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University</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span><a class="ri-more-link js-profile-ri-list-card" data-click-track="profile-user-info-primary-research-interest" data-has-card-for-ri-list="47968559">View All (7)</a></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="47968559" href="https://www.academia.edu/Documents/in/Mitochondrial_Respiratory_Chain"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://marshfieldclinic.academia.edu/JaimeBoero","location":"/JaimeBoero","scheme":"https","host":"marshfieldclinic.academia.edu","port":null,"pathname":"/JaimeBoero","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" 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data-props="{"color":"gray","children":["Enzyme"]}" data-trace="false" data-dom-id="Pill-react-component-73ed6b09-6b37-4a60-9c3b-7d1bd2b443a9"></div> <div id="Pill-react-component-73ed6b09-6b37-4a60-9c3b-7d1bd2b443a9"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Jaime Boero</h3></div><div class="js-work-strip profile--work_container" data-work-id="111352560"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111352560/Increased_brain_capillaries_in_chronic_hypoxia"><img alt="Research paper thumbnail of Increased brain capillaries in chronic hypoxia" class="work-thumbnail" src="https://attachments.academia-assets.com/108917179/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111352560/Increased_brain_capillaries_in_chronic_hypoxia">Increased brain capillaries in chronic hypoxia</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span><span>, Apr 1, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain vessels ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain vessels was studied in Balb/c mice. In comparison to age-matched controls kept at sea level, emulsion-perfused capillaries in hypoxic mice showed marked dilation in all brain areas studied. Capillary length per unit volume of tissue (L v) was increased in the cerebellar granular layer, the caudate nucleus, the globus pallidus, the substantia nigra, the superior colliculus, and the dentate gyrus. There was a selective increase of L v in the hippocampus (CA1 strata pyramidale and lacunosum and CA3 strata pyramidale and oriens) and in somatosensory cortex layers V and VI, motor cortex layers II, III, V, and VI, and auditory cortex layers II and III. An increase in capillary surface area per unit volume of tissue was also determined in several brain areas, including layer IV of somatosensory cortex, where L v was not significantly increased. The O 2 diffusion conductance and PO 2 in the tissues were estimated with a mathematical model. The remodeling of capillary diameter and length during chronic hypoxia accounts for the significant increase of O 2 conductance to neural tissues. Also the estimated tissue PO 2 in chronic brain hypoxia is markedly increased in the caudate nucleus and the substantia nigra compared with acute hypoxia. These results suggest that formation of new capillaries is an important mechanism to restore the O 2 deficit in chronic brain hypoxia and that local rates of energy utilization may influence angiogenesis in different areas of the brain. whisker barrels; capillary remodeling</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3805f7933309b03ff99e12bbc9753efc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917179,"asset_id":111352560,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917179/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352560"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352560"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352560; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111352558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111352558/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives"><img alt="Research paper thumbnail of Molecular characterization of the creatine kinases and some historical perspectives" class="work-thumbnail" src="https://attachments.academia-assets.com/108917192/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111352558/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives">Molecular characterization of the creatine kinases and some historical perspectives</a></div><div class="wp-workCard_item"><span>Springer eBooks</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has pa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has paralleled the molecular revolution of understanding gene structure, function, and regulation. In this review, we present a summary of advances in molecular analysis of the CK gene family with a few vignettes of historical interest. We describe how the muscle CK gene provided an essential model system to examine myogenic regulatory mechanisms, leading to the discovery of the binding site for the MyoD family of basic helix-loop-helix transcription factors essential in skeletal myogenesis and the characterization of the MEF2 family of factors with an A/T rich consensus binding site essential in skeletal myogenesis and cardiogenesis. Cloning and characterization of the four mRNAs and nuclear genes encoding the cytosolic CKs, muscle and brain CKs, and the mitochondrial (Mt) CKs, sarcomeric MtCK and ubiquitous MtCK, has allowed intriguing study of tissue-specific and cell-specific expression of the different CKs and analysis of structural, functional, regulatory, and evolutionary relationships among both the four CK proteins and genes. Current and future studies focus on understanding both cellular energetics facilitated by the CK enzymes, especially energy channelling from the site of production, the mitochondrial matrix and inner membrane, to various cytosolic foci of utilization, and regulation of MtCK gene expression at the cell and tissue-specific level as models of regulation of energy producing genes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b5273abee4e9bb936028fef3c7c9a8b9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917192,"asset_id":111352558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917192/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352558; 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</script> <div class="js-work-strip profile--work_container" data-work-id="111352552"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111352552/Mitochondrial_%CE%B2_Oxidation_Enzymes_Are_Regionally_Expressed_in_the_Mouse_Brain_1856"><img alt="Research paper thumbnail of Mitochondrial β-Oxidation Enzymes Are Regionally Expressed in the Mouse Brain † 1856" class="work-thumbnail" src="https://attachments.academia-assets.com/108917135/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111352552/Mitochondrial_%CE%B2_Oxidation_Enzymes_Are_Regionally_Expressed_in_the_Mouse_Brain_1856">Mitochondrial β-Oxidation Enzymes Are Regionally Expressed in the Mouse Brain † 1856</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, Apr 1, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8cb514a81c45ec6e7da360badc98fa0c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917135,"asset_id":111352552,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917135/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352552"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352552"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352552; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111352533"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111352533/Octamer_Formation_and_Coupling_of_Cardiac_Sarcomeric_Mitochondrial_Creatine_Kinase_Are_Mediated_by_Charged_N_terminal_Residues"><img alt="Research paper thumbnail of Octamer Formation and Coupling of Cardiac Sarcomeric Mitochondrial Creatine Kinase Are Mediated by Charged N-terminal Residues" class="work-thumbnail" src="https://attachments.academia-assets.com/108917184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111352533/Octamer_Formation_and_Coupling_of_Cardiac_Sarcomeric_Mitochondrial_Creatine_Kinase_Are_Mediated_by_Charged_N_terminal_Residues">Octamer Formation and Coupling of Cardiac Sarcomeric Mitochondrial Creatine Kinase Are Mediated by Charged N-terminal Residues</a></div><div class="wp-workCard_item"><span>Journal of Biological Chemistry</span><span>, Sep 1, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mitochondrial creatine kinases form octameric structures composed of four active and stable dimer...