Spotlight on Renal Denervation

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</div> <script src="/web/20140305101404js_/http://www.healio.com/sitecore modules/web/web forms for marketers/scripts/jquery.js" type="text/javascript"></script> <script src="/web/20140305101404js_/http://www.healio.com/sitecore modules/web/web forms for marketers/scripts/jquery-ui.min.js" type="text/javascript"></script> <script src="/web/20140305101404js_/http://www.healio.com/sitecore modules/web/web forms for marketers/scripts/jquery-ui-i18n.js" type="text/javascript"></script> <script src="/web/20140305101404js_/http://www.healio.com/sitecore modules/web/web forms for marketers/scripts/json2.min.js" type="text/javascript"></script> <script src="/web/20140305101404js_/http://www.healio.com/sitecore modules/web/web forms for marketers/scripts/head.load.min.js" type="text/javascript"></script> <script src="/web/20140305101404js_/http://www.healio.com/sitecore modules/web/web forms for marketers/scripts/sc.webform.js?v=17072012" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ $scw(document).ready(function() {$scw('#form_83EA09863C65413F858E12608727AA3B').webform({formId:"{83EA0986-3C65-413F-858E-12608727AA3B}", pageId:"{70133EC4-AD1A-4C2D-B9AC-70602A481064}", eventCountId:"greetingContainer2_ctlLanding_form_83EA09863C65413F858E12608727AA3B_form_83EA09863C65413F858E12608727AA3B_eventcount", tracking : true})});//]]> </script> <script src="https://web.archive.org/web/20140305101404js_/http://ajax.aspnetcdn.com/ajax/4.5.1/1/MicrosoftAjax.js" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ (window.Sys && Sys._Application && Sys.Observer)||document.write('<script type="text/javascript" src="/ScriptResource.axd?d=kbHUNs7g6HKcCEASU9GEYTX1lEJcrOvm4PphGQdxYIRFSbEQftASnygvl15Lp42EI_jtchT9qOJvJuZeE_E7qQjFcNMZlQc3gYHv661MpQHhiy8Eha9afY0PVJ9fTerwJ_mtyYGjVZfMGx-TJ9VPzwRB_xs1&t=ca758f3"><\/script>');//]]> </script> <div id="fb-root"> </div>  <div id="wrap">  <div id="header">  <div class="col1">  <div class="leaderboard">  <div id="div-gpt-ad-1369169134306-4"></div> </div>  <p class="survey">  <a href="https://web.archive.org/web/20140305101404/http://healio.wufoo.com/forms/z7x3x5/" onclick="window.open(this.href, null, 'height=768, width=680, toolbar=0, location=0, status=1, scrollbars=1, resizable=1'); return false" rel="nofollow">Tell us</a> what you think about Healio</p> <ul id="ulTopNav" class="utility-nav"> <li class="nw"><a href="/web/20140305101404/http://www.healio.com/footer/account-information/my-account/newswires"> enewsletter Alerts</a></li> <li class="rss"><a href="/web/20140305101404/http://www.healio.com/rss">RSS Feeds</a></li> </ul>  <ul id="brand"> <li class="specialty-link-healio"> <h1 class="specialty-healio"><a href="/web/20140305101404/http://www.healio.com/">Healio</a></h1> <h1 class="specialty-sub"><a href="/web/20140305101404/http://www.healio.com/cardiology">Cardiology</a></h1> </li> <li class="logo"> <a href="/web/20140305101404/http://www.healio.com/cardiology"><img alt="" height="57" width="415" src="/web/20140305101404im_/http://www.healio.com/cardiology/~/media/21E6818909654561A6C17E515F832421.ashx"/></a> </li> </ul>  </div>   <div class="col2" id="greetingcontainer"> <div id="greetingContainer2_divPartialReg"> <style type="text/css"> .linkNav { background: #f0f0f0; border: 1px solid #bdbdbd; color: #527091; padding: 5px; padding-left: 20px; } .linkNav a { color: #527091; text-decoration: none; cursor: pointer; } .ctaTextArea { position: absolute; width: 220px; bottom: 8px; left: 0px; font-weight: bold; text-align: center; } .ctaRegLink { position: relative; } </style> <script type="text/javascript"> //JS here $j(document).ready(function () { var showCta = false; var currentCTA = ''; if(showCta){ $j(".ctaImageLinkWrapper").click(function (event) { _gaq.push(['_trackEvent', 'Registration Process', 'CTA Click', currentCTA]); }); _gaq.push(['_trackEvent', 'Registration Process', 'CTA Load', currentCTA]); } }); </script> </div> <div id="greetingContainer2_divVisitor"> <style type="text/css"> .ctaShortRegForm { border: 2px solid #74b64a; background: #e7f3e0; } .shortRegTitle { background: #74b64a; color: White; padding: 3px; font-weight: bold; font-size: larger; } .shortRegForm { padding: 3px; position: relative; } .linkNav { background: #f0f0f0; border: 1px solid #bdbdbd; color: #527091; padding: 5px; padding-left: 20px; } .linkNav a { color: #527091; text-decoration: none; cursor: pointer; } /*Form Styling*/ .scfSectionContent .healioregform .scfValidator { position: absolute; top: 25px; left: 0; color: Red; width: 150px; height: 30px; overflow: hidden; background: #e7f3e0; } .scfSectionContent .healioregform:first-child .scfValidator { position: absolute; top: 55px; left: 0; color: Red; width: 150px; height: 30px; overflow: hidden; background: #e7f3e0; } .scfValidationSummary { position: absolute; top: 60px; left: 3px; color: Red; width: 150px; height: 30px; overflow: hidden; background: #e7f3e0; } .healioregform