CINXE.COM

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Back to Pathways </div> </div> <div class="pw_menu_block"> <div class="et-pathways-topics pathway_menu_items"> <div class="pathways-block"> <h5 class="pathways-title"> <a href="/pathways">Interactive Pathways & Processes</a></h5> <ul class="pathways-ul" data-count="10" id="menuPathways"> <li class="pathways-li "> <form id="pathways_cancer_pathways" action="/pathways/cancer" method="post"> <a href="/pathways/cancer" data-form="pathways_cancer_pathways" class="pathway_link"> <span class="icon-"> Cancer Pathways </span> </a> <input type="hidden" name="pw_parent" value="Cancer"> </form> </li> <li class="pathways-li "> <form id="pathways_cardiovascular_biology_pathways" action="/pathways/cardiovascular-biology" method="post"> <a href="/pathways/cardiovascular-biology" data-form="pathways_cardiovascular_biology_pathways" class="pathway_link"> <span class="icon-"> Cardiovascular Biology Pathways </span> </a> <input type="hidden" name="pw_parent" value="cardiovascular"> </form> </li> <li 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</div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>T Cell Co-Signaling Pathway: Ligand-Receptor Interactions</h1> <p id="pw-intro-txt">Click on one of the subfamilies of IgSF or TNFRSF co-signaling receptors shown in the Explore Pathways box below to see how the different members of each family affect T cell activation.<br></p> <div id="pw-con" data-mapname="" data-primary_segment="tcellco-signaling_all"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"> <li class="pw-drk-blu-btn" style="text-decoration:none; cursor:default;"><strong>IgSF</strong>:</li> <li data-segment="TCellCo-Signaling_B7-CD28" data-background_image="tcellcosignaling_b7-cd28_bkgrd.png?t=2" data-pathway_segment="TCellCo-Signaling_B7-CD28showPathwayTable202" class="pw_rdblue_sm pw_sm_btn"><a ><span>B7/CD28</span></li> <li data-segment="TCellCo-Signaling_Butyrophilins" data-background_image="tcellcosignaling_butyrophilins_bkgrd.png?t=3" data-pathway_segment="TCellCo-Signaling_ButyrophilinsshowPathwayTable203" class="pw_rdblue_sm pw_sm_btn"><a href="#slam2" ><span>Butyrophilins</span></li> <li data-segment="TCellCo-Signaling_SLAM" data-background_image="tcellcosignaling_slam_bkgrd.png?t=3" data-pathway_segment="TCellCo-Signaling_SLAMshowPathwayTable204" class="pw_rdblue_sm pw_sm_btn"><a href="#slam2" ><span>CD2/SLAM</span></li> <li data-segment="TCellCo-Signaling_TIM" data-background_image="tcellcosignaling_tim_bkgrd.png?t=3" data-pathway_segment="TCellCo-Signaling_TIMshowPathwayTable205" class="pw_rdblue_sm pw_sm_btn"><a href="#slam2" ><span>TIM</span></li> <li data-segment="TCellCo-Signaling_Nectin" data-background_image="tcellcosignaling_nectin_bkgrd.png?t=3" data-pathway_segment="TCellCo-Signaling_NectinshowPathwayTable206" class="pw_rdblue_sm pw_sm_btn"><a href="#slam2" ><span>Nectin and Nectin-like Binding Proteins</span></li> <li data-segment="TCellCo-Signaling_Other" data-background_image="tcellcosignaling_other_bkgrd.png?t=3" data-pathway_segment="TCellCo-Signaling_OthershowPathwayTable207" class="pw_rdblue_sm pw_sm_btn"><a href="#slam2" ><span>Other</span></li> <li class="pw-drk-blu-btn" style="text-decoration:none; cursor:default;"><strong>TNFRSF</strong>:</li> <li data-segment="TCellCo-Signaling_TNFRSFTypeL" data-background_image="tcellcosignaling_typel_bkgrd.png?t=4" data-pathway_segment="TCellCo-Signaling_TNFRSFTypeLshowPathwayTable209" class="pw_rdblue_sm pw_sm_btn"><a href="#type" ><span>Type L</span></li> <li data-segment="TCellCo-Signaling_TNFRSFTypeV" data-background_image="tcellcosignaling_typev_bkgrd.png?t=4" data-pathway_segment="TCellCo-Signaling_TNFRSFTypeVshowPathwayTable210" class="pw_rdblue_sm pw_sm_btn"><a href="#typev" ><span>Type V</span></li> <li data-segment="TCellCo-Signaling_all" data-background_image="tcellcosignaling_bkgrd.png?t=5" data-pathway_segment="TCellCo-Signaling_all" class="pw_sm_btn-active"><span>View All</span></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> T Cell Co-Signaling Pathway: Ligand-Receptor Interactions </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray1 pw-gray" style="top:34.66668701171875px;left:210px;"> APC </div> <div id="el1_off" data-id="1" data-set="APC" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off1" style="top:34.66668701171875px;left:210px;"> APC</div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el2_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray2 pw-gray" style="top:54px;left:330px;"> Signal 1 </div> <div id="el2_off" data-id="2" data-set="Signal1" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off2" style="top:54px;left:330px;"> Signal 1</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el3_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray3 pw-gray" style="top:57.333343505859375px;left:456.00006103515625px;"> T Cell </div> <div id="el3_off" data-id="3" data-set="TCell" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off3" style="top:57.333343505859375px;left:456.00006103515625px;"> T Cell</div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el4_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-sprite el-gray4 pw-gray" style="top:60px;left:314px;"> </div> <div id="el4_off" data-id="4" data-set="MHCII4" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-sprite el-off4" style="top:60px;left:314px;"> </div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=MHC class II (I-A/I-E)">MHC class II (I-A/I-E)</a><br><a href="https://www.rndsystems.com/search?common_name=HLA-DR">HLA-DR</a><br> </div> </div> <div id="el5_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray5 pw-gray" style="top:37px;left:288px;"> MHC II </div> <div id="el5_off" data-id="5" data-set="MHCII4" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off5" style="top:37px;left:288px;"> MHC II</div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=MHC class II (I-A/I-E)">MHC class II (I-A/I-E)</a><br><a href="https://www.rndsystems.com/search?common_name=HLA-DR">HLA-DR</a><br> </div> </div> <div id="el6_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-sprite el-gray6 pw-gray" style="top:64.66667175292969px;left:338px;"> </div> <div id="el6_off" data-id="6" data-set="TCR-CD3Complex5" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-sprite el-off6" style="top:64.66667175292969px;left:338px;"> </div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD3">CD3</a><br><a href="https://www.rndsystems.com/search?common_name=CD3 epsilon">CD3 epsilon</a><br> </div> </div> <div id="el7_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray7 pw-gray" style="top:80.66667175292969px;left:392.00006103515625px;"> TCR-CD3 Complex </div> <div id="el7_off" data-id="7" data-set="TCR-CD3Complex5" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off7" style="top:80.66667175292969px;left:392.00006103515625px;"> TCR-CD3 Complex</div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD3">CD3</a><br><a href="https://www.rndsystems.com/search?common_name=CD3 epsilon">CD3 epsilon</a><br> </div> </div> <div id="el8_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray8 pw-gray" style="top:118px;left:322px;"> Signal 2 </div> <div id="el8_off" data-id="8" data-set="Signal2" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off8" style="top:118px;left:322px;"> Signal 2</div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el9_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-gray9 pw-gray" style="top:179.33333587646484px;left:136px;"> Co-stimulatory </div> <div id="el9_off" data-id="9" data-set="Co-stimulatory" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-off9" style="top:179.33333587646484px;left:136px;"> Co-stimulatory</div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el10_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-gray10 pw-gray" style="top:194px;left:6px;"> Ig Superfamily </div> <div id="el10_off" data-id="10" data-set="IgSuperfamily" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-off10" style="top:194px;left:6px;"> Ig Superfamily</div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el11_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray11 pw-gray" style="top:-450px;left:-450px;"> APC </div> <div id="el11_off" data-id="11" data-set="APC" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off11" style="top:-450px;left:-450px;"> APC</div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el12_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray12 pw-gray" style="top:-937.3333435058594px;left:-406px;"> T Cell </div> <div id="el12_off" data-id="12" data-set="TCell" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off12" style="top:-937.3333435058594px;left:-406px;"> T Cell</div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el13_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-gray13 pw-gray" style="top:180px;left:562.0000610351562px;"> Co-inhibitory </div> <div id="el13_off" data-id="13" data-set="Co-inhibitory" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-off13" style="top:180px;left:562.0000610351562px;"> Co-inhibitory</div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el14_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray14 pw-gray" style="top:-913.6666870117188px;left:-404px;"> APC </div> <div id="el14_off" data-id="14" data-set="APC" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off14" style="top:-913.6666870117188px;left:-404px;"> APC</div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el15_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray15 pw-gray" style="top:-450px;left:-450px;"> T Cell </div> <div id="el15_off" data-id="15" data-set="TCell" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off15" style="top:-450px;left:-450px;"> T Cell</div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el16_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray16 pw-gray" style="top:-1050.0000610351562px;left:-420px;"> B7-CD28 Families </div> <div id="el16_off" data-id="16" data-set="B7-CD28Families" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off16" style="top:-1050.0000610351562px;left:-420px;"> B7-CD28 Families</div> <div id="el16_ct" class="pw-tooltip" data-id="16"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el17_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray17 pw-gray" style="top:244.00001525878906px;left:104px;"> </div> <div id="el17_off" data-id="17" data-set="B7-1CD8015" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off17" style="top:244.00001525878906px;left:104px;"> </div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-1/CD80">B7-1</a><br> </div> </div> <div id="el18_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray18 pw-gray" style="top:244.33334350585938px;left:38px;"> B7-1/CD80 </div> <div id="el18_off" data-id="18" data-set="B7-1CD8015" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off18" style="top:244.33334350585938px;left:38px;"> B7-1/CD80</div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-1/CD80">B7-1</a><br> </div> </div> <div id="el19_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray19 pw-gray" style="top:282.00001525878906px;left:102px;"> </div> <div id="el19_off" data-id="19" data-set="B7-2CD8616" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off19" style="top:282.00001525878906px;left:102px;"> </div> <div id="el19_ct" class="pw-tooltip" data-id="19"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-2/CD86">B7-2</a><br> </div> </div> <div id="el20_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray20 pw-gray" style="top:283.6666793823242px;left:36px;"> B7-2/CD86 </div> <div id="el20_off" data-id="20" data-set="B7-2CD8616" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off20" style="top:283.6666793823242px;left:36px;"> B7-2/CD86</div> <div