Nadia Ameen, MBBS < Yale School of Medicine

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Journal Of Cystic Fibrosis 2024, 23: s185. <a href=\"https://doi.org/10.1016/s1569-1993(24)01194-9\" target=\"_blank\">DOI: 10.1016/s1569-1993(24)01194-9</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocort","url":"https://pubmed.ncbi.nlm.nih.gov/38925289","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. 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Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta. European Journal Of Pharmacology 2024, 978: 176771. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38925289\" target=\"_blank\">PMID: 38925289</a>, <a href=\"https://doi.org/10.1016/j.ejphar.2024.176771\" target=\"_blank\">DOI: 10.1016/j.ejphar.2024.176771</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE","url":"https://doi.org/10.1016/s0016-5085(24)02489-2","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE. Gastroenterology 2024, 166: s-874. <a href=\"https://doi.org/10.1016/s0016-5085(24)02489-2\" target=\"_blank\">DOI: 10.1016/s0016-5085(24)02489-2</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE","url":"https://doi.org/10.1016/s0016-5085(24)01027-8","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Gastroenterology 2024, 166: s-236. <a href=\"https://doi.org/10.1016/s0016-5085(24)01027-8\" target=\"_blank\">DOI: 10.1016/s0016-5085(24)01027-8</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse int","url":"https://doi.org/10.1016/s1569-1993(23)01478-9","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. 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We provide conventional standard of care along side nutritional promotion as needed, but focus on foods, exercise, stress reduction and lifestyle as a primary modalities for disease treatment and prevention.","url":"https://medicine.yale.edu/profile/nadia-ameen/","email":"nadia.ameen@yale.edu","telephone":"+12037854649","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/5ba2217e-1c37-4041-ba87-0bcf94304a7a","description":"YSM7217_0124_N_Ameen","height":1200,"width":630,"@context":"http://schema.org"},"address":[{"@type":"PostalAddress","addressCountry":"United States","addressLocality":"New Haven","addressRegion":"CT","postalCode":"06520-8064","streetAddress":"PO Box 208064","@context":"http://schema.org"}],"workLocation":[{"@type":"Place","name":"The Anlyan Center","address":{"@type":"PostalAddress","addressCountry":"United States","addressLocality":"New Haven","addressRegion":"CT","postalCode":"06519","streetAddress":"300 Cedar Street, Ste S-160","@context":"http://schema.org"},"@context":"http://schema.org"}],"honorificSuffix":["MBBS"],"award":["NASPGHAN Award for Study of Disorders Associated with Carbohydrate Malabsorption 2020"],"jobTitle":["Professor of Pediatrics (Gastroenterology)"],"affiliation":[{"@type":"Organization","name":"Ameen Lab","url":"https://medicine.yale.edu/lab/ameen/","@context":"http://schema.org"},{"@type":"Organization","name":"Cellular & Molecular Physiology","url":"https://medicine.yale.edu/physiology/","@context":"http://schema.org"},{"@type":"Organization","name":"Discovery to Cure Internship","@context":"http://schema.org"},{"@type":"Organization","name":"Molecular Medicine, Pharmacology, and Physiology","url":"https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatric Colorectal Disorders Program","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatric Gastroenterology & Hepatology","url":"https://medicine.yale.edu/pediatrics/sections/gastroenterology-hepatology/","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatric Healthy Gut & Constipation Program","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatrics","url":"https://medicine.yale.edu/pediatrics/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Institute for Global Health","url":"https://medicine.yale.edu/yigh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"University of West Indies (1985)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"<strong data-id=\"69022\">Ameen N</strong>, Dastoor P, dos Reis D, Barone C, <span data-id=\"128611\">Garrison A</span>, Egan M. 555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse intestine. Journal Of Cystic Fibrosis 2023, 22: s293-s294. <a href=\"https://doi.org/10.1016/s1569-1993(23)01478-9\" target=\"_blank\">DOI: 10.1016/s1569-1993(23)01478-9</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"539 Role of CFTR high expresser cells in cystic fibrosis intestinal disease","url":"https://doi.org/10.1016/s1569-1993(23)01462-5","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. My research interest is focused on mechanisms responsible for diarrheal diseases. My lab primarily investigates mechanisms regulating the CFTR chloride channel in the intestine and how these are linked to genetic, and non-genetic diarrheal diseases and Cystic Fibrosis (CF). We elucidated trafficking mechanisms regulating CFTR that are implicated in diarrhea that are the basis for successful drug therapies to treat constipation and increase intestinal fluidity (Linaclotide, Lubiprostone). Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children. My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. 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Journal Of Cystic Fibrosis 2023, 22: s285. <a href=\"https://doi.org/10.1016/s1569-1993(23)01462-5\" target=\"_blank\">DOI: 10.1016/s1569-1993(23)01462-5</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"CFTR High Expresser Cells in cystic fibrosis and intestinal diseases","url":"https://pubmed.ncbi.nlm.nih.gov/36967909","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. My research interest is focused on mechanisms responsible for diarrheal diseases. My lab primarily investigates mechanisms regulating the CFTR chloride channel in the intestine and how these are linked to genetic, and non-genetic diarrheal diseases and Cystic Fibrosis (CF). We elucidated trafficking mechanisms regulating CFTR that are implicated in diarrhea that are the basis for successful drug therapies to treat constipation and increase intestinal fluidity (Linaclotide, Lubiprostone). Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children. My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. We provide conventional standard of care along side nutritional promotion as needed, but focus on foods, exercise, stress reduction and lifestyle as a primary modalities for disease treatment and prevention.","url":"https://medicine.yale.edu/profile/nadia-ameen/","email":"nadia.ameen@yale.edu","telephone":"+12037854649","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/5ba2217e-1c37-4041-ba87-0bcf94304a7a","description":"YSM7217_0124_N_Ameen","height":1200,"width":630,"@context":"http://schema.org"},"address":[{"@type":"PostalAddress","addressCountry":"United States","addressLocality":"New Haven","addressRegion":"CT","postalCode":"06520-8064","streetAddress":"PO Box 208064","@context":"http://schema.org"}],"workLocation":[{"@type":"Place","name":"The Anlyan Center","address":{"@type":"PostalAddress","addressCountry":"United States","addressLocality":"New Haven","addressRegion":"CT","postalCode":"06519","streetAddress":"300 Cedar Street, Ste S-160","@context":"http://schema.org"},"@context":"http://schema.org"}],"honorificSuffix":["MBBS"],"award":["NASPGHAN Award for Study of Disorders Associated with Carbohydrate Malabsorption 2020"],"jobTitle":["Professor of Pediatrics (Gastroenterology)"],"affiliation":[{"@type":"Organization","name":"Ameen Lab","url":"https://medicine.yale.edu/lab/ameen/","@context":"http://schema.org"},{"@type":"Organization","name":"Cellular & Molecular Physiology","url":"https://medicine.yale.edu/physiology/","@context":"http://schema.org"},{"@type":"Organization","name":"Discovery to Cure Internship","@context":"http://schema.org"},{"@type":"Organization","name":"Molecular Medicine, Pharmacology, and Physiology","url":"https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatric Colorectal Disorders Program","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatric Gastroenterology & Hepatology","url":"https://medicine.yale.edu/pediatrics/sections/gastroenterology-hepatology/","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatric Healthy Gut & Constipation Program","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatrics","url":"https://medicine.yale.edu/pediatrics/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Institute for Global Health","url":"https://medicine.yale.edu/yigh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"University of West Indies (1985)","@context":"http://schema.org"}],"sameAs":[],"@context":"http://schema.org"}],"description":"dos Reis D, Dastoor P, Santos A, <span data-id=\"121074\">Sumigray K</span>, <strong data-id=\"69022\">Ameen N</strong>. CFTR High Expresser Cells in cystic fibrosis and intestinal diseases. Heliyon 2023, 9: e14568. <a href=\"https://pubmed.ncbi.nlm.nih.gov/36967909\" target=\"_blank\">PMID: 36967909</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031467\" target=\"_blank\">PMCID: PMC10031467</a>, <a href=\"https://doi.org/10.1016/j.heliyon.2023.e14568\" target=\"_blank\">DOI: 10.1016/j.heliyon.2023.e14568</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusi","url":"https://pubmed.ncbi.nlm.nih.gov/35887942","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. 