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So far, there are no reliable markers available to assess the hypoxic cerebral damage and the resulting prognosis during the immediate postnatal" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/30851332/Placental_HIFs_as_markers_of_cerebral_hypoxic_distress_in_fetal_mice" /> <meta property="og:title" content="Placental HIFs as markers of cerebral hypoxic distress in fetal mice" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="duced oxygen supply during the pre-and perinatal period often leads to acquired neonatal brain damage. So far, there are no reliable markers available to assess the hypoxic cerebral damage and the resulting prognosis during the immediate postnatal" /> <meta property="article:author" content="https://independent.academia.edu/XeniaAntoniou" /> <meta name="description" content="duced oxygen supply during the pre-and perinatal period often leads to acquired neonatal brain damage. 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window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":30851332,"created_at":"2017-01-10T02:23:44.258-08:00","from_world_paper_id":160247838,"updated_at":"2024-11-27T23:02:34.882-08:00","_data":{"ai_title_tag":"Placental HIFs as Indicators of Fetal Brain Hypoxia","grobid_abstract":"duced oxygen supply during the pre-and perinatal period often leads to acquired neonatal brain damage. So far, there are no reliable markers available to assess the hypoxic cerebral damage and the resulting prognosis during the immediate postnatal period. Thus we aimed to determine whether the hypoxia-inducible transcription factors (HIF-1 and HIF-2) and/or their target genes in the placenta represent reliable indicators of hypoxic distress of the developing brain during systemic hypoxia at the end of gestation. To this end, pregnant mice were exposed to systemic hypoxia (inspired O2 fraction: 6%, 6 h) at gestational day 20. This hypoxic exposure significantly increased HIF-1␣ and HIF-2␣ protein levels in brain and placental tissue. Compared with normoxic controls, an increase of HIF-1␣-immunoreactive neurons and HIF-2␣-positive glial cells and vascular endothelial cells was observed in hypoxic cerebral cortex and hippocampus. In placenta, HIF-1␣ and HIF-2␣ were expressed in labyrinthine layer with increased staining intensity during hypoxia compared with normoxia. Significant upregulation of VEGF mRNA and protein in brain and placenta, as well as erythropoietin protein in placenta, indicated activity of the HIF system upon fetal hypoxia. Notably, hypoxia did not affect expression of the HIF target genes inducible nitric oxide synthase and GLUT-1. Taken together, at gestational day 20, systemic hypoxia led to upregulation of HIF-␣ in mouse brain that was temporally paralleled in placenta, implying that ␣-subunits of both HIF-1 and HIF-2 are indeed early markers of hypoxic distress in vivo. If our data reflect the situation in humans, analysis of the placenta will allow early identification of the hypoxic brain distress occurring near birth. developing brain; mouse placenta; vascular endothelial growth factor; erythropoietin; inducible nitric oxide synthase","publication_date":"2008,,","publication_name":"AJP: Regulatory, Integrative and Comparative Physiology","grobid_abstract_attachment_id":"51278872"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Placental HIFs as markers of cerebral hypoxic distress in fetal mice","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [58719838]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":51278872,"attachmentType":"pdf"}"><img alt="First page of “Placental HIFs as markers of cerebral hypoxic distress in fetal mice”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/51278872/mini_magick20190125-27197-ldzftt.png?1548483610" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Placental HIFs as markers of cerebral hypoxic distress in fetal mice</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="58719838" href="https://independent.academia.edu/XeniaAntoniou"><img alt="Profile image of Xenia Antoniou" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Xenia Antoniou</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2008, AJP: Regulatory, Integrative and Comparative Physiology</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">11 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 30851332; 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if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">duced oxygen supply during the pre-and perinatal period often leads to acquired neonatal brain damage. So far, there are no reliable markers available to assess the hypoxic cerebral damage and the resulting prognosis during the immediate postnatal period. Thus we aimed to determine whether the hypoxia-inducible transcription factors (HIF-1 and HIF-2) and/or their target genes in the placenta represent reliable indicators of hypoxic distress of the developing brain during systemic hypoxia at the end of gestation. To this end, pregnant mice were exposed to systemic hypoxia (inspired O2 fraction: 6%, 6 h) at gestational