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mitochondrial creatine kinases form octameric structures composed of four active and stable dimers. Octamer formation has been postulated to occur via interaction of the charged amino acids in the N-terminal peptide of the mature enzyme. We altered codons for charged amino acids in the N-terminal region of mature sarcomeric mitochondrial creatine kinase (sMtCK) to those encoding neutral amino acids. Transfection of normal sMtCK cDNA or those with the mutations R42G, E43G/H45G, and K46G into rat neonatal cardiomyocytes resulted in enzymatically active sMtCK expression in all. After hypoosmotic treatment of isolated mitochondria, mitochondrial inner membrane-associated and soluble sMtCK from the intermembranous space were measured. The R42G and E43G/H45G double mutation caused destabilization of the octameric structure of sMtCK and a profound reduction in binding of sMtCK to the inner mitochondrial membrane. The other mutant sMtCK proteins had modest reductions in binding. Creatine-stimulated respiration was markedly reduced in mitochondria isolated from cells transfected with the R42G mutant cDNA as compared with those transfected with normal sMtCK cDNA. We conclude that neutralization of charges in N-terminal peptide resulted in destabilization of octamer structure of sMtCK. Thus, charged amino acids at the N-terminal moiety of mature sMtCK are essential for octamer formation, binding of sMtCK with inner mitochondrial membrane, and coupling of sMtCK to oxidative phosphorylation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e40e7d3da878b7c1bc826fd197d6f5be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917184,"asset_id":111352533,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917184/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352533"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352533"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352533; 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</script> <div class="js-work-strip profile--work_container" data-work-id="90795669"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795669/Mild_Neurological_Signs_in_FMR1_Premutation_Women_in_an_Unselected_Community_Based_Cohort"><img alt="Research paper thumbnail of Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community‐Based Cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/94260086/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795669/Mild_Neurological_Signs_in_FMR1_Premutation_Women_in_an_Unselected_Community_Based_Cohort">Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community‐Based Cohort</a></div><div class="wp-workCard_item"><span>Movement Disorders</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Premutation sized (55-200) CGG repeat expansions in the FMR1 gene cause Fragile X-ass...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Premutation sized (55-200) CGG repeat expansions in the FMR1 gene cause Fragile X-associated Tremor Ataxia Syndrome (FXTAS). Most studies of premutation carriers utilized reverse ascertainment to identify cases, leading to a selection bias for larger repeats. As shorter CGG premutation repeats are common in the population, understanding their impact on health outcomes has a potentially large public health footprint. Objectives: The study's objective was to compare an unselected group of premutation carriers (n=35, 55-101 CGG repeats) with matched controls (n=61, 29-39 CGG repeats) with respect to FXTAS-type signs using structured neurological assessments. Methods: Three neurologists independently rated signs, using an adapted version of the FXTAS Rating Scale (1). This was a double-blind study, as genetic status (premutation versus control) was known neither by the participants nor any of the neurologists. Analyses controlled potentially confounding comborbid conditions in the electronic health record (e.g., osteoarthritis, stroke) and probed the association of age with signs. Results: Although there was no overall difference between carriers and controls, among individuals without any potentially confounding comorbid diagnoses, there was a statistically significant age-associated elevation in FXTAS-type signs in premutation carriers compared to controls.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="50fe2d527fcab47a873c97102fb4037b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260086,"asset_id":90795669,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260086/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795669"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795669"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795669; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90795669]").text(description); $(".js-view-count[data-work-id=90795669]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90795669; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90795669']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "50fe2d527fcab47a873c97102fb4037b" } } $('.js-work-strip[data-work-id=90795669]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90795669,"title":"Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community‐Based Cohort","internal_url":"https://www.academia.edu/90795669/Mild_Neurological_Signs_in_FMR1_Premutation_Women_in_an_Unselected_Community_Based_Cohort","owner_id":47968559,"coauthors_can_edit":true,"owner":{"id":47968559,"first_name":"Jaime","middle_initials":null,"last_name":"Boero","page_name":"JaimeBoero","domain_name":"marshfieldclinic","created_at":"2016-04-29T09:29:32.998-07:00","display_name":"Jaime Boero","url":"https://marshfieldclinic.academia.edu/JaimeBoero"},"attachments":[{"id":94260086,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94260086/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94260086/download_file","bulk_download_file_name":"Mild_Neurological_Signs_in_FMR1_Premutat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94260086/pdf-libre.pdf?1668486921=\u0026response-content-disposition=attachment%3B+filename%3DMild_Neurological_Signs_in_FMR1_Premutat.pdf\u0026Expires=1739808232\u0026Signature=UWnlxEi-~IXtOQTV8i6YLsO8SlQWrwEZNFJaeKTi4GyaQJMR7o3aY7oT2o12K7TOQOTsx143kNhxARg3XshxgU~w~PVa2tjsgiaK8pwD0AcTSecdoqvU355aovzdio5LLndkZfPWT9TrkGJN0Wf0xkAnkj1iqr235yV72nydtpSYNc~75vTtTGpU1L~NhtLB3SL8tkYV9CFIRM3O1gioMpORgMZjZyRMKMcMVpSqrmXPhrWcWHze9lfWkz6K6cTXEau9tKzdqaoQu0dzS5c1rxY2wQj83wiWrTkc9p-q9t5ij~d6Q2RU8UDWdUzXpdEBmIfRbLJ26FKk8DPtyUPSBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795668"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90795668/Methods_for_detecting_sleepiness"><img alt="Research paper thumbnail of Methods for detecting sleepiness" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90795668/Methods_for_detecting_sleepiness">Methods for detecting sleepiness</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795668"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795668"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795668; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90795668]").text(description); $(".js-view-count[data-work-id=90795668]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90795668; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90795668']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90795668]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90795668,"title":"Methods for detecting sleepiness","internal_url":"https://www.academia.edu/90795668/Methods_for_detecting_sleepiness","owner_id":47968559,"coauthors_can_edit":true,"owner":{"id":47968559,"first_name":"Jaime","middle_initials":null,"last_name":"Boero","page_name":"JaimeBoero","domain_name":"marshfieldclinic","created_at":"2016-04-29T09:29:32.998-07:00","display_name":"Jaime Boero","url":"https://marshfieldclinic.academia.edu/JaimeBoero"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795667"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia"><img alt="Research paper thumbnail of Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia" class="work-thumbnail" src="https://attachments.academia-assets.com/94260089/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia">Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia</a></div><div class="wp-workCard_item"><span>Neuroscience Letters</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Respiratory activity and NADH CoQ reductase (complex I) and cytochrome c oxidase (complex IV) act...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Respiratory activity and NADH CoQ reductase (complex I) and cytochrome c oxidase (complex IV) activities were measured in free (non-synaptosomal) mitochondria isolated from cerebral cortex of male Balb/c mice exposed to intermittent hypobaric hypoxia (450 Torr; 4300 m) for 21 days and compared to normoxic (sea level) controls. In the hypoxic we found a 47% reduction of oxygen uptake during state 3 (ADP and substrate present), 12% reduction during state 4 (no ADP present) and 20% reduction in the uncoupled respiration rate with pymvate plus malate as substrates. Respiratory control ratio (RCR) decreased by 24%. No change in the ADP/O ratio was seen. NADH CoQ reductase activity decreased by 30% and cytochrome c oxidase by 17%, suggesting that under conditions of chronic hypoxia, the reductions of mitochondrial respiratory activities are caused, at least in part, by enzymatic alterations of the electron transport chain (complex I and complex IV). The decreased activity of these enzymes could contribute to alterations in neuronal activity by reducing brain energy metabolism during development under conditions of chronic hypoxia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="288c521b48020d3767ff22096a108069" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260089,"asset_id":90795667,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260089/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795667"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795667"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795667; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90795667]").text(description); $(".js-view-count[data-work-id=90795667]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90795667; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90795667']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "288c521b48020d3767ff22096a108069" } } $('.js-work-strip[data-work-id=90795667]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90795667,"title":"Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia","internal_url":"https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia","owner_id":47968559,"coauthors_can_edit":true,"owner":{"id":47968559,"first_name":"Jaime","middle_initials":null,"last_name":"Boero","page_name":"JaimeBoero","domain_name":"marshfieldclinic","created_at":"2016-04-29T09:29:32.998-07:00","display_name":"Jaime Boero","url":"https://marshfieldclinic.academia.edu/JaimeBoero"},"attachments":[{"id":94260089,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94260089/thumbnails/1.jpg","file_name":"0304-3940_2895_2911692-p20221115-1-tawpfj.pdf","download_url":"https://www.academia.edu/attachments/94260089/download_file","bulk_download_file_name":"Reduced_mitochondrial_respiration_in_mou.