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Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID). Journal Of Clinical Medicine 2022, 11: 4179. <a href=\"https://pubmed.ncbi.nlm.nih.gov/35887942\" target=\"_blank\">PMID: 35887942</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319011\" target=\"_blank\">PMCID: PMC9319011</a>, <a href=\"https://doi.org/10.3390/jcm11144179\" target=\"_blank\">DOI: 10.3390/jcm11144179</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348250","author":[{"@type":"Person","name":"Nadia Ameen","description":"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells. The FASEB Journal 2022, 36: 10.1096/fasebj.2022.36.s1.0r556. <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348250\" target=\"_blank\">PMCID: PMC9348250</a>, <a href=\"https://doi.org/10.1096/fasebj.2022.36.s1.0r556\" target=\"_blank\">DOI: 10.1096/fasebj.2022.36.s1.0r556</a>.","@context":"http://schema.org"} </script> <script type="text/javascript"> (function (c, a) { if (!a.__SV) { var b = window; try { var d, m, j, k = b.location, f = k.hash; d = function (a, b) { return (m = a.match(RegExp(b + "=([^&]*)"))) ? m[1] : null }; f && d(f, "fpState") && (j = JSON.parse(decodeURIComponent(d(f, "fpState"))), "fpeditor" === j.action && (b.sessionStorage.setItem("_fpcehash", f), history.replaceState(j.desiredHash || "", c.title, k.pathname + k.search))) } catch (n) { } var l, h; window.freshpaint = a; a._i = []; a.init = function (b, d, g) { function c(b, i) { var a = i.split("."); 2 == a.length && (b = b[a[0]], i = a[1]); b[i] = function () { b.push([i].concat(Array.prototype.slice.call(arguments, 0))) } } var e = a; "undefined" !== typeof g ? e = a[g] = [] : g = "freshpaint"; e.people = e.people || []; e.toString = function (b) { var a = "freshpaint"; "freshpaint" !== g && (a += "." + g); b || (a += " (stub)"); return a }; e.people.toString = function () { return e.toString(1) + ".people (stub)" }; l = "disable time_event track track_pageview track_links track_forms track_with_groups add_group set_group remove_group register register_once alias unregister identify name_tag set_config reset opt_in_tracking opt_out_tracking has_opted_in_tracking has_opted_out_tracking clear_opt_in_out_tracking people.set people.set_once people.unset people.increment people.append people.union people.track_charge people.clear_charges people.delete_user people.remove people group page alias ready addEventProperties addInitialEventProperties removeEventProperty addPageviewProperties".split(" "); for (h = 0; h < l.length; h++)c(e, l[h]); var f = "set set_once union unset remove delete".split(" "); e.get_group = function () { function a(c) { b[c] = function () { call2_args = arguments; call2 = [c].concat(Array.prototype.slice.call(call2_args, 0)); e.push([d, call2]) } } for (var b = {}, d = ["get_group"].concat(Array.prototype.slice.call(arguments, 0)), c = 0; c < f.length; c++)a(f[c]); return b }; a._i.push([b, d, g]) }; a.__SV = 1.4; b = c.createElement("script"); b.type = "text/javascript"; b.async = !0; b.src = "undefined" !== typeof FRESHPAINT_CUSTOM_LIB_URL ? 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5.53 0 0 0 6.884-.755l.774-.774a1.846 1.846 0 0 0 0-2.609L19.449 15a1.846 1.846 0 0 0-2.609 0h0a1.843 1.843 0 0 1-2.608 0L9.014 9.781a1.846 1.846 0 0 1 0-2.609h0a1.843 1.843 0 0 0 0-2.608L5.754 1.3a1.846 1.846 0 0 0-2.609 0l-.774.774a5.535 5.535 0 0 0-.756 6.884l.008.012A49.9 49.9 0 0 0 15.04 22.39" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg><div class="profile-details-contact-header-card__row-title"><a href="tel:+12037854649" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--navy link--font--normal link--decorate-color--light-blue" aria-label="Academic Office 203.785.4649"><span class="link__label">203.785.4649</span></a></div></div><div class="profile-details-header-card-with-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-header-card-with-icon__icon"><circle cx="12" cy="7.5" r="3" 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profile-details-section-content--with-empty-sidebar"><div class="profile-details-section-content__main"><div><section class="profile-details-content-section" aria-label="about Titles" id="about-titles" tabindex="-1"><h3 class="profile-details-content-section__heading">Titles</h3><div class="profile-details-content-section__content"><p class="profile-details-about-section-content__workday-title">Professor of Pediatrics (Gastroenterology)</p><p class="profile-details-about-section-content__custom-title">Affiliated Faculty, Yale Institute for Global Health</p></div></section><section class="profile-details-content-section" aria-label="about Biography" id="about-biography" tabindex="-1"><h3 class="profile-details-content-section__heading">Biography</h3><div class="profile-details-content-section__content"><div class="profile-details-html-content-section__content"><p>I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. My research interest is focused on mechanisms responsible for <strong><em>diarrheal diseases.</em></strong> My lab primarily investigates mechanisms regulating the CFTR chloride channel in the intestine and how these are linked to genetic, and non-genetic diarrheal diseases and Cystic Fibrosis (CF). We elucidated trafficking mechanisms regulating CFTR that are implicated in diarrhea that are the basis for successful drug therapies to treat constipation and increase intestinal fluidity (Linaclotide, Lubiprostone). Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children. </p> <p>My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. We provide conventional standard of care along side nutritional promotion as needed, but focus on foods, exercise, stress reduction and lifestyle as a primary modalities for disease treatment and prevention. </p> <p></p> <p> </p></div></div></section><section class="profile-details-content-section" aria-label="about Appointments" id="about-appointments" tabindex="-1"><h3 class="profile-details-content-section__heading">Appointments</h3><div class="profile-details-content-section__content"><div class="profile-details-appointment-list"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Professor Primary in Pediatric Gastroenterology & Hepatology"><h4 class="profile-details-appointment-card__academic-unit">Pediatric Gastroenterology & Hepatology</h4><div class="profile-details-appointment-card__title">Professor</div><div class="profile-details-appointment-card__type">Primary</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/pediatrics/sections/gastroenterology-hepatology/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Pediatric Gastroenterology & Hepatology</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Professor Secondary in Cellular & Molecular Physiology"><h4 class="profile-details-appointment-card__academic-unit">Cellular & Molecular Physiology</h4><div class="profile-details-appointment-card__title">Professor</div><div class="profile-details-appointment-card__type">Secondary</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/physiology/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Cellular & Molecular Physiology</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div></article></li></ul></div><h4 class="profile-details-organization-list__header">Other Departments & Organizations</h4><div class="profile-details-organization-list__list"><ul><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/lab/ameen/" tabindex="0" class="hyperlink">Ameen Lab</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/physiology/" tabindex="0" class="hyperlink">Cellular & Molecular Physiology</a></li><li class="organization-hyperlink-list__item"><span>Discovery to Cure Internship</span></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/" tabindex="0" class="hyperlink">Molecular Medicine, Pharmacology, and Physiology</a></li><li class="organization-hyperlink-list__item"><span>Pediatric Colorectal Disorders Program</span></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/pediatrics/sections/gastroenterology-hepatology/" tabindex="0" class="hyperlink">Pediatric Gastroenterology & Hepatology</a></li><li class="organization-hyperlink-list__item"><span>Pediatric Healthy Gut & Constipation