day 20. This hypoxic exposure significantly increased HIF-1␣ and HIF-2␣ protein levels in brain and placental tissue. Compared with normoxic controls, an increase of HIF-1␣-immunoreactive neurons and HIF-2␣-positive glial cells and vascular endothelial cells was observed in hypoxic cerebral cortex and hippocampus. In placenta, HIF-1␣ and HIF-2␣ were expressed in labyrinthine layer with increased staining intensity during hypoxia compared with normoxia. Significant upregulation of VEGF mRNA and protein in brain and placenta, as well as erythropoietin protein in placenta, indicated activity of the HIF system upon fetal hypoxia. Notably, hypoxia did not affect expression of the HIF target genes inducible nitric oxide synthase and GLUT-1. Taken together, at gestational day 20, systemic hypoxia led to upregulation of HIF-␣ in mouse brain that was temporally paralleled in placenta, implying that ␣-subunits of both HIF-1 and HIF-2 are indeed early markers of hypoxic distress in vivo. If our data reflect the situation in humans, analysis of the placenta will allow early identification of the hypoxic brain distress occurring near birth. developing brain; mouse placenta; vascular endothelial growth factor; erythropoietin; inducible nitric oxide synthase</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":51278872,"attachmentType":"pdf","workUrl":"https://www.academia.edu/30851332/Placental_HIFs_as_markers_of_cerebral_hypoxic_distress_in_fetal_mice"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":51278872,"attachmentType":"pdf","workUrl":"https://www.academia.edu/30851332/Placental_HIFs_as_markers_of_cerebral_hypoxic_distress_in_fetal_mice"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="51278872" data-landing_url="https://www.academia.edu/30851332/Placental_HIFs_as_markers_of_cerebral_hypoxic_distress_in_fetal_mice" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="86042663" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/86042663/Late_gestational_systemic_hypoxia_leads_to_a_similar_early_gene_response_in_mouse_placenta_and_developing_brain">Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32951349" href="https://independent.academia.edu/ReginaTrollmann">Regina Trollmann</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Late-gestational intrauterine hypoxia represents a well-known risk factor of acquired perinatal brain injury. Cell type and age-specific sensitivity of hypoxia-responsive genes to low-oxygen partial pressure is to be considered in the screening for early indicators of fetoplacental tissue hypoxia. To identify early hypoxia-induced alterations in gene expression during late-gestational hypoxia (6% O2, 6 h; gestational day 20) we compared primary mouse placenta and brain transcriptomes using high-density oligonucleotide microarrays. Upregulation of candidate marker genes for hypoxia was confirmed by quantitative RT-PCR and immunohistochemistry. Both developing brain and placenta were highly responsive to systemic hypoxia at the level of gene expression involving hypoxia-inducible transcription factor (HIF)-dependent genes and immediate early genes (IEG) (Fos, Jun, Egr1, Bhlhb2), apoptosis-promoting factors (Bnip3, Dusp1, Ier3) that were all upregulated, and genes modulating RNA bindin...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain","attachmentId":90582310,"attachmentType":"pdf","work_url":"https://www.academia.edu/86042663/Late_gestational_systemic_hypoxia_leads_to_a_similar_early_gene_response_in_mouse_placenta_and_developing_brain","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/86042663/Late_gestational_systemic_hypoxia_leads_to_a_similar_early_gene_response_in_mouse_placenta_and_developing_brain"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="22893273" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/22893273/Regulation_of_Hypoxia_Inducible_Factors_HIF_in_Hypoxia_and_Normoxia_During_Placental_Development">Regulation of Hypoxia Inducible Factors (HIF) in Hypoxia and Normoxia During Placental Development</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44373582" href="https://independent.academia.edu/KerryRichard">Kerry Richard</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Placenta, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">During the first trimester of pregnancy the human placenta develops in an hypoxic environment caused by the occlusion of uterine spiral arterioles by extravillous trophoblasts (EVT). This period of low oxygen tension is crucial for successful pregnancy. In low oxygen environments, Hypoxia Inducible Factors (HIF) are the main regulators in the transcription of a number of genes. Target genes can induce anaerobic processes, reducing oxygen consumption, or promote angiogenesis, which establishes and enhances the vascular environment. The HIFs can function throughout all stages of placental differentiation and growth both in normal and pathological pregnancies (compromised by hypoxia/ischemia). Interestingly, HIFs respond to a multitude of changes during pregnancy, including 1) low oxygen, 2) renineangiotensin system (RAS), 3) cytokines, and 4) growth factors, all of which regulate placental function. This review explores oxygen-dependent and oxygen-independent regulation and the role of HIF in placental development and differentiation.