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94260089/0304-3940_2895_2911692-p20221115-1-tawpfj-libre.pdf?1668486924=\u0026response-content-disposition=attachment%3B+filename%3DReduced_mitochondrial_respiration_in_mou.pdf\u0026Expires=1739808232\u0026Signature=I2GpZatqy6Y2I5E0xuAS-drK42emAtpg94LWt~6msgg7w4ZhdaxeRvh7FyZpgQ58D~tamyVQKbQDaHgge2pMUh1moAnP~SiBuR1tXPr0csa3kwZfg7S5yyZ5xdr9FrVBS78dxRIOm~rav-XAbj7oir-kcAily6yLCTi6pQPMLVpf1hm1LbkUXPAupnRmHsoOVrDfl5xItRzPS5I79Erzz2thCsATeQHKtayWwZkLP0AHJsRTIsGCaWD-t32V5sePvWUprqzN~szf4lpscuYdyxV5YiF5W-heA9IUpiNM66z7nDZtaYuwg5Aquut9A18nqmgTP1EugkTDtuywkNv2GQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795666"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795666/Deletion_of_the_n_terminus_of_murine_map2_by_gene_targeting_disrupts_hippocampal_ca1_neuron_architecture_and_alters_contextual_memory"><img alt="Research paper thumbnail of Deletion of the n-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory" class="work-thumbnail" src="https://attachments.academia-assets.com/94260094/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795666/Deletion_of_the_n_terminus_of_murine_map2_by_gene_targeting_disrupts_hippocampal_ca1_neuron_architecture_and_alters_contextual_memory">Deletion of the n-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory</a></div><div class="wp-workCard_item"><span>Neuroscience</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Microtubule-associated protein-2 (MAP2) is a brain specific A-kinase anchoring protein that targe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Microtubule-associated protein-2 (MAP2) is a brain specific A-kinase anchoring protein that targets the cyclic AMP-dependent protein kinase holoenzyme (PKA) to microtubules. Phosphorylation of MAP2 by different protein kinases is crucial for neuronal growth. The N-terminus of MAP2 contains the binding site for regulatory subunit II of cAMPdependent protein kinase (PKA-RII␤). Using homologous recombination, we created a mutant line of mice (⌬1-158) that express truncated MAP2 lacking the N-terminal peptide and the PKA binding site. Deletion of the PKA binding site from the MAP2 gene resulted in decreased efficiency of MAP2 phosphorylation. Biochemical and immunohistochemical studies demonstrate major changes in the morphology of hippocampal neurons in ⌬1-158 mice. Behavioral tests indicate that ⌬1-158 mice were impaired (exhibited less conditioned freezing) relative to Wild-Type (WT) controls during a test of contextual, but not during auditory cue, fear conditioning when tested at 8 weeks or 8 months of age. The ⌬1-158 mice displayed a heightened sensitivity to shock at 8 weeks, but not at 8 months of age. We conclude that PKA binding to MAP2 and MAP2 phosphorylation is essential for the selective development of contextual memory.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ab4154566f518d964814c83f032827ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260094,"asset_id":90795666,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260094/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795666"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795666"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795666; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795576"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795576/Energetic_metabolism_in_mouse_cerebral_cortex_during_chronic_hypoxia"><img alt="Research paper thumbnail of Energetic metabolism in mouse cerebral cortex during chronic hypoxia" class="work-thumbnail" src="https://attachments.academia-assets.com/94260051/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795576/Energetic_metabolism_in_mouse_cerebral_cortex_during_chronic_hypoxia">Energetic metabolism in mouse cerebral cortex during chronic hypoxia</a></div><div class="wp-workCard_item"><span>Neuroscience Letters</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We measured the activities of Na 1 K 1 ATPase and of enzymes of the glycolytic pathway, Krebs cyc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We measured the activities of Na 1 K 1 ATPase and of enzymes of the glycolytic pathway, Krebs cycle, and the respiratory chain in cerebral cortex of mice exposed to chronic hypoxia for three weeks and compared their values with those of sea level controls. There were no differences in Na 1 K 1 ATPase activity or in the activity of glycolytic enzymes. In the Krebs cycle, a 66% increase of succinate dehydrogenase activity was found due to a lower Km. In contrast, respiratory chain cytochrome oxidase activity was reduced by 12% in mice exposed to hypoxia. This suggested that the metabolic demand would be satis®ed despite the respiratory chain depression (cytochrome oxidase), probably due to anaerobic energy production within the mitochondria (succinate dehydrogenase).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="14cac15ee8b8bd4f33f9d15c03128ad3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260051,"asset_id":90795576,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260051/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795576"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795576"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795576; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74170497"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74170497/Increased_brain_capillaries_in_chronic_hypoxia"><img alt="Research paper thumbnail of Increased brain capillaries in chronic hypoxia" class="work-thumbnail" src="https://attachments.academia-assets.com/82623725/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74170497/Increased_brain_capillaries_in_chronic_hypoxia">Increased brain capillaries in chronic hypoxia</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain vessels ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain vessels was studied in Balb/c mice. In comparison to age-matched controls kept at sea level, emulsion-perfused capillaries in hypoxic mice showed marked dilation in all brain areas studied. Capillary length per unit volume of tissue ( L v) was increased in the cerebellar granular layer, the caudate nucleus, the globus pallidus, the substantia nigra, the superior colliculus, and the dentate gyrus. There was a selective increase of L v in the hippocampus (CA1 strata pyramidale and lacunosum and CA3 strata pyramidale and oriens) and in somatosensory cortex layers V and VI, motor cortex layers II, III, V, and VI, and auditory cortex layers II and III. An increase in capillary surface area per unit volume of tissue was also determined in several brain areas, including layer IV of somatosensory cortex, where L v was not significantly increased. The O2diffusion conductance and [Formula: see text] in th...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dd45cff3dfd753f942d7a74eaf508578" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82623725,"asset_id":74170497,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82623725/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74170497"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74170497"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74170497; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66824390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66824390/Identification_of_a_biomarker_for_sleep_drive_in_flies_and_humans"><img alt="Research paper thumbnail of Identification of a biomarker for sleep drive in flies and humans" class="work-thumbnail" src="https://attachments.academia-assets.com/77869080/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66824390/Identification_of_a_biomarker_for_sleep_drive_in_flies_and_humans">Identification of a biomarker for sleep drive in flies and humans</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences of the United States of America</span><span>, Jan 26, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is a common experience to sacrifice sleep to meet the demands of our 24-h society. Current est...