id="el20_ct" class="pw-tooltip" data-id="20"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-2/CD86">B7-2</a><br> </div> </div> <div id="el21_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray21 pw-gray" style="top:320.3333435058594px;left:104px;"> </div> <div id="el21_off" data-id="21" data-set="B7-H2ICOSL17" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off21" style="top:320.3333435058594px;left:104px;"> </div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H2">B7-H2</a><br> </div> </div> <div id="el22_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray22 pw-gray" style="top:321.66667652130127px;left:22.66668701171875px;"> B7-H2/ICOS L </div> <div id="el22_off" data-id="22" data-set="B7-H2ICOSL17" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off22" style="top:321.66667652130127px;left:22.66668701171875px;"> B7-H2/ICOS L</div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H2">B7-H2</a><br> </div> </div> <div id="el23_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray23 pw-gray" style="top:363.3333330154419px;left:104.66668701171875px;"> </div> <div id="el23_off" data-id="23" data-set="B7-H1PD-L118" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off23" style="top:363.3333330154419px;left:104.66668701171875px;"> </div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L1/B7-H1">B7-H1</a><br> </div> </div> <div id="el24_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray24 pw-gray" style="top:364.3333330154419px;left:24.66668701171875px;"> B7-H1/PD-L1 </div> <div id="el24_off" data-id="24" data-set="B7-H1PD-L118" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off24" style="top:364.3333330154419px;left:24.66668701171875px;"> B7-H1/PD-L1</div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L1/B7-H1">B7-H1</a><br> </div> </div> <div id="el25_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray25 pw-gray" style="top:406.00002002716064px;left:104.66668701171875px;"> </div> <div id="el25_off" data-id="25" data-set="twoIgB7-H3-Mouse-19" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off25" style="top:406.00002002716064px;left:104.66668701171875px;"> </div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el26_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray26 pw-gray" style="top:398.00002002716064px;left:44.66668701171875px;"> 2Ig B7-H3<br>(Mouse) </div> <div id="el26_off" data-id="26" data-set="twoIgB7-H3-Mouse-19" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off26" style="top:398.00002002716064px;left:44.66668701171875px;"> 2Ig B7-H3<br>(Mouse)</div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el27_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray27 pw-gray" style="top:445.66667652130127px;left:106.66668701171875px;"> </div> <div id="el27_off" data-id="27" data-set="fourIgB7-H3-Human-20" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off27" style="top:445.66667652130127px;left:106.66668701171875px;"> </div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el28_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray28 pw-gray" style="top:438.66667652130127px;left:46.66668701171875px;"> 4Ig B7-H3<br>(Human) </div> <div id="el28_off" data-id="28" data-set="fourIgB7-H3-Human-20" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off28" style="top:438.66667652130127px;left:46.66668701171875px;"> 4Ig B7-H3<br>(Human)</div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el29_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray29 pw-gray" style="top:483.00002002716064px;left:98.66668701171875px;"> </div> <div id="el29_off" data-id="29" data-set="B7-H7-Human-21" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off29" style="top:483.00002002716064px;left:98.66668701171875px;"> </div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H7/HHLA2">B7-H7</a><br> </div> </div> <div id="el30_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray30 pw-gray" style="top:478.3333330154419px;left:52px;"> B7-H7<br>(Human) </div> <div id="el30_off" data-id="30" data-set="B7-H7-Human-21" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off30" style="top:478.3333330154419px;left:52px;"> B7-H7<br>(Human)</div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H7/HHLA2">B7-H7</a><br> </div> </div> <div id="el31_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray31 pw-gray" style="top:261.66667652130127px;left:204.66668701171875px;"> </div> <div id="el31_off" data-id="31" data-set="CD2822" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off31" style="top:261.66667652130127px;left:204.66668701171875px;"> </div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD28">CD28</a><br> </div> </div> <div id="el32_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray32 pw-gray" style="top:267.00002002716064px;left:244.66668701171875px;"> CD28 </div> <div id="el32_off" data-id="32" data-set="CD2822" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off32" style="top:267.00002002716064px;left:244.66668701171875px;"> CD28</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD28">CD28</a><br> </div> </div> <div id="el33_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray33 pw-gray" style="top:316.3333330154419px;left:202.66668701171875px;"> </div> <div id="el33_off" data-id="33" data-set="ICOS23" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off33" style="top:316.3333330154419px;left:202.66668701171875px;"> </div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=ICOS">ICOS</a><br> </div> </div> <div id="el34_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray34 pw-gray" style="top:320.66667652130127px;left:244.66668701171875px;"> ICOS </div> <div id="el34_off" data-id="34" data-set="ICOS23" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off34" style="top:320.66667652130127px;left:244.66668701171875px;"> ICOS</div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=ICOS">ICOS</a><br> </div> </div> <div id="el35_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-gray35 pw-gray" style="top:380px;left:258.66668701171875px;"> Unknown<br>Receptors </div> <div id="el35_off" data-id="35" data-set="UnknownReceptors3" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-off35" style="top:380px;left:258.66668701171875px;"> Unknown<br>Receptors </div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el36_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray36 pw-gray" style="top:479.6666793823242px;left:202.66668701171875px;"> </div> <div id="el36_off" data-id="36" data-set="CD28H25" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off36" style="top:479.6666793823242px;left:202.66668701171875px;"> </div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TMIGD2/CD28H">CD28H</a><br> </div> </div> <div id="el37_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray37 pw-gray" style="top:484.6666793823242px;left:244.66668701171875px;"> CD28H </div> <div id="el37_off" data-id="37" data-set="CD28H25" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off37" style="top:484.6666793823242px;left:244.66668701171875px;"> CD28H</div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TMIGD2/CD28H">CD28H</a><br> </div> </div> <div id="el38_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray38 pw-gray" style="top:237.67708587646484px;left:516.666748046875px;"> </div> <div id="el38_off" data-id="38" data-set="B7-1CD8026" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off38" style="top:237.67708587646484px;left:516.666748046875px;"> </div> <div id="el38_ct" class="pw-tooltip" data-id="38"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-1/CD80">B7-1</a><br> </div> </div> <div id="el39_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray39 pw-gray" style="top:237.33333587646484px;left:450.666748046875px;"> B7-1/CD80 </div> <div id="el39_off" data-id="39" data-set="B7-1CD8026" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off39" style="top:237.33333587646484px;left:450.666748046875px;"> B7-1/CD80</div> <div id="el39_ct" class="pw-tooltip" data-id="39"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-1/CD80">B7-1</a><br> </div> </div> <div id="el40_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray40 pw-gray" style="top:264.0000114440918px;left:516.666748046875px;"> </div> <div id="el40_off" data-id="40" data-set="B7-2CD8627" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off40" style="top:264.0000114440918px;left:516.666748046875px;"> </div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-2/CD86">B7-2</a><br> </div> </div> <div id="el41_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray41 pw-gray" style="top:263.00000762939453px;left:450.666748046875px;"> B7-2/CD86 </div> <div id="el41_off" data-id="41" data-set="B7-2CD8627" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off41" style="top:263.00000762939453px;left:450.666748046875px;"> B7-2/CD86</div> <div id="el41_ct" class="pw-tooltip" data-id="41"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-2/CD86">B7-2</a><br> </div> </div> <div id="el42_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray42 pw-gray" style="top:285.6666793823242px;left:518.666748046875px;"> </div> <div id="el42_off" data-id="42" data-set="B7-H1PD-L128" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off42" style="top:285.6666793823242px;left:518.666748046875px;"> </div> <div id="el42_ct" class="pw-tooltip" data-id="42"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L1/B7-H1">B7-H1</a><br> </div> </div> <div id="el43_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray43 pw-gray" style="top:286.6666793823242px;left:436.666748046875px;"> B7-H1/PD-L1 </div> <div id="el43_off" data-id="43" data-set="B7-H1PD-L128" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off43" style="top:286.6666793823242px;left:436.666748046875px;"> B7-H1/PD-L1</div> <div id="el43_ct" class="pw-tooltip" data-id="43"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L1/B7-H1">B7-H1</a><br> </div> </div> <div id="el44_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray44 pw-gray" style="top:310.3333435058594px;left:518.666748046875px;"> </div> <div id="el44_off" data-id="44" data-set="PD-L2B7-DC29" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off44" style="top:310.3333435058594px;left:518.666748046875px;"> </div> <div id="el44_ct" class="pw-tooltip" data-id="44"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L2/B7-DC">PD-L2</a><br> </div> </div> <div id="el45_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray45 pw-gray" style="top:308.3333435058594px;left:434.666748046875px;"> PD-L2/B7-DC </div> <div id="el45_off" data-id="45" data-set="PD-L2B7-DC29" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off45" style="top:308.3333435058594px;left:434.666748046875px;"> PD-L2/B7-DC</div> <div id="el45_ct" class="pw-tooltip" data-id="45"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L2/B7-DC">PD-L2</a><br> </div> </div> <div id="el46_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray46 pw-gray" style="top:333.0000114440918px;left:520.666748046875px;"> </div> <div id="el46_off" data-id="46" data-set="twoIgB7-H3-Mouse-30" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off46" style="top:333.0000114440918px;left:520.666748046875px;"> </div> <div id="el46_ct" class="pw-tooltip" data-id="46"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el47_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray47 pw-gray" style="top:330.6666793823242px;left:460.666748046875px;"> 2Ig B7-H3<br>(Mouse) </div> <div id="el47_off" data-id="47" data-set="twoIgB7-H3-Mouse-30" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off47" style="top:330.6666793823242px;left:460.666748046875px;"> 2Ig B7-H3<br>(Mouse)</div> <div id="el47_ct" class="pw-tooltip" data-id="47"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el48_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray48 