input.scfSingleLineTextBox { width: 150px !important; border: 1px solid #ccc !important; } .healioregform .scfSingleLineTextLabel { width: 30px !important; padding-bottom: 10px !important; padding-left: 10px !important; } .scfSubmitButtonBorder { text-align: right !important; } .healioregform { position: relative; clear: both; } .healioregform .scfRequired { position: absolute; left: 0px; width: 5px !important; } .ctaShortRegForm { height: 115px; } .scfSubmitButtonBorder { text-align: right !important; } </style> <script type="text/javascript"> //JS here $j(document).ready(function () { $j(".scfSubmitButton").attr("disabled","disabled"); var showModal = false; var smcookie = $j.cookie('hregshowthanks'); if(smcookie != null){ if(smcookie.length>0){ showModal = (smcookie == 'true'); } } var ctaValue = 'landingcta3'; if ($j.cookie('hregctaval') != null) { if ($j.cookie('hregctaval').length>0) { ctaValue = $j.cookie('hregctaval'); } } 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href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation"><img src="/web/20140305101404im_/http://www.healio.com/~/media/Images/Resource Centers/Cardiology/Spotlight on Renal Denervation/SpotlightonRenalDenervationl_488x63.jpg" alt="" border="0"/></a> <p><strong style="margin: 0px; padding: 0px; font-size: 14px; vertical-align: baseline; border: 0px none; outline: 0px none; background-color: #ffffff; color: #444444; font-family: arial,helvetica,sans-serif; line-height: 20px;">Welcome to the Healio.com/Cardiology Spotlight on Renal Denervation</strong>. This collection of articles includes recent news and research related to renal denervation, along with expert perspective and commentary on the impact of these developments on your clinical practice.</p> <h2></h2> <div class="resource-wrap"><br/> <h3>SYMPLICITY HTN-3 fails to meet primary efficacy endpoint</h3>  <div class="mug right"> <a href="https://web.archive.org/web/20140305101404/http://www.healio.com/cardiology/chd-prevention/news/online/%7B3d45415c-421b-4ad0-86d6-0826232d4878%7D/fda-advisory-panel-recommends-approval-for-dapagliflozin"><img height="90" width="70" src="/web/20140305101404im_/http://www.healio.com/~/media/Images/Mugs/Cardiology/B/Bhatt_Deepak_70x90.gif" alt="Deepak L. Bhatt, MD, MPH"/></a> <p class="name"><strong>Deepak L. Bhatt</strong></p></div>  <p>Medtronic has announced today that the SYMPLICITY HTN-3 trial, the pivotal study evaluating the company鈥檚 Symplicity renal denervation catheter in patients with treatment-resistant hypertension, has failed to meet its primary efficacy endpoint of change in office systolic BP from baseline to 6 months.</p> <p>The trial did, however, meet its primary safety endpoint, and the Data Safety Monitoring Board concluded there were no safety concerns in the study. <a href="https://web.archive.org/web/20140305101404/http://www.healio.com/cardiology/intervention/news/online/%7Bb65037e6-d8fb-467a-9242-f0825f43422f%7D/symplicity-htn-3-fails-to-meet-primary-efficacy-endpoint">More »</a></p></div> <br/> </div> <div id="results" class="module-box rc"> <h3>Featured News</h3> <ul class="content-list"> <li class="kicker"> <span class="perspective-flag">Perspective</span> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/symplicity-htn-3-fails-to-meet-primary-efficacy-endpoint"> SYMPLICITY HTN-3 fails to meet primary efficacy endpoint</a></h4> </li> <li class="meta-info"> January 9, 2014</li> <li class="meta-info"> Medtronic has announced today that the SYMPLICITY HTN-3 trial, the pivotal study evaluating the company’s Symplicity renal denervation catheter in...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/symplicity-htn-3-fails-to-meet-primary-efficacy-endpoint" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> <span class="dept">Commentary</span> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/a-year-of-excitement-and-challenges"> A year of excitement and challenges</a></h4> </li> <li class="meta-info"> Cardiology Today, January 2014<br/><i>Carl J. Pepine, MD</i></li> <li class="meta-info"> Progress was made on a number of exciting new therapies in 2013.<br/>First and foremost is the enthusiasm created by renal denervation for treatment-resistant...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/a-year-of-excitement-and-challenges" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/multi-electrode-renal-denervation-catheter-approved-in-europe-australia"> Multi-electrode renal denervation catheter approved in Europe, Australia</a></h4> </li> <li class="meta-info"> December 17, 2013</li> <li class="meta-info"> Medtronic has announced that its 4F multi-electrode Symplicity Spyral catheter and Symplicity G3 radio frequency generator have received a CE mark in...