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is a common experience to sacrifice sleep to meet the demands of our 24-h society. Current estimates reveal that as a society, we sleep on average 2 h less than we did 40 years ago. This level of sleep restriction results in negative health outcomes and is sufficient to produce cognitive deficits and reduced attention and is associated with increased risk for traffic and occupational accidents. Unfortunately, there is no simple quantifiable marker that can detect an individual who is excessively sleepy before adverse outcomes become evident. To address this issue, we have developed a simple and effective strategy for identifying biomarkers of sleepiness by using genetic and pharmacological tools that dissociate sleep drive from wake time in the model organism Drosophila melanogaster. These studies have identified a biomarker, Amylase, that is highly correlated with sleep drive. More importantly, both salivary Amylase activity and mRNA levels are also responsive to extended waking...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="940e7dc12840221953d083bac13663b4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77869080,"asset_id":66824390,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77869080/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66824390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66824390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66824390; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24882969"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24882969/Restricted_neuronal_expression_of_ubiquitous_mitochondrial_creatine_kinase_changing_patterns_in_development_and_with_increased_activity"><img alt="Research paper thumbnail of Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: changing patterns in development and with increased activity" class="work-thumbnail" src="https://attachments.academia-assets.com/45203944/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24882969/Restricted_neuronal_expression_of_ubiquitous_mitochondrial_creatine_kinase_changing_patterns_in_development_and_with_increased_activity">Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: changing patterns in development and with increased activity</a></div><div class="wp-workCard_item"><span>Molecular and cellular biochemistry</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Whereas ATP consumption increases with neural activity and is buffered by phosphocreatine (PCr), ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Whereas ATP consumption increases with neural activity and is buffered by phosphocreatine (PCr), it is not known whether PCr synthesis by ubiquitous mitochondrial creatine kinase (uMtCK) supports energy metabolism in all neurons. To explore the possibility that uMtCK expression in neurons is modulated by activity and during development, we used immunocytochemistry to detect uMtCK-containing mitochondria. In the adult brain, subsets of neurons including layer Va pyramidal cells, most thalamic nuclei, cerebellar Purkinje cells, olfactory mitral cells and hippocampal interneurons strongly express uMtCK. uMtCK is transiently expressed by a larger group of neurons at birth. Neurons in all cortical layers express uMtCK at birth (P0), but uMtCK is restricted to layer Va by P12. uMtCK is detected in cerebellar Purkinje cells at birth, but localization to dendrites is only observed after P5 and is maximal on P14. Hippocampal CA1 and CA3 pyramidal neurons contain uMtCK-positive mitochondria a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="94ba48d6e5b0b84ee1f4bb168804a88f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45203944,"asset_id":24882969,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45203944/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24882969"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24882969"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24882969; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24882968"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24882968/Oxidative_myocytes_of_heart_and_skeletal_muscle_express_abundant_sarcomeric_mitochondrial_creatine_kinase"><img alt="Research paper thumbnail of Oxidative myocytes of heart and skeletal muscle express abundant sarcomeric mitochondrial creatine kinase" class="work-thumbnail" src="https://attachments.academia-assets.com/45203928/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24882968/Oxidative_myocytes_of_heart_and_skeletal_muscle_express_abundant_sarcomeric_mitochondrial_creatine_kinase">Oxidative myocytes of heart and skeletal muscle express abundant sarcomeric mitochondrial creatine kinase</a></div><div class="wp-workCard_item"><span>The Histochemical journal</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sarcomeric mitochondrial creatine kinase catalyzes the reversible transfer of a high energy phosp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sarcomeric mitochondrial creatine kinase catalyzes the reversible transfer of a high energy phosphate between ATP and creatine. To study cellular distribution of the kinase, we performed immunocytochemical studies using a peptide antiserum specific for the kinase protein. Our results demonstrated that the sarcomeric mitochondrial creatine kinase gene is abundantly expressed in heart and skeletal muscle, with no protein detected in other tissues examined, including brain, lung, liver, spleen, kidney, bladder, testis, stomach, intestine, and colon. RNA blot study showed that there is no detectable expression of the kinase mRNA in the thymus gland. In heart and skeletal muscle, the kinase protein is expressed in atrial and ventricular cardiomyocytes and a subpopulation of skeletal myofibres. In skeletal muscle, fast myosin heavy chain co-localization studies demonstrated that the sarcomeric mitochondrial creatine kinase is highly expressed in type 1, slow-oxidative and type 2A, fast-ox...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d4db7c8fd59318472447a72ee29a45e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45203928,"asset_id":24882968,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45203928/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24882968"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24882968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24882968; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24882967"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24882967/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives"><img alt="Research paper thumbnail of Molecular characterization of the creatine kinases and some historical perspectives" class="work-thumbnail" src="https://attachments.academia-assets.com/45203929/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24882967/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives">Molecular characterization of the creatine kinases and some historical perspectives</a></div><div class="wp-workCard_item"><span>Bioenergetics of the Cell: Quantitative Aspects</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has pa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has paralleled the molecular revolution of understanding gene structure, function, and regulation. In this review, we present a summary of advances in molecular analysis of the CK gene family with a few vignettes of historical interest. We describe how the muscle CK gene provided an essential model system to examine myogenic regulatory mechanisms, leading to the discovery of the binding site for the MyoD family of basic helix-loop-helix transcription factors essential in skeletal myogenesis and the characterization of the MEF2 family of factors with an A/T rich consensus binding site essential in skeletal myogenesis and cardiogenesis. Cloning and characterization of the four mRNAs and nuclear genes encoding the cytosolic CKs, muscle and brain CKs, and the mitochondrial (Mt) CKs, sarcomeric MtCK and ubiquitous MtCK, has allowed intriguing study of tissue-specific and cell-specific expression of the different CKs and analysis of structural, functional, regulatory, and evolutionary relationships among both the four CK proteins and genes. Current and future studies focus on understanding both cellular energetics facilitated by the CK enzymes, especially energy channelling from the site of production, the mitochondrial matrix and inner membrane, to various cytosolic foci of utilization, and regulation of MtCK gene expression at the cell and tissue-specific level as models of regulation of energy producing genes. (Mol Cell Biochem 184: [153][154][155][156][157][158][159][160][161][162][163][164][165][166][167] 1998)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6e3e516f432b4c2fc6e9f18365034f44" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45203929,"asset_id":24882967,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45203929/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24882967"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24882967"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24882967; 