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Regulation of Hypoxia Inducible Factors (HIF) in Hypoxia and Normoxia During Placental Development","attachmentId":43432809,"attachmentType":"pdf","work_url":"https://www.academia.edu/22893273/Regulation_of_Hypoxia_Inducible_Factors_HIF_in_Hypoxia_and_Normoxia_During_Placental_Development","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/22893273/Regulation_of_Hypoxia_Inducible_Factors_HIF_in_Hypoxia_and_Normoxia_During_Placental_Development"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="5693868" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/5693868/Human_Placental_Hypoxia_Inducible_Factor1%CE%B1_Expression_Correlates_with_Clinical_Outcomes_in_Chronic_Hypoxia_in_Vivo">Human Placental Hypoxia-Inducible Factor1α Expression Correlates with Clinical Outcomes in Chronic Hypoxia in Vivo</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8234700" href="https://unisi.academia.edu/francescaietta">francesca ietta</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Pathology, 2007</p><p class="ds-related-work--abstract ds2-5-body-sm">Placental hypoxia is causally implicated in fetal growth restriction and preeclampsia , with both occurring more frequently at high altitude (>2700 m; HA). The nuclear transcription factor hypoxia-inducible factor (HIF) may facilitate placental oxygen transport at HA by increasing erythropoiesis and placental angiogenesis. We therefore investigated HIF expression and its regulatory mechanisms in placentas from normal pregnancies at high (3100 m), moderate (1600 m) , and sea level (75 m) altitudes. Moderate-altitude and sea level placentas did not differ , but HIF-1␣ and the von Hippel-Lindau tumor suppressor protein were overexpressed in HA placentas. The ability of von Hippel-Lindau tumor suppressor protein to form the E3 ubiquitin protein ligase complex , required for HIF-1␣ degradation , was unaltered in HA placentas. mRNA for factor-inhibiting HIF , a negative modulator of HIF-1␣ transactivation , was increased, but protein levels were diminished. Elevated HIF-1␣ likely contributed to the significant increase we report in HIF-1␣ downstream target proteins, transforming growth factor ␤3 in the placenta, and vascular endothelial growth factor and erythropoietin in the maternal circulation. These circulating markers and lowered birth to placental weight ratios correlated with increased HIF-1␣, thereby linking molecular and systemic physiolog-ical data. The HA response to chronic hypoxia resembles preeclampsia in several aspects, illustrating the utility of the HA model in understanding placental pathologies.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Human Placental Hypoxia-Inducible Factor1α Expression Correlates with Clinical Outcomes in Chronic Hypoxia in Vivo","attachmentId":49178308,"attachmentType":"pdf","work_url":"https://www.academia.edu/5693868/Human_Placental_Hypoxia_Inducible_Factor1%CE%B1_Expression_Correlates_with_Clinical_Outcomes_in_Chronic_Hypoxia_in_Vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/5693868/Human_Placental_Hypoxia_Inducible_Factor1%CE%B1_Expression_Correlates_with_Clinical_Outcomes_in_Chronic_Hypoxia_in_Vivo"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="56806251" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56806251/The_role_of_hypoxia_inducible_transcription_factors_in_the_hypoxic_neonatal_brain">The role of hypoxia-inducible transcription factors in the hypoxic neonatal brain</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32951349" href="https://independent.academia.edu/ReginaTrollmann">Regina Trollmann</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain and Development, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Hypoxia-inducible transcription factors (HIF)-1 and HIF-2, composed of an oxygen-dependent a-subunit and a constitutive bsubunit, have been characterized as the most important regulators of oxygen homeostasis during physiological and pathological conditions. During embryonic, fetal and postnatal brain development, HIFs and specific HIF target genes are involved in early and highly active maturational processes by modulating cell differentiation, vascular development, angiogenesis and metabolic homeostasis. Under hypoxic conditions, activation of the HIF system reflects an immediate and cell-specific response to acute brain hypoxia. In a complementary fashion, both HIF-1 and HIF-2 modulate cerebral hypoxic stress responses and activate endogenous neuroprotective systems during acute and late stages of hypoxic/ischemic (HI) damage of the developing brain. Therefore, HIFs and their specific target genes that are expressed during brain injury are of particular interest for future diagnostic and therapeutic options in HI injury of the developing nervous system.