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<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-VNS5L9E4H7"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-VNS5L9E4H7", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <link rel="canonical" href="https://www.bccrc.ca/dept/mo/resources" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/mo/sites/molecularoncology/files/BCClogo_Research_MolecularOncology_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <link rel="icon" href="/dept/mo/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Resources | Molecular Oncology</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_Bxn9zpdS07My99x7G76QyiQFY-SQtLPW6RDCCblqJIQ.css?delta=0&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_b1Imd5Zfo6d9UtggtC_ak93-Ac2c67PnthKR5yWdzt8.css?delta=2&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> </head> <body class="colour--emerald not-front path--node page--page"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--page page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/dept/mo/">Molecular Oncology</a> </li> <li> Resources </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Resources</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <section class="layout layout__expanding layout__parent__node has-expanding-text paragraph paragraph--type--expanding paragraph--view-mode--default" id="paragraph--126"> <h2 class="section__title" data-expand="field--field_text">Computational Biology Software</h2> <div class="field field--field_expanding_summary">The computational biology team develop analytical software with broad distribution through open source repositories.</div> <button class="icon" data-expand></button> <div class="field field--field_text"> <p>Our research group develops computational methods for the analysis of high throughput cancer genomics data.  We use machine learning techniques to develop statistical models to infer genomic abnormalities from next generation sequencing data and high-density genotyping arrays.  Dr. Andrew Roth and Dr. Sohrab Shah work with Dr. David Huntsman and Dr. Sam Aparicio who lead ovarian cancer and breast cancer research respectively at BC Cancer, part of the Provincial Health Services Authority. We focus on the analysis of clinical samples with the goal of detecting genetic abnormalities in tumour genome that might be developed into diagnostics, prognostics or novel therapeutic targets.  Most of our software is released under an open source license and is free to <a href="https://shahlab.ca/projects/" target="_blank">download here</a>.</p></div> </section> <section class="layout layout__expanding layout__parent__node has-expanding-text paragraph paragraph--type--expanding paragraph--view-mode--default" id="paragraph--141"> <h2 class="section__title" data-expand="field--field_text">Precision Medicine for Breast Cancer Research (B-PRECISE) Biorepository</h2> <div class="field field--field_expanding_summary">The  Department of Molecular Oncology hosts the Precision Medicine for Breast Cancer Research (B-PRECISE) biorepository. </div> <button class="icon" data-expand></button> <div class="field field--field_text"> <p>A biobank collects, stores and gives out to other researchers human samples (for example, tissue, saliva, blood, fluids, stem cells, blood etc) health records treatment and diagnostic data connected to these samples. Our primary biobanking protocol,B-PRECISE, Tumor Tissue Repository (B-PRECISE, TTR) primary goal is to collect biological specimens  including residual tumor tissues through best practices. Through this, our researchers will develop new tools that could be used for precision medicine to help patients in the future. As of 2019, our biorepository at the BC Cancer Research Centre in Vancouver holds approximately 8000 breast cancer specimens. </p><p>Our Research platform has developed Mission, Vision and Objective statements and defined 4 areas of investigation.</p><p><strong>MISSION</strong><br>B-PRECISE is committed to reducing the burden of breast cancer by identifying the causes and treatment interventions for individuals.