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In comparison to age-matched controls kept at sea level, emulsion-perfused capillaries in hypoxic mice showed marked dilation in all brain areas studied. Capillary length per unit volume of tissue (L v) was increased in the cerebellar granular layer, the caudate nucleus, the globus pallidus, the substantia nigra, the superior colliculus, and the dentate gyrus. There was a selective increase of L v in the hippocampus (CA1 strata pyramidale and lacunosum and CA3 strata pyramidale and oriens) and in somatosensory cortex layers V and VI, motor cortex layers II, III, V, and VI, and auditory cortex layers II and III. An increase in capillary surface area per unit volume of tissue was also determined in several brain areas, including layer IV of somatosensory cortex, where L v was not significantly increased. The O 2 diffusion conductance and PO 2 in the tissues were estimated with a mathematical model. The remodeling of capillary diameter and length during chronic hypoxia accounts for the significant increase of O 2 conductance to neural tissues. Also the estimated tissue PO 2 in chronic brain hypoxia is markedly increased in the caudate nucleus and the substantia nigra compared with acute hypoxia. These results suggest that formation of new capillaries is an important mechanism to restore the O 2 deficit in chronic brain hypoxia and that local rates of energy utilization may influence angiogenesis in different areas of the brain. whisker barrels; capillary remodeling</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3805f7933309b03ff99e12bbc9753efc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917179,"asset_id":111352560,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917179/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352560"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352560"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352560; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111352558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111352558/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives"><img alt="Research paper thumbnail of Molecular characterization of the creatine kinases and some historical perspectives" class="work-thumbnail" src="https://attachments.academia-assets.com/108917192/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111352558/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives">Molecular characterization of the creatine kinases and some historical perspectives</a></div><div class="wp-workCard_item"><span>Springer eBooks</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has pa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has paralleled the molecular revolution of understanding gene structure, function, and regulation. In this review, we present a summary of advances in molecular analysis of the CK gene family with a few vignettes of historical interest. We describe how the muscle CK gene provided an essential model system to examine myogenic regulatory mechanisms, leading to the discovery of the binding site for the MyoD family of basic helix-loop-helix transcription factors essential in skeletal myogenesis and the characterization of the MEF2 family of factors with an A/T rich consensus binding site essential in skeletal myogenesis and cardiogenesis. Cloning and characterization of the four mRNAs and nuclear genes encoding the cytosolic CKs, muscle and brain CKs, and the mitochondrial (Mt) CKs, sarcomeric MtCK and ubiquitous MtCK, has allowed intriguing study of tissue-specific and cell-specific expression of the different CKs and analysis of structural, functional, regulatory, and evolutionary relationships among both the four CK proteins and genes. Current and future studies focus on understanding both cellular energetics facilitated by the CK enzymes, especially energy channelling from the site of production, the mitochondrial matrix and inner membrane, to various cytosolic foci of utilization, and regulation of MtCK gene expression at the cell and tissue-specific level as models of regulation of energy producing genes.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b5273abee4e9bb936028fef3c7c9a8b9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917192,"asset_id":111352558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917192/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352558; 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</script> <div class="js-work-strip profile--work_container" data-work-id="111352552"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111352552/Mitochondrial_%CE%B2_Oxidation_Enzymes_Are_Regionally_Expressed_in_the_Mouse_Brain_1856"><img alt="Research paper thumbnail of Mitochondrial β-Oxidation Enzymes Are Regionally Expressed in the Mouse Brain † 1856" class="work-thumbnail" src="https://attachments.academia-assets.com/108917135/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111352552/Mitochondrial_%CE%B2_Oxidation_Enzymes_Are_Regionally_Expressed_in_the_Mouse_Brain_1856">Mitochondrial β-Oxidation Enzymes Are Regionally Expressed in the Mouse Brain † 1856</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, Apr 1, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8cb514a81c45ec6e7da360badc98fa0c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917135,"asset_id":111352552,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917135/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352552"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352552"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352552; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111352533"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111352533/Octamer_Formation_and_Coupling_of_Cardiac_Sarcomeric_Mitochondrial_Creatine_Kinase_Are_Mediated_by_Charged_N_terminal_Residues"><img alt="Research paper thumbnail of Octamer Formation and Coupling of Cardiac Sarcomeric Mitochondrial Creatine Kinase Are Mediated by Charged N-terminal Residues" class="work-thumbnail" src="https://attachments.academia-assets.com/108917184/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111352533/Octamer_Formation_and_Coupling_of_Cardiac_Sarcomeric_Mitochondrial_Creatine_Kinase_Are_Mediated_by_Charged_N_terminal_Residues">Octamer Formation and Coupling of Cardiac Sarcomeric Mitochondrial Creatine Kinase Are Mediated by Charged N-terminal Residues</a></div><div class="wp-workCard_item"><span>Journal of Biological Chemistry</span><span>, Sep 1, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mitochondrial creatine kinases form octameric structures composed of four active and stable dimer...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mitochondrial creatine kinases form octameric structures composed of four active and stable dimers. Octamer formation has been postulated to occur via interaction of the charged amino acids in the N-terminal peptide of the mature enzyme. We altered codons for charged amino acids in the N-terminal region of mature sarcomeric mitochondrial creatine kinase (sMtCK) to those encoding neutral amino acids. Transfection of normal sMtCK cDNA or those with the mutations R42G, E43G/H45G, and K46G into rat neonatal cardiomyocytes resulted in enzymatically active sMtCK expression in all. After hypoosmotic treatment of isolated mitochondria, mitochondrial inner membrane-associated and soluble sMtCK from the intermembranous space were measured. The R42G and E43G/H45G double mutation caused destabilization of the octameric structure of sMtCK and a profound reduction in binding of sMtCK to the inner mitochondrial membrane. The other mutant sMtCK proteins had modest reductions in binding. Creatine-stimulated respiration was markedly reduced in mitochondria isolated from cells transfected with the R42G mutant cDNA as compared with those transfected with normal sMtCK cDNA. We conclude that neutralization of charges in N-terminal peptide resulted in destabilization of octamer structure of sMtCK. Thus, charged amino acids at the N-terminal moiety of mature sMtCK are essential for octamer formation, binding of sMtCK with inner mitochondrial membrane, and coupling of sMtCK to oxidative phosphorylation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e40e7d3da878b7c1bc826fd197d6f5be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108917184,"asset_id":111352533,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108917184/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111352533"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111352533"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111352533; 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</script> <div class="js-work-strip profile--work_container" data-work-id="90795669"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795669/Mild_Neurological_Signs_in_FMR1_Premutation_Women_in_an_Unselected_Community_Based_Cohort"><img alt="Research paper thumbnail of Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community‐Based Cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/94260086/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795669/Mild_Neurological_Signs_in_FMR1_Premutation_Women_in_an_Unselected_Community_Based_Cohort">Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community‐Based Cohort</a></div><div class="wp-workCard_item"><span>Movement Disorders</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Premutation sized (55-200) CGG repeat expansions in the FMR1 gene cause Fragile X-ass...