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/multi-electrode-renal-denervation-catheter-approved-in-europe-australia" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/st-jude-medical-stops-enrollment-for-renal-denervation-trial"> St. Jude Medical stops enrollment for renal denervation trial</a></h4> </li> <li class="meta-info"> December 13, 2013</li> <li class="meta-info"> St. Jude Medical has halted enrollment of the EnligHTN IV trial, which was to be the first US clinical trial for its EnligHTN renal denervation system.<br/>...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/st-jude-medical-stops-enrollment-for-renal-denervation-trial" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/valentin-fuster-md-renal-denervation-cardiac-education-focus-of-symposium"> Valentin Fuster, MD: Renal denervation, cardiac education focus of symposium</a></h4> </li> <li class="meta-info"> December 13, 2013</li> <li class="meta-info"> New applications for renal denervation and educational interventions for children about dietary behavior and physical activity will be among the biggest...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/valentin-fuster-md-renal-denervation-cardiac-education-focus-of-symposium" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> <span class="dept">In the Journals</span> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/renal-denervation-continues-to-show-promise-in-resistant-hypertension"> Renal denervation continues to show promise in resistant hypertension</a></h4> </li> <li class="meta-info"> December 5, 2013</li> <li class="meta-info"> Renal denervation was associated with improvements in systolic BP and heart rate in a cohort of patients with resistant hypertension, according to recent...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/renal-denervation-continues-to-show-promise-in-resistant-hypertension" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> <span class="dept">Meeting News Coverage</span> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/renal-denervation-preserved-renal-function-in-resistant-hypertension-ckd"> Renal denervation preserved renal function in resistant hypertension, CKD</a></h4> </li> <li class="meta-info"> November 21, 2013</li> <li class="meta-info"> DALLAS — Pilot study data have shown that in addition to reducing BP, catheter-based renal denervation may slow and even halt the decline of renal...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/renal-denervation-preserved-renal-function-in-resistant-hypertension-ckd" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/first-renal-denervation-trial-in-us-patients-with-moderate-hypertension-underway"> First renal denervation trial in US patients with moderate hypertension underway</a></h4> </li> <li class="meta-info"> November 11, 2013</li> <li class="meta-info"> SYMPLICITY HTN-4, the first trial to assess renal denervation for the treatment of moderate uncontrolled hypertension in US patients, is underway,...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/first-renal-denervation-trial-in-us-patients-with-moderate-hypertension-underway" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> <span class="dept">In the Journals</span> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/renal-denervation-found-less-efficacious-in-patients-with-accessory-renal-arteries"> Renal denervation found less efficacious in patients with accessory renal arteries</a></h4> </li> <li class="meta-info"> October 22, 2013</li> <li class="meta-info"> Individuals with resistant hypertension and accessory renal arteries who underwent catheter-based renal sympathetic denervation experienced less...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/renal-denervation-found-less-efficacious-in-patients-with-accessory-renal-arteries" class="jump-link inline">More <span>»</span></a></li> </ul> <ul class="content-list"> <li class="kicker"> </li> <li> <h4> <a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/next-generation-renal-denervation-system-receives-ce-mark"> Next-generation renal denervation system receives CE mark</a></h4> </li> <li class="meta-info"> August 30, 2013</li> <li class="meta-info"> St. Jude Medical announced that it has received a CE mark approval for its next-generation renal denervation system for patients with uncontrolled...<a href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/next-generation-renal-denervation-system-receives-ce-mark" class="jump-link inline">More <span>»</span></a></li> </ul>   <div 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id="layout_0_ctl01_sidebarbelowad_0_imgMugShot" src="/web/20140305101404im_/http://www.healio.com/~/media/Images/Mugs/Cardiology/R/RochaSingh_KrishnaJ.gif" style="height:100px;width:75px;"/></a> </li> <li class="perspective-title-first">Krishna J. Rocha-Singh, MD, FACC, FAHA</li> <li class="first"> <a id="layout_0_ctl01_sidebarbelowad_0_hlExcerpt" href="/web/20140305101404/http://www.healio.com/cardiology/spotlight-on-renal-denervation/symplicity-htn-3-fails-to-meet-primary-efficacy-endpoint">Right now we know only what is in the Medtronic press release, so everything is conjecture at this point. 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