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/_internal/cimg!0/cxh6orthphsicz5djo5ck56yn5ks9pd.jpeg 768w, /_internal/cimg!0/qv4p448pri8e9fsjavyzvnljsjdinvs.jpeg 1024w, /_internal/cimg!0/8a86o3m16p28qde1vkg8fz5ie4bihey.jpeg 1280w, /_internal/cimg!0/2kdyfz7e0z0fff84sd3utnrhq8anlcy.jpeg 1400w, /_internal/cimg!0/hz9japtj66ou91r4l26a7h0qikssskl.jpeg 1600w, /_internal/cimg!0/8e82ofpw1haleo50a5rxzwpgygup1nn.jpeg 2048w, /_internal/cimg!0/19870gtb8i2ej3aq33uqqqt90arymsf.jpeg 2500w" src="data:image/gif;base64,R0lGODlhAQABAAAAADs="><figcaption class="">漏 Universit盲t Bielefeld</figcaption></figure></a> <p>Die Kenntnis der dreidimensionalen Struktur von Molek眉len ist essentiell zum Verst盲ndnis ihrer Funktion. Wir bestimmen die Raumstruktur von Proteinen und makromolekularen Komplexen mit Hilfe der R枚ntgenkristallographie. Zur funktionellen Charakterisierung verwenden wir biochemische und zellbiologische Methoden.</p> <p>Unser Hauptinteresse gilt bakteriellen Virulenzfaktoren und deren Wechselwirkung mit dem Wirt. Aktuell untersuchen wir Proteine des Yersinia enterocolitica Typ III Sekretionssystems und des Helicobacter pylori Typ IV Sekretionssystems. Daneben versuchen wir auf Basis von Kristallstrukturen zu verstehen, wie das Invasionsprotein InlB aus Listeria monocytogenes die menschliche Rezeptor Tyrosinkinase MET aktiviert.</p> </div></div></div></div></section></div></main><div class="ubf-scrollToTop" data-ubf-component="ShowOnScroll" data-ubf-visibility-treshhold="20"><a class="ubf-button ubf-button--scrollToTop" data-ubf-component="ShowOnScroll" data-ubf-visibility-treshhold="20" href="#top"><span data-type="svg"><canvas height="22" width="17"></canvas><svg aria-hidden="true" focusable="false" viewBox="0 0 17 22"><use xlink:href="#triangle-right" /></svg></span><span class="ubf-button__label">Zum Seitenanfang</span></a></div></div><footer class="ubf-body__footer ubf-footer" data-ubf-footer="" id="footer"><div class="ubf-footer__content"><nav aria-label="social links" class="ubf-footer__menu ubf-footer__menu--social"> <ul class="ubf-footer__menuItems"> <li class="ubf-footer__menuItem ubf-footer__menuItem--facebook"><a 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