Program</span></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/pediatrics/" tabindex="0" class="hyperlink">Pediatrics</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/bbs/" tabindex="0" class="hyperlink">Yale Combined Program in the Biological and Biomedical Sciences (BBS)</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/yigh/" tabindex="0" class="hyperlink">Yale Institute for Global Health</a></li><li class="organization-hyperlink-list__item"><a href="https://ventures.yale.edu/" tabindex="0" class="hyperlink">Yale Ventures</a></li></ul></div></div></section><section class="profile-details-content-section" aria-label="about Education & Training" id="about-education-and-training" tabindex="-1"><h3 class="profile-details-content-section__heading">Education & Training</h3><div class="profile-details-content-section__content"><div class="profile-details-education-list"><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker profile-details-education-list__marker--last"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">MBBS</dt><dd class="profile-details-education-list__institution">University of West Indies (1985)</dd></dl></div></div></div></section></div></div><div class="profile-details-section-content__sidebar"></div></div></section><section id="research-details-section" aria-label="Research"><header class="profile-details-section-header"><div class="heading__container"><h2 class="profile-details-section-header__heading" tabindex="-1" id="research">Research</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--light"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></header><div class="profile-details-section-content profile-details-research-section__content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="research Overview" id="research-overview" tabindex="-1"><h3 class="profile-details-content-section__heading">Overview</h3><div class="profile-details-content-section__content"><div class="profile-details-research-section-overview__description"><p xmlns="http://www.w3.org/1999/xhtml">Our early studies focussed on identification of trafficking as a major mechanism regulating CFTR in the intestine and its relevance to secretory diarrhea. More recently, we investigate a rare genetic diarrheal disease that affect new borns, Microvillus Inclusion Disease(MVID). We were first to show that MVID results from an apical trafficking defect. Current investigations are elucidating kinase signaling mechanisms regulating ion transport that result in diarrhea in MVID. </p></div><section class="profile-details-research-section-overview__keyword-container" aria-label="MeSH keyword list"><h4 class="profile-details-research-section-overview__keyword-heading">Medical Subject Headings (MeSH)</h4><div class="profile-details-research-section-overview__keyword">Antidiarrheals; Intestinal Diseases</div></section></div></section></div><div class="profile-details-section-content__sidebar"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-lab" aria-label="Lab Website"><div class="profile-details-lab__header"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="-0.5 -0.5 20 20" focusable="false" class="profile-details-lab__icon"><desc>Lab Whisk Cup Streamline Icon: https://streamlinehq.com</desc><path stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" d="M11.265 5.146H3.776a.4.4 0 0 0-.356.221.4.4 0 0 0 .047.42l.895 1.116a.8.8 0 0 1 .174.5v9.618a1.583 1.583 0 0 0 1.584 1.583h7.916a1.583 1.583 0 0 0 1.584-1.583V5.54a.396.396 0 0 0-.396-.395h-.792"></path><path stroke="currentColor" stroke-linecap="round" stroke-linejoin="round" d="M10.672 17.02a1.385 1.385 0 1 0 0-2.77 1.385 1.385 0 0 0 0 2.77M11.075 14.313 13.64.396M4.536 11.875h5.146M11.519 11.875h4.1M4.536 9.5H6.12M4.536 16.625H6.12M4.536 14.25H6.12"></path><g stroke="currentColor"><path d="M9.848.99a.198.198 0 1 1 0-.396M9.848.99a.198.198 0 1 0 0-.396"></path></g><g stroke="currentColor"><path d="M8.265 3.365a.198.198 0 1 1 0-.396M8.265 3.365a.198.198 0 1 0 0-.396"></path></g><g stroke="currentColor"><path d="M10.094 7.125a.198.198 0 1 1 0-.396M10.094 7.125a.198.198 0 1 0 0-.396"></path></g><g stroke="currentColor"><path d="M8.89 9.698a.198.198 0 1 1 0-.396M8.89 9.698a.198.198 0 1 0 0-.396"></path></g></svg><h3 class="profile-details-lab__title">Ameen Lab</h3></div><a href="https://medicine.yale.edu/lab/ameen/index.aspx" tabindex="0" class="button button--large button--secondary button--color-mode--blue button--link"><span class="button__label">View Lab Website</span></a></article></li></ul></div></div><div class="profile-details-section-content profile-details-section-content--without-sidebar profile-details-research-section__content profile-details-research-section__glance-content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="research Research at a Glance" id="research-research-at-a-glance" tabindex="-1"><h3 class="profile-details-content-section__heading">Research at a Glance</h3><div class="profile-details-content-section__content"><div class="profile-details-glance-list"><div class="profile-details-glance-list__description-column"><div class="slick-slider slick-initialized" dir="ltr"><div class="slick-list"><div class="slick-track" style="width:500%;left:-100%"><div data-index="0" class="slick-slide slick-active slick-current" tabindex="-1" aria-hidden="false" style="outline:none;width:20%;position:relative;left:0;opacity:1;z-index:999;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Yale Co-Authors</h4><div class="profile-details-glance-description__content">Frequent collaborators of Nadia Ameen's published research.</div></div></div></div><div data-index="1" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:20%;position:relative;left:-20px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Publications Timeline</h4><div class="profile-details-glance-description__content">A big-picture view of Nadia Ameen's research output by year.</div></div></div></div></div></div></div><div class="profile-details-glance-list__navigation"><div class="profile-details-slider-navigation profile-details-slider-navigation--color-mode--dark"><button class="profile-details-slider-navigation__arrow-button" type="button" aria-label="Go to slide Publications Timeline"><span class="slider-navigation__icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-slider-navigation__arrow-button-icon"><path d="M.757 12h22.486M12.743 1 1.1 11.249a1 1 0 0 0 0 1.5L12.743 23" 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class="profile-details-glance-list__content-column"><div class="profile-details-glance-list__content"><div class="slick-slider slick-initialized" dir="ltr"><div class="slick-list"><div class="slick-track" style="width:500%;left:-100%"><div data-index="0" class="slick-slide slick-active slick-current" tabindex="-1" aria-hidden="false" style="outline:none;width:20%;position:relative;left:0;opacity:1;z-index:999;transition:opacity 250ms ease, visibility 250ms ease"><div><div tabindex="-1" style="width:100%;display:inline-block"><section class="profile-details-coauthors-glance" aria-label="Paged coauthors list"><div class="profile-details-coauthors-glance__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Kaelyn Sumigray, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:100px;height:100px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Kaelyn Sumigray, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/kaelyn-sumigray/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Kaelyn Sumigray, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" 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profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">John Geibel, DSc, MD, AGAF, MS, FRS</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/john-geibel/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to John Geibel, DSc, MD, AGAF, MS, FRS's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&profilePageName=john-geibel" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between John Geibel, DSc, MD, AGAF, MS, FRS and Nadia Ameen">View 3 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Alannah Garrison"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:40px;height:40px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Alannah Garrison</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/alannah-garrison/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal 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class="profile-details-coauthor" aria-label="Co-author Amos Brooks, HT (ASCP)"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:40px;height:40px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Amos Brooks, HT (ASCP)</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/amos-brooks/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Amos Brooks, HT (ASCP)'s