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The role of hypoxia-inducible transcription factors in the hypoxic neonatal brain","attachmentId":72011461,"attachmentType":"pdf","work_url":"https://www.academia.edu/56806251/The_role_of_hypoxia_inducible_transcription_factors_in_the_hypoxic_neonatal_brain","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/56806251/The_role_of_hypoxia_inducible_transcription_factors_in_the_hypoxic_neonatal_brain"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="95730430" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/95730430/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia">HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32903116" href="https://independent.academia.edu/DonnaFerriero">Donna Ferriero</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Developmental Neuroscience, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Evidence suggests that the activation of the transcription factor hypoxia-inducible factor 1α (HIF-1α) may promote cell survival in hypoxic or ischemic brain. To help understand the role of HIF-1α in neonatal hypoxic-ischemic brain injury, mice with conditional neuron-specific inactivation of HIF-1α underwent hypoxia-ischemia (HI). Mice heterozygous for Cre recombinase under the control of the calcium/calmodulin-dependent kinase II promoter were bred with homozygous ‘floxed’ HIF-1α transgenic mice. The resulting litters produced mice with a forebrain predominant neuronal deletion of HIF-1α (HIF-1αΔ/Δ), as well as littermates without the deletion. In order to verify reduction of HIF-1α at postnatal day 7, HIF-1αΔ/Δ and wild-type mice were exposed to a hypoxic stimulus (8% oxygen) or room air for 1 h, followed by immediate collection of brain cortices for determination of HIF-1α expression. Results of Western blotting of mouse cortices exposed to hypoxia stimulus or room air confirmed...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"HIF-1α-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia","attachmentId":97831555,"attachmentType":"pdf","work_url":"https://www.academia.edu/95730430/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/95730430/HIF_1%CE%B1_Deficient_Mice_Have_Increased_Brain_Injury_after_Neonatal_Hypoxia_Ischemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="19792182" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19792182/Oxygen_treatment_after_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1_and_its_downstream_target_genes">Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1 and its downstream target genes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40523166" href="https://independent.academia.edu/JulianCahill">Julian Cahill</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Applied Physiology, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Oxygen treatment after experimental hypoxiaischemia in neonatal rats alters the expression of HIF-1␣ and its downstream target genes. cently, mounting evidence has emerged to suggest that hyperbaric oxygenation (HBOT)-induced neuroprotection after experimental global ischemia and subarachnoid hemorrhage entails a decrease in the expression of hypoxia-inducible factor-1␣ (HIF-1␣). Therefore, the purpose of this study was to test the hypothesis that oxygeninduced neuroprotection after neonatal hypoxia-ischemia involves alterations in the expression of HIF-1␣. Seven-day-old rat pups were subjected to unilateral carotid artery ligation followed by 2 h of hypoxia (8% O 2 at 37°C). Pups were then treated with HBOT (2.5 ATA) or normobaric oxygenation treatment (NBOT) for 2 h. The expression and phosphorylation status of HIF-1␣ was evaluated at intervals up to 24 h after the insult, as was the expression of glucose transporter (GLUT)-1, GLUT-3, lactate dehydrogenase (LDH), aldolase (Ald), and p53. The protein-protein interaction of HIF-1␣ and p53 was also examined. An elevated expression of HIF-1␣, GLUT-1, GLUT-3, Ald, and LDH was observed after the insult. An increase in the dephosphorylated form of HIF-1␣ was followed by an increase in the association of HIF-1␣ with p53 and an increase in p53 levels. Both HBOT and NBOT reduced the elevated expression of HIF-1␣ and decreased its dephosphorylated form. Furthermore, both treatments promoted a transient increase in the expression of GLUT-1, GLUT-3, LDH, and Ald, while decreasing the HIF-1␣-p53 interaction and decreasing the expression of p53. Therefore, the alteration of the HIF-1␣ phenotype by a single oxygen treatment may be one of the underlying mechanisms for the observed oxygen-induced neuroprotection seen when oxygen is administered after a neonatal hypoxicischemic insult. brain; hyperbaric oxygenation; hypoxia-inducible factor-1␣; normobaric oxygenation; neonatal hypoxia-ischemia</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1 and its downstream target genes","attachmentId":42016494,"attachmentType":"pdf","work_url":"https://www.academia.edu/19792182/Oxygen_treatment_after_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1_and_its_downstream_target_genes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/19792182/Oxygen_treatment_after_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1_and_its_downstream_target_genes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="19792179" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19792179/Oxygen_treatment_following_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1_alpha_and_its_downstream_target_genes">Oxygen