pw-gray" style="top:370.3333339691162px;left:518.666748046875px;"> </div> <div id="el48_off" data-id="48" data-set="fourIgB7-H3-Human-31" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off48" style="top:370.3333339691162px;left:518.666748046875px;"> </div> <div id="el48_ct" class="pw-tooltip" data-id="48"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el49_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray49 pw-gray" style="top:365.3333339691162px;left:462.666748046875px;"> 4Ig B7-H3<br>(Human) </div> <div id="el49_off" data-id="49" data-set="fourIgB7-H3-Human-31" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off49" style="top:365.3333339691162px;left:462.666748046875px;"> 4Ig B7-H3<br>(Human)</div> <div id="el49_ct" class="pw-tooltip" data-id="49"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H3">B7-H3</a><br> </div> </div> <div id="el50_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray50 pw-gray" style="top:408.00002098083496px;left:522.666748046875px;"> </div> <div id="el50_off" data-id="50" data-set="B7-H432" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off50" style="top:408.00002098083496px;left:522.666748046875px;"> </div> <div id="el50_ct" class="pw-tooltip" data-id="50"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H4">B7-H4</a><br> </div> </div> <div id="el51_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray51 pw-gray" style="top:408.00002098083496px;left:478.666748046875px;"> B7-H4 </div> <div id="el51_off" data-id="51" data-set="B7-H432" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off51" style="top:408.00002098083496px;left:478.666748046875px;"> B7-H4</div> <div id="el51_ct" class="pw-tooltip" data-id="51"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H4">B7-H4</a><br> </div> </div> <div id="el52_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray52 pw-gray" style="top:435.00002098083496px;left:518.666748046875px;"> </div> <div id="el52_off" data-id="52" data-set="B7-H5VISTA33" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off52" style="top:435.00002098083496px;left:518.666748046875px;"> </div> <div id="el52_ct" class="pw-tooltip" data-id="52"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=VISTA/B7-H5/PD-1H">VISTA</a><br> </div> </div> <div id="el53_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray53 pw-gray" style="top:431.6666774749756px;left:442.666748046875px;"> B7-H5/VISTA </div> <div id="el53_off" data-id="53" data-set="B7-H5VISTA33" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off53" style="top:431.6666774749756px;left:442.666748046875px;"> B7-H5/VISTA</div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=VISTA/B7-H5/PD-1H">VISTA</a><br> </div> </div> <div id="el54_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-gray54 pw-gray" style="top:454.00002098083496px;left:468.666748046875px;"> Unknown<br>Ligand </div> <div id="el54_off" data-id="54" data-set="UnknownLigand" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-off54" style="top:454.00002098083496px;left:468.666748046875px;"> Unknown<br>Ligand</div> <div id="el54_ct" class="pw-tooltip" data-id="54"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el55_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray55 pw-gray" style="top:485.3333339691162px;left:514.666748046875px;"> </div> <div id="el55_off" data-id="55" data-set="B7-H735" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off55" style="top:485.3333339691162px;left:514.666748046875px;"> </div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H7/HHLA2">B7-H7</a><br> </div> </div> <div id="el56_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray56 pw-gray" style="top:489.6666774749756px;left:476.666748046875px;"> B7-H7 </div> <div id="el56_off" data-id="56" data-set="B7-H735" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off56" style="top:489.6666774749756px;left:476.666748046875px;"> B7-H7 </div> <div id="el56_ct" class="pw-tooltip" data-id="56"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-H7/HHLA2">B7-H7</a><br> </div> </div> <div id="el57_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray57 pw-gray" style="top:508.00002098083496px;left:502.666748046875px;"> </div> <div id="el57_off" data-id="57" data-set="HVEM36" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off57" style="top:508.00002098083496px;left:502.666748046875px;"> </div> <div id="el57_ct" class="pw-tooltip" data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=HVEM/TNFRSF14">HVEM</a><br> </div> </div> <div id="el58_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray58 pw-gray" style="top:514.3333339691162px;left:468.666748046875px;"> HVEM </div> <div id="el58_off" data-id="58" data-set="HVEM36" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off58" style="top:514.3333339691162px;left:468.666748046875px;"> HVEM</div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=HVEM/TNFRSF14">HVEM</a><br> </div> </div> <div id="el59_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray59 pw-gray" style="top:235.0000057220459px;left:624.6666870117188px;"> </div> <div id="el59_off" data-id="59" data-set="B7-H1PD-L137" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off59" style="top:235.0000057220459px;left:624.6666870117188px;"> </div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L1/B7-H1">B7-H1</a><br> </div> </div> <div id="el60_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray60 pw-gray" style="top:238.00000762939453px;left:664.6666870117188px;"> B7-H1/PD-L1 </div> <div id="el60_off" data-id="60" data-set="B7-H1PD-L137" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off60" style="top:238.00000762939453px;left:664.6666870117188px;"> B7-H1/PD-L1</div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-L1/B7-H1">B7-H1</a><br> </div> </div> <div id="el61_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray61 pw-gray" style="top:255.33333587646484px;left:621.6666870117188px;"> </div> <div id="el61_off" data-id="61" data-set="CTLA-438" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off61" style="top:255.33333587646484px;left:621.6666870117188px;"> </div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CTLA-4">CTLA-4</a><br> </div> </div> <div id="el62_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray62 pw-gray" style="top:258.6666793823242px;left:663.6666870117188px;"> CTLA-4 </div> <div id="el62_off" data-id="62" data-set="CTLA-438" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off62" style="top:258.6666793823242px;left:663.6666870117188px;"> CTLA-4</div> <div id="el62_ct" class="pw-tooltip" data-id="62"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CTLA-4">CTLA-4</a><br> </div> </div> <div id="el63_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray63 pw-gray" style="top:280.66668701171875px;left:620.6666870117188px;"> </div> <div id="el63_off" data-id="63" data-set="B7-1CD8039" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off63" style="top:280.66668701171875px;left:620.6666870117188px;"> </div> <div id="el63_ct" class="pw-tooltip" data-id="63"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-1/CD80">B7-1</a><br> </div> </div> <div id="el64_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray64 pw-gray" style="top:282.3333435058594px;left:662.6666870117188px;"> B7-1/CD80 </div> <div id="el64_off" data-id="64" data-set="B7-1CD8039" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off64" style="top:282.3333435058594px;left:662.6666870117188px;"> B7-1/CD80</div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=B7-1/CD80">B7-1</a><br> </div> </div> <div id="el65_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray65 pw-gray" style="top:308.6666793823242px;left:625.6666870117188px;"> </div> <div id="el65_off" data-id="65" data-set="PD-140" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off65" style="top:308.6666793823242px;left:625.6666870117188px;"> </div> <div id="el65_ct" class="pw-tooltip" data-id="65"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-1">PD-1</a><br> </div> </div> <div id="el66_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray66 pw-gray" style="top:311.0000114440918px;left:663.6666870117188px;"> PD-1 </div> <div id="el66_off" data-id="66" data-set="PD-140" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off66" style="top:311.0000114440918px;left:663.6666870117188px;"> PD-1</div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=PD-1">PD-1</a><br> </div> </div> <div id="el67_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-gray67 pw-gray" style="top:389.3333435058594px;left:690.6666870117188px;"> Unknown Receptors </div> <div id="el67_off" data-id="67" data-set="UnknownReceptors4" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-off67" style="top:389.3333435058594px;left:690.6666870117188px;"> Unknown Receptors</div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el68_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray68 pw-gray" style="top:438.0000114440918px;left:619.6666870117188px;"> </div> <div id="el68_off" data-id="68" data-set="B7-H5VISTA42" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off68" style="top:438.0000114440918px;left:619.6666870117188px;"> </div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=VISTA/B7-H5/PD-1H">VISTA</a><br> </div> </div> <div id="el69_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray69 pw-gray" style="top:439.0000114440918px;left:664.6666870117188px;"> B7-H5/VISTA </div> <div id="el69_off" data-id="69" data-set="B7-H5VISTA42" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off69" style="top:439.0000114440918px;left:664.6666870117188px;"> B7-H5/VISTA</div> <div id="el69_ct" class="pw-tooltip" data-id="69"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=VISTA/B7-H5/PD-1H">VISTA</a><br> </div> </div> <div id="el70_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-gray70 pw-gray" style="top:464.3333435058594px;left:665.6666870117188px;"> Unknown Receptor </div> <div id="el70_off" data-id="70" data-set="UnknownReceptor" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label2 el-off70" style="top:464.3333435058594px;left:665.6666870117188px;"> Unknown Receptor</div> <div id="el70_ct" class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el71_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray71 pw-gray" style="top:497.3333435058594px;left:614.6666870117188px;"> </div> <div id="el71_off" data-id="71" data-set="BTLA44" data-type="" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off71" style="top:497.3333435058594px;left:614.6666870117188px;"> </div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTLA">BTLA</a><br> </div> </div> <div id="el72_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray72 pw-gray" style="top:501.6666793823242px;left:666.6666870117188px;"> BTLA </div> <div id="el72_off" data-id="72" data-set="BTLA44" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off72" style="top:501.6666793823242px;left:666.6666870117188px;"> BTLA</div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTLA">BTLA</a><br> </div> </div> <div id="el73_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-gray73 pw-gray" style="top:516.6666870117188px;left:607.3333129882812px;"> </div> <div id="el73_off" data-id="73" data-set="CD16045" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-sprite el-off73" style="top:516.6666870117188px;left:607.3333129882812px;"> </div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD160">CD160</a><br> </div> </div> <div id="el74_gry" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-gray74 pw-gray" style="top:521.0000305175781px;left:659.3333129882812px;"> CD160 </div> <div id="el74_off" data-id="74" data-set="CD16045" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_b7-cd28 pw-label el-off74" style="top:521.0000305175781px;left:659.3333129882812px;"> CD160</div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD160">CD160</a><br> </div> </div> <div