details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&profilePageName=amos-brooks" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Amos Brooks, HT (ASCP) and Nadia Ameen">View 2 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Mark Mooseker, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:40px;height:40px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Mark Mooseker, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/mark-mooseker/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Mark Mooseker, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&profilePageName=mark-mooseker" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Mark Mooseker, PhD and Nadia Ameen">View 2 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Timothy Nottoli, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:40px;height:40px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Timothy Nottoli, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/timothy-nottoli/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Timothy Nottoli, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg 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class="profile-details-content-section__heading">Publications</h3><div class="profile-details-content-section__content"><section class="profile-publication-card-grouped-list__section" aria-label="2024 Group"><h4 class="profile-publication-card-grouped-list__section-title">2024</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/s1569-1993(24)01153-6" class="profile-publication-card__link">313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine</a></h5><cite class="profile-publication-card__citation">Jin J, dos Reis D, Muiler C, Zagoren E, Donnelley M, Parsons D, <span data-id="121074">Sumigray K</span>, <strong data-id="69022">Ameen N</strong>. 313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine. Journal Of Cystic Fibrosis 2024, 23: s167. <a href="https://doi.org/10.1016/s1569-1993(24)01153-6" target="_blank">DOI: 10.1016/s1569-1993(24)01153-6</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-0" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-0" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-0" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CHE%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CHE cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=High-expressing%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">High-expressing cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CF%20intestine" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CF intestine</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Expressing%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Expressing cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Luminal%20pH" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Luminal pH</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="354 Elucidating the role of signaling and stress on CFTR and its contribution to diarrhea in SGK1 knockout mouse intestine"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/s1569-1993(24)01194-9" class="profile-publication-card__link">354 Elucidating the role of signaling and stress on CFTR and its contribution to diarrhea in SGK1 knockout mouse intestine</a></h5><cite class="profile-publication-card__citation">Muiler C, Santos A, Dastoor P, Jin J, dos Reis D, Hoque K, <strong data-id="69022">Ameen N</strong>. 354 Elucidating the role of signaling and stress on CFTR and its contribution to diarrhea in SGK1 knockout mouse intestine. Journal Of Cystic Fibrosis 2024, 23: s185. <a href="https://doi.org/10.1016/s1569-1993(24)01194-9" target="_blank">DOI: 10.1016/s1569-1993(24)01194-9</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-1" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-1" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-1" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Mouse%20intestine" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mouse intestine</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38925289" class="profile-publication-card__link">Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta</a></h5><cite class="profile-publication-card__citation">Dastoor P, Muiler C, <span data-id="128611">Garrison A</span>, Egan M, Carlos Dos Reis D, Santos A, <strong data-id="69022">Ameen N</strong>. Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta. European Journal Of Pharmacology 2024, 978: 176771. <a href="https://pubmed.ncbi.nlm.nih.gov/38925289" target="_blank">PMID: 38925289</a>, <a href="https://doi.org/10.1016/j.ejphar.2024.176771" target="_blank">DOI: 10.1016/j.ejphar.2024.176771</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-2" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-2" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-2" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Serum%20glucocorticoid%20kinase%201" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Serum glucocorticoid kinase 1</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Glucocorticoid%20kinase%201" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Glucocorticoid kinase 1</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=F508del-CFTR" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">F508del-CFTR</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Cystic%20fibrosis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cystic fibrosis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Mouse%20model" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mouse model</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=F508del-CFTR%20mice" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">F508del-CFTR mice</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CFTR-expressing%20epithelial%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CFTR-expressing epithelial cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CF%20mouse%20models" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CF mouse models</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Humanized%20mouse%20model" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Humanized mouse model</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Treatment%20of%20rats" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Treatment of rats</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Intestinal%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intestinal disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Intestinal%20segments" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intestinal segments</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Kinase%201" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Kinase 1</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CFTR%20modulators" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CFTR modulators</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CFTR%20mutations" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CFTR mutations</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CF%20patients" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CF patients</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Trikafta" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Trikafta</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Dex%20treatment" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Dex treatment</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Lung%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Lung disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Efficacy%20of%20compounds" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Efficacy of compounds</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Delta%20F508" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Delta F508</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CFTR" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CFTR</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Combined%20treatment" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Combined treatment</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Epithelial%20cells" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Epithelial cells</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Loss%20of%20function" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Loss of function</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/s0016-5085(24)02489-2" class="profile-publication-card__link">Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE</a></h5><cite class="profile-publication-card__citation">Muiler C, Santos A, Dastoor P, Jin J, Reis D, Kazi M, <strong data-id="69022">Ameen N</strong>. Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE. Gastroenterology 2024, 166: s-874. <a href="https://doi.org/10.1016/s0016-5085(24)02489-2" target="_blank">DOI: 10.1016/s0016-5085(24)02489-2</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/s0016-5085(24)01027-8" class="profile-publication-card__link">978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE</a></h5><cite class="profile-publication-card__citation">Jin J, Reis D, Muiler C, <span data-id="121074">Sumigray K</span>, <strong data-id="69022">Ameen N</strong>. 978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE. Gastroenterology 2024, 166: s-236. <a href="https://doi.org/10.1016/s0016-5085(24)01027-8" target="_blank">DOI: 10.1016/s0016-5085(24)01027-8</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div></article></li></ul></section><section class="profile-publication-card-grouped-list__section" aria-label="2023 Group"><h4 class="profile-publication-card-grouped-list__section-title">2023</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse intestine"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/s1569-1993(23)01478-9" class="profile-publication-card__link">555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse intestine</a></h5><cite class="profile-publication-card__citation"><strong data-id="69022">Ameen N</strong>, Dastoor P, dos Reis D, Barone C, <span data-id="128611">Garrison A</span>, Egan M. 555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse intestine. Journal Of Cystic Fibrosis 2023, 22: s293-s294. <a href="https://doi.org/10.1016/s1569-1993(23)01478-9" target="_blank">DOI: 10.1016/s1569-1993(23)01478-9</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-3" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-3" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-3" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Elexacaftor-tezacaftor-ivacaftor" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Elexacaftor-tezacaftor-ivacaftor</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="539 Role of CFTR high expresser cells in cystic fibrosis intestinal disease"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/s1569-1993(23)01462-5" class="profile-publication-card__link">539 Role of CFTR high expresser cells in cystic fibrosis intestinal disease</a></h5><cite class="profile-publication-card__citation"><strong data-id="69022">Ameen N</strong>, dos Reis D, Dastoor P, Santos A, Cohen M, Donnelley M, Parsons D. 539 Role of CFTR high expresser cells in cystic fibrosis intestinal disease. Journal Of Cystic Fibrosis 2023, 22: s285. <a href="https://doi.org/10.1016/s1569-1993(23)01462-5" target="_blank">DOI: 10.1016/s1569-1993(23)01462-5</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="CFTR High Expresser Cells in cystic fibrosis and intestinal diseases"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/36967909" class="profile-publication-card__link">CFTR High Expresser Cells in cystic fibrosis and intestinal diseases</a></h5><cite class="profile-publication-card__citation">dos Reis D, Dastoor P, Santos A, <span data-id="121074">Sumigray K</span>, <strong data-id="69022">Ameen N</strong>. CFTR High Expresser Cells in cystic fibrosis and intestinal diseases. Heliyon 2023, 9: e14568. <a href="https://pubmed.ncbi.nlm.nih.gov/36967909" target="_blank">PMID: 36967909</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031467" target="_blank">PMCID: PMC10031467</a>, <a href="https://doi.org/10.1016/j.heliyon.2023.e14568" target="_blank">DOI: 10.1016/j.heliyon.2023.e14568</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-4" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-4" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-4" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Cystic%20fibrosis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cystic fibrosis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Intestinal%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intestinal disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Cystic%20fibrosis%20transmembrane%20conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cystic fibrosis transmembrane conductance regulator</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Quality%20of%20life" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Quality of life</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Intestinal%20dysfunction" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intestinal dysfunction</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Gastrointestinal%20diseases" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gastrointestinal diseases</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Intestinal%20physiology" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intestinal physiology</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Fibrosis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Fibrosis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Pathophysiology" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pathophysiology</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Fibrosis%20transmembrane%20conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Fibrosis transmembrane conductance regulator</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Transmembrane%20conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Transmembrane conductance regulator</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CFTR%20lead" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">CFTR lead</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Conductance regulator</span></a></span></div></div></div></div></div></div></article></li></ul></section><section class="profile-publication-card-grouped-list__section" aria-label="2022 Group"><h4 class="profile-publication-card-grouped-list__section-title">2022</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID)"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/35887942" class="profile-publication-card__link">Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID)</a></h5><cite class="profile-publication-card__citation">Ahsan K, dos Reis DC, Barbieri A, <span data-id="121074">Sumigray KD</span>, <span data-id="62678">Nottoli T</span>, Salas PJ, <strong data-id="69022">Ameen NA</strong>. Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID). Journal Of Clinical Medicine 2022, 11: 4179. <a href="https://pubmed.ncbi.nlm.nih.gov/35887942" target="_blank">PMID: 35887942</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319011" target="_blank">PMCID: PMC9319011</a>, <a href="https://doi.org/10.3390/jcm11144179" target="_blank">DOI: 10.3390/jcm11144179</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-5" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-5" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-5" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Microvillus%20inclusion%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Microvillus inclusion disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Severe%20diarrhea" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Severe diarrhea</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Inclusion%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Inclusion disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Fluid%20secretion" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Fluid secretion</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Cystic%20fibrosis%20transmembrane%20conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cystic fibrosis transmembrane conductance regulator</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Double%20knockout%20mice" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Double knockout mice</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Microvillus%20inclusions" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Microvillus inclusions</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Glucocorticoid-inducible%20kinase%201" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Glucocorticoid-inducible kinase 1</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Carbohydrate%20malabsorption" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Carbohydrate malabsorption</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Knockout%20mice" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Knockout mice</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Intestinal%20carbohydrate" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intestinal carbohydrate</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Diarrhea" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Diarrhea</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Diarrheal%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Diarrheal disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Malabsorption" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Malabsorption</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Mice" tabindex="0" class="link link--size--small link--width--float