treatment following experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1 alpha and its downstream target genes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40523166" href="https://independent.academia.edu/JulianCahill">Julian Cahill</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Applied …, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Recently, mounting evidence has emerged to suggest that hyperbaric oxygenation (HBOT)-induced neuroprotection following experimental global ischemia and subarachnoid hemorrhage entails a decrease in the expression of hypoxia-inducible factor-1 (HIF-1 ). Therefore, the purpose of this study was to test the hypothesis that oxygen-induced neuroprotection following neonatal hypoxia-ischemia involves alterations in the expression of HIF-1 . Seven-dayold rat pups were subjected to unilateral carotid artery ligation followed by 2hrs of hypoxia (8% O2 at 37°C). The administration of HBOT (2.5ATA) or normobaric oxygenation treatment (NBOT) for 2hrs. The expression and phosphorylation status of HIF-1 was evaluated at intervals up to 24hrs after the insult, as was the expression of glucose transporter (Glut)-1, Glut-3, LDH, ALD, and p53. The protein-protein interaction of HIF-1 and p53 was also examined.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oxygen treatment following experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1 alpha and its downstream target genes","attachmentId":42016520,"attachmentType":"pdf","work_url":"https://www.academia.edu/19792179/Oxygen_treatment_following_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1_alpha_and_its_downstream_target_genes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/19792179/Oxygen_treatment_following_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1_alpha_and_its_downstream_target_genes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="55085228" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/55085228/Preserved_placental_oxygenation_and_development_during_severe_systemic_hypoxia">Preserved placental oxygenation and development during severe systemic hypoxia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36165036" href="https://independent.academia.edu/MaxGassmann">Max Gassmann</a></div><p class="ds-related-work--metadata ds2-5-body-xs">AJP: Regulatory, Integrative and Comparative Physiology, 2005</p><p class="ds-related-work--abstract ds2-5-body-sm">Local tissue oxygenation profoundly influences placental development. To elucidate the impact of hypoxia on cellular and molecular adaptation in vivo, pregnant mice at embryonic days 7.5–11.5 were exposed to reduced environmental oxygen (6–7% O2) for various periods of time. Hypoxia-inducible factor (HIF)-1α mRNA was highly expressed in the placenta, whereas HIF-2α was predominantly found in the decidua, indicating that HIF-1 is a relevant oxygen-dependent factor involved in placental development. During severe hypoxia, HIF-1α protein was strongly induced in the periphery but, however, not in the labyrinth layer of the placenta. Accordingly, no indication for tissue hypoxia in this central area was detected with 2-(2-nitro-1 H-imidazol-1-yl)- N-(2,2,3,3,3-pentafluoropropyl)acetamide staining and VEGF expression as hypoxic markers. The absence of significant tissue hypoxia was reflected by preserved placental architecture and trophoblast differentiation. In the search for mechanisms ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Preserved placental oxygenation and development during severe systemic hypoxia","attachmentId":71128317,"attachmentType":"pdf","work_url":"https://www.academia.edu/55085228/Preserved_placental_oxygenation_and_development_during_severe_systemic_hypoxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/55085228/Preserved_placental_oxygenation_and_development_during_severe_systemic_hypoxia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="111658974" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111658974/Oxygen_treatment_after_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1%CE%B1_and_its_downstream_target_genes">Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1α and its downstream target genes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40523166" href="https://independent.academia.edu/JulianCahill">Julian Cahill</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Applied Physiology, 2006</p><p class="ds-related-work--abstract ds2-5-body-sm">Oxygen treatment after experimental hypoxiaischemia in neonatal rats alters the expression of HIF-1␣ and its downstream target genes.