id="el75_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label2 el-gray75 pw-gray" style="top:543.6666793823242px;left:134.33331298828125px;"> Co-stimulatory </div> <div id="el75_off" data-id="75" data-set="Co-stimulatory2" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label2 el-off75" style="top:543.6666793823242px;left:134.33331298828125px;"> Co-stimulatory</div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el76_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label2 el-gray76 pw-gray" style="top:560.0000228881836px;left:5.33331298828125px;"> Ig Superfamily </div> <div id="el76_off" data-id="76" data-set="IgSuperfamily2" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label2 el-off76" style="top:560.0000228881836px;left:5.33331298828125px;"> Ig Superfamily</div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el77_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-gray77 pw-gray" style="top:-450px;left:-450px;"> APC </div> <div id="el77_off" data-id="77" data-set="APC" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-off77" style="top:-450px;left:-450px;"> APC</div> <div id="el77_ct" class="pw-tooltip" data-id="77"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el78_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-gray78 pw-gray" style="top:-450px;left:-450px;"> T Cell </div> <div id="el78_off" data-id="78" data-set="TCell" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-off78" style="top:-450px;left:-450px;"> T Cell</div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el79_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label2 el-gray79 pw-gray" style="top:545.0000305175781px;left:557.3333129882812px;"> Co-inhibitory </div> <div id="el79_off" data-id="79" data-set="Co-inhibitory" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label2 el-off79" style="top:545.0000305175781px;left:557.3333129882812px;"> Co-inhibitory</div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el80_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-gray80 pw-gray" style="top:-491.33333587646484px;left:-472.6667022705078px;"> APC </div> <div id="el80_off" data-id="80" data-set="APC" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-off80" style="top:-491.33333587646484px;left:-472.6667022705078px;"> APC</div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el81_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-gray81 pw-gray" style="top:-571.6666870117188px;left:-425.6667022705078px;"> T Cell </div> <div id="el81_off" data-id="81" data-set="TCell" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins tcellco-signaling_slam tcellco-signaling_tim tcellco-signaling_nectin tcellco-signaling_other pw-label el-off81" style="top:-571.6666870117188px;left:-425.6667022705078px;"> T Cell</div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el82_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray82 pw-gray" style="top:-615.0000152587891px;left:-423.6667022705078px;"> Butyrophilins </div> <div id="el82_off" data-id="82" data-set="Butyrophilins" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off82" style="top:-615.0000152587891px;left:-423.6667022705078px;"> Butyrophilins</div> <div id="el82_ct" class="pw-tooltip" data-id="82"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el83_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-gray83 pw-gray" style="top:655.3333435058594px;left:101.33331298828125px;"> </div> <div id="el83_off" data-id="83" data-set="BTNL8-Human-54" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-off83" style="top:655.3333435058594px;left:101.33331298828125px;"> </div> <div id="el83_ct" class="pw-tooltip" data-id="83"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTNL8">BTNL8</a><br> </div> </div> <div id="el84_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray84 pw-gray" style="top:649.3333435058594px;left:51px;"> BTNL8<br>(Human) </div> <div id="el84_off" data-id="84" data-set="BTNL8-Human-54" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off84" style="top:649.3333435058594px;left:51px;"> BTNL8<br>(Human)</div> <div id="el84_ct" class="pw-tooltip" data-id="84"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTNL8">BTNL8</a><br> </div> </div> <div id="el85_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-gray85 pw-gray" style="top:651.0000305175781px;left:243.33331298828125px;"> Unknown<br>Receptor </div> <div id="el85_off" data-id="85" data-set="UnknownReceptor4" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-off85" style="top:651.0000305175781px;left:243.33331298828125px;"> Unknown<br>Receptor</div> <div id="el85_ct" class="pw-tooltip" data-id="85"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el86_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-gray86 pw-gray" style="top:601.3333435058594px;left:518.3333129882812px;"> </div> <div id="el86_off" data-id="86" data-set="BTN1A156" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-off86" style="top:601.3333435058594px;left:518.3333129882812px;"> </div> <div id="el86_ct" class="pw-tooltip" data-id="86"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTN1A1/Butyrophilin">BTN1A1</a><br> </div> </div> <div id="el87_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray87 pw-gray" style="top:600.3333435058594px;left:468.33331298828125px;"> BTN1A1 </div> <div id="el87_off" data-id="87" data-set="BTN1A156" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off87" style="top:600.3333435058594px;left:468.33331298828125px;"> BTN1A1</div> <div id="el87_ct" class="pw-tooltip" data-id="87"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTN1A1/Butyrophilin">BTN1A1</a><br> </div> </div> <div id="el88_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-gray88 pw-gray" style="top:627.6666870117188px;left:521.3333129882812px;"> </div> <div id="el88_off" data-id="88" data-set="BTN2A257" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-off88" style="top:627.6666870117188px;left:521.3333129882812px;"> </div> <div id="el88_ct" class="pw-tooltip" data-id="88"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTN2A2/Butyrophilin 2A2">BTN2A2</a><br> </div> </div> <div id="el89_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray89 pw-gray" style="top:623.6666870117188px;left:467.33331298828125px;"> BTN2A2 </div> <div id="el89_off" data-id="89" data-set="BTN2A257" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off89" style="top:623.6666870117188px;left:467.33331298828125px;"> BTN2A2</div> <div id="el89_ct" class="pw-tooltip" data-id="89"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTN2A2/Butyrophilin 2A2">BTN2A2</a><br> </div> </div> <div id="el90_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-gray90 pw-gray" style="top:651.3333435058594px;left:426.33331298828125px;"> Unknown Ligand </div> <div id="el90_off" data-id="90" data-set="UnknownLigand2" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-off90" style="top:651.3333435058594px;left:426.33331298828125px;"> Unknown Ligand</div> <div id="el90_ct" class="pw-tooltip" data-id="90"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el91_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-gray91 pw-gray" style="top:673.6666870117188px;left:519.3333129882812px;"> </div> <div id="el91_off" data-id="91" data-set="BTN3A159" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-off91" style="top:673.6666870117188px;left:519.3333129882812px;"> </div> <div id="el91_ct" class="pw-tooltip" data-id="91"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD277/BTN3A1">BTN3A1</a><br><a href="https://www.rndsystems.com/search?common_name=BTN3A1/2">BTN3A1/2</a><br> </div> </div> <div id="el92_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray92 pw-gray" style="top:675.6666870117188px;left:471.33331298828125px;"> BTN3A1 </div> <div id="el92_off" data-id="92" data-set="BTN3A159" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off92" style="top:675.6666870117188px;left:471.33331298828125px;"> BTN3A1</div> <div id="el92_ct" class="pw-tooltip" data-id="92"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD277/BTN3A1">BTN3A1</a><br><a href="https://www.rndsystems.com/search?common_name=BTN3A1/2">BTN3A1/2</a><br> </div> </div> <div id="el93_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-gray93 pw-gray" style="top:696.0000305175781px;left:517.3333129882812px;"> </div> <div id="el93_off" data-id="93" data-set="BTNL1-Mouse-60" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-off93" style="top:696.0000305175781px;left:517.3333129882812px;"> </div> <div id="el93_ct" class="pw-tooltip" data-id="93"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/btnl1">BTNL1</a><br> </div> </div> <div id="el94_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray94 pw-gray" style="top:696.0000152587891px;left:426.33331298828125px;"> BTNL1 (Mouse) </div> <div id="el94_off" data-id="94" data-set="BTNL1-Mouse-60" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off94" style="top:696.0000152587891px;left:426.33331298828125px;"> BTNL1 (Mouse)</div> <div id="el94_ct" class="pw-tooltip" data-id="94"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/btnl1">BTNL1</a><br> </div> </div> <div id="el95_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-gray95 pw-gray" style="top:716.3333435058594px;left:525.0000610351562px;"> </div> <div id="el95_off" data-id="95" data-set="BTNL261" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-off95" style="top:716.3333435058594px;left:525.0000610351562px;"> </div> <div id="el95_ct" class="pw-tooltip" data-id="95"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTNL2/Butyrophilin-like 2">BTNL2</a><br> </div> </div> <div id="el96_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray96 pw-gray" style="top:718.0000305175781px;left:479px;"> BTNL2 </div> <div id="el96_off" data-id="96" data-set="BTNL261" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off96" style="top:718.0000305175781px;left:479px;"> BTNL2</div> <div id="el96_ct" class="pw-tooltip" data-id="96"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=BTNL2/Butyrophilin-like 2">BTNL2</a><br> </div> </div> <div id="el97_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-gray97 pw-gray" style="top:609.3333435058594px;left:675.0000610351562px;"> Unknown Receptors </div> <div id="el97_off" data-id="97" data-set="UnknownReceptors5" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-off97" style="top:609.3333435058594px;left:675.0000610351562px;"> Unknown Receptors</div> <div id="el97_ct" class="pw-tooltip" data-id="97"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el98_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-gray98 pw-gray" style="top:650.0000305175781px;left:616.0000610351562px;"> </div> <div id="el98_off" data-id="98" data-set="BTN3A163" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite el-off98" style="top:650.0000305175781px;left:616.0000610351562px;"> </div> <div id="el98_ct" class="pw-tooltip" data-id="98"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD277/BTN3A1">BTN3A1</a><br><a href="https://www.rndsystems.com/search?common_name=BTN3A1/2">BTN3A1/2</a><br> </div> </div> <div id="el99_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-gray99 pw-gray" style="top:652.0000305175781px;left:664.0000610351562px;"> BTN3A1 </div> <div id="el99_off" data-id="99" data-set="BTN3A163" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label el-off99" style="top:652.0000305175781px;left:664.0000610351562px;"> BTN3A1</div> <div id="el99_ct" class="pw-tooltip" data-id="99"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD277/BTN3A1">BTN3A1</a><br><a href="https://www.rndsystems.com/search?common_name=BTN3A1/2">BTN3A1/2</a><br> </div> </div> <div id="el100_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-gray100 