link--align--right 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href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Loss%20of%20MYO5B" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Loss of MYO5B</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Function%20mutations" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Function mutations</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Apical%20cystic%20fibrosis%20transmembrane%20conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Apical cystic fibrosis transmembrane conductance regulator</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Fibrosis%20transmembrane%20conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Fibrosis transmembrane conductance regulator</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Kinase%201" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Kinase 1</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Secretion" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Secretion</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Intestine" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intestine</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Transmembrane%20conductance%20regulator" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Transmembrane conductance regulator</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348250" class="profile-publication-card__link">Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells</a></h5><cite class="profile-publication-card__citation">Hoque K, Hayashi M, Sheikh I, Banerjee A, Verma S, Leblanc N, <span data-id="58810">Zeiss C</span>, <strong data-id="69022">Ameen N</strong>, Chakraborty S. Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells. The FASEB Journal 2022, 36: 10.1096/fasebj.2022.36.s1.0r556. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348250" target="_blank">PMCID: PMC9348250</a>, <a href="https://doi.org/10.1096/fasebj.2022.36.s1.0r556" target="_blank">DOI: 10.1096/fasebj.2022.36.s1.0r556</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy 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currents</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Human%20colorectal%20cancer%20tissues" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human colorectal cancer tissues</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=ANO1%20protein%20expression" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">ANO1 protein expression</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a 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profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1 profile-details-column-list--divided"><li class="profile-details-column-list-item"><article class="profile-details-media-list-item profile-details-media-list-item--right" aria-label="Immunolocalization of NHE3 in Human MVID small intestine"><div class="profile-details-media-list-item__thumbnail-container"><div tabindex="0" role="button" aria-label="View the Immunolocalization of NHE3 in Human MVID small intestine image" class="profile-details-media-thumbnail profile-details-media-thumbnail--clickable profile-details-media-thumbnail--rounded"><span class="" style="display:inline-block"></span></div></div><div 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class="article-post article-post--large"><div class="article-post__date-container"><span class="article-post-date">June 10, 2024</span></div><a href="/news-article/ycsc-2024-summer-interns/" class="article-post-content-link" aria-label="Yale Child Study Center welcomes 2024 summer interns" tabindex="-1"><div class="article-post__thumbnail"><div class="article-post-thumbnail" style="aspect-ratio:16 / 9"><span class="" style="display:inline-block"></span></div></div><div class="article-post__title-wrapper"><h4 class="article-post-title article-post-title--size-mode--large">Yale Child Study Center welcomes 2024 summer interns</h4></div></a><div class="article-post__link-details-wrapper"><div class="article-post-link-details"><a href="/news-article/ycsc-2024-summer-interns/" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue" aria-label="Read more about Yale Child Study Center welcomes 2024 summer interns"><span class="link__label">Read more<span class="visually-hidden-content" role="presentation">about Yale Child Study Center welcomes 2024 summer interns</span></span></a></div></div></article></li><li class="article-list__post article-list__post--large article-list__post--with-bottom-indent"><article aria-label="Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea" class="article-post article-post--large"><div class="article-post__date-container"><span class="article-post-date">July 16, 2020</span></div><a href="https://journals.physiology.org/doi/full/10.1152/ajpgi.00076.2020?_zl=ef4C2&utm_campaign=8.1.2020&utm_medium=email&_zs=Q0INW&utm_source=APSselect" class="article-post-content-link" aria-label="Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea, Source: American Journal of Physiology-Gastrointestinal and Liver Physiology" tabindex="-1"><div class="article-post__title-wrapper"><h4 class="article-post-title article-post-title--size-mode--large">Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea</h4></div><span class="article-source-label article-post__source-label">Source: American Journal of Physiology-Gastrointestinal and Liver Physiology</span></a><div class="article-post__link-details-wrapper"><div class="article-post-link-details"><a href="https://journals.physiology.org/doi/full/10.1152/ajpgi.00076.2020?_zl=ef4C2&utm_campaign=8.1.2020&utm_medium=email&_zs=Q0INW&utm_source=APSselect" tabindex="0" class="link link--size--small link--width--inline link--align--right link--color--black link--font--normal link--decorate-color--light-blue" aria-label="Read more about Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea"><span class="link__label">Read more<span class="visually-hidden-content" role="presentation">about Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea</span></span></a></div></div></article></li></ul></div></div></div></div></section></div></div><div class="profile-details-section-content__sidebar"></div></div></section><section id="get-in-touch-details-section" aria-label="Get In Touch"><header class="profile-details-section-header"><div class="heading__container"><h2 class="profile-details-section-header__heading" tabindex="-1" id="get-in-touch">Get In Touch</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--light"><span 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Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE. Gastroenterology 2024, 166: s-874. <a href=\\\"https://doi.org/10.1016/s0016-5085(24)02489-2\\\" target=\\\"_blank\\\">DOI: 10.1016/s0016-5085(24)02489-2</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE\",\"url\":\"https://doi.org/10.1016/s0016-5085(24)01027-8\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Gastroenterology 2024, 166: s-236. <a href=\\\"https://doi.org/10.1016/s0016-5085(24)01027-8\\\" target=\\\"_blank\\\">DOI: 10.1016/s0016-5085(24)01027-8</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse int\",\"url\":\"https://doi.org/10.1016/s1569-1993(23)01478-9\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. 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Journal Of Cystic Fibrosis 2023, 22: s293-s294. <a href=\\\"https://doi.org/10.1016/s1569-1993(23)01478-9\\\" target=\\\"_blank\\\">DOI: 10.1016/s1569-1993(23)01478-9</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"539 Role of CFTR high expresser cells in cystic fibrosis intestinal disease\",\"url\":\"https://doi.org/10.1016/s1569-1993(23)01462-5\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. 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Journal Of Cystic Fibrosis 2023, 22: s285. <a href=\\\"https://doi.org/10.1016/s1569-1993(23)01462-5\\\" target=\\\"_blank\\\">DOI: 10.1016/s1569-1993(23)01462-5</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"CFTR High Expresser Cells in cystic fibrosis and intestinal diseases\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/36967909\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. 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CFTR High Expresser Cells in cystic fibrosis and intestinal diseases. Heliyon 2023, 9: e14568. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/36967909\\\" target=\\\"_blank\\\">PMID: 36967909</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031467\\\" target=\\\"_blank\\\">PMCID: PMC10031467</a>, <a href=\\\"https://doi.org/10.1016/j.heliyon.2023.e14568\\\" target=\\\"_blank\\\">DOI: 10.1016/j.heliyon.2023.e14568</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusi\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/35887942\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID). Journal Of Clinical Medicine 2022, 11: 4179. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/35887942\\\" target=\\\"_blank\\\">PMID: 35887942</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319011\\\" target=\\\"_blank\\\">PMCID: PMC9319011</a>, <a href=\\\"https://doi.org/10.3390/jcm11144179\\\" target=\\\"_blank\\\">DOI: 10.3390/jcm11144179</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial\",\"url\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348250\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells. 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Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children. </p> <p>My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. We provide conventional standard of care along side nutritional promotion as needed, but focus on foods, exercise, stress reduction and lifestyle as a primary modalities for disease treatment and prevention. </p> <p></p> <p> </p>","workdayTitle":"Professor of Pediatrics (Gastroenterology)","yaleCustomTitles":["Affiliated Faculty, Yale Institute for Global Health"],"nonYaleCustomTitles":[],"labWebsite":null,"cvUrl":null,"ymProfileUrl":null,"boardCertifications":[],"appointments":[{"id":71566,"title":"Professor","type":"Primary","organizationName":"Pediatric Gastroenterology & Hepatology","websiteUrl":"https://medicine.yale.edu/pediatrics/sections/gastroenterology-hepatology/"},{"id":81980,"title":"Professor","type":"Secondary","organizationName":"Cellular & Molecular Physiology","websiteUrl":"https://medicine.yale.edu/physiology/"}],"organizations":[{"id":115019,"name":"Ameen Lab","url":"https://medicine.yale.edu/lab/ameen/"},{"id":108863,"name":"Cellular & Molecular Physiology","url":"https://medicine.yale.edu/physiology/"},{"id":115502,"name":"Discovery to Cure Internship","url":null},{"id":110408,"name":"Molecular Medicine, Pharmacology, and Physiology","url":"https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/"},{"id":118674,"name":"Pediatric Colorectal Disorders Program","url":null},{"id":109198,"name":"Pediatric Gastroenterology & Hepatology","url":"https://medicine.yale.edu/pediatrics/sections/gastroenterology-hepatology/"},{"id":118675,"name":"Pediatric Healthy Gut & Constipation Program","url":null},{"id":108852,"name":"Pediatrics","url":"https://medicine.yale.edu/pediatrics/"},{"id":109532,"name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/"},{"id":118812,"name":"Yale Institute for Global Health","url":"https://medicine.yale.edu/yigh/"},{"id":114820,"name":"Yale Ventures","url":"https://ventures.yale.edu/"}],"educations":[{"degree":"MBBS","institution":"University of West Indies (1985)","dateAwarded":"1985-01-01T00:00:00Z","isTraining":false}],"advancedTrainings":[],"sectionType":"about"},{"config":{"layoutType":"default","statement":null,"quote":null,"stats":{"clinicalTrialInfo":null,"publicationInfo":{"publicationsCount":49,"citationsCount":819,"coAuthorsCount":10,"searchUrl":"/ysm/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen"}}},"displayMode":"default","pageName":"nadia-ameen","fullName":"Nadia Ameen","researchDescription":"<p xmlns=\"http://www.w3.org/1999/xhtml\">Our early studies focussed on identification of trafficking as a major mechanism regulating CFTR in the intestine and its relevance to secretory diarrhea. More recently, we investigate a rare genetic diarrheal disease that affect new borns, Microvillus Inclusion Disease(MVID). We were first to show that MVID results from an apical trafficking defect. Current investigations are elucidating kinase signaling mechanisms regulating ion transport that result in diarrhea in MVID. </p>","meshKeywords":[{"id":881,"keyword":"Antidiarrheals"},{"id":7081,"keyword":"Intestinal Diseases"}],"publicationListing":{"collection":[{"category":"Peer-Reviewed Original Research","pubMedUid":null,"doi":"10.1016/s1569-1993(24)01153-6","altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[{"url":"/ysm/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CHE%20cells","text":"CHE cells"},{"url":"/ysm/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=High-expressing%20cells","text":"High-expressing cells"},{"url":"/ysm/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=CF%20intestine","text":"CF intestine"},{"url":"/ysm/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Expressing%20cells","text":"Expressing cells"},{"url":"/ysm/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Luminal%20pH","text":"Luminal pH"}],"id":"710861^0","title":"313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine","citation":"Jin J, dos Reis D, Muiler C, Zagoren E, Donnelley M, Parsons D, <span data-id=\"121074\">Sumigray K</span>, <strong data-id=\"69022\">Ameen N</strong>. 313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine. Journal Of Cystic Fibrosis 2024, 23: s167. <a href=\"https://doi.org/10.1016/s1569-1993(24)01153-6\" target=\"_blank\">DOI: 10.1016/s1569-1993(24)01153-6</a>.","year":2024,"link":{"url":"https://doi.org/10.1016/s1569-1993(24)01153-6","text":"313 BEST4+ CFTR high expresser cells in normal rat are neuropods that sense and respond to luminal pH and are altered in dF508 CF intestine"}},{"category":"Peer-Reviewed Original Research","pubMedUid":null,"doi":"10.1016/s1569-1993(24)01194-9","altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[{"url":"/ysm/profile/nadia-ameen/academic-publications/?profilePageName=nadia-ameen&concept=Mouse%20intestine","text":"Mouse intestine"}],"id":"710862^0","title":"354 Elucidating the role of signaling and stress on CFTR and its contribution to diarrhea in SGK1 knockout mouse intestine","citation":"Muiler C, Santos A, Dastoor P, Jin J, dos Reis D, Hoque K, <strong data-id=\"69022\">Ameen N</strong>. 354 Elucidating the role of signaling and stress on CFTR and its contribution to diarrhea in SGK1 knockout mouse intestine. 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Journal Of Cystic Fibrosis 2024, 23: s185. <a href=\\\"https://doi.org/10.1016/s1569-1993(24)01194-9\\\" target=\\\"_blank\\\">DOI: 10.1016/s1569-1993(24)01194-9</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocort\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/38925289\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. 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Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta. European Journal Of Pharmacology 2024, 978: 176771. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/38925289\\\" target=\\\"_blank\\\">PMID: 38925289</a>, <a href=\\\"https://doi.org/10.1016/j.ejphar.2024.176771\\\" target=\\\"_blank\\\">DOI: 10.1016/j.ejphar.2024.176771</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE\",\"url\":\"https://doi.org/10.1016/s0016-5085(24)02489-2\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Su1930 STRESS-INDUCED SIGNALING AND CFTR IN SGK1 KNOCK OUT MOUSE INTESTINE. Gastroenterology 2024, 166: s-874. <a href=\\\"https://doi.org/10.1016/s0016-5085(24)02489-2\\\" target=\\\"_blank\\\">DOI: 10.1016/s0016-5085(24)02489-2</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"978 CFTR HIGH EXPRESSER CELLS EXPRESS NEUROPOD GENES AND RESPOND TO ENVIRONMENTAL CUES IN THE INTESTINE\",\"url\":\"https://doi.org/10.1016/s0016-5085(24)01027-8\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Gastroenterology 2024, 166: s-236. <a href=\\\"https://doi.org/10.1016/s0016-5085(24)01027-8\\\" target=\\\"_blank\\\">DOI: 10.1016/s0016-5085(24)01027-8</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"555 Elexacaftor-tezacaftor-ivacaftor and serum glucocorticoid kinase 1 activation on humanized dF508 mouse int\",\"url\":\"https://doi.org/10.1016/s1569-1993(23)01478-9\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. 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Journal Of Cystic Fibrosis 2023, 22: s293-s294. <a href=\\\"https://doi.org/10.1016/s1569-1993(23)01478-9\\\" target=\\\"_blank\\\">DOI: 10.1016/s1569-1993(23)01478-9</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"539 Role of CFTR high expresser cells in cystic fibrosis intestinal disease\",\"url\":\"https://doi.org/10.1016/s1569-1993(23)01462-5\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. My research interest is focused on mechanisms responsible for diarrheal diseases. My lab primarily investigates mechanisms regulating the CFTR chloride channel in the intestine and how these are linked to genetic, and non-genetic diarrheal diseases and Cystic Fibrosis (CF). We elucidated trafficking mechanisms regulating CFTR that are implicated in diarrhea that are the basis for successful drug therapies to treat constipation and increase intestinal fluidity (Linaclotide, Lubiprostone). Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children. My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. We provide conventional standard of care along side nutritional promotion as needed, but focus on foods, exercise, stress reduction and lifestyle as a primary modalities for disease treatment and prevention.\",\"url\":\"https://medicine.yale.edu/profile/nadia-ameen/\",\"email\":\"nadia.ameen@yale.edu\",\"telephone\":\"+12037854649\",\"image\":{\"@type\":\"ImageObject\",\"url\":\"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/5ba2217e-1c37-4041-ba87-0bcf94304a7a\",\"description\":\"YSM7217_0124_N_Ameen\",\"height\":1200,\"width\":630,\"@context\":\"http://schema.org\"},\"address\":[{\"@type\":\"PostalAddress\",\"addressCountry\":\"United States\",\"addressLocality\":\"New Haven\",\"addressRegion\":\"CT\",\"postalCode\":\"06520-8064\",\"streetAddress\":\"PO Box 208064\",\"@context\":\"http://schema.org\"}],\"workLocation\":[{\"@type\":\"Place\",\"name\":\"The Anlyan Center\",\"address\":{\"@type\":\"PostalAddress\",\"addressCountry\":\"United States\",\"addressLocality\":\"New Haven\",\"addressRegion\":\"CT\",\"postalCode\":\"06519\",\"streetAddress\":\"300 Cedar Street, Ste S-160\",\"@context\":\"http://schema.org\"},\"@context\":\"http://schema.org\"}],\"honorificSuffix\":[\"MBBS\"],\"award\":[\"NASPGHAN Award for Study of Disorders Associated with Carbohydrate Malabsorption 2020\"],\"jobTitle\":[\"Professor of Pediatrics (Gastroenterology)\"],\"affiliation\":[{\"@type\":\"Organization\",\"name\":\"Ameen Lab\",\"url\":\"https://medicine.yale.edu/lab/ameen/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Cellular & Molecular Physiology\",\"url\":\"https://medicine.yale.edu/physiology/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Discovery to Cure Internship\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Molecular Medicine, Pharmacology, and Physiology\",\"url\":\"https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Pediatric Colorectal Disorders Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Pediatric Gastroenterology & Hepatology\",\"url\":\"https://medicine.yale.edu/pediatrics/sections/gastroenterology-hepatology/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Pediatric Healthy Gut & Constipation Program\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Pediatrics\",\"url\":\"https://medicine.yale.edu/pediatrics/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Combined Program in the Biological and Biomedical Sciences (BBS)\",\"url\":\"https://medicine.yale.edu/bbs/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Institute for Global Health\",\"url\":\"https://medicine.yale.edu/yigh/\",\"@context\":\"http://schema.org\"},{\"@type\":\"Organization\",\"name\":\"Yale Ventures\",\"url\":\"https://ventures.yale.edu/\",\"@context\":\"http://schema.org\"}],\"alumniOf\":[{\"@type\":\"Organization\",\"name\":\"University of West Indies (1985)\",\"@context\":\"http://schema.org\"}],\"sameAs\":[],\"@context\":\"http://schema.org\"}],\"description\":\"<strong data-id=\\\"69022\\\">Ameen N</strong>, dos Reis D, Dastoor P, Santos A, Cohen M, Donnelley M, Parsons D. 539 Role of CFTR high expresser cells in cystic fibrosis intestinal disease. Journal Of Cystic Fibrosis 2023, 22: s285. <a href=\\\"https://doi.org/10.1016/s1569-1993(23)01462-5\\\" target=\\\"_blank\\\">DOI: 10.1016/s1569-1993(23)01462-5</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"CFTR High Expresser Cells in cystic fibrosis and intestinal diseases\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/36967909\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. My research interest is focused on mechanisms responsible for diarrheal diseases. My lab primarily investigates mechanisms regulating the CFTR chloride channel in the intestine and how these are linked to genetic, and non-genetic diarrheal diseases and Cystic Fibrosis (CF). We elucidated trafficking mechanisms regulating CFTR that are implicated in diarrhea that are the basis for successful drug therapies to treat constipation and increase intestinal fluidity (Linaclotide, Lubiprostone). Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children. My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. 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CFTR High Expresser Cells in cystic fibrosis and intestinal diseases. Heliyon 2023, 9: e14568. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/36967909\\\" target=\\\"_blank\\\">PMID: 36967909</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031467\\\" target=\\\"_blank\\\">PMCID: PMC10031467</a>, <a href=\\\"https://doi.org/10.1016/j.heliyon.2023.e14568\\\" target=\\\"_blank\\\">DOI: 10.1016/j.heliyon.2023.e14568</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusi\",\"url\":\"https://pubmed.ncbi.nlm.nih.gov/35887942\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID). Journal Of Clinical Medicine 2022, 11: 4179. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/35887942\\\" target=\\\"_blank\\\">PMID: 35887942</a>, <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319011\\\" target=\\\"_blank\\\">PMCID: PMC9319011</a>, <a href=\\\"https://doi.org/10.3390/jcm11144179\\\" target=\\\"_blank\\\">DOI: 10.3390/jcm11144179</a>.\",\"@context\":\"http://schema.org\"}"},{"schemaName":"MedicalScholarlyArticle","jsonData":"{\"@type\":\"MedicalScholarlyArticle\",\"publicationType\":\"Journal Article\",\"inLanguage\":\"en-US\",\"headline\":\"Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial\",\"url\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348250\",\"author\":[{\"@type\":\"Person\",\"name\":\"Nadia Ameen\",\"description\":\"I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. 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Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells. The FASEB Journal 2022, 36: 10.1096/fasebj.2022.36.s1.0r556. <a href=\\\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348250\\\" target=\\\"_blank\\\">PMCID: PMC9348250</a>, <a href=\\\"https://doi.org/10.1096/fasebj.2022.36.s1.0r556\\\" target=\\\"_blank\\\">DOI: 10.1096/fasebj.2022.36.s1.0r556</a>.\",\"@context\":\"http://schema.org\"}"}]}}],"sidebarComponents":[],"contextNavigation":null}</script> <script>window['applicationSettings'] = {"shouldShowSuppressedImageWarnings":false,"shouldShowBugReportButton":false,"shouldShowDownloadAsWordButton":false,"captchaKey":"a46dfca5-98da-4ec7-83e2-16980be648d0","facebookShareUrl":"https://www.facebook.com/dialog/share?app_id=604142276782606&display=popup&href=","isSearchFeedbackEnabled":true,"isSearchAnalyticsEnabled":true,"siteimproveScriptUrl":"https://siteimproveanalytics.com/js/siteanalyze_373.js","radarKey":"prj_live_pk_e9bc38cc9ac871b02332c0d599d7a893c03ad94d","mediaStatistics":{"baseUrl":"https://media-statistics-prod.ysmdevs.com","apiKey":"249c64e3-d0cc-45ed-97a0-5d3106411485","isEnabled":true}};</script> <noscript id="modern__LOADABLE_REQUIRED_CHUNKS__">[4589,7640,6443,4480,6736,6293,5666,8707,6325,1739,8404,2944,3053]</noscript><noscript id="modern__LOADABLE_REQUIRED_CHUNKS___ext">{"namedChunks":["modules-page-components-ComponentWrapper","modules-profile-components-profile-details-ProfileDetails","modules-footer-components-Footer"]}</noscript> <script async data-chunk="main" src="https://cdn1.medicine.yale.edu/build/main.es2015.e71226adbc7ac9e6afaf.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/4589.es2015.4c47bf8350b6c4f009a0.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/7640.es2015.305f7f9c55b908f8d7a2.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6443.es2015.4890cbc400a8796edee4.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/4480.es2015.473ffd08eabb889a822c.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6736.es2015.36fcc1e83004e7c6188d.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6293.es2015.a955a43c28f0a24dd4fa.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/5666.es2015.f47cd983c67020627178.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/8707.es2015.0f85929e46010fd82776.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6325.es2015.3731caff209d628cedac.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/1739.es2015.9ce9a21bd840865df3b8.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/8404.es2015.44ae95a8c2402548bad5.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/2944.es2015.ac9b45323eabedf3adb7.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-footer-components-Footer" src="https://cdn1.medicine.yale.edu/build/3053.es2015.404cba0e717f410cb74c.js" type="module" crossorigin="anonymous"></script> <link rel="stylesheet" href="https://use.typekit.net/eqf4dwf.css" as="style" crossorigin>  <script async type="text/plain" data-cookiecategory="analytics" src="https://siteimproveanalytics.com/js/siteanalyze_373.js"></script> </body> </html>

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Nadia Ameen, MBBS < Yale School of Medicine