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Premutation sized (55-200) CGG repeat expansions in the FMR1 gene cause Fragile X-associated Tremor Ataxia Syndrome (FXTAS). Most studies of premutation carriers utilized reverse ascertainment to identify cases, leading to a selection bias for larger repeats. As shorter CGG premutation repeats are common in the population, understanding their impact on health outcomes has a potentially large public health footprint. Objectives: The study's objective was to compare an unselected group of premutation carriers (n=35, 55-101 CGG repeats) with matched controls (n=61, 29-39 CGG repeats) with respect to FXTAS-type signs using structured neurological assessments. Methods: Three neurologists independently rated signs, using an adapted version of the FXTAS Rating Scale (1). This was a double-blind study, as genetic status (premutation versus control) was known neither by the participants nor any of the neurologists. Analyses controlled potentially confounding comborbid conditions in the electronic health record (e.g., osteoarthritis, stroke) and probed the association of age with signs. Results: Although there was no overall difference between carriers and controls, among individuals without any potentially confounding comorbid diagnoses, there was a statistically significant age-associated elevation in FXTAS-type signs in premutation carriers compared to controls.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="50fe2d527fcab47a873c97102fb4037b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260086,"asset_id":90795669,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260086/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795669"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795669"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795669; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90795669]").text(description); $(".js-view-count[data-work-id=90795669]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90795669; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90795669']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "50fe2d527fcab47a873c97102fb4037b" } } $('.js-work-strip[data-work-id=90795669]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90795669,"title":"Mild Neurological Signs in FMR1 Premutation Women in an Unselected Community‐Based Cohort","internal_url":"https://www.academia.edu/90795669/Mild_Neurological_Signs_in_FMR1_Premutation_Women_in_an_Unselected_Community_Based_Cohort","owner_id":47968559,"coauthors_can_edit":true,"owner":{"id":47968559,"first_name":"Jaime","middle_initials":null,"last_name":"Boero","page_name":"JaimeBoero","domain_name":"marshfieldclinic","created_at":"2016-04-29T09:29:32.998-07:00","display_name":"Jaime Boero","url":"https://marshfieldclinic.academia.edu/JaimeBoero"},"attachments":[{"id":94260086,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94260086/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/94260086/download_file","bulk_download_file_name":"Mild_Neurological_Signs_in_FMR1_Premutat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94260086/pdf-libre.pdf?1668486921=\u0026response-content-disposition=attachment%3B+filename%3DMild_Neurological_Signs_in_FMR1_Premutat.pdf\u0026Expires=1739808232\u0026Signature=UWnlxEi-~IXtOQTV8i6YLsO8SlQWrwEZNFJaeKTi4GyaQJMR7o3aY7oT2o12K7TOQOTsx143kNhxARg3XshxgU~w~PVa2tjsgiaK8pwD0AcTSecdoqvU355aovzdio5LLndkZfPWT9TrkGJN0Wf0xkAnkj1iqr235yV72nydtpSYNc~75vTtTGpU1L~NhtLB3SL8tkYV9CFIRM3O1gioMpORgMZjZyRMKMcMVpSqrmXPhrWcWHze9lfWkz6K6cTXEau9tKzdqaoQu0dzS5c1rxY2wQj83wiWrTkc9p-q9t5ij~d6Q2RU8UDWdUzXpdEBmIfRbLJ26FKk8DPtyUPSBw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795668"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/90795668/Methods_for_detecting_sleepiness"><img alt="Research paper thumbnail of Methods for detecting sleepiness" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/90795668/Methods_for_detecting_sleepiness">Methods for detecting sleepiness</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795668"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795668"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795668; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90795668]").text(description); $(".js-view-count[data-work-id=90795668]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90795668; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90795668']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=90795668]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90795668,"title":"Methods for detecting sleepiness","internal_url":"https://www.academia.edu/90795668/Methods_for_detecting_sleepiness","owner_id":47968559,"coauthors_can_edit":true,"owner":{"id":47968559,"first_name":"Jaime","middle_initials":null,"last_name":"Boero","page_name":"JaimeBoero","domain_name":"marshfieldclinic","created_at":"2016-04-29T09:29:32.998-07:00","display_name":"Jaime Boero","url":"https://marshfieldclinic.academia.edu/JaimeBoero"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795667"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia"><img alt="Research paper thumbnail of Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia" class="work-thumbnail" src="https://attachments.academia-assets.com/94260089/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia">Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia</a></div><div class="wp-workCard_item"><span>Neuroscience Letters</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Respiratory activity and NADH CoQ reductase (complex I) and cytochrome c oxidase (complex IV) act...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Respiratory activity and NADH CoQ reductase (complex I) and cytochrome c oxidase (complex IV) activities were measured in free (non-synaptosomal) mitochondria isolated from cerebral cortex of male Balb/c mice exposed to intermittent hypobaric hypoxia (450 Torr; 4300 m) for 21 days and compared to normoxic (sea level) controls. In the hypoxic we found a 47% reduction of oxygen uptake during state 3 (ADP and substrate present), 12% reduction during state 4 (no ADP present) and 20% reduction in the uncoupled respiration rate with pymvate plus malate as substrates. Respiratory control ratio (RCR) decreased by 24%. No change in the ADP/O ratio was seen. NADH CoQ reductase activity decreased by 30% and cytochrome c oxidase by 17%, suggesting that under conditions of chronic hypoxia, the reductions of mitochondrial respiratory activities are caused, at least in part, by enzymatic alterations of the electron transport chain (complex I and complex IV). The decreased activity of these enzymes could contribute to alterations in neuronal activity by reducing brain energy metabolism during development under conditions of chronic hypoxia.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="288c521b48020d3767ff22096a108069" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260089,"asset_id":90795667,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260089/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795667"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795667"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795667; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=90795667]").text(description); $(".js-view-count[data-work-id=90795667]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 90795667; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='90795667']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "288c521b48020d3767ff22096a108069" } } $('.js-work-strip[data-work-id=90795667]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":90795667,"title":"Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia","internal_url":"https://www.academia.edu/90795667/Reduced_mitochondrial_respiration_in_mouse_cerebral_cortex_during_chronic_hypoxia","owner_id":47968559,"coauthors_can_edit":true,"owner":{"id":47968559,"first_name":"Jaime","middle_initials":null,"last_name":"Boero","page_name":"JaimeBoero","domain_name":"marshfieldclinic","created_at":"2016-04-29T09:29:32.998-07:00","display_name":"Jaime Boero","url":"https://marshfieldclinic.academia.edu/JaimeBoero"},"attachments":[{"id":94260089,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/94260089/thumbnails/1.jpg","file_name":"0304-3940_2895_2911692-p20221115-1-tawpfj.pdf","download_url":"https://www.academia.edu/attachments/94260089/download_file","bulk_download_file_name":"Reduced_mitochondrial_respiration_in_mou.