of switching from IV to SC-IFX in patients with inadequate responses during IV maintenance therapy. A retrospective study enrolled IBD patients who transitioned to SC-IFX after demonstrating inadequate responses during IV maintenance therapy. The study collected data of demographics of patients and dose and therapies administered prior to the IV-IFX. Primary outcomes included improvements in C-reactive protein (CRP) or fecal calprotectin (FC) levels. This study evaluated the trough levels and its differences between pre- and post-switching. Among 44 patients included, 10 exhibited CRP elevation before the switch, with 6 showing normalization post-switch. Similarly, 42 patients had elevated FC levels pre-switch, with 26 experiencing reductions post-switch. Trough levels increased after the switch. However, there were no significant differences between responders and non-responders. This study is the first study to investigate the transition therapy of IV to SC-IFX in patients with inadequate response. This suggests that SC-IFX could be a viable alternative in the management of IBD. However, further research is necessary to evaluate its efficacy in a larger population of patients who exhibit inadequate responses during IV-IFX maintenance therapy. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inadequate+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inadequate response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Subcutaneous+administration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Subcutaneous administration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transition+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transition therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh8" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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<td> <div id="citation9" class="article-citation"> <b>Colman RJ</b>, Vuijk SA, Mathôt RAA, Van Limbergen J, Jongsma MME, Schreurs MWJ, Minar P, de Ridder L, D'Haens GRAM. Infliximab Monotherapy vs Combination Therapy for Pediatric Crohn's Disease Exhibit Similar Pharmacokinetics. <em class='incite-journal-name' onclick='ShowInCiteJournal(11161);'>Inflamm Bowel Dis</em> 2024;<b>30</b>:1678-1685. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38167922' target='_blank'>38167922</a> DOI: <a href='https://dx.doi.org/10.1093/ibd/izad307' target='_blank'>10.1093/ibd/izad307</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/ibd/izad307','38167922', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(9);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/ibd/izad307' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11161);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/ibd/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/31/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/05/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv9" value="10.1093/ibd/izad307" /> <div style="display: none" id="articleAbstract9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The use of concomitant azathioprine may improve efficacy and pharmacokinetic (PK) properties of infliximab (IFX) but is also associated with an increased risk of adverse events. Proactive therapeutic drug monitoring (pTDM) of IFX monotherapy is an alternative strategy to improve PK. The aim of this study was to evaluate whether IFX with an immunomodulator (combo) has PK benefits over IFX-pTDM (mono) in pediatric Crohn's disease (CD). </div><div class="abstract-label">METHODS</div><div class="abstract-content">This PK analysis included pediatric CD patients who started either IFX combo (TISKids study) or IFX mono with pTDM (REFINE cohort). Combo and mono IFX trough levels (TLs) and antibodies-to-infliximab were assessed at infusion 3, 4, and 5. A population PK model was built to compare IFX PK outcomes (clearance [CL], TLs and cumulative exposure) between combo and mono groups at infusion 4 and 5. Clinical response and steroid-free clinical remission (SFCR) was assessed at infusion 4 and 5. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">This study included 128 pediatric CD patients (66 mono and 62 combo). At infusion 5, there was no significant difference between mono and combo median TLs 4.1 µg/mL (2.1, 7.8) vs 5.9 µg/mL (3.2, 9.4; P = .14) or median CL 0.26 L/d (0.21, 0.32) vs 0.26 L/d (0.21, 0.33; P = .81). Mono patients had a lower SFCR rate at infusion 5 (53% [31 of 59] vs 80% [32 of 40]; P = .01). Clinical response rates were significantly higher among combo than mono patients at both infusion 4 and 5. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">This study suggests that there are no PK differences (TLs and CL) between combo and mono therapy in pediatric CD patients who started IFX. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords9" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anti-TNF+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anti-TNF therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22children%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Netherlands+Organisation+for+Health+Research+and+Development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">113202001 Netherlands Organisation for Health Research and Development</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width: 40px; text-align: center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Park YC</b>, Kim JH, Kim SH, Lee JH, Hong JH, Jung J, Sunwoo J. Pharmacokinetic comparison of subcutaneously administered CT-P13 (biosimilar of infliximab) via autoinjector and pre-filled syringe in healthy participants. <em class='incite-journal-name' onclick='ShowInCiteJournal(7273);'>Clin Transl Sci</em> 2024;<b>17</b>:e70037. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39351819' target='_blank'>39351819</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11443321' target='_blank'>PMC11443321</a> DOI: <a href='https://dx.doi.org/10.1111/cts.70037' target='_blank'>10.1111/cts.70037</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/cts.70037','39351819', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/cts.70037' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7273);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/16/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/03/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv10" value="10.1111/cts.70037" /> <div style="display: none" id="articleAbstract10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-content">CT-P13, a biosimilar of infliximab, is used to treat inflammatory diseases that arise from immune system complications, resulting in excessive and persistent inflammation. The subcutaneous (SC) formulation of CT-P13 overcomes the drawback of prolonged administration associated with the intravenous (IV) infliximab biosimilar, necessitating autoinjector (AI) administration. This randomized, open-label, two-arm, parallel-group, single-dose clinical pharmacology study aimed to evaluate the pharmacokinetics (PK) and safety of CT-P13 SC administration via AI compared with the existing pre-filled syringe (PFS) method. A total of 147 healthy participants were randomized into two groups, of which 139 completed the study. Blood samples were collected from before CT-P13 SC administration to 2016 h after the start of the administration. Serum concentrations were analyzed using the Meso Scale Discovery electrochemiluminescence method. Geometric mean ratios (90% confidence interval) of the AUCinf (areas under the concentration-time curve from zero to infinity) and Cmax (The maximum serum concentration) for CT-P13 SC AI versus CT-P13 SC PFS groups, were 94.15% (85.02%-104.26%), 92.48% (84.66%-101.01%), respectively. CT-P13 SC AI and CT-P13 SC PFS achieved comparable PK because the 90% CI was within the predefined equivalence margin. At the end of the study, immunogenicity results revealed that 70 (97.22%) and 73 (98.65%) participants tested positive for anti-drug antibody (ADA) in the CT-P13 SC AI and CT-P13 SC PFS groups, respectively. They were tested positive for neutralizing antibodies. No other significant safety differences were observed between the treatment groups. In conclusion, both administrations demonstrated PK equivalence and were both safe and well-tolerated. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosimilar+Pharmaceuticals%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosimilar Pharmaceuticals/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosimilar+Pharmaceuticals%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosimilar Pharmaceuticals/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosimilar+Pharmaceuticals%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosimilar Pharmaceuticals/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosimilar+Pharmaceuticals%2fadverse+effects%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosimilar Pharmaceuticals/adverse effects</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Injections%2c+Subcutaneous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Injections, Subcutaneous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Syringes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Syringes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fimmunology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/immunology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Healthy+Volunteers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Healthy Volunteers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Therapeutic+Equivalency%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Therapeutic Equivalency</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Area+Under+Curve%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Area Under Curve</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant10" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width: 40px; text-align: center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Roblin X</b>, Little RD, Mathieu N, Paul S, Nancey S, Barrau M, Sparrow MP. Therapeutic drug monitoring in inflammatory bowel disease: recent developments. <em class='incite-journal-name' onclick='ShowInCiteJournal(9191);'>Expert Rev Gastroenterol Hepatol</em> 2024;<b>18</b>:575-586. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39382556' target='_blank'>39382556</a> DOI: <a href='https://dx.doi.org/10.1080/17474124.2024.2409300' target='_blank'>10.1080/17474124.2024.2409300</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/17474124.2024.2409300','39382556', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(11);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/17474124.2024.2409300' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9191);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/erh' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/23/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/10/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv11" value="10.1080/17474124.2024.2409300" /> <div style="display: none" id="articleAbstract11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">Therapeutic Drug Monitoring (TDM) has an important role in the management of inflammatory bowel disease (IBD) patients on infliximab (IFX) or adalimumab and is recommended in IBD patients presenting a loss of response under anti TNF agent. But, TDM was not recommended for others biotherapies. </div><div class="abstract-label">AREAS COVERED</div><div class="abstract-content">Analyzing all publications about TDM and biologics in IBD patients, we reported the major results for each biotherapy. </div><div class="abstract-label">EXPERT OPINION</div><div class="abstract-content">Emerging data suggest that TDM will probably be similarly useful forIFX SC. In contrast, there is no demonstrated clinical benefit to the use of TDM with golimumab. For vedolizumab results for the use of both reactive and proactive TDM are discordant. For ustekinumab, data supports the existence of an exposure response relationship, albeit of a lesser magnitude than with anti-TNF agents. Finally, recent data from small case series suggests that TDM could be valuable in optimizing anti-IL23 agents, particularly risankizumab, but this requires further clarification. Consistent with the new concept of 'proactive' strategy, recent data support the utility of dashboard-driven model informed precision dosing (MIDP) of anti-TNF agents, in particular infliximab. Dashboards are software systems using Bayesian population pharmacokinetic modelling to individualize recommendations for target drug levels. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords11" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Therapeutic+drug+monitoring%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Therapeutic drug monitoring</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biologic+therapies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biologic therapies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22proactive+strategy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">proactive strategy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22reactive+strategy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">reactive strategy</a></li></ul> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh11" class="article-abstract"> <b style="display: block; 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padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width: 40px; text-align: center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Srinivasan A</b>, van Langenberg D, De Cruz P, Segal J, Vasudevan A, Upton RN. Treatment Targets Should Influence Choice of Infliximab Dose Intensification Strategy in Inflammatory Bowel Disease: A Pharmacokinetic Simulation Study. <em class='incite-journal-name' onclick='ShowInCiteJournal(3489);'>BioDrugs</em> 2024;<b>38</b>:691-702. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39168947' target='_blank'>39168947</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358351' target='_blank'>PMC11358351</a> DOI: <a href='https://dx.doi.org/10.1007/s40259-024-00673-2' target='_blank'>10.1007/s40259-024-00673-2</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s40259-024-00673-2','39168947', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(12);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(12);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1007/s40259-024-00673-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3489);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/23/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv12" value="10.1007/s40259-024-00673-2" /> <div style="display: none" id="articleAbstract12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The optimal infliximab dose intensification strategy to address loss of response associated with subtherapeutic infliximab trough levels remains uncertain, as does whether post-intensification trough and treatment targets should influence this decision. </div><div class="abstract-label">OBJECTIVES</div><div class="abstract-content">This pharmacokinetic simulation study aimed to identify infliximab dose intensification strategies capable of achieving post-intensification infliximab trough thresholds associated with clinical and objective treatment targets in Crohn's disease and ulcerative colitis. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A validated pharmacokinetic infliximab model, applied to 200 simulated patients, identified those with subtherapeutic (< 3.00 mg/L) trough levels after 30 weeks of standard (5 mg/kg 8-weekly) dosing, and subsequently applied 10 dose intensification strategies over a further 32 weeks. The proportion of simulations achieving 32-week post-intensification infliximab trough levels associated with endoscopic remission (ulcerative colitis > 7.50 mg/L, Crohn's disease > 9.70 mg/L) was the primary outcome, with perianal fistula healing (Crohn's disease > 10.10 mg/L) and clinical improvement (ulcerative colitis > 3.70 mg/L, Crohn's disease > 7.00mg/L) evaluated as secondary outcomes. All outcomes were stratified by intensity of dose intensification, with standard (≤ 10 mg/kg 8-weekly or 5 mg/kg 4-weekly; n = 5) and intensive (> 10 mg/kg 8-weekly or 5 mg/kg 4-weekly; n = 5) dosing strategies defined, respectively. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The median pre-intensification infliximab trough level was 0.91 mg/L (interquartile range 1.37). Intensive dosing strategies were more likely to achieve infliximab trough concentrations associated with endoscopic remission (ulcerative colitis 36.48% vs. 10.80%, Crohn's disease 25.98 vs. 4.68%), perianal fistula healing (24.52% vs. 4.36%) and clinical improvement (ulcerative colitis 61.90% vs. 34.86%, Crohn's disease 40.32 vs. 12.08%) than standard intensification strategies (all p < 0.01). When controlling for cumulative (mg/kg) infliximab dose over 32 weeks, strategies that concurrently dose increased and interval shortened achieved the highest infliximab trough levels (all p < 0.01). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">This simulation-based analysis highlights the potential of using post-intensification infliximab trough thresholds associated with aspirational treatment targets in Crohn's disease and ulcerative colitis to guide choice of infliximab dose intensification strategy. Intensive dose intensification strategies, particularly those that concurrently dose increase and interval shorten, appear to achieve higher infliximab levels than standard dose intensification strategies. This may be particularly important in the pursuit of stringent endpoints, such as endoscopic remission and fistula healing, which have been consistently associated with higher infliximab trough levels. These findings require validation across real-world cohorts. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dose-Response+Relationship%2c+Drug%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dose-Response Relationship, Drug</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computer+Simulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computer Simulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant12" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22University+of+Melbourne%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">University of Melbourne</a></li></ul> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width: 40px; text-align: center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Heikal OS</b>, van Rheenen PF, Touw DJ, Kosterink JGW, Maurer M, Koomen JV, Chelle P, Mian P. Infliximab in paediatric inflammatory bowel disease: External evaluation of population pharmacokinetic models. <em class='incite-journal-name' onclick='ShowInCiteJournal(4285);'>Br J Clin Pharmacol</em> 2024;<b>90</b>:2200-2214. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38845210' target='_blank'>38845210</a> DOI: <a href='https://dx.doi.org/10.1111/bcp.16126' target='_blank'>10.1111/bcp.16126</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1111/bcp.16126','38845210', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1111/bcp.16126' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4285);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/27/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/03/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/30/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv13" value="10.1111/bcp.16126" /> <div style="display: none" id="articleAbstract13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">AIMS</div><div class="abstract-content">Use of infliximab (IFX) has improved outcomes in children with inflammatory bowel disease (IBD). However, a proportion of patients does not respond to IFX or loses response over time. Population pharmacokinetic (PopPK) modelling is a promising approach for IFX dose optimization, but with the increasing number of PopPK models in literature, model evaluation is essential. The aims of this study are: (i) to validate the predictive performance of existing IFX PopPK models using a cohort of children with IBD; and (ii) to perform a Bayesian estimation of the most suitable model to predict the next IFX concentrations. </div><div class="abstract-label">METHODS</div><div class="abstract-content">PubMed was searched for IFX PopPK models in children. Selected models were rebuilt and analysed using R. Model performance was assessed through goodness-of-fit-plots, residuals against time, prediction error and prediction-corrected visual predictive checks. The validation cohort consisted of 73 children with IBD who were treated with IFX in our centre between 2017 and 2023 (340 IFX measurements). </div><div class="abstract-label">RESULTS</div><div class="abstract-content">We identified 9 PopPK models. Model bias for individual predicted values ranged from -9.29% to 8.01% compared to bias for population predicted values. The model by Vande Casteele et al. demonstrated superior performance (individual predicted bias 2.13, population predicted bias -6.11); upon Bayesian estimation, it predicted induction trough levels with median error of 12.95% but had a median error of -69% predicting maintenance concentrations. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The model by Vande Casteele et al. displayed superior performance in initial evaluations but had a high error in estimating next IFX levels and can only be used in practice to predict induction levels. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IBD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IBD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22PopPK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">PopPK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TDM%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TDM</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22children%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">children</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastroenterology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastroenterology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumour+necrosis+factor%e2%80%90%ce%b1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumour necrosis factor‐α</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bayes+Theorem%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bayes Theorem</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Biological%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Biological</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dose-Response+Relationship%2c+Drug%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dose-Response Relationship, Drug</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant13" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width: 40px; text-align: center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Magro F</b>, Fernandes S, Patita M, Arroja B, Lago P, Rosa I, Tavares de Sousa H, Ministro P, Mocanu I, Vieira A, Castela J, Moleiro J, Roseira J, Cancela E, Sousa P, Portela F, Correia L, Moreira P, Dias S, Afonso J, Danese S, Peyrin-Biroulet L, Vucicevic KM, Santiago M. The Influence of Subclinical Active Inflammation on IFX Pharmacokinetic Modeling and Disease Progression Assessment: Findings from a Prospective Real-World Study in Inflammatory Bowel Disease Patients. <em class='incite-journal-name' onclick='ShowInCiteJournal(13594);'>J Crohns Colitis</em> 2024;<b>18</b>:1102-1112. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38243908' target='_blank'>38243908</a> DOI: <a href='https://dx.doi.org/10.1093/ecco-jcc/jjae014' target='_blank'>10.1093/ecco-jcc/jjae014</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/ecco-jcc/jjae014','38243908', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(14);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1093/ecco-jcc/jjae014' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13594);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/ecco-jcc' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv14" value="10.1093/ecco-jcc/jjae014" /> <div style="display: none" id="articleAbstract14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND AIMS</div><div class="abstract-content">Effective management of inflammatory bowel disease (IBD) relies on a comprehensive understanding of infliximab (IFX) pharmacokinetics (PK). This study's primary goal was to develop a robust PK model, identifying key covariates influencing IFX clearance (CL), while concurrently evaluating the risk of disease progression during the maintenance phase of IBD treatment. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The multicenter, prospective, real-world DIRECT study was conducted in several care centers, which included 369 IBD patients in the maintenance phase of IFX therapy. A two-compartment population PK model was used to determine IFX CL and covariates. Logistic and Cox regressions were applied to elucidate the associations between disease progression and covariates embedded in the PK model. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The PK model included the contributions of weight, albumin, antidrug antibody (ADA), and fecal calprotectin (FC). On average, higher ADA, FC concentration and weight, and lower albumin concentration resulted in higher IFX CL. In the multivariate regression analyses, FC levels influenced the odds of disease progression in the majority of its definitions, when adjusted for several confounding factors. Additionally, alongside FC, both IFX and CL demonstrated a significant impact on the temporal aspect of disease progression. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">In this 2-year real-world study, readily available clinical covariates, notably FC, significantly impacted IFX availability in IBD patients. We demonstrated that subclinical active inflammation, as mirrored by FC or CRP, substantially influenced IFX clearance. Importantly, FC emerged as a pivotal determinant, not only of IFX pharmacokinetics but also of disease progression. These findings underscore the need to integrate FC into forthcoming IFX pharmacokinetic models, amplifying its clinical significance. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pharmacokinetic+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pharmacokinetic model</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocyte+L1+Antigen+Complex%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocyte L1 Antigen Complex/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Feces%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Feces/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Body+Weight%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Body Weight</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/drug therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant14" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Portuguese+Study+Group+in+Inflammatory+Bowel+Disease+(GEDII)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Portuguese Study Group in Inflammatory Bowel Disease (GEDII)</a></li></ul> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width: 40px; text-align: center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Nones RB</b>, Miranda EF, Marçal GDN, Baraúna FDSB, Loures MR, Senger PC, Magro DO, Kotze PG. Infliximab serum concentrations in luminal Crohn's disease and its relationship with disease activity: A multicentric cross-sectional study. <em>GASTROENTEROLOGIA Y HEPATOLOGIA</em> 2024;<b>47</b>:711-720. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38160706' target='_blank'>38160706</a> DOI: <a href='https://dx.doi.org/10.1016/j.gastrohep.2023.12.011' target='_blank'>10.1016/j.gastrohep.2023.12.011</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.gastrohep.2023.12.011','38160706', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(15);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.gastrohep.2023.12.011' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/24/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/03/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv15" value="10.1016/j.gastrohep.2023.12.011" /> <div style="display: none" id="articleAbstract15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">OBJECTIVES</div><div class="abstract-content">In Latin America, experience with monitoring serum Infliximab (IFX) concentrations is scarce. Our study aimed to compare IFX serum concentrations between patients with active disease or in remission. </div><div class="abstract-label">PATIENTS AND METHODS</div><div class="abstract-content">A cross-sectional study was performed in patients with luminal Crohn's disease (CD) during maintenance treatment with IFX. Patients were classified as in remission or disease activity according to clinical scores and endoscopic, radiological, and laboratory markers. A comparison of IFX trough levels between the two groups was performed. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">80 CD patients were included [41 (51%) in remission and 39 (49%) with active disease]. In the analysis of general disease activity, the median serum levels of IFX in patients with remission and with active CD were 5.63 [0.03-14.40] vs. 3.84 [0.03-14.40] (p=0.287). Furthermore, there was no difference in serum IFX concentrations in endoscopic, radiological, and laboratory activities. Only in the clinical evaluation there was a significant difference in the median serum IFX levels between patients in remission and disease activity, 5.63 [0.03-14.40] vs. 2.14 [0.32-10.54] (p=0.042). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">IFX serum concentrations during maintenance treatment were similar in patients with luminal CD in remission and general, endoscopic, radiological, and laboratory disease activity. Patients with clinically active disease had lower IFX concentrations than patients in remission. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn%27s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn's disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enfermedad+de+Crohn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enfermedad de Crohn</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enfermedad+inflamatoria+intestinal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enfermedad inflamatoria intestinal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monitoreo+terap%c3%a9utico+de+medicamentos%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monitoreo terapéutico de medicamentos</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nivel+m%c3%adnimo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nivel mínimo</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Therapeutic+drug+monitoring%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Therapeutic drug monitoring</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Trough+level%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Trough level</a></li></ul> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn+Disease%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn Disease/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cross-Sectional+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cross-Sectional Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Remission+Induction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Remission Induction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Young+Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Young Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Severity+of+Illness+Index%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Severity of Illness Index</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Monitoring%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Monitoring</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant15" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width: 40px; text-align: center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Little RD</b>, McKenzie J, Srinivasan A, Hilley P, Gilmore RB, Chee D, Sandhu M, Saitta D, Chow E, Thin L, Walker GJ, Moore GT, Lynch K, Andrews J, An YK, Bryant RV, Connor SJ, Garg M, Wright EK, Hold G, Segal JP, Boussioutas A, De Cruz P, Ward MG, Sparrow MP. Switching from Dose-Intensified intravenous to SubCutaneoUS infliximab in Inflammatory Bowel Disease (DISCUS-IBD): protocol for a multicentre randomised controlled trial. <em class='incite-journal-name' onclick='ShowInCiteJournal(3971);'>BMJ Open</em> 2024;<b>14</b>:e081787. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39032928' target='_blank'>39032928</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11261670' target='_blank'>PMC11261670</a> DOI: <a href='https://dx.doi.org/10.1136/bmjopen-2023-081787' target='_blank'>10.1136/bmjopen-2023-081787</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1136/bmjopen-2023-081787','39032928', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1136/bmjopen-2023-081787' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3971);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://app.penelope.ai/manuscript-check/q/bmjopen?_gl=1' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/24/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/23/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv16" value="10.1136/bmjopen-2023-081787" /> <div style="display: none" id="articleAbstract16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">INTRODUCTION</div><div class="abstract-content">A substantial proportion of patients with inflammatory bowel disease (IBD) on intravenous infliximab require dose intensification. Accessing additional intravenous infliximab is labour-intensive and expensive, depending on insurance and pharmaceutical reimbursement. Observational data suggest that subcutaneous infliximab may offer a convenient and safe alternative to maintain disease remission in patients requiring dose-intensified infliximab. A prospective, controlled trial is required to confirm that subcutaneous infliximab is as effective as dose-intensified intravenous infliximab, to identify predictors of disease flare and to establish the role of subcutaneous infliximab therapeutic drug monitoring. </div><div class="abstract-label">METHODS AND ANALYSIS</div><div class="abstract-content">The DISCUS-IBD trial is an investigator-initiated, prospective, multicentre, randomised, open-label non-inferiority study comparing the rate of disease flares in participants randomised to continue dose-intensified intravenous infliximab to those switched to subcutaneous infliximab after 48 weeks. Participants are adult patients with IBD in sustained corticosteroid-free remission on any regimen of dose-intensified infliximab up to a maximum of 10 mg/kg 4-weekly intravenously. Participants allocated to intravenous infliximab will continue infliximab at the same dose-intensified regimen they were receiving at study enrolment. Subcutaneous infliximab dosing will be stratified by prior intravenous infliximab dosing. Clinical (Harvey-Bradshaw Index, partial Mayo score), biochemical (C reactive protein, faecal calprotectin), pharmacokinetic (drug-level±antidrug antibodies) and qualitative data are collected 12-weekly until study conclusion at week 48. 