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression of HIF-1α and its downstream target genes","attachmentId":109131491,"attachmentType":"pdf","work_url":"https://www.academia.edu/111658974/Oxygen_treatment_after_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1%CE%B1_and_its_downstream_target_genes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/111658974/Oxygen_treatment_after_experimental_hypoxia_ischemia_in_neonatal_rats_alters_the_expression_of_HIF_1%CE%B1_and_its_downstream_target_genes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="13495083" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13495083/The_role_and_regulation_of_hypoxia_inducible_factor_1%CE%B1_expression_in_brain_development_and_neonatal_hypoxic_ischemic_brain_injury">The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32700579" href="https://umcutrecht.academia.edu/FlorisGroenendaal">Floris Groenendaal</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research Reviews, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">During neonatal hypoxic-ischemic brain injury, activation of transcription of a series of genes is induced to stimulate erythropoiesis, anti-apoptosis, apoptosis, necrosis and angiogenesis. A key factor mediating these gene transcriptions is hypoxia-inducible factor-1α (HIF-1α). During hypoxia, HIF-1α protein is stabilized and heterodimerizes with HIF-1β to form HIF-1, subsequently regulating the expression of target genes. HIF-1α participates in early brain development and proliferation of neuronal precursor cells. Under pathological conditions, HIF-1α is known to play an important role in neonatal hypoxic-ischemic brain injury: on the one hand, HIF-1α has neuroprotective effects whereas it can also have neurotoxic effects. HIF-1α regulates the transcription of erythropoietin (EPO), which induces several pathways associated with neuroprotection. HIF-1α also promotes the expression of vascular endothelial cell growth factor (VEGF), which is related to neovascularization in hypoxic-ischemic brain areas. In addition, HIF-1α has an anti-apoptotic effect by increasing the expression of anti-apoptotic factors such as EPO during mild hypoxia. The neurotoxic effects of HIF-1α are represented by its participation in the apoptotic process by increasing the stability of the tumor suppressor protein p53 during severe hypoxia. Moreover, HIF-1α plays a role in cell necrosis, by interacting with calcium and calpain. HIF-1α can also exacerbate brain edema via increasing the permeability of a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m w w w . e l s e v i e r . c o m / l o c a t e / b r a i n r e s r e v the blood-brain barrier (BBB). Given these properties, HIF-1α has both neuroprotective and neurotoxic effects after hypoxia-ischemia. These events are cell type specific and related to the severity of hypoxia. Unravelling of the complex functions of HIF-1α may be important when designing neuroprotective therapies for hypoxic-ischemic brain injury.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury","attachmentId":45271038,"attachmentType":"pdf","work_url":"https://www.academia.edu/13495083/The_role_and_regulation_of_hypoxia_inducible_factor_1%CE%B1_expression_in_brain_development_and_neonatal_hypoxic_ischemic_brain_injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13495083/The_role_and_regulation_of_hypoxia_inducible_factor_1%CE%B1_expression_in_brain_development_and_neonatal_hypoxic_ischemic_brain_injury"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":51278872,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":51278872,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_51278872" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="21561811" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21561811/Hypoxic_preconditioning_protection_is_eliminated_in_HIF_1%CE%B1_knockout_mice_subjected_to_neonatal_hypoxia_ischemia">Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia–ischemia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42679799" href="https://independent.academia.edu/SheldonAnn">Ann Sheldon</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pediatric Research, 2014</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia–ischemia","attachmentId":42073291,"attachmentType":"pdf","work_url":"https://www.academia.edu/21561811/Hypoxic_preconditioning_protection_is_eliminated_in_HIF_1%CE%B1_knockout_mice_subjected_to_neonatal_hypoxia_ischemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/21561811/Hypoxic_preconditioning_protection_is_eliminated_in_HIF_1%CE%B1_knockout_mice_subjected_to_neonatal_hypoxia_ischemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="107812554" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/107812554/Molecular_Pathways_of_Altered_Brain_Development_in_Fetuses_Exposed_to_Hypoxia">Molecular Pathways of Altered Brain Development in Fetuses Exposed to Hypoxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="96565287" href="https://independent.academia.edu/DagmaraFilipeckaTyczka">Dagmara Filipecka-Tyczka</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Molecular Sciences</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular Pathways of Altered Brain Development in Fetuses Exposed to Hypoxia","attachmentId":106372187,"attachmentType":"pdf","work_url":"https://www.academia.edu/107812554/Molecular_Pathways_of_Altered_Brain_Development_in_Fetuses_Exposed_to_Hypoxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/107812554/Molecular_Pathways_of_Altered_Brain_Development_in_Fetuses_Exposed_to_Hypoxia"><span 