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KEGG ENZYME: 1.14.12.15
<!doctype html> <html><head> <title>KEGG ENZYME: 1.14.12.15</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1732424311"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1732424311"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1732424311" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « 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form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="683"><tr><td width=70><a href="/kegg/kegg2.html"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg2.gif"></a></td><td> </td><td><a name="enzyme:1.14.12.15"></a><font class="title2">ENZYME: 1.14.12.15</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_enzyme.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/kegg-bin/search_htext" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr2 w1"> <table width="650" class="w2"> <tr><th class="th20 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td20 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">EC 1.14.12.15 Enzyme <br> </span></code></td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td21 defd"><div class="cel"><div class="cel">terephthalate 1,2-dioxygenase;<br> benzene-1,4-dicarboxylate 1,2-dioxygenase;<br> 1,4-dicarboxybenzoate 1,2-dioxygenase<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td20 defd"><div class="cel">Oxidoreductases;<br> Acting on paired donors, with incorporation or reduction of molecular oxygen;<br> With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor<br> <button class="btn" onclick="location.href='/brite/ko01000+1.14.12.15';return false;">BRITE hierarchy</button></div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Sysname</span></th> <td class="td21 defd"><div class="cel">benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Reaction(IUBMB)</span></th> <td class="td20 defd"><div class="cel">terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ [RN:<a href="/entry/R05148">R05148</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reaction(KEGG)</span></th> <td class="td21 defd"><div class="cel"><a href="/entry/R05148">R05148</a><br> <button class="btn" onclick="location.href='/entry/R05148';return false;">Reaction</button></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Substrate</span></th> <td class="td20 defd"><div class="cel">terephthalate [CPD:<a href="/entry/C06337">C06337</a>];<br> NADH [CPD:<a href="/entry/C00004">C00004</a>];<br> H+ [CPD:<a href="/entry/C00080">C00080</a>];<br> O2 [CPD:<a href="/entry/C00007">C00007</a>]<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td21 defd"><div class="cel"><div class="cel">(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate [CPD:<a href="/entry/C06318">C06318</a>];<br> NAD+ [CPD:<a href="/entry/C00003">C00003</a>]<br> </div></div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td20 defd"><div class="cel">Has been shown to contain a Rieske [2Fe-2S] cluster<br> </div></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">History</span></th> <td class="td21 defd"><div class="cel">EC 1.14.12.15 created 1999<br> </div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec00624+1.14.12.15">ec00624</a> </span></td><td>Polycyclic aromatic hydrocarbon degradation</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec01100+1.14.12.15">ec01100</a> </span></td><td>Metabolic pathways</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/ec01120+1.14.12.15">ec01120</a> </span></td><td>Microbial metabolism in diverse environments</td></tr></table></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td21 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K18074">K18074</a> </span></td><td>terephthalate 1,2-dioxygenase oxygenase component alpha subunit</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/K18075">K18075</a> </span></td><td>terephthalate 1,2-dioxygenase oxygenase component beta subunit</td></tr></table></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Genes</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+PARK+ec:1.14.12.15" target="_blank">PARK</a>: </span></td><td>LSG25_11505</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+RHOB+ec:1.14.12.15" target="_blank">RHOB</a>: </span></td><td>HTY51_11710</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+VPD+ec:1.14.12.15" target="_blank">VPD</a>: </span></td><td>VAPA_2c09660 VAPA_2c09670</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+CTT+ec:1.14.12.15" target="_blank">CTT</a>: </span></td><td>CtCNB1_1493 CtCNB1_1494</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+CTES+ec:1.14.12.15" target="_blank">CTES</a>: </span></td><td>O987_22455 O987_22460</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+RTA+ec:1.14.12.15" target="_blank">RTA</a>: </span></td><td>Rta_16740 Rta_16750</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+HYB+ec:1.14.12.15" target="_blank">HYB</a>: </span></td><td>Q5W_19730 Q5W_19735</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+HTN+ec:1.14.12.15" target="_blank">HTN</a>: </span></td><td>KI616_03585</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+HCZ+ec:1.14.12.15" target="_blank">HCZ</a>: </span></td><td>G9Q37_15485</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+HYY+ec:1.14.12.15" target="_blank">HYY</a>: </span></td><td>JNX00_08635 JNX00_14775 JNX00_14780</td></tr></table><input type="hidden" name="query" form="form1" value="PARK RHOB VPD CTT CTES RTA HYB HTN HCZ HYY"><input type="hidden" name="htext" form="form1" value="br08601.keg"><input type="hidden" name="option" form="form1" value="-a"><button class="btn" onclick="javascript:go_taxonomy(document.form1,{"action":"/kegg-bin/search_htext"});return false;">Taxonomy</button></td></tr> <tr><th class="th21 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td21 defd"><div class="cel">1 [PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/7961417">7961417</a>]</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td20 repd"><div class="cel">Schlafli HR, Weiss MA, Leisinger T, Cook AM</div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td21 repd"><div class="cel">Terephthalate 1,2-dioxygenase system from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.</div></td></tr> <tr><th class="th20 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td20 repd"><div class="cel">J Bacteriol 176:6644-52 (1994)<br>DOI:<a href="https://doi.org/10.1128/JB.176.21.6644-6652.1994">10.1128/JB.176.21.6644-6652.1994</a></div></td></tr> <tr><th class="th21 rept tal vtop"><span class="nowrap"> Sequence</span></th> <td class="td21 repd"><div class="cel">[ctt:<a href="/entry/ctt:CtCNB1_1493">CtCNB1_1493</a> <a href="/entry/ctt:CtCNB1_1494">CtCNB1_1494</a>]</div></td></tr> <tr><th class="th20 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td20 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExplorEnz - The Enzyme Database: </span></td><td><a href="https://www.enzyme-database.org/query.php?ec=1.14.12.15">1.14.12.15</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">IUBMB Enzyme Nomenclature: </span></td><td><a href="https://iubmb.qmul.ac.uk/enzyme/EC1/14/12/15.html">1.14.12.15</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ExPASy - ENZYME nomenclature database: </span></td><td><a href="https://enzyme.expasy.org/EC/1.14.12.15">1.14.12.15</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">UM-BBD (Biocatalysis/Biodegradation Database): </span></td><td><a href="http://eawag-bbd.ethz.ch/servlets/pageservlet?ptype=e&ECcode=1.14.12.15">1.14.12.15</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">BRENDA, the Enzyme Database: </span></td><td><a href="https://www.brenda-enzymes.info/enzyme.php?ecno=1.14.12.15">1.14.12.15</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>162032-76-0</td></tr></table></td></tr> <tr><th class="th21 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td21 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?enzyme+1.14.12.15';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>