pw-gray" style="top:687.3333435058594px;left:689.0000610351562px;"> Unknown Receptors </div> <div id="el100_off" data-id="100" data-set="UnknownReceptors6" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-label2 el-off100" style="top:687.3333435058594px;left:689.0000610351562px;"> Unknown Receptors</div> <div id="el100_ct" class="pw-tooltip" data-id="100"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el101_gry" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite pw-sprite-inactive el-gray101 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el101_off" data-id="101" data-set="UnknownReceptor" data-type="" class="tcellco-signaling_all tcellco-signaling_butyrophilins pw-sprite pw-sprite-inactive el-off101" style="top:-450px;left:-450px;"> </div> <div id="el101_ct" class="pw-tooltip" data-id="101"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el102_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-gray102 pw-gray" style="top:702.0000305175781px;left:112px;"> </div> <div id="el102_off" data-id="102" data-set="CD48SLAMF2-MouseandRat-66" data-type="" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-off102" style="top:702.0000305175781px;left:112px;"> </div> <div id="el102_ct" class="pw-tooltip" data-id="102"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD48/SLAMF2">CD48</a><br> </div> </div> <div id="el103_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-label pw-right el-gray103 pw-gray" style="top:701.3333435058594px;left:22px;"> CD48/SLAMF2<br>(Mouse <br>and Rat) </div> <div id="el103_off" data-id="103" data-set="CD48SLAMF2-MouseandRat-66" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-label pw-right el-off103" style="top:701.3333435058594px;left:22px;"> CD48/SLAMF2<br>(Mouse <br>and Rat)</div> <div id="el103_ct" class="pw-tooltip" data-id="103"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD48/SLAMF2">CD48</a><br> </div> </div> <div id="el104_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-gray104 pw-gray" style="top:761.3333435058594px;left:102px;"> </div> <div id="el104_off" data-id="104" data-set="CD58LFA-3-Human-67" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-off104" style="top:761.3333435058594px;left:102px;"> </div> <div id="el104_ct" class="pw-tooltip" data-id="104"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD58/LFA-3">CD58</a><br> </div> </div> <div id="el105_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-gray105 pw-gray" style="top:761.0000305175781px;left:36px;"> CD58/LFA-3<br>(Human) </div> <div id="el105_off" data-id="105" data-set="CD58LFA-3-Human-67" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-off105" style="top:761.0000305175781px;left:36px;"> CD58/LFA-3<br>(Human)</div> <div id="el105_ct" class="pw-tooltip" data-id="105"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD58/LFA-3">CD58</a><br> </div> </div> <div id="el106_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-gray106 pw-gray" style="top:794.6666870117188px;left:102px;"> </div> <div id="el106_off" data-id="106" data-set="SLAMCD15068" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-off106" style="top:794.6666870117188px;left:102px;"> </div> <div id="el106_ct" class="pw-tooltip" data-id="106"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=SLAM/CD150">SLAM</a><br> </div> </div> <div id="el107_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-gray107 pw-gray" style="top:800.6666870117188px;left:24px;"> SLAM/CD150 </div> <div id="el107_off" data-id="107" data-set="SLAMCD15068" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-off107" style="top:800.6666870117188px;left:24px;"> SLAM/CD150</div> <div id="el107_ct" class="pw-tooltip" data-id="107"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=SLAM/CD150">SLAM</a><br> </div> </div> <div id="el108_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-gray108 pw-gray" style="top:730.3333435058594px;left:198px;"> </div> <div id="el108_off" data-id="108" data-set="CD269" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-off108" style="top:730.3333435058594px;left:198px;"> </div> <div id="el108_ct" class="pw-tooltip" data-id="108"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD2">CD2</a><br> </div> </div> <div id="el109_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-gray109 pw-gray" style="top:733.3333435058594px;left:244px;"> CD2 </div> <div id="el109_off" data-id="109" data-set="CD269" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-off109" style="top:733.3333435058594px;left:244px;"> CD2</div> <div id="el109_ct" class="pw-tooltip" data-id="109"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD2">CD2</a><br> </div> </div> <div id="el110_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-gray110 pw-gray" style="top:769.6666870117188px;left:204px;"> </div> <div id="el110_off" data-id="110" data-set="SLAMCD15070" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-off110" style="top:769.6666870117188px;left:204px;"> </div> <div id="el110_ct" class="pw-tooltip" data-id="110"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=SLAM/CD150">SLAM</a><br> </div> </div> <div id="el111_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-gray111 pw-gray" style="top:765.0000305175781px;left:244px;"> SLAM/<br>CD150 </div> <div id="el111_off" data-id="111" data-set="SLAMCD15070" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-off111" style="top:765.0000305175781px;left:244px;"> SLAM/<br>CD150</div> <div id="el111_ct" class="pw-tooltip" data-id="111"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=SLAM/CD150">SLAM</a><br> </div> </div> <div id="el112_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-gray112 pw-gray" style="top:775.3333435058594px;left:530px;"> </div> <div id="el112_off" data-id="112" data-set="CD48SLAMF271" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-off112" style="top:775.3333435058594px;left:530px;"> </div> <div id="el112_ct" class="pw-tooltip" data-id="112"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD48/SLAMF2">CD48</a><br> </div> </div> <div id="el113_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-gray113 pw-gray" style="top:775.6666870117188px;left:438px;"> CD48/SLAMF2 </div> <div id="el113_off" data-id="113" data-set="CD48SLAMF271" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-off113" style="top:775.6666870117188px;left:438px;"> CD48/SLAMF2</div> <div id="el113_ct" class="pw-tooltip" data-id="113"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD48/SLAMF2">CD48</a><br> </div> </div> <div id="el114_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-gray114 pw-gray" style="top:775.6666870117188px;left:618px;"> </div> <div id="el114_off" data-id="114" data-set="twoB4CD244SLAMF472" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-sprite el-off114" style="top:775.6666870117188px;left:618px;"> </div> <div id="el114_ct" class="pw-tooltip" data-id="114"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=2B4/CD244/SLAMF4">2B4</a><br> </div> </div> <div id="el115_gry" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-gray115 pw-gray" style="top:770.3333435058594px;left:666px;"> 2B4/CD244/<br>SLAMF4 </div> <div id="el115_off" data-id="115" data-set="twoB4CD244SLAMF472" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_slam pw-label el-off115" style="top:770.3333435058594px;left:666px;"> 2B4/CD244/<br>SLAMF4</div> <div id="el115_ct" class="pw-tooltip" data-id="115"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=2B4/CD244/SLAMF4">2B4</a><br> </div> </div> <div id="el116_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-gray116 pw-gray" style="top:-450px;left:-450px;"> TIM Family </div> <div id="el116_off" data-id="116" data-set="TIMFamily" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-off116" style="top:-450px;left:-450px;"> TIM Family</div> <div id="el116_ct" class="pw-tooltip" data-id="116"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el117_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-gray117 pw-gray" style="top:832.3333740234375px;left:104px;"> </div> <div id="el117_off" data-id="117" data-set="TIM-474" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-off117" style="top:832.3333740234375px;left:104px;"> </div> <div id="el117_ct" class="pw-tooltip" data-id="117"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-4">TIM-4</a><br> </div> </div> <div id="el118_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-gray118 pw-gray" style="top:837.6667098999023px;left:66.66668701171875px;"> TIM-4 </div> <div id="el118_off" data-id="118" data-set="TIM-474" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-off118" style="top:837.6667098999023px;left:66.66668701171875px;"> TIM-4</div> <div id="el118_ct" class="pw-tooltip" data-id="118"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-4">TIM-4</a><br> </div> </div> <div id="el119_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-gray119 pw-gray" style="top:834.6667175292969px;left:196.66668701171875px;"> </div> <div id="el119_off" data-id="119" data-set="TIM-175" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-off119" style="top:834.6667175292969px;left:196.66668701171875px;"> </div> <div id="el119_ct" class="pw-tooltip" data-id="119"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-1/KIM-1/HAVCR">TIM-1</a><br> </div> </div> <div id="el120_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-gray120 pw-gray" style="top:839.3333740234375px;left:242.66668701171875px;"> TIM-1 </div> <div id="el120_off" data-id="120" data-set="TIM-175" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-off120" style="top:839.3333740234375px;left:242.66668701171875px;"> TIM-1</div> <div id="el120_ct" class="pw-tooltip" data-id="120"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-1/KIM-1/HAVCR">TIM-1</a><br> </div> </div> <div id="el121_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-gray121 pw-gray" style="top:822.0000457763672px;left:518.666748046875px;"> </div> <div id="el121_off" data-id="121" data-set="TIM-476" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-off121" style="top:822.0000457763672px;left:518.666748046875px;"> </div> <div id="el121_ct" class="pw-tooltip" data-id="121"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-4">TIM-4</a><br> </div> </div> <div id="el122_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-gray122 pw-gray" style="top:826.0000305175781px;left:484.666748046875px;"> TIM-4 </div> <div id="el122_off" data-id="122" data-set="TIM-476" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-off122" style="top:826.0000305175781px;left:484.666748046875px;"> TIM-4</div> <div id="el122_ct" class="pw-tooltip" data-id="122"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-4">TIM-4</a><br> </div> </div> <div id="el123_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-gray123 pw-gray" style="top:843.3333435058594px;left:522.666748046875px;"> </div> <div id="el123_off" data-id="123" data-set="Galectin-977" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-off123" style="top:843.3333435058594px;left:522.666748046875px;"> </div> <div id="el123_ct" class="pw-tooltip" data-id="123"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Galectin-9">Galectin-9</a><br> </div> </div> <div id="el124_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-gray124 pw-gray" style="top:843.6666870117188px;left:464.666748046875px;"> Galectin-9 </div> <div id="el124_off" data-id="124" data-set="Galectin-977" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-off124" style="top:843.6666870117188px;left:464.666748046875px;"> Galectin-9</div> <div id="el124_ct" class="pw-tooltip" data-id="124"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Galectin-9">Galectin-9</a><br> </div> </div> <div id="el125_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-label2 el-gray125 