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/94260089/0304-3940_2895_2911692-p20221115-1-tawpfj-libre.pdf?1668486924=\u0026response-content-disposition=attachment%3B+filename%3DReduced_mitochondrial_respiration_in_mou.pdf\u0026Expires=1739808232\u0026Signature=I2GpZatqy6Y2I5E0xuAS-drK42emAtpg94LWt~6msgg7w4ZhdaxeRvh7FyZpgQ58D~tamyVQKbQDaHgge2pMUh1moAnP~SiBuR1tXPr0csa3kwZfg7S5yyZ5xdr9FrVBS78dxRIOm~rav-XAbj7oir-kcAily6yLCTi6pQPMLVpf1hm1LbkUXPAupnRmHsoOVrDfl5xItRzPS5I79Erzz2thCsATeQHKtayWwZkLP0AHJsRTIsGCaWD-t32V5sePvWUprqzN~szf4lpscuYdyxV5YiF5W-heA9IUpiNM66z7nDZtaYuwg5Aquut9A18nqmgTP1EugkTDtuywkNv2GQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795666"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795666/Deletion_of_the_n_terminus_of_murine_map2_by_gene_targeting_disrupts_hippocampal_ca1_neuron_architecture_and_alters_contextual_memory"><img alt="Research paper thumbnail of Deletion of the n-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory" class="work-thumbnail" src="https://attachments.academia-assets.com/94260094/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795666/Deletion_of_the_n_terminus_of_murine_map2_by_gene_targeting_disrupts_hippocampal_ca1_neuron_architecture_and_alters_contextual_memory">Deletion of the n-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory</a></div><div class="wp-workCard_item"><span>Neuroscience</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Microtubule-associated protein-2 (MAP2) is a brain specific A-kinase anchoring protein that targe...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Microtubule-associated protein-2 (MAP2) is a brain specific A-kinase anchoring protein that targets the cyclic AMP-dependent protein kinase holoenzyme (PKA) to microtubules. Phosphorylation of MAP2 by different protein kinases is crucial for neuronal growth. The N-terminus of MAP2 contains the binding site for regulatory subunit II of cAMPdependent protein kinase (PKA-RII␤). Using homologous recombination, we created a mutant line of mice (⌬1-158) that express truncated MAP2 lacking the N-terminal peptide and the PKA binding site. Deletion of the PKA binding site from the MAP2 gene resulted in decreased efficiency of MAP2 phosphorylation. Biochemical and immunohistochemical studies demonstrate major changes in the morphology of hippocampal neurons in ⌬1-158 mice. Behavioral tests indicate that ⌬1-158 mice were impaired (exhibited less conditioned freezing) relative to Wild-Type (WT) controls during a test of contextual, but not during auditory cue, fear conditioning when tested at 8 weeks or 8 months of age. The ⌬1-158 mice displayed a heightened sensitivity to shock at 8 weeks, but not at 8 months of age. We conclude that PKA binding to MAP2 and MAP2 phosphorylation is essential for the selective development of contextual memory.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ab4154566f518d964814c83f032827ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260094,"asset_id":90795666,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260094/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795666"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795666"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795666; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="90795576"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/90795576/Energetic_metabolism_in_mouse_cerebral_cortex_during_chronic_hypoxia"><img alt="Research paper thumbnail of Energetic metabolism in mouse cerebral cortex during chronic hypoxia" class="work-thumbnail" src="https://attachments.academia-assets.com/94260051/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/90795576/Energetic_metabolism_in_mouse_cerebral_cortex_during_chronic_hypoxia">Energetic metabolism in mouse cerebral cortex during chronic hypoxia</a></div><div class="wp-workCard_item"><span>Neuroscience Letters</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We measured the activities of Na 1 K 1 ATPase and of enzymes of the glycolytic pathway, Krebs cyc...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We measured the activities of Na 1 K 1 ATPase and of enzymes of the glycolytic pathway, Krebs cycle, and the respiratory chain in cerebral cortex of mice exposed to chronic hypoxia for three weeks and compared their values with those of sea level controls. There were no differences in Na 1 K 1 ATPase activity or in the activity of glycolytic enzymes. In the Krebs cycle, a 66% increase of succinate dehydrogenase activity was found due to a lower Km. In contrast, respiratory chain cytochrome oxidase activity was reduced by 12% in mice exposed to hypoxia. This suggested that the metabolic demand would be satis®ed despite the respiratory chain depression (cytochrome oxidase), probably due to anaerobic energy production within the mitochondria (succinate dehydrogenase).</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="14cac15ee8b8bd4f33f9d15c03128ad3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":94260051,"asset_id":90795576,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/94260051/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="90795576"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="90795576"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 90795576; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="74170497"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/74170497/Increased_brain_capillaries_in_chronic_hypoxia"><img alt="Research paper thumbnail of Increased brain capillaries in chronic hypoxia" class="work-thumbnail" src="https://attachments.academia-assets.com/82623725/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/74170497/Increased_brain_capillaries_in_chronic_hypoxia">Increased brain capillaries in chronic hypoxia</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain vessels ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The effect of chronic hypobaric hypoxia (28 days, 455 Torr) on the organization of brain vessels was studied in Balb/c mice. In comparison to age-matched controls kept at sea level, emulsion-perfused capillaries in hypoxic mice showed marked dilation in all brain areas studied. Capillary length per unit volume of tissue ( L v) was increased in the cerebellar granular layer, the caudate nucleus, the globus pallidus, the substantia nigra, the superior colliculus, and the dentate gyrus. There was a selective increase of L v in the hippocampus (CA1 strata pyramidale and lacunosum and CA3 strata pyramidale and oriens) and in somatosensory cortex layers V and VI, motor cortex layers II, III, V, and VI, and auditory cortex layers II and III. An increase in capillary surface area per unit volume of tissue was also determined in several brain areas, including layer IV of somatosensory cortex, where L v was not significantly increased. The O2diffusion conductance and [Formula: see text] in th...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dd45cff3dfd753f942d7a74eaf508578" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":82623725,"asset_id":74170497,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/82623725/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="74170497"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="74170497"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 74170497; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="66824390"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/66824390/Identification_of_a_biomarker_for_sleep_drive_in_flies_and_humans"><img alt="Research paper thumbnail of Identification of a biomarker for sleep drive in flies and humans" class="work-thumbnail" src="https://attachments.academia-assets.com/77869080/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/66824390/Identification_of_a_biomarker_for_sleep_drive_in_flies_and_humans">Identification of a biomarker for sleep drive in flies and humans</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences of the United States of America</span><span>, Jan 26, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It is a common experience to sacrifice sleep to meet the demands of our 24-h society. Current est...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It is a common experience to sacrifice sleep to meet the demands of our 24-h society. Current estimates reveal that as a society, we sleep on average 2 h less than we did 40 years ago. This level of sleep restriction results in negative health outcomes and is sufficient to produce cognitive deficits and reduced attention and is associated with increased risk for traffic and occupational accidents. Unfortunately, there is no simple quantifiable marker that can detect an individual who is excessively sleepy before adverse outcomes become evident. To address this issue, we have developed a simple and effective strategy for identifying biomarkers of sleepiness by using genetic and pharmacological tools that dissociate sleep drive from wake time in the model organism Drosophila melanogaster. These studies have identified a biomarker, Amylase, that is highly correlated with sleep drive. More importantly, both salivary Amylase activity and mRNA levels are also responsive to extended waking...