Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment | School of Optometry & Vision Science

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aem-GridColumn--offset--default--0"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="column-layout uds-component padded-left padded-right padded-left__small--0 padded-right__small--0 aem-GridColumn aem-GridColumn--default--12"> <span data-component_type="column-layout" data-component_id="column_layout-1750075614" data-component_title="Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment | School of Optometry & Vision Science - UNSW Sydney"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12"> <div class="responsivegrid aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--12 aem-GridColumn--medium--12 aem-GridColumn--small--12 aem-GridColumn--offset--default--0"> <div class="degree-page-header uds-component section"> <div class="page-header background-shape-2" data-component_type="page-header" data-component_id="page_header-1685760428" data-component_title="Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment"> <div class="content"> <h1>Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment</h1> <p></p> </div> <div class="media"> <div class="media-inner"> <picture> <source media="(min-width:768px)" srcset="/content/dam/images/medicine-health/optometry-vision-science/news/2022-10-john-goris/2-2023-dendritic-cells.cropimg.width=700.crop=video.jpg 700w,/content/dam/images/medicine-health/optometry-vision-science/news/2022-10-john-goris/2-2023-dendritic-cells.cropimg.width=335.crop=video.jpg 335w"/> <img src="/content/dam/images/medicine-health/optometry-vision-science/news/2022-10-john-goris/2-2023-dendritic-cells.cropimg.width=335.crop=video.jpg" alt="Dendritic cells protecting the host from viral infection" loading="lazy" data-aem-asset-id="4f91d86c-214c-419a-9737-b9fc9d890995" data-trackable="true" title="Dendritic cells"/> </picture> </div> </div> </div> </div> </div> </div> </span></div> <div class="column-layout uds-component padded-left padded-right padded-left__small--0 padded-right__small--0 aem-GridColumn aem-GridColumn--default--12"> <span data-component_type="column-layout" data-component_id="column_layout-1728537641" data-component_title="Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment | School of Optometry & Vision Science - UNSW Sydney"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12"> <div class="responsivegrid aem-GridColumn--default--none aem-GridColumn aem-GridColumn--default--12 aem-GridColumn--medium--12 aem-GridColumn--small--12 aem-GridColumn--offset--default--0"> <div class="text uds-component section"> <span data-component_type="text" data-component_id="text-1194881087" data-component_title="Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment | School of Optometry & Vision Science - UNSW Sydney"> <div class="cmp-text"> <p>Dendritic cells (DC) are a subtype of immune cells, which play a pivotal role in the maintenance of ocular surface health and homeostasis and reside in the human cornea and conjunctiva. Using in vivo confocal microscopy, it is possible to examine DC in real time.</p> <p>Observation of DC can be used to investigate changes occurring during ocular surface disease and to monitor the efficacy of treatment. Evaluation of alterations in DC density and morphology in the context of ocular surface disease or treatment requires the use of repeated observations. Characterisation of variations in DC density and morphology over the course of a day, and day-to-day repeatability of measurements is thus essential to enable normal variations to be differentiated from changes that can be attributed to disease processes.</p> <p>Our research showed no diurnal variation in DC density, morphology, or topographical distribution using in vivo confocal microscopy at the ocular surface in healthy individuals. Read more about this here:</p> <p><a href="https://onlinelibrary.wiley.com/doi/10.1111/opo.13087">https://onlinelibrary.wiley.com/doi/10.1111/opo.13087</a></p> </div> </span> </div> </div> </div> </span></div> </div> </div> <div class="responsivegrid aem-GridColumn--offset--medium--0 aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--default--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--default--8 aem-GridColumn--offset--default--0"> <div class="aem-Grid aem-Grid--8 aem-Grid--small--12 aem-Grid--default--8 aem-Grid--medium--12 "> </div> </div> <div class="responsivegrid aem-GridColumn--offset--medium--0 aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--default--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--12 aem-GridColumn--offset--small--0 aem-GridColumn--offset--default--0 aem-GridColumn--default--4"> <div class="aem-Grid aem-Grid--4 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Diurnal changes and topographical distribution of ocular surface epithelial dendritic cells in humans, and repeatability of density and morphology assessment | School of Optometry & Vision Science - UNSW Sydney