pw-gray" style="top:814.0000305175781px;left:664.6666870117188px;"> Unknown Receptor </div> <div id="el125_off" data-id="125" data-set="UnknownReceptor7" data-type="" class="tcellco-signaling_all tcellco-signaling_tim pw-label2 el-off125" style="top:814.0000305175781px;left:664.6666870117188px;"> Unknown Receptor </div> <div id="el125_ct" class="pw-tooltip" data-id="125"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el126_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-gray126 pw-gray" style="top:842.0000305175781px;left:616.6666870117188px;"> </div> <div id="el126_off" data-id="126" data-set="TIM-379" data-type="" class="tcellco-signaling_all tcellco-signaling_tim pw-sprite el-off126" style="top:842.0000305175781px;left:616.6666870117188px;"> </div> <div id="el126_ct" class="pw-tooltip" data-id="126"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-3">TIM-3</a><br> </div> </div> <div id="el127_gry" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-gray127 pw-gray" style="top:844.6666870117188px;left:660.6666870117188px;"> TIM-3 </div> <div id="el127_off" data-id="127" data-set="TIM-379" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tim pw-label el-off127" style="top:844.6666870117188px;left:660.6666870117188px;"> TIM-3</div> <div id="el127_ct" class="pw-tooltip" data-id="127"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIM-3">TIM-3</a><br> </div> </div> <div id="el128_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-gray128 pw-gray" style="top:-450px;left:-450px;"> Nectin and Nectin-like Binding Receptors </div> <div id="el128_off" data-id="128" data-set="NectinandNectin-likeBindingReceptors" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-off128" style="top:-450px;left:-450px;"> Nectin and Nectin-like Binding Receptors</div> <div id="el128_ct" class="pw-tooltip" data-id="128"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el129_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-gray129 pw-gray" style="top:876.0000457763672px;left:101.66668701171875px;"> </div> <div id="el129_off" data-id="129" data-set="Nectin-2CD11281" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-off129" style="top:876.0000457763672px;left:101.66668701171875px;"> </div> <div id="el129_ct" class="pw-tooltip" data-id="129"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Nectin-2/CD112">Nectin-2/CD112</a><br> </div> </div> <div id="el130_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label pw-right el-gray130 pw-gray" style="top:871px;left:46px;"> Nectin-2/<br>CD112 </div> <div id="el130_off" data-id="130" data-set="Nectin-2CD11281" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label pw-right el-off130" style="top:871px;left:46px;"> Nectin-2/<br>CD112</div> <div id="el130_ct" class="pw-tooltip" data-id="130"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Nectin-2/CD112">Nectin-2/CD112</a><br> </div> </div> <div id="el131_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-gray131 pw-gray" style="top:908.6666870117188px;left:102.66668701171875px;"> </div> <div id="el131_off" data-id="131" data-set="CD155PVR82" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-off131" style="top:908.6666870117188px;left:102.66668701171875px;"> </div> <div id="el131_ct" class="pw-tooltip" data-id="131"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD155/PVR">CD155/PVR</a><br> </div> </div> <div id="el132_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-gray132 pw-gray" style="top:909.3333435058594px;left:33.66668701171875px;"> CD155/PVR </div> <div id="el132_off" data-id="132" data-set="CD155PVR82" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-off132" style="top:909.3333435058594px;left:33.66668701171875px;"> CD155/PVR</div> <div id="el132_ct" class="pw-tooltip" data-id="132"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD155/PVR">CD155/PVR</a><br> </div> </div> <div id="el133_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-gray133 pw-gray" style="top:901.3333435058594px;left:209.66668701171875px;"> </div> <div id="el133_off" data-id="133" data-set="DNAM-1CD22683" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-off133" style="top:901.3333435058594px;left:209.66668701171875px;"> </div> <div id="el133_ct" class="pw-tooltip" data-id="133"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=DNAM-1/CD226">DNAM-1/</a><br> </div> </div> <div id="el134_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-gray134 pw-gray" style="top:900.0000305175781px;left:245px;"> DNAM-1/<br>CD226 </div> <div id="el134_off" data-id="134" data-set="DNAM-1CD22683" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-off134" style="top:900.0000305175781px;left:245px;"> DNAM-1/<br>CD226</div> <div id="el134_ct" class="pw-tooltip" data-id="134"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=DNAM-1/CD226">DNAM-1/</a><br> </div> </div> <div id="el135_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-gray135 pw-gray" style="top:881.0000305175781px;left:516.6666870117188px;"> </div> <div id="el135_off" data-id="135" data-set="Nectin-2CD11284" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-off135" style="top:881.0000305175781px;left:516.6666870117188px;"> </div> <div id="el135_ct" class="pw-tooltip" data-id="135"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Nectin-2/CD112">Nectin-2/CD112</a><br> </div> </div> <div id="el136_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-gray136 pw-gray" style="top:881.6666870117188px;left:427.66668701171875px;"> Nectin-2/CD112 </div> <div id="el136_off" data-id="136" data-set="Nectin-2CD11284" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-off136" style="top:881.6666870117188px;left:427.66668701171875px;"> Nectin-2/CD112</div> <div id="el136_ct" class="pw-tooltip" data-id="136"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Nectin-2/CD112">Nectin-2/CD112</a><br> </div> </div> <div id="el137_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-gray137 pw-gray" style="top:906.6666870117188px;left:520.6666870117188px;"> </div> <div id="el137_off" data-id="137" data-set="CD155PVR85" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-off137" style="top:906.6666870117188px;left:520.6666870117188px;"> </div> <div id="el137_ct" class="pw-tooltip" data-id="137"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD155/PVR">CD155/PVR</a><br> </div> </div> <div id="el138_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-gray138 pw-gray" style="top:907.3333435058594px;left:449.66668701171875px;"> CD155/PVR </div> <div id="el138_off" data-id="138" data-set="CD155PVR85" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-off138" style="top:907.3333435058594px;left:449.66668701171875px;"> CD155/PVR</div> <div id="el138_ct" class="pw-tooltip" data-id="138"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD155/PVR">CD155/PVR</a><br> </div> </div> <div id="el139_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-gray139 pw-gray" style="top:933.3333435058594px;left:519.6666870117188px;"> </div> <div id="el139_off" data-id="139" data-set="Nectin-3CD11386" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-off139" style="top:933.3333435058594px;left:519.6666870117188px;"> </div> <div id="el139_ct" class="pw-tooltip" data-id="139"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Nectin-3">Nectin-3</a><br> </div> </div> <div id="el140_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-gray140 pw-gray" style="top:935.0000305175781px;left:427.66668701171875px;"> Nectin-3/CD113 </div> <div id="el140_off" data-id="140" data-set="Nectin-3CD11386" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-off140" style="top:935.0000305175781px;left:427.66668701171875px;"> Nectin-3/CD113</div> <div id="el140_ct" class="pw-tooltip" data-id="140"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Nectin-3">Nectin-3</a><br> </div> </div> <div id="el141_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-gray141 pw-gray" style="top:903.6666870117188px;left:628.6666870117188px;"> </div> <div id="el141_off" data-id="141" data-set="TIGIT87" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-sprite el-off141" style="top:903.6666870117188px;left:628.6666870117188px;"> </div> <div id="el141_ct" class="pw-tooltip" data-id="141"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIGIT">TIGIT</a><br> </div> </div> <div id="el142_gry" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-gray142 pw-gray" style="top:908.6666870117188px;left:665.6666870117188px;"> TIGIT </div> <div id="el142_off" data-id="142" data-set="TIGIT87" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_nectin pw-label el-off142" style="top:908.6666870117188px;left:665.6666870117188px;"> TIGIT</div> <div id="el142_ct" class="pw-tooltip" data-id="142"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=TIGIT">TIGIT</a><br> </div> </div> <div id="el143_gry" class="tcellco-signaling_all tcellco-signaling_other pw-label el-gray143 pw-gray" style="top:-450px;left:-450px;"> Other </div> <div id="el143_off" data-id="143" data-set="Other" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_other pw-label el-off143" style="top:-450px;left:-450px;"> Other</div> <div id="el143_ct" class="pw-tooltip" data-id="143"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el144_gry" class="tcellco-signaling_all tcellco-signaling_other pw-sprite el-gray144 pw-gray" style="top:979.6667175292969px;left:523px;"> </div> <div id="el144_off" data-id="144" data-set="Collagen89" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_other pw-sprite el-off144" style="top:979.6667175292969px;left:523px;"> </div> <div id="el144_ct" class="pw-tooltip" data-id="144"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Collagen I">Collagen I</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen II">Collagen II</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen III alpha 1/COL3A1">Collagen III alpha 1</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen IV alpha 1">Collagen IV</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen XXIII alpha 1">Collagen XXIII alpha 1</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen XXV alpha 1">Collagen XXV alpha 1</a><br> </div> </div> <div id="el145_gry" class="tcellco-signaling_all tcellco-signaling_other pw-label el-gray145 pw-gray" style="top:983.0000457763672px;left:468px;"> Collagen </div> <div id="el145_off" data-id="145" data-set="Collagen89" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_other pw-label el-off145" style="top:983.0000457763672px;left:468px;"> Collagen</div> <div id="el145_ct" class="pw-tooltip" data-id="145"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=Collagen I">Collagen I</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen II">Collagen II</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen III alpha 1/COL3A1">Collagen III alpha 1</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen IV alpha 1">Collagen IV</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen XXIII alpha 1">Collagen XXIII alpha 1</a><br><a href="https://www.rndsystems.com/search?common_name=Collagen XXV alpha 1">Collagen XXV alpha 1</a><br> </div> </div> <div id="el146_gry" class="tcellco-signaling_all tcellco-signaling_other pw-sprite el-gray146 pw-gray" style="top:981.0000457763672px;left:632px;"> </div> <div id="el146_off" data-id="146" data-set="LAIR-190" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_other pw-sprite el-off146" style="top:981.0000457763672px;left:632px;"> </div> <div id="el146_ct" class="pw-tooltip" data-id="146"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=LAIR1">LAIR1</a><br> </div> </div> <div id="el147_gry" class="tcellco-signaling_all tcellco-signaling_other pw-label el-gray147 pw-gray" style="top:981.3333740234375px;left:668.6666870117188px;"> LAIR-1 </div> <div id="el147_off" data-id="147" data-set="LAIR-190" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_other