13 sites across Australia will participate in recruitment to reach a calculated sample size of 120 participants. </div><div class="abstract-label">ETHICS AND DISSEMINATION</div><div class="abstract-content">Multisite ethics approval was obtained from the Health District Human Research Ethics Committee (HREC) at The Alfred Hospital under a National Mutual Acceptance (NMA) agreement (HREC/90559/Alfred-2022; Local Reference: Project 618/22, version 1.6, 2 March 2023). Findings will be reported at national and international gastroenterology meetings and published in peer-reviewed journals. DISCUS-IBD was prospectively registered with the Australian and New Zealand Clinical Trials Registry (ANZCTR) prior to commencing recruitment. </div><div class="abstract-label">TRIAL REGISTRATION NUMBER</div><div class="abstract-content">ACTRN12622001458729. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult+gastroenterology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult gastroenterology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+trials%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical trials</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Administration%2c+Intravenous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Administration, Intravenous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Australia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Australia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Monitoring%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Monitoring/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Injections%2c+Subcutaneous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Injections, Subcutaneous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Multicenter+Studies+as+Topic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Multicenter Studies as Topic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prospective Studies</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant16" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Celltrion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Celltrion</a></li></ul> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width: 40px; text-align: center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Bae JH</b>, Park JB, Baek JE, Hong SW, Park SH, Yang DH, Ye BD, Byeon JS, Myung SJ, Yang SK, Hwang SW. Effectiveness of Switching to Subcutaneous Infliximab in Ulcerative Colitis Patients Experiencing Intravenous Infliximab Failure. <em class='incite-journal-name' onclick='ShowInCiteJournal(10006);'>Gut Liver</em> 2024;<b>18</b>:667-676. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38835325' target='_blank'>38835325</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249938' target='_blank'>PMC11249938</a> DOI: <a href='https://dx.doi.org/10.5009/gnl230291' target='_blank'>10.5009/gnl230291</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.5009/gnl230291','38835325', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(17);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.5009/gnl230291' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10006);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/gnl/default.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/25/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/27/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/06/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" name="doiv" id="doiv17" value="10.5009/gnl230291" /> <div style="display: none" id="articleAbstract17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">Background/Aims</div><div class="abstract-content">Studies on elective switching to the subcutaneous (SC) formulation of infliximab revealed comparable efficacy and safety and higher infliximab level than those exhibited by intravenous (IV) infliximab. However, no studies have reported on the effectiveness of SC switching in ulcerative colitis (UC) patients who experienced IV infliximab failure during maintenance treatment. </div><div class="abstract-label">Methods</div><div class="abstract-content">This retrospective study included UC patients who had been switched to SC infliximab because of IV infliximab failure, between January 2021 and January 2023. Group A was defined as having clinically and biochemically active UC (secondary loss of response), and group B consisted of patients with stable symptoms but biochemically active UC. </div><div class="abstract-label">Results</div><div class="abstract-content">Twenty-three patients met the inclusion criteria: 15 in group A and eight in group B. The serum infliximab levels significantly increased after SC switching in both groups. The electively switched group also exhibited increased infliximab levels after SC switching. Patients in group A showed improved partial Mayo score with a significant decrease in fecal calprotectin and C-reactive protein after switching. In group B, the fecal calprotectin level significantly decreased without clinical relapse after switching. A high proportion of patients (≥80%) in both groups achieved clinical and/or biochemical responses at the last follow-up. During the follow-up period, only two patients in group A discontinued SC infliximab, and only one complained of severe injection site reaction. </div><div class="abstract-label">Conclusions</div><div class="abstract-content">In UC patients who experience IV infliximab failure during maintenance treatment, switching to SC infliximab may be a promising option because of better efficacy and safety. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Subcutaneous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Subcutaneous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ulcerative+colitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ulcerative colitis</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Injections%2c+Subcutaneous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Injections, Subcutaneous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Substitution%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Substitution/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Failure%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Failure</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Administration%2c+Intravenous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Administration, Intravenous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocyte+L1+Antigen+Complex%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocyte L1 Antigen Complex/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22C-Reactive+Protein%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">C-Reactive Protein/analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Feces%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Feces/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant17" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Research+Foundation+of+Korea%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Research Foundation of Korea</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ministry+of+Education%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ministry of Education</a></li></ul> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width: 40px; text-align: center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Schreiber S</b>, D'Haens G, Cummings F, Irving PM, Ye BD, Ben-Horin S, Kim DH, Jeong AL, Reinisch W. Switching from intravenous to subcutaneous infliximab maintenance therapy in inflammatory bowel disease: Post hoc longitudinal analysis of a randomized trial. <em class='incite-journal-name' onclick='ShowInCiteJournal(168749);'>Dig Liver Dis</em> 2024;<b>56</b>:1204-1212. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38365502' target='_blank'>38365502</a> DOI: <a href='https://dx.doi.org/10.1016/j.dld.2023.12.013' target='_blank'>10.1016/j.dld.2023.12.013</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.dld.2023.12.013','38365502', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.dld.2023.12.013' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168749);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/DLD' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/18/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv18" value="10.1016/j.dld.2023.12.013" /> <div style="display: none" id="articleAbstract18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Pharmacokinetic non-inferiority of subcutaneous (SC) to intravenous (IV) CT-P13 maintenance therapy was demonstrated in a randomized trial (NCT02883452). This post hoc analysis evaluated longitudinal clinical outcomes with the two infliximab treatment strategies. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Patients with Crohn's disease or ulcerative colitis received CT‑P13 IV loading doses (5 mg/kg; Week [W] 0 and W2) before randomization (1:1) to receive CT-P13 SC (body weight-based dosing every 2 weeks [Q2W]; W6-54; 'SC maintenance group') or CT‑P13 IV (5 mg/kg Q8W; W6-22) then CT-P13 SC (Q2W; W30-54; 'IV-to-SC switch group'). Paired W30/W54 patient-level data were analyzed. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Fifty-three (IV-to-SC switch) and fifty-nine (SC maintenance) patients were analyzed. Median trough serum CT-P13 concentrations were significantly higher at W54 versus W30 in the IV-to-SC switch group (20.4 versus 2.3 µg/mL; p < 0.00001), while remaining consistent in the SC maintenance group. Statistically significant improvements in pharmacokinetics, efficacy, fecal calprotectin levels, and quality of life were seen following switch to SC administration at W30 in the IV-to-SC switch group; safety findings were similar pre- and post-switch. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Formulation switching from IV to SC infliximab maintenance therapy was well tolerated and may provide additional clinical improvements. Findings require confirmation in larger prospective studies. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CT-P13%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CT-P13</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn%27s+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn's disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+necrosis+factor+inhibitor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor necrosis factor inhibitor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ulcerative+colitis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ulcerative colitis</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn+Disease%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn Disease/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Administration%2c+Intravenous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Administration, Intravenous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colitis%2c+Ulcerative%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colitis, Ulcerative/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/administration & dosage</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maintenance+Chemotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maintenance Chemotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Substitution%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Substitution</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Leukocyte+L1+Antigen+Complex%2fanalysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Leukocyte L1 Antigen Complex/analysis</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant18" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width: 40px; text-align: center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Alsoud D</b>, Moes DJAR, Wang Z, Soenen R, Layegh Z, Barclay M, Mizuno T, Minichmayr IK, Keizer RJ, Wicha SG, Wolbink G, Lambert J, Vermeire S, de Vries A, Papamichael K, Padullés-Zamora N, Dreesen E. Best Practice for Therapeutic Drug Monitoring of Infliximab: Position Statement from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. <em class='incite-journal-name' onclick='ShowInCiteJournal(22666);'>Ther Drug Monit</em> 2024;<b>46</b>:291-308. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38648666' target='_blank'>38648666</a> DOI: <a href='https://dx.doi.org/10.1097/ftd.0000000000001204' target='_blank'>10.1097/ftd.0000000000001204</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1097/ftd.0000000000001204','38648666', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(19);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1097/ftd.0000000000001204' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(22666);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/25/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv19" value="10.1097/ftd.0000000000001204" /> <div style="display: none" id="articleAbstract19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Infliximab, an anti-tumor necrosis factor monoclonal antibody, has revolutionized the pharmacological management of immune-mediated inflammatory diseases (IMIDs). This position statement critically reviews and examines existing data on therapeutic drug monitoring (TDM) of infliximab in patients with IMIDs. It provides a practical guide on implementing TDM in current clinical practices and outlines priority areas for future research. </div><div class="abstract-label">METHODS</div><div class="abstract-content">The endorsing TDM of Biologics and Pharmacometrics Committees of the International Association of TDM and Clinical Toxicology collaborated to create this position statement. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Accumulating data support the evidence for TDM of infliximab in the treatment of inflammatory bowel diseases, with limited investigation in other IMIDs. A universal approach to TDM may not fully realize the benefits of improving therapeutic outcomes. Patients at risk for increased infliximab clearance, particularly with a proactive strategy, stand to gain the most from TDM. Personalized exposure targets based on therapeutic goals, patient phenotype, and infliximab administration route are recommended. Rapid assays and home sampling strategies offer flexibility for point-of-care TDM. Ongoing studies on model-informed precision dosing in inflammatory bowel disease will help assess the additional value of precision dosing software tools. Patient education and empowerment, and electronic health record-integrated TDM solutions will facilitate routine TDM implementation. Although optimization of therapeutic effectiveness is a primary focus, the cost-reducing potential of TDM also merits consideration. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Successful implementation of TDM for infliximab necessitates interdisciplinary collaboration among clinicians, hospital pharmacists, and (quantitative) clinical pharmacologists to ensure an efficient research trajectory. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Monitoring%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Monitoring/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li></ul> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant19" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width: 40px; text-align: center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Serrano Díaz L</b>, Iniesta Navalón C, Gómez Espín R, Nicolás De Prado I, Bernal Morell E, Rentero Redondo L. Comparative effectiveness and drug survival of biosimilar infliximab CPT-13 vs. reference infliximab in inflammatory bowel disease: A retrospective cohort study. <em>GASTROENTEROLOGIA Y HEPATOLOGIA</em> 2024;<b>47</b>:553-561. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37597745' target='_blank'>37597745</a> DOI: <a href='https://dx.doi.org/10.1016/j.gastrohep.2023.08.004' target='_blank'>10.1016/j.gastrohep.2023.08.004</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.gastrohep.2023.08.004','37597745', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.gastrohep.2023.08.004' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/18/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/07/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/21/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv20" value="10.1016/j.gastrohep.2023.08.004" /> <div style="display: none" id="articleAbstract20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Studies have investigated the efficacy and safety of switching to the biosimilar infliximab (CT-P13) in patients with inflammatory bowel disease (IBD). However, there is limited research directly comparing the effectiveness, drug survival, and pharmacokinetic profiles of the reference infliximab (IFX) and CT-P13 in real clinical settings. </div><div class="abstract-label">OBJECTIVE</div><div class="abstract-content">To compare the effectiveness and drug survival of CPT-13 and reference IFX at weeks 26 and 52, and to determine the pharmacokinetic profiles and safety profile in real-world settings. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A retrospective observational cohort analysis was conducted at a single center. The study compared the proportion of patients achieving clinical remission and experiencing poor clinical outcomes at weeks 26 and 52. The drug survival rate of CT-P13 and reference infliximab was also assessed during the follow-up period. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">A total of 153 patients were included in the study, 39.2% receiving CPT-13 and 60.8% reference IFX. At week 26, clinical remission rates were 66.7% (CPT-13: 74.4% vs. reference IFX: 62.3%, p=0.178), and at week 52, they were 64% (CPT-13: 85.4% vs. reference IFX: 63.0%, p=0.012). Subgroup analysis with therapeutic drug monitoring (TDM) found no significant differences at week 26 (CPT-13: 74.4% vs. reference IFX: 58.8%, p=0.235) or at week 52 (CPT-13: 85.4% vs. reference IFX: 68.8%, p=0.153). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our study demonstrates comparable efficacy, drug survival, pharmacokinetic profiles, and incidence of immunogenicity between both drugs in a real clinical setting. Further studies with greater statistical power are needed to validate these findings. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-drug+antibody%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-drug antibody</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticuerpo+anti-infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticuerpo anti-infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosimilar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosimilar</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+survival%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug survival</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enfermedad+inflamatoria+intestinal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enfermedad inflamatoria intestinal</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Farmacocin%c3%a9tica%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Farmacocinética</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Persistencia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Persistencia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pharmacokinetic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pharmacokinetic</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Retrospective+Studies%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Retrospective Studies</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosimilar+Pharmaceuticals%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosimilar Pharmaceuticals/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biosimilar+Pharmaceuticals%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biosimilar Pharmaceuticals/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antibodies%2c+Monoclonal%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antibodies, Monoclonal/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Remission+Induction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Remission Induction</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant20" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width: 40px; text-align: center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Vermeire S</b>, Dubinsky MC, Rabizadeh S, Panetta JC, Spencer EA, Dreesen E, D'Haens G, Dervieux T, Laharie D. Forecasted infliximab concentrations during induction predict time to remission and sustained disease control of inflammatory bowel disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(6564);'>Clin Res Hepatol Gastroenterol</em> 2024;<b>48</b>:102374. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38750934' target='_blank'>38750934</a> DOI: <a href='https://dx.doi.org/10.1016/j.clinre.2024.102374' target='_blank'>10.1016/j.clinre.2024.102374</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.clinre.2024.102374','38750934', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(21);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://doi.org/10.1016/j.clinre.2024.102374' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(6564);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/clinre/default1.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 05/06/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/12/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 05/20/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv21" value="10.1016/j.clinre.2024.102374" /> <div style="display: none" id="articleAbstract21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Infliximab (IFX) exposure is established as a predictive factor of pharmacokinetic (PK) origin in inflammatory bowel disease (IBD), and expert consensus is to achieve adequate exposure during induction to achieve and sustain remission. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We retrospectively evaluated the performance of a Bayesian PK tool in IBD patients starting IFX. Trough IFX serum levels collected immediately before the third (at week 6) and fourth (at week 14) infusions were evaluated from 307 IBD patients (median age=17 years, 50 % females, 83 % with Crohn's disease). Forecasted IFX concentration at the fourth infusion were estimated using serum IFX, antibodies to IFX, albumin and weight determined immediately before the third infusion using population PK calculator with Bayesian prior. The outcome variable was a clinical & biochemical remission status achieved (CRP levels below 3 mg/L in presence of clinical remission). Statistics consisted of Kaplan Meier analysis with calculation of Hazard ratio (HR), and logistic regression. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">IFX concentration above 15 µg/mL immediately before the third infusion associated with shorter time to clinical & biochemical remission than concentration below 15 µg/mL without reaching significance (163±14 days vs 200±16 days, respectively; p=0.052). However, using PK parameters at the third infusion, forecasted IFX concentrations above 10 µg/mL immediately before the fourth infusion were significantly associated with a higher rate (HR=1.6 95 %CI: 1.1 to 2.1 p<0.01) and shorter time to remission (148±18 days vs 200±13 days p<0.01). In the presence of IFX concentration above 15 µg/mL at the third infusion, there was a significant 2.5-fold higher likelihood of sustained clinical & biochemical remission status during maintenance as compared to IFX concentrations below 15 µg/mL (p<0.01). Forecasted IFX level above 10 µg/mL at fourth infusion associated with significantly 3.9-fold higher likelihood of clinical & biochemical remission as compared to forecasted IFX concentrations below 10 µg/mL (p<0.01). </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">These data further support that optimized IFX concentrations during induction are associated with enhanced disease control in IBD. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Therapeutic+drug+monitoring%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Therapeutic drug monitoring</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Crohn+Disease%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Crohn Disease/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li></ul> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant21" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width: 40px; text-align: center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Roblin X</b>, Nancey S, Papamichael K, Duru G, Flamand M, Kwiatek S, Cheifetz A, Fabien N, Barrau M, Paul S. Higher Serum Infliximab Concentrations Following Subcutaneous Dosing are Associated with Deep Remission in Patients with Inflammatory Bowel Disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(13594);'>J Crohns Colitis</em> 2024;<b>18</b>:679-685. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37934041' target='_blank'>37934041</a> DOI: <a href='https://dx.doi.org/10.1093/ecco-jcc/jjad188' target='_blank'>10.1093/ecco-jcc/jjad188</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1093%2fecco-jcc%2fjjad188%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1093%2fecco-jcc%2fjjad188')">Impact Index Per Article: 4.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/ecco-jcc/jjad188','37934041', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(22);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/ecco-jcc/jjad188' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13594);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/ecco-jcc' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/14/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/08/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv22" value="10.1093/ecco-jcc/jjad188" /> <div style="display: none" id="articleAbstract22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The relationship between subcutaneous infliximab [SC-IFX] concentrations and favourable therapeutic outcomes in patients with Crohn's disease [CD] and ulcerative colitis [UC] remains elusive. </div><div class="abstract-label">PATIENTS AND METHODS</div><div class="abstract-content">This cross-sectional study included consecutive adult patients with inflammatory bowel disease [IBD] treated with SC-IFX at a maintenance dose of 120 mg/2 weeks. Investigated therapeutic outcomes included sustained clinical remission; composite clinical and biomarker remission [clinical remission and C-reactive protein <5 mg/L]; biochemical remission [faecal calprotectin <250 µg/g]; and deep remission [clinical, biological, and biochemical remission]. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Of 91 patients identified, 71 qualified for inclusion in the study [70% with CD; 27% with concomitant immunomodulators]. At the time of drug concentration measurement [median 13.5 months after switch], 55 [77%] patients had sustained clinical remission; n = 44 [62%] composite clinical and biomarker remission; n = 40 [56%] biochemical remission; and n = 31 [43%] deep remission. The mean SC-IFX concentrations were significantly higher in patients with sustained clinical remission [p = 0.014]; composite clinical and biomarker remission [p = 0.003]; biochemical remission [p < 0.001]; and deep remission [p < 0.001] compared to patients without having these outcomes. In multivariate analysis, SC-IFX concentration was the only factor independently associated with sustained clinical remission (odds ratio [OR]: 4.7, 95% confidence interval [CI]: 3.1-12.2, p = 0.005); clinical and biomarker remission [OR: 9.21, 95% CI: 6.09-18.7, p = 0.006]; biochemical remission [OR: 37, 95% CI: 14-39.3, p < 0.001]; and deep remission [OR: 29, 95% CI: 15.7-37.4, p < 0.001]. The optimal SC-IFX concentration cut-off associated with deep remission based on ROC analysis was 20 µg/mL [sensitivity: 0.91, specificity: 0.80, accuracy: 0.85]. Combination with an immunomodulator failed to improve SC-IFX pharmacokinetics. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Higher SC-IFX concentrations are associated with higher rates of favourable therapeutic outcomes in IBD patients. Serum SC-IFX concentrations >20 µg/mL were significantly associated with deep remission. </div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords22" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22IFX+levels%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">IFX levels</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22remission%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">remission</a></li><li><a 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Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 months of maintenance treatment with infliximab. <em class='incite-journal-name' onclick='ShowInCiteJournal(168749);'>Dig Liver Dis</em> 2024;<b>56</b>:737-743. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37980274' target='_blank'>37980274</a> DOI: <a href='https://dx.doi.org/10.1016/j.dld.2023.10.027' target='_blank'>10.1016/j.dld.2023.10.027</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.dld.2023.10.027%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.dld.2023.10.027')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.dld.2023.10.027','37980274', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(23);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.dld.2023.10.027' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(168749);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/DLD' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/20/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv23" value="10.1016/j.dld.2023.10.027" /> <div style="display: none" id="articleAbstract23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The emergence of new treatments the inflammatory bowel diseases (IBD) raised questions regarding the role of older agents, namely thiopurines. </div><div class="abstract-label">AIMS</div><div class="abstract-content">To clarify the benefits of combination treatment with thiopurines on Crohn's disease (CD) patients in the maintenance phase of infliximab. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In this analysis of the 2-year prospective multicentric DIRECT study, patients were assessed in terms of clinical activity, faecal calprotectin (FC), C-reactive protein (CRP), and infliximab pharmacokinetics. A composite outcome based on clinical- and drug-related items was used to define treatment failure. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The study included 172 patients; of these, 35.5 % were treated with combination treatment. Overall, 18 % of patients achieved the composite outcome, without statistically significant differences between patients on monotherapy and on combination treatment (21.6% vs 11.5 %, p = 0.098). Median CRP, FC, and infliximab pharmacokinetic parameters were similar in both groups. However, in the sub-analysis by infliximab treatment duration, in patients treated for less than 12 months, the composite outcome was reached in fewer patients in the combination group than in the monotherapy group (7.1% vs 47.1 %, p = 0.021). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">In CD patients in maintenance treatment with infliximab, combination treatment does not seem to have benefits over infliximab monotherapy beyond 12 months of treatment duration. </div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Combination+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Combination therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Thiopurines%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Thiopurines</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mercaptopurine%2fadministration+%26amp%3b+dosage%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mercaptopurine/administration & dosage</a></li></ul> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant23" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width: 40px; text-align: center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Clemente-Bautista S</b>, Trocóniz IF, Segarra-Cantón Ó, Salvador-Marín S, Parramón-Teixidó CJ, Álvarez-Beltrán M, López-Fernández LA, Colom H, Cabañas-Poy MJ, Gorgas-Torner MQ, Miarons M. The Effect of Polymorphisms and Other Biomarkers on Infliximab Exposure in Paediatric Inflammatory Bowel Disease: Development of a Population Pharmacokinetic Model. <em class='incite-journal-name' onclick='ShowInCiteJournal(18806);'>Paediatr Drugs</em> 2024;<b>26</b>:331-346. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38507036' target='_blank'>38507036</a> DOI: <a href='https://dx.doi.org/10.1007/s40272-024-00621-1' target='_blank'>10.1007/s40272-024-00621-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s40272-024-00621-1','38507036', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(24);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s40272-024-00621-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(18806);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/pdda' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/20/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/22/2024]</span></span> </div> <input type="hidden" name="doiv" id="doiv24" value="10.1007/s40272-024-00621-1" /> <div style="display: none" id="articleAbstract24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Therapeutic drug monitoring (TDM) of infliximab has been shown to be a effective strategy for inflammatory bowel disease (IBD). Population pharmacokinetic (PopPK) modeling can predict trough concentrations for individualized dosing. </div><div class="abstract-label">OBJECTIVE</div><div class="abstract-content">The aim of this study was to develop a PopPK model of infliximab in a paediatric population with IBD, assessing the effect of single nucleotide polymorphisms (SNPs) and other biomarkers on infliximab clearance. </div><div class="abstract-label">METHODS</div><div class="abstract-content">This observational and ambispective single-centre study was conducted in paediatric patients with IBD treated with infliximab between July 2016 and July 2022 in the Paediatric Gastroenterology Service of the Hospital Universitari Vall d'Hebron (HUVH) (Spain). Demographic, clinical, and analytical variables were collected. Twenty SNPs potentially associated with variations in the response to infliximab plasma concentrations were analysed. infliximab serum concentrations and antibodies to infliximab (ATI) were determined by ELISA. PopPK modelling was performed using nonlinear mixed-effects analysis (NONMEM). </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Thirty patients (21 males) were included. The median age (range) at the start of infliximab treatment was 13 years (16 months to 16 years). A total of 190 samples were obtained for model development (49 [25.8%] during the induction phase). The pharmacokinetics (PK) of infliximab were described using a two-compartment model. Weight, erythrocyte sedimentation rate (ESR), faecal calprotectin (FC), and the SNP rs1048610 (ADAM17) showed statistical significance for clearance (CL), and albumin for inter-compartmental clearance (Q). Estimates of CL1 (genotype 1-AA), CL2 (genotype 2-AG), CL3 (genotype 3-GG), Q, Vc, and Vp (central and peripheral distribution volumes) were 0.0066 L/h/46.4 kg, 0.0055 L/h/46.4 kg, 0.0081 L/h/46.4 kg, 0.0029 L/h/46.4 kg, 0.6750 L/46.4 kg, and 1.19 L/46.4 kg, respectively. The interindividual variability (IIV) estimates for clearance, Vc, and Vp were 19.33, 16.42, and 36.02%, respectively. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">A popPK model utilising weight, albumin, FC, ESR, and the SNP rs1048610 accurately predicted infliximab trough concentrations in children with IBD. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infliximab%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infliximab/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adolescent%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adolescent</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Polymorphism%2c+Single+Nucleotide%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Polymorphism, Single Nucleotide</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Child%2c+Preschool%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Child, Preschool</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Inflammatory+Bowel+Diseases%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Inflammatory Bowel Diseases/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2fblood%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers/blood</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Monitoring%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Monitoring/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Infant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Infant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2fpharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastrointestinal+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastrointestinal Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Models%2c+Biological%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Models, Biological</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Spain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Spain</a></li></ul> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleGrant24" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float: right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width: 40px; text-align: center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Wieringa JW</b>, Kruizinga MD, Driessen GJA, van der Woude CJ, Julsgaard M. Validation of the Pharmacokinetic Model for Anti-TNFα Clearance in Infants Exposed to Anti-TNFα During Pregnancy. <em class='incite-journal-name' onclick='ShowInCiteJournal(13594);'>J Crohns Colitis</em> 2024;<b>18</b>:506-515. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37823516' target='_blank'>37823516</a> DOI: <a href='https://dx.doi.org/10.1093/ecco-jcc/jjad172' target='_blank'>10.1093/ecco-jcc/jjad172</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1093/ecco-jcc/jjad172','37823516', 'Infliximab/pharmacokinetics')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(25);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(25);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1093/ecco-jcc/jjad172' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13594);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://mc.manuscriptcentral.com/ecco-jcc' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/13/2023]</span></span> </div> <input type="hidden" name="doiv" id="doiv25" value="10.1093/ecco-jcc/jjad172" /> <div style="display: none" id="articleAbstract25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Abstract</b> <div class="abstract-label">BACKGROUND AND AIMS</div><div class="abstract-content">The ECCO guideline recommends postponing live attenuated vaccines in infants exposed to anti-tumour necrosis factor alpha [anti-TNFα] in utero until drug clearance. The aim was to validate the predictive performance of the anti-TNFα clearance model. </div><div class="abstract-label">METHODS</div><div class="abstract-content">Newborns and data for anti-TNFα concentrations from the prospective PETIT cohort were included. The anti-TNFα clearance model was used to predict all measured concentrations in the PETIT cohort, based on the measured cord blood concentration and the mean population clearance described in the model. Bayesian maximum a posteriori optimization was used to estimate the use of drug monitoring. Predictive capability and drug monitoring were assessed through mean absolute error [MAE], root mean squared prediction error, and limits of agreement according to Bland and Altman. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Observed drug concentrations after birth were within the 80% prediction interval in 94% of adalimumab samples and 93% of infliximab samples. The anti-TNFα clearance model accurately predicted the concentration at 6 months after birth with an MAE of 0.03 µg/mL [SD 0.03] for adalimumab and 0.11 µg/mL [SD 0.18] for infliximab based on cord blood concentrations. Addition of an additional sample between 1 and 4 months after birth improved the predictive accuracy for infliximab (MAE 0.05 [SD 0.09]) but not for adalimumab. Guidance for use in clinical practice was formulated. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">The validity of the anti-TNFα clearance model is high, and hence can be used to guide clinicians regarding the timing of live vaccines in infants exposed to adalimumab or infliximab in utero. </div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleKeywords25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anti-tumour+necrosis+factor+alpha%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anti-tumour necrosis factor alpha</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22clearance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">clearance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22inflammatory+bowel+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">inflammatory bowel disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pharmacokinetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pharmacokinetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pregnancy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pregnancy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22pregnancy+outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">pregnancy outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22vaccination%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">vaccination</a></li></ul> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float: right;">Collapse</a> </div> <div style="display: none" id="articleMesh25" class="article-abstract"> <b style="display: block; padding-bottom: 0.5rem; font-size: 1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a 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src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_pcEditArticleControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_pcEditArticleControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_298765222" type="text/javascript">  </script> <div id="RootHolder_userIndexComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:400px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Article Influence Index</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle2">Article Influence Index</span></b> </p> <p> Total Citations in Crossref ÷ Total Articles = <span id="RootHolder_userIndexComputePopup_InfluenceIndexTitle3">Article Influence Index</span><sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="RootHolder_userIndexComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_userIndexComputePopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_userIndexComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue 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class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-activeTab dxtc-lead"><a class="dxtc-link"><span class="dx-vam">Export Article Detail</span></a></li><li class="dxtc-spacer"> </li><li class="dxtc-tab dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_SearchTermText1">Infliximab/pharmacokinetics (59 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:5px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_1662381219" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ExportDetailEndIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportDetailEndIndex')" value="59" type="text" /></td> </tr> </table><script id="dxss_616434442" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$selectDetailSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_selectDetailSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_1167331127" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_54524200" type="text/javascript">  </script><script id="dxss_1678130197" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" style="font-weight:bold;">JCR Year:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_VI" type="hidden" value="2023" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear')" value="2023" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$JCRYear$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_JCRYear_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2023</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2022</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">2021</td> </tr> </table> </div></td> </tr> </table><script id="dxss_830317689" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_167955898" type="text/javascript">  </script><script id="dxss_2013408041" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:5px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$DetailFileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1062639383" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_104403608" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_DetailFileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1973673553" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_6" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLTSys dxflItemSys dxflCheckBoxWithTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" style="font-weight:bold;">Record