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="940e7dc12840221953d083bac13663b4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77869080,"asset_id":66824390,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77869080/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="66824390"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="66824390"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66824390; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24882969"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24882969/Restricted_neuronal_expression_of_ubiquitous_mitochondrial_creatine_kinase_changing_patterns_in_development_and_with_increased_activity"><img alt="Research paper thumbnail of Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: changing patterns in development and with increased activity" class="work-thumbnail" src="https://attachments.academia-assets.com/45203944/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24882969/Restricted_neuronal_expression_of_ubiquitous_mitochondrial_creatine_kinase_changing_patterns_in_development_and_with_increased_activity">Restricted neuronal expression of ubiquitous mitochondrial creatine kinase: changing patterns in development and with increased activity</a></div><div class="wp-workCard_item"><span>Molecular and cellular biochemistry</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Whereas ATP consumption increases with neural activity and is buffered by phosphocreatine (PCr), ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Whereas ATP consumption increases with neural activity and is buffered by phosphocreatine (PCr), it is not known whether PCr synthesis by ubiquitous mitochondrial creatine kinase (uMtCK) supports energy metabolism in all neurons. To explore the possibility that uMtCK expression in neurons is modulated by activity and during development, we used immunocytochemistry to detect uMtCK-containing mitochondria. In the adult brain, subsets of neurons including layer Va pyramidal cells, most thalamic nuclei, cerebellar Purkinje cells, olfactory mitral cells and hippocampal interneurons strongly express uMtCK. uMtCK is transiently expressed by a larger group of neurons at birth. Neurons in all cortical layers express uMtCK at birth (P0), but uMtCK is restricted to layer Va by P12. uMtCK is detected in cerebellar Purkinje cells at birth, but localization to dendrites is only observed after P5 and is maximal on P14. Hippocampal CA1 and CA3 pyramidal neurons contain uMtCK-positive mitochondria a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="94ba48d6e5b0b84ee1f4bb168804a88f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45203944,"asset_id":24882969,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45203944/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24882969"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24882969"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24882969; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24882968"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24882968/Oxidative_myocytes_of_heart_and_skeletal_muscle_express_abundant_sarcomeric_mitochondrial_creatine_kinase"><img alt="Research paper thumbnail of Oxidative myocytes of heart and skeletal muscle express abundant sarcomeric mitochondrial creatine kinase" class="work-thumbnail" src="https://attachments.academia-assets.com/45203928/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24882968/Oxidative_myocytes_of_heart_and_skeletal_muscle_express_abundant_sarcomeric_mitochondrial_creatine_kinase">Oxidative myocytes of heart and skeletal muscle express abundant sarcomeric mitochondrial creatine kinase</a></div><div class="wp-workCard_item"><span>The Histochemical journal</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Sarcomeric mitochondrial creatine kinase catalyzes the reversible transfer of a high energy phosp...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Sarcomeric mitochondrial creatine kinase catalyzes the reversible transfer of a high energy phosphate between ATP and creatine. To study cellular distribution of the kinase, we performed immunocytochemical studies using a peptide antiserum specific for the kinase protein. Our results demonstrated that the sarcomeric mitochondrial creatine kinase gene is abundantly expressed in heart and skeletal muscle, with no protein detected in other tissues examined, including brain, lung, liver, spleen, kidney, bladder, testis, stomach, intestine, and colon. RNA blot study showed that there is no detectable expression of the kinase mRNA in the thymus gland. In heart and skeletal muscle, the kinase protein is expressed in atrial and ventricular cardiomyocytes and a subpopulation of skeletal myofibres. In skeletal muscle, fast myosin heavy chain co-localization studies demonstrated that the sarcomeric mitochondrial creatine kinase is highly expressed in type 1, slow-oxidative and type 2A, fast-ox...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d4db7c8fd59318472447a72ee29a45e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45203928,"asset_id":24882968,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45203928/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24882968"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24882968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24882968; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24882967"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/24882967/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives"><img alt="Research paper thumbnail of Molecular characterization of the creatine kinases and some historical perspectives" class="work-thumbnail" src="https://attachments.academia-assets.com/45203929/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/24882967/Molecular_characterization_of_the_creatine_kinases_and_some_historical_perspectives">Molecular characterization of the creatine kinases and some historical perspectives</a></div><div class="wp-workCard_item"><span>Bioenergetics of the Cell: Quantitative Aspects</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has pa...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Over the last 15 years, molecular characterization of the creatine kinase (CK) gene family has paralleled the molecular revolution of understanding gene structure, function, and regulation. In this review, we present a summary of advances in molecular analysis of the CK gene family with a few vignettes of historical interest. We describe how the muscle CK gene provided an essential model system to examine myogenic regulatory mechanisms, leading to the discovery of the binding site for the MyoD family of basic helix-loop-helix transcription factors essential in skeletal myogenesis and the characterization of the MEF2 family of factors with an A/T rich consensus binding site essential in skeletal myogenesis and cardiogenesis. Cloning and characterization of the four mRNAs and nuclear genes encoding the cytosolic CKs, muscle and brain CKs, and the mitochondrial (Mt) CKs, sarcomeric MtCK and ubiquitous MtCK, has allowed intriguing study of tissue-specific and cell-specific expression of the different CKs and analysis of structural, functional, regulatory, and evolutionary relationships among both the four CK proteins and genes. Current and future studies focus on understanding both cellular energetics facilitated by the CK enzymes, especially energy channelling from the site of production, the mitochondrial matrix and inner membrane, to various cytosolic foci of utilization, and regulation of MtCK gene expression at the cell and tissue-specific level as models of regulation of energy producing genes. (Mol Cell Biochem 184: [153][154][155][156][157][158][159][160][161][162][163][164][165][166][167] 1998)</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6e3e516f432b4c2fc6e9f18365034f44" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45203929,"asset_id":24882967,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45203929/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="24882967"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="24882967"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 24882967; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="24882966"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/24882966/Mitochondrial_%CE%B2_Oxidation_Enzymes_Are_Regionally_Expressed_in_the_Mouse_Brain_1856"><img alt="Research paper thumbnail of Mitochondrial β-Oxidation Enzymes Are Regionally Expressed in the Mouse Brain † 1856" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/24882966/Mitochondrial_%CE%B2_Oxidation_Enzymes_Are_Regionally_Expressed_in_the_Mouse_Brain_1856">Mitochondrial β-Oxidation Enzymes Are Regionally Expressed in the Mouse Brain † 1856</a></div><div class="wp-workCard_item"><span>Pediatric Research</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Mitochondrial fatty acid β-oxidation produces acetyl-CoA that is utilized by the enzymes of the K...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Mitochondrial fatty acid β-oxidation produces acetyl-CoA that is utilized by the enzymes of the Kreb&#x27;s cycle in the generation of NADH and FADH 2. 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