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="13862088" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13862088/Hypoxia_activates_the_human_placental_vascular_endothelial_growth_factor_system_in_vitro_and_in_vivo_Up_regulation_of_vascular_endothelial_growth_factor_in_clinically_relevant_hypoxic_ischemia_in_birth_asphyxia">Hypoxia activates the human placental vascular endothelial growth factor system in vitro and in vivo: Up-regulation of vascular endothelial growth factor in clinically relevant hypoxic ischemia in birth asphyxia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32951349" href="https://independent.academia.edu/ReginaTrollmann">Regina Trollmann</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Obstetrics and Gynecology, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hypoxia activates the human placental vascular endothelial growth factor system in vitro and in vivo: Up-regulation of vascular endothelial growth factor in clinically relevant hypoxic ischemia in birth asphyxia","attachmentId":44867442,"attachmentType":"pdf","work_url":"https://www.academia.edu/13862088/Hypoxia_activates_the_human_placental_vascular_endothelial_growth_factor_system_in_vitro_and_in_vivo_Up_regulation_of_vascular_endothelial_growth_factor_in_clinically_relevant_hypoxic_ischemia_in_birth_asphyxia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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ds2-5-body-sm ds2-5-body-link" data-author-id="9851264" href="https://independent.academia.edu/jadhavvikram">vikram jadhav</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury","attachmentId":48914844,"attachmentType":"pdf","work_url":"https://www.academia.edu/6329384/HIF_1_alpha_inhibition_ameliorates_neonatal_brain_damage_after_hypoxic_ischemic_injury","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" 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class="ds-related-work--metadata ds2-5-body-xs">Annals of Neurology, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain","attachmentId":45333804,"attachmentType":"pdf","work_url":"https://www.academia.edu/13449499/Role_of_hypoxia_inducible_factor_1_in_hypoxia_induced_ischemic_tolerance_in_neonatal_rat_brain","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13449499/Role_of_hypoxia_inducible_factor_1_in_hypoxia_induced_ischemic_tolerance_in_neonatal_rat_brain"><span 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js-related-work-sidebar-card" data-collection-position="7" data-entity-id="56806256" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/56806256/HIF_1_regulated_vasoactive_systems_are_differentially_involved_in_acute_hypoxic_stress_responses_of_the_developing_brain_of_newborn_mice_and_are_not_affected_by_levetiracetam">HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32951349" href="https://independent.academia.edu/ReginaTrollmann">Regina Trollmann</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Brain Research, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline 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class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34685309" href="https://independent.academia.edu/GrahamBurton1">Graham Burton</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Molecular human reproduction, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development","attachmentId":44324838,"attachmentType":"pdf","work_url":"https://www.academia.edu/23939008/Energy_status_and_HIF_signalling_in_chorionic_villi_show_no_evidence_of_hypoxic_stress_during_human_early_placental_development","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free 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class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="46880650" href="https://independent.academia.edu/GELOENAlain">GELOEN Alain</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Physiology, 2000</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Prenatal hypoxia impairs the postnatal development of neural and functional chemoafferent pathway in rat","attachmentId":71536142,"attachmentType":"pdf","work_url":"https://www.academia.edu/55872588/Prenatal_hypoxia_impairs_the_postnatal_development_of_neural_and_functional_chemoafferent_pathway_in_rat","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline 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class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="72740074" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72740074/Hyperoxia_disrupts_vascular_endothelial_growth_factor_nitric_oxide_signaling_and_decreases_growth_of_endothelial_colony_forming_cells_from_preterm_infants">Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20169789" href="https://wisc.academia.edu/VivekBalasubramaniam">Vivek Balasubramaniam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">AJP: Lung Cellular and Molecular Physiology, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link 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