</p><p><strong>VISION</strong><br>The B-PRECISE biorepository will support  research studies by facilitating access to a unique population- based resource that will enable translational research and ultimately result in improved treatment and intervention for individuals with breast cancer. </p><p><strong>OBJECTIVES</strong><br>To build a research resource which includes  tissue, blood and data (including sequencing data, imaging, treatment, monitoring, and outcomes data ) from a cohort of newly diagnosed breast cancer patients from across  British Columbia (BC) <br>Our biorepository is comprised of specimens from participants all over BC as well as collaborative  cases/data that came from the UK. The Canada-UK project named METABRIC aimed to classify breast tumors into further subcategories, based on molecular signatures to help determine the optimal course of treatment. You can read more on the METABRIC study here: <a href="http://molonc.bccrc.ca/aparicio-lab/research/metabric/" target="_blank">http://molonc.bccrc.ca/aparicio-lab/research/metabric/</a></p><p><strong>AREAS OF INVESTIGATION</strong><br>Currently, our B-PRECISE research program has four primary areas of investigation:<br>1. Studying single cells to fully understand the biology of breast cancer and identify new  subtypes, including “omics” analysis.<br>2. Identifying patterns associated with disease response with an aim to develop new diagnostic tools<br>3. Assessing the effectiveness of standard of care treatments<br>4. Supporting collaborative research with investigators in breast cancer and cancer mechanisms<br>in general outside of the B-precise program. </p><p>If you have questions about our B-PRECISE  Biorepository please contact:</p><p><br>Principal Investigator and Director <br>Dr. Samuel Aparicio <br><a href="mailto:saparicio@bccrc.ca">saparicio@bccrc.ca</a><br>Or <br>Project Manager - Clinical Studies<br>Esther Kong<br><a href="mailto:ekong@bccrc.ca">ekong@bccrc.ca</a></p></div> </section> </section> </div> </section> </div> <a class="top" href="#main-content">Back to top</a> </main> <section class="region region__cta"> <div class="region__cta--inner region--inner"> <section id="block-sitecalltoaction" class="block block--block-contenta8a59224-4648-42d5-b71c-294b3c630d8a block-sitecalltoaction"> <div class="field field--body"><p>BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. Together with our donors, we are changing cancer outcomes for British Columbians by funding innovative research and personalized treatment and care.</p> <p><a class="button" href="https://bccancerfoundation.com/donations/general-donation-form/?s_src=BCCRCFooter" target="_blank">Donate Today</a></p></div> </section> </div> </section> <footer class="page" role="contentinfo"> <section class="region region__footer"> <div class="region__footer--inner region--inner"> <section id="block-bccrc-branding" class="block block--system-branding-block block-bccrc-branding"> <a href="/dept/mo/" title="Home" rel="home"> <img src="/dept/mo/sites/molecularoncology/files/BCClogo_Research_MolecularOncology_RGB.png" alt="Home" /> </a> </section> <section id="block-contactus" class="block block--block-content2314a90f-9af6-4a1e-8cf5-6a294688e075 block--contact-us block-contactus"> <h2 class="section__title">Contact Us</h2> <div class="field field--body"><p>BC Cancer Research Institute<br> 675 West 10th Avenue<br> Vancouver, BC V5Z 1L3</p> <p>604 675 8000</p> <p>Toll Free: 1 888 675 8001</p></div> </section> <section id="block-followus" class="block block--block-content06fb6d8a-948b-4134-bf4f-c16a4f797215 block--follow-us block-followus"> <h2 class="section__title">Follow Us</h2> <div class="field field--body"><p><a class="fa fa-linkedin" href="https://www.linkedin.com/company/bc-cancer/"> </a><a class="fa fa-twitter" href="https://twitter.com/BCCancer"> </a><a class="fa fa-instagram" href="https://www.instagram.com/bccancer/"> </a></p></div> </section> <section id="block-phsa" class="block block--block-contente498e60d-8221-412d-8ddc-717f5bb18010 block-phsa"> <div class="field field--body"><p><a href="http://www.phsa.ca" target="_blank"><img alt="PHSA" src="https://www.bccrc.ca/dept/mo/sites/molecularoncology/files/PHSA-logo.svg"></a></p></div> </section> </div> </section> </footer> <section class="region region__copyright"> <div class="region__copyright--inner region--inner"> <nav role="navigation" aria-labelledby="block-bccrc-footer-menu" id="block-bccrc-footer"> <h2 class="visually-hidden" id="block-bccrc-footer-menu">Footer menu</h2> <ul class="menu"> <li class="menu-item"> <a href="http://www.phsa.ca/privacy">Privacy Policy</a> </li> <li>Copyright © BC Cancer. 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