Content:</label></td> </tr><tr> <td class="dxflNestedControlCell_MetropolisBlue"> <table> <tr> <td style="vertical-align: middle; padding: 5px;"> <table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields" style="color:#BD4100;"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_cbSelectAllFields_S" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$cbSelectAllFields" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label>Select All Fields</label></td> </tr> </table><script id="dxss_1176833720" type="text/javascript">  </script> </td> </tr> <tr> <td style="padding: 5px;"> <table class="dxeCheckBoxList_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields" style="width:100%;border-collapse:separate;"> <tr> <td class="dxe"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields" /><table style="width:100%;"> <tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB0_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB0" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Author(s)</label></td> </tr> </table><script id="dxss_771536870" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB1_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB1" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Title</label></td> </tr> </table><script id="dxss_1086331335" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB2_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB2" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Keywords</label></td> </tr> </table><script id="dxss_1308541020" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB3_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB3" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">MESH Headings</label></td> </tr> </table><script id="dxss_896786043" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB4_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB4" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Journal Title</label></td> </tr> </table><script id="dxss_450242410" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB5_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB5" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Year</label></td> </tr> </table><script id="dxss_765036875" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB6_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB6" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Article Type</label></td> </tr> </table><script id="dxss_1629835480" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB7_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB7" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Language</label></td> </tr> </table><script id="dxss_1218080503" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB8_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB8" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Published Date</label></td> </tr> </table><script id="dxss_1428514578" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB9_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB9" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author</label></td> </tr> </table><script id="dxss_1113720113" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB10_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB10" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">First Author’s Affiliations</label></td> </tr> </table><script id="dxss_310841941" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB11_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB11" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author</label></td> </tr> </table><script id="dxss_1301541094" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB12_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB12" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Corresponding Author’s Affiliations</label></td> </tr> </table><script id="dxss_675718561" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB13_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB13" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Email</label></td> </tr> </table><script id="dxss_2006865700" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB14_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB14" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">All Authors's Affiliations</label></td> </tr> </table><script id="dxss_1204905793" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB15_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB15" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Grant</label></td> </tr> </table><script id="dxss_407477242" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB16_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB16" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">ISSN</label></td> </tr> </table><script id="dxss_218345291" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB17_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB17" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Publisher</label></td> </tr> </table><script id="dxss_1394037744" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB18_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB18" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexing / Abstracting</label></td> </tr> </table><script id="dxss_319681069" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB19_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB19" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Factor</label></td> </tr> </table><script id="dxss_1292701966" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB20_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB20" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">JCR Quartile</label></td> </tr> </table><script id="dxss_1844280938" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB21_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB21" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Impact Index Per Article</label></td> </tr> </table><script id="dxss_838303323" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB22_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB22" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Category</label></td> </tr> </table><script id="dxss_1464125856" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB23_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB23" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Times Cited in RCA</label></td> </tr> </table><script id="dxss_148257179" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB24_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB24" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Peer-Reviewed Journal</label></td> </tr> </table><script id="dxss_950217086" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB25_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB25" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Open Access</label></td> </tr> </table><script id="dxss_1732367175" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB26_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB26" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">DOI</label></td> </tr> </table><script id="dxss_1936777588" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB27_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB27" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">PMID</label></td> </tr> </table><script id="dxss_745806673" type="text/javascript">  </script></td> </tr><tr> <td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB28_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB28" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Citation</label></td> </tr> </table><script id="dxss_1835441810" type="text/javascript">  </script></td><td><table class="dxeBase_MetropolisBlue dxeTAR" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29"> <tr> <td class="dxichCellSys"><span class="dxWeb_edtCheckBoxUnchecked_MetropolisBlue dxICheckBox_MetropolisBlue dxichSys dx-not-acc"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ArticleFieldExportFields_RB29_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportDetailPopupFormLayout$ArticleFieldExportFields$RB29" value="I" type="text" readonly="readonly" style="border-width:0;width:0;height:0;padding:0;margin:0;position:relative;background-color:transparent;display:block;" /></span></td><td class="dxichTextCellSys"><label class="dx-wrap">Indexed in RCA</label></td> </tr> </table><script id="dxss_847142451" type="text/javascript">  </script></td><td></td><td></td> </tr> </table></td> </tr> </table><script id="dxss_1169734383" type="text/javascript">  </script> </td> </tr> </table> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_7" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportDetailPopupFormLayout_ExportedDetailFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_1198171345" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_1960175520" type="text/javascript">  </script> </div> </div><div style="display:none;"> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0_Cap" class="dxDefaultCursor dxflCaption_MetropolisBlue" style="font-weight:bold;">Searched Name:</span></td><td class="dxflNestedControlCell_MetropolisBlue"> <span class="dxeBase_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_SearchTermText2">Infliximab/pharmacokinetics (59 results from Reference Citation Analysis)</span> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight: bold">Article Number From</span> </td> <td>   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td>  to   </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="59" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> <td>  </td> <td>(No more than 600 records at a time.) </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:10px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" style="font-weight:bold;">Indexing:</label></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource" style="width:200px;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_VI" type="hidden" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource')" value="Please Select" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100" class="dxeButton dxeButtonEditButton_MetropolisBlue dxeButtonEditClearButton_MetropolisBlue" onmousedown="ASPx.BEClear('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="display:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-100Img" class="dxEditors_edtClear_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="x" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$selectSource$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_selectSource_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr> <td></td> </tr> </table> </div></td> </tr> </table><script id="dxss_2046065225" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_1926633208" type="text/javascript">  </script><script id="dxss_228619664" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_4" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_5" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" 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All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:455px;width:420px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:14pt;font-style:italic;border-bottom-style:Solid;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Welcome to Reference Citation Analysis</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1691100642" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>