pw-label el-off147" style="top:981.3333740234375px;left:668.6666870117188px;"> LAIR-1</div> <div id="el147_ct" class="pw-tooltip" data-id="147"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=LAIR1">LAIR1</a><br> </div> </div> <div id="el148_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label2 el-gray148 pw-gray" style="top:1023.0000610351562px;left:132px;"> Co-stimulatory </div> <div id="el148_off" data-id="148" data-set="Co-stimulatory3" data-type="" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label2 el-off148" style="top:1023.0000610351562px;left:132px;"> Co-stimulatory</div> <div id="el148_ct" class="pw-tooltip" data-id="148"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el149_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label2 el-gray149 pw-gray" style="top:1042.3333740234375px;left:12px;"> TNF Receptor Superfamily </div> <div id="el149_off" data-id="149" data-set="TNFReceptorSuperfamily" data-type="" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label2 el-off149" style="top:1042.3333740234375px;left:12px;"> TNF Receptor Superfamily </div> <div id="el149_ct" class="pw-tooltip" data-id="149"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el150_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray150 pw-gray" style="top:-450px;left:-450px;"> APC </div> <div id="el150_off" data-id="150" data-set="APC" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off150" style="top:-450px;left:-450px;"> APC</div> <div id="el150_ct" class="pw-tooltip" data-id="150"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el151_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-gray151 pw-gray" style="top:-450px;left:-450px;"> T Cell </div> <div id="el151_off" data-id="151" data-set="TCell" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel tcellco-signaling_tnfrsftypev pw-label el-off151" style="top:-450px;left:-450px;"> T Cell</div> <div id="el151_ct" class="pw-tooltip" data-id="151"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el152_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-gray152 pw-gray" style="top:-450px;left:-450px;"> Type L </div> <div id="el152_off" data-id="152" data-set="TypeL" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-off152" style="top:-450px;left:-450px;"> Type L</div> <div id="el152_ct" class="pw-tooltip" data-id="152"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el153_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-gray153 pw-gray" style="top:1091.666748046875px;left:76px;"> </div> <div id="el153_off" data-id="153" data-set="CD4096" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-off153" style="top:1091.666748046875px;left:76px;"> </div> <div id="el153_ct" class="pw-tooltip" data-id="153"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD40/TNFRSF5">CD40</a><br> </div> </div> <div id="el154_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-gray154 pw-gray" style="top:1091.666748046875px;left:42px;"> CD40 </div> <div id="el154_off" data-id="154" data-set="CD4096" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-off154" style="top:1091.666748046875px;left:42px;"> CD40</div> <div id="el154_ct" class="pw-tooltip" data-id="154"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD40/TNFRSF5">CD40</a><br> </div> </div> <div id="el155_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-gray155 pw-gray" style="top:1114.3333740234375px;left:82px;"> </div> <div id="el155_off" data-id="155" data-set="HVEM97" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-off155" style="top:1114.3333740234375px;left:82px;"> </div> <div id="el155_ct" class="pw-tooltip" data-id="155"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=HVEM/TNFRSF14">HVEM</a><br> </div> </div> <div id="el156_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-gray156 pw-gray" style="top:1116.0000610351562px;left:44px;"> HVEM </div> <div id="el156_off" data-id="156" data-set="HVEM97" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-off156" style="top:1116.0000610351562px;left:44px;"> HVEM</div> <div id="el156_ct" class="pw-tooltip" data-id="156"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=HVEM/TNFRSF14">HVEM</a><br> </div> </div> <div id="el157_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-gray157 pw-gray" style="top:1140.6667175292969px;left:88px;"> </div> <div id="el157_off" data-id="157" data-set="LIGHT98" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-off157" style="top:1140.6667175292969px;left:88px;"> </div> <div id="el157_ct" class="pw-tooltip" data-id="157"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=LIGHT/TNFSF14">LIGHT</a><br> </div> </div> <div id="el158_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-gray158 pw-gray" style="top:1143.6667175292969px;left:46.33331298828125px;"> LIGHT </div> <div id="el158_off" data-id="158" data-set="LIGHT98" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-off158" style="top:1143.6667175292969px;left:46.33331298828125px;"> LIGHT</div> <div id="el158_ct" class="pw-tooltip" data-id="158"> <div 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data-id="161"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD40 Ligand/TNFSF5">CD40 Ligand</a><br> </div> </div> <div id="el162_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-gray162 pw-gray" style="top:1094.0000610351562px;left:234.33331298828125px;"> CD40 L </div> <div id="el162_off" data-id="162" data-set="CD40L100" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-off162" style="top:1094.0000610351562px;left:234.33331298828125px;"> CD40 L</div> <div id="el162_ct" class="pw-tooltip" data-id="162"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD40 Ligand/TNFSF5">CD40 Ligand</a><br> </div> </div> <div id="el163_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-gray163 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style="top:1143.3333740234375px;left:236.33331298828125px;"> HVEM </div> <div id="el166_off" data-id="166" data-set="HVEM102" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-off166" style="top:1143.3333740234375px;left:236.33331298828125px;"> HVEM</div> <div id="el166_ct" class="pw-tooltip" data-id="166"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=HVEM/TNFRSF14">HVEM</a><br> </div> </div> <div id="el167_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-gray167 pw-gray" style="top:1167.3333740234375px;left:191.33331298828125px;"> </div> <div id="el167_off" data-id="167" data-set="DR3103" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-sprite el-off167" style="top:1167.3333740234375px;left:191.33331298828125px;"> </div> <div id="el167_ct" class="pw-tooltip" data-id="167"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=DR3/TNFRSF25">DR3</a><br> </div> </div> <div id="el168_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-gray168 pw-gray" style="top:1169.0000610351562px;left:238.33331298828125px;"> DR3 </div> <div id="el168_off" data-id="168" data-set="DR3103" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypel pw-label el-off168" style="top:1169.0000610351562px;left:238.33331298828125px;"> DR3</div> <div id="el168_ct" class="pw-tooltip" data-id="168"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=DR3/TNFRSF25">DR3</a><br> </div> </div> <div id="el169_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-gray169 pw-gray" style="top:-450px;left:-450px;"> Type V </div> <div id="el169_off" data-id="169" data-set="TypeV" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-off169" style="top:-450px;left:-450px;"> Type V</div> <div id="el169_ct" class="pw-tooltip" data-id="169"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el170_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-gray170 pw-gray" style="top:1206.3333740234375px;left:91.33331298828125px;"> </div> <div id="el170_off" data-id="170" data-set="four-1BBL105" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-off170" style="top:1206.3333740234375px;left:91.33331298828125px;"> </div> <div id="el170_ct" class="pw-tooltip" data-id="170"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=4-1BB Ligand/TNFSF9">4-1BB Ligand</a><br> </div> </div> <div id="el171_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-gray171 pw-gray" style="top:1207.0000610351562px;left:39.33331298828125px;"> 4-1BB L </div> <div id="el171_off" data-id="171" data-set="four-1BBL105" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-off171" style="top:1207.0000610351562px;left:39.33331298828125px;"> 4-1BB L</div> <div id="el171_ct" class="pw-tooltip" data-id="171"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=4-1BB Ligand/TNFSF9">4-1BB Ligand</a><br> 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tcellco-signaling_tnfrsftypev pw-label el-off173" style="top:1227.6667175292969px;left:44.33331298828125px;"> CD27 L</div> <div id="el173_ct" class="pw-tooltip" data-id="173"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD27 Ligand/TNFSF7">CD27 Ligand</a><br> </div> </div> <div id="el174_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-gray174 pw-gray" style="top:1247.6667175292969px;left:90.33331298828125px;"> </div> <div id="el174_off" data-id="174" data-set="CD30L107" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-off174" style="top:1247.6667175292969px;left:90.33331298828125px;"> </div> <div id="el174_ct" class="pw-tooltip" data-id="174"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD30 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class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-off176" style="top:1273.3333740234375px;left:87.33331298828125px;"> </div> <div id="el176_ct" class="pw-tooltip" data-id="176"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=GITR Ligand/TNFSF18">GITR Ligand</a><br> </div> </div> <div id="el177_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-gray177 pw-gray" style="top:1276.0000610351562px;left:41.33331298828125px;"> GITR L </div> <div id="el177_off" data-id="177" data-set="GITRL108" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-off177" style="top:1276.0000610351562px;left:41.33331298828125px;"> GITR L</div> <div id="el177_ct" class="pw-tooltip" data-id="177"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=GITR Ligand/TNFSF18">GITR Ligand</a><br> </div> </div> <div id="el178_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-gray178 pw-gray" style="top:1209.0000610351562px;left:193.33331298828125px;"> </div> <div id="el178_off" data-id="178" data-set="four-1BB109" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-off178" style="top:1209.0000610351562px;left:193.33331298828125px;"> </div> <div id="el178_ct" class="pw-tooltip" data-id="178"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=4-1BB/TNFRSF9/CD137">4-1BB</a><br> </div> </div> <div id="el179_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-gray179 pw-gray" style="top:1210.6667175292969px;left:237.33331298828125px;"> 4-1BB </div> <div id="el179_off" data-id="179" data-set="four-1BB109" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-off179" style="top:1210.6667175292969px;left:237.33331298828125px;"> 4-1BB</div> <div id="el179_ct" class="pw-tooltip" data-id="179"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=4-1BB/TNFRSF9/CD137">4-1BB</a><br> </div> </div> <div id="el180_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-gray180 pw-gray" style="top:1230.6667175292969px;left:192.33331298828125px;"> </div> <div id="el180_off" data-id="180" data-set="CD27110" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-off180" style="top:1230.6667175292969px;left:192.33331298828125px;"> </div> <div id="el180_ct" class="pw-tooltip" data-id="180"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD27/TNFRSF7">CD27</a><br> </div> </div> <div id="el181_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-gray181 pw-gray" style="top:1234.3333740234375px;left:238.33331298828125px;"> CD27 </div> <div id="el181_off" data-id="181" data-set="CD27110" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-off181" style="top:1234.3333740234375px;left:238.33331298828125px;"> CD27 </div> <div id="el181_ct" class="pw-tooltip" data-id="181"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD27/TNFRSF7">CD27</a><br> </div> </div> <div id="el182_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-gray182 pw-gray" style="top:1256.6667175292969px;left:192.33331298828125px;"> </div> <div id="el182_off" data-id="182" data-set="CD30111" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-sprite el-off182" style="top:1256.6667175292969px;left:192.33331298828125px;"> </div> <div id="el182_ct" class="pw-tooltip" data-id="182"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=CD30/TNFRSF8">CD30</a><br> </div> </div> <div id="el183_gry" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-gray183 pw-gray" style="top:1259.6667175292969px;left:239.33331298828125px;"> CD30 </div> <div id="el183_off" data-id="183" data-set="CD30111" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-off183" style="top:1259.6667175292969px;left:239.33331298828125px;"> CD30</div> <div id="el183_ct" class="pw-tooltip" data-id="183"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div 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data-set="GITR112" data-type="No Products Click" class="tcellco-signaling_all tcellco-signaling_tnfrsftypev pw-label el-off185" style="top:1284.3333740234375px;left:237.33331298828125px;"> GITR</div> <div id="el185_ct" class="pw-tooltip" data-id="185"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?common_name=GITR/TNFRSF18">GITR</a><br> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/tcellcosignaling_bkgrd.png?t=5" alt="T Cell Co-Signaling Pathway: Ligand-Receptor Interactions" style="height:1335px"> </div> </div> <div id="pathway-description"><h2>Overview of T Cell Co-signaling Ligand-Receptor Interactions</h2><p><p>T cell activation requires two signals: 1) recognition of the antigenic peptide/major histocompatibility complex (MHC) by the T cell receptor (TCR) and 2) antigen-independent co-stimulation induced by interactions between co-signaling molecules expressed on antigen-presenting cells (APCs) and their T cell-expressed receptors. Engagement of the TCR in the absence of this second co-stimulatory signal typically results in T cell anergy or apoptosis. In addition, T cell activation can be negatively regulated by co-inhibitory molecules present on APCs. Therefore, integration of the signals transduced by co-stimulatory and co-inhibitory molecules following TCR engagement directs the outcome and magnitude of a T cell response including the enhancement or suppression of T cell proliferation, differentiation, and/or cytokine secretion. Most co-stimulatory and co-inhibitory molecules belong to either the Immunoglobulin (Ig) superfamily or Tumor Necrosis Factor (TNF) receptor superfamily and are further classified as members of the B7/CD28, butyrophilin, CD2/SLAM, TIM, or CD226 subfamilies of the Ig superfamily or as members of the type L or type V subfamilies of the TNF receptor superfamily. Many of these proteins are being investigated as potential targets for cancer immunotherapy as multiple studies have shown that the T cell co-stimulatory/co-inhibitory system can be exploited to improve anti-tumor immunity.</p> <p>B7 proteins are a family of co-signaling molecules that primarily interact with T cell-expressed immune receptors belonging to the CD28 family (CD28, CTLA-4, PD-1, ICOS, and BTLA). Interactions between B7 and CD28 family members transduce both T cell co-stimulatory and co-inhibitory signals. Additionally, these interactions can have bidirectional effects (indicated by the two-headed arrows in the graphic). The B7 family consists of ten surface glycoproteins including B7-1/CD80, B7-2/CD86, B7-H1/PD-L1, B7-DC/PD-L2, B7-H2/ICOS L, B7-H3, B7-H4, B7-H5/VISTA, B7-H6, and B7-H7/HHLA2. Of these, B7-1/CD80 and B7-2/CD86 have been the most widely studied. Both B7-1/CD80 and B7-2/CD86 are expressed on APCs and can bind to T cell-expressed CD28 or CTLA-4. CD28 is constitutively expressed on na茂ve T cells and its interaction with B7-1/CD80 or B7-2/CD86 promotes T cell activation. In contrast, CTLA-4 expression is induced 24-48 hours following T cell activation. It binds to both B7-1/CD80 and B7-2/CD86 with higher affinity than CD28 and produces a co-inhibitory signal that down regulates the T cell response. B7-H1/PD-L1 and PD-L2/B7-DC also function as co-inhibitory molecules by signaling through the T cell-expressed PD-1 receptor. Significantly, blocking antibodies against CTLA-4, PD-1, or PD-L1 have been shown to improve the immune response in multiple different cancer models. Other B7 family proteins deliver co-stimulatory or co-inhibitory signals by binding to ICOS (B7-H2/ICOS L) or currently unidentified receptors (B7-H4, B7-H5/VISTA, B7-H7/HHLA2) as shown in the graphic. B7-H6 is an exception because unlike other B7 family proteins, it binds to the NKp30 activating receptor on natural killer cells (not shown). The BTLA protein is also distinct from other CD28 family receptors as it binds to the TNF receptor superfamily member, HVEM, to inhibit T cell activation.</p> <p>Structurally, the butyrophilins are closely related to the B7 family proteins and appear to have similar immunomodulatory functions. To date, thirteen human butyrophilin proteins have been identified including BTN1A1, BTN2A1, BTN2A2, BTN2A3, BTN3A1, BTN3A2, BTN3A3, and the butyrophilin-like proteins, BTNL2, BTNL3, BTNL8, BTNL9, BTNL10, and SKINT-like (SKINTL). With the exception of BTNL2 and BTN3A2, butyrophilins are type I transmembrane proteins that contain one IgV-like and one IgC-like domain in their extracellular regions and a cytoplasmic B30.2 domain. The presence of this domain distinguishes the butyrophilins from the B7 family. Unlike other butyrophilins, BTNL2 has two extracellular IgV- and IgC-like domains and lacks the intracellular B30.2 domain, which is also absent in BTN3A2. Most butyrophilin proteins that have been characterized to date, including human BTN1A1, BTN2A2, BTN3A1, BTNL2, and mouse BTNL1, act through unidentified receptors to inhibit T cell proliferation and cytokine production. The exception is BTNL8 which enhances T cell proliferation and cytokine secretion. Further investigation is necessary to identify the butyrophilin receptors and determine the functions of the other butyrophilin family members.</p> <p>Several members of the CD2/signaling lymphocyte activation molecule (SLAM) family of proteins have also been shown to regulate T cell co-signaling. The SLAM family currently consists of nine members, SLAM/CD150, CD48/SLAMF2, Ly9/SLAMF3, 2B4/SLAMF4, CD84/SLAMF5, NTB-A/SLAMF6/Ly108, CRACC/SLAMF7, BLAME, SLAMF8, and CD2F-10/SLAMF9. These proteins contain two or four extracellular Ig-like domains and most contain a cytoplasmic domain known as the immunoreceptor tyrosine-based switch motif (ITSM). SLAM family receptors are expressed on a variety of hematopoietic cell types including T cells, B cells, and dendritic cells and most are capable of homotypic interactions, allowing them to act as self-ligands. T cell activation is induced by homotypic interactions between APC- and T cell-expressed SLAM/CD150 and by binding of APC-expressed CD48/SLAMF2 (mice and rats) or CD58/LFA-3 (humans) to T cell-expressed CD2. Ly9/SLAMF3 and NTB-A/SLAMF6 also seem to function as T cell activating receptors. In contrast, CD48/SLAMF2 can inhibit T cell activation through an interaction with 2B4/SLAMF4. More research is needed to determine if other CD2/SLAM family proteins affect T cell co-signaling.</p> <p>The T cell/transmembrane, immunoglobulin, and mucin (TIM) family and nectin- or nectin-like-binding receptors (CD226) are two additional subfamilies of IgSF molecules that regulate T cell activation. In humans, the TIM family consists of TIM-1, TIM-3, and TIM-4. TIM-4 is exclusively expressed on APCs and has both co-stimulatory and co-inhibitory effects on T cell activation. Binding of TIM-4 on APCs to TIM-1 on activated T cells promotes T cell proliferation and cytokine production. In contrast, TIM-4 has an inhibitory effect on na茂ve T cells, which do not express TIM-1, suggesting that TIM-4 can act through a currently unidentified receptor to prevent na茂ve T cell proliferation. The interaction between T cell-expressed TIM-3 and its ligand, Galectin-9, also inhibits T cell responses.</p> <p>Nectin or nectin-like-binding receptors including DNAM-1/CD226, TIGIT, CRTAM, and CD96 are a new group of IgSF members that regulate the activities of CD8+ T cells and natural killer (NK) cells. DNAM-1/CD226 is expressed on several lymphoid and myeloid cell types and interacts with CD155/PVR or Nectin-2/CD112, which promotes the activation of CD8+ T cells and NK cells. TIGIT also binds Nectin-2/CD112 and CD155/PVR and can antagonize the effects of DNAM-1/CD226. TIGIT is primarily expressed on activated CD4+ and CD8+ T cells and ligation of TIGIT down regulates TCR-mediated activation and proliferation.</p> <p>Several TNF receptor superfamily members have also been shown to affect T cell co-signaling. These proteins are characterized as type L or type V receptors based on their structures. A subset of members from the type L subfamily and all of the type V receptor subfamily have co-stimulatory activities. These include CD40/TNFRSF5, HVEM/TNFRSF14 (binding to Lymphotoxin alpha or LIGHT/TNFSF14), and DR3/TNFRSF25 from the type L subfamily, and 4-1BB/TNFRSF9, CD27/TNFRSF7, CD30/TNFRSF8, GITR/TNFRSF18, and OX40/TNFSF4 from the type V subfamily. HVEM/TNFRSF14 can also have co-inhibitory effects on T cell activation through its interactions with CD160 and BTLA.</p> <p>To learn more, explore the following T cell co-signaling-related resources:</p> <p><a href="https://www.bio-techne.com/content/current-and-emerging-immune-checkpoint-targets-immuno-oncology-research-ebook" target="_blank">Current and Emerging Immune Checkpoint Targets for Immuno-Oncology Research eBook</a></p> <p><a href="/research-area/co--stimulatory-and-co--inhibitory-molecules">Co-stimulatory and Co-inhibitory Molecules Research Area</a></p> <p><a href="/product-highlights/b7-cd28-family-immune-checkpoint-proteins">B7-CD28 Family of Immune Checkpoint Proteins</a></p> <p><a href="/products/bioactive-proteins-immune-checkpoint">Bioactive Proteins: Immune Checkpoint</a></p> <p><a href="/products/recombinant-cynomolgus-monkey-and-rhesus-macaque-proteins">Non-Human Primate Recombinant Proteins</a></p> <p><a href="/products/active-biotinylated-proteins">Avi-tag 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value="NI">Nicaragua</option><option value="NE">Niger</option><option value="NG">Nigeria</option><option value="MP">Northern Mariana Islands</option><option value="NO">Norway</option><option value="OM">Oman</option><option value="PK">Pakistan</option><option value="PW">Palau</option><option value="PA">Panama</option><option value="PG">Papua New Guinea</option><option value="PY">Paraguay</option><option value="PE">Peru</option><option value="PH">Philippines</option><option value="PL">Poland</option><option value="PT">Portugal</option><option value="PR">Puerto Rico</option><option value="QA">Qatar</option><option value="RO">Romania</option><option value="RW">Rwanda</option><option value="KN">Saint Kitts and Nevis</option><option value="LC">Saint Lucia</option><option value="MF">Saint Martin (French part)</option><option value="WS">Samoa</option><option value="SA">Saudi Arabia</option><option value="SN">Senegal